Entries |
Document | Title | Date |
20080212868 | Process for Segmenting Leukocytes - A method for segmenting stained leukocytes in blood smears includes the following steps: the pixels of the digital images taken of the blood smears are allocated to one of at least three pixel classes according to their chromaticity values; the chromaticity values of all pixels of the image are subjected to the same transformation with which the pixels allocated to the class of the image background appear at least almost white; a transformation of the stained image obtained takes place into an alternative color space, which represents the hue, color saturation and color intensity separately, and hue, color saturation and color intensity of all pixels are ascertained; a probability value is calculated for each pixel for its association to a leukocyte, the probability value corresponding to the product of the probability value for the hue of the leukocyte nucleus with at least one further probability value; then these probability values are defined with reference to previously ascertained and defined associations, and the pixels with a high value of the product of the probability values are considered as belonging to a leukocyte. | 09-04-2008 |
20080317326 | Method For Ensuring Quality of a Sample Carrier - A method is provided for ensuring the quality of a sample carrier in connection with performing an analysis of a sample in the sample carrier in an analysis instrument for in vitro diagnosis, wherein the sample carrier is provided with a symbol for confirming the compatibility of the sample carrier with the analysis instrument. The method comprises bringing the sample carrier to an imaging position in the analysis instrument, acquiring an image of the sample carrier, and analysing the acquired image to detect the presence of a symbol for identifying the genuineness of the sample carrier. Where the sample carrier is identified as genuine, the sample carrier is approved for use in the analysis instrument and the analysis instrument is enabled to perform an analysis of the sample in the sample carrier. The analysis comprises irradiating the sample by transmitting electromagnetic radiation through the sample carrier. | 12-25-2008 |
20090003681 | BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER - Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected. | 01-01-2009 |
20090041329 | Network Review in Clinical Hematology - Embodiments of the invention provide techniques for using digital imaging and networked communications in clinical hematology. An Area of Interest (AOI) on a slide is determined. A high resolution image of the AOI is analyzed for sample integrity and adjusted and rescanned based on programmable parameters. Sensitive HIPAA information is removed from the AOI image stored on a server. The server includes Web 2.0 software applications. A remote user reviews the image and adds metadata to the server. The server manages the work flow between the stored AOI images and the available users. A technician accesses information about a particular image file, as well as other topics, through knowledge management and social network applications. Lab reports are generated based on the metadata. The quality of the metadata is subject to quality control processes. The stored images and associated metadata can be mined for subsequent medical research. | 02-12-2009 |
20090080757 | DETECTING ACCESS DISCONNECT BY PATTERN RECOGNITION - A blood detection system is used to detect blood in a patient undergoing an extracorporeal blood therapy, such as hemodialysis or apheresis. The blood detection system uses a digital video device, which may be a camera, such as a standard digital video camera, a low light camera, an infrared camera, or a night vision camera. The digital image is sent to a computer with image processing and pattern recognition software. The software is used to detect whether a pool of blood is forming at the access site. The system is able to detect a pool of blood atop the access site, such as when a leak or a dislodgement of a needle occurs. The system is also able to detect pooling of blood under the skin, as a result, for instance, infiltration of an arteriovenous fistula. | 03-26-2009 |
20090123054 | DETECTION OF CIRCULATING TUMOR CELLS IN PERIPHERAL BLOOD WITH AN AUTOMATED SCANNING FLUORESCENCE MICROSCOPE - An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids. | 05-14-2009 |
20090129661 | SYSTEMS, METHODS AND APPARATUS FOR PLAQUE VISUALIZATION AND QUANTIFICATION USING FUZZY AND ADAPTIVE REGION CLASSES - Systems, methods and apparatus are provided through which carotid plaque is classified in an image and visually displayed using an iterative adaptive process, such as an expectation maximization process. | 05-21-2009 |
20090148024 | System and Method for Blood Vessel Bifurcation Detection in Thoracic CT Scans - A method for detecting blood vessel bifurcations in digital medical images includes inflating a sphere from a first center point inside a segmented blood vessel until a surface of the sphere intersects a surface of the blood vessel, searching within the inflated sphere for a second center point that has a sphere intersecting a surface of the blood with a maximum radius, assigning all voxels of the maximal radius sphere to a root node of a shape-tree, increasing the radius of the maximal radius sphere and computing a voxel difference set with respect to the previous maximal radius sphere, computing one or more connected components C | 06-11-2009 |
20090190822 | BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER - Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected. | 07-30-2009 |
20090220141 | IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND IMAGE PROCESSING PROGRAM - A blood vessel imaging device obtains peak height information of a differential function F′(x) from an adjustment dial. The blood vessel imaging device, based on the peak height information and peak position information of the differential function F′(x), then defines the differential function F′(x). Subsequently, the blood vessel imaging device calculates an LUT function F(x) that indicates the shape of an LUT by integrating the defined differential function F′(x). The blood vessel imaging device generates an LUT based on the LUT function F(x). The blood vessel imaging device reads out a picked-up image stored in a picked-up image memory, converts a luminance value of the picked-up image being read using the LUT, and displays the image with the converted luminance value. | 09-03-2009 |
20090238437 | METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS - A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values. | 09-24-2009 |
20090238438 | METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS - A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided. | 09-24-2009 |
20090238439 | METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS - A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample. | 09-24-2009 |
20090252399 | SELF-CALIBRATING GRADIENT DILUTION IN A CONSTITUENT ASSAY AND GRADIENT DILUTION APPARATUS PERFORMED IN A THIN FILM SAMPLE - A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to use the same principles to provide a wide range of sample dilutions within the chamber so as to obviate the need for additional dilution steps when dealing with samples possibly containing wide ranges of analyte concentrations. | 10-08-2009 |
20090324052 | DETECTION AND LOCALIZATION OF VASCULAR OCCLUSION FROM ANGIOGRAPHY DATA - A technique for detecting and localising vascular occlusions in the brain of a patient is presented. The technique uses volumetric angiographic data of the brain. A mid-sagittal plane and/or lines is/are identified within the set of angiographic data. Optionally, the asymmetry of the hemispheres is measured, thereby obtaining an initial indication of whether an occlusion might be present. The angiographic data is mapped to pre-existing atlas of blood supply territories, thereby obtaining the portion of the angiographic data corresponding to each of the blood supply territories. For each territory (including any sub-territories), the asymmetry of the corresponding portion of the angiographic data about the mid-sagittal plane/lines is measured, thereby detecting any of the blood supply territory including an occlusion. The angiographic data for any such territory is displayed by a three-dimensional imaging technique. | 12-31-2009 |
