| Entries |
| Document | Title | Date |
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| 20080206150 | Nanoparticles for Imaging Atherosclerotic Plaque - Atherosclerosis is an inflammatory disease of the arterial walls and represents a significant health problem in developed nations. Described is a targeted Magnetic Resonance Imaging (MRI) contrast agent for in vivo imaging of early stage atherosclerosis. Early plaque development is characterized by the influx of macrophages, which express a class of surface receptors known collectively as the scavenger receptors (SR). The macrophage scavenger receptor class A (SRA) is highly expressed during early atherosclerosis. The macrophage SRA therefore presents itself as an ideal target for labeling of lesion formation. By coupling a known ligand for the scavenger receptor, dextran sulfate, to a MRI contrast agent, early plaque formation can be detected in vivo. Targeted MR contrast agents offer a unique opportunity to visualize early plaque development in vivo with high sensitivity and resolution, allowing or early diagnosis and treatment of atherosclerosis. | 08-28-2008 |
| 20080213189 | Multifunctional metal-graphite nanocrystals - Disclosed are nanocrystals comprising metals and metal alloys, which are formed by a process that results in a layer of graphite in direct contact with the metallic core. The nanocrystals may be used in vivo as MRI contrast agents, X-ray contrast agents, near IR (NIR) heating agents, drug delivery, protein separation, catalysis etc. The nanocrystals may be further functionalized with a hydrophilic coating, e.g., phospholipid-polyethylene glycol, which improves in vivo stability. The process comprises chemical vapor deposition of metals adsorbed onto silica as a fine powder, in conjunction with a carbon containing gas, which coats the metal particles. The silica is then etched away. Preferred metals include iron, gold, cobalt, platinum, ruthenium and mixtures thereof, e.g., FeCo and AuFe. The process permits control of the alloy compositions, size, and other characteristics. | 09-04-2008 |
| 20080260648 | Pharmaceutical Preparation Containing Magnetic Vesicular Particles, Manufacturing Method Thereof and Diagnostic Therapeutic System - A pharmaceutical preparation containing magnetic vesicular particles is disclosed, wherein the magnetic vesicular particles each include magnetic microparticles within a lipid membrane, an organic compound having at least two groups selected from the group consisting of a hydroxyl group, a carboxyl group, a carbamoyl group, an amino group, a mercapto group, a sulfo group, a dithio group, a thiocarboxyl group and a dithiocarboxyl group is bonded to the magnetic microparticle, and the magnetic vesicular particles satisfy the following equation: | 10-23-2008 |
| 20080299046 | METHODS FOR CONTROLLING SURFACE FUNCTIONALITY OF METAL OXIDE NANOPARTICLES, METAL OXIDE NANOPARTICLES HAVING CONTROLLED FUNCTIONALITY, AND USES THEREOF - Methods for controlling surface functionality of metal oxide nanoparticles, nanoparticles having controlled surface functionality, and uses thereof are described herein. Methods for controlling the surface functionality of a metal oxide nanoparticle are can include attaching a ligand to a metal oxide nanoparticle, where the ligand can include a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Moreover, metal oxide nanoparticles having versatile ligands can include an anchoring portion that binds to the surface of the metal oxide nanoparticle and a functional portion that is capable of forming an irreversible bond with an object at a site that is complementary to the functional portion without reacting with other reactive sites that may be present. Uses thereof can include cancer detection, electronics, cosmetics, cellular delivery carriers, magnetic storage media, drug delivery carriers, nanocomposite formation for improved mechanical properties, and the like. | 12-04-2008 |
| 20080299047 | Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof - The present invention relates to a process for preparing water-soluble and dispersed iron oxide (Fe | 12-04-2008 |
| 20080305048 | Self-Assembling Nanoparticle Conjugates - This invention relates to magnetic nanoparticle conjugates and related compositions and methods of use. | 12-11-2008 |
| 20080311048 | Imaging Agent - The invention provides a conjugate comprising an iron containing colloidal particle, the particle being conjugated to one or more sugar targeting moieties. The conjugate is useful as a contrast agent in medical imaging, particularly in magnetic resonance imaging (MRI). The agents of the present invention may cross the blood brain barrier and so may be particularly useful in the monitoring or diagnosis of conditions affecting the brain. | 12-18-2008 |
| 20090047220 | CONTRAST MEDIUM FOR ADMINISTRATION TO A PATIENT FOR MAGNETIC RESONANCE IMAGING - An exemplary contrast medium for administration to a patient for magnetic resonance imaging is shown. The contrast medium includes: a plurality of carbon nanospheres; and an iron containing nano-particle embedded in each of the carbon nanospheres. | 02-19-2009 |
| 20090060844 | METHOD AND CONTRAST AGENT FOR IMAGING A PROSTATE TUMOR - In a method for imaging a prostate tumor in which a contrast agent that can be distributed via the circulatory system is administered to the patient, the contrast agent contains at least one type of biomarkers which are bound to a ferromagnetic particle and specifically bind to a target molecule typical of the tumor and formed within the tumor or in a tissue adjacent to the tumor. The imaging ensues with the use of magnetic resonance tomography. | 03-05-2009 |
