| Entries |
| Document | Title | Date |
|---|
| 20080206151 | Liposomes - The present invention relates to a process for the manufacture of targeting liposomes comprising vector compounds conjugated to the hydrophilic part of modified phospholipids. The present invention provides the modified phospholipids and liposomes containing said modified phospholipids. | 08-28-2008 |
| 20080241072 | INJECTABLE VOID FILLER FOR SOFT TISSUE AUGMENTATION - The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present application exhibits physical characteristics, such as mechanical properties, typically seen in elastomers and mechanical stability, which is superior to fibrin alone. A variety of properties of the composition of the present invention can be effectively fine-tuned and altered by adjusting type and content of the particles as well as of the plasticizer contained in the void filler composition. | 10-02-2008 |
| 20080260649 | Method of Dynamic Nuclear Polarisation DNP - The invention relates to a method of dynamic nuclear polarisation (DNP) using a combination of a trityl radical and a paramagnetic metal ion as the polarising agent leading to enhanced levels of polarisation in the sample to be polarised and to compositions and polarising agents for use in the method. | 10-23-2008 |
| 20080279782 | POLYMERS CONJUGATED WITH PLATINUM DRUGS - Various biocompatible polymers having platinum compounds conjugated thereto are prepared. Such polymers are useful for a variety of drug, biomolecule, and imaging agent delivery applications. Also disclosed are methods of using the polymers to treat, diagnose, and/or image a subject. | 11-13-2008 |
| 20090169484 | IRON-SALEN COMPLEX - The present invention provides a drug delivery system that overcomes conventional technical problems and that is readily put to practical use. Iron-salen complexes represented by General Formula (I) below. The invention renders iron-salen complexes magnetic, which can thus be used as drugs that can be delivered to affected areas in the body using the inherent magnetic properties of the drug without employing carriers composed of magnetic substances as has been done hitherto. | 07-02-2009 |
| 20090180966 | Cancer cell diagnosis by targeting delivery of nanodevices - Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line. | 07-16-2009 |
| 20090246144 | SYSTEM AND METHOD FOR INDIRECTLY MEASURING CALCIUM ION EFFLUX - A system and method for indirectly measuring calcium ion efflux from a cell of a subject by using manganese ions as a surrogate marker for calcium is disclosed. Manganese ion efflux is measured with a MEMRI T | 10-01-2009 |
| 20090304600 | Intradialytic administration of sodium thiosulfate - The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the blood of toxic and metabolic waste in patients undergoing hemodialysis, peritoneal dialysis, or gastrointestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. In the method of the invention, dialysis solution components contain therapeutic amounts of sodium thiosulfate, which when fully reconstituted for use as a single solution, deliver 20-130 mg/dl of dialysate. | 12-10-2009 |
| 20100040555 | Magnetic Nanoparticles Compositions and Uses Thereof - The present invention relates to the use of a biocompatible nanoparticle or nanoparticle aggregate, in combination with an external non-oscillating magnetic field, wherein said nanoparticle comprises: a) a core comprising magnetic material; b) a biocompatible shell surrounding the core, and, optionally; c) a labelling agent wherein the outer diameter of the shell is less than about 100 nm, to prepare a composition, wherein the composition is deprived of any cell targeting means. The present invention further relates to the compositions thus obtained and to their uses in the field of human health, for the treatment of cancer, or in diagnostic (imaging for example), for the monitoring of tumor evolution. | 02-18-2010 |
| 20100055042 | Enhancing Clot Busting Medication in Stroke with Directed Drug Convection using Magnetic Nano-Particles - An important step towards successful drug targeting with nanoparticles is developing a method to coat the nanoparticles with a useful drug. BSA was used by us to mimic the actual drug for its cost effectiveness during initial trials. We have successfully immobilized BSA onto three (PEG, PEMA and glutamic acid) out of four different surfactant capped nanocomposites. We found that the BSA immobilized particles showed excellent colloidal stability in water and stayed well suspended without any sign of agglomeration or settling. The suspended particles were easily accumulated using a magnet and could be re-dispersed readily. These properties indicate that the BSA immobilized iron oxide nanocomposites are excellent candidates for directed drug convection (DDC). | 03-04-2010 |