20100021039 | BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER - Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected. | 01-28-2010 |
20100027868 | Blood sample analyzing apparatus, blood sample coagulation determining apparatus, blood sample coagulation determining method and computer program product - The present invention is to present a blood sample analyzing apparatus, comprising: an aspirator for aspirating a blood sample to be used for measurement; a coagulation determiner for determining whether the blood sample is coagulated or not; and an aspirating controller for controlling an operation of the aspirator based on a determination result by the coagulation determiner. | 02-04-2010 |
20100054575 | Analysis method for 5-differential complete blood cell based on visual image - An analysis method for five-differential complete blood cell based on visual image is provided. The analysis method for five-differential complete blood cell is carried out in two channels. The method includes: counting blood cells by typical cytometry to obtain the amount of blood cells; identifying and counting the blood cells by image recognition to obtain the percent of each kind of blood cells; then calculating the results from the two channels to obtain the number of each kind of blood cells. | 03-04-2010 |
20100054576 | IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND IMAGE PROCESSING PROGRAM - The image quality of fluorescent images of blood vessels obtained by imaging blood vessels emitting fluorescence is improved. Living tissue within a body cavity is imaged by an endoscope while fluorescent pigments within blood vessels are emitting fluorescence due to irradiation of excitation light. At this time, a standard observation image obtained by imaging the same portion of the body cavity while white light is being irradiated, and a fluorescent image obtained by imaging while the excitation light is being irradiated are obtained. A plurality of spectral images having different wavelength ranges are generated. The depth position of blood vessels within a region of interest are judged by a depth position judging unit. Thereafter, an image processing unit administers an image process using image processing conditions corresponding to the depth position of the blood vessels, and a processed image is displayed by a display device. | 03-04-2010 |
20100104168 | MEASUREMENT OF FUNCTIONAL MICROCIRCULATORY GEOMETRY AND VELOCITY DISTRIBUTIONS USING AUTOMATED IMAGE ANALYSIS - The invention provides analysis algorithms for quantitative assessment of microvasculatory video sequences that provide vessel thickness, vessel length and blood velocity per vessel segment. It further provides a method of for calculating the functional microvasculatory density and blood velocity as distributed over vessels with different thickness, in the field of view. | 04-29-2010 |
20100104169 | SPECIMEN PROCESSING SYSTEM AND BLOOD CELL IMAGE CLASSIFYING APPARATUS - A specimen processing system comprising: a blood cell counting apparatus; and a blood cell image classifying apparatus, wherein the blood cell image classifying apparatus comprises a controller to carry out operations, comprising: receiving a plurality of first count results of a predetermined type of the blood cell by the blood cell counting apparatus; obtaining a plurality of second count results of the predetermined type of the blood cell on the basis of the blood cell image; storing the plurality of the first count results and the second count results; reading at least one of the first count results, and at least one of the second count results obtained from a blood specimen corresponding to the first count result; generating and outputting a quality control screen on the basis of the read first count result and the read second count result. A blood cell image classifying apparatus is also disclosed. | 04-29-2010 |
20100128963 | IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD - A storage unit stores volume data including a blood vessel region. An extracting unit extracts the blood vessel region from the volume data. A specifying unit specifies a position of a region of interest in the blood vessel region and a deflection direction of a blood vessel region included in the region of interest. A determining unit determines a viewing position and a viewing direction based on the position of the region of interest and the deflection direction. A generating unit generates image data concerning the viewing position and the viewing direction based on the volume data. A display unit displays an image represented by the image data. | 05-27-2010 |
20100158342 | Image matching method, program, and image matching system - An image matching method capable of matching images with a high precision and a program and an image matching system for the same, providing a conversion unit for performing image processing based on a registered image and a match image for converting points in each image to patterns of curves based on a distance from a reference position to the closest point on a straight line passing through each point in the image from the reference position and an angle formed by a straight line passing through the reference position and the closest point and an x-axis as a reference axis including the reference position, converting linear components in the images to patterns of a plurality of overlapped curves, and generating converted images, a correlation value generation unit for performing correlation processing based on the converted images and generating a correlation value, and a matching unit for performing the matching based on a signal indicating the correlation value generated by the correlation value generation unit. | 06-24-2010 |
20100183216 | CELL IMAGE PROCESSING APPARATUS, CELL IMAGE PROCESSING METHOD AND COMPUTER PROGRAM PRODUCT - The present invention is to present a cell image processing apparatus comprising: an imaging unit for imaging a specimen smeared on a slide glass, and obtaining a cell image of a cell included in the smeared specimen; a display; and a processing unit being configured to perform operations comprising: obtaining a plurality of characteristic values based on a plurality of cell images obtained by the imaging unit, each of the plurality of characteristic values respectively representing a predetermined characteristic of each of the plurality of cell images; and controlling the display so as to display a screen showing a fluctuation in the obtained characteristic values. | 07-22-2010 |
20100220916 | AUTOMATED PLACENTAL MEASUREMENT - A method for analyzing the placenta in two or three dimensions comprising: selecting one or more placental samples to be analyzed; obtaining a digital image of each placental sample; and performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital image. The results of the analysis are correlated with data on health outcomes in infants, children, or adults and are used to assess future health risks to a patient. | 09-02-2010 |
20100220917 | AUTOMATIC GENERATION OF A VASCULAR SKELETON - Apparatus and methods are described for receiving into at least one processor at least one image of blood vessels of a subject. Using image processing, discontinuous lines that correspond to paths of at least a portion of the blood vessels in the image are automatically derived, the lines having end points at discontinuities in the lines. Continuous lines that correspond to the paths of the portion of the blood vessels in the image are automatically generated by bridging the discontinuities in the discontinuous lines. An output is generated by the processor, based on the continuous lines. Other embodiments are also described. | 09-02-2010 |
