| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424549000 | Skeleton (e.g., bone, teeth, etc.) | 66 |
| 20080233203 | POROUS ORTHAPEDIC MATERIALS COATED WITH DEMINERALIZED BONE MATRIX - A biomaterial comprising a porous biocompatible structure and a demineralized bone extract coated onto into the pores of the biocompatible structure are provided. The biomaterial may also comprise a demineralized bone gelatin where the gelatin may be coated over the extract coating or mixed with the extract coating before being applied to the biocompatible structure. Methods for making the biomaterial are also provided. | 09-25-2008 |
| 20080311220 | Method for producing demineralized bone matrix easily releasing bone morphogenetic protein and method for extracting bone morphogenetic protein using demineralized bone matrix by irradiation - Disclosed is a method for producing demineralized bone matrix with improvement of releasing bone morphogenetic protein by irradiating the demineralized bone matrix, the demineralized bone matrix produced by the producing method, a method for extracting bone morphogenetic protein using the demineralized bone matrix, and the bone morphogenetic protein extracted by the extracting method. The demineralized bone matrix produced according to the present invention and the bone morphogenetic protein extracted by using the demineralized bone matrix can be advantageously used in manufacturing bone restorative implants, bone growth accelerating compositions, and/or health aids or supplementary food products. | 12-18-2008 |
| 20090047360 | Bone morphogenic protein binding peptide - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 02-19-2009 |
| 20090155378 | OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE - An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents. | 06-18-2009 |
| 20090304807 | METHOD FOR PREPARING A PRION-FREE BOND GRAFTING SUBSTITUTE - The present invention relates to a method for preparing a bone graft substitute using bovine bone, and more particularly to a method for preparing a safe bone graft substitute which does not have the risk of infection with bovine spongiform encephalopathy, the method comprising treating bovine bone with sodium hypochlorite and treating the treated bone at a high temperature of more than 600° C. The bone graft substitute does not cause an immune response, because it is prepared by effectively removing lipids and organic substances from bovine bone having a structure very similar to that of the human bone. Also, it has excellent osteoconductivity, and is free of prion, and thus it does not have the risk of infection with bovine spongiform encephalopathy. According to the disclosed invention, the bone graft substitute having such advantages can be prepared in a simple manner. | 12-10-2009 |
| 20100112083 | PHARMACEUTICAL PRODUCT FOR MODULATING BONE FORMATION, PROCESS FOR MODULATING BONE FORMATION - A pharmaceutical product and a process for bone regeneration and neoformation, which uses sirtuin modulators such as resveratrol and/or trans-resveratrol resulting in the substantial acceleration in the process of integration of biomaterials to the body, substantially shortening the recovery period of the injured or lost organ. | 05-06-2010 |
| 20100166879 | CANCELLOUS BONE GRAFT SUBSTITUTE AND METHOD OF MANUFACTURING THE SAME - A cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute are provided, and more particularly, a cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute by which defatting, demineralizing, cleaning, and sterilizing processes are performed within a short time using a supersonic cabitation without damaging a surface and an inside of a bone tissue so as to further rapidly, effectively supply an allogeneic or xenogeneic bone graft substitute. Internal and external concentrations of Ca++ of the allogeneic or xenogeneic bone graft substitute are effectively removed so as to maintain physical properties of the allogenetic or xenogeneic bone graft substitute. | 07-01-2010 |
| 20100196499 | Xenograft Bone Matrix for Orthopedic Applications - The invention provides for the use of an improved xenograft bone particulate with respect to osteo-integration and bone remodeling, while diminishing the primate-to-pig immunological response using established bone-processing technique. Work was carried out using undecalcified bone to determine immunocompatibilty and bone remodeling potential of processed porcine bone struts following onlay graft implantation. New bone formation was evident, including the infiltration of cellular materials responsible for fusion and bone reconstruction. | 08-05-2010 |