| 20100061937 | DELIVERY OF CONTRASTING AGENTS FOR MAGNETIC RESONANCE IMAGING - Erythrocytes exposed to dialysis with an hypotonic buffer stably take up superparamagnetic iron oxide nanoparticles and may be used MRI contrast agents. Such erythrocytes may also be used as drug delivery vehicles. | 03-11-2010 |
| 20100098639 | Compositions and Methods for Convection Enhanced Delivery of High Molecular Weight Neurotherapeutics - A method of therapeutic treatment of CNS disorders using local convection enhanced delivery. | 04-22-2010 |
| 20100158812 | Anti-Cancer Medicine Both for Diagnosing and Treating Cancer - Disclosed is an anti-cancer medicine comprising a chain end functionalized polymer, a contrast material such as iron oxide and a chemotherapeutic agent such as doxorubicin or pharmaceutically acceptable salts thereof. The anti-cancer medicine performs diagnosis and treatment of cancer at the same time, remarkably reduces a cardiotoxic side effect of the doxorubicin and has an excellent targeting function to the cancer part to considerably increase the anti-cancer effect. At the same time, the anti-cancer medicine is provided as MRI contrast medium which can diagnose the cancer and monitor a progress of the disease. In particular, the anti-cancer medicine is disclosed which is superior to the diagnosis and treatment of the solid cancer and can effectively perform the diagnosis and treatment of the metastatic cancer as well as the primary cancer at the same time. | 06-24-2010 |
| 20100166667 | MAGNETIC RESONANCE IMAGING - A method of determining the amount of intracellular manganese in the myocardium of an individual pre-administered with a manganese contrast agent, or a pharmaceutically acceptable salt thereof, comprising subjecting said individual to a MRI procedure to assess the signal intensity (SI) of images, or more preferably the longitudinal relaxation rate, R | 07-01-2010 |
| 20100196283 | METHOD AND IMAGING MEDIUM FOR USE IN THE METHOD - The invention relates to a method of | 08-05-2010 |
| 20100215587 | MATERIALS AND METHODS FOR MRI CONTRAST AGENTS AND DRUG DELIVERY - A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T | 08-26-2010 |
| 20100233096 | METHOD TO PRODUCE HYPERPOLARISED CARBOXYLATES AND SULPHONATES - The invention relates to a dynamic nuclear polarisation method for producing hyperpolarised carboxylates or sulphonates or mixtures thereof wherein the carboxylate or sulphonate used in the method of the invention comprises certain inorganic cations. The invention further relates to compositions for use in that method. | 09-16-2010 |
| 20100254912 | Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity | 10-07-2010 |
| 20100303731 | Systems, devices, methods, and compositions including selectively accessible ferromagnetic structures - Magnetic resonance systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids. In an embodiment, a plurality of ferromagnetic microstructures includes one or more selectively accessible ferromagnetic microstructures. | 12-02-2010 |
| 20100322867 | BIOMEDICAL MATERIALS - A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprise a compound having the general chemical formula: Ca | 12-23-2010 |
| 20110033390 | MR IMAGING AGENT OR MEDIUM COMPRESSING HYPERPOLARISED 13C ALANINE AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED - The invention relates to hyperpolarised | 02-10-2011 |
| 20110038804 | MR IMAGING AGENT, IMAGING MEDIUM AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED - The invention relates to hyperpolarised | 02-17-2011 |
| 20110117028 | DEVICE AND METHOD FOR IN VIVO NONINVASIVE MAGNETIC MANIPULATION OF CIRCULATING OBJECTS IN BIOFLOWS - A device and methods for the non-invasive manipulation and detection of target objects such as cells, pathogens, microparticles, and nanoparticles in vivo using an external magnetic field are described. In one aspect, a device and method for capturing and detecting intrinsically magnetic target objects or target objects labeled with at least one magnetic particle within the area of interest using an in vivo flow cytometer are described. | 05-19-2011 |
| 20110243858 | HYDROXYLATED CONTRAST ENHANCEMENT AGENTS AND IMAGING METHOD - A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof | 10-06-2011 |
| 20120027690 | PH-SENSITIVE GRAFT COPOLYMER, MANUFACTURING METHOD FOR SAME, AND POLYMER MICELLES USING METHOD - The present document relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer. The pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. The pH-sensitive graft copolymer forms micelles that can be used in target-oriented diagnosis and medicine release according to changes in the pH of a body. The polymer micelles are provided by inducing a graft copolymer of poly(β-amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic poly(ethylene glycol) compounds. | 02-02-2012 |
| 20120070383 | POLYMERIC NANO-CARRIERS WITH A LINEAR DUAL RESPONSE MECHANISM AND USES THEREOF - The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nano-carriers that are degraded by lower pH and/or ROS. | 03-22-2012 |