| 20090060845 | DIAGNOSIS SUBSTANCE FOR APPLICATION IN A METHOD TO DIAGNOSIS PATHOLOGICAL TISSUE AND A METHOD FOR PRODUCTION OF SUCH A DIAGNOSIS SUBSTANCE - A diagnosis substance for application in a method for diagnosis of pathological tissue, contains at least one virus population with virus particles specifically binding to target molecules typical of a specific pathological tissue, with a label that is detectable with the use of a detection device being bound to the virus particles. In a method for production of such a diagnosis substance, the principle of directed biological evolution is applied. | 03-05-2009 |
| 20090060846 | NANOPARTICLES HAVING REACTIVE ESTER GROUPS COVALENTLY COUPLED THERETO AND RELATED METHODS - A particle having a core and a surface to which are covalently coupled a plurality of reactive ester groups. Methods for using the particle to prepare a particle having one or more of a plurality of a targeting agent, a diagnostic agent, or a therapeutic agent covalently coupled thereto. | 03-05-2009 |
| 20090068114 | Noninvasive Thermometry Monitoring System - A noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered is disclosed. The monitoring system may incorporate magnetic nanoparticles having known moments such that once exposed to an alternating magnetic field, the magnetic nanoparticles increase in temperature. Imaging systems can disclose the magnetic nanoparticles within a patient. The temperature of the magnetic nanoparticles can be determined by comparing the magnetic nanoparticle with known temperatures for that type of magnetic nanoparticle. The image of the magnetic nanoparticles may be compared with surrounding tissue to determine the temperature of the surrounding tissue that is exposed to hyperthermia treatment. | 03-12-2009 |
| 20090104124 | Paramagnetic Complexes with Pendant Crown Compounds Showing Improved Targeting- Specificity as MRI Contrast Agents - Potential magnetic resonance imaging (MRI) contrast agents that are functionalized with crown compounds have been synthesized, and show target-specificity to the kidney and liver, along with excellent water solubility, high MR intensity enhancement efficiency, long resident lifetime, low dosage requirement, low cytotoxicity and prolonged excretion rate. | 04-23-2009 |
| 20090110642 | METHOD FOR THE PRODUCTION OF BIO-IMAGING NANOPARTICLES WITH HIGH YIELD BY EARLY INTRODUCTION OF IRREGULAR STRUCTURE - Methods of preparing bio-imaging nanoparticles having high dispersibility in an aqueous solution, biocompatibility, and targetability with high yield, by early introduction of an irregular structure are disclosed. | 04-30-2009 |
| 20090123384 | METHOD FOR MAGNETIC RESONANCE IMAGING USING STIMULUS INDUCED ROTARY SATURATION WITH A CONTRAST AGENT - A method and system for producing an image of a subject with a magnetic resonance imaging (MRI) system, in which the presence of a contrast agent is detected using a spin-lock pulse sequence, is described. More specifically, a contrast agent that induces saturation of magnetic resonance signals responsive to a spin-lock condition is administered to a subject. A spin-lock condition is subsequently established to saturate spins in proximity to the contrast agent. Image data is then acquired with an imaging pulse sequence and images indicative of the presence of the contrast agent are reconstructed. | 05-14-2009 |
| 20090220431 | MAGNETIC RESONANCE IMAGING CONTRAST AGENTS CONTAINING WATER-SOLUBLE NANOPARTICLES OF MANGANESE OXIDE OR MANGANESE METAL OXIDE - The present invention relates to a manganese-containing metal oxide nanoparticle-based magnetic resonance imaging (MRI) contrast agent, which is characterized in that: The core of it comprises 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles which include MnO a (0| 09-03-2009 | |
| 20090238767 | TARGETING CONTRAST AGENTS OR TARGETING THERAPEUTIC AGENTS FOR MOLECULAR IMAGING AND THERAPY - This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use. | 09-24-2009 |
| 20090246143 | NON-RADIOACTIVE TRACEABLE METAL ISOTOPE-ENRICHED NANOPARTICLES AND METHOD OF THEIR USE FOR DETERMINING BIODISTRIBUTION - Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes. | 10-01-2009 |
| 20090304599 | Protein Nanoparticles and the Use of the Same - An object of the present invention is to provide nanoparticles that can easily be delivered to a small site such as a capillary and can be produced using highly biocompatible and safe material. The present invention provides a nanoparticle which contains at least one pharmaceutically active component, a magnetically responsive particle, and a protein. | 12-10-2009 |
| 20100008862 | Fluorescent magnetic nanoprobes, methods of making, and methods of use - Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like. | 01-14-2010 |
| 20100047180 | Iron/Iron Oxide Nanoparticle and Use Thereof - The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are disclosed for use in hyperthermia treatment and imaging of cancer. | 02-25-2010 |
| 20100092394 | Multimeric Particles - The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The invention further provides a contrast agent comprising said multimeric particles, along with a method of improving contrast of an image using said contrast agent. | 04-15-2010 |
