| Entries |
| Document | Title | Date |
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| 20080199534 | Stability in vitamin and mineral supplements - The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and/or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition. | 08-21-2008 |
| 20080220086 | Injectable Composite Material Suitable for Use as a Bone Substitute - The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material. | 09-11-2008 |
| 20080226745 | Products Containing Highly Unsaturated Fatty Acids for Use by Women During Stages of Preconception, Pregnancy and Lactation/Post-Partum - A method and product for improving maternal and child health through nutrition. Omega-6 fatty acid and/or omega-3 fatty acid are provided to a woman and/or child prior to, during and/or after pregnancy to improve the health of the woman and her child. The ratios of the omega-6 and omega-3 fatty acids vary during various stages, e.g., pre-pregnancy, pregnancy and post-pregnancy. The omega-6 and omega-3 fatty acids can be in a variety of forms, such as at least one of highly purified algal oil comprising 70% by weight or more of the desired HUFA, triglyceride oil combined with phospholipid, phospholipid, protein and phospholipid combination, or dried marine microalgae. | 09-18-2008 |
| 20090022811 | Mineralized guided bone regeneration membranes and methods of making the same - The present invention provides a method for mineralizing commercially available guided bone regeneration membranes. The method comprises the steps of (a) providing a commercially available guided bone regeneration membrane, (b) applying a mineralizing solution, and (c) microwaving the membrane. The method may further comprise (d) rinsing the membrane in a solution such as distilled water and (e) drying the membrane. The mineralizing solution may be a solution capable of supplying or delivering a mineral such as calcium or zinc. The invention further provides guided bone regeneration membranes made by the methods described. The guided bone regeneration membrane comprises a mineral, such as, for instance calcium or zinc at a weight percent of at least 5%, at least 10%, at least 12%, at least 15%, at least 18%, at least 20% or at least 25% (weight percent) of the membrane. Further, the invention provides methods for enhancing bone regeneration and methods for inhibiting bacterial infection and inflammation. | 01-22-2009 |
| 20090028960 | CALCIUM PHOSPHATE-BASED ADHESIVE FORMULATION FOR BONE FILLING - The present invention relates to a calcium phosphate-based formulation for bone filling, comprising at least one adjuvant giving adhesion properties, said at least one adjuvant can be selected from the saccharide head surfactant group. | 01-29-2009 |
| 20090047362 | Method for in-vitro stabilization of heavy metals - This invention provides a method for reducing the level of 1.0 Normal HCL soluble heavy metals within the human stomach acid environment by oral ingestion of stabilizing agents such that the heavy metal solubility is reduced and subsequent heavy metal transfer to the blood stream is reduced to acceptable levels or eliminated. | 02-19-2009 |
| 20090110748 | Biocompatible Material and Process for Manufacturing the Same - In order to provide a biocompatible material consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen, which is adjusted so that easily digested and absorbed in a human body, the material contains a composite consisting mainly of a fish scale-derived hydroxyapatite and a fish scale-derived collagen. | 04-30-2009 |
| 20090130222 | Methods for Predicting Urine Ph - The invention provides methods for predicting urine pH for an animal by determining the amount of selected cations, anions, and sulfur-containing amino acids in a food for consumption by the animal and predicting urine pH using a formula that equates the amount of such cations, anions, and sulfur-containing amino acids to urine pH. Generally, the amounts of all or a subset of the cations sodium, potassium, calcium, and magnesium; the anions are chloride, sulfur, and phosphorus; and the sulfur-containing amino acids methionine and cystine in a food are used to predict animal urine pH when the food is consumed by the animal. | 05-21-2009 |
| 20090136589 | METHODS FOR SEALING FLUID LEAKS IN LUNG TISSUE - A method for reducing leakage of bodily fluids or air through lung tissue within a patient is provided. In one embodiment, the method comprises applying, to an appropriate area of lung tissue, an adhesive composition that is derived from a mixture of KH | 05-28-2009 |
| 20090155379 | Nutritional composition for facilitating muscle pumps - A composition for providing a method for creating and prolonging muscle pumps, providing a transducer effect for nitric oxide, increasing nutrient delivery and promoting increased vascular response in individuals. The composition of the present invention comprises citrulline, aspartic acid and creatine. In addition, the nutritional composition may also comprise L-arginine, and maritime pine (bark) extract. The nutritional composition of the present invention may also further comprise L-leucine and L-valine. | 06-18-2009 |
| 20090175955 | HYDROPEROXYLAPATITE AND COMPOSITIONS THEREOF - This invention relates to a compound of general formula Ca | 07-09-2009 |
| 20090208589 | NOVEL HYDROPHILIC POLYMERS AS MEDICAL LUBRICANTS AND GELS - The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery. | 08-20-2009 |
| 20090238893 | NUTRITIONAL FORMULATION - A nutritional formulation for the treatment of inflammatory conditions of the gastrointestinal tract (particularly Crohn's Disease in paediatric patients) comprises: (a) a lipid source, (b) a carbohydrate source, and (c) a protein source. wherein the lipid source comprises a weight ratio of n-6:n-3 fatty acids of 1:1 to 3:1, at least 90% by weight of the n-3 fatty acids in the lipid source are provided by α-linolenic acid and at least 90% by weight of the n-6 fatty acids in the lipid source are provided by linoleic acid and components (a), (b) and (c) together provide at least 400 kcal of energy per 100 g total weight of (a)-(c). | 09-24-2009 |
