Entries |
Document | Title | Date |
20080204551 | Miniature microscope camera - A hand-held microscope includes a rigid tripod stand with adjustable legs, a visual display component, an imaging detector and an optical assembly comprising an imaging lens and an objective lens housed within an imaging tube. Multiple illumination sources can be used in the microscope, including LED or laser diode sources. The microscope can also include interchangeable imaging tubes that enable bright field, dark field, fluorescence and other imaging modalities. | 08-28-2008 |
20080246839 | MICROSCOPE APPARATUS AND MICROSCOPE SYSTEM - It is possible to check for observation success or failure and the observation history without waiting for observation to be completely finished, thus saving time and energy required for observation, and avoiding lost opportunities for observation of precious samples etc. Provided is a microscope apparatus including an image acquisition unit for acquiring a plurality of frame images while varying a plurality of parameters; an image saving unit for successively saving the frame images acquired by the image acquisition unit; a property-information saving unit for saving property information in which identifying information of the saved frame images is associated with the parameters; and a control unit for controlling these units, wherein the control unit saves updated property information in the property-information saving unit each time the frame image is saved in the image saving unit. | 10-09-2008 |
20090015666 | AUTOMATED PROTEIN CRYSTALLIZATION IMAGING - An apparatus that automatically captures, stores and analyzes images of crystallization experiments contained in a number of crystallization plates. The apparatus includes a plate nest capable of accommodating protein crystallization plates of a plurality of different types, image acquisition optics, including an objective lens and an image capturing device, for focusing an image of a crystallization well, a light source including a bright field illumination device and a dark field illumination device, a nest positioning controller for moving the position of the plate nest with respect to the image acquisition optics to align various selected wells with said objective lens for imaging of the content of the wells. A database stores experiment information associated with each of the crystallization plates, the experiment information including identification of specific crystal forming parameter values, each of the crystallization plates is identified in said database by a unique identification code. A crystallization imaging controller controls crystallization imaging by retrieving the experiment information for each crystallization plate inserted into the apparatus, and controlling the nest positioning controller and the image acquisition optics in accordance with the retrieved experiment information. The apparatus captures multiple images of each crystal site using different light source and polarization conditions, and processes the multiple images to form extended fused images of each crystal site. | 01-15-2009 |
20090102918 | MICROSCOPE IMAGE PICKUP SYSTEM - A microscope image pickup system includes: alight source; an object lens; a display device; a record device; a capture device for performing a preview mode in which an image of the test object obtained by the object lens is repeatedly captured and a plurality of captured images are continuously displayed on the display device, or an image record mode in which the image of the test object is captured and the captured image is recorded on the record device; an illumination light amount control device for controlling the amount of light of the illumination light; and a system control device for controlling an operation of the illumination light amount control device depending on the preview mode or the image record mode performed by the capture device. | 04-23-2009 |
20090109285 | CONTROLLABLE MICRO LIGHT ASSEMBLY - A micro light interface assembly for a microscopic machine vision inspection system includes a micro light assembly. The micro light assembly provides addressable light emitting elements arranged around the periphery of an aperture having an aperture dimension DAPMIN that is smaller than a barrel dimension DBAR of the inspection system objective lens. The aperture may be located along the optical axis and within the working distance of the objective lens such that the light emitting elements are closely arranged around a field of view. The micro light interface assembly may be held and operated through a connection element that may be used for the interchanging the micro light interface assembly with a touch probe, in some embodiments. | 04-30-2009 |
20090141126 | Fully Automatic Rapid Microscope Slide Scanner - Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging. | 06-04-2009 |
20090141127 | IMAGE PROCESSING SYSTEM, IMAGING SYSTEM, AND MICROSCOPE IMAGING SYSTEM - An image processing system comprising an image data acquisition unit for acquiring captured image data, with a first image processing unit for performing first image processing relating to color correction and gradation correction on the image data, a second image processing unit for performing second image processing relating to color correction based on a Color Appearance Model on the image data, a parameter calculation unit for calculating an image processing parameter used in the first image processing from the image data before the second image processing and the image data after the second image processing, and a control unit for setting the image processing parameter to the first image processing unit. | 06-04-2009 |
20090167850 | METHOD FOR IDENTIFYING GUIGNARDIA CITRICARPA - The present invention refers to a computer vision system for identifying the fungus | 07-02-2009 |
20090185034 | IMAGING DEVICE FOR MICROSCOPE - An image pickup unit obtains a specimen image by picking up the observation image of a specimen produced by a microscope. An installation state information obtainment unit obtains installation state information indicating the installation state of an optical member inserted into the observation light path of the microscope. An exposure condition setup unit sets an exposure condition to be used when the image pickup unit picks up the observation image to obtain a specimen image in a second magnification ratio, on the basis of installation state information used when the image pickup unit obtained a specimen image in a first magnification ratio by picking up the observation image, and on the basis of installation state information to be used when the image pickup unit obtains a specimen image in the second magnification ratio, which is a different magnification ratio from the first magnification ratio, by picking up the specimen image. | 07-23-2009 |
20090185035 | MICROSCOPE SYSTEM, CONTROL METHOD USED FOR MICROSCOPE SYSTEM, AND RECORDING MEDIUM - A microscope system which is capable of changing observation states by driving various optical members and which includes a history record unit for recording history data related to a microscope operation history, a selection unit for selecting one or more microscope operation items from among a plurality of microscope operation items, and a state reproduction unit for reproducing a microscope state on the basis of a microscope operation item(s) selected by the selection unit and on the basis of a microscope operation history related to history data recorded in the history record unit. | 07-23-2009 |
20090195646 | MICROSCOPE COMPRISING A CAMERA CONNECTION AND A CAMERA ADAPTER - A microscope comprising a camera connection in a image beam path is suggested. A camera adapter and a camera can be adapted to the camera connection, and the microscope can be used to reproduce the image of a sample on a sensor of the camera. Imaging of the beam path in the camera adapter comprises an intermediate imaging with a pupil plane having reduced beam diameter next to the pupil plane, and at least one optical means can be inserted into the reproduction beam path in the region of the reduced beam cross-section. An optical means or an interchangeable device comprising a plurality of optical means, such as filters, plane-parallel plates or wedge plate, is integrated into the pupil plane in the camera adapter. | 08-06-2009 |
20090201366 | IMAGING APPARATUS AND MICROSCOPE - Providing an imaging apparatus and a microscope capable of taking two-dimensional images of a sample at a plurality of observation positions different in the optical axis direction at the same time. The apparatus includes an image-forming lens | 08-13-2009 |
20090231421 | Image processing apparatus and image processing method - An image processing apparatus includes a first spectrum estimating unit for reading the image information from a storage unit and estimating a spectrum of an object based on the read image information; a dye amount estimating unit for estimating dye amounts included in the object using the estimated spectrum; a second spectrum estimating unit for synthesizing a first spectrum using the estimated dye amounts; a spectrum subtractor for calculating a difference spectrum by subtracting the first spectrum from the spectrum; a dye amount correcting unit for correcting at least a part of the estimated dye amounts; a third spectrum estimating unit for synthesizing a second spectrum using the corrected dye amount; a spectrum adder for synthesizing a third spectrum by adding the second spectrum and the difference spectrum; and an image synthesizer for synthesizing a display image from the third spectrum. | 09-17-2009 |
20090231422 | MICROSCOPE EXAMINATION APPARATUS - The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen. | 09-17-2009 |
20090237500 | MOLECULAR IMAGING APPARATUS AND METHOD - A nuclear imaging chain ( | 09-24-2009 |
20090237501 | METHOD AND AN APPARATUS FOR LOCALIZATION OF SINGLE DYE MOLECULES IN THE FLUORESCENT MICROSCOPY - A method and apparatus are provided for obtaining a sub-resolution spatial information of a sample labeled with at least one type fluorescent label. The sub-resolution spatial information has localization information about the positions of fluorescent molecules of the at least one type fluorescent label in at least one spatial direction. The method acquires localization image data by employing fluorescence localization microscopy. The acquired localization image data is processed to obtain the localization information about the positions of fluorescent molecules of the at least one type fluorescent label in at least one spatial direction. The step of processing includes determining in each of the detected images of the series the positions of the barycenters of the detected fluorescence emission distributions from the single fluorescent molecules of the one or more fluorescent labels in at least one spatial direction. | 09-24-2009 |
20090237502 | Microscope apparatus - Provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images, and a recording unit which records at least one of an image group including one or more of the images captured during a predetermined period among a period of a time-lapse capturing performed by the time-lapse imaging unit or an image group including one or more of the images picked at predetermined time intervals among the period of the time-lapse capturing performed by the time-lapse imaging unit. Thus, data generated in time-lapse photography are managed favorably in a microscope apparatus provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images. | 09-24-2009 |
20090278923 | DEFECT REVIEW METHOD AND APPARATUS - A defect review apparatus comprises a storage for receiving and storing defect information concerning an inspection objective captured by a wafer inspection system, an image acquisition unit for capturing images concerning the inspection objective and a process unit for acquiring data for defect review based on the defect information by using the image acquisition unit. The process unit makes a decision as to whether a cluster representative of a set or gang of defects exists in the defect information read out of the storage unit and when the presence of the cluster is determined, acquires an image of a defective portion forming part of the cluster and additional data in respect of the inspection objective by using the image acquisition unit on the basis of a distributive feature of the cluster. | 11-12-2009 |