| 20100119458 | Compositions Containing Metal Oxide Particles and Their Use - A composition of metal oxide nanoparticles in which individual nanoparticles comprises a core that optionally is coated and the metal oxide comprises a metal oxide lattice in which 5 there are two, three, four or more different kinds of metal ions: A) one of these metal ions is selected among lanthanide ions (typically ions of elements 57-B 71), and) at least one, two, three or more of the other different kinds of metal ions is selected among 10) i transition metal ions of elements of Groups 3b-7b, 8, 1b, 2b other than the lanthanide b ions of elements 57-71, and/or A) lanthanide ions other than the kind of lanthanide ion selected in A. typical metal ion of (A) is Gd3+, of (B.a) is Fe3+ and of (B.b) is Tb3+. 1 5A v method for coating core forms of the particles, and the use of the particles for visualizing various kinds of biological material, e.g. by magnetic resonance, are also provided. | 05-13-2010 |
| 20100135912 | MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE - Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. | 06-03-2010 |
| 20100166664 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20100166665 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20100166666 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety. | 07-01-2010 |
| 20100215586 | NOVEL METHOD FOR PREPARING NANOPARTICLES COVERED WITH A GEM-BISPHOSPHONATE STABILIZING LAYER COUPLED TO HYDROPHILIC BIODISTRIBUTION LIGANDS - A novel method for preparing nanoparticles for medical imaging, including a metal core, an organic stabilizing layer containing gem-bisphosphonate compounds and at least one hydrophilic biodistribution ligand. | 08-26-2010 |
| 20100226862 | MICROCAPSULE AND METHOD FOR MAGNETIC RESONANCE IMAGING TO LOCALIZE BLOOD - Microcapsule for injection into the bloodstream of a patient before a magnetic resonance acquisition pertaining to the bloodstream, include a magnetic resonance marking substance (in particular with at least one isotope associated with a specific resonant frequency) inside the microcapsule and an outer membrane that is impermeable to the marking substance. The microcapsule is overall biodegradable. | 09-09-2010 |
| 20100233093 | Magnetic resonance imaging contrast agent with paramagnetic-inositol phosphates complexes - Disclosed are novel MRI contrast agents and imaging methods using the same. The novel MRI contrast agent comprises a chelating molecule with at least two phosphate groups coordinated with at least one paramagnetic substances. | 09-16-2010 |
| 20100233094 | PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME - The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields. | 09-16-2010 |
| 20100254911 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 10-07-2010 |
| 20100278748 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group. | 11-04-2010 |
| 20100278749 | NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING - Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group. | 11-04-2010 |
| 20100297025 | Novel compositions magnetic particles covered with gem-bisphosphonate derivatives - The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: | 11-25-2010 |
| 20100303730 | Methods of making iron-containing nanoparticles - A method of making iron-containing nanoparticles (e.g., magnetite nanoparticles) that includes contacting an iron-containing precursor with a reducing agent at a temperature less than 200° C. and allowing the mixture to react to form magnetite nanoparticles. | 12-02-2010 |
| 20110104072 | TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS - The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents. | 05-05-2011 |
| 20110104073 | Iron/Iron Oxide Nanoparticle and Use Thereof - The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are disclosed for use in hyperthermia treatment and imaging of cancer. | 05-05-2011 |
| 20110104074 | METHODS FOR TARGETED CANCER TREATMENT AND DETECTION - A method for treating a cancer is provided that comprises identifying a subject in need of treatment for a cancer and administering to the subject a composition that is comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor and a plurality of a chemotherapeutic agent, where each ligand and each chemotherapeutic agent are conjugated to a nanoparticle. Further provided are methods for detecting a cancer in a subject that comprise administering to a subject an imaging agent comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor conjugated to a nanoparticle. | 05-05-2011 |
| 20110110865 | CHELATROS, PARAMAGNETIC CHELATES THEREOF AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) - The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI). | 05-12-2011 |
| 20110135577 | Superparamagnetic nanoparticles IN MEDICAL THERAPEUTICS and manufacturing method THEREOF - The successful transfer of therapeutic agents such as genetic materials (e.g. nucleic acid) or drug into living cells is the most important issue depending on the development of the delivery carrier. A method for manufacturing superparamagnetic nanoparticles in medical therapeutics is described to develop nano-sized calcium phosphate (CaP) mineral was rendered magnetic as delivery vehicle. The CaP-based magnetized nanoparticles (NPs) were possessed superparamagnetic property by hetero-epitaxial growth of magnetite on the CaP crystallites and also showed no harm to the cultured cells and elicited no cytotoxicity. The magnetized CaP was demonstrated to have good plasmid DNA binding affinity or drug carrying capacity. It significantly increased the expression of gene transfection and efficiency in delivery to mesenchymal stem cells (MSCs) under exogenous magnetic field. According to the above facts, this newly-synthesized magnetized CaP NPs has great potential as a novel non-viral targeted delivery vehicle to be applied for medical applications. | 06-09-2011 |