| 20090263497 | PRODUCTION METHOD FOR CALCIUM PHOSPHATE NANO-PARTICLES WITH HIGH PURITY AND THEIR USE - The present invention provides a continuous process for producing calcium phosphate nanoparticles in a network mixer or static mixer reactor, fed by a calcium solution, a phosphorous solution and an alkaline solution and, optionally, one solvent or dispersing agent. The proposed process enables the micromixing control, which is essential to form nanometric structures, but it is also a determining factor in the crystals purity, crystallinity and morphology. The reactants distribution scheme at the inlet of the reactor and along the reactor, performed continuously or varying in time, is also a crucial factor to programme the pH of the reactant media along the reactor The calcium phosphate nanoparticles suspension that exits the reactor can be submitted to further aging, ultra-sounds, separation, drying, sintering and milling processes. Some calcium phosphates are considered biomaterials, used as: food additives and nutritional supplements; bone graft for bone replacement, growth and repair; biocements and coating of metallic implant. Some of the most recent applications include their use in cosmetics, toothpaste and in esthetical treatments for diminishing wrinkles by stimulating conjunctive tissue formation. | 10-22-2009 |
| 20100003340 | COSMETIC COMPOSITIONS FOR THE TREATMENT OF SKIN AND METHODS THEREOF - A cosmetic composition comprising at least one compound selected from bioactive/biocompatible microparticulates such as bioactive glass or bioactive ceramics, and an intradermal delivery vehicle selected from the group consisting of hyaluronans, hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid in an amount sufficient to facilitate deposition and penetration of said bioactive microparticulates through tissue at a site to be treated | 01-07-2010 |
| 20100015244 | Nano/Macroporous Bioactive Glasses Made by Melt-Quench Methods - The methods and materials described herein provide novel and simple procedures for the preparation of nano/macroporous glasses, in which the pore structure is characterized by interconnected pores of, e.g. both hundreds of micrometers and several to tens of nanometers in size. Such materials may be used for enhanced bone regeneration, bioscaffolds, drug delivery devices, and filtration media, among other uses. For example, silica-based bone tissue scaffolds are made with a controlled nano/macroporosity, which enhances bone regeneration performance. Also provided herein are new biocompatible CaO—Na | 01-21-2010 |
| 20100086619 | Dietary supplement containing strontium (M) ascorbate, compositions containing same, method for making same and method for using same - A formulation including a compound of formula (ascorbate) | 04-08-2010 |
| 20100086620 | Bone Cement Composition and Method of Making the Same - Disclosed herein is a composition suitable for use in spinal surgery. The composition generally includes a reaction product or settable mixture of first and second components, the first component including a spray-dried inorganic filler, a radical donor, and a pre-polymerized vinyl polymer, and the second component including a radical scavenger, a diluent, a polymerization accelerator, and a reactive monomer. Furthermore, disclosed herein is a method of making the composition, which generally includes mixing the first and second components under conditions suitable to form a curable reaction product. | 04-08-2010 |
| 20100092573 | HEMOSTATIC BIO-MATERIAL COMPOSITION AND METHOD - The present invention relates to a haemostatic bio-material composition and method for achieving hemostasis. The method for providing hemostasis generally comprises: supplying a dry potassium phosphate based hemostat mixture comprising: monobasic potassium phosphate, a metal oxide, and a tertiary calcium phosphate, wherein the weight percent ratio of monobasic potassium phosphate to metal oxide is between about 3:1 and 1:1; mixing the dry potassium phosphate based hemostat mixture with an aqueous solution forming an activated hemostat slurry; applying an hemostasis-promoting amount of the activated potassium phosphate based hemostat slurry to a site of bleeding; wherein the site of bleeding is in, on, or proximate to bone. | 04-15-2010 |
| 20100119617 | MULTI-NUTRIENT MILK FORTIFIER - A multi-nutrient fortifier Total Randomized for supplementing breastfed infants is provided. The fortifier can be sterilized and can be formulated for delivery after hospital discharge. The fortifier is designed to supplement infants to meet the specific needs such as maintaining appropriate and safe levels of fat soluble vitamins and minerals, to incorporate vitamins normally requiring additional supplementation, such as vitamins A, D, E or iron for breastfed infants, to facilitate delivery of calcium and phosphorous salts. According to an embodiment of the invention, the fortifier can be in a concentrated liquid form, is sterile, and delivers greater than about 44% protein, by weight, and greater than about 17% protein, by weight, when analyzed in combination with breast milk. The fortifier can be used to improve growth and body composition of a breastfed infant post hospital discharge, such as a low birth weight infant, a post-surgical infant, or an ill term-born infant. | 05-13-2010 |
| 20100129465 | Methods and Compositions Related to Acne Treatment - Disclosed herein are methods and compositions for treating acne using a composition comprising a large amount of naturally occurring minerals. | 05-27-2010 |
| 20100136131 | COMPOSITE MATERIAL - The present invention provides a composite material comprising fibrinogen or fibrin, or a mixture thereof, and a bioactive glass. The invention also relates to wound dressings and pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial infections in a wound, preventing or alleviating bleeding in a wound, sterilising a wound, controlling haemorrhaging, increasing the rate of coagulation of blood and/or activating a coagulation system in a wound. | 06-03-2010 |
| 20100143490 | COMPOSITE MATERIAL - The present invention provides a composite material comprising lactoferrin and a bioactive glass. The invention also relates to pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial or viral infections in a wound, preventing viral transmission, regenerating bone, treating osteoporosis, preventing or alleviating bleeding in a wound, sterilising a wound and/or controlling haemorrhaging. | 06-10-2010 |
| 20100173009 | SILICATE-SUBSTITUTED HYDROXYAPATITE - An inorganic silicate-substituted calcium phosphate hydroxyapatite, useful as a biomaterial, has a Ca/P molar ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. The hydroxyapatite can be substantially free of carbonate ions. The material has relatively high solubility and is able to release silicon into solution. | 07-08-2010 |
| 20100183736 | REHYDRATION BEVERAGE - The present invention relates to a composition for the relief of hangover symptoms and methods of treating hangover symptoms. | 07-22-2010 |