20090284590 | METHOD AND SYSTEM FOR CONTROLLING THE POSITION OF A MICROSCOPE LENS - A method for controlling the position of a microscope lens comprising receiving a reference signal corresponding to a reference position of the microscope lens; receiving a measurement signal corresponding to an actual position of the microscope lens; receiving a deviation signal characteristic of a predetermined positional deviation from the reference position; and using the measurement signal, the deviation signal and the reference signal to generate a positional control signal for use in setting the position of the microscope lens. | 11-19-2009 |
20090303321 | System and Computer Readable Medium for Pre-focus of Digital Slides - Methods and apparatus are provided for computing focus information prior to scanning digital microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation. | 12-10-2009 |
20090309963 | MICROSCOPE IMAGING SYSTEM, ITS STORAGE MEDIUM STORING EXPOSURE ADJUSTMENT PROGRAM, AND ITS METHOD - A microscope imaging system includes obtaining a second image area being a focus area composed of one or more pixels arbitrarily specified in a first image area indicated by an entire area or a predetermined area of an outputted image; generating a first brightness histogram of the first image area and a second brightness histogram of the second image area; calculating a relative brightness value of the second image area against the first image area by detecting a feature point of the second brightness histogram and calculating a position corresponding to a feature point of the second brightness histogram in the first brightness histogram; and controlling an imaging drive unit for driving an imaging unit until the brightness value reaches the calculated one. | 12-17-2009 |
20090315987 | RAPID DETECTION OF REPLICATING CELLS - The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance. | 12-24-2009 |
20090322869 | METHOD FOR OBSERVING CELLS, CHIP AND DEVICE - A method for observing cells, a chip and a device are provided. The method includes: (1) a camera obtaining dynamically the position of cell, the direction and speed of flow in the microchannel within the chip on stage through a microscope and transferring the data to a computer, (2) the computer collecting real-time data from the camera and analyzing it, calculating the relation between the position of cell and pressure needed in the assay, at the same time comparing the result obtained with the real-time pressure fed back by micro pressure devices and received by the computer, and inputting controlling commands to micro pressure devices; (3) based on the commands, micro pressure devices changing the pressure of two ends of microchannel in the chip to adjust the direction and speed of flow in the microchannels of chip so as to regulate the position of cell in the flow. Observing of cells can be completed quickly with accuracy according to the invention. The present invention can be applied in dynamic study for cell in scientific research, medical detection and teaching. | 12-31-2009 |
20090322870 | MICROSCOPE IMAGING APPARATUS AND ITS SYSTEM - A microscope imaging apparatus capable of communicating with a computer includes a communication unit receiving imaging interval information transmitted from the computer, and a computer activation unit activating the computer on a basis of the imaging interval information. | 12-31-2009 |
20100007727 | Automated measurement of concentration and/or amount in a biological sample - Provided are methods, computer implemented methods, and devices for machine vision. The methods and devices are capable of quantifying the amount of a particular color resulting from a particular stain in a sample stained with multiple agents. | 01-14-2010 |
20100033560 | Method and Apparatus of Tilted Illumination Observation - A tilted illumination observation method and observation device with easy adjustment, high speed, good reproducibility and low cost is provided. A high resolution tilt image of a specimen is obtained by extracting the blurring on the scanning spot occurring during beam tilt from the image (step | 02-11-2010 |
20100045789 | APPARATUS, METHOD AND ARTICLE TO PERFORM ASSAYS USING ASSAY STRIPS - An assay system includes an optical imager to acquire high resolution images of assay strips (e.g., lateral flow immunochromatographic test strips) and performs image processing to identify individual assay strips and determine results for each assay strip, by quantifies the presence or absence of test signal line(s) and control signal line(s). Assay strips may be in a holder or carrier contained in a specimen container also holding a specimen. The assay system automatically logs all results and data to a database that stores a high resolution image of the original immunochromatographic assay, the values of test line(s) and control line(s), and the test result. A user interface directs an end user through operation. | 02-25-2010 |
20100060729 | System for creating microscopic digital montage images - An imaging apparatus. The imaging apparatus may find an area in which a specimen is present, then focus on the specimen and capture images of the specimen during continuous stage motion. | 03-11-2010 |
20100066823 | METHOD AND DEVICE FOR PRODUCING AN IMAGE OF A THIN LAYER OF AN OBJECT - A method for producing an image of a layer of an object by a wide field optical element on a resolving detector. The object is illuminated in a focused manner on at least one object plane having at least two binary illuminating patterns. The corresponding images are detected. Light and/or the dark areas of the illuminating patterns completely cover the object when the illuminating pattern is superimposed. A layer image determined from the detected images, includes a partial segment that respectively reproduces a partial area of the object that is arranged inside the light area of one of the used illuminating patterns. Edges are arranged at a distance from the edges of the light area about at least one predefined minimum distance. | 03-18-2010 |
20100073472 | Intergrated virtual slide and live microscope system - A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view. | 03-25-2010 |
20100091101 | MICROSCOPE FOR VIRTUAL-SLIDE CREATING SYSTEM - A microscope for virtual-slide creating system has a stage for holding the specimen, a transmitted-light illumination optical system for illuminating the specimen with transmitted light, an objective, a tube lens and an image capture unit. The objective is configured as a dry system of infinity-corrected type with an object-side numerical aperture of 0.8 or greater and a focal length for d-line rays in a range from 8 to 20 mm. The tube lens has a focal length in a range from 160 to 280 mm. The image capture surface of the image capture unit has a long side of 12 mm or longer and a pixel size (μm) satisfying the following condition: | 04-15-2010 |
20100091102 | Toy camera set - A toy camera set. The camera set includes a camera that can be attached to a variety of different toy optical accessories. By way of example, the toy optical accessories may include a toy microscope, a toy periscope, or a toy binocular. The camera can be used to take a picture through the microscope, etc. The camera can be attached to one accessory and then attached to another accessory so that a single camera can be used with a number of toy optical devices. The kit includes an instruction guide that instructs a user how to attach the various toy accessories to the camera. | 04-15-2010 |
20100103253 | METHOD AND MICROSCOPIC SYSTEM FOR SCANNING A SAMPLE - A method for scanning a sample using an electrically or electronically controllable microscope, includes scanning the sample so as to generate a plurality of images of the sample, each of the plurality of images corresponding to at least one of a different region of the sample and a different time. The microscope is controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network. The plurality of images are classified and/or the scanning is influenced based on the analyzing. | 04-29-2010 |
20100103254 | PHOTOGRAPHING CONTROL DEVICE, MICROSCOPE AND PROGRAM - The present invention relates to a photographing control device, microscope and program that can simply confirm whether time lapse photography is being executed normally or not. | 04-29-2010 |
20100103255 | AUTOMATIC ADJUSTMENT METHOD OF MICROSCOPE IMAGE AND MICROSCOPE SYSTEM - The automatic adjustment method of a microscopic image for automatically adjusting an image on the basis of the lightness of the microscopic image includes distinguishing an observation pixel being an observation target in the image from a non-observation pixel not being an observation target on the basis of the lightness of each pixel of the image, determining a representative value for representing the lightness of the image on the basis of the lightness of a selection pixel identified as the observation pixel and adjusting the lightness of the image on the basis of the representative value. | 04-29-2010 |
20100118133 | METHOD AND DEVICE FOR PRODUCING THIN SECTIONS OF A SAMPLE BY MEANS OF AN IMAGE RECOGNITION SYSTEM - A method and a device for producing thin sections of a sample by means of a microtome is described, in which a camera acquires at least one image of a surface generated by sectioning of the sample. With the aid of an evaluation device, the image of the surface is evaluated in terms of predefined characteristic values of a section quality. As a function of the characteristic values that are identified, a decision is then made as to whether the section of the sample is accepted or not. | 05-13-2010 |
20100141750 | Image Forming Method and Microscope Device - More images than spatial modulation components of a lighting light are acquired, and a least square method is applied to the imaged plurality of images to obtain signal components. Accordingly, a ultra-resolution microscope which uses a spatially-modified lighting light to illuminate a sample, arithmetic-processes acquired images to thereby demodulate a given spatial modulation, and obtains a high-resolution sample image, wherein a high-resolution image reduced in noise components can be obtained. | 06-10-2010 |
20100141751 | IMAGING SYSTEM FOR MICROSCOPE AND MICROSCOPE SYSTEM - An imaging system for a microscope comprises: an imaging unit imaging an optical image from a microscope; a display unit displaying the imaged image; a specifying unit specifying at least a given position on the displayed image to set a measurement target; a measurement and drawing unit performing measurement of the measurement target and drawing of the measurement target, as well as making a measurement value obtained by the measurement displayed at a predetermined position on the screen; a magnification change determination unit determining whether there has been a change in an observation magnification of the microscope; a control unit performing, when it is determined that there has been a change in the observation magnification of the microscope after the measurement value is displayed, an output in accordance with the change. | 06-10-2010 |
20100141752 | Microscope System, Specimen Observing Method, and Computer Program Product - A microscope system includes an image acquiring unit that acquires a specimen image formed by capturing a specimen multi-stained by a plurality of pigments using a microscope; a pigment amount acquiring unit that acquires a pigment amount of each pigment staining a corresponding position on the specimen, for each pixel of the specimen image; and a pigment selecting unit that selects a display target pigment from the plurality of pigments. The system also includes a display image generating unit that generates a display image where a staining state of the specimen by the display target pigment is displayed, on the basis of the pigment amount of the display target pigment in each pixel of the specimen image; and a display processing unit that displays the display image on a display unit. | 06-10-2010 |
20100141753 | Optimizing Virtual Slide Image Quality - Systems and methods for assessing and optimizing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan. | 06-10-2010 |
