Class / Patent application number | Description | Number of patent applications / Date published |
424283100 | Lipid or oil | 24 |
20100172941 | Adjuvant Compositions and Methods of Use - This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions. | 07-08-2010 |
20100278875 | PROSTAGLANDIN E2 (PGE2) AS AN ADJUVANT IN MONOCLONAL ANTIBODY GENERATION - The present invention provides PGE2 as a novel adjuvant for enhancing the immune response in a host, as well as methods of using PGE2 to enhance B cell response and thereby increasing antibody titer against a given immunogen are also disclosed and antibodies produced by at least one method of the present invention. | 11-04-2010 |
20120009222 | MODULATION OF THE IMMUNE RESPONSE - The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same. | 01-12-2012 |
20120027803 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 02-02-2012 |
20120058149 | TREATMENT OF INFECTION - The invention relates to compositions including a substance useful as an adjuvant for potentiating an immune response, and methods of using the composition in individuals with infections of tissue within or adjacent to a transformation zone, such as the transformation zone of the cervix or anal canal. | 03-08-2012 |
20120093875 | AMINOCYCLITOL COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES - Aminocyclitol compounds and uses thereof as pharmaceutical compositions for the treatment of diseases associated with alterations in iNKT cells, more specifically autoimmune diseases, cancer, infections caused by pathogenic microorganisms or inflammatory diseases. Furthermore, the invention relates to the process for obtaining said compounds. | 04-19-2012 |
20120141542 | METHOD OF USING PUNICIC ACID TO ENHANCE IMMUNE RESPONSE AND PREVENT METABOLIC DISORDERS - Disclosed is a method of enhancing the immune response of an animal, including mammals and humans, to prevent or ameliorate immunoinflammatory diseases such as Inflammatory Bowel Disease, increase immune system development, maintain or increase CD4 | 06-07-2012 |
20120156249 | GENETICALLY MODIFIED ORGANISM FOR THE PRODUCTION OF LIPIDS - The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism. | 06-21-2012 |
20120164181 | Non-Specific Immunostimulating Agents - The present invention includes a lipid vesicle. The invention further relates to a method of treating and/or preventing a disease or disorder involving administering such a lipid vesicle to an animal in need thereof. | 06-28-2012 |
20120195931 | POLYCHLORINATED BIPHENYLS AND SQUALENE-CONTAINING ADJUVANTS - When using squalene in a vaccine adjuvant, there is a possibility of contamination with polychlorinated biphenyls (PCBs). Environmental exposure to PCBs may adversely affect children's immune responses to routine vaccinations. Thus the invention uses squalene with low or no PCB contamination, particularly when derived from shark liver. | 08-02-2012 |
20120321669 | ANTIGENIC COMPOSITIONS - The invention relates to antigenic compositions and to methods for immunizing animals using same. The antigenic compositions comprise a lipid formulation most usually in solid form, and at least one antigenic component. A preferred antigenic component is a living organism. In a preferred embodiment the composition is formulated for oral administration. | 12-20-2012 |
20130084309 | PROCESS FOR THE PREPARATION OF O/W EMULSION - The present invention provides a process for the production of an oil in water emulsion comprising the steps of: a) dissolving a surfactant in a volume of water or aqueous solution to produce a surfactant solution; and b) diluting the surfactant solution in a volume of water or aqueous solution greater than the volume of the surfactant solution to produce an aqueous phase. | 04-04-2013 |
20130089573 | NOVEL PROCESS - The present invention provides processes for the production of a submicron oil in water emulsion comprising the steps of preparing a submicron oil in water emulsion; pre-filtering the oil in water emulsion through a first sterile grade filter and again filtering the oil in water emulsion through a second sterile grade filter. | 04-11-2013 |
20130195920 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 08-01-2013 |
20130251753 | TREATMENT OF INFECTION - The invention relates to compositions including a substance useful as an adjuvant for potentiating an immune response, and methods of using the composition in individuals with infections of tissue within or adjacent to a transformation zone, such as the transformation zone of the cervix or anal canal. | 09-26-2013 |
20140134210 | COMPOSITION CONTAINING ANTIBIOTICS AND LYSOPHOSPHATIDYLCHOLINE FOR BOOSTING IMMUNITY OR TREATMENT OF BACTERIAL INFECTIONS - The present invention relates to: a pharmaceutical composition containing lysophosphatidylcholine or analogs thereof and antibiotics as active ingredients for boosting immunity or the treatment of bacterial infections; a method for boosting immunity or the treatment of bacterial infections, which comprises a step for administering the composition; and a kit containing the composition for boosting immunity or the treatment of bacterial infections. | 05-15-2014 |
20140186406 | Treatment of Infection - The invention relates to compositions including a substance useful as an adjuvant for potentiating an immune response, and methods of using the composition in individuals with infections of tissue within or adjacent to a transformation zone, such as the transformation zone of the cervix or anal canal. | 07-03-2014 |
20150024009 | GENETICALLY MODIFIED ORGANISM FOR THE PRODUCTION OF LIPIDS - The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism. | 01-22-2015 |
20150030638 | Ingenol Derivatives in the Reactivation of Latent HIV - The present invention broadly relates to the use of certain ingenol derivatives as HIV reactivators of latent HIV virus in viral reservoirs. In another aspect, the present invention relates to an association comprising such ingenol derivatives and antiretroviral agents substantially active against actively replicating virus. | 01-29-2015 |
20160009637 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS | 01-14-2016 |
20160038454 | INTRAVENOUS FORMULATIONS OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICANCER AGENTS - Intravenous formulations of triptolide and triptolide derivatives are disclosed for use in immunomodulation and anti-proliferative agents. | 02-11-2016 |
20160193328 | Immunoadjuvant Compositions and uses Thereof | 07-07-2016 |
20160199339 | COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING ASTHMA | 07-14-2016 |
20160199486 | ARRANGING INTERACTION AND BACK PRESSURE CHAMBERS FOR MICROFLUIDIZATION | 07-14-2016 |