| Entries |
| Document | Title | Date |
|---|
| 20080241350 | Method for fabricating a medical component from a material having a high carbide phase - A method of fabricating a medical implant component. The method may comprise producing a substrate from a first material in which the substrate has a bearing portion, and spraying particles of a second material by use of a thermal type spraying process onto at least the bearing portion of the substrate. The second material may be formed from a biocompatible material and a carbide source, in which the carbide source is 6.17% or more of the second material by weight. The biocompatible material may be cobalt chrome and the carbide source may be graphite. The thermal type spraying process may be a plasma spraying process or a high velocity oxygen fuel spraying process. | 10-02-2008 |
| 20090053391 | Method Of Coating A Drug-Releasing Layer Onto A Substrate - This invention relates to processes for coating a substrate with a drug-containing layer in which the microstructure of the resulting dry drug reservoir layer is not a function of solvent removal. | 02-26-2009 |
| 20090061071 | Porous medical articles for therapeutic agent delivery - According to an aspect of the present invention a method is provided which a porous medical article is contacted with a solution that contains a therapeutic agent and a solvent in order to load the pores of the medical article, after which the solvent is sublimated. | 03-05-2009 |
| 20090074944 | ENTERIC COATINGS FOR ORALLY INGESTIBLE COMPOSITIONS - A suspendible enteric coating composition for encasing orally ingestible articles wherein the enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three step method for providing a stable outer enteric coating on an ingestable item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition. | 03-19-2009 |
| 20090092739 | METHOD OF DIP-COATING DOSAGE FORMS - Water soluble, gelatin-free dip coatings for tablets and capsules comprising sucrose, glycerin and pre-gelatinized starch and/or tapioca dextrin or comprising hydroxypropyl starch, thickener, and plasticizer. | 04-09-2009 |
| 20090136650 | ENTERIC COATINGS FOR ORALLY INGESTIBLE COMPOSITIONS - A dry suspendible enteric coating composition for suspension in water and then encasing orally ingestible articles. The dry suspendible enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three-step method for providing a stable outer enteric coating on an ingestible item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition. | 05-28-2009 |
| 20090220676 | Multi-stage coating device for moulded bodies - The invention relates to a quasi-continuously operating coating device for the coating of moulded bodies, in particular for pharmaceutical products, such as tablets, drops, pressed moldings and granulates. The coating device comprises a rotating coating drum, divided into several drum longitudinal sections by a transport element, whereby the introduction of the process medium for all segments occurs individually and depending on the appropriate stage of the coating process. The moulded bodies are conveyed through the drum in an axial direction by means of said transport element. In an ideal embodiment the transport element is in the form of a cylindrical screw. | 09-03-2009 |
| 20090311414 | PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT - A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts ( | 12-17-2009 |
| 20090324802 | METHOD FOR PRODUCING SPHERICAL BASE GRANULES COMPRISING HARDLY WATER-SOLUBLE DRUG - Spherical base granules comprising a hardly water-soluble drug and suited for film coating thereon are produced by layering spherical core particles with a drug-containing layering liquid comprising both micronized microcrystalline cellulose and an emulsifier therein and therefore having improved suspension stability. | 12-31-2009 |
| 20100047435 | Hydrogel Attached to Backing and Method for Making Same - The present invention relates to a method of making a preformed hydrogel attach to a polymer backing comprising exposing a surface of the backing to an activated gas and depositing the preformed hydrogel on the exposed surface of the backing, and hydrogel products so formed. This hydrogel product can be used as an active ingredient delivery device, a wound cover and a diagnostic tool. It advantageously replaces hydrogel products using chemicals as adhesive agents. | 02-25-2010 |
| 20100098832 | PREPARATION OF CONTROLLED RELEASE SKELETAL MUSCLE RELAXANT DOSAGE FORMS - The present invention is directed to a method of preparing an extended release pharmaceutical composition comprising cyclobenzaprine, comprising coating inert particles with a cyclobenzaprine-containing a drug layering composition to form IR beads, then coating the IR beads with an extended-release coating to form ER beads. | 04-22-2010 |