20100226558 | Registering Device, Checking Device, Program, and Data Structure - A registering device, a collating device, and a program which are capable of improving authentication accuracy and a data configuration of identification data capable of improving reliability are proposed. Parameters representing shapes of partial lines obtained by dividing a blood vessel line appearing in an image by setting end points and branch points of the blood vessel line as reference points are extracted and data including the parameters of the partial lines and positions of points of opposite ends of the partial lines is generated as data identifying a live body. | 09-09-2010 |
20100232675 | BLOOD AND CELL ANALYSIS USING AN IMAGING FLOW CYTOMETER - Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained. | 09-16-2010 |
20100272345 | METHOD FOR PERFORMING COUNTS WITHIN A BIOLOGIC FLUID SAMPLE - A method for enumerating cellular elements and particulates within a biologic fluid sample is provided. According to one aspect of the invention, the method includes the steps of: a) providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height, and which chamber has a known volume; b) introducing the biologic fluid sample into the chamber in an amount such that the sample extends between the first and second members for substantially the entire extent of the chamber, which fluid sample has first cellular elements having a first thickness and second cellular elements having a second thickness; c) selecting the chamber height relative to the first and second thicknesses such that the first and second cellular elements non-uniformly distribute within the sample upon introduction into the chamber; d) examining substantially all of the sample within the chamber and enumerating all of at least one of the elements; and e) determining a number per unit volume of sample of the at least one of the elements. | 10-28-2010 |
20100284602 | METHOD FOR DETERMINING A COMPLETE BLOOD COUNT ON A WHITE BLOOD CELL DIFFERENTIAL COUNT - Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device. | 11-11-2010 |
20100290693 | LOCATION-SENSITIVE CURSOR CONTROL AND ITS USE FOR VESSEL ANALYSIS - Apparatus and methods are provided, including displaying an image of one or more lumens of a subject. A processor includes lumen-identification functionality configured to automatically identify one or more lumens in the image. Envelope-designation functionality of the processor designates as lumen envelopes, portions of the image in vicinities of respective lumens. In response to the user designating a location inside a lumen envelope of a given lumen, via an input device, the location corresponding to a given longitudinal location within the given lumen, feature-generation functionality of the processor generates a feature on the image that corresponds to the given longitudinal location. An output is displayed in response to the generated feature. Other embodiments are also described. | 11-18-2010 |
20100303331 | SPECIMEN PROCESSING APPARATUS AND SPECIMEN PROCESSING METHOD - According to an example of the invention, a specimen processing apparatus includes, image detection unit for detecting image data on a specimen before an analytical process to analyze the specimen, and chyle-laky blood detection unit for detecting a chylous or laky state of the specimen by the color of the specimen, based on the detected image data. | 12-02-2010 |
20110002526 | Method and Apparatus for Counting Thrombocytes - A method of counting thrombocytes contained in a sample of blood, the method having the steps:
| 01-06-2011 |
20110033102 | System and Method for Coronary Digital Subtraction Angiography - A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image. | 02-10-2011 |
20110038524 | BLOOD AGGREGATION ABILITY MEASURING APPARATUS - To quantify the aggregation ability of various types of blood cells respectively within a short period of time. An apparatus for achieving the above-described object, which includes: a TV camera for taking an image of blood flow; an image processing section for identifying the types of blood cells contained in a blood cell retention part, in which blood cells are retained, from a blood flow image taken by the TV camera; and an aggregation ability calculation device for calculating at least one of the area, cell count and position of blood cells of each type as the aggregation ability of blood. | 02-17-2011 |
20110069876 | IMAGE PROCESSING APPARATUS, IMAGE PROCESSING PROGRAM RECORDING MEDIUM, AND IMAGE PROCESSING METHOD - An image processing apparatus includes: a category area dividing unit that divides each image constituting the time-series images of an object to be examined, which are captured in time series, into category areas including an examined area and an abnormal candidate area, the examined area showing the object to be examined, the abnormal candidate area being possibly an abnormal area showing an abnormal site of the object to be examined; an optical flow calculator that calculates optical flows of the examined area and the abnormal candidate area from images constituting the time-series images; and an abnormal area detector that compares the optical flow of the examined area and the optical flow of the abnormal candidate area, and detects the abnormal candidate area as the abnormal area according to the result of the comparison. | 03-24-2011 |
20110123090 | METHOD AND DEVICE FOR DETERMINING A CONTOUR AND A CENTER OF AN OBJECT - A method for determining a contour of an object in a digital image includes determining a preliminary object center and determining contour candidate image points. The contour candidate image points are determined as image points on a plurality of paths leading away from a preliminary object center by detecting a change from a first section to a second section on a feature space based on the image point value range of the digital image or by detecting the exceeding of a predetermined strength of a feature change in the feature space, wherein the contour candidate image points have a distance to the preliminary or to an improved object center and are ordered according to a polar angle. Further, the method includes determining zones of neighboring contour candidate image points within which a change of the distance of the contour candidate image points lies above a threshold value and an elimination of contour candidate image points which lie between the zones of neighboring contour candidate image points. Finally, a determination of the contour is executed on the basis of the remaining contour candidate image points. | 05-26-2011 |
20110164803 | METHOD AND APPARATUS FOR DETERMINING MEAN CELL VOLUME OF RED BLOOD CELLS - A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius. | 07-07-2011 |
20110170760 | Network Image Review In Clinical Hematology - Embodiments of the invention provide techniques for using digital imaging and networked communications in clinical hematology. An Area of Interest (AOI) on a slide is determined. A high resolution image of the AOI is analyzed for sample integrity and adjusted and rescanned based on programmable parameters. Sensitive HIPAA information is removed from the AOI image stored on a server. The server includes Web 2.0 software applications. A remote user reviews the image and adds metadata to the server. The server manages the work flow between the stored AOI images and the available users. A technician accesses information about a particular image file, as well as other topics, through knowledge management and social network applications. Lab reports are generated based on the metadata. The quality of the metadata is subject to quality control processes. The stored images and associated metadata can be mined for subsequent medical research. | 07-14-2011 |