| 20100196500 | ANHYDROUS DICALCIUM PHOSPHATE PARTICLES AND PRODUCTION METHOD THEREOF - The present invention provides anhydrous dicalcium phosphate particles which satisfies the conflicting requirements of the improvement of handling properties such as high flowability and a small bulk and the improvement of tableting properties at the same time during preparation and a method of producing the same. | 08-05-2010 |
| 20100272826 | NANO/MACROPOROUS BONE TISSUE SCAFFOLDS FOR REGENERATIVE MEDICINE - A biocompatible inorganic porous material having a three-dimensional coexistent network of interconnected macro-pores and nanopores produced by the steps of mixing an organic water-soluble polymer (e.g., polyethylene oxide or a block copolymer of ethylene oxide and propylene oxide), an alkoxysilane, and an inorganic water-soluble calcium salt in an aqueous acid solution, such that a sol-gel process of hydrolysis and polycondensation is initiated and thereby producing a gel; drying the gel to remove solvent by evaporation; and heating the gel to remove the polymer by thermal decomposition, thereby forming an inorganic porous material, which may be suitable for use as a bone tissue scaffold. | 10-28-2010 |
| 20100303925 | REMINERALISATION OF CALCIFIED TISSUE - The disclosure concerns cosmetic and therapeutic treatment of tissue, such as tooth, to effect, for instance, whitening and tissue re-building through mineralisation and including kits for use in the methods. | 12-02-2010 |
| 20110008460 | BIOMIMETIC HYDROXYAPATITE COMPOSITE MATERIALS AND METHODS FOR THE PREPARATION THEREOF - The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith. | 01-13-2011 |
| 20110027381 | TREATMENT OF OSTEOPOROSIS - The present invention relates to a combination for the treatment of osteoporosis and/or the prophylaxis and treatment of bone fractures, said combination comprising collagen, an additional peptide, a calcium-containing substance and a wetting agent with a terminally functionalized oligolactone. The invention also relates to artificial bones and implants produced by the combination and to the use of said combination for fixing implants and treating osteoporosis and/or the prophylaxis and treatment of bone fractures. The invention further relates to a method for producing artificial bones and implants. | 02-03-2011 |
| 20110038948 | Methods of Reducing the Production of Reactive Oxygen Species and Methods of Screening or Identifying Compounds and Compositions that Reduce the Production of Reactive Oxygen Species - The subject application provides methods of identifying compounds, combinations of compounds, compositions, and/or combinations of compositions that are suitable for reducing the production of reactive oxygen species (ROS) in an individual with the proviso that said compound, combination of compounds, composition, or combination of compositions is not a dietary material containing calcium or dietary calcium. Also provided in the subject application are methods of treating diseases or disorders associated with ROS production and methods of reducing ROS production in an individual with the proviso that said compound, combination of compounds, composition, or combination of compositions is not a dietary material containing calcium or dietary calcium. | 02-17-2011 |
| 20110038949 | HOMEOPATHIC FORMULATION - The present invention relates to homeopathic formulations comprising at least Causticum, Natrium muriaticum and a Solanaceae (e.g. | 02-17-2011 |
| 20110086108 | Dissolving powders that can be mixed with water and used as an oral rinse - This invention involves the formulation of stable powders which, when dissolved in water form a non-pressurized carbonated solution supersaturated with calcium and phosphate ions, and also containing the presence of carbon dioxide and sodium bicarbonate. The resulting solution is used as an oral rinse for the prevention and treatment of inflammatory processes of the soft tissues of the mouth, throat and oral cavity, which may result from infection or trauma to the oral mucosal tissue. | 04-14-2011 |
| 20110129544 | Bone/Cartilage Formation-Stimulation Agent - Disclosed is a mixture of: a bone/cartilage formation promoting agent containing sulfated galactosaminoglycan having greater than or equal to 0.6 numbers of ester sulfate groups on average per constituent monosaccharide or a salt thereof as an active ingredient; a factor having a bone/cartilage formation promoting action; or a bone filler (BMP, TGF-β, FGF, IGF, insulin, PDGF, HGF, midkine, pleiotrophin, collagen, gelatin, proteoglycan, fibronectin, osteocalcin, osteopontin, osteonectin, bone sialoprotein, hydroxyapatite, dicalcium phosphate anhydride, dicalcium phosphate dehydrate, α-tricalcium phosphate, amorphous calcium phosphate, octacalcium phosphate, β-tricalcium phosphate, PLLA, PLGA, titanium, decalcified bone, autogeneous bone, or the like). | 06-02-2011 |
| 20110135750 | ANTI-ALLERGEN COMBINATIONS OF CALCIUM AND LANTHANUM - The present invention relates to certain combinations of alkaline earth metal salts and rare earth metal salts which provide an improved denaturing effect on allergens. More particularly, the present invention relates to compositions comprising a combination of calcium salts and lanthanum salts in respective proportions to produce a synergistic denaturing effect on allergens. Compositions comprising these combinations are particularly effective for use in an ex vivo method for denaturing allergens associated with house dust mites and other common allergens such as cat dander, molds, cockroach, pollen and the like. | 06-09-2011 |
| 20110171319 | NUTRITIONAL COMPOSITION MADE USING ISOLATED ORGANIC MATTER - Nutritional compositions, formulations, and intermediates are provided which may be utilized to formulate various sweeteners and other products. The formulations described herein are made from constituents found in soils or fossilized soils. | 07-14-2011 |
| 20110212186 | COMPOSITION FOR TREATING AUTOIMMUNE DISORDERS - The present invention relates to a composition, use and a method for reducing inflammation and promoting tissue repair or tissue regeneration through a synergistic effect of T-ChOS and Glucosamine and/or N-acetyl glucosamine systemically or locally administered in humans and other mammals in need thereof. | 09-01-2011 |
| 20110217388 | DEVICES AND METHODS FOR THE REGENERATION OF BONY DEFECTS - This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles. | 09-08-2011 |
| 20110250289 | BONE SUBSTITUTE AND METHOD FOR THE PREPARATION THEREOF - The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm | 10-13-2011 |