20100149325 | MICROSCOPIC IMAGING APPARATUS AND MICROSCOPIC IMAGING METHOD - The microscopic imaging apparatus includes a system controlling unit for obtaining a VD time setting value, and for obtaining the number of electric charge subtracting pulses, a synchronization signal generating unit for generating a vertical synchronization signal on the basis of the VD time setting value output from the system controlling unit and the horizontal synchronization signal, and a timing generating unit for extracting the electric charge of the imaging device by supplying the horizontal synchronization signal by the number of electric charge subtracting pulses to the imaging device as the electric charge subtracting pulses, and for generating a read pulse synchronous with the vertical synchronization signal in order to stop the accumulation of the electric charge of the imaging device after exposure is started. | 06-17-2010 |
20100157042 | IMAGE DATA PROCESSING DEVICE, ITS STORAGE MEDIUM, AND ITS METHOD - An image data processing includes: obtaining first image data; outputting the first image data to the image display devices; obtaining an attention area composed of one or more arbitrarily specified pixels from the first image outputted to the image display devices ; displaying a color chart whose hue and chroma are gradually changed toward around the color corresponding to the image data of the attention area; obtaining arbitrarily selected color information from the displayed color chart; obtaining a plurality of combinations of the attention area and the color information corresponding to the attention area and calculating a color parameter on the basis of the obtained plurality of combinations; converting the color of the obtained image data on the basis of the color parameter; and outputting the image data whose color is converted, to the image display devices as a second image. | 06-24-2010 |
20100177187 | METHOD FOR DETERMINING AN IN-FOCUS POSITION AND A VISION INSPECTION SYSTEM - In one embodiment of the present invention, a method is disclosed for determining a difference between a sample position and an in-focus position, as well as a vision inspection system. In a first step image data depicting a sample is captured. Next, a feature set is extracted from the image data. Thereafter, the feature set is classified into a position difference value, corresponding to the difference between the sample position and the in-focus position, by using a machine learning algorithm that is trained to associate image data features to a position difference value. | 07-15-2010 |
20100177188 | BIOLOGICAL SAMPLE IMAGE ACQUIRING APPARATUS, BIOLOGICAL SAMPLE IMAGE ACQUIRING METHOD, AND PROGRAM - A biological sample image acquiring apparatus includes: a sample stage on which a biological sample is placed and which can move in a direction; an objective lens magnifying a region of the biological sample; an imaging device imaging the region magnified by the objective lens; a stage on which the imaging device or the objective lens is placed and which can move in a corresponding direction of the direction; a first moving mechanism moving the sample stage so that a target region of the biological sample is located at an imaging range; a second moving mechanism moving the stage in the corresponding direction at a movement speed obtained by multiplying a movement speed of the sample stage by a magnification of the objective lens; and an imaging controller starting the exposure of the imaging device before the sample stage moved by the first moving means is stopped. | 07-15-2010 |
20100177189 | METHOD AND APPARATUS FOR CONTROLLING A MICROSCOPE - In accordance with the present invention there is provided a method for controlling a microscope to scan a microscope slide. By analysing an overview image it is determined quantatively which swathe contains the most image detail and an optimum scanning order can subsequently be determined relative to the swathe determined as having the most detail. By scanning the swathe with the most detail first a good focus characteristic can be established for a dynamic focussing system and prediction errors in the dynamic focus system are likely to be low when scanning subsequent swathes. | 07-15-2010 |
20100177190 | MICROSCOPY SYSTEM WITH REVOLVABLE STAGE - A microscopy system includes an image focusing module, a stage for supporting a sample, image collection unit for collecting sliced images of the sample acquired by the image focusing module, and an image fusion unit for fusing sliced images of the sample acquired from different observation angles. The stage supports the sample and is configured to be revolvable around a rotational axis which is substantially perpendicular to an extending direction from the sample to the image focusing module so that enabling the image focusing module to acquire sliced images of the sample from different observation angles. The image fusion unit is used for remapping the sliced images acquired from different observation angles into a reference coordinate system, converting anisotropic voxels resolution of the sliced images to isotropic resolution, and fusing the sliced images into a final image. | 07-15-2010 |
20100182417 | AUTOMATIC FOCUSING APPARATUS, MICROSCOPE, AND AUTOMATIC FOCUSING METHOD - In acquisition of an image of cells, a focal position is accurately set at highly active cells rather than focusing on dead cells. Provided is an automatic focusing apparatus ( | 07-22-2010 |
20100182418 | SURGICAL MICROSCOPE FOR OBSERVING AN INFRARED FLUORESCENCE AND CORRESPONDING METHOD - A surgical microscope for observing an infrared fluorescence includes a camera system | 07-22-2010 |
20100182419 | METHODS AND APPARATUS FOR IMAGING AND PROCESSING OF SAMPLES IN BIOLOGICAL SAMPLE CONTAINERS - Disclosed herein is a holder for biological sample containers such as well plates. The holder comprises a flat vacuum bed surrounded by a seal. A container is placed within the seal and a vacuum is applied, pressing and flattening the lower surface of the sample container against the flat vacuum bed. Samples in all portions of the container may then be imaged without the need to refocus on each portion of the container. For imaging, a sample in a well can be illuminated by a beam of light arranged so that a part or all of the sample is illuminated by direct rays that have not passed through the well plate. The beam is redirected to other parts of the well if a single illumination does not cover the whole well, so that the sample to be imaged using a series of partial images. | 07-22-2010 |
20100188496 | SYSTEMS AND METHODS FOR SELECTIVE DETECTION AND IMAGING IN COHERENT RAMAN MICROSCOPY BY SPECTRAL-TEMPORAL EXCITATION SHAPING - A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system. | 07-29-2010 |
20100188497 | MICROSCOPIC IMAGE CAPTURING APPARATUS, MICROSCOPIC IMAGE CAPTURING METHOD, AND STORAGE MEDIUM HAVING A MICROSCOPE IMAGE CAPTURING PROGRAM STORED THEREON - In a correction data storing unit of a digital camera which captures a microscopic image, image data of a light image without a sample, image data obtained by using a filter for removing a defective portion for the light image without a sample, image data where a region without being corrected (or a region being corrected) is set in the light image without the sample, and shading correction data calculated from image data obtained by setting a mask region where data after being corrected is set to 0 are stored. An operator obtains, captures, records, and stores an observation image satisfactory for great-looking by using arbitrary shading correction data. In this way, a captured image satisfactory for great-looking is obtained by making a suitable shading correction according to a shading characteristic, which is caused by an optical system. | 07-29-2010 |
20100194873 | METHOD AND DEVICE FOR MICROSCOPICALLY EXAMINING A SAMPLE, COMPUTER PROGRAM AND COMPUTER PROGRAM PRODUCT - The invention relates to a method for microscopically examining a sample, wherein, in an overview mode, first an overview image of the sample composed of a large number of individual images is recorded through a microscope ( | 08-05-2010 |
20100201800 | MICROSCOPY SYSTEM - A reproduction apparatus includes an attribute information recording unit that records image attribute information in which the attribute values indicating the attributes of each image are set; a target image selecting unit that selects a target image from images; a search condition setting unit that sets the search conditions that are the attribute values related to the target image in the image attribute information; a reproduction information creating unit that creates information for reproduction by setting image attribute information that satisfies the search conditions in the image attribute information; a search condition selecting unit that selects the search conditions as reproduction search conditions; and a search result reproducing unit that causes a display unit to display an image to be reproduced with respect to the image attribute information set in the information for reproduction when the reproduction search conditions are selected, and reproduces search results related to the target image. | 08-12-2010 |
20100208052 | MICROSCOPE DEVICE AND PROGRAM - A user operates an operating section to cause a motorized stage to move, and observes and checks an entire sample that is disposed on the motorized stage. When the motorized stage is stopped for a predetermined reference time or longer, a controller recognizes the position where the stage is stopped as a position for time-lapse observation, and records as observation position information that observation position. After observation of the entire sample, the controller sequentially moves the motorized stage to the observation positions indicated by the observation position information, on the basis of the recorded observation position information, whereby the user observes the sample at each observation position and decides on a final observation position. | 08-19-2010 |
20100208053 | CULTURE MICROSCOPE APPARATUS - A culture microscope apparatus has an illumination unit to apply excitation light to the specimen, a specimen observing portion to observe light generated from the specimen due to the excitation light, and a dimmer unit to dim the excitation light that has penetrated the specimen. | 08-19-2010 |
20100214403 | PHOTOMICROSCOPY SYSTEM, IMAGE INPUT DEVICE, AND AUTOMATIC EXPOSURE METHOD - A photomicroscopy system includes a microscope unit which outputs an enlarged image of a subject as a light flux, an image capturing unit which forms an image of the light flux output by the microscope unit and converts the formed image into digital data, a sensitivity changing unit which changes a sensitivity of the image capturing unit, and a computing unit which obtains an exposure time by using the digital data captured by the image capturing unit in a state where the sensitivity is increased to the high sensitivity after instructing the sensitivity changing unit to increase the sensitivity of the image capturing unit to the high sensitivity while calculating the exposure time for obtaining a suitable brightness by the image capturing unit, and sets the sensitivity of the image capturing unit to a low sensitivity after the exposure time is set in the image capturing unit. | 08-26-2010 |
20100214404 | FLUORESCENCE FOCAL MODULATION MICROSCOPY SYSTEM AND METHOD - A fluorescence focal modulation microscopy system and method is disclosed for high resolution molecular imaging of thick biological tissues with single photon excited fluorescence. Optical sectioning and diffraction limited spatial resolution are retained for imaging inside a multiple-scattering medium by the use of focal modulation, a technique for suppressing the background fluorescence signal excited by the scattered light. The focal modulation microscopy system has a spatial phase modulator inserted in the excitation light path, which varies the spatial distribution of coherent excitation light around the focal volume periodically at a preset frequency. A fluorescence focal modulation image is formed on a display with the demodulated fluorescence, while a confocal image is available simultaneously. | 08-26-2010 |