| 20100203155 | SEGMENTED DELIVERY SYSTEM - A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses. | 08-12-2010 |
| 20100247672 | POLYURETHANE/BONE COMPOSITIONS AND METHODS - A flowable, injectable composite that comprises mineralized allograft bone; and at least one degradable polyurethane that has a quasi-prepolymer and a resin mix, the resin mix having a polyester polyol and a catalyst; wherein the composite has a compression strength of greater than about 10 MPa and a modulus of greater than about 1 GPa. | 09-30-2010 |
| 20100255115 | BONE FILLER MATERIAL - Described are bone generation matrixes having an admixture of demineralized bone matrix (DBM) particles and/or bone chips in combination with at least one binding agent selected from the group consisting of alginate, lectin, pectin, gellan gum, starch, collagen and combinations thereof in an aqueous solvent, wherein the DBM particles and/or bone chips are present in an amount of at least 65% by dry weight and the ratio of the aqueous solvent to the dry weight of the DBM particles/bone chips and at least one binding agent is between about 1:1 to about 1:6. | 10-07-2010 |
| 20110038946 | RELEASE OF ANTIBIOTIC FROM INJECTABLE, BIODEGRADABLE POLYURETHANE SCAFFOLDS FOR ENHANCED BONE FRACTURE HEALING - A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form. | 02-17-2011 |
| 20110052718 | Synergistic Phytoceutical Compositions - Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects. | 03-03-2011 |
| 20110070312 | BONE MATRIX COMPOSITIONS AND METHODS - Methods for demineralizing bone are provided. In some embodiments, the methods include demineralizing the bone in a demineralization medium and separating the bone into particles during demineralization. In other embodiments, the methods include placing the bone in a demineralization medium and treating the demineralization medium while the bone is in the demineralization medium to optimize the demineralization process. | 03-24-2011 |
| 20110104299 | BONE GRAFT MATERIALS DERIVED FROM MINERALIZED GELATIN - The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that include such mineralized gelatin carriers including DBM bone products; and kits that include mineralized gelatin carriers formed from bone. The present invention further provides methods for making DBM bone products, wherein both the DBM and a mineralized gelatin carrier for the DBM are derived independently from a bone lot. | 05-05-2011 |
| 20110111050 | Herbal medicinal composition and herbal medicinal extract for inducing production of peripheral blood stem cells and method for preparing the same - A herbal medicinal composition and a herbal medicinal extract for inducing production of peripheral blood stem cells and a method for preparing the same. The herbal medicinal composition contains herbal medicinal herbs disclosed herein such as Cinnamomum Ramulus, Paeoniae (Ovatae) Radix Rubra, Glycyrrhizae Radix, Zingiberis Rhizoma, Jujubae Fructus, Anelicae Radix, and Astragali Radix. | 05-12-2011 |
| 20110183000 | ARTIFICIAL BONE MATERIAL HAVING CONTROLLED CALCIUM ION ELUTION - Disclosed is an artificial bone material having controlled calcium ion elution, which does not induce cytotoxicity or any inflammatory response. It is found that the elution of a calcium ion from an artificial bone material for transplantation which contains a calcium-containing substance can be prevented effectively by subjecting the carrier to a surface treatment or adding a surface-treating agent to the carrier. It is also found that the induction of cytotoxicity can be prevented and the induction of an inflammatory response can also be prevented by using the above-mentioned carrier having controlled calcium ion elution. | 07-28-2011 |
| 20110236501 | INJECTABLE DUAL DELIVERY ALLOGRAPH BONE/POLYMER COMPOSITE FOR TREATMENT OF OPEN FRACTURES - A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form. | 09-29-2011 |
| 20110262554 | COMPOSITIONS FOR REPAIR OF DEFECTS IN OSSEOUS TISSUES, AND METHOS OF MAKING THE SAME - Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. | 10-27-2011 |
| 20120076868 | CROSS-LINKED BIOACTIVE HYDROGEL MATRICES - The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking. | 03-29-2012 |