| 20110268815 | TEMPERATURE-INSENSITIVE CALCIUM PHOSPHATE CEMENTS - Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures. | 11-03-2011 |
| 20110280955 | Nutritional Supplements For 50+ Individuals For Improving Vitality, Immunity, Eye And Bone Health - A nutritional supplement for adults fifty years and older, and methods of use thereof, are provided that are designed to be most effective in optimizing health, improving vitality and immunity, and improving, aiding, eye and bone health. | 11-17-2011 |
| 20110293740 | TREATMENT SYSTEM AND METHOD FOR OSTEOPENIA AND OSTEOPOROSIS USING NON-SYNTHETIC BIO-AVAILABLE COMPOUNDS - A treatment system and method for osteopenia and osteoporosis using non-synthetic bio-available hormones, vitamins, minerals, and agents may be customized by varying the dosage and formulation of the components to maximize therapeutic effect, bioavailability, and patient comfort and compliance with their treatment method, the treatment system including a storage unit including a determined number of applications of hormones, minerals, and vitamins of appropriate dosages for treating the patient with osteopenia and osteoporosis. | 12-01-2011 |
| 20110311643 | SUPPLEMENTED MATRICES FOR THE REPAIR OF BONE FRACTURES - Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, which are used to heal bone fractures, particularly bone fractures with a risk of becoming delayed unions or non-unions, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible, preferably biodegradable, and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated in the matrix. | 12-22-2011 |
| 20110311644 | Plasma-Adapted Full Electrolyte Solution - The present invention describes a balanced aqueous electrolyte solution. In particular, a balanced aqueous electrolyte solution that is particularly suitable as a solution for intravenous and subcutaneous infusion because of its being plasma-adapted is described. In addition to the balanced electrolyte solution itself, an electrolyte mixture as well as a process for preparing the balanced electrolyte solution from this mixture, and a medicament comprising the solution and optionally an active ingredient are provided. | 12-22-2011 |
| 20120021063 | CROSSLINKED MATERIAL COMPRISING ELASTIN AND COLLAGEN, AND USE THEREOF - To provide a collagen/elastin crosslinked material capable of satisfactorily corresponding to various uses such as medical materials including an artificial dermis and scaffolding materials for cell culture. The collagen/elastin crosslinked material is obtained by crosslinking a fish-derived collagen and a fish-derived elastin, and is fully capable of corresponding to various uses such as medical materials including an artificial dermis and scaffold material for cell culture. | 01-26-2012 |
| 20120040014 | LIPID Supplements for Maintaining Health and Treatment of Acute and Chronic Disorders - Nutritional supplement formulations suitable for specific enhancement of cell and mitochondrial function comprise enriched formulations of phospholipids and chemical precursors containing specifically identified concentrations of phosphatidylglycerol, phosphatidic acid and phosphatidylcholine, and mitochondrial and cell membrane phospholipid molecules as well as other desirable constituents. Methods of enriching extracted sources of cell and mitochondrial membrane molecules and precursors from microbes, plants and other sources are also set forth. The formulae can be combined with nutritional, prebiotic, and probiotic (microbial) factors that increase bioavailability through the digestive tract and increase absorption at the cellular and subcellular levels. These lipid combinations can be used to treat mitochondrial disorders associated with medical pathologies, chronic illnesses and syndromes, or to maintain lipid balance for normal mitochondrial function, and can be administered in many different forms. The various combinations specifically enriched in the correct phospholipid and correct fatty acid residues can be used to treat organ, tissue, cell or system. | 02-16-2012 |
| 20120040015 | BIOCOMPATIBLE COMPOSITE AND ITS USE - A composite material including biocompatible and bioresorbable glass, a biocompatible and bioresorbable matrix polymer and a coupling agent capable of forming covalent bonds. The composite also includes a compatibilizer, where at least 10% of the structural units of the compatibilizer are identical to the structural units of the matrix polymer, and the molecular weight of the compatibilizer is less than 30000 g/mol. The use of this composite, a medical device which includes the composite and a method for preparing the composite are also disclosed. | 02-16-2012 |
| 20120058198 | METHODS FOR TREATING AND PREVENTING PNEUMONIA AND VENTILATOR-ASSOCIATED TRACHEOBRONCHITIS - The invention relates to methods for treating bacterial infection of the respiratory tract, including pneumonias, such as ventilator-associated pneumonia, and to methods for treating ventilator-associated tracheobronchitis, comprising administering an effective amount of a salt formulation as an aerosol to the respiratory tract of an individual in need thereof. The formulations can also be used to reduce transmission of pathogen which can infect the respiratory tract, cause pneumonia or cause ventilator-associated tracheobronchitis. | 03-08-2012 |
| 20120064170 | Gallium-Doped Phosphocalcic Compounds - The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca | 03-15-2012 |
| 20120076870 | BONE SUBSTITUTE AND METHOD FOR THE PREPARATION THEREOF - The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm | 03-29-2012 |
| 20120107414 | PHARMACEUTICAL FORMULATIONS AND METHODS FOR TREATING RESPIRATORY TRACT INFECTIONS - The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Ca | 05-03-2012 |
| 20120114763 | Method for Producing Collagen/Apatite Composite Membrane for Guided Bone Regeneration - Disclosed is a method for producing a collagen/apatite composite membrane useful as a barrier to protect fibrous connective tissues from infiltrating into a site of defective tissue or bone in guided tissue regeneration (GTR) or guided bone regeneration (GBR) procedures. Such composite membrane can be obtained by the steps of co-precipitating collagen and apatite in aqueous basic solution in a very well controlled manner, followed by casting the precipitation onto a filter paper, lyophilization and cross-linking. The method according to the present invention can allow forming a collagen/apatite composite membrane in which the crystals of apatite, in particular, hydroxyapatite are coated on and along with the collagen fiber direction without aggregation of self-assembled collagen fibers. Such composite membrane has excellent biological and mechanical properties such as biocompatibility, cell affinity, biodegradability and form stability, and therefore it can be used as a barrier for GTR. The method of the present invention can also allow the composite membrane to have microstructure enabling osteoblasts to be attached and proliferated well on the membrane, and can allow the properties of membrane to be controlled by adjusting its thickness in the formation of membrane, thereby providing a collagen/apatite composite membrane suitable to a needed use. | 05-10-2012 |