20100214405 | MICROSCOPE IMAGING SYSTEM AND METHOD FOR ITS OPERATION - A microscope imaging system for capturing a fluorescent observation image includes: an imaging unit capturing an observed image as a colored image; a plurality of fluorescent cubes; a fluorescent cube switch unit arranging any fluorescent cube on an optical observation path by switching the plurality of fluorescent cubes; a fluorescent cube determination unit determining the fluorescent cubes arranged on the optical observation path; a gray scale adjustment unit adjusting the ratios of the color components when each pixel configuring the observed image captured by the imaging unit is converted from a color to a gray scale depending on the wavelength characteristic of the determined fluorescent cube; and a conversion unit converting each pixel configuring the observed image captured by the imaging unit from the color to the gray scale on the basis of the adjusted ratios of the color components. | 08-26-2010 |
20100231703 | METHOD AND SYSTEM FOR DIGITIZING A SPECIMEN WITH FLUORESCENT TARGET POINTS - The present invention relates to a method and an automated fluorescent imaging system for digitizing a specimen with fluorescent target points on a microscope slide. The method uses the fluorescence microscope system for detecting and scanning said fluorescent target points. The method comprises the steps of marking the position of said specimen on said slide by visible marking means to define a specimen area containing said specimen and said fluorescent target points; capturing a bright field image of at least a portion of the slide at a first optical magnification, said portion(s) containing the specimen area and determining, from the visible marking means, a position of target fields falling within said specimen area; and scanning the target fields of the specimen area at a second optical magnification higher than said first optical magnification, said scanning including focusing on at least a part of said target fields. | 09-16-2010 |
20100245557 | INJECTION OF SECONDARY IMAGES INTO MICROSCOPE VIEWING FIELDS - Systems and methods for injecting secondary images into viewing fields of surgical microscopes are disclosed. Some exemplary embodiments may provide secondary image injection in a picture-in-picture arrangement, thereby allowing a surgeon to simultaneously view the one or more secondary images and the surgical field through the oculars of the surgical microscope. Some exemplary embodiments may allow injection of secondary images including live video, such as live images from an endoscope, as well as previously obtained images, such as stored images from pre-operative studies. | 09-30-2010 |
20100253774 | BIOLOGICAL IMAGE PRESENTATION DEVICE, BIOLOGICAL IMAGE PRESENTATION METHOD, PROGRAM, AND BIOLOGICAL IMAGE PRESENTATION SYSTEM - A biological image presentation device includes: an acquisition unit acquiring, at multiple positions on an axis as a standard of a biological region, images of sections orthogonal to the axis; a determination unit determining an image as a standard and an image for comparison with the image as a standard from among a plurality of images acquired by the acquisition unit; an extraction unit extracting, from the image as a standard, a position where a change of luminance value equal to or larger than a defined value is present; a detection unit detecting a position corresponding to the position extracted by the extraction unit from the image for comparison; a division unit dividing the image as a standard on the basis of the position extracted by the extraction unit; a mapping unit mapping the image for comparison to an area corresponding to each divided area of the image as a standard while modifying so as to conform to the shape of the divided area; and a display control unit switching and displaying an image for display in a display area by using the image as a standard and an image mapped by the mapping unit. | 10-07-2010 |
20100259605 | SYSTEMS AND METHODS FOR VOLUMETRIC TISSUE SCANNING MICROSCOPY - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. | 10-14-2010 |
20100265323 | SYSTEM FOR AND METHOD OF FOCUSING IN AUTOMATED MICROSCOPE SYSTEMS - The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations. | 10-21-2010 |
20100277580 | MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE - The invention relates to a spot generator ( | 11-04-2010 |
20100277581 | MICROSCOPE - A microscope, which moves an objective lens along an observation optical axis with respect to a specimen, includes an imaging unit and a supporting unit. The imaging unit has an imaging lens, which is arranged on the observation optical axis and forms an observation image of the specimen, and an imaging element, which is arranged on the observation optical axis and takes the observation image, and is optically connected to the objective lens by a parallel light flux. The supporting unit fixedly supports the imaging unit, and movably supports the objective lens. | 11-04-2010 |
20100289887 | Automated transient image cytometry - A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity. | 11-18-2010 |
20100289888 | IMAGE ACQUISITION APPARATUS, METHOD FOR CONTROLLING IMAGE ACQUISITION APPARATUS, AND MICROSCOPE SYSTEM - A pixel shifting unit moves the relative position between the luminous flux entering an image pickup device and the device to a plurality of predetermined positions in a predetermined order. A control unit controls the device, and allows the image of a subject image formed by the luminous flux on the photoreception surface of the device when the relative position is in any of the plurality of predetermined positions. A combination unit combines the plurality of obtained images to generate a high-resolution image. A prediction unit predicts a shooting environment when the device hereafter shoots an image of the subject image on the basis of a change of at least two images. A setting control unit controls a setting of a shooting condition when the image of the subject image is shot on the basis of a result of the prediction of the shooting environment. | 11-18-2010 |
20100295932 | IMAGE OBTAINING APPARATUS, IMAGE SYNTHESIS METHOD AND MICROSCOPE SYSTEM - An image sensor captures an observation image formed on a light-receiving surface. An order adjustment unit makes the image sensor capture an original entire-area image being a picture of the observation image for an entire area of the light-receiving surface under a first exposure condition, and makes the image sensor capture a partial-area image being a picture of the observation image for only a partial area of the light-receiving surface under a second exposure condition. A synthesizing unit synthesizes the original entire-area image and the partial-area image to obtain an entire-area image having a wider dynamic range than the original entire-area image. | 11-25-2010 |
20100309304 | Method and Device for the Reconstruction of the Shape of an Object from a Sequence of Sectional Images of Said Object - A method of reconstructing the volume of an object from a sequence of section images, the images corresponding to different positions and/or orientations of an acquisition plane and being subject to uncertainties, the method comprising:
| 12-09-2010 |
20100309305 | PHOTOGRAPHING APPARATUS AND MICROSCOPE SYSTEM - A photographing control unit comprising a drive signal generator, an analog front end, a synchronization signal generation unit, and a system control unit controls an imager under a predetermined photographing condition, so that the imager photographs an observation image of a sample observed by a microscope and formed on a light receiving surface of the imager. A computing unit obtains inputs of a plurality of photographing parameters, determines a photographing condition based on the obtained photographing parameters, and sets the photographing condition for the photographing control unit. A display unit displays the designable ranges of the photographing parameters. Here, when the computing unit obtains the input of a priority parameter, it changes the designable range of the plurality of photographing parameters other than the priority parameter based on the priority parameter and causes the display unit to display the designable range after the change. | 12-09-2010 |
20100309306 | IMAGE ACQUIRING APPARATUS, IMAGE ACQUIRING METHOD, AND IMAGE ACQUIRING PROGRAM - In acquisition of a micro image of a sample S by a micro image acquiring unit | 12-09-2010 |
20100315501 | ELECTRONIC IMAGING FLOW-MICROSCOPE FOR ENVIRONMENTAL REMOTE SENSING, BIOREACTOR PROCESS MONITORING, AND OPTICAL MICROSCOPIC TOMOGRAPHY - An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET, whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management. | 12-16-2010 |
20100315502 | SYSTEM AND METHOD FOR REMOTE CONTROL OF A MICROSCOPE - A system and method for remote control of an automated microscope via a widely distributed network. | 12-16-2010 |
20100321484 | BIOLOGICAL SAMPLE IMAGE ACQUIRING APPARATUS, BIOLOGICAL SAMPLE IMAGE ACQUIRING METHOD, AND BIOLOGICAL SAMPLE IMAGE ACQUIRING PROGRAM - A biological sample image acquiring apparatus includes: an objective lens magnifying a region of a biological sample; an imaging device imaging the region magnified by the objective lens; a movement controller moving the focus of the objective lens in the thickness direction of the target region of the biological sample and moving the image of the region, which magnified by the objective lens to be imaged onto an imaging device, in an in-plane direction; and a biological sample image acquiring unit acquiring a biological sample image of the region by exposing the imaging device to light while the movement controller is moving the image of the region. | 12-23-2010 |
20100328445 | MICROSCOPE SYSTEM - A microscope system is constructed by a light guiding optical system | 12-30-2010 |
20110001815 | MICROSCOPE APPARATUS - To organize and store a plurality of types of image information acquired by a plurality of image acquisition methods at different timings. There is provided a microscope apparatus comprising a time counting unit for counting time, a plurality of different image acquisition units, and a storage unit for storing image information, when acquired by any one of the image acquisition units, and timing information counted by the time counting unit, by having them associated with each other. Even if the image acquisition units acquire different types of image information at different timings, it is possible, by using the timing information as a clue, to call up the image information stored in the storage unit in a chronological order. | 01-06-2011 |
20110013008 | DEVICE FOR ACQUIRING IMAGE OF LIVING BODY - Observation of a living body sample from multiple directions can be measured in a short time and with a convenient structure. One two-dimensional detector is arranged in order to pick up the image of light emitted from a sample on a sample holder, and connected with a display for displaying the image picked up by means of the two-dimensional detector. In order to observe the sample on the sample holder from a plurality of directions and to introduce the image of light emitted from the sample in each direction to the two-dimensional detector, a light guide optical system including a multi-reflector assembly consisting of reflectors is provided. A main image formation lens for forming on the two-dimensional detector a plurality of images introduced by the light guide optical system is arranged between the two-dimensional detector and the light guide optical system. Auxiliary image formation lenses for correcting according to a light path length difference an image formed on the two-dimensional detector a main image formation lens is arranged between the main image formation lens and the light guide optical system. | 01-20-2011 |