| 20100098833 | METHOD OF CONTROLLING A DRUG RELEASE RATE - A method of controlling the drug release rate of a drug coated endovascular stent by depositing a drug material layer on the stent and then modifying the drug material using gas cluster ion beam irradiation to create a carbon matrix with interstices containing the original drug. The rate at which the drug elutes through the interstices can be controlled by processing parameters. Multiple layers may be employed to create time varying release rates. | 04-22-2010 |
| 20100112188 | NOVEL STABLE BEADLETS OF LIPOPHILIC NUTRIENTS - The invention disclosed in this application relates to novel stable beadlets of lipophilic nutrients comprising an inert core having a coating of stabilizing antioxidants, lipophilic nutrients, or mixtures thereof. The beadlets may be coated with one or more coatings to protect the lipophilic ingredients from the atmosphere, specifically the coatings can be used to protect against moisture and/or oxygen. The invention also relates to a process for the preparation of the stable beadlets. The beadlets can be used in medicines and dietary supplements intended to facilitate the reduced risk of macular degeneration, cataract, and several forms of cancer. | 05-06-2010 |
| 20100189878 | PROCESSES FOR COATING A CARRIER WITH MICROPARTICLES - Processes for coating a carrier with microparticles of a drug are described. For example, a coated carrier can be obtained in a one-stage process that entails evaporating a solvent from microdroplets of a solution containing an API to obtain dry microparticles, which are then coated on the carrier. | 07-29-2010 |
| 20100203227 | TEMPERATURE TELEMETRY IN PROCESSING OF MATERIAL - In the process of coating pharmaceutical tablets in a moving bed, the temperature of the tablets is measured by incorporating a temperature transducer in the form of tablet into the bed of tablets, and transmitting temperature data to an external receiver by wireless telemetry. | 08-12-2010 |
| 20100203228 | METHOD FOR PRODUCTION OF COATED PREPARATIONS - The present invention relates to a method for production of a coated preparation, characterized by coating a core material with a coating solution, the core material comprising an active ingredient, the coating solution comprising a) a resin composition obtained by copolymerization of polyvinyl alcohol having an average polymerization degree of 1300 or less, and at least one polymerizable vinyl monomer in a weight ratio of 6:4 to 9:1, b) water, and c) an organic solvent. The method for production make it feasible to efficiently coat a preparation such as a tablet, a granule, and a fine granule, etc. (a pharmaceutical drug, an animal drug, an agricultural chemicals, a fertilizer, or a food product) with the coating solution comprising a) the composition comprising the polyvinyl alcohol copolymer as the main component, b) water, and c) the organic solvent. | 08-12-2010 |
| 20100247737 | METHOD FOR PRODUCING GRANULATED PREPARATION - It has been desired to provide a method for producing a granulated preparation capable of maintaining a stability of a chemically unstable substance in a neutral or acidic region for a long period of time with a simple and safe method in a preparation procedure, and a tablet produced by using the method. | 09-30-2010 |
| 20100304006 | METHOD OF MANUFACTURING SILICA-COATED METAL NANOPARTICLES - A method of producing silica-coated metal nanoparticles with at least one tetraalkoxysilane, from nanoparticles, referred to as metal nanoparticles, includes a quantity of at least one metal of zero oxidation state, a quantity of a catalytic hydrolysis composition, a quantity of liquid solvent medium and a quantity of water, so as to obtain a hydrolysis/condensation enabling the metal nanoparticles to be coated with silica, wherein the liquid solvent medium consists of at least one solvent chosen from the group formed by non-alcoholic organic solvents. | 12-02-2010 |
| 20100323090 | METHOD FOR PRODUCTION OF ORALLY RAPIDLY DISINTEGRATING TABLET COMPRISING IMIDAFENACIN AS ACTIVE INGREDIENT - The present invention herein provides an imidafenacin-containing orally rapidly disintegrating tablet which is excellent in the photostability. | 12-23-2010 |
| 20110008526 | MULTI-LAYERED COATINGS AND METHODS FOR CONTROLLING ELUTION OF ACTIVE AGENTS - Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a coating solution onto the substrate to form a base layer. The method can also include selecting a desired concentration of the solvent based on a desired elution rate. The method can further include removing solvent from the base layer to reach a desired concentration of the solvent and depositing a layer of parylene on the base layer. In an embodiment, the invention can include a medical device including a substrate, a base layer, and a porous layer. The base layer can include a polymeric matrix and an active agent dispersed within the polymeric matrix. The porous layer can include parylene. Other embodiments are also included herein. | 01-13-2011 |