| 20120128788 | COLLAGEN PRODUCTION ENHANCER - A collagen production enhancer for increasing the amount of collagen contained in the skin tissues, comprising calcium phosphate fine particles as effective ingredients. | 05-24-2012 |
| 20120135086 | METHOD OF TISSUE REPAIR USING A COMPOSITE MATERIAL - A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding. | 05-31-2012 |
| 20120141596 | Multi-Purpose Bio-Material Composition - The present invention relates to a multi-purpose bio-material. One preferred embodiment of the present invention generally comprises KH | 06-07-2012 |
| 20120156308 | MINERAL TRIOXIDE AGGREGATE (MTA) COMPOSITION AND USE - The present application discloses a fast-setting mineral trioxide aggregate (MTA) with fluoride release for practical treatment of diseases in teeth and bone, e.g. for caries treatment and/or prevention. The cariostatic MTA contain calcia-silica-alumina cement with moderately increased tricalcium aluminate content allowing high calcium hydroxide release. The MTA composition support remineralization and biomineralization, and it is suitable for stimulation of hard tissue regeneration. MTA embodiments contain superplasticizerand nanosilicate for improved mechanical properties. The MTA compositions include optional radiocontrast and nano-enriched leachable fluorine, nitrate, strontium, and phosphate. The fast-setting MTA paste exhibits flow-to-clay-like consistency, which allows new practical applications including cavity lining, temporary restoration, bonding, and cementations in one MTA embodiment. The high calcium hydroxide and high fluoride release are suitable for caries prevention and treatment, and per se inhibition of dental symptoms. | 06-21-2012 |
| 20120177744 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE TREATMENT OF CANCER - Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines. | 07-12-2012 |
| 20120183625 | METHOD FOR PREPARING AQUEOUS SOLUTION OF HIGH-CONCENTRATION CALCIUM PHOSPHATE STABLE IN NEUTRAL PH RANGE - Disclosed herein is a method for preparing an aqueous solution of high-concentration calcium phosphate, the method comprising the steps of: preparing an acidic aqueous solution using an acidic chelating agent; and dissolving a calcium phosphate-based compound in the acidic aqueous solution, and then adding a pH-adjusting agent to the acidic aqueous solution to adjust the pH of the acidic aqueous solution. The disclosed aqueous solution does not form a precipitate after neutralization so that it can be used in various calcium-containing products, including foods, drugs, or quasi-drugs. | 07-19-2012 |
| 20120189709 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO TREAT A CONDITION - Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines. | 07-26-2012 |
| 20120251626 | PROCESS FOR MANUFACTURING BIOCOMPATIBLE MATERIAL - A process for producing a biocompatible material includes the steps of mixing an extract of a fish scale-derived hydroxyapatite (with water content of 70 to 75% by weight) and of a fish scale-derived collagen (with water content of 40 to 60% by weight) in the weight percent ratio of about 8:2, stirring the mixture and drying the mixture by a hot blast in order to obtain a composite. | 10-04-2012 |
| 20120263797 | IMPLANTABLE POLYMER FOR BONE AND VASCULAR LESIONS - A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures. | 10-18-2012 |
| 20120294954 | COMPOSITIONS INCLUDING GINGER FOR THE AMELIORATION OR PREVENTION OF INFLAMMATORY CONDITIONS - The invention encompasses pet food compositions for a companion animal that include ginger and methods for enhancing the quality of life of an animal by administering such pet food compositions in the diet of the animal. | 11-22-2012 |
| 20130059011 | BIOACTIVE BONE GRAFT SUBSTITUTE - The invention relates to biocompatible bone graft materials for repairing bone defects and the application of such bone graft materials. | 03-07-2013 |
| 20130059012 | Methods for the Diagnosis, Control and Prophylaxis of Inflammation and Mitigation of Inflammatory Conditions in Felines - The invention relates to methods of diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions, particularly arthritis and joint pain, in felines, comprising measuring particular inflammatory biomarkers. The invention further provides a method to treat or control inflammation comprising administering a diet comprising increased levels of one or more of DHA, EPA, methionine, manganese, vitamin C, vitamin E, and/or L-carnitine. | 03-07-2013 |
| 20130059013 | INJECTABLE OSTEOINDUCTIVE BONE CEMENTS - An injectable composition for bone filling or consolidation, for use in surgery or therapy, characterized in that it comprises a biocompatible powdery material, which is hardenable or cross-linkable and selected from calcium sulphate hemi-hydrate and polymethylmethacrylate, a hardening or cross-linking agent for said material and a porous silica-based powdery material, having a specific surface area higher than 100 m | 03-07-2013 |
| 20130078316 | METHODS AND COMPOSITIONS FOR IRRIGATION OF MUCOSAL TISSUES - A synthetic endotracheal irrigant for preventing, treating, and reducing infections, including mucosal infections in patients, including infants. A method for producing a formulation of the synthetic endotracheal irrigant with a water content of about 98% (w/w) to about 99.9(w/w) and a total mineral content of less than about 5.0% (w/w), including a sodium content of less than about 2.0% (w/w). The synthetic endotracheal irrigant excludes protein. | 03-28-2013 |
| 20130101676 | BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS - The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer. | 04-25-2013 |