| 20110158915 | NANOSHELLS WITH TARGETED ENHANCEMENT OF MAGNETIC AND OPTICAL IMAGING AND PHOTOTHERMAL THERAPEUTIC RESPONSE - A particle and a method of manufacturing a particle that includes a complex, a paramagnetic entity, and a silica layer that encapsulates the paramagnetic entity and the complex. The dielectric layer of the particle encapsulates the complex and the paramagnetic entity such that at least a portion of an outer surface of the complex is covered by the paramagnetic entity. In addition, the particle may or may not include a fluorescent entity encapsulated within the dielectric layer. Also, the particle may or may not include a targeting entity covalently bonded to the silica layer. | 06-30-2011 |
| 20110165086 | IRON OXIDE NANOPARTICLES AS MRI CONTRAST AGENTS AND THEIR PREPARING METHOD - Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T | 07-07-2011 |
| 20110195030 | NANOPARTICLE COMPOSITIONS COMPRISING LIQUID OIL CORES - Nanocapsule and nanoemulsion particle compositions having improved physical and pharmacological properties are provided. The nanocapsule or nanoemulsion particle composition can comprise a pharmaceutically acceptable liquid oil phase, a surfactant, and optionally a co-surfactant. The liquid oil phase can comprise a monoglyceride, a diglyceride, a triglyceride, a propylene glycol ester, or a propylene glycol diester. In certain embodiments, the nanocapsule or nanoemulsion particle composition can be lyophilized and subsequently re-hydrated without increasing the mean particle size and/or adversely affecting the potency or efficacy of a therapeutic agent (e.g., paclitaxel) present in the nanocapsules or nanoemulsion particles. | 08-11-2011 |
| 20110200533 | COMPOUNDS FOR THE DIAGNOSIS OF DISEASES ASSOCIATED WITH VCAM EXPRESSION - The present invention relates to a compound of the following general formula (I): | 08-18-2011 |
| 20110200534 | T1-T2 Dual Modal MRI Contrast Agents - The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost. In addition, the particle constituting the T1-T2 dual-modal contrast agent of the present invention may be applied to hyperthermia and drug delivery systems. | 08-18-2011 |
| 20110256066 | METHOD FOR PREPARING ENGINEERED MG DOPED FERRITE SUPERPARAMAGNETIC NANO PARTICLE EXHIBITING AC MAGNETIC INDUCTION HEATING AT HIGH TEMPERATURE AND MG DOPED FERRITE SUPERPARAMAGNETIC NANO PARTICLES ENGINEERED BY THE METHOD - The present invention relates to a method for preparing a ferrite superparamagnetic nano particle engineered by magnesium doping, and a technique for applying it to hyperthermia cancer cell treatment and the heat shock protein (HSP) self-defense mechanism. | 10-20-2011 |
| 20110274624 | CONTRAST AGENTS IN POROUS PARTICLES - MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed. | 11-10-2011 |
| 20120003160 | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session - Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage imaging agent to the subject during an administration session then allowing a passage of time sufficient for accumulation of the agent in macrophages of the subject. Subsequently, in a single imaging session, a macrophage-enhanced magnetic resonance image is acquired to target macrophages and a different magnetic resonance image is acquired to target physiological phenomenon other than macrophages. Additional embodiments provide methods wherein the acquisition of a different magnetic resonance image is achieved by vascular-enhanced MRI protocols or perfusion-enhanced MRI protocols, or combinations thereof. Further embodiments provide methods for utilizing acquired images in assessment of treatment of disease. | 01-05-2012 |
| 20120034169 | NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS - The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications. | 02-09-2012 |
| 20120058053 | CARBON NANOHORN MRI CONTRAST AGENTS - A contrast agent characterized in that each of carbon nanohorns forming a carbon nanohorn aggregate has an opening at the side wall or tip, wherein a metal M (at least one metal selected from among paramagnetic metals, ferromagnetic metals, and superparamagnetic metals) or a compound of the metal M is incorporated in or dispersed on each of the carbon nanohorns. A contrast agent characterized in that it contains a Gd oxide. There is provided a contrast agent, which can be mass-produced easily, and satisfies the requirement of low toxicity and enables microscopic diagnoses when used for MRI. A contrast agent characterized in that is contains a carbon nanohorn aggregate. | 03-08-2012 |
| 20120076737 | METHOD OF USING CT/MRI DUAL MODALITY CONTRAST AGENT - Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent. | 03-29-2012 |
| 20120087868 | NANOPARTICLE-LOADED CELLS - The invention provides nanoparticle-loaded cells and compositions useful for improved imaging and therapy, for example radio-therapy. The invention also provides methods of manufacture of nanoparticle-loaded cells, methods of administering the nanoparticle-loaded cells, and methods for treatment and/or imaging. | 04-12-2012 |
| 20120107246 | METHOTREXATE-MODIFIED NANOPARTICLES AND RELATED METHODS - Methotrexate-modified nanoparticles that target tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles. | 05-03-2012 |
| 20120156141 | NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF - A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging. | 06-21-2012 |
| 20120156142 | DIAGNOSTIC AGENT COMPOSITION AND ASSOCIATED METHODS THEREOF - A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion. | 06-21-2012 |
| 20120195835 | TUMOR TISSUE-SELECTIVE BIO-IMAGING NANOPARTICLES - A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle. | 08-02-2012 |