20110206264 | IMAGE ANALYSIS SYSTEM AND/OR METHOD - Among other things, a method is disclosed comprising: receiving image data representing an image; processing the data to generate orientation information; processing the data using the orientation information to measure a quantity called local phase in a direction perpendicular to the orientation of a putative vessel; using the phase measurements from three collinear image locations or from two locations to detect the centerline of a symmetric image structure, such as a blood vessel, and to locate a center-point defined by the intersection of the centerline with the line created by the measurement locations. | 08-25-2011 |
20110211745 | SYSTEMS AND METHODS FOR IMAGE SEGMENTATION WITH A MULTI-STAGE CLASSIFIER - The systems and methods described herein provide for fast and accurate image segmentation through the application of a multi-stage classifier to an image data set. An image processing system is provided having a processor configured to apply a multi-stage classifier to the image data set to identify a distinctive region. The multi-stage classifier can include two or more component classifiers. The first component classifier can have a sensitivity level configured to identify one or more target regions in the image data set and the second component classifier can have a specificity level configured to confirm the presence of the distinctive region in any identified target regions. Also provided is a classification array having multiple multi-stage classifiers for identification and confirmation of more than one distinctive region or for the application of different classification configurations to the image data set to identify a specific distinctive region. | 09-01-2011 |
20110235892 | System and Method for Identifying a Vascular Border - A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor. | 09-29-2011 |
20110311124 | MEDICAL INSTRUMENT AND MEDICAL INSTRUMENT CONTROL METHOD - A navigation apparatus includes: a storage portion that stores three-dimensional image data of an examinee that is previously acquired; an organ extracting portion that extracts a predetermined organ from the three-dimensional image data; a first region designating portion that designates a tumor in the three-dimensional image data; a blood vessel extracting portion that extracts a plurality of blood vessels that are inside the organ from the three-dimensional image data; a blood vessel classifying portion that classifies the blood vessels into either arteries or veins; and a second region extracting portion that, based on three-dimensional image information of the blood vessels, extracts a tumor resection region that is a region that is classified based on anatomical features of the organ and that includes a tumor. | 12-22-2011 |
20120063665 | METHOD AND APPARATUS FOR QUANTITATIVE IMAGING OF BLOOD PERFUSION IN LIVING TISSUE - Embodiments provide methods and systems for imaging, and, more specifically, to a method and apparatus for quantitative imaging of blood perfusion in living tissue. Some embodiments are directed to methods of obtaining quantitative imaging of blood perfusion in living tissues using Doppler optical micro-angiography (DOMAG). | 03-15-2012 |
20120093388 | MEDICAL IMAGE PROCESSING APPARATUS, METHOD, AND PROGRAM - A medical image processing apparatus in which an index value calculation unit calculates an index value representing a characteristic of a tubular structure extracted from a three-dimensional medical image in each direction of radial visual lines orthogonal to a core line of the tubular structure at each of a plurality of points on the core line with each point as each viewpoint and a map image generation unit generates a characteristic map image representing the characteristic inside of the tubular structure by mapping the index value calculated in each direction of the radial visual lines at each point on the core line to a coordinate plane defined by a first coordinate component representing a position in a direction of the core line and a second coordinate component representing a direction of each visual line. | 04-19-2012 |
20120093389 | TEMPORAL OXIMETER - The present invention discloses a method and an apparatus for detecting change in retinal oxygen saturation over time. The method comprises the steps of capturing a first group of images of two or more wavelengths, calculating oxygen saturation of a vessel in the first group of images, storing the first group of images on a data storage device, capturing a second group of images of two or more wavelengths, calculating the oxygen saturation of a vessels in the second group of images, storing the second group of images on a data storage device, spatially registering the pair of the group of images, captured at different time and calculate the change in oxygen saturation. | 04-19-2012 |
20120093390 | QUANTITATIVE PERFUSION ANALYSIS - A system is disclosed for quantitative analysis of perfusion images comprising image elements having intensity values associated therewith. The system comprises a frequency distribution computing subsystem ( | 04-19-2012 |
20120106823 | Systems and Methods for Computer Aided Analysis of Images - Certain embodiments of the present technology provide systems, methods and computer instructions for computer aided analysis of images. In certain embodiments, for example, such a method includes: isolating a motion area in an image; segmenting the image; utilizing a support vector machine to identify a region of interest in the image; utilizing a graph-cut algorithm to refine the region of interest; and verifying the region of interest. In certain embodiments, for example, such a method further includes: aligning a set of images and/or outputting a set of aligned images sequentially. In certain embodiments, the systems, methods and computer instructions disclosed herein can be used to aid analysis of cardiac images, for example. In certain embodiments, the systems, methods and computer instructions disclosed herein can be used to aid analysis of four dimensional images, for example. | 05-03-2012 |
20120128227 | DEVICE FOR GENERATING ALTERNATIVE OF NORMAL BRAIN DATABASE | 05-24-2012 |
20120148143 | COMPACT BIOMETRIC AUTHENTICATION DEVICE AND ASSOCIATED METHODOLOGY OF IMAGING AND DETECTING LIVING-TISSUE PATTERNS - The apparatus enables biometric authentication without the risk of forgery or the like and enables living-tissue discrimination. The roughness distribution pattern of deep-layer tissue of the skin covered with epidermal tissue is detected, thereby extracting a unique pattern of the living tissue. Biometric authentication is performed based upon the detected pattern. The roughness distribution pattern of the deep-layer tissue of the skin is optically detected using difference in optical properties between the epidermal tissue and the deep-layer tissue of the skin. Long-wavelength light, e.g., near-infrared light, is used as illumination light cast onto the skin tissue. A fork structure of a subcutaneous blood vessel is used as the portion which is to be detected, for example. The portion which is to be detected is determined based upon the structure of the fork structure. The living-tissue discrimination may be made using the subcutaneous blood vessel. | 06-14-2012 |
20120155739 | LOCALIZATION OF A VALID AREA OF A BLOOD SMEAR - Automated localization of a valid area of a blood smear and, thus, localization requiring less effort and being more objective is enabled in that a picture of the blood smear pixels are classified at least into first pixels, which represent blood cells, and second pixels, which do not represent the blood cells, and the valid area is then found on the basis of a local frequency of pixel clusters of at least A | 06-21-2012 |