| 20130136800 | Enteral Or Oral Food Product Intended, In Particular, For nutrition And For The Prevention And Improvement Of Neurological Alterations, Neurodegenerative Alterations or Cognitive Disorders - The present invention relates to a complete food product for specific nutritional use, especially intended for enteral or oral nutrition of patients who suffer neurological or neurodegenerative alterations, and for the prevention of cognitive or behaviour disorders, especially in the case of elderly persons, such food product comprising a functional ingredient especially conceived for the nourishment of patients suffering from, or prone to neurological or neurodegenerative alterations, cognitive deterioration or behaviour disorders, as well as a mixture of carbohydrates, a mixture of proteins, a mixture of lipids and dietary fibre, inulin, vitamins and minerals. | 05-30-2013 |
| 20130177656 | COMPOSITE MATERIAL COMPRISING PECTIN AND CALCIUM PHOSPHATE AND METHOD FOR ITS REALISATION - A method for obtaining a composite material including an aqueous solution of pectin and a suspension/solution of calcium phosphate mixed together, wherein said solution of pectin cross-links with a portion of the calcium obtained from the solution of calcium phosphate and wherein a portion of the calcium phosphate in suspension remains as inorganic phase and composite materials obtained by this method. | 07-11-2013 |
| 20130216629 | BIO-MATERIAL COMPOSITION AND METHOD FOR SPINAL FUSION - The present invention relates to a material and method for providing spinal fusion. One preferred method comprises: accessing the intervertebral space defined between adjacent vertebrae; mixing magnesia, potassium biphosphate, and a calcium phosphate with an aqueous solution forming an activated spinal fusion slurry (ASFS); applying an effective amount of the ASFS to the intervertebral space between adjacent vertebrae; allowing the ASFS to set forming a bonded vertebrae structure; permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae. | 08-22-2013 |
| 20130216630 | BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY - This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials pre-loaded with certain amounts of osteoclastic activity inhibitors for use in methods to control and/or induce bone growth in primates. | 08-22-2013 |
| 20130295193 | Antibacterial calcium-based materials - A preparation at least useful as a bone implant is provided, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound. | 11-07-2013 |
| 20130295194 | PRODUCTION OF MOLDABLE BONE SUBSTITUTE - Composites and methods of producing a mouldable bone substitute are described, A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability. | 11-07-2013 |
| 20130316015 | Methods for Repairing Cartilage - The invention relates to compositions, dosage forms and methods for stimulating cartilage growth, regeneration or repair, and treating cartilage defects and diseases using short chain polyphosphates, in particular polyphosphates having a chain length of greater than 5 phosphate units. The compositions, dosage forms and methods have particular application in the treatment of osteoarthritis. | 11-28-2013 |
| 20130337082 | NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO - This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a Noggin blocker. | 12-19-2013 |
| 20130344165 | JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO - This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker. | 12-26-2013 |
| 20140004207 | Analgesic Apatitic Calcium-Phosphate Cement | 01-02-2014 |
| 20140023725 | Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio - The biocompatible, biodegradable materials in the solid and/or liquid form are based on segmented linear polyurethanes and/or segmented crosslinked polyurethanes based on A) one or more biocompatible polyols susceptible to hydrolytic and/or enzymatic degradation having a molecular weight of 100 to 20,000 dalton and a number of active hydroxyl groups per molecule (functionality) of at least two or higher; B) one or more diisocyanates and/or triisocyanates; and C) one or more low molecular weight chain extenders having a molecular weight of 18 to 1000 dalton and the functionality of at least two or higher. | 01-23-2014 |
| 20140087004 | Gallium-doped phosphocalcic compounds - The present invention relates to a gallium-doped phosphocalcic compound of formula (I): | 03-27-2014 |
| 20140120177 | HYDROPHILIC INTERPENETRATING POLYMER NETWORKS DERIVED FROM HYDROPHOBIC POLYMERS - A composition of matter comprising a water-swellable IPN or semi-IPN including a hydrophobic thermoset or thermoplastic polymer and an ionic polymer, articles made from such composition and methods of using such articles. The invention also includes a process for producing a water-swellable IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an ionizable monomer solution in contact with a solid form of the hydrophobic thermoset or thermoplastic polymer; diffusing the ionizable monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the ionizable monomers to form a ionic polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN. | 05-01-2014 |
| 20140147512 | DENTAL MINERALIZATION - A method is provided for mineralizing a dental surface or subsurface including contacting the dental surface with a protein disrupting agent and stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP). | 05-29-2014 |
| 20140161901 | DENTAL COMPOSITION - Dental compositions are disclosed. A dental composition can include a reaction produce of a reaction mixture comprising a first mixture and a second mixture. The first mixture can include a ceramic based biomaterial, and the second mixture can include mineral trioxide aggregate and a phosphoric acid monomer. | 06-12-2014 |
| 20140170235 | BIOABSORBABLE POLYMERS - Described herein are biocompatible compositions that contain a copolymer and a filler material. In particular, described herein are compositions that include a copolymer and a filler which may be a calcium salt. Also described herein are methods in which the compositions are used to attach soft tissue to bone. | 06-19-2014 |
| 20140205676 | METHOD OF TISSUE REPAIR USING A COMPOSITE MATERIAL - A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding. | 07-24-2014 |
| 20140220151 | Stability in Vitamin and Mineral Supplements - The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and/or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition. | 08-07-2014 |
| 20140248372 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO - The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as clotrimazole, honokiol, magnolol, tacrolimus, pimecrolimus, sirolimus, everolimus, temsirolimus, spironolactone, fluticasone, fluticasone propionate, fluticasone furoate, linezolid, telmisartan, chlorambucil, retinol, isotretinoin, acitretin, etretinate, retinoic acid (tretinoin), teniposide, mitomycin C, cytarabine, decitabine, vinblastine, vincristine, vindesine, vinorelbine, valrubicin, doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxantrone, pixantrone, plicamycin, pazopanib, topotecan, camptothecin, irinotecan, sunitinib, derivatives, or salt thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. | 09-04-2014 |