| 20120201759 | TUNABLE MULTISCALE STRUCTURES COMPRISING BRISTLY, HOLLOW METAL/METAL OXIDE PARTICLES, METHODS OF MAKING AND ARTICLES INCORPORATING THE STRUCTURES - Hierarchical nanostructures and methods of fabrication. The structures include particles having a metal oxide outer shell with metal oxide wires extending from the outer shell. A multiscale structure according to the invention has particles above and below a critical size wherein the particles above the critical size have wires extending from the surface. These structures may be fabricated from a mixture prepared of relatively smaller metal particles having a size threshold below a threshold for nanowire formation and of relatively larger metal particles having a size above the threshold for nanowire formation. The mixture is oxidized at a selected temperature and for a selected time whereby the relatively smaller particles sinter and nanowires grow on the relatively larger particles thereby creating tunable hierarchical structures with metal-to-metal contact between the particles. | 08-09-2012 |
| 20120219508 | CELLULOSE-BASED NANOPARTICLES FOR DRUG DELIVERY - In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided. | 08-30-2012 |
| 20130017155 | DUAL CT/MRI NANOPARTICLE CONTRAST AGENT - The invention relates to a new tungsten-iron-Ferritin nanoparticle and uses thereof in imaging. | 01-17-2013 |
| 20130052140 | FE3O4/TIO2 COMPOSITE NANO-PARTICLE, ITS PREPARATION AND APPLICATION IN MAGNETIC RESONANCE IMAGING CONTRAST AGENTS - This invention provides a Fe | 02-28-2013 |
| 20130108552 | NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME | 05-02-2013 |
| 20130115172 | MAGNETIC NANOPHOSPHOR HAVING CORE/SHELL STRUCTURE AND THE SYNTHETIC METHOD THEREOF - The present invention relates to a nanophosphor and method for synthesizing the same, and provides a nanophosphor containing fluoride-based nanoparticles co-doped with Yb | 05-09-2013 |
| 20130129632 | Quantum dot materials, methods for making them, and uses thereof - The disclosure provides quantum dot materials, compositions and methods useful in the treatment of various disorders. In particular, the disclosure provides cadmium-free and lead-free quantum dots. | 05-23-2013 |
| 20130129633 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 05-23-2013 |
| 20130164222 | Preparation of Extremely Small and Uniform Sized, Iron Oxide-Based Paramagnetic or Pseudo-Paramagnetic Nanoparticles and MRI T1 Contrast Agents Using the Same - Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles. | 06-27-2013 |
| 20130177503 | SHAPE-CONTROLLED MAGNETIC NANOPARTICLES AS T1 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING - Methods are provided for the generation of nanostructures suitable for use in magnetic resonance imaging where the nanostructures have at least one dimension of about 2 nm or less. In particular, the methods comprise the selective use of incubation temperatures that result in the controlled removal of ligands from metallic cores to which they are attached, allowing the metallic cores or the precursor moieties to unite to form nanostructures of defined and predictable shapes, but having at least one dimension significantly less that at least one other dimension. Accordingly, the nanostructures of the disclosure may be ultrathin sheets, rods, whiskers and the like, or even structures that are thin and porous resembling rice grains. The temperatures useful in the methods of the disclosure are less than 300° C. and allow for progressive elevation of the incubation temperature. The methods are especially advantageous for synthesizing nanoparticles that may be administered to an animal or human subject for imaging with magnetic resonance. Accordingly, the nanostructures of the disclosure comprise a metallic core, most typically, but not necessarily limited to, a ferrite moiety that can be a ferrous or ferric ion alone or in combination with other metallic elements. However, the methods of the disclosure are also suitable for generating nanostructures with non-ferrous cores such as magnesium or manganese cores. | 07-11-2013 |
| 20130224122 | MAGNETOTATIC BACTERIA MRI POSITIVE CONTRACT ENHANCEMENT AGENT AND METHODS OF USE - Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. | 08-29-2013 |
| 20130243699 | Biodegradable Magnetic Nanoparticles and Related Methods - The design of biodegradable magnetic nanoparticles for use in in-vivo biomedical applications. The particles can include Fe in combination with one or more of Mg, Zn, Si, C, N, and P atoms or other particles. The nanoparticles can be degraded in-vivo after usage. The nanoparticles can cease heating upon reaching a predetermined temperature or other value. | 09-19-2013 |
| 20130251641 | Functionalized Magnetic Nanoparticles and Methods of Use Thereof - The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided. | 09-26-2013 |
| 20130287703 | CORE/SHELL MULTIFUNCTIONAL MAGNETIC NANOPHOSPHOR HAVING CORE/SHELL STRUCTURE AND SYNTHETIC METHOD THEREOF - The present invention relates to a nanophosphor and a synthesis method thereof, and provides a nanophosphor comprising a first compound of Formula 1, wherein the first compound is fluoride-based one which is co-doped with Ce | 10-31-2013 |
| 20130309176 | CHELATE NANOEMULSION FOR MRI - The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising:
| 11-21-2013 |
| 20130315838 | BIOMATERIALS SUITABLE FOR USE AS DRUG ELUTING, MAGNETIC RESONANCE IMAGING DETECTABLE IMPLANTS FOR VASCULAR OCCLUSION - Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided. | 11-28-2013 |
| 20130315839 | IRON OXIDE NANOPARTICLES AS MRI CONTRAST AGENTS AND THEIR PREPARING METHOD - Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T | 11-28-2013 |
