| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424900350 | Carbohydrate or derivative thereof attached to or complexed with the agent | 26 |
| 20080279781 | Glycosylated Carboranylporphyrins and Uses Thereof - The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity glycosylated carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, and head and neck. The invention is also directed to using these glycosylated carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. | 11-13-2008 |
| 20090004118 | Multifunctional Nanoparticle Conjugates And Their Use - Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods for using the conjugates to deliver therapeutic and/or imaging agents to cells. Also disclosed are methods for using the conjugates to treat particular disorders, such as proliferative disorders. | 01-01-2009 |
| 20090162292 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS - The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A | 06-25-2009 |
| 20090196829 | MRI CONTRAST AGENTS AND RELATED METHODS OF USE - The present invention relates to contrast agents for MRI and related methods of use. | 08-06-2009 |
| 20090214439 | Fluorinated Carbohydrates and Their Use in Tumor Visualization, Tissue Engineering, and Cancer Chemotherapy - The present invention relates to fluorine-containing monosaccharides that are useful for forming extracellular fluorinated glycoconjugates. Methods of forming extracellular fluorinated glycoconjugates comprise the steps of contacting a cell with a fluorine-containing monosaccharide, and incubating the cell under conditions whereby the cell internalizes the fluorine-containing monosaccharide, or a derivative thereof, on the surface of the cell. The present invention also relates to the use of a fluorine-containing monosaccharide in cellular imaging using fluorine NMR. The invention additionally relates to the use of fluorine containing monosaccharides in the treatment of cancer and inflammatory disease. | 08-27-2009 |
| 20090220433 | Novel biotinylated compositions - Novel biotinylated composition comprising a nucleic acid, e.g. siRNA, that are useful for targeting therapeutic and imaging agents to sites of infection and tumors are disclosed. | 09-03-2009 |
| 20100015057 | MAGNETORESONANCE PREPARATIONS, DEVICE FOR INDIVIDUALLY SELECTING SAID PREPARATIONS FOR INCREASING AN ORGANISM LIFE ACTIVITY IN ACTUAL ENVIRONMENTAL CONDITIONS - The invention concerns to area of pharmacy, biological physics and biodiagnostics, more exactly to development of preparations having ability of magnetic-resonance exposure on micro- and macro organisms with the purpose of activation and protection of their vital activity in conditions of ecological environment at the expense of individual selection of such preparations with the help of the special device. The problem of stability of exposure on biological object with the simple and very habitual for use, universalised, portable, marked if necessary, agent of activation of vital activity of biological object at an ecological level is not solved in any known development. Therefore the first task of the present invention is the creation of universal portable preparation for activation of vital activity of biological object with the help of the physiological carrier capable to be marked, to work in a wide range of an electromagnetic field (EMF) and to keep stable initial properties for a long time during storage. Other task is the creation of a similar preparation capable to work in a wide spectrum of a variable magnetic field (VMF). Both types of preparations are capable to activate the vital activity of organisms, intensifying energetic activity of organism, including accelerating elimination of the harmful foreign agents. Those or other preparations are chosen with the help of the magnetic resonance device capable to find out the foreign agent in the organism being investigated. | 01-21-2010 |
| 20100034751 | DEHYDRATED GRANULAR COMPOSITION AND BIOMEDICAL APPLICATIONS THEREOF - The invention relates to a granular composition for a biomaterial, that comprises from 0.1 to 5 wt % of at least one polymer derived from cellulose, 75 to 99.9 wt % of a mineral phase containing hydroxyapatite and/or β tricalcic phosphate, and 0 to 10 wt % of water, preferably 0 to 7 wt % of water, more preferably 0 to 5 wt % of water, and even more preferably approximately 5 wt % of water. | 02-11-2010 |
| 20100055040 | Optical Imaging Contrast Agents - The present invention provides compositions and methods for the selective identification of damaged sites in the gastrointestinal tract. More particularly, the compositions comprise a phosphated and/or sulfated saccharide, such as sucralfate, containing one or more optical molecules. | 03-04-2010 |
| 20100055041 | NANOTRACER FOR IN-SITU GASTRIC CANCER DETECTION - Nanotracers for in-situ detection of cancerous gastric tissue include substantially monodisperse polymeric nanoparticles, at least one detectable label incorporated into each particle, and receptor-specific ligands coupled to each nanoparticle. The receptor-specific ligand is selected such that it interacts preferentially with ligand-specific receptors that are overexpressed on cancerous cells. | 03-04-2010 |
| 20100239504 | IMAGING NUCLEIC ACID BINDING PROTEINS - Reporter conjugates for non-invasive in vivo detection, e.g., imaging, of expression or activity of nucleic acid binding proteins are disclosed. The conjugates include a targeting nucleic acid linked to a reporter group, e.g., a contrast agent, such as a paramagnetic label that can be used with magnetic resonance imaging. The targeting nucleic acid can be a double-stranded nucleic acid that binds to the nucleic acid binding protein the expression of which is to be imaged. In some embodiments, the contrast agent is a chelated metal such as gadolinium or dysprosium. The invention also features methods to image protein expression in various tissues, including the brain, and therapeutic methods. | 09-23-2010 |