| 20140271912 | SODIUM CONTAINING SOL-GEL DERIVED BIOACTIVE GLASSES AND USES THEREOF INCLUDING HEMOSTASIS - A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof which include introducing Na | 09-18-2014 |
| 20140271913 | COMPOSITIONS AND METHODS FOR MANUFACTURING SOL-GEL DERIVED BIOACTIVE BOROPHOSPHATE GLASSES FOR MEDICAL APPLICATIONS - A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof which include at least 5 weight percent CaO, at least 10 weight percent P | 09-18-2014 |
| 20140302164 | SYNTHESIS OF BIOCERAMIC COMPOSITIONS - A process for the synthesis of a bioceramic composition comprising calcium phosphosilicate (CPS, Ca | 10-09-2014 |
| 20140302165 | SODIUM CONTAINING SOL-GEL DERIVED BIOACTIVE GLASSES AND USES THEREOF INCLUDING HEMOSTASIS - A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na | 10-09-2014 |
| 20140308364 | GELATINOUS HYDROXYAPATITE-NANOCOMPOSITES - A novel nanocomposite including hydroxyapatite-gelatin bioceramic material and dopamine, wherein the dopamine undergoes an oxidative self-polymerization reaction to form the novel nanocomposite. The nanocomposite displays superior mechanical strength, elasticity, biocompatibility and forming capabilities and is targeted for bone repairs and template-assisted tissue engineering applications. In addition, improved aminosilica-based hydroxyapatite-gelatin bioceramic bioceramics are disclosed. | 10-16-2014 |
| 20140308365 | PHARMACEUTICAL COMPOSITION USEFUL FOR ADHESION PREVENTION OR HEMOSTASIS - An object of the present invention is to provide a pharmaceutical composition that has excellent water solubility, contains a gelling agent that has a gelation rate in suitable ranges, and is useful as an adhesion preventing biomedical material. Another object of the present invention is to provide a pharmaceutical composition that can demonstrate an excellent hemostatic effect. A solid pharmaceutical composition is prepared from (A) a gelling agent, (B) a salt of a divalent metal and at least one selected from the group consisting of organic acids and inorganic acids, and (C) polyethylene glycol. | 10-16-2014 |
| 20140335198 | STABLE BICARBONATE ION-CONTAINING DRUG SOLUTION - The invention relates to a stable bicarbonate ion-containing drug solution, particularly a bicarbonate-containing drug solution for dialysis in which the stability has been improved by the presence of a phosphate ion. Further, the invention relates to a drug solution for acute blood purification, particularly a dialysate and a substitution liquid for acute blood purification to be mixed before use containing the drug solution. Still further, the invention relates to a dialysate and a substitution liquid for acute blood purification to be mixed before use in which the formation of insoluble fine particles or precipitates is prevented for a long time after mixing and with which hypokalemeia and hypophosphatemia are not caused. | 11-13-2014 |
| 20140348941 | METHOD FOR MANUFACTURING BIOACTIVE GLASS AND BIOACTIVE GLASS - A method for manufacturing bioactive glass includes the steps below. A precursor and a polar solvent are mixed to form a mixed solution, in which the precursor includes a silicon precursor, a calcium precursor and a phosphorus precursor. The mixed solution is atomized to form a mixture droplet. The mixture droplet is oxidized in an environment of 500° C. to 900° C. to form the bioactive glass. | 11-27-2014 |
| 20140348942 | Treatments for Gastrointestinal Disorders - The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention. | 11-27-2014 |
| 20140348943 | BIOMEDICAL MATERIALS - The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material. | 11-27-2014 |
| 20150024063 | MULTI-PHASED, BIODEGRADABLE AND OESTEOINTEGRATIVE COMPOSITE SCAFFOLD FOR BIOLOGICAL FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE - Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types. | 01-22-2015 |
| 20150024064 | pKa Buffered Vitamin C Composition and Method - A pKa buffered vitamin C composition which includes a base alkalizer composition mixed with vitamin C (calcium ascorbate or ascorbic acid). The base alkalizer composition can be approximately 24% to 40% and the ascorbic acid or calcium ascorbate can be approximately 76% to 60% by weight of the vitamin C composition. When this vitamin C composition is orally administered to an individual (in capsule or tablet form), a rapid neutralization of his stomach acid occurs followed by a sustained pH of 6.0 to 7.5 for a thirty minute to two hour period. This allows the ingredients to be absorbed in his stomach, while preventing unpleasant reactions in his stomach. The base alkalizer composition can include the combination of a calcium carbonate carrier which acts as a mild alkalizer, an hydroxide (magnesium or potassium) which acts as a fast alkalizer, and a phosphate (dicalcium or tricalcium) which acts as a moderate alkalizer and which also maintains the pH fairly stable over a twenty to forty minute time period. | 01-22-2015 |
| 20150118321 | BIOACTIVE GLASS PREPARATION AND USE - A process of preparing a glass comprising: (a) heating a mixture of precursor chemicals to a melt temperature to form a melt, the melt being characterized in that quenching the melt at or above a threshold temperature results in a spinodal phase seperation, and quenching the melt below the threshold temperature results in a droplet phase seperation; and (b) quenching the melt at or above the threshold temperature in a preheated mold to form the glass composition having the spinodal phase seperation. | 04-30-2015 |
| 20150132404 | Equine feed for the reduction of ulcers in performance horses - A feed supplement mixture for performance horses provides a high protein nutritional supply while lowering stress experienced by the horse, reduces the onset of ulcers in the horse's digestive tract and treats ulcers in horses already afflicted with ulcers by the introduction of a quantity of thiamine to reduce stress and sodium bicarbonate to raise the ph level of the feed and the horse's stomach content. | 05-14-2015 |