20110013009 | REFLECTION MICROSCOPE FOCUSING - The invention relates to a method of focusing, by an imaging device, of images of a substantially planar surface of an object including the step of determining the attitude of the surface of the object with respect to a reference plane by scanning this surface by means of at least one triangulation sensor along exactly two parallel lines in the reference plane. The invention further includes the steps of splitting the surface of the object into areas of a size corresponding to the size of a taken image, inferring from the attitude respective elevations of the image areas, and adjusting, for each area, the focus with respect to the elevation thereof. | 01-20-2011 |
20110013010 | MICROSCOPE CONTROLLER AND MICROSCOPE SYSTEM HAVING THE MICROSCOPE CONTROLLER - A microscope controller that performs operations for controlling operations of motorized units configuring a microscope system includes a touch panel unit that accepts an input made with an external physical contact and has a display function, a controlling unit for setting a display area as a functional area by assigning an image for operating the motorized unit to a certain display area on the touch panel unit and for generating a control instruction signal for controlling the motorized unit in accordance with a contact operation performed for the motorized unit corresponding to the functional area upon detection of an input made in the functional area, and a communication controlling unit for transmitting the control instruction signal to an external device that controls an operation of the motorized unit. | 01-20-2011 |
20110013011 | ARRANGEMENT AND METHOD FOR FOCUSING A MULTIPLANE IMAGE ACQUISITION ON A PROBER - A focused multi-planar image acquisition in real time even while a test object is moving, is achieved with a system and a method for a focused multi-planar image acquisition in a prober. When a surface of a test object is positioned laterally in relation to tips of separated probe needles, a microscope is focused on the surface of the test object at a first time and on a plane of the probe needles at a second time. The objective lens is provided with a microscope objective lens focusing system, which can focus the objective lens, independently of a vertical adjustment drive of the microscope, on the surface of the test object in a first focal plane and in a second focal plane, which is on a level with the probe needle tips. | 01-20-2011 |
20110025837 | METHOD OF IMAGING A SAMPLE - A method of imaging a sample comprises the steps of: -providing S | 02-03-2011 |
20110037846 | HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS - A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying z-displacements. | 02-17-2011 |
20110037847 | Fully Automatic Rapid Microscope Slide Scanner - Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging. | 02-17-2011 |
20110043618 | INTEGRATED CALIBRATION SAMPLE BAY FOR FLUORESCENCE READERS - A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay. | 02-24-2011 |
20110043619 | Resolution-Enhanced Luminescence Microscopy - Described is a method for the high spatial resolution luminescence microscopy of a sample which is marked with marking molecules which can be activated by way of a switch-over signal such that only then can they be stimulated to emit luminescent radiation, wherein the method has the following steps a) introducing the switch-over signal onto the sample such that only a partial amount of the marking molecules present in the sample are activated, wherein, partial regions exist in the sample, in which partial regions only exactly one molecule, which is activated by the switch-over signal, is located inside a volume which is delimited by a diffraction-limited maximum resolution of a detection of luminescent radiation, b) stimulating the activated molecules to emit luminescent radiation, c) detecting the luminescent radiation with diffraction-limited resolution and d) generating image data from the luminescent radiation recorded in step c), wherein the marking molecules, which emit the geometric locations of the luminescent radiation, indicate with a spatial resolution which is increased to above the diffraction limit, wherein e) the detection of the luminescent radiation in step c) or the generation of the image data in step d) comprises a non-linear increase, which prefers higher intensities, of recorded luminescent radiation in order to enhance the spatial resolution to above the diffraction-limited resolution. | 02-24-2011 |
20110058030 | DIGITAL MICROSCOPE - A digital microscope for viewing the surface of an object comprises a housing having a proximal end and a distal end. The distal end forms an opening to the housing. A sensor that receives light reflected from the surface of an object is located towards the proximal end of the housing. The sensor converts the light to a digital image. A lens that focuses light reflected from the object onto the sensor is located within the housing between the sensor and the object to be viewed. A reflective member is located within the opening. In use, light is reflected from the object to the sensor and a portion of the reflected light is directed via the reflective member such that the surface of the object can be viewed simultaneously from two different directions. | 03-10-2011 |
20110074944 | SYSTEM AND METHODS FOR GENERATING A BRIGHTFIELD IMAGE USING FLUORESCENT IMAGES - A method for generating a brightfield type image, which resembles a brightfield staining protocol of a biological sample, using fluorescent images is provided. The steps comprise acquiring two or more fluorescent images of a fixed area on a biological sample, mapping said fluorescent image into a brightfield color space, and generating a bright field image. Also provided is an image analysis system for generating a brightfield type image of a biological sample using fluorescent images. | 03-31-2011 |
20110085031 | FLUORESCENT MICROSCOPE AND REMOTE CONTROL SYSTEM THEREOF - The present invention relates to a fluorescent microscope and a remote control system thereof. The present invention reduces the size of the fluorescent microscope to facilitate transportation and management and be disposed in a narrow place such as the inside of the incubator or the clean bench, etc. and observes the samples through a remote control, thereby making it possible to improve the user convenience. | 04-14-2011 |
20110085032 | MICROSCOPE CAMERA AND MOBILE TERMINAL HAVING THE SAME - Disclosed is a microscope camera and a mobile terminal using the same, wherein the camera includes a lens unit including a plurality of lenses for enlarging an object, an illumination unit for illuminating the object, a camera module configured to receive an enlarged light image of an object from the lens unit, convert the image to an electrical signal and convert the electrical signal to a DC data, and an interface unit configured to connect the camera module to a mobile terminal for transmitting the DC data to the mobile terminal, whereby an image of an enlarged object can be outputted to a display unit of the mobile terminal or a desired image can be captured, thereby enhancing an excellent portability and mobility. | 04-14-2011 |
20110090326 | SYSTEM AND METHOD FOR IMAGING WITH ENHANCED DEPTH OF FIELD - A method for imaging is presented. The method includes acquiring a plurality of images corresponding to at least one field of view using an imaging device having an objective and a stage for holding a sample to be imaged. Furthermore, the method includes determining a figure of merit corresponding to each pixel in each of the plurality of acquired images, wherein the figure of merit comprises a discrete approximation to a gradient vector. The method also includes synthesizing a composite image based upon the determined figures of merit. | 04-21-2011 |
20110090327 | SYSTEM AND METHOD FOR IMAGING WITH ENHANCED DEPTH OF FIELD - A method for imaging is presented. The method includes acquiring a plurality of images corresponding to overlapping fields of view at a plurality of sample distances using an imaging device having an objective and a stage for holding a sample to be imaged. Moreover, the method includes determining a figure of merit corresponding to each pixel in each of the plurality of acquired images. The method also includes synthesizing a composite image based upon the determined figures of merit. | 04-21-2011 |
20110090328 | PORTABLE MICROSCOPE - A portable microscope includes an image sensing module and an objective lens ascending/descending module. The objective lens ascending/descending module includes a rotatable roller, a sliding track member and an objective lens assembly. A first thread structure is formed on an inner wall of the rotatable roller. The sliding track member is disposed within the rotatable roller, and includes at least two parallel sliding tracks for defining a channel. The objective lens assembly is coupled to the sliding track member and slidable along the channel. A second thread structure mating with the first thread structure is formed on an external surface of the objective lens assembly. Upon rotation of the rotatable roller, the objective lens assembly is moved along the channel of the sliding track member, thereby adjusting the size of an image acquired by the image sensing module. | 04-21-2011 |
20110090329 | METHOD FOR EMULATION OF A PHOTOLITHOGRAPHIC PROCESS AND MASK INSPECTION MICROSCOPE FOR PERFORMING THE METHOD - In mask inspection, the defects that are of interest are primarily those that will also show up on wafer exposure. The aerial images generated in the resist and by emulation should be as identical as possible. This also applies to methods in which an overall structure that is divided into at least two substructures on at least two masks. A system and a method are provided for emulating a photolithographic process for generating on a wafer an overall structure that is divided into at least two substructures on at least two masks. The method includes generating aerial images of the at least two substructures, at least one of the aerial images being captured with a mask inspection microscope; correcting, by using a processing unit, errors in the at least one aerial image captured with a mask inspection microscope; and overlaying the aerial images of the at least two substructures to form an overall aerial image with the overall structure. | 04-21-2011 |
20110096157 | MICROSCOPY IMAGING - Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels. | 04-28-2011 |
20110102571 | Microscope Apparatus and Microscope Observation Method - The number of seams between magnified images in a created virtual slide is reduced to make the virtual slide clear and sharp. Provided is a microscope apparatus including an objective lens that collects light from a sample on a slide; a focus position detecting section that detects a focus position of the objective lens with respect to the sample; a focus state adjustment section that adjusts a focus state with respect to the sample based on a detection result from the focus position detecting section; and a magnified-image acquisition section that acquires a magnified image of each part of the sample, in which, if the focus position detected by the focus position detecting section is changed by more than a predetermined threshold with respect to a focus state in which an adjacent magnified image was obtained, the focus state adjustment section limits the adjustment in the focus state to the predetermined threshold or less. | 05-05-2011 |
20110102572 | MICROSCOPE SYSTEM AND METHOD OF CONTROLLING A MICROSCOPE SYSTEM - A microscope system includes an accommodation unit, a stage, an optical system, an image pickup unit, a movement mechanism, a control unit, an image processing unit, and a display unit. The accommodation unit is capable of accommodating a plurality of specimens. On the stage, each of the specimens loaded from the accommodation unit is placed. The optical system includes a lens for spherical aberration correction. The image pickup unit is capable of capturing a partial image of each of the specimens placed on the stage, via the optical system. The movement mechanism moves the lens for spherical aberration correction along an optical axis. The control unit controls movement of the lens for spherical aberration correction by the movement mechanism and correct spherical aberration. The image processing unit combines the partial images captured by the image pickup unit and generate a composite image. The display unit displays the generated composite image. | 05-05-2011 |