20120195489 | METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS - A method and apparatus for determining the hematocrit of a blood sample disposed within an analysis chamber, the method comprising the steps of: a) imaging at least a portion of the sample that contains one or more red blood cells contacting the interior surfaces of the chamber and one or more areas void of red blood cells; b) determining a representative optical density value for a plurality of image units optically aligned with portions of the red blood cells that are in contact the interior surfaces, and assigning an optical density first boundary value to those image units; c) determining a representative optical density value of a plurality of image units optically aligned with the one or more regions of the sample devoid of red blood cells, and assigning a second optical density boundary value to those image units; and d) determining the hematocrit of the sample. | 08-02-2012 |
20120201446 | COMPUTER-AIDED DETECTION (CAD) OF INTRACRANIAL ANEURYSMS - A computer-aided system identifies aneurysm suspects in | 08-09-2012 |
20120207377 | Medical imaging system - A medical imaging system for processing an original medical image is provided. The system includes a seed generator for receiving the original medical image representing an original blood vessel and to generate coarse seeds on a basis of vesselness feature in respect to every pixel of the original blood vessel represented by the medical image, and a seed processor for receiving the coarse seeds and for processing the coarse seeds to select a set of refined seeds on a basis of the regression profile for each of the coarse seed by using random forest classification, such that the set of refined seeds are selected from the coarse seeds such that the set of refined seeds adapted to lie on a corrected blood vessel. | 08-16-2012 |
20120207378 | Medical Imaging System for Segementing Blood Vessel - A medical imaging system to segment an original blood vessel of a body part represented by an original medical image is provided. The system includes an image analyzer for receiving and the original medical image to analyze the original medical image to provide a Hessian Eigen analysis comprising a first data and a second data mapped to each pixel of the medical image, and an image identifier for receiving the Hessian Eigen analysis and for identifying seed points from the pixels by processing the first data and the second data along with a vesselness property, wherein the seed points are used for segmenting the original blood vessel to provide a corrected medical image representing a corrected blood vessel. | 08-16-2012 |
20120237108 | OPHTHALMOLOGY INFORMATION PROCESSING APPARATUS AND METHOD OF CONTROLLING THE SAME - There is provided an ophthalmology information processing apparatus that allows to easily grasp a change in each part in continuously captured ophthalmology images. The ophthalmology information processing apparatus reads out a plurality of continuous captured images stored in a storage unit. An image analysis unit aligns the captured images. The ophthalmology information processing apparatus calculates the variation and position information of the pixel information of each pixel between the captured images based on the alignment information. An image generation unit generates a three-dimensional image which is displayed on a display unit simultaneously with the captured images. | 09-20-2012 |
20120237109 | HISTOLOGY ANALYSIS - The invention relates to histology analyses, and in particular, to the assessment of pathological tissues to aid in the diagnosis of disease characterised by specific pathologies, for example cancer. The invention provides methods and apparatuses for analysing tissue samples, as well as computer-readable media programmed with software for carrying out these diagnostic methods. | 09-20-2012 |
20120263369 | METHOD AND APPARATUS FOR COMPRESSING IMAGING DATA OF WHOLE BLOOD SAMPLE ANALYSES - A method and apparatus for analyzing white blood cells (WBCs) within a whole blood sample quiescently residing within a chamber is provided. The chamber is defined by at least one transparent panel, and the whole blood sample includes at least one colorant operable to differentially identify at least one WBC type from another WBC type within the sample. The method includes the steps of: a) creating at least one image of the sample quiescently residing within the chamber; b) identifying portions of the sample image, with each portion representing a single WBC; c) compressing the sample image portions using a first compression algorithm; and d) one of compressing a remainder of the sample image not included in the portions using a second compression algorithm, or discarding the remainder. | 10-18-2012 |
20120269420 | Image Processing and Machine Learning for Diagnostic Analysis of Microcirculation - Automated quantitative analysis of microcirculation, such as density of blood vessels and red blood cell velocity, is implemented using image processing and machine learning techniques. Detection and quantification of the microvasculature is determined from images obtained through intravital microscopy. The results of quantitatively monitoring and assessing the changes that occur in microcirculation during resuscitation period assist physicians in making diagnostically and therapeutically important decisions such as determination of the degree of illness as well as the effectiveness of the resuscitation process. Advanced digital image processing methods are applied to provide quantitative assessment of video signals for detection and characterization of the microvasculature (capillaries, venules, and arterioles). The microvasculature is segmented, the presence and velocity of Red Blood Cells (RBCs) is estimated, and the distribution of blood flow in capillaries is identified for a variety of normal and abnormal cases. | 10-25-2012 |
20120275682 | TREE STRUCTURE EXTRACTION APPARATUS, METHOD AND PROGRAM - Tree structures corresponding to a first linear structure and a second linear structure are constructed from medical image data including the first linear structure and the second linear structure, each repeatedly branching from an origin and extending in directions away from the origin in such a manner to become wider. Each of a first root node corresponding to a root node in the first tree structure and a second root node corresponding to a root node in the second tree structure is connected to each node, based on the characteristic that each of the first and second linear structures repeatedly branches from the origin and extends in directions away from the origin in such a manner to become wider, by using, with respect to each node, a cost function that weights a cost representing a probability of connection of each of a plurality of edges connectable to each node. | 11-01-2012 |
20120275683 | METHOD AND SYSTEM FOR DETECTING COLORIMETRIC ABNORMALITIES IN VIVO - A system and method for detection of colorimetric abnormalities within a body lumen includes an image receiver for receiving images from within the body lumen. Also included are a transmitter for transmitting the images to a receiver, and a processor for generating a probability indication of presence of colorimetric abnormalities on comparison of color content of the images and at least one reference value. | 11-01-2012 |
20120288180 | FUNCTIONAL IMAGING - A method includes determining, via a processor, functional information about tissue of interest in image data for a functional image acquisition based on reference information generated based on non-tissue of interest. | 11-15-2012 |
20120288181 | VESSEL CENTERLINE DETERMINATION - A method of centerline determination for a tubular tissue in a medical image data set defined in a data space, comprising receiving at least one start point and one end point inside a tubular tissue volume; automatically determining a path between said points that remains inside said volume; automatically segmenting said tubular tissue using said path; and automatically determining a centerline for said tubular tissue from said segmentation, wherein said receiving, said determining a path and said segmenting, said determining a centerline are all performed on a same data space of said medical image data set. | 11-15-2012 |
