| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424780060 | Skin burn or open wound treatment | 58 |
| 20080299067 | Functionalised Siloxanes for Scar Tissue Treatment - A novel composition for use in treating a wound, burn or other skin condition comprises one or more compounds of formula (I), wherein: m = 0-6, n = 6-100, Q, R and R′ may be independently selected from, C1-5 alkyl, OU, UOCH2CH3, CH2CH3, UOCH3, OH, O(CH2)y(OU)yCH3, (OCH2CH2)yOU, (OCH2CH2)yOH, UOH, UOU′, UCO2U′, CO2U, UCO2COU, CO2H, UCO2H, COX, UCOX, UCO2 R′, CO2COU, Aryl, ArylU, ArylUU, ArylUU′U″, NH2, UNH2, NHU, NUU′, NO2, UNO2, UCONH2, CONH2, UCONHU′, CONHU, UCONU′U″, CONU′U″, halogen, PO4H3, PO4H3-z, PO4H3-zU (z = 0, 1, 2 or 3), PU3, P U′U″U′″SH, SO2 and SO3H; wherein U, U′, U″ and U′″ may be independently selected from any alkyl, alkenyl or alkynyl group where the number of carbon atoms is between 1 and 31; wherein X=halogen; wherein y=1-100; provided that Q, R and R′ can not all be C1 alkyl; and wherein the compound of formula (I) is present in an amount of at least 1% of the composition. | 12-04-2008 |
| 20090191145 | ADHESIVE SYSTEMS CONTAINING POLYISOCYANATE PREPOLYMERS AND ASPARTATE-ESTER CURING AGENTS, PROCESSES FOR PREPARING THE SAME, MEDICAL USES THEREFOR AND DISPENSING SYSTEMS FOR THE SAME - Adhesive systems comprising: (A) an isocyanate group-containing prepolymer prepared by reacting: (A1) an aliphatic isocyante; and (A2) a polyol having a number average molecular weight of ≧400 g/mol and 2 to 6 OH groups; and (B) a curing component comprising: (B1) an amino group-containing aspartate ester of the general formula (I); | 07-30-2009 |
| 20090246164 | TISSUE ADHESION - A method of adhering biological tissue that includes applying a bio-degradable adhesive to the tissue. The adhesive includes a moisture-curable, isocyanate-functional component prepared by reacting (a) a multi-functional isocyanate component and (b) a multi-functional active hydrogen component that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100. The ratio R of active hydrogen groups to isocyanate groups can be less than 1.0. | 10-01-2009 |
| 20090297469 | Cyanoacrylate Monomer Formulation Containing Diiodomethyl-p-tolylsulfone and 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether - A polymerizable antimicrobial formulation for forming a wound closure adhesive comprising cyanoacrylate monomer, diiodomethyl-p-tolylsulfone and a halogenated hydroxyl diphenyl ether; and a method for closing the approximated edges of a wound with a polymeric film that substantially inhibits the growth of microorganisms, where the polymeric film is formed by use of the polymerizable antimicrobial formulation. | 12-03-2009 |
| 20090317353 | Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator - The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field. | 12-24-2009 |
| 20090317354 | Composition for restoring damaged skin comprising a saccaride and povidone-iodine - The present invention relates to a composition for repairing injured skin containing a saccharide and povidone-iodine. The present invention has the following characteristics: suppresses time-dependent increase of consistency, it is easy to use, it is a soft preparation, and has superior applicability to a deep wounded lesion and a granulation tissue. The composition of the present invention contains 50 to 90% by weight of saccharide, 0.5 to 10% by weight of povidone-iodine, 0.1 to 20% by weight of water and 0.01 to 10% by weight of phospholipid. | 12-24-2009 |
| 20100021414 | Bioabsorbable Adhesive Compounds And Compositions - Bioabsorbable compounds which include a polyalkylene oxide backbone with two or more isocyanate substituents are useful as one component adhesives. Absorbable compositions useful as a two component adhesive contain a) a polyethylene oxide having two or more amine substituents with b) a bioabsorbable diisocyanate compound, or alternatively contain a) a polyethylene oxide having two or more isocyanate substituents with b) a bioabsorbable diamine compound, or, alternatively contain a) a bioabsorbable diisocyanate compound and b) a bioabsorbable diamine compound. | 01-28-2010 |