| 20110014352 | METHOD AND APPARATUS FOR PRODUCING A CENTRED COMPRESSION COATED TABLET - The present invention provides a method and apparatus for positioning the core of the compression coated tablet in manufacturing techniques for the production of such tablets. | 01-20-2011 |
| 20110027454 | Dried Formulations of Nanoparticle-Coated Capsules - A method of producing a dried formulation for an active substance such as a drug compound is described. The method involves dispersing a discontinuous phase (e.g. an oil-based or lipidic medium) comprising the active substance into a continuous phase (e.g. water) so as to form a two-phase liquid system comprising droplets of said discontinuous phase, allowing nanoparticles to congregate at the phase interface at the surface of the droplets such that at least one layer of nanoparticles coat the droplets and thereby provide sufficient structural integrity to the droplets to enable the subsequent removal of the continuous phase, and thereafter removing the continuous phase from the nanoparticle-coated droplets to produce a dried formulation. | 02-03-2011 |
| 20110059226 | METHOD FOR LOADING A MOLECULE INTO A POROUS SUBSTRATE - A method for loading a molecule into a porous substrate. The molecule has the formula | 03-10-2011 |
| 20110064867 | PROCESS FOR MANUFACTURING FLOWABLE POWDER DRUG COMPOSITIONS - Powder drug compositions exhibiting improved flow properties are manufactured by spraying a suspension of surface-modified nanoparticles having an average particle size diameter of less than 100 nm in a dryable liquid carrier onto particles of a powder ingredient of a drug composition. The liquid carrier is rapidly dried so as to leave the nanoparticles on the powder. Other ingredients of the powder drug composition can also be added. | 03-17-2011 |
| 20110104362 | METHOD OF MAKING A DRY POWDER PHARMACEUTICAL COMPOSITION - A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed. | 05-05-2011 |
| 20110143014 | COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 06-16-2011 |
| 20110151103 | System and a Method for Pharmaceutical Dosage Preparation Using Jettable Microemulsions - A jettable solution includes an oil, the oil being one of a naturally occurring oil, an edible oil, or a removable oil, an edible surfactant, an edible aqueous solution, and a pharmaceutical solubilized into the naturally occurring oil, in which the naturally occurring oil, the pharmaceutical, the surfactant, and the aqueous solution form a microemulsion. | 06-23-2011 |
| 20110177231 | Nano-, Micro-, Macro- Encapsulation And Release Of Materials - This invention relates to nano-, micro-, and macro-encapsulation methods and constructs, including single and multi-compartment particles and capsules, and methods of release. | 07-21-2011 |
| 20110206827 | FILM-COATED TABLET OR GRANULES CONTAINING AS ACTIVE INGREDIENT A PYRIDYLPYRIMIDINE COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THIS COMPOUND - Film-coated tablet, consisting of a tablet core with a film coating, or granules containing as active ingredient a pyridylpyrimidine compound or a pharmaceutically acceptable salt of this compound, preferably imatinib or a pharmaceutically acceptable salt of imatinib, preferably imatinib monomethanesulfonate, wherein (i) the tablet cores and the granules have been produced by pressing of the starting materials and, prior to pressing of the starting materials, at least one of them has been dry-granulated, preferably compacted; (ii) the tablet cores and granule cores contain the active ingredient in a proportion of 25% by weight to 80% by weight, based on the total weight of the tablet cores or granule cores, together with (iii) at least one filler-binder, and optionally contain other additives; and (iv) the mean particle size distribution of at least 80% of the active ingredient is in the range from 0.01 mm to 1.0 mm. | 08-25-2011 |
| 20110256304 | Ceramic Encapsulation By Use of One or More Specialized Silanes To Template Oil In An Oil In Water Emulsion - This invention relates to a method for emulsion templating hollow silica-based particles. The particles are suitable for containing one or more active ingredients or for containing other smaller particles which may include one or more active ingredients. The emulsion templated particles can be formed from two or more silanes. The emulsion templated particles can also be formed from a silane and a compound that attaches a polymer on the shell of the hollow silica-based particles. | 10-20-2011 |