| 20130330279 | NANOPARTICLE MEDIATED GENE THERAPY, DIAGNOSTIC PRODUCTS AND THERAPEUTIC PRODUCTS FOR BREAST CANCER - The present disclosure provides compositions and methods of treating Breast Cancer. Disclosed is a nanoparticle paired to at least one of W genetic materials that suppress key regulators of fat synthesis (e.g. Rev-erb) to cause a predefined target cell types apoptosis or X predefined targeting moieties that cause predefined target cell types apoptosis and correspond to Y predefined target parameters associated with Z predefined target cell types in connection with treatment of at least one of the following breast cancer, glioblastoma, head and neck cancer, pancreatic cancer, lung cancer, cancer of the nervous system, gastrointestinal cancer, prostate cancer, ovarian cancer, kidney cancer, retina, cancer, skin cancer, liver cancer, genital. | 12-12-2013 |
| 20140050668 | VISUALIZATION OF LIPID METABOLISM - The present invention relates to the field of in vivo determination of enzyme activity. It also allows visualization of organisms, organs, tissues and cells. In particular, the present invention provides a method of in vivo visualization and a composition suitable for in vivo determination and/or visualization of enzyme activity by methods such as Magnetic Resonance Imaging, also called Magnetic Resonance Tomography (MRI or MRT), or Magnetic Particle Imaging (MPI). In particular, the activity of the enzyme lipoprotein lipase affects the signals received and allows conclusions on the lipid metabolism of an organism, an organ system, an organ, a tissue and a cell of interest, This method can be employed, e.g., for diagnosis of cardiac disorders, of tumor prognosis and of disorders of the lipid metabolism. The composition used comprises superparamagnetic iron oxide nanocrystals (SPIO) incorporated in the core of lipid micelles designated nanosomes. | 02-20-2014 |
| 20140056819 | NANOPARTICULATE COMPOSITIONS FOR DIAGNOSTIC IMAGING - The present invention provides a trialkoxysilanes having structure I | 02-27-2014 |
| 20140140932 | Functionalized Magnetic Nanoparticles and Use in Imaging Amyloid Deposits and Neurofibrillary Tangles - The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles. | 05-22-2014 |
| 20140161730 | MAGNETIC GRAPHENE-LIKE NANOPARTICLES OR GRAPHITIC NANO- OR MICROPARTICLES AND METHOD OF PRODUCTION AND USES THEREOF - A magnetic graphene-like nanoparticle or graphitic nano- or microparticle exhibits a high relaxivity, and is useful as a MRI contrast agent. A composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. Methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. Methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle. | 06-12-2014 |
| 20140170075 | NON-INVASIVE IMAGING METHODS FOR PATIENT SELECTION FOR TREATMENT WITH NANOPARTICULATE THERAPEUTIC AGENTS - Methods for providing treatment of pathologic conditions with nanoparticulate therapeutic agents are disclosed. Novel methods for determining liposomal deposition at sites of pathology using non-invasive imaging are also disclosed. | 06-19-2014 |
| 20140294734 | Magnetic Resonance Imaging (MRI) Based Quantitative Kidney Perfusion Analysis - Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance renography (MRR). Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a kidney. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the kidney from a signal intensity in the data based, at least in part, on a two compartment model of the kidney. The two compartment model includes a plasma compartment and a tubular compartment. The quantized value describes a perfusion parameter for the kidney or a filtration parameter for the kidney. Greater precision is achieved for estimates of the perfusion parameter or filtration parameter as a result of the quantization performed on data acquired with greater spatial resolution and temporal resolution. | 10-02-2014 |
| 20140308213 | COLOR TUNABLE MULTIFUNCTIONAL NANOPHOSPHOR, SYNTHESIS METHOD THEREOF, AND POLYMER COMPOSITE INCLUDING THE NANOPHOSPHOR - A nanophosphor in accordance with one exemplary embodiment of the present disclosure includes a fluoride-based nanoparticle co-doped with Ce | 10-16-2014 |
| 20140328765 | T1-T2 DUAL MODAL MRI CONTRAST AGENTS - The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost. In addition, the particle constituting the T1-T2 dual-modal contrast agent of the present invention may be applied to hyperthermia and drug delivery systems. | 11-06-2014 |
| 20140335025 | TARGETING CORROLES FOR TUMOR TOXICITY AND MRI - Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject. | 11-13-2014 |
| 20140348755 | TARGETED NANOPARTICLES JOINED TO REPORTER MOLECULES THROUGH MULTIPLE MECHANISMS - Nanoparticles, such as liposomes etc., containing multiple reporter molecules, e.g. dyes, fluorophores, FRET pairs, semiconductor nanocrystals, fluorescent chelates, chelate complexes, coordination complexes, mass tags, Raman tags, lanthanides, enzymes, enzymatic substrates, etc., through a combination of multiple physical and/or chemical interactions are disclosed. The reporter molecules are associated with the nanoparticle in at least two different ways, i.e. through different mechanisms. The nanoparticle is targeted through a targeting agent such as an antibody, an antibody fragment, a nucleotide, a peptide, an aptamer, biotin, avidin, or a ligand. The nanoparticles are useful in bioassays or imaging where an analyte is to be detected by binding of the nanoparticle to the analyte and detection of a signal from the reporter molecules. | 11-27-2014 |
| 20140369937 | ACTIVATABLE NANOPROBES FOR INTRACELLULAR DRUG DELIVERY - An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound. | 12-18-2014 |
