| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424900370 | Imageable halogen containing | 23 |
| 20080260650 | Methods of Detection and Therapy of Inflamed Tissues Using Immune Modulation - The present invention relates to methods for the detection and therapy of inflamed tissue, whereby immune modulators are used to increase the uptake of diagnostic or therapeutic compositions by inflammatory cells. | 10-23-2008 |
| 20080292557 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MEDICAL IMAGING OF PARKINSON'S DISEASE - Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved. | 11-27-2008 |
| 20080317675 | Low Osmolar X-Ray Contrast Media Formulations - The present invention generally relates to nonionic x-ray contrast media formulations, radiological compositions containing such agents and methods for x-ray visualization utilizing such compositions. The invention especially relates to injectable radiological compositions for x-ray visualization comprising a pharmaceutically acceptable vehicle and a mixture of a monomer, being a triiodo-substituted benzene nucleus, and a dimer, being two linked triiodo-substituted benzene nuclei, such that the mixture demonstrates favorable properties. | 12-25-2008 |
| 20090074673 | Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques - The disclosure provides, in part, compositions and methods for producing cellular labels for tracking cells by MRI. The disclosure provides, in part, methods for labeling, detecting and quantifying cell numbers in vivo. | 03-19-2009 |
| 20090196830 | ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI - The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non-responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts. | 08-06-2009 |
| 20090214440 | Method and device for examining a biological tissue - The invention relates to a method and a device for analyzing a biological tissue, whereby a luminescence light of a luminescence substance is detected. The aim of the invention is to increase the precision and reliability of the analysis. To this end, a permutation symmetry imbalance is generated in the tissue by a magnetic field, the permutation symmetry imbalance is modified at a pre-determined location by a magnetic alternating field, and the luminescence light is detected according to the pre-determined location. | 08-27-2009 |
| 20090263329 | CELL LABELING WITH PERFLUOROCARBON NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY - Methods of obtaining cells internally labeled with perfluorocarbon nanoparticles suitable for magnetic resonance imaging and spectroscopy are disclosed. Also disclosed are methods for obtaining magnetic resonance imaging data from labeled under clinically relevant scan times and field strengths. Finally, the application further discloses methods of specifically detecting and distinguishing magnetic resonance imaging and spectroscopy data from two distinct sets of cells labeled with distinct types of perfluorocarbon nanoparticles. | 10-22-2009 |
| 20100040556 | CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems. | 02-18-2010 |
| 20100135913 | Ionic and Non-Ionic Radiographic Contrast Agents for Use in Combined X-ray and Nuclear Magnetic Resonance Diagnostics - The invention concerns a method for obtaining diagnostic images of a human or animal body organ, region, fluid or tissue by using combined X-ray and/or Magnetization Transfer (MT) based MRI techniques and iodinated radiographic compounds as contrast agents, as well as improved Chemical Exchange dependent Saturation Transfer (CESDT or CEST) based MRI procedures in which a iodinated contrast agents is used for in vivo determining a physiological parameter of diagnostic interest. | 06-03-2010 |
| 20110110867 | MULTIMODAL IMAGING METHOD USING NANO-EMULSION COMPRISING OPTICAL NANO-PARTICLES AND PERFLUOROCARBONS - The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted. | 05-12-2011 |
| 20110177005 | STABLE NANOEMULSIONS FOR ULTRASOUND-MEDIATED DRUG DELIVERY AND IMAGING - Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents. | 07-21-2011 |
| 20110212031 | NOVEL SUBSTITUTED AZABENZOXAZOLES - The present invention relates to novel MAO-B binding compounds and methods for measuring effects of the compounds, by measuring changes of MAO-B levels in living patients. More specifically, the present invention relates to use of the compounds of this invention as therapeutic agents for inhibition of MAO-B activity as well as a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study MAO-B levels in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel MAO-B binding compounds as diagnostic, as we a therapeutic, agents. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds. | 09-01-2011 |
| 20120148500 | Use of a Fluorinated Polymer as a Contrast Agent in Solid State 19F Magnetic Resonance Imaging (MRI), Scaffold Comprising Said Polymer and Use Thereof - A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent in | 06-14-2012 |
| 20120189552 | COMPOSITIONS AND METHODS USING MICROSPHERES AND NON-IONIC CONTRAST AGENTS - The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed. | 07-26-2012 |
| 20130302253 | CARRIERS FOR THE LOCAL RELEASE OF HYDROPHILIC PRODRUGS - Disclosed is a carrier for the local, targeted administration of a hydrophobic drug. The hydrophobic drug is rendered in to a hydrophilic prodrug thereof, and is contained in the lumen of a thermosensitive liposome or polymersome. Upon administration of the carrier, heat can be applied at the locus where the drug is to be released. After release of the prodrug, it will be activated so as to turn into the active drug. | 11-14-2013 |
| 20130315841 | FUNCTIONALIZED NAPHTHALENE FLUOROPHORES - Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted. | 11-28-2013 |
| 20140234224 | COMPOSITIONS AND METHODS FOR MOLECULAR IMAGING OF OXYGEN METABOLISM - Provided are compositions containing an emulsion containing a perfluorinated compound, as well as methods for preparation of the compositions. Also provided are formulations containing a complex of oxygen-17 and the emulsion compositions. Additionally provided are methods for the preparation of the formulations as well as kits containing the formulations. Further provided are methods of use of the formulations in imaging of tissues using a magnetic resonance imaging system. | 08-21-2014 |
| 20140314678 | COMPOSITIONS AND METHODS USING MICROSPHERES AND NON-IONIC CONTRAST AGENTS - The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed. | 10-23-2014 |
| 20150132228 | COMPOSITIONS AND METHODS TO EVALUATE HEPATOBILIARY/GASTROINTESTINAL HEALTH, ENTEROHEPATIC CIRCULATION, AND DRUG INTERACTIONS - The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a | 05-14-2015 |
| 20150314020 | COMPOSITIONS AND METHODS USING MICROSPHERES AND NON-IONIC CONTRAST AGENTS - The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed. | 11-05-2015 |
| 20150352232 | MR IMAGING DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASE - Disclosed is a compound represented by formula (1) or a salt thereof, | 12-10-2015 |
| 20160000941 | Semifluorocarbon Compound Containing Contrast Agent - The present invention relates to an aqueous emulsion comprising a) a semifluorinated compound of formula I: CF | 01-07-2016 |
| 20160046666 | FUNCTIONALIZED NAPHTHALENE FLUOROPHORES - Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted. | 02-18-2016 |