| 20120189551 | MRI Markers, Delivery and Extraction Systems, and Methods of Manufacture and Use Thereof - Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices. | 07-26-2012 |
| 20120269736 | MICELLAR COMPOSITIONS FOR USE IN BIOLOGICAL APPLICATIONS - This invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence or fluorescence from about 300 nm to about 1500 nm of the electromagnetic spectrum: a biocompatible surfactant and/or lipid: and a MRI active agent. | 10-25-2012 |
| 20130089505 | SINGLE VIAL FORMULATION FOR MEDICAL GRADE CYANOACRYLATE - Alkyl cyanoacrylate compositions and methods for making those compositions, utilizing high purity monomeric starting materials, formed into more viscous oligomers, and combined with a plasticizer and inhibitor to provide a single-container, storage stable medical cyanoacrylate. | 04-11-2013 |
| 20130129634 | INTRINSICALLY MAGNETIC HYDROXYAPATITE - The present invention relates to hydroxyapatite doped with Fe | 05-23-2013 |
| 20130336897 | THERANOSIS OF MACROPHAGE-ASSOCIATED DISEASES WITH ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (USPIO) - Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in their lysosomes. The amount of USPIO loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal. Both fixed macrophages and activated macrophages associated with inflammatory diseases and cancer phagocytize USPIOs, and the loaded macrophages can serve to identify the extent of a macrophage-dependent disease as well as to direct treatment options. Furthermore, the absorption of energy from incident electromagnetic waves by the aggregated nanoparticles can be used for conformal thermotherapy. The USPIOs can further be used to carry drugs to the same activated macrophages. The co-administered drugs can be bound to the USPIO by condition-dependent releasing links that are responsive to local pH or heating. | 12-19-2013 |
| 20130344003 | IMMUNO-THERAPY FOR CANCER TREATMENT USING IRON OXIDE NANOPARTICLES - An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle is administered to a tumor. Once the composition has been administered, it is recommended to avoid any means that would cause direct cytotoxic effects to the cancer cells and to normal/healthy tissue. The combination of composition-administered cancer cells with the avoidance of direct cytotoxic effects has been shown to be successful to inhibit the growth of the cancer cells or result in aptosis of the cancer cells. Additional dose(s) can be administered when it is determined that: (i) the tumor starts to grow and/or (ii) the remaining composition falls below a threshold. The immuno-therapy method is a safe, clinically applicable, ready-to-use theranostic approach for cancer patients who are unable to start chemoradiotherapy in a timely manner, i.e. an effective interim or adjunctive treatment for patients. | 12-26-2013 |
| 20140205543 | METHOD FOR DIAGNOSING OR TREATING TUMORS USING SPHINGOMYELIN CONTAINING LIPOSOMES - The invention provides compositions and methods for diagnosing tumors and augmentic therapeutic intervention and measuring response to cell stress using sphingomyelin containing liposomes. The liposomes can include radiotracers, contrast agents, chromophores, dyes, enzyme substrates, therapeutic agents, chemotherapeutic agents or DNA segments. The indicators enable measurement of the extent of cellular release of Acid SMase at a localized site of cell stress. The nanoparticles have the capacity to locally release their contents, be it imaging (for diagnosis) or therapeutic agents (to augment therapy). | 07-24-2014 |
| 20140234223 | NANOEMULSIONS AND USE THEREOF AS CONTRAST AGENTS - The invention relates to an oil-in-water nanoemulsion for MRI, including:
| 08-21-2014 |
| 20140328766 | COMPOSITION AND METHOD FOR GENERATING A METABOLIC PROFILE USING 13C-MR DETECTION - The invention relates to a method of | 11-06-2014 |
| 20150010477 | Method for the Treatment of Multiple Sclerosis - A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of an IL-21 receptor antagonist, wherein the subject has failed to respond treatment with beta interferon, thereby treating the subject. | 01-08-2015 |
| 20150079005 | POLYMERIC NANOCARRIERS WITH LINEAR DUAL RESPONSE MECHANISM - Nanocarriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nanocarriers that are degraded by lower pH and/or ROS. | 03-19-2015 |
| 20150337044 | Methods for the Treatment of Multiple Sclerosis - A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of an IL-21 receptor antagonist, wherein the subject has failed to respond treatment with beta interferon, thereby treating the subject. | 11-26-2015 |
| 20160136305 | COBALT-BASED MRI CONTRAST AGENT AND IMAGING SYSTEM - Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices. | 05-19-2016 |
| 20160200670 | RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO | 07-14-2016 |