| 20110104076 | Compositions, Methods For Preparing Amino Acids And Nuclear Magnetic Resonance Spectroscopy - The present invention relates to amino acids, complexes, and compounds comprising deuterium and tritium isotopes preferably alpha deuterated amino acids, polypeptides, antibodies, derivatives and saccharide-amino acid complexes and conjugates. In some embodiments, the invention relates to methods of using compounds comprising deuterium for imaging biochemical concentrations and distributions in mammalian tissues using nuclear magnetic resonance spectroscopy. In some embodiments, the invention relates to the used of said amino acids derivatives and complexes in boron neutron capture therapy. In some embodiments, the present invention relates to the preparation of amino acids, polypeptides, antibodies, derivatives and saccharide complexes/conjugates comprising heavy hydrogen isotopes. In some embodiments, the invention relates to racemizing amino acids starting from compositions of any optical purity. In further embodiments, the invention relates to the preparation of amino acids and their N-acyl counterparts with deuterium incorporated at the alpha carbon. | 05-05-2011 |
| 20110117027 | INJECTABLE VOID FILLER FOR SOFT TISSUE AUGMENTATION - The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present application exhibits physical characteristics, such as mechanical properties, typically seen in elastomers and mechanical stability, which is superior to fibrin alone. A variety of properties of the composition of the present invention can be effectively fine-tuned and altered by adjusting type and content of the particles as well as of the plasticizer contained in the void filler composition. | 05-19-2011 |
| 20110177004 | Version of FDG Detectable by Single-Photon Emission Computed Tomography - A compound comprising a metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent is provided. The compound is suitable for imaging by single-photon emission computed tomography, computer assisted tomography, magnetic resonance spectroscopy, magnetic resonance imaging, positron emission tomography, fluorescence imaging or x-ray. | 07-21-2011 |
| 20110212030 | Nucleic Acid Ligand Complexes - This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound. | 09-01-2011 |
| 20110243857 | SMART CONTRAST AGENTS FOR MRI IMAGING - A contrast agent for MRI imaging includes: (a) one cyclodextrin, whose truncated-cone-shaped structure defines a central axis, a first and a second openings along the axis, (b) one paramagnetic element, located on the cyclodextrin axis, outside the structure and proximate to the first opening, (c) one or several coordination ligand(s) of the paramagnetic element which coordinate(s) the paramagnetic element, (d) one arm covalently bound to the cyclodextrin, proximate to the second opening, which is able to form an inclusion complex with the cyclodextrin. | 10-06-2011 |
| 20110256067 | Contrast agents endowed with high relaxivity - The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity. | 10-20-2011 |
| 20120058054 | GADOLINIUM COMPLEX, METHOD FOR PREPARING SAME, AND MRI CONTRAST AGENT COMPRISING SAME - Disclosed are a gadolinium complex formed by coordination of gadolinium to the diethylenetriaminepentaacetic acid dianhydride (DTPA) moiety of a pullulan-DTPA conjugate formed by an ester bond between pullulan and DTPA, a preparation method thereof, an MRI contrast composition comprising the complex, and a method of providing information for diagnosis of disease using the complex as an MRI contrast agent. The pullulan-DTPA-Gd complex has a long in vivo half-life, low toxicity, and high MRI signal intensity resulting in clear MRI images, compared to prior gadolinium complexes, indicating that it is advantageously used as an MRI contrast agent. In addition, it is possible to obtain MRI images allowing one to differentiate between diseased liver tissue and normal liver tissue, indicating that it is used as an MRI contrast agent for the liver. | 03-08-2012 |
| 20120207684 | COMPOSITION AND METHODS FOR IMAGING CELLS - A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell. | 08-16-2012 |
| 20120258050 | 13C-MR DETECTION USING HYPERPOLARISED 13C-FRUCTOSE - The invention relates to a method of | 10-11-2012 |
| 20130230468 | ISOTOPICALLY LABELED DEOXY-GLUCOSE AND DERIVATIVES THEREOF, COMPOSITIONS COMPRISING THEM AND USES THEREOF - The present invention provides isotopically labeled deoxy-glucose and derivatives thereof, methods of their preparation, ration, kits comprising them and uses thereof for spin hyperpolarized magnetic resonance imaging, utilized in the quantitative and qualitative diagnosis of states, conditions, diseases, or disorders in the body of a subject. | 09-05-2013 |
| 20140154185 | USE OF NON-LABELED SUGARS AND DETECTION BY MRI FOR ASSESSING TISSUE PERFUSION AND METABOLISM - A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal. | 06-05-2014 |
| 20160082133 | CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) BASED MRI USING REPORTER GENES AND SUBSTRATES AND METHODS THEREOF - The present invention features polypeptide or protein based reporters, wherein the MRI contrast is generated by the protein itself, and methods, MRI systems and MRI imaging kits related thereto. The present invention also features enzyme based reporters, wherein the contrast is generated by the substrate/product of an enzyme, and methods, MRI systems and MRI imaging kits related thereto. | 03-24-2016 |
| 20160095945 | USE OF NON-LABELED SUGARS AND DETECTION BY MRI FOR ASSESSING TISSUE PERFUSION AND METABOLISM - A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal. | 04-07-2016 |
| 20160199517 | MRI EVALUATION OF HETEROGENEOUS TISSUE | 07-14-2016 |
| 424900351 | The region of the imaging agent responsibile for binding to an in vivo target or the region of the target responsible for binding to the agent is specifically recited functionally or as a sequence of amino acids, carbohydrate residues, or nucleic acids | 1 |
| 20140056822 | DNA Dendrimers as Thermal Ablation Devices - DNA dendrimers for targeted delivery of radiation absorbing nanoparticles and thermal ablation of cells and tissues are provided. Also provided are methods of making and methods of using the DNA dendrimers. | 02-27-2014 |