| 20100034768 | COMPOSITION AND METHOD FOR TREATMENT OF INSECT BITES - A composition for treating wounds of the skin, such as those caused by the bites of small insects or jellyfish, includes a wax or resin, an emulsifier, and ammonium hydroxide. The composition is applied to the skin in a thin layer, and when it dries, it forms a thin, protective film over the wound. Application of the composition has been found to provide temporary and immediate relief of pain and/or itching. The protective film shields the wound, and therefore aids in healing. The composition can be made of any of a variety of waxes or resins, and the emulsion can be formed with long-chain alcohol or fatty acid soaps, such as oleic acid or triethanolamine. | 02-11-2010 |
| 20100158849 | ISOCYANATE TERMINATED MACROMER AND FORMULATION THEREOF FOR USE AS AN INTERNAL ADHESIVE OR SEALANT - A novel macromer or mixture thereof is described herein, comprising isocyanatophenyl ether terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the ether group of the isocyanatophenyl ether terminal isocyanate moieties, thereby forming at least two ether linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein. | 06-24-2010 |
| 20100172860 | WOUND REPAIR COMPOSITION AND METHOD - The invention provides a dressing composition comprising a bisphosphonate matrix metalloproteinase (MMP) inhibitor covalently bound to a polymer wherein, when the dressing is contacted with a wound, substantially all of the bisphosphonate remains with the dressing composition and is unable to enter the wound tissue. The invention also provides for a method of treatment of a wound by contacting a dressing composition comprising a covalently bound MMP inhibitor with the wound fluid to thereby selectively inhibit one or more MMP's in the wound fluid without inhibiting those in the wound tissue. | 07-08-2010 |
| 20100209380 | ADHESIVE FORMULATIONS - The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a polymeric polyol core, which may be treated with a nitroaryl compound to form a nitro ester. The resulting nitro ester groups may be reduced to form amino groups which, in turn, may be treated to form isocyanate groups. The resulting isocyanate may then be reacted with a second component to form adhesive and/or sealant compositions. | 08-19-2010 |
| 20100226873 | Hemostatic Composition with Magnetite - A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound. | 09-09-2010 |
| 20100260702 | BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES - Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: | 10-14-2010 |
| 20110020264 | Method and Composition for the Treatment of Scars - A method and composition for treating healed wounds including hypertrophic scars so as to prevent scarring or reduce the size and improve the appearance of scars comprises applying to the healed wound or scar a composition comprising a fluid, film-forming carrier which may contain one or more active topical ingredients, the carrier hardening to a solid, tangible, membrane juxtaposed to the skin. Novel compositions using the film-forming carrier are also useful to treat a variety of adverse skin disorders, and internal physiological conditions. | 01-27-2011 |
| 20110027216 | PROTEIN-BASED POLYMER TISSUE ADHESIVES FOR MEDICAL USE - Tissue adhesives formed by crosslinking albumin and/or gelatin with certain polyamines and/or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described. | 02-03-2011 |
| 20110117047 | CYANOACRYLATE TISSUE ADHESIVES WITH DESIRABLE PERMEABILITY AND TENSILE STRENGTH - A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m | 05-19-2011 |
| 20110123476 | Adhesive Formulations - The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a multifunctional amine or multifunctional polyol core, with isocyanate and/or polyalkylene oxide arms, which may optionally be capped with electrophilic or nucleophilic groups. These biocompatible components may, in embodiments, be combined with optional cross linkers to form adhesive and/or sealant compositions. | 05-26-2011 |
| 20120039838 | WOUND HEALING COMPOSITIONS BASED ON CYANOACRYLATES AND 5,5-DISUBSTITUTEDHYDANTOINS, INCLUDING PHENYTOIN - A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenyloin; and a method for making said composition. | 02-16-2012 |