| 20150140117 | BIOACTIVATED BONE SUBSTITUTE MATERIAL - The present invention generally relates to the field of bone substitute materials, and particularly to a bone substitute material that is bioactivated. More specifically, the present invention relates to a particular agent comprising citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine for use in improving or promoting osseointegration of a bone substitute material, to a bone substitute material provided with a coating of said particular agent, and to a kit for use in a method of installing a bone substitute material comprising a bone substitute material as well as citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine. | 05-21-2015 |
| 20150140118 | Injectable Calcium-Phosphate Cement Releasing A Bone Resorption Inhibitor - The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof. | 05-21-2015 |
| 20150299412 | Thiol Acrylate Nanocomposite Foams - Thiol-acrylate copolymers are disclosed that are useful, for example, as injectable biomaterials to provide both mechanical support and biological cues to stimulate bone regrowth. Composites can be formed, for example incorporating hydroxyapatite crystal inclusions into the copolymer. In one embodiment, the composite is gas-foamed with a blowing agent during or before cure to form a porous, interconnected scaffold. The synthesis employs an amine-catalyzed Michael addition co-polymerization of a poly-thiol with a poly-acrylate. The catalyst is an in situ catalyst, such as a tertiary amine moiety that is covalently bonded to one of the reactants, preferably to the poly-acrylate. The materials can rapidly co-polymerize in vivo or in vitro via catalysis by the “attached” in situ tertiary amine groups. | 10-22-2015 |
| 20150313942 | Composites of Hydroxyapatite and Calcium Carbonate and Related Methods of Preparation and use - Carbonated calcium phosphate compositions and methods of preparation, affording enhanced biophysical properties. | 11-05-2015 |
| 20150314045 | BIO-MATERIAL COPOSITION AND METHOD OF USE - The present invention relates to a bio-material composition and methods of use. Among the preferred embodiments are methods for fusing objects to bone and methods for fixing bone voids without the need for BMP-2. One or more preferred embodiments relate to methods for fusing objects (including bone, tendons, ligaments and implants) to bone using the invented bio-material composition. | 11-05-2015 |
| 20150328365 | POROUS POLYSACCHARIDE SCAFFOLD COMPRISING NANO-HYDROXYAPATITE AND USE FOR BONE FORMATION - The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors. | 11-19-2015 |
| 20150335781 | BONE PROSTHESIS MATERIAL AND METHOD FOR MANUFACTURING SAME - A bone prosthesis material that promotes calcium ion elution while retaining its effect on osteoclasts so that its binding to a bone can be achieved at an early stage. The bone prosthesis material that is composed of a plurality of β-tricalcium phosphate (β-TCP) phases containing monovalent cations in solid solution at different concentrations. Being a composite phase of β-TCP phases containing monovalent cations in solid solution at different concentrations, the bone prosthesis material promotes calcium ion elution while retaining its effect on osteoclasts, and thus enables its binding to a bone at an early stage. | 11-26-2015 |
| 20150343008 | Homeopathic formulation useful for treating neurological disorders - The present invention relates to a homeopathic formulation useful for treating neurological disorders. | 12-03-2015 |
| 20160000089 | METHOD FOR THE TREATMENT AND CONTROL OF POST-HARVEST DISEASES IN FRUITS AND VEGETABLES AND COMPOSITIONS COMPRISING NATURAL EXTRACTS AND PLANT-STRENGTHENING AND/OR FUNGICIDAL FORMULATIONS FOR USE IN SAID METHOD - The present invention relates to a method for the control and the treatment of post-harvest diseases in fruits and vegetables by means of simultaneous and combined application of (i) a first formulation, which is aqueous or in the form of an emulsifiable concentrate, which comprises a plant extract and is applied in the form of an aqueous solution and (ii) a second formulation, in the form of an emulsifiable concentrate, soluble liquid or concentrated suspension, which is applied as an aqueous solution, selected from amongst: a plant-strengthening formulation that contains at least one phosphite salt; a fungicidal formulation that contains at least one synthetic fungicide of the phosphonate family, preferably ethyl phosphonic acid salts; or a combination thereof. Each formulation may be a different composition or form part of a single composition. A further subject matter of the present invention is therefore said composition for post-harvest protection of fruits and vegetables which is constituted by the combination of the aforementioned components. | 01-07-2016 |
| 20160015056 | Methods And Compositions for Animal Feed - The present invention is directed to methods and compositions that are useful in producing, feeding and growing animals. Compositions of the present invention comprise an extracted mineral element composition as disclosed herein. Animal lifespan and production is improved when provided with compositions comprising an extracted mineral element composition. | 01-21-2016 |
| 20160015747 | ANTI-GLYCATION METHODS AND COMPOSITIONS - The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation related conditions including diabetes, atherosclerosis, arthritis, mental conditions and vision impairment. | 01-21-2016 |
| 20160038540 | AN ANTICOAGULATION FLUID COMPRISING CITRATE AND PHOSPHATE - The present invention concerns an anticoagulation fluid comprising 10-40 m M citrate and 0.1-4 m M phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in the dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit. | 02-11-2016 |
| 20160113844 | Compositions And Methods For Bioactive Dental Composites - Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described. | 04-28-2016 |
| 20160175356 | FORMULATIONS OF CALCIUM AND PHOSPHATE FOR ORAL INFLAMMATION | 06-23-2016 |
| 20160175481 | BONE REGENERATION MATERIAL KIT, PASTE-LIKE BONE REGENERATION MATERIAL, BONE REGENERATION MATERIAL, AND BONE BONDING MATERIAL | 06-23-2016 |
| 20160183563 | FEED FOR LACTATING RUMINANTS - A feed for ruminants may include at least one fatty acid component covalently linked with a carrier particle such that ingestion of the feed by lactating ruminants may provide for an increase in the amount of milk produced by the ruminant, and/or an increase in the fat content of the milk produced. | 06-30-2016 |
| 20160193391 | INTRAOCULAR DRUG DELIVERY AND FILTER DEVICE AND METHODS OF USING SAME | 07-07-2016 |
| 20160199404 | Mineral, Nutritional, Cosmetic, Pharmaceutical, And Agricultural Compositions And Methods For Producing The Same | 07-14-2016 |
| 20180022609 | Producing Calcium Phosphate Compositions | 01-25-2018 |
| 20190142862 | DIARRHEA-PREVENTING NUTRITIONAL COMPOSITION | 05-16-2019 |