| 20120100225 | OSTEOINDUCTIVE BONE GRAFT INJECTABLE CEMENT - Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption. | 04-26-2012 |
| 20120148681 | Peptides and peptide compositions having osteoinductive activity - Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold compositions containing at least one peptide or combinations of peptides are therapeutic agents for stimulating and promoting osteogenic activity and osteoinduction activity for cells. The scaffold is for example apatite, natural cancellous bone, demineralized natural cancellous bone, collagen, calcium phosphate, or hydroxyapatite. | 06-14-2012 |
| 20120195971 | Method for Preparing Mechanically Macerated Demineralized Bone Materials and Compositions Comprising the same - The present invention relates generally to methods for preparing mechanically macerated demineralized bone materials that are useful in, or as, implants having a variety of orthopedic applications. More particularly, the demineralized bone materials prepared according to the present invention comprise web-like sections that are compression- and extrusion-resistant and thus, suitable for use in, or as, bone implants or bone grafting materials. Additionally, the web-like morphology increases the surface area of the graft and thereby facilitates the rehydration of the graft, should it be freeze dried. The increased surface area also allows for increased contact with autologous growth factors. The present invention further relates to the demineralized bone materials prepared by the disclosed methods and compositions comprising the same. Methods for preparing a bone void for orthopedic applications, such as bone implants, using the demineralized bone materials or compositions thus prepared are also provided. | 08-02-2012 |
| 20120207847 | Cartilage Repair - This invention relates to compositions, methods of preparation thereof, and use thereof for cartilage repair. | 08-16-2012 |
| 20120213859 | PROCESS FOR DEMINERALIZATION OF BONE MATRIX WITH PRESERVATION OF NATURAL GROWTH FACTORS - A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process. | 08-23-2012 |
| 20120258178 | DEMINERALIZED BONE MATRIX COMPOSITIONS AND METHODS - Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed. | 10-11-2012 |
| 20120308665 | MATERIAL FOR OSTEOPLASTY AND TISSUE ENGINEERING - A biomaterial for osteoplasty has a preserved native spatial organization of collagen matrix and mineral component of bone fabrics of natural origin, for example, containing 25% collagen and 75% mineral substances. The biomaterial is demineralized (compared to original concentration) to contain from 0 to 95% of the original mineral concentration, preferably from 5 to 80%, more preferably from 10 to 60%. The proteins are composed of 99% of collagen and 1% of other proteins. The biomaterial contains bone sulfated glycosaminoglycans (sGAG), whose concentration varies from 0.3 to 3 mg per 1 cm | 12-06-2012 |
| 20130004583 | CELL HOMOGENATE FROM STEM CELLS DERIVED FROM GROWING DEER ANTLERS, A METHOD OF OBTAINING IT AND ITS USE - The subject of the present invention is a bioactive cell homogenate produced from cells belonging to the MIC-1 stem cell line derived from growing deer antlers (Cervidae) deposited at the DSMZ under the accession DSM ACC2854, a method of producing and using it. The present invention also encompasses a pharmaceutical or cosmetic composition containing the above-mentioned homogenate. | 01-03-2013 |
| 20130071486 | ACELLULAR TISSUE MATRICES MADE FROM ALPHA-1,3-GALACTOSE-DEFICIENT TISSUE - The invention provides acellular tissue matrices made from collagen-containing tissues of animals genetically modified so as to be deficient in the galactose 1,3-galactose epitope and methods of making and using such acellular tissue matrices. | 03-21-2013 |
| 20130101675 | Cross-Linked Non-Demineralized Collagenous Biomaterial - A cross-linked non-demineralized collagenous biomaterial and a method for making and using the same to regenerate tissue are described. The collagenous biomaterial is produced by sourcing a raw material of bone powder and tendon which were not subjected to treatment that would demineralize them, extracting the raw material to form a collagenous biomaterial, and irradiating the collagenous biomaterial with gamma radiation. The collagenous biomaterial is administered to a treatment site by an administration apparatus. | 04-25-2013 |