| 20110274819 | Oral preparation with controlled release - A pharmaceutical pellet is disclosed, comprising a spherical core containing active ingredient with a smooth surface and a coating on the core which controls the release of the active ingredient in a pH-independent manner. With such a pellet the release of the active ingredient can follow a profile with a lag phase of 60 minutes to 840 minutes, a proportion of 5 wt. % or less of the active ingredient being released during the lag phase. The active ingredient can furthermore be released from the pellet with a profile such that after the lag phase the release of the active ingredient amounts to between 3 and 25 wt. % per hour. | 11-10-2011 |
| 20120076921 | METHOD AND SYSTEM FOR FORMING A PHARMACEUTICAL PRODUCT DIRECTLY ONTO A PACKAGING SURFACE - The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate. | 03-29-2012 |
| 20120094007 | METHOD FOR THE IMMOBILIZATION OF CATIONIC ACTIVE INGREDIENTS ON SURFACES - A method and composition for immobilizing an antimicrobial active ingredient on a surface of a substrate, in which the surface of the substrate is treated with a composition comprising
| 04-19-2012 |
| 20120094008 | Nano- and Micro- Encapsulation of Biomaterials Into Particles and Capsules by Varying Precipitation Conditions - This invention describes novel methods for fabricating nano/micro particles and capsules through template decomposition which incorporates the to-be-encapsulated molecules which are precipitated in pores of particles or in solution, i.e. below their isoelectric point, drying or by solvent adjustment methods. The encapsulation process can be followed by a deposition or adsorption of a protective shell that regulates release of the encapsulated material. The encapsulation, inclusion, manipulation, and release of various materials and bio-materials is to be conducted by delivery vehicles which are particles and capsules with sizes in the range of nanometers and micrometers. They can possess multicompartment and anisotropic geometries and can carry one or several types of various molecules. This invention can potentially be used for controlled delivery, manipulation, and release in a variety of applications requiring delivery vehicles such as cell cultures, in-vivo, subcutaneous incorporation, injection, spray-inhalation and planar surfaces, films, and stents. | 04-19-2012 |
| 20120100278 | FILMS FOR USE AS DOSAGE FORMS - Non-gelatin film materials, e.g. films of modified cellulose materials find use as dosage forms. Substances are incorporated into the film matrix and films thus prepared may be administered orally, or otherwise internally, or epidermally. The administable form may comprise a matrix which contains at least one water soluble polymer in the form of a film, in addition to at least one active ingredient, to produce a therapeutic, organoleptic or cosmetic effect. | 04-26-2012 |
| 20120114831 | HIGH EFFICIENCY ENCAPSULATION OF CHARGED THERAPEUTIC AGENTS IN LIPID VESICLES - Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%. | 05-10-2012 |
| 20120189760 | MULTILAYERED POLYELECTROLYTE-BASED CAPSULES FOR CELL ENCAPSULATION AND DELIVERY OF THERAPEUTIC COMPOSITIONS - The present invention provides novel, biocompatible matrices for cell encapsulation and transplantation. If further provides methods for delivering agents to encapsulate cells and to the local environment of a host system. The invention also provides methods for targeting and manipulating particular cells and/or proteins of the host system. In a composition aspect of the invention, a composition including a collection of capsules is provided. The capsules comprise an inner core, and the inner core is covered by an outer shell composed of a positive polyelectrolyte and a negative polyelectrolyte. The inner core of the capsules contains at least one cell. | 07-26-2012 |
| 20120207913 | METHODS AND SYSTEMS FOR DOSING AND COATING INHALATION POWDERS ONTO CARRIER PARTICLES - A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent. | 08-16-2012 |
| 20120219694 | Production Of Pulverulent Coating Compositions For Stable Protective Coatings For Pharmaceutical Dosage Forms - Described are processes for producing pulverulent coating compositions comprising providing an aqueous polymer dispersion comprising
| 08-30-2012 |
| 20120219695 | Production Of Pulverulent Coating Compositions For Stable Protective Coatings For Pharmaceutical Dosage Forms - Described is a process for producing pulverulent, antioxidant-comprising coating compositions, comprising providing an aqueous polymer dispersions comprising one or more antioxidants and a polymer obtained by radical polymerization of
| 08-30-2012 |
| 20130059062 | Device For The Manufacture Of A Dosage Form With A Hole And Method Of Manufacture - This invention is related to a device for the manufacture of a dosage form with a hole and method of manufacture. The dosage form may be a modified release dosage form comprising a core coated with a polymeric coat comprising one or more rate controlling polymers, said dosage form having a hole extending through the dosage form resulting in an inner radial surface and an outer radial surface, said core comprising at least one therapeutically active ingredient, characterized in that the inner radial surface is partially coated with said polymeric coat. | 03-07-2013 |
