| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424247100 | Clostridium (e.g., Clostridium tetani, Clostridium difficile, Clostridium perfringens, Clostridium botulinum, Clostridium chauvoei, etc.) | 19 |
| 20100062025 | Use of Clostridium perfringens type C bacterium for the manufacture of a vaccine - The present invention relates to the use of a vaccine comprising | 03-11-2010 |
| 20100119554 | TRANSPLANTS - The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. | 05-13-2010 |
| 20100166800 | RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE - The present invention discloses attenuated | 07-01-2010 |
| 20100196423 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases - The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. | 08-05-2010 |
| 20100330125 | NOVEL POLYSACCHARIDE IMMUNOGENS FROM CLOSTRIDIUM DIFFICILE - The application relates to | 12-30-2010 |
| 20110268765 | Injectable Botulinum Toxin Formulations - This invention provides novel injectable compositions comprising botulinum toxin that may be administered to a subject for various therapeutic, aesthetic and/or cosmetic purposes. The injectable compositions contemplated by the invention exhibit one or more advantages over conventional botulinum toxin formulations, including reduced antigenicity, a reduced tendency to undergo unwanted localized diffusion following injection, increased duration of clinical efficacy or enhanced potency relative, faster onset of clinical efficacy, and/or improved stability. | 11-03-2011 |
| 20110311589 | COMPOSITIONS AND DOSAGE REGIMES COMPRISING A CLOSTRIDIAL VACCINE AND LEVAMISOLE - A composition and dosage regime including a vaccine and levamisole for the treatment of clostridial diseases and helminthiasis. New methods of administration relating to particular dosage regimes of such a composition are also claimed. | 12-22-2011 |
| 20120014993 | CLOSTRIDIUM TAENIOSPORUM SPORES AND SPORE APPENDAGES AS SURFACE DISPLAY HOSTS, DRUG DELIVERY DEVICES, AND NANOBIOTECHNOLOGICAL STRUCTURES - The present disclosure relates to spore surface display compositions comprising a spore having at least one nucleic acid sequence encoding for at least one polypeptide and operable to express the polypeptide on a surface of the spore. In some embodiments, the displayed polypeptide is displayed with a spore carrier protein. In some embodiments, the spore may be derived from a | 01-19-2012 |
| 20130129783 | USE OF BOTULINUM NEUROTOXIN TO ALLEVIATE VARIOUS DISORDERS - Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration of a botulinum toxin. | 05-23-2013 |
| 20130149339 | COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS - It was found that bacteria belonging to the genus | 06-13-2013 |
| 20130315959 | COMPOUNDS - The invention provides a synthetic | 11-28-2013 |
| 20140271718 | NOVEL TYPE 1 DIABETES VACCINES, AND METHODS OF USE - The subject invention provides compositions for alleviating type 1 diabetes (T1D). In preferred embodiments, the compositions comprise an effective amount of one or more antigen presenting cells (APCs) that have been pulsed with one or more bacterial isolates and/or compounds from the isolates. The bacteria used to pulse the APCs are, preferably, those that confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. In specific embodiments, these bacteria may be, for example, | 09-18-2014 |
| 20140302094 | VACCINE - There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by | 10-09-2014 |
| 20140314813 | CLOSTRIDIUM DIFFICILE LIPOTEICHOIC ACID AND USES THEREOF - A novel lipoteichoic acid (LTA) was isolated from | 10-23-2014 |
| 20150322176 | NOVEL POLYSACCHARIDE IMMUNOGENS FROM CLOSTRIDIUM BOLTEAE ISOLATED FROM AUTISTIC SUBJECTS AND METHODS AND USES THEREOF - The disclosure relates to | 11-12-2015 |
| 20160030542 | Toxoid, Compositions and Related Methods - Methods of producing purified clostridial toxin comprising tangential flow filtration, hydrophobic interaction chromatography and anion exchange chromatography are disclosed. These methods provide good yields of | 02-04-2016 |
| 20160120968 | Compositions and Methods for Immunizing Against C. Difficile - This disclosure relates to methods for eliciting an immune response against | 05-05-2016 |
| 20160143960 | COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS - It was found that bacteria belonging to the genus | 05-26-2016 |
| 20160166672 | Atoxic recombinant holotoxins of Clostridium difficile as immunogens | 06-16-2016 |