20110109735 | VIRTUAL MICROSCOPE SYSTEM - A virtual microscope system capable of obtaining a stained sample image and a statistical data of spectra in a short period of time is provided, the virtual microscope system includes an image obtaining unit for obtaining a stained sample image, a spectrum obtaining unit for obtaining a spectrum of the stained sample image, an optical path setting unit for setting an optical path of a light flux passed through the stained sample with respect to the image obtaining unit and the spectrum obtaining unit and a control unit for controlling to repeat obtaining the stained sample image by the image obtaining unit and obtaining the spectrum of the stained sample image by the spectrum obtaining unit in the observation field of the stained sample to create a virtual slide and a spectrum table of the stained sample. | 05-12-2011 |
20110109736 | System and Method for Producing an Optically Sectioned Image Using Both Structured and Uniform Illumination - A first image data set of the real-world object is received at a processor where the real-world object was illuminated with substantially uniform illumination. A second image data set of the real-world object is received at the processor where the real-world object was illuminated with substantially structured illumination. A high pass filter is applied to the first-image data set to remove out-of-focus content and retrieve high-frequency in-focus content. The local contrast of the second-image data set is determined producing a low resolution local contrast data set. The local contrast provides a low resolution estimate of the in-focus content in the first-image data set. A low pass filter is applied to the estimated low resolution in-focus data set, thus making its frequency information complementary to the high-frequency in-focus data set. The low and high frequency in-focus data sets are combined to produce an optically-sectioned data set of the real-world object. | 05-12-2011 |
20110115895 | MULTIDIRECTIONAL SELECTIVE PLANE ILLUMINATION MICROSCOPY - A method and device for multi-directional selective plane illumination microscopy is provided. A detector focal plane is alternately illuminated with at least two counter-propagating, coplanar light sheets, and an image of a specimen cross-section positioned in the focal plane is detected while only one light sheet illuminates the specimen. The wavefront of the illumination beams may be deformed with adaptive optics using feedback from light transmitted through the specimen. Multiple images of the specimen cross-section may be detected at different times and specimen positions and orientations to produce multi-view image stacks which may be processed using image fusion to produce a reconstructed image representation of the specimen. Additionally, the direction of propagation of the alternating light sheets may be pivoted in the focal plane while detecting the image. | 05-19-2011 |
20110115896 | HIGH-SPEED AND LARGE-SCALE MICROSCOPE IMAGING - An imaging system generates an image of a specimen by acquiring images of individual portions of the specimen and combining the images to form a composite image. The system moves the specimen to a set of predetermined locations such that all portions of the specimen are captured into images. At each location, images are heuristically acquired at a different distance from an acquisition lens, and the image with the sharpest focus is selected. The selected images are combined to form a composite image by computing and removing overlapping regions of the adjacent images with sub-pixel spatial accuracy. And, the system is capable of imaging thick specimens with high topological variations. | 05-19-2011 |
20110115897 | Whole Slide Fluorescence Scanner - A whole slide fluorescence digital pathology system is provided that uses a monochrome TDI line scan camera, which is particularly useful in fluorescence scanning where the signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning to provide autofocusing capability. The system also scans and analyzes image data to determine the optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off. | 05-19-2011 |
20110122242 | DIGITAL MICROSCOPY EQUIPMENT WITH IMAGE ACQUISITION, IMAGE ANALYSIS AND NETWORK COMMUNICATION - A digital microscope comprises a housing with an image acquisition, an image processing, and a network communication (APC) module. The APC module can further comprise an image capture unit, coupled to an image sensor with a view to a subject on a slide, the image capture unit receiving an image of the subject. The APC module also comprises an image processing unit, coupled to the image capture unit, the image processing unit enhancing the image with classifications. Also, a network interface of the APC module, coupled to the image processing unit and to a network, the network interface sending the enhanced image across to the network and to receive control commands, the control commands associated with the view of the subject. | 05-26-2011 |
20110128366 | INFORMATION PROCESSING APPARATUS, METHOD AND COMPUTER-READABLE MEDIUM - In one example embodiment, an information processing apparatus causes a display device to display a first image in a display range. In this embodiment, the first image is from images associated with an observation target object. The images include a first image, a second image, and a third image. In response to a request to change the display range, the information processing apparatus changes the display range at a first speed, and causes the display range to display the second image. In response to a request to terminate the change of the display range, the information processing apparatus changes the display range at a deceleration speed, and causes the display range to display the third image. | 06-02-2011 |
20110128367 | IMAGE PROCESSING APPARATUS, METHOD, AND COMPUTER-READABLE MEDIUM - In one example embodiment, an information processing apparatus displays a first image associated with an observation target object. In this example embodiment, the first image has a first zoom magnification and a first display range which has a first center position. In one example embodiment, the information processing apparatus enables a user to change the first zoom magnification by selecting a first position of the displayed first image. In response to the first position being selected, the information processing apparatus displays a second image associated with the observation target image. In this example embodiment, the second image has a second zoom magnification which is different from the first zoom magnification. The second image also has a second display range which has a second center position which is different from the first center position. In this example embodiment, the second center position corresponds to the selected position. | 06-02-2011 |
20110134232 | TWO-PHOTON MICROSCOPE WITH SPECTRAL RESOLUTION - A microscope for generating an image of a sample, the microscope includes a light source for generating a pulsed light; an optical scanner receiving the pulsed light and transmitting the pulsed light to the sample to be imaged causing the sample to emit energy; a dispersive element that receives the emitted energy from the sample, disperses the energy into its spectral elements and transmits the spectrally dispersed energy; and a camera that generates a spectrally resolved image of the sample based on the spectrally dispersed energy from the dispersive element. Also described is a method of generating spectrally resolved images of the sample. | 06-09-2011 |
20110134233 | IMAGING SYSTEM AND METHOD FOR ENHANCING MICROSCOPIC IMAGES OF UNSTAINED CELLS - According to one aspect, the present invention relates to an imaging system | 06-09-2011 |
20110141260 | Microscope apparatus and storage medium storing microscope apparatus control program - A microscope apparatus includes a monitoring optical system, an imaging unit capturing an image of an observation target through the monitoring optical system to generate a plurality of images, a correction unit disposed in the optical monitoring system and correcting various aberrations which occur due to an observation condition, and a decision unit deciding a correction amount of the correction unit based on the plurality of images generated by the imaging unit, whereby an image deterioration ascribable to the aberration occurring due to the observation condition in the microscope apparatus is appropriately and easily corrected according to a use condition of the microscope apparatus. | 06-16-2011 |
20110141261 | IMAGE PROCESSING SYSTEM, IMAGE PROCESSING APPARATUS, IMAGE PICKUP APPARATUS, METHOD, AND COMPUTER-READABLE MEDIUM - In one example embodiment, an information processing system includes an image pickup apparatus connected to a microscope having a stage configured to support an observation target object. In this example embodiment, the stage has a first position. The information processing system has a buffer having an amount of data. In response to the amount of data including a predetermined amount, the information processing system causes the stage to move from the first position to a different position. In response to the amount of data including the predetermined amount, the information processing system causes the buffer to, while the stage is moving, store images associated with the observation target object. In one example embodiment, the images are continuously captured by the image pickup apparatus. Thereafter, the information processing system, in response to the amount of data not including the predetermined amount, causes the image pickup apparatus to terminate capturing the images. | 06-16-2011 |
20110141262 | OPTICAL OBSERVATION APPARATUS WITH MULTI-CHANNEL DATA INSERTION - An optical observation apparatus has an optical image channel for viewing optical field-of-view images, a processing unit to generate a first electronic insertion image via a first electronic image channel, and a data insertion image projector for generating an optical insertion image from the first electronic insertion image and inserting that image into the optical field-of-view image. An acquisition device acquires the optical field-of-view image without the optical insertion image inserted by the data insertion image projector. A second electronic image channel has a superimposition module, that superimposes the electronic field-of-view image with an electronic insertion image and provides the superimposed images via the second electronic image channel. The processing unit generates a second electronic insertion image, provides available display data elements, and makes it possible to assemble the electronic insertion images and assign them to different electronic image channels. | 06-16-2011 |
20110141263 | Achieving Focus in a Digital Pathology System - Methods and apparatus are provided for computing focus information prior to scanning digital microscope slide data with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation. | 06-16-2011 |
20110157348 | THICKNESS-INFORMATION ACQUISITION APPARATUS, THICKNESS-INFORMATION ACQUISITION METHOD, THICKNESS-INFORMATION ACQUISITION PROGRAM AND MICROSCOPE - A thickness-information acquisition apparatus includes: an image acquisition section configured to acquire a phase-difference image of a sample; a correlation-distribution computation section configured to compute a correlation distribution of an image in the phase-difference image with respect to pixels of another image in the phase-difference image; and a thickness-information acquisition section configured to acquire information on the thickness of the sample in accordance with the correlation distribution. | 06-30-2011 |
20110157349 | STAGE CONTROL DEVICE, STAGE CONTROL METHOD, STAGE CONTROL PROGRAM, AND MICROSCOPE - A stage control device is provided and includes: an obtaining section obtaining a set of images as different visual points in all or a part of a sample set as a photographing object; a distance calculating section calculating a distance between each pixel of one image to be set as a reference in the set of images and a relative pixel in the other image; a tilt angle calculating section calculating a tilt angle of the sample using the distance calculated by the distance calculating section; and an adjusting section adjusting a tilt angle of a stage surface on which the sample is disposed so as to minimize a tilt within an angle of view of a photographed picture on a basis of the tilt angle of the sample. | 06-30-2011 |