| 20130064965 | IMPLANTS FOR ADMINISTERING SUBSTANCES AND METHODS OF PRODUCING IMPLANTS - A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-erodible doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached. | 03-14-2013 |
| 20130108774 | METHOD FOR PRODUCING A DRUG DELIVERY SYSTEM ON THE BASIS OF POLYELECTROLYTE COMPLEXES | 05-02-2013 |
| 20130136848 | POLYMERISATION PROCESS AND POLYMER PRODUCT - A method of polymerising monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabiliser for said particulate material, and said continuous liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said RAFT agent to thereby form polymer at the surface of said particulate material. | 05-30-2013 |
| 20130156934 | MICROCAPSULES BY COACERVATION CONTAINING A PHARMACEUTICAL INCORPORATED IN THE COATING POLYMER - Microcapsules containing an active ingredient, constituted by a core coated with a polymer membrane, characterized in that the active ingredient is incorporated in the polymer coating layer, and in that said layer is applied using microencapsulation techniques (coacervation by means of phase separation). The microcapsules; thus produced have excellent properties of taste masking and prolonged release of the active ingredients. | 06-20-2013 |
| 20130171332 | SOLID DISPERSION PREPARATION - A granule or a tablet of a solid dispersion that allows a drug in a preparation to be rapidly dissolved without impairing dissolving of the solid dispersion, and a method for producing same is composed of 1 to 10% by weight of a poorly soluble drug, a water-soluble polymer, an excipient and 15 to 50% by weight if a disintegrator; a tablet of a solid dispersion composed of a poorly soluble drug, 1 to 5% by weight of a water-soluble polymer, an excipient and 15 to 50% by weight of a disintegrator; and a method for producing a granule or tablet of a solid dispersion comprising spraying a water-soluble polymer solution, in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder of an excipient and a disintegrator, and granulating and drying a resultant. | 07-04-2013 |
| 20130171333 | SOLID DISPERSION PREPARATION - A granule or a tablet of a solid dispersion that allows a drug in a preparation to be rapidly dissolved without impairing dissolving of the solid dispersion, and a method for producing same is composed of 1 to 10% by weight of a poorly soluble drug, a water-soluble polymer, an excipient and 15 to 50% by weight if a disintegrator; a tablet of a solid dispersion composed of a poorly soluble drug, 1 to 5% by weight of a water-soluble polymer, an excipient and 15 to 50% by weight of a disintegrator; and a method for producing a granule or tablet of a solid dispersion comprising spraying a water-soluble polymer solution, in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder of an excipient and a disintegrator, and granulating and drying a resultant. | 07-04-2013 |
| 20130171334 | METHOD FOR THE SURFACE TREATMENT OF A FLUID PRODUCT DISPENSING DEVICE - A method of surface treating a fluid dispenser device, the method including a step of modifying at least one surface to be treated of at least a portion of the device by ionic implantation using multi-charged and multi-energy ion beams. The modified surface to be treated has anti-friction properties, the multi-charged ions are selected from helium (He), nitrogen (N), oxygen (O), neon (Ne), argon (Ar), krypton (Kr), and xenon (Xe), and ionic implantation is carried out to a depth of 0 μm to 3 μm. | 07-04-2013 |
| 20130183433 | STABILIZED PICOPLATIN ORAL DOSAGE FORM - The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox- active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the pieoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant. | 07-18-2013 |
| 20130202778 | PROCESS FOR DRY POWDER FORMULATIONS - The present invention relates to a process developed for production of a dry powder medicament used in respiratory tract diseases such as asthma and COPD. | 08-08-2013 |
| 20130302508 | Water Dispersible Glyceryl Monooleate Magnetic Nanoparticle Formulation - The present invention is an aqueous dispersible magnetic nanoparticle formulation with a high drug loading capacity used for sustained drug delivery. The formulated magnetic nanoparticles are composed of an iron oxide core coated with a long chain polymer, which provides aqueous dispersibility without the use of surfactant. A method is developed for the functionalization of magnetic nanoparticles for use in biomedical field. | 11-14-2013 |