20130011042 | SYSTEM AND METHOD FOR ESTIMATING EXTRACORPOREAL BLOOD VOLUME IN A PHYSICAL SAMPLE - One method for estimating the extracorporeal blood volume in a portion of a physical sample includes: comparing a portion of an image of the sample with a template image of known extracorporeal blood volume indicator; tagging the portion of the image of the sample with a blood volume indicator according to the template image that is matched to the portion of the image of the sample; and estimating the extracorporeal blood volume in at least a portion of the physical sample, associated with the portion of the image of the sample, according to the blood volume indicator. | 01-10-2013 |
20130094750 | METHODS AND SYSTEMS FOR SEGMENTATION OF CELLS FOR AN AUTOMATED DIFFERENTIAL COUNTING SYSTEM - A method of identifying individual cells in an image of a cytological preparation. The method includes the steps of obtaining an image of a cytological preparation including a plurality of cells; identifying a first region of the image, the first region having a region boundary encompassing at least one lobe, wherein the first region includes at least one cell; detecting at least one circle within the first region, where the at least one circle substantially covers the at least one lobe of the first region; and if the first region has more than one circle, splitting the region into at least two subregions. | 04-18-2013 |
20130108141 | IMAGE PROCESSING APPARATUS | 05-02-2013 |
20130170729 | METHOD AND APPARATUS FOR IDENTIFYING RETICULOCYTES WITHIN A BLOOD SAMPLE - A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values. | 07-04-2013 |
20130170730 | METHOD AND APPARATUS FOR AUTOMATED PLATELET IDENTIFICATION WITHIN A WHOLE BLOOD SAMPLE FROM MICROSCOPY IMAGES - A method and apparatus for identifying platelets within a whole blood sample. The method includes the steps of: a) adding at least one colorant to the whole blood sample, which colorant is operable to tag platelets; b) disposing the blood sample into a chamber defined by at least one transparent panel; c) imaging at least a portion of the sample quiescently residing within the chamber to create one or more images; and d) identifying one or more platelets within the sample using an analyzer adapted to identify the platelets based on quantitatively determinable features within the image using a analyzer, which quantitatively determinable features include intensity differences. | 07-04-2013 |
20130208972 | METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS - A method and apparatus for determining the hematocrit of a blood sample disposed within an analysis chamber, the method comprising the steps of: a) imaging at least a portion of the sample that contains one or more red blood cells contacting the interior surfaces of the chamber and one or more areas void of red blood cells; b) determining a representative optical density value for a plurality of image units optically aligned with portions of the red blood cells that are in contact the interior surfaces, and assigning an optical density first boundary value to those image units; c) determining a representative optical density value of a plurality of image units optically aligned with the one or more regions of the sample devoid of red blood cells, and assigning a second optical density boundary value to those image units; and d) determining the hematocrit of the sample. | 08-15-2013 |
20130216119 | System for Suppressing Vascular Structure in Medical Images - A system generates medical image data representing smaller vessels including capillaries of a region of patient anatomy. An image data processor identifies pixels of larger vessels in individual images of difference images where the larger vessels have a size exceeding a predetermined threshold size. The image data processor generates an enhanced visualization small vessel image comprising substantially peak luminance values of individual pixels exclusive of pixels of the identified larger vessels. A peak luminance value of an individual pixel is generated in response to a peak luminance value of luminance values of pixels, spatially corresponding to the individual pixel and present in images comprising the plurality of temporally sequential individual difference images. An output processor outputs substantially peak luminance values as a vessel image. | 08-22-2013 |
20130272596 | METHODS FOR GENERATING A RECONSTRUCTED TREE STRUCTURE FROM MEDICAL IMAGE DATA - A computer-implemented method of post-processing medical image data is provided. The method includes receiving tracked image data representative of multiple blood vessels, generating a binary tree structure for the multiple blood vessels based on a parent-child relationship between branches of the multiple blood vessels, generating a likelihood model for determining a validity of the branches of the multiple blood vessels, and generating a likelihood score for each branch based on the respective branch's compatibility with the likelihood model. The method also includes generating a reconstructed tree for the multiple blood vessels. Compatible branches are included in the reconstructed tree, while invalid branches are not included in the reconstructed tree. | 10-17-2013 |
20130272597 | METHOD TO OBTAIN 3D IMAGES OF A FLOWING REGION BENEATH AN OBJECT USING SPECKLE REFLECTIONS - A method for imaging a flowing media within static regions includes obtaining a plurality of signals using the speckle properties of the flowing media. The plurality of signals are compared to one another such as by subtraction. The static regions are removed from the plurality of signals by the comparison. The remaining signals are combined (such as by summing) to produce an image of the flowing media. | 10-17-2013 |
20130279788 | Measuring Volume and Constituents of Cells - A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells. | 10-24-2013 |
20130279789 | DEVICE AND METHOD FOR DETERMINING OBJECTS IN A COLOR RECORDING - A device for determining objects in a color recording has an identifier, a feature extractor and a classifier. The identifier is implemented to identify the connected regions whose size or shape correspond to a predetermined condition from a plurality of connected regions existing in a binary image derived from a color recording based on a size or a shape of these connected regions. The feature extractor is implemented, for each of the identified connected regions, to extract a feature set from the color recording. The classifier is implemented to classify the identified connected regions into at least two disjunct groups based on the extracted feature sets for the identified connected regions. | 10-24-2013 |
20130301901 | SYSTEM AND METHOD FOR ESTIMATING A QUANTITY OF A BLOOD COMPONENT IN A FLUID CANISTER - A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marker; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister. | 11-14-2013 |
20130322729 | PROCESSING A VIDEO FOR VASCULAR PATTERN DETECTION AND CARDIAC FUNCTION ANALYSIS - What is disclosed is a non-contact system and method for determining cardiac function parameters from a vascular pattern identified from RGB and IR video signals captured simultaneously of a region of exposed skin of a subject of interest. In one embodiment, a video of a region of exposed skin is captured using a video camera that captures color values for pixels over visible channels and an IR camera that measures pixel intensity values in wavelength ranges of interest. Pixel intensity values are processed to generate a vascular binary mask that indicates pixel locations corresponding to the vascular pathways. The IR images are registered with corresponding data from the camera's visible channels such that pixels that correspond to the vascular pattern can be isolated in each frame of the video of visible color data. Once processed, pixels associated with the isolated vascular patterns are analyzed to determine desired cardiac function parameters. | 12-05-2013 |
20140003701 | METHOD AND SYSTEM FOR IDENTIFICATION OF CALCIFICATION IN IMAGED BLOOD VESSELS | 01-02-2014 |