| 20130189371 | CROSS-LINKED BIOACTIVE HYDROGEL MATRICES - The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking. | 07-25-2013 |
| 20130316012 | Method of Demineralizing Bone - The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity. | 11-28-2013 |
| 20140017333 | METHOD FOR FERMENTING ANTLERS, VENISON, OR DEER BONES USING MUSHROOMS, AND RESULTANT FERMENTED PRODUCTS - The present invention relates to a method of fermenting velvet antler (or venison or deer bone) together with a mushroom concentration in order to increase the efficacy thereof, and a fermentation product obtained thereby. In accordance with the present invention, velvet antler is fermented in a state in which it was not concentrated or ground, and the shape thereof is maintained after fermentation. Thus, the loss of velvet antler is insignificant, and the fermented velvet antler has a high efficacy and can be used in various shapes in subsequent processes. | 01-16-2014 |
| 20140044799 | MOLECULAR SIGNATURE OF CUTANEOUS PIGMENTARY SPOTS, ASSOCIATED WITH THE ORGANIZATION OF THE EXTRACELLULAR MATRIX - The present invention concerns a molecular signature of cutaneous pigmentary spots, comprising the genes MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2, and various applications of this signature. In particular, the invention concerns a method for characterizing a known or suspected pigmentary spot in a human being, comprising comparing the levels of expression in skin samples obtained from said spot and from adjacent undamaged skin, of at least one dermal gene linked to matrix remodelling or to its extracellular proteoglycan and glycoprotein components, selected from the list constituted by the genes MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2. The invention also concerns methods for evaluating the efficacy of a pigmentary spot treatment, cosmetic and therapeutic methods for the treatment of pigmentary spots, and various modulators for said genes, and their use. | 02-13-2014 |
| 20140065239 | OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE - An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents. | 03-06-2014 |
| 20140170232 | PROCESS FOR DEMINERALIZATION OF BONE MATRIX WITH PRESERVATION OF NATURAL GROWTH FACTORS - A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process. | 06-19-2014 |
| 20140186459 | COMPOSITIONS AND METHODS FOR FORMING AND STRENGTHENING BONE - Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones. | 07-03-2014 |
| 20140199409 | OXYGENATED DEMINERALIZED BONE MATRIX FOR BONE GROWTH - An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation. | 07-17-2014 |
| 20140205674 | METHOD OF PREPARING BONE MATERIAL HAVING ENHANCED OSTEOINDUCTIVITY - Methods for increasing osteoinductivity and/or surface area of bone material are provided. The methods include providing bone material and dehydrating the bone material with a solvent at its critical point. A useful solvent for critical point dehydrating is carbon dioxide. Critical point dehydration resulting in increased osteoinductivity and/or surface area can be applied to many types of bone material including bone particles, bone chips, bone fibers, bone matrices, both demineralized and non-demineralized. An implantable composition having an enhanced osteoinductivity and/or osteoconductivity is also provided. The implantable composition contains demineralized bone matrix dried at critical point of carbon dioxide. Critical point dried fibers of a demineralized bone matrix have a BET value from about 40 m | 07-24-2014 |
| 20140255506 | OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE - An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents. | 09-11-2014 |
| 20140335197 | COMBUSTION SYNTHESIS OF CALCIUM PHOSPHATE CONSTRUCTS AND POWDERS DOPED WITH ATOMS, MOLECULES, IONS, OR COMPOUNDS - The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material. | 11-13-2014 |
| 20140342013 | CALCIUM PHOSPHATE CEMENT COMPOSITIONS THAT SET INTO HIGH STRENGTH POROUS STRUCTURES - Calcium phosphate cement compositions are provided. Aspects of the cement compositions include a dry reactant component comprising a reactive α-tricalcium phosphate component, a multi-size pore forming calcium sulphate dihydrate component and a demineralized bone matrix component. During use, the dry reactant is combined with a setting fluid to produce a sellable composition that sets into a high strength porous product. Aspects of the invention further include the settable compositions themselves as well as kits for preparing the same. Methods and compositions as described herein find use in a variety of applications, including hard tissue repair applications. | 11-20-2014 |