| 20120114591 | TREATMENT OF CHRONIC ULCEROUS SKIN LESIONS - The invention provides a method of treating a wound (for example, a chronic ulcerous skin lesion) in a human or non-human mammal (particularly a human). The wound is contacted with a topical hydrogel composition comprising a hydrophilic polymer carrying multiple pendant sulphonyl groups, optionally with multiple pendant carboxylic groups, on each polymer molecule. | 05-10-2012 |
| 20120114592 | Hemostatic Foams - Hemostatic foams Abstract The invention is directed to hemostatic foams and to the preparation of such foams. In a first aspect, the present invention provides a biodegradable hemostatic foam comprising a polymer blend of a water-soluble polymer and a phase-separated polyurethane comprising an amorphous segment and a crystalline segment, wherein at least said amorphous segment comprises a hydrophilic segment. | 05-10-2012 |
| 20120128622 | MRSA Bactericidal Topical Gel - The present invention is directed to an enhanced wound healing composition, including a gel containing vancomycin, useful for the prevention of the spread of resistant-type bacteria. Preferably, the drug is one or more antibiotic agents in therapeutically effective concentrations to reduce or eliminate MRSA. The composition is based on a gel composition containing one or more gel forming compounds, such as one or more polymers, preservatives, and/or pH stabilizers and buffers, which not only maintains a moist wound environment to enhance wound healing, but also provides an antibiotic agent which has sustained potency and stability. The composition, when placed in contact with a treatment site, delivers the drug to the site. By incorporating the drug into the gel composition that is formulated to enhance wound healing, the treatment of such disease is possible in a manner which promotes wound healing while reducing or eliminating the MRSA microbe. | 05-24-2012 |
| 20120134951 | Topical Gels and Methods of Using the Same - Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules. | 05-31-2012 |
| 20120148520 | Organic Iodine Complex Durable Barrier With Antimicrobial Preparations - The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection. | 06-14-2012 |
| 20120213727 | THERAPEUTIC USES OF OLIGOMERIC AND POLYMERIC MONOTERPENES - The invention relates to therapeutic methods comprising use of oligomeric and polymeric forms of the monoterpene compounds alloocimene, limonene, alpha-pinene, beta-pinene, geranyl acetate, alpha-phellandrene, gamma-terpinene, 3-carene and 2-carene. More particularly, the invention relates to methods of treating degenerative neurological conditions, and treating skin disorders. | 08-23-2012 |
| 20120269761 | BIODEGRADABLE ELASTOMERS - The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers. | 10-25-2012 |
| 20120276039 | APTAMER-MODIFIED POLYMERIC MATERIALS FOR THE BINDING OF FACTORS IN A WOUND ENVIRONMENT - The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads. | 11-01-2012 |
| 20120294823 | Method for preparing silk sericin-PVA scaffold using genipin as crosslinking agent - A method for preparing a porous-three-dimensional scaffold good for tissue engineering is described. Sericin forms a three-dimensional scaffold with PVA after freeze-drying having glycerin as a plasticizer and genipin as natural crosslinking agent to help making a strong and stable matrix. Adding glycerin into scaffold gives good uniformity and porosity. Smaller pore sizes and better uniformity are obtained as the concentration of genipin in the scaffold increases. Glycerin retains a high moisture content to allow the presence of water molecule in the matrix structure. Adding genipin results in a higher degree of crosslinking within the scaffold. Crosslinking using genipin is most beneficial in preparing scaffold possesses the best biological and physical properties for wound healing. The present invention describes method for preparing crosslinked matrix whose composition can be appropriately tuned to obtain matrix with desirable characteristics for biological applications. | 11-22-2012 |