| 20130337148 | THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM - The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity. | 12-19-2013 |
| 20140004251 | HOLLOW BIODEGRADABLE NANOSPHERES AND NANOSHELLS FOR DELIVERY OF THERAPEUTIC AND/OR IMAGING MOLECULES | 01-02-2014 |
| 20140087058 | METHOD FOR PRODUCING ENCAPSULATED NANOPARTICLES - A method is provided that produces nanocomposite materials containing well-dispersed, nanoparticles encapsulated in a polymer matrix. A feedstock comprising a colloidal dispersion of nanoparticles in a solvent and a polymer dissolved in the same solvent is passed through an ultrasonic nozzle using a flow control device, producing an aerosol of drops having diameters less than about 100 micrometers. The aerosol of drops is then mixed with a fluid that is miscible with the solvent, is a nonsolvent for the polymer, and destabilizes the colloidal dispersion. As a result, well-dispersed polymer-encapsulated nanoparticles precipitate. The method operates at atmospheric temperature and pressure and allows for independent control of the precipitation of the particle and of the polymer. | 03-27-2014 |
| 20140087059 | PHARMACEUTICAL COMPOSITION AND PROCESS FOR MONTELUKAST TABLETS - The manufacture of compositions containing montelukast and to stable tablet compositions resulting thereof are disclosed, which include a first compaction step of a dry blend including, montelukast or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, and a further compression step into tablets. | 03-27-2014 |
| 20140087060 | Process For Producing A Solid Dispersion Of An Active Ingredient - A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts ( | 03-27-2014 |
| 20140106058 | TASTE MASKED ACTIVE PHARMACEUTICAL POWDER COMPOSITIONS AND PROCESSES FOR MAKING THEM - A taste masked particulate pharmaceutical formulation include a core that comprises an active pharmaceutical ingredient; at least a partial nanoparticle material layer on the core that comprises a nanoparticle material with a median particle size not greater than 100 nm; a first polymer layer that is at least partially water soluble and a second polymer layer that is water insoluble. The active pharmaceutical ingredient is completely released in 30 minutes in the USP Dissolution Test. A process of making the particulate pharmaceutical formulation using sequential fluidized bed coating steps under controlled conditions is also described. | 04-17-2014 |
| 20140106059 | SOLVENTLESS MIXING PROCESS FOR COATING PHARMACEUTICAL INGREDIENTS - The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods. | 04-17-2014 |
| 20140134320 | METHOD AND SYSTEM FOR PRINTING PERSONALIZED MEDICATION - An exemplary method of printing medications on digestible substrates is described. Single component nonmagnetic toners with active pharmaceutical ingredients (API) embedded or “dissolved” in the toner are used. The binders for the toner are digestible. The “printing” process includes loading the single component non-magnetic toners from a sump to a donor roll and developing them either directly onto the substrate or through the use of an intermediate member. Traditional xerographic charge and exposure can be used to make the tablet “imprints”. Dosage is controlled through “solid area” or halftone development (when charge and exposure are used). The “printed” first layer may undergo cold or warm pressure fusing. This medicament layer is then subjected to another station to “print” a second layer of medical “tablet”. Multiple stations may be used to build up a complete personalized tablet. Optionally, a final station prints protective overcoat materials to finalize the “tablet”. | 05-15-2014 |
| 20140212572 | PHARMACEUTICAL COMPOSITIONS FOR THE COORDINATED DELIVERY OF NSAIDS - The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages. | 07-31-2014 |
| 20140242256 | NANO-ENCAPSULATED, CONTROLLED DRUG DELIVERY, MANUFACTURING PROCESS AND SYSTEM - A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one layer of a protective material having the same core drug or different core drug. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one shell of a protective material with same drug concentration or different drug concentrations. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated such that to have different release schedule than the other portions of the drug. Methods and systems for the manufacturing and the administration of nanosized encapsulated drugs are also provided. | 08-28-2014 |