| 20150037432 | SELF-ASSEMBLY OF COLLAGEN FIBERS FROM DERMIS, FASCIA AND TENDON FOR TISSUE AUGMENTATION AND COVERAGE OF WOUNDS AND BURNS - The present invention is a composition of a self-assembly of collagen fibers made from a plurality of sized pieces of a source material. The source material made from animal or human tissue selected from one of dermis, tendon, fascia or dura mater. The self-assembly occurring by induction of a magnetic field in a liquid medium. | 02-05-2015 |
| 20150050358 | IMPLANT SUPPORT COMPOSITION AND METHODS OF USE - This disclosure describes an implant support composition and methods of using the implant support composition. Generally, the implant support composition includes a filler, an osteoconductive material, an osteoinductive material, and an antimicrobial agent. | 02-19-2015 |
| 20150110890 | BONE MARROW ASPIRATE ENHANCED BONE GRAFT - A method of preparing a bone graft. Mixing bone marrow aspirate with an effective amount of a binding reagent that is capable of binding with red blood cells in the bone marrow aspirate. The bound red blood cells are aggregated. The aggregated bound red blood cells are separated from the bone marrow aspirate to provide a supernatant. At least a portion of the supernatant is associated with an osteoconductive matrix to form the bone graft. | 04-23-2015 |
| 20150110891 | Cell Homogenate From Stem Cells Derived From Growing Deer Antlers, A Method Of Obtaining It And Its Use - The subject of the present invention is a bioactive cell homogenate produced from cells belonging to the MIC-1 stem cell line derived from growing deer antlers (Cervidae) deposited at the DSMZ under the accession DSM ACC2854, a method of producing and using it. The present invention also encompasses a pharmaceutical or cosmetic composition containing the above-mentioned homogenate. | 04-23-2015 |
| 20150140115 | ORIENTAL MEDICINE COMPOSITIONS MARKED AS SEC 22 AND SEC 33 FOR IMPROVING CHILDREN'S UNDERWEIGHT, LOW GROWTH AND DEPRESSED RESPIRATORY ORGAN - The present invention relates to oriental medicine compositions marked as SEC 22 and SEC 33 for improving digestive functions and respiratory functions for improving children's underweight, low growth and depressed respiratory organ, an oriental medicine derived therefrom, and methods of preparing them. According to an example of the present invention, the oriental medicine composition containing broiled fruit of | 05-21-2015 |
| 20150140116 | BONE IMPLANT MATERIALS COMPRISING CROSS-LINKED BIOACTIVE HYDROGEL MATRICES - The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking. | 05-21-2015 |
| 20150147408 | METHOD VALIDATION UNIT - A Method Validation Unit (MVU) for the evaluation of the level of sterilisation in a sterilisation method involving the use of a fluid at or near the supercritical pressure and temperature for that fluid, wherein the MVU comprises a sterilisation indicator housed within a gas-permeable container, wherein the sterilisation indicator comprises an indicator medium and a population of one or more colony forming units (CFUs), and wherein the indicator medium comprises one or more structural features representative of the internal structure of a material to be sterilised in the sterilisation method. | 05-28-2015 |
| 20150307940 | MOLECULAR SIGNATURE OF CUTANEOUS PIGMENTARY SPOTS, ASSOCIATED WITH THE EXTRACELLULAR MATRIX - The present invention concerns a molecular signature of cutaneous pigmentary spots, comprising the genes TGFBR2, TGFBI, BMP2, SMAD3, THBS2, TGFBR3, SEMA5A, SMAD7, SOSTDC1, FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMA3, ITGAV, ITGB1 and ACTN1, and various applications of this signature. In particular, the invention concerns a method for characterizing a known or suspected pigmentary spot in a human being, comprising comparing the levels of expression in skin samples obtained from said spot and from adjacent undamaged skin, of at least one dermal gene linked to the extracellular matrix selected from the list constituted by the genes TGFBR2, TGFBI, BMP2, SMAD3, THBS2, TGFBR3, SEMA5A, SMAD7, SOSTDC1, FRAS1, LEPREL1, MATN2, DST, PLOD2, ITGA2, COL6A3, CRTAP, LAMC1, LAMB3, LAMA3, ITGAV, ITGB1 and ACTN1. The invention also concerns methods for evaluating the efficacy of a pigmentary spot treatment, cosmetic and therapeutic methods for the treatment of pigmentary spots, and various modulators for said genes, and their use. | 10-29-2015 |