| 20140369938 | CURCUMIN COATED MAGNETITE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS - The present invention discloses biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles (USPION) for biomedical applications. Disclosed herein is also a simple one-pot process for the synthesis of biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles in absence of a linker or binder. The curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles of the present invention retains the medicinal, radical scavenging and fluorescence properties of curcumin. | 12-18-2014 |
| 20150010476 | Rare Earth Oxide Particles and Use Thereof in Particular Imaging - The present application concerns multimodal composite products for imaging, in particular for diagnostic imaging, and optionally for therapy, in particular composite products which are capable of being used as contrast agents, in particular in magnetic resonance imaging (MRI), and/or in imaging techniques such as, for example, in optical imaging, in the optical detection of oxidants, in positron emission tomography (PET), in tomodensitometry (TDM) and/or in ultrasound imaging, and optionally simultaneously for use in therapy. These products are based on a particle comprising or consisting of a portion provided with a contrast agent activity and/or a paramagnetic activity, and a portion provided with a luminescent activity and optionally an oxidant detection activity. | 01-08-2015 |
| 20150017102 | COBALT-BASED MRI CONTRAST AGENT AND IMAGING SYSTEM - Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices. | 01-15-2015 |
| 20150056144 | ENCAPSULATED DIAGNOSTICS AND THERAPEUTICS IN NANOPARTICLES - CONJUGATED TO TROPIC CELLS AND METHODS FOR THEIR USE - A therapeutic or diagnostic delivery vehicle is provided. The delivery vehicle may include one or more particles, such as microparticles, nanoparticles and stimuli-responsive particles, conjugated to a tropic cell that targets at least one pathological entity or site. In addition, a pharmaceutical composition is provided. The pharmaceutical composition may include, among other things, a particle conjugated to a tropic cell such as those discussed above and at least one diagnostic or therapeutic agent, such as those described herein. In some aspects, the tropic cell may target at least one pathological entity or site. Further, methods for diagnosing, monitoring or treating a pathological condition in a subject are provided. Such methods may include administering a therapeutically effective amount of the pharmaceutical composition to a subject. | 02-26-2015 |
| 20150056145 | MAGNETIC NANOPARTICLE-SAMIRNA COMPLEX AND METHOD FOR PREPARING SAME - Provided are a SAMiRNA-magnetic nanoparticle complex capable of effectively delivering a double-stranded oligo RNA and magnetic nanoparticles into a cell and a composition capable of simultaneously performing diagnosis and therapy of diseases such as cancer, and the like, containing the same. More specifically, provided is the SAMiRNA-magnetic nanoparticle complex consisting of double-stranded oligo RNA-polymer structures in which a hydrophilic material and a second hydrophobic material are bound to the double-stranded oligo RNA by a simple covalent bond or a linker-mediated covalent bond, and the magnetic nanoparticles in which a first hydrophobic material is bound onto a surface of the magnetic material, as a core. | 02-26-2015 |
| 20150125398 | MULTIMODAL IMAGING METHODS USING MESOPOROUS SILICA NANOPARTICLES - The invention provides particles useful for sequential imaging or for diagnostics or therapeutics. Disclosed is a method to image diagnostic or therapeutic cells in a mammal, comprising: introducing to a mammal a composition comprising mammalian cells comprising mesoporous silica nanoparticles (MSNs) comprising a lanthanide, a fluorophore and an agent detectable by ultrasound; applying ultrasound and/or a magnetic field to the mammal and recording ultrasound and/or magnetic resonance images that include the MSNs; and detecting the presence, location or amount of the MSNs in the mammal. | 05-07-2015 |
| 20150335767 | Dual-Mode Contrast Agent and Uses Thereof in Real-time Monitoring and Harvesting of Neural Stem Cells - A real-time method to monitor and harvest stem cells is provided in the present invention. In particular, the present invention provides a real-time method to monitor and harvest neural stem cells. The present invention has applications in providing an individualized cell replacement therapy for patient in need thereof. More specifically, the present invention has applications in performing real-time monitoring and harvesting of neural stem cells using magnetic resonance imaging (MRI). | 11-26-2015 |
| 20150352231 | MAGNETIC NANOPARTICLE COMPOSITION AND MANUFACTURING METHOD AND USE THEREOF - The present invention provides a magnetic nanoparticle composition, comprising an iron oxide particle core conjugated with a capping agent and having wüstite structure and antiferromagnetic properties, wherein the empirical formula of iron oxide is defined as Fe | 12-10-2015 |
| 20150359910 | TARGETING APTAMER FOR ATHEROSCLEROSIS AND PREPARATION METHOD AND APPLICATION THEREOF - Disclosed are a targeting aptamer for atherosclerosis and a preparation method and application thereof. The targeting aptamer is a targeting aptamer fragment for atherosclerosis obtained through screening of macrophage-derived foam cells together with reverse screening of smooth muscle cells, endothelial cells, and THP-1 cells using a SELEX method; and the use of the targeting aptamer in preparation of an MRI targeting nano-contrast agent for atherosclerosis allows the specific binding of the MRI targeting nano-contrast agent for atherosclerosis only with the macrophage-derived foam cells, and allows high specific binding thereof with vascular tissues with AS lesion, this improving targeting effect of the MRI targeting nano-contrast agent for atherosclerosis and realizing early specific diagnosis of arterial sclerosis. | 12-17-2015 |