20140003702 | DETERMINATION OF SPATIAL PROXIMITY BETWEEN FEATURES OF INTEREST IN BIOLOGICAL TISSUE | 01-02-2014 |
20140023261 | DISPLAY PROCESSING METHOD AND APPARATUS - A disclosed method includes: identifying an axis that is a straight or curved line inside of a space; first generating plural surface regions that are orthogonal to the identified axis; second generating, from a first vector provided at each vertex of an unstructured grid disposed inside of the space, a second vector at each point of plural points on a surface region for each of the generated plural surface regions; and displaying an arrow corresponding to the generated second vector. | 01-23-2014 |
20140029835 | METHOD AND APPARATUS FOR DETERMINING BLOOD FLOW REQUIRED, METHOD AND APPARATUS FOR PRODUCING BLOOD FLOW IMAGE, AND METHOD AND APPARATUS FOR PROCESSING MYOCARDIAL PERFUSION IMAGE - A method of determining a required blood flow includes obtaining morphological information of a coronary artery in a cardiac image, segmenting the cardiac image into at least one myocardial region based on the morphological information of the coronary artery, and determining a blood flow required for each of the at least one myocardial region. | 01-30-2014 |
20140064595 | APPARATUS AND METHOD FOR DETERMINING THE COAGULATION TIME OF BLOOD - An apparatus and a method for determining the coagulation time of blood are shown. Surface waves are injected into a blood sample ( | 03-06-2014 |
20140133733 | Cell Feature-Based Automatic Circulating Tumor Cell Detection - An automated method for detecting circulating tumor cells in a microscopic image of a blood sample includes receiving, by a computer, a plurality of low-resolution images, each low resolution image providing a representation of the blood sample with one of a plurality of stains applied. The computer determines a threshold value for each of the plurality of stains based on the low resolution images and identifies a list of potential cells based on the threshold values. A gating process is performed on the list of potential circulating tumor cells to identify one or more likely or highly likely circulating tumor cells. The computer presents the subset of the low-resolution images in a verification interface comprising one or more components allowing a user to confirm that a respective low-resolution image included in the subset of the low-resolution images includes one or more circulating tumor cells. | 05-15-2014 |
20140185906 | Device and Method for Erythrocyte Morphology Analysis - The disclosure provides a device and a method for performing morphological analysis for erythrocytes, wherein the method for performing morphological analysis for erythrocytes comprises: collecting a morphological image of each of cells in a sample through a Charge Coupled Device (CCD) after amplifying the sample through an automatic microscope; segmenting and positioning the image and extracting target feature parameters after digitizing the image through an image-digital converter; isolating morphological feature parameters of each of the erythrocytes through a classifier established on the basis of the neural network, and normalizing each type of the morphological feature parameters of the erythrocytes through a feature fusion device established on the basis of fuzzy clustering; performing a statistical analysis on each type of normalized parameters obtained or performing a comprehensive statistical analysis according to a plurality of types of parameters, and expressing the result of the statistical analysis or the comprehensive statistical analysis in the form of graph or numerical table, thereby judging whether the morphology of the erythrocyte is normal. The source and property of the erythrocytes can be identified according to the detection for each type of the erythrocytes with the abnormal morphology. | 07-03-2014 |
20140185907 | DIAGNOSTIC SYSTEM - A diagnostic system comprises a spectral image pickup means that picks up a spectral image in a predetermined wavelength region in a body cavity and obtains spectral image data, an image processing means that obtains, from the spectral image data, an index-value for discriminating between a diseased portion and a healthy portion, and generates and outputs an indicator image based on the index-value, and a monitor on which the indicator image is displayed, wherein, for each pixel of the spectral image, the image processing means defines β obtained by a predetermined expression as the index-value, while using the spectral image data P | 07-03-2014 |
20140205175 | PROCESSING SOURCE VIDEO FOR REAL-TIME ENHANCEMENT OF A SIGNAL OF INTEREST - What is disclosed is a system and method for real-time enhancement of an identified time-series signal of interest in a video that has a similar spatial and temporal structure to a given reference signal, as determined by a measure of closeness. A closeness measure is computed for pixels of each image frame of each channel of a multi-channel video to identify a time-series signal of interest. The intensity of pixels associated with that time-series signal is modified based on a product of the closeness measure and the reference signal scaled by an amplification factor. The modified pixel intensity values are provided back into the source video to generate a reconstructed video such that, upon playback of the reconstructed video, viewers thereof can visually examine the amplified time-series signal, see how it is distributed and how it propagates. The methods disclosed find their uses in remote sensing applications such as telemedicine. | 07-24-2014 |
20140205176 | OPTICAL PLATELET COUNTER METHOD - Platelets or blood cells are detected in a fluid sample by adjusting a focal depth of a microscope through a range of values, the microscope having a mounted sample and an objective lens adapted with one or both of (a) a spherical aberration correction unmatched to a utilized cover plate for the sample, or (2) a numerical aperture unmatched to a utilized illumination source for the sample. Images are recorded at different specific focal depths and in multiple z planes of a fluid bearing the platelets, where the position of platelets may overlap on different of the multiple z planes that are recorded, the images recorded through the cover plate, thus causing the generation of a specific light-dark pattern indicative of platelets at particular positions and at multiple depths in the fluid media. The images are analyzed for the specific light-dark pattern. | 07-24-2014 |
20140219539 | IMAGE DIAGNOSTIC DEVICE AND IMAGE ASSESSMENT METHOD - Provided is an image diagnostic device with which the start and end of the in-flow of a contrast medium are automatically assessed. An image diagnostic device assesses the start and end times of the in-flow of a contrast medium into organs in a lifeform which is a subject. The image diagnostic device comprises: an input unit ( | 08-07-2014 |
20140270458 | Portable Blood Count Monitor - Devices, systems, and methods are disclosed for determining the number and type of blood cells in a blood sample. The blood sample is collected and held in a slide. In the slide, the blood sample is separated and channeled into at least two sampling chambers, one for red blood cells, another for white blood cells, and optionally yet another for platelets. The sampling chambers have wetting agents, lysing agents, staining agents, or the like therein to mix with the blood and facilitate cell count. The slide is placed in a portable slide analyzer where the sampling chambers are illuminated and images of the sampling chambers are taken. These images are converted into electronic form and sent by a communications module of the slide analyzer to a remote external location where the images are analyzed to determine the number and type of blood cells in the blood sample. | 09-18-2014 |