| 20150314043 | TISSUE PROCESSING APPARATUS AND METHOD - A tissue treatment apparatus and method for treating biologic tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the tissue sample is bone material and the treatment procedure effects demineralization of the bone material | 11-05-2015 |
| 20150335785 | CONSTRUCTS CONTAINING BONE TISSUE AND METHODS FOR MAKING THE SAME - The invention relates to a bone material scaffold or a synthetic bone material and a process for making the same. The bone material may comprise calcium phosphate, and the calcium phosphate may comprise multiple phases. | 11-26-2015 |
| 20150352235 | TISSUE ALLOGRAFT STERILIZATION METHOD - The invention is a novel method of sterilizing bone and soft tissues intended for human transplantation. In one embodiment the process includes steps of subjecting transplants to high hydrostatic pressures of aqueous fluid to which chlorhexidine gluconate or similar sterilizing chemicals have been added. | 12-10-2015 |
| 20150366916 | METHOD FOR PRODUCING A PLURALITY OF TEETH FROM ONE ISOLATED TOOTH GERM - The object of the present invention is to provide a method for manufacturing multiple teeth from one isolated tooth germ in order to increase the absolute number of tooth germs that can be employed for transplantation. | 12-24-2015 |
| 20150366917 | COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE - A composition for preventing or treating inflammatory disease and that is effective for inflammatory disease such as fulminant hepatitis and interstitial pneumonia. For such an objective, the present uses a culture supernatant obtained by culturing dental pulp stem cells as the active ingredient of the composition for preventing or treating inflammatory disease. | 12-24-2015 |
| 20150374880 | Solid Substrates for Mitigating or Preventing Cell and Tissue Adhesion and Vascularization - This invention provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate comprises a marine organism skeletal derivative and is characterized by a specific fluid uptake capacity value of less than 40%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value and processes for selection of an optimized marine organism skeletal derivative-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by having a contact angle value of more than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by a minimal surface roughness (Ra) or substantial surface smoothness, as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same. | 12-31-2015 |
| 20160000833 | METHOD OF PREPARING DEER BONE EXTRACT HAVING INCREASED AMOUNT OF GANGLIOSIDE - Disclosed herein is a method of preparing a deer bone extract in which deer bones are subjected to extraction at normal pressure and extraction under pressure to minimize decomposition of deer bone-derived gangliosides by heat and to increase protein extraction yield. | 01-07-2016 |
| 20160008417 | Plant and Animal Extracts and Related Methods | 01-14-2016 |
| 20160058909 | MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME - Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity. | 03-03-2016 |
| 20160114079 | Composite Grafts, Systems, and Methods - Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided. | 04-28-2016 |
| 20160151537 | Bioactive Grafts and Composites | 06-02-2016 |
| 20160158413 | METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH - The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect. | 06-09-2016 |
| 20160166303 | BONE GRAFT MATERIALS, DEVICES AND METHODS OF USE | 06-16-2016 |
| 20160166729 | IMPLANTABLE COMPOSITIONS AND METHODS FOR PREPARING THE SAME | 06-16-2016 |
| 20160184477 | Solid Substrates for Promoting Cell and Tissue Growth - This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrate for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This inventions also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and application of the same. | 06-30-2016 |
| 20190144435 | DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS | 05-16-2019 |