20110157350 | ARITHMETICALLY OPERATING DEVICE, ARITHMETICALLY OPERATING METHOD, ARITHMETICALLY OPERATING PROGRAM, AND MICROSCOPE - An arithmetically operating device is provided and includes: an image acquiring portion configured to acquire phase difference images of a sample; a retrieval range setting portion configured to set a range of pixels each to be made a retrieval object in the other image in the phase difference images for pixels each to be made a representative set in one image in the phase difference images, and pixels other than the pixels each to be made the representative; a correlation calculating portion configured to calculate correlations between the pixels for the one image, and the pixels in the range set for the pixels; and a parallax calculating portion configured to calculate parallaxes for the pixels for the one image in accordance with the correlations thus calculated. | 06-30-2011 |
20110169936 | MICROSCOPE - A microscope comprising: an XY stage unit for moving a sample holding unit for holding a sample in an optional XY direction within an XY plane orthogonal to the optical axis of an image forming optical system; a display unit for displaying a sample image photographed by a photographing device for photographing a sample image formed by the image forming optical system; a rotating unit for rotating the sample holding unit around an axis perpendicular to the XY plane; and a control unit for controlling the XY stage unit and the rotating unit so that the sample image displayed on the display unit is rotated within a screen. | 07-14-2011 |
20110169937 | MODE OF ACTION SCREENING METHOD - Certain aspects of this disclosure relate to a screening method. In general terms, the screening assay comprises contacting test cells with a test compound to provide contacted test cells, obtaining values for a plurality of cytological attributes of the contacted test cells, and scoring the cells using the values to provide a likelihood score for at least one of a plurality of classifiers, where the plurality of classifiers are defined using values for cytological attributes obtained from cells that have been contacted with compounds of known mode of action. | 07-14-2011 |
20110175993 | IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD - Provided is an image processing apparatus, including: a receiver to receive an all-in-focus image, which is generated through selecting, from focus face images, representative divided images being best-focused images among images in divided regions forming the focus face images, for each of the focus face images correspondingly to the divided regions, the focus face images being obtained through imaging an object at focus positions, and information about the focus positions of the focus face images including the representative divided images; and a predicted-image generator to generate a blur-compensation predicted image corresponding to each of the focus face images through performing a blur-compensation prediction using a blur function with respect to each of the representative divided images based on the information about the focus positions of the focus face images including the representative divided images, the information being received by the receiving means. | 07-21-2011 |
20110175994 | Method and Apparatus for Imaging of Features on a Substrate - A method for imaging features on a substrate, comprising scanning the substrate and producing an image thereof, overlaying a grid model on the image, fitting the grid model to the locations of at least some of the features on the image, and extracting images of the features. | 07-21-2011 |
20110175995 | SYSTEM AND METHOD FOR RE-LOCATING AN OBJECT IN A SAMPLE ON A SLIDE WITH A MICROSCOPE IMAGING DEVICE - A method of re-locating an object in a sample is provided for a previously-scanned slide having determined objects each with corresponding stored coordinates and a stored image, the objects being mapped relative to each other. The slide is positioned on a microscope stage, stored images of the objects are visually displayed, and a target object is selected. The slide is moved to an estimated coordinate position, corresponding to the coordinates of the target object, and a field-of-view image of the sample is captured for comparison to the stored image of the target. If the target is in the image, an offset between actual coordinates of the located target and the stored coordinates of the corresponding object is determined. The slide is then moved, via the stage, from the estimated coordinate position, according to the offset, to center the target in the image. Associated systems and methods are also provided. | 07-21-2011 |
20110181710 | ARRANGEMENT AND METHOD FOR IMAGE ACQUISITION ON A PROBER - In a system and a method for capturing images in a prober, the surface of a test object is illuminated in succession with light of a first, second and third color; an image capturing device records a gray scale image of the surface; and a composite image is produced from the three gray scale images by an image evaluating device. The object is to qualitatively improve the image capturing, in order to raise the positioning accuracy by an improved display, as a result of which, finely structured test objects can be used. This object is achieved in that the lighting device is designed as a unit, controlled by the image evaluating unit, produces at least three colors and includes at least one light emitting diode (LED) as the lighting source. | 07-28-2011 |
20110187846 | SYSTEM FOR REMOTE VIEWING AND DISPLAY OF A SLIDE - A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscope slide. One method is to use a motorized microscope that can move a specimen with respect to a microscope objective. With such a system, one can capture one or more images through a microscope objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscope objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view. | 08-04-2011 |
20110193950 | Application of microscopic linear array scanner for measuring rate of change of live organisms - The invention creates a method of single lane scanning of live organisms by CCD linear array scanner to collect valid data while minimizing photonic interruption to said live organisms. The invention further creates a simple solution to upgrade manual microscopes for measuring rate of change of live organisms. A calculation method is included to measure rate of change of live organisms. | 08-11-2011 |
20110193951 | VIRTUAL MASK SYSTEM AND METHOD FOR OPERATING THE SAME - A virtual mask system includes a stage configured to retain an object, an image-capturing device configured to capture the image of the field of view of the microscope, and a processing module configured to generate a virtual mask and superimpose the virtual mask with the image of the object. In one embodiment of the present invention, a method for operating a virtual mask system includes the steps of generating a virtual mask, placing a first object on a stage, capturing at least one image of the first object, and superimposing the virtual mask with the image of the first object by adjusting a position or an inclined angle of the stage or adjusting a capturing position of an image-capturing device by considering at least the virtual mask and the image of the first object. | 08-11-2011 |
20110205351 | CULTURE OBSERVATION SYSTEM - There is provided a culture observation system by which an approximate dimension of cells which are observed by a microscope while being cultured can be recognized at one view. A culture observation system according to the invention includes a culturing cabinet | 08-25-2011 |
20110211058 | COMPACT AUTOMATED CELL COUNTER - Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm | 09-01-2011 |
20110211059 | CONTACT MICROSCOPE USING POINT SOURCE ILLUMINATION - An apparatus and a method of locating a specimen with a microscope, the microscope including two point light sources, a transparent specimen holder, a digital imaging device, a processor and a display. The method includes sequentially illuminating the two point light sources through the transparent specimen holder and across the specimen and onto the digital imaging device to create shadows associated with each of the two point light sources. Optical images of the specimen are received on the digital imaging device associated with each shadow from the two point light sources, and a disparity signal is output containing a horizontal position, a vertical position and a depth position of the specimen in the transparent specimen holder relative to the digital imaging device. A location of the specimen is determined relative to the microscope based on the disparity signal, where the transparent specimen holder intersects a unidirectional path of light from each point light source of the two point light sources to the digital imaging device and allows the specimen to move freely throughout the transparent specimen holder. | 09-01-2011 |
20110216182 | SAMPLE-IMAGE ACQUISITION APPARATUS, SAMPLE-IMAGE ACQUISITION METHOD AND SAMPLE-IMAGE ACQUISITION PROGRAM - A sample-image acquisition apparatus includes: an image taking device; a movement control section; and a sample-image acquisition section. | 09-08-2011 |
20110216183 | MICROSCOPE APPARATUS AND OBSERVATION POSITION REPRODUCTION METHOD - A microscope apparatus includes an image capturing unit, a recognition unit, a rotational shift angle calculation unit and a position reproduction unit. The rotational shift angle calculation unit calculates a rotational shift angle between a first pattern image recognized by the recognition unit from an image of the circular sample, which is obtained by the image capturing unit in a first period, and a second pattern image recognized by the recognition unit from an image of the circular sample, which is obtained by the image capturing unit in a second period later than the first period. The position reproduction unit corrects a rotational shift of the circular sample based on the rotational shift angle calculated by the rotational shift angle calculation unit, and reproduces a position of the circular sample in the first period. | 09-08-2011 |
20110216184 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, AND IMAGING APPARATUS INCLUDING OPTICAL MICROSCOPE - An information processing apparatus is provided and includes: a first storage section to store coordinates of luminance change points in a calibration pattern having a luminance distribution in two axis directions orthogonal to each other; a generation section to generate standard pattern information on a luminance distribution of a calibration image; a determination section to determine coordinates of a luminance change point of the calibration image, as coordinates of a correction luminance change point; a first calculation section to calculate a difference between the stored coordinates of the luminance change points and the coordinates of the correction luminance change points, as a distortion vector field; a second calculation section to calculate a component obtained by removing a translation component and a rotational component from the distortion vector field, as a correction vector field; and a correction section to correct an image captured by the imaging section by using the calculated correction vector field. | 09-08-2011 |
20110221881 | Virtual-Slide Creating Device - It is possible to create a virtual slide of a subject of observation in a simple configuration without setting a movement pattern in advance. Provided is a virtual-slide creating device including a stage on which a sample is mounted; an objective lens that collects light from the sample; a relative movement mechanism that moves at least one of these components relative to each other in a direction crossing the optical axis of the objective lens; a position detecting unit that obtains relative position information of the stage and the objective lens; an image capturing unit that acquires a partial enlarged image of the sample; a display unit that displays the enlarged image acquired; an image saving unit that saves an enlarged image acquired by the image capturing unit each time at least one of the stage and the objective lens is moved relative to each other by a predetermined distance, based on the relative position information obtained; and an image processing unit that creates a virtual slide by forming an array of saved enlarged images based on the relative position information detected. | 09-15-2011 |