20140270459 | Particle Identification System, Cartridge And Associated Methods - A method for determining fluorescently labeled particles within a sample in presence of sample movement includes determining spatial shift between sequentially captured first and second images of the sample by using a third image of the sample, wherein the spatial shift is at least partially induced by the sample movement; and spatially correlating events between the first and second images, while accounting for the spatial shift. A method for providing a fluidic assay cartridge with dried reagents includes depositing a plurality of mutually incompatible liquid reagents in a respective plurality of mutually separated areas of the fluidic assay cartridge, and drying the plurality of mutually incompatible liquid reagents to form the dried reagents. A fluidic assay cartridge with dried reagents includes a plurality of mutually separated dried reagents, located within the fluidic assay cartridge, wherein the plurality of mutually separated dried reagents have a respective plurality of mutually different compositions. | 09-18-2014 |
20140307940 | AUTOMATED SET-UP FOR CELL SORTING - Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters. | 10-16-2014 |
20140334712 | METHOD AND APPARATUS FOR DETERMINING HEMOGLOBIN BASED PARAMETERS IN AN UNLYSED BLOOD SAMPLE - A method and apparatus for determining hemoglobin concentration is provided. A method aspect includes the steps of: a) depositing an unlysed, substantially undiluted blood sample into an analysis chamber adapted to quiescently hold the sample for analysis; b) imaging the sample in a region of the analysis chamber where the height of the chamber is no more than about twenty microns (20μ) or no less than about two microns (2μ), to produce image signals representative of the optical density of the imaged region; c) determining a sample representative optical density value using the image signals representative of the optical density of the imaged region; and d) determining the hemoglobin concentration of the sample using the sample representative optical density value. | 11-13-2014 |
20140348412 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 11-27-2014 |
20140355863 | IMAGE PROCESSING APPARATUS, METHOD AND MEDICAL IMAGE DEVICE - An image processing apparatus according to an embodiment includes an input extraction unit, and a parameter estimation unit. The input extraction unit configured to extract, from time sequence images of medical images obtained by performing a blood perfusion imaging scan on a tissue, a region where a main vessel supplying blood input to the tissue is located as an input part and obtain, based on the input part, a time-density sequence of the blood input as an input time sequence. The parameter estimation unit configured to estimate parameters in a model representing the change of the blood flow at each point in the tissue with the input time sequence, based on the input time sequence, the model and the time sequence images, wherein the parameters include a delay undergone by the blood when flowing from the input part to each point in the tissue. | 12-04-2014 |
20140369589 | DIAGNOSIS ASSISTANCE APPARATUS, DIAGNOSIS ASSISTANCE METHOD, AND COMPUTER READABLE STORAGE MEDIUM - A diagnosis assistance apparatus for assisting a diagnosis using schemas includes a storage section that stores a plurality of different schemas each configured by a figure representing a body region, an acquiring section that acquires results of a plurality of examinations that are performed on an examination target, a schema refining section that refines a schema of a body region related to a disease that is predicted from the acquired examination results, from the schemas step-by-step in accordance with progress of the examinations, and a displaying section that displays the schema refined by the schema refining section. | 12-18-2014 |
20150117745 | Method, system and a service for analyzing samples of a dried liquid - This invention relates to a method, a system and a service for analyzing biological liquids like blood and to assess the quality of such liquid. The analysis is made on a plurality of dried drops of the liquid as samples on a substrate, and involves scanning the substrate to create an image of the dried samples on the substrate. The image of the samples is processed in order to segment and qualify the samples into images of defined sample drops for further processing, whereafter they are grouped into at least one group of samples. The samples are analyzed to retrieve the total areas having at least one predetermined color and to retrieve the total areas for each predetermined color in the drops, whereby a ratio is calculated of the total area of the defined sample drops versus the total areas of the at least one predetermined color areas to achieve a quality indication of the liquid. | 04-30-2015 |
20150356731 | IMAGE PROCESSING DEVICE, STORAGE MEDIUM, AND IMAGE PROCESSING METHOD - A device comprises: a nucleus-candidate-region extracting section that extracts, from a captured image obtained by image-capturing a sample piece including a target cell having a nucleus, a nucleus candidate region corresponding to the nucleus; a basic-probability-information acquiring section that acquires, for each of a plurality of determination subject regions determined on the basis of the nucleus candidate region extracted by the nucleus-candidate-region extracting section, basic probability information indicating probability that an image in the determination subject region is an image of the target cell, on the basis of a feature amount of the image of the determination subject region; and a probability-information calculating section that calculates probability information indicating probability that an image in a display subject region corresponding to the nucleus candidate region is the image of the target cell, on the basis of the basic probability information acquired for each of the plurality of determination subject regions. | 12-10-2015 |
20160026852 | Imaging Blood Cells - This document describes methods, systems and computer program products directed to imaging blood cells. The subject matter described in this document can be embodied in a method of classifying white blood cells (WBCs) in a biological sample on a substrate. The method includes acquiring, by an image acquisition device, a plurality of images of a first location on the substrate, and classifying, by a processor, objects in the plurality of images into WBC classification groups. The method also includes identifying, by a processor, objects from at least some classification groups, as unclassified objects, and displaying, on a user interface, the unclassified objects and at least some of the classified objects. | 01-28-2016 |
20160078276 | GRAPHICAL USER INTERFACE FOR ANALYSIS OF RED BLOOD CELLS - Methods and systems for generating a graphical user interface for analysis of red blood cells. The method generates a first view of the graphical user interface by highlighting red blood cells in an image that are classified into at least one group indicated by a user input. The method also generates a second view by extracting individual red blood cells being classified into the at least one group indicated by the user input from the image of red blood cells and displaying them group-wise. | 03-17-2016 |
20160103058 | IMAGE FORMING CYTOMETER - The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means ( | 04-14-2016 |
20160148038 | SYSTEMS, APPARATUS, AND METHODS FOR ANALYZING BLOOD CELL DYNAMICS - Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event. | 05-26-2016 |
20160189378 | IMAGE PROCESSING APPARATUS, NON-TRANSITORY COMPUTER READABLE MEDIUM, AND IMAGE PROCESSING METHOD - An image processing apparatus includes a number-of-target-cells estimating unit for estimating, on the basis of a feature of a target sample, the number of target cells included in the target sample, and a detection parameter setting unit for setting, on the basis of the estimated number of target cells, a detection parameter regarding a process of detecting target cells in a captured image of the target sample. | 06-30-2016 |