| 20130052152 | PROTECTIVE WOUND DRESSING DEVICE FOR ORAL AND PHARYNGEAL SPACE - The present invention provides a wound dressing comprising a tessellated water-soluble molding matrix comprised of a polymer selected from the group consisting of polyvinyl alcohol, gelatin, and mixtures thereof and a 1,1-disubstituted ethylene monomer. The present invention further provides methods of using the wound dressing and kits containing the wound dressing. | 02-28-2013 |
| 20130052153 | METHOD OF PREPARING HYDROGEL STRUCTURE - A method of preparing hydrogel structure, wherein the hydrogel structure comprises: (a) a one way penetrating polyurethane film layer, (b) a hydrophobic pressure sensitive adhesive layer, (c) a multi-directional elastic meltblown nonwoven, (d) an interpenetrating polymer network, and (e) a hydrophilic hydrogel; and the method comprises: (i) coating the hydrogel in a form of solution on the meltblown non-woven to form a product | 02-28-2013 |
| 20130121952 | HYDROGEL CO-POLYMER COMPOSITION AND ITS USES, FOR EXAMPLE AS A WOUND DRESSING - The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanol:water partition coefficient Log P value of less than 0, and, the Log P value of the first monomer is greater (more positive) than the second monomer. The difference between the Log P value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same. | 05-16-2013 |
| 20130136715 | WOUND HEALING COMPOSITIONS BASED ON CYANOACRYLATES AND 5,5-DISUBSTITUTEDHYDANTOINS, INCLUDING PHENYTOIN - A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition. | 05-30-2013 |
| 20130251665 | TREATMENT OF CHRONIC ULCEROUS SKIN LESIONS - The invention provides a method of treating a wound (for example, a chronic ulcerous skin lesion) in a human or non-human mammal (particularly a human). The wound is contacted with a topical hydrogel composition comprising a hydrophilic polymer carrying multiple pendant sulphonyl groups, optionally with multiple pendant carboxylic groups, on each polymer molecule. | 09-26-2013 |
| 20130323195 | HYDROGEL FIBRES AND FIBROUS STRUCTURES - A plurality of fibers or one-dimensional, two-dimensional, or three-dimensional fibrous structures are provided, having fibers from a first raw fiber material. The first raw fiber material contains unsubstituted or partially substituted polyvinyl alcohol and/or unsubstituted or partially substituted polyvinyl alcohol copolymer. The fibers can be crosslinked by tempering the fibers or fibrous structures, with the result that the fibers or the fibrous structure are configured to be gel, in particular hydrogel, fibers or fibrous structures and have excellent stability. | 12-05-2013 |
| 20140023610 | SILICONE GEL-BASED COMPOSITIONS FOR WOUND HEALING AND SCAR REDUCTION - This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing. | 01-23-2014 |
| 20140056839 | METHODS FOR SEALING WOUNDS WITH A STERILIZED COMPOSITION OF A CYANOACRYLATE MONOMER AND A POLOXAMER - The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field. | 02-27-2014 |
| 20140065090 | Reactive Oxidative Species Generating Materials and Methods of Use - Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes. | 03-06-2014 |
| 20140065091 | MEDICAL ADHESIVE FOR STEMMING BLEEDING - The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R | 03-06-2014 |
| 20140065092 | Yarns, fibers or filaments, textile article, and medical device obtained from said yarns for skin cicatrization - The subject of the present invention is yarns, fibers or filaments and also a textile article and a medical device obtained from said yarns, for improving skin cicatrization, in particular by activating collagen synthesis at the surface of the injured skin. The yarns, fibers or filaments of the invention comprise a polymeric matrix and inorganic fillers, uniformly dispersed in the polymeric matrix, having properties of absorption and/or of emission in the 2-20 μm far-infrared region. | 03-06-2014 |
| 20140079661 | NOVEL ADHESIVE COMPOSITIONS AND USES THEREOF - It is provided new adhesive compositions comprising three components, compounds of formula (I), (II) and (III), namely, alkyl cyanoacrylates, alkyl carboxyacrylates and acrylates. It is also provided said compositions for use in medicine and veterinary, as bioadhesives. | 03-20-2014 |
| 20140120052 | COMPOSITION AND METHOD FOR ARRESTING BLOOD FLOW AND FOR FORMING A PERSISTENT MICROBIAL BARRIER - A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa. | 05-01-2014 |