| 20160008490 | METAL CHELATE COMPOUNDS FOR BINDING TO THE PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA | 01-14-2016 |
| 20160038610 | COMPOSITIONS AND METHODS FOR IMAGING AND TREATMENT - Provided are compositions and methods for transport, monitoring the transport, and controlled release of active agents. The compositions comprise surface functionalized iron oxide nanoparticles. The iron oxide nanoparticles are surface functionalized with cucurbitril[7] macrocycles. The cavity formed by the CB[7] macrocycles can be used for storage and transport of active agents. The active agents may be imaging agents or may be therapeutic agents which can be released by applying an alternating magnetic field at desired locations. | 02-11-2016 |
| 20160038618 | PLASMONIC SUB-100 NM NANOMATRYOSHKAS THAT CONFINE CONTRAST AGENTS WITHIN LAYERS OF METAL - A magnetic resonance imaging enhancement agent includes a plurality of particles. Each particle including a metal core; a dielectric shell disposed on the metal core including water and at least one MRI contrast agent; and a metal shell disposed on the exterior surface of the dielectric shell that encapsulates the dielectric shell. | 02-11-2016 |
| 20160045623 | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) - The invention provides systems and methods for providing a diagnostic examination to a patient, including, but not limited to a determination of the permeability of a patients' body cavity. | 02-18-2016 |
| 20160045624 | COATED PLANT VIRUS IMAGING AGENTS - An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed. | 02-18-2016 |
| 20160051708 | Metal Oxide Nanoparticle-Based Magnetic Resonance Imaging Contrast Agent with a Central Cavity - The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly an MRI contrast agent derived from nanoparticle that is porous first metal-doped second metal oxide nanoparticle with a central cavity, and a method for producing the same. The MRI contrast agent made in accordance with the present invention can be used not only as a drug-delivery agent for therapy but also as an MRI contrast agent for diagnosis. | 02-25-2016 |
| 20160058892 | PREPARATION OF BONE-SEEKING SUPERPARAMAGNETIC IRON NANOPARTICLES AS CONTRAST AGENTS AND METHODS FOR USING THE SAME - Described herein are compositions having a nanoparticle that is conjugated to at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the nanoparticle by a linker, wherein the nanoparticle contains iron, and wherein the compositions are neutral or pharmaceutically acceptable salts or esters. Also described herein are methods of making these compositions. In one aspect, the nanoparticles serve as contrast agents for magnetic resonance imaging of bone metabolism. The compounds, compositions, and methods described herein can be used in a number of therapeutic applications including diagnosing or monitoring fracture and/or the progress of conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteopenia, and hypercalcemia. | 03-03-2016 |
| 20160074538 | NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING APPLICATIONS - A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging. | 03-17-2016 |
| 20160089436 | SELF-ASSEMBLED PHARMACEUTICAL COMPOSITION FOR PHOTODYNAMIC THERAPY - The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same. | 03-31-2016 |
| 20160129138 | OCTAPOD IRON OXIDE NANOPARTICLES AS HIGH PERFORMANCE T2 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING - Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles. | 05-12-2016 |
| 20160158155 | MAGNETIC NANOPARTICLES USEFUL FOR MAGNETIC SENSOR DETECTION ESPECIALLY IN BIOSENSOR APPLICATIONS - Disclosed is process for preparing magnetic nanoparticles (MNPs) that results in very sensitive MNPs that can be used in a variety of diagnostic and analytical methods. The MNPs exhibit superparamagnetism and find special use in giant magnetoresistance sensors (GMRS). The MNPs are created by a process that permits one to tune the size of nanoparticles to a range of from 10 to 20 nanometers with a very small particle size distribution of +/−2 nanometers or less. The MNPs can be tagged with a variety of markers and thus find use in many analytical assays, cell sorting techniques, imaging methods, drug delivery methods and cancer treatments. The inventive MNPs can be detected in magnetic file strengths of 2000 Oe or less. | 06-09-2016 |
| 20160160207 | PROBIOTIC BACTERIA COMPRISING METALS, METAL NANOPARTICLES AND USES THEREOF - The invention relates to probiotic bacteria selected from lactic acid bacteria, such as Lactobacillus and Bifidobacteria, having metals and/or metal nanoparticles and to foodstuff and pharmaceutical composition having these bacteria. The invention also provides methods for obtaining these bacteria and uses of these bacteria for the treatment and prevention of mineral deficiency pathologies, as a contrast agent for the imaging of the digestive tract and for the treatment of cancer. | 06-09-2016 |
| 20160184461 | FUNCTIONALIZED MAGNETIC NANOPARTICLES AND USE IN IMAGING AMYLOID DEPOSITS AND NEUROFIBRILLARY TANGLES - The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles. | 06-30-2016 |
| 20160250331 | Biodegradable Magnetic Nanoparticles and Related Methods | 09-01-2016 |
| 20160375154 | Gd(III)-Dithiolane Gold Nanoparticle Conjugates - Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue. | 12-29-2016 |
| 20160376319 | COLLAGEN IMAGING COMPOSTIONS - Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides. | 12-29-2016 |
