| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 424900330 | Nitroxide or nitroxide containing | 6 |
| 20090028798 | METHOD FOR DETERMINING REDOX STATUS OF A TISSUE - Disclosed is a method for determining the redox status of a region of interest in an animal tissue. The method includes administering a nitroxyl contrast agent to the region of interest, obtaining a magnetic resonance image of the region of interest, determining the amount of reduced nitroxyl contrast agent in the region of interest, and thereby determining the redox status of the region of interest. | 01-29-2009 |
| 20090214437 | In Vivo Mitochondrial Labeling Using Positively-Charged Nitroxide Enhanced and Gadolinium Chelate Enhanced Magnetic Resonance Imaging - A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity. | 08-27-2009 |
| 20100260684 | USE OF 3-ALKANOYLOXYMETHOXYCARBONYL NITROXIDE ESTERS AS OXIMETRY PROBES FOR MEASUREMENT OF OXYGEN STATUS IN TISSUES - The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O | 10-14-2010 |
| 20100310471 | ANTIOXIDANT AND PARAMAGNETIC HEPARIN-NITROXIDE DERIVATIVES - The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as therapeutic or diagnostic agents. This invention further concerns novel methods for the production of the heparin-nitroxide agents, and methods of their uses for specifically targeting and labelling of biological vessels. The inventions also suggest the uses of the heparin-nitroxide derivatives for treatment of oxidative stress-mediated diseases. Furthermore, the heparin-nitroxide derivatives according to the present invention are in particular useful for electron paramagnetic resonance imaging (EPRI), for magnetic resonance imaging (MRI), and for preservation of biological transplants. | 12-09-2010 |
| 20110165087 | TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGING - The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue. | 07-07-2011 |
| 20130142735 | In Vivo Mitochondrial Labeling Using Positively-CHarged Nitroxide Enhanced and Gadolinum Chelate Enhanced Magnetic Resonance Imaging - A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity. | 06-06-2013 |