| 20140161761 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 06-12-2014 |
| 20140186289 | Cyanoacrylate Tissue Adhesives with Desirable Permeability and Tensile Strength - A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m | 07-03-2014 |
| 20140242023 | Topical Compositions and Methods of Using the Same - The present invention relates generally to topical compositions and methods of using the same. | 08-28-2014 |
| 20140248231 | BIOCOMPATIBLE HYDROGEL TREATMENTS FOR RETINAL DETACHMENT - Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch. | 09-04-2014 |
| 20140271528 | SOLID POLYGLYCOL-BASED BIOCOMPATIBLE PRE-FORMULATION - Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease. | 09-18-2014 |
| 20140341836 | SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS - Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue. | 11-20-2014 |
| 20140341837 | Ferrate and Povidone Iodine (PI) Composition - A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound. | 11-20-2014 |
| 20140341838 | Biocompatible Adhesive Materials and Methods - Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions. | 11-20-2014 |
| 20140348774 | METHOD FOR TREATING WOUNDS AND TISSUE REPAIR - The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection. | 11-27-2014 |
| 20140348775 | WOUND TREATMENT DRUG FOR EXTERNAL USE - [Problems] The objective is to provide a new low-toxic drug for external use for intractable diseases, such as erosion, decubitus, and skin ulcer, that prevents cicatrization and reduces iodine accumulation on wound surfaces with sufficiently promoting healing. | 11-27-2014 |
| 20140369952 | BIODEGRADABLE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF - A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure. | 12-18-2014 |
| 20140377211 | In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers - An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein. | 12-25-2014 |
| 20150064129 | WOUND HEALING COMPOSITION - The invention discloses a composition comprising hyaluronic acid with a high molecular weight and povidone-iodine in low amount that has advantageous efficacy in enhancing wound healing and maintains high stability. Also disclosed is a method of using the composition of the invention in healing wounds. | 03-05-2015 |
| 20150071869 | WOUND HEALING COMPOSITIONS INCLUDING CYANOACRYLATE MONOMERS AND PHENYTOIN - A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition. | 03-12-2015 |
| 20150139933 | METHOD FOR PREPARATION OF POLY(ALPHA-LIPOIC ACID) POLYMERS - A method for the polymerization of α-lipoic acid and α-lipoic acid derivatives includes preparing an α-lipoic formulation, exposing the α-lipoic formulation to an aqueous phase and a gaseous phase at a gas/water interface, and allowing the α-lipoic formulation to polymerize at the gas/water interface to form a poly(α-lipoic acid) polymer. The α-lipoic formulation can be an α-lipoic solution of an α-lipoic solute and an organic solvent miscible with water, and can also be an α-lipoic acid or oligomer or polymer thereof in liquid (typically melt) form. | 05-21-2015 |
| 20150328357 | WOUND PROTECTING POLYMERS - A wound protecting composition includes an end-functionalized arborescent polymer having at least two branching points to provide at least four ends to the arborescent polymer, the arborescent polymer comprising polyisobutylene; and an end group attached to a majority of the ends of the arboresent polymer, the end group comprising an alkyl cyanoacrylate. The composition may further include a blend of the end-functionalized arborescent polymer with an independent alkyl cyanoacrylate. | 11-19-2015 |
| 20150343113 | POLYMERIC SEALANT FOR USE IN MAMMALS (AS AMENDED) - The invention provides a polymeric medical sealant for use in mammals other than humans. The medical sealant is useful for application to the tonsils, adenoids or paranasal sinus, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing, f) promotion of healing, and g) reduction of pain. | 12-03-2015 |
| 20160184474 | LOW SWELL TISSUE ADHESIVE AND SEALANT FORMULATIONS - A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydrogel to inhibit complications, such as fibrosis, including scar formation or surgical adhesions. | 06-30-2016 |