| 20140248416 | Apparatus and Method for Producing Controlled Dosage of Bioactive Agent - An apparatus for producing a controlled dosage of bioactive agent is disclosed. The apparatus includes: a print device to eject a drop of a mixture onto an ingestible substrate, wherein the drop of mixture includes a bioactive agent within an ingestible carrier fluid and is between 50 ng and 1000 ng in size; a charge generating device adjacent to the print device to generate charge on the bioactive agent to draw the bioactive agent to the ingestible substrate; a cold fluid removal device adjacent to the charge generating device to remove a portion of the ingestible carrier fluid from the bioactive agent; an application device adjacent to the cold fluid removal device to apply an ingestible layer on top of the ingestible substrate encapsulating the bioactive agent or to fold the ingestible substrate on top of the bioactive agent encapsulating the bioactive agent; and a transfer device adjacent to the print device, the charge generating is device, the cold fluid removal device, and the application device to move the ingestible substrate from one device to the next. | 09-04-2014 |
| 20140272099 | Method for Producing and Monitoring Oral Active Ingredient Films - Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution. | 09-18-2014 |
| 20140322429 | Device and Method for Monitoring a Property of a Coating of a Solid Dosage Form During a Coating Process Forming the Coating of the Solid Dosage Form - A method and a device for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form are provided. The device comprises a coating apparatus configured for forming the coating on the solid dosage form, and a monitoring apparatus configured for monitoring the property of the coating of the solid dosage form in process, wherein at least a part of the monitoring apparatus is located so as to have insight in an interior of the coating apparatus, the interior accommodating the solid dosage form to be coated and a precursor for forming the coating, and wherein the monitoring apparatus is configured for monitoring the property of the coating of the solid dosage form simultaneously with and during a coating process using low coherence interferometry. | 10-30-2014 |
| 20150050416 | Coated Solid Dosage Forms - The invention is associated with ingestible film coated solid dosage forms comprising natural honey in the coating applied to such forms. The natural honey of the film coated solid dosage form is of sufficient level to be perceived by the user while avoiding sticking to each other or the packaging with which they are in contact and, or storage. | 02-19-2015 |
| 20150099055 | COATED MICROBUBBLES - The present invention relates to methods and apparatus to provide coated microbubbles, particularly but not exclusively microbubbles at least partially coated with a component, for example a clinically active component. Systems of the present invention use electromagnetic fields to move microbubbles between streams of liquids in order to perform coating or washing steps. | 04-09-2015 |
| 20150125590 | System and Method for Continuous Polymer Coating of Particles - The present disclosure relates to the field of polymer coating. The present disclosure provides improved systems and methods for continuous polymer coating of particles (e.g., nanoparticles). The present disclosure provides for a solid hollow fiber cooling crystallization (SHFCC) technique to continuously coat the nanoparticles with polymer. In certain embodiments, the present disclosure embraces continuous coating of particles from about 1 nm to about 10 microns. A polymer solution containing a suspension of submicron particles flows in the lumen of a solid polymeric hollow fiber, and controlled cooling of the polymer solution allows for polymer nucleation on the surface of the particles, and the precipitated polymer forms a thin film around the particles (the thickness of which can be varied depending on the operating conditions). The systems, methods and assemblies of the present disclosure are easily adaptable for coating nano-sized drug particles as well. | 05-07-2015 |
| 20150352568 | WURSTER ACCELERATOR WITH POWDER APPLICATOR - A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder. | 12-10-2015 |
| 20160113884 | Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs - The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor. | 04-28-2016 |
| 20160120808 | 3D Printing of Digestible Shells For Medicaments - A method for producing edible medications comprises providing a three-dimensional (3D) model of the edible medication including an internal cavity sized and shaped for receipt of a medicament therein, printing an edible media to form a portion of the 3D shell corresponding to the model for introduction of the medicament, and then printing the edible media to form the remainder of the 3D shell to completely enclose the medicament within the edible media. | 05-05-2016 |
| 20160166512 | Porous Hollow Fiber Anti-Solvent Crystallization-Based Continuous Method of Polymer Coating on Submicron and Nanoparticles | 06-16-2016 |
| 20160250232 | A DELAYED RELEASE DRUG FORMULATION | 09-01-2016 |
| 20170232667 | PROCESS FOR MAKING CONTROLLED RELEASE MEDICAL IMPLANT AND NON-IMPLANT PRODUCTS | 08-17-2017 |