20110221882 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 09-15-2011 |
20110228068 | SYNTHETIC APERTURE OPTICS IMAGING METHOD USING MINIMUM SELECTIVE EXCITATION PATTERNS - A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half-ring shape. | 09-22-2011 |
20110228069 | Technique for estimating cell conditions and image processor for cell observation - Provided is a means whereby the degree of activity of a cell can be determined during cell viewing. By an imaging device, first and second images in which a cell under observation is captured are sequentially obtained at a predetermined time interval, and after aligning the rotational angle orientations on the image plane of the cell under observation that is included in the images, a correlation value or difference of intracellular texture feature values in the first image and second image is sequentially computed. A time series variation of the computed correlation value or difference is then derived, and the degree of activity of the cell under observation is detected based on the state of variation. | 09-22-2011 |
20110228070 | System and Method for Determining Image Focus by Sampling the Image at Multiple Focal Planes Simultaneously - A system and method for maintaining focus in an imaging device; the imaging device having an objective lens with an optical axis, a stage for supporting a specimen, and a controller for controlling the stage-to-objective distance; the system comprising: one or more image sensors placed at a plurality of substantially different axial focal positions, and at least one computing device executing computer-readable instructions stored in its memory and configured to acquire images from each of the image sensors; the method comprising: computing a quantitative image characteristic for each of the images acquired by the computing device, computing an axial stage-to-objective distance correction based on the computed quantitative image characteristics and the plurality of axial focal positions, and causing the controller to adjust the axial stage-to-objective distance according to the computed axial stage-to-objective distance correction. | 09-22-2011 |
20110228071 | Microscope for Forensic Examination - A remote forensic evidentiary item examination system includes a first station and a second station. The first station is locatable at a first location, and is adapted to have a forensic evidentiary item mounted at a fixture thereof. The second station is locatable at a second location different than and remote to the first location, and is in communicative connection with the first station. The second station is adapted to permit a user at the second location to examine the forensic evidentiary item at the first location. | 09-22-2011 |
20110228072 | GENERATION OF A MULTICOLOUR IMAGE OF AN UNSTAINED BIOLOGICAL SPECIMEN - At least two chemically different substances of interest of an unstained biological specimen ( | 09-22-2011 |
20110242307 | TOUCH SCREEN INTERFACE FOR LASER PROCESSING - A touch screen user interface for an optical device wherein the touch screen user interface is connected to a controller which controls motion stages permitting the motion stages to re-position, re-size, re-orient or focus the field of view of the optical device in response to commands input from the touch screen user interface. | 10-06-2011 |
20110242308 | MICROSCOPE AND A FLUORESCENT OBSERVATION METHOD USING THE SAME - A microscope capable of controlling the position and fluorescent recording of an object under observation such as cells is provided with the fluorescent observation method using the microscope. The microscope | 10-06-2011 |
20110249108 | Mask inspection apparatus and mask inspection method - A mask inspection apparatus includes irradiation means for irradiating a sample with an electron beam, electron detection means for detecting a quantity of electrons generated from the sample having a pattern formed thereon by the irradiation with the electron beam, image processing means for generating image data of the pattern on the basis of the quantity of the electrons, and control means for creating a line profile and a differential profile of the pattern formed on the sample on the basis of the quantity of the electrons detected by the electron detection means. The control means detects a rising edge and a falling edge of the pattern on the basis of the differential profile, and then generates mask data of a multi-level structure on the basis of data of the edges and the image data created by the image processing means. | 10-13-2011 |
20110249109 | Microscopy imaging - Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels. | 10-13-2011 |
20110254943 | AUTOMATED ANALYSIS OF IMAGES USING BRIGHT FIELD MICROSCOPY - A system and method for automatically observing and counting cells without using a stain or a fluorescent material. The system includes an optical microscope having a sensor that provides an electrical signal representative of a field of view. The microscope is motorized so as to allow automatic change of focus. A sample containing cells to be analyzed is provided. No stain or fluorescent substance is used. When the microscope is operated in a deliberately out-of-focus condition, cells appear to have either a bright or a dark spot that can be used to report the number of cells in the sample. The intensity variation detected in images acquired in different focal planes is used to identify cell shapes using image analysis software such as CellProfiler. A result is reported in any convenient format, such as a false color image. | 10-20-2011 |
20110261184 | OPTICAL MICROSCOPE METHODS AND APPARATUSES - Embodiments provide microscopes, and more specifically, embodiments provide improvements to zoom control, viewing, and light management in microscopes particularly suited for surgery. These improvements include a compact zoom control system that provides enhanced surgical workspace, ergonomics, and optics, as well as improved methods for controlling a stereomicroscope light source and a novel auxiliary viewing system. | 10-27-2011 |
20110267448 | MICROSCOPY - According to one aspect, the present invention relates to an imaging system ( | 11-03-2011 |
20110267449 | MICROSCOPE SYSTEM, STORAGE MEDIUM STORING CONTROL PROGRAM, AND CONTROL METHOD - A microscope system improves the operability of a user in performing a microscope observation. The microscope system attains the improvement by including: a microscope apparatus including a plurality of drive units; a display unit for displaying an operation screen for operation of the microscope apparatus; a pointing device for inputting by a pointer an operation instruction to the microscope apparatus on the operation screen; and a control unit for switching the drive units depending on the position of the pointer on the operation screen, and controlling the operation of the switched drive units depending on the operation of the pointing device. | 11-03-2011 |
20110285837 | METHODS AND SYSTEMS FOR IDENTIFYING WELL WALL BOUNDARIES OF MICROPLATES - The present invention is directed to method and system for image processing of test wells on a microplates wherein the microplates' test well wall boundaries are identified through the use of a candidate edge image wherein the candidate edge image represents locations of one or more segments of the wall boundaries. | 11-24-2011 |
20110285838 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, IMAGING APPARATUS, AND IMAGING APPARATUS EQUIPPED WITH OPTICAL MICROSCOPE - Provided is an information processing apparatus including a first setting unit and a second setting unit. The first setting unit sets position coordinates of first photography regions arranged along a first direction of two orthogonal axial directions so that the first photography regions adjacent to each other have first overlapping regions where the first photography regions overlap with each other in the first direction. The second setting unit sets position coordinates of second photography regions arranged along the first direction based on the position coordinates of the first photography regions so that the second photography regions adjacent to each other have second overlapping regions where the second photography regions overlap with each other in the first direction, the second photography regions overlap with the first photography regions in a second direction of the two axial directions, and the second overlapping regions are prevented from overlapping with the first overlapping regions. | 11-24-2011 |
20110292198 | MICROSCOPE ACCESSORY FOR ATTACHMENT TO MOBILE PHONE - A microscope accessory for attachment to a mobile phone having a display positioned in a first face and a camera positioned in an opposite second face. The microscope accessory includes: engagement features for releasably attaching the microscope accessory to the mobile phone; and an optical assembly having: a first mirror positioned to be offset from the camera; a second mirror positioned for alignment with the camera; and a microscope lens positioned in the optical path. The optical assembly is matched with the camera, such that a surface is in focus when the mobile phone lies flat against the surface. | 12-01-2011 |
20110292199 | HANDHELD DISPLAY DEVICE WITH MICROSCOPE OPTICS - A handheld display device having a substantially planar configuration. The device includes: a housing having first and second opposite faces; a display screen disposed in the first face; a camera having an image sensor positioned for receiving images from the second face; a window defined in the second face, the window being offset from the image sensor; and microscope optics defining an optical path between the window and the image sensor. The microscope optics are configured for magnifying a portion of a surface upon which the device is resting. A majority of the optical path is parallel with a plane of the device. | 12-01-2011 |
20110292200 | SCANNING MICROSCOPE - A scanning microscope ( | 12-01-2011 |
20110298914 | MICROSCOPE SYSTEM - A microscope system is constructed by a light guiding optical system | 12-08-2011 |
20110304722 | Analyser for Optical Analysis Of a Biological Specimen - An analyser is disclosed for optical analysis of a biological specimen. In at least one embodiment, the analyzer includes optics which includes a camera, intermediate optics and front optics. The intermediate optics is movably arranged and the front optics is fixedly arranged. An analyser for optical analysis of a biological specimen, in at least one embodiment includes a robot for transporting a slide to be analysed. The robot is controlled by at least three motors to allow movement of the robot in three dimensions. The robot includes a handling device configured to grip the slide. | 12-15-2011 |
20110304723 | BESSEL BEAM PLANE ILLUMINATION MICROSCOPE - A microscope has a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a Bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beam and for imaging the received light on a detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction. A detector is configured for detecting signal light received by the imaging optics, and an aperture mask is positioned | 12-15-2011 |
20110310239 | IMAGE PICK-UP APPARATUS - An image pick-up apparatus includes: a color imager having a color filter formed on a light receiving surface thereof; a monochrome imager not having a color filter formed on a light receiving surface thereof; a light guiding unit for guiding, to the color imager and/or the monochrome imager, light originating from a subject; and an image formation unit for forming an image from a signal based on an output from the color imager and/or the monochrome imager. | 12-22-2011 |
20110316998 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, AND PROGRAM - An image processing apparatus includes an interface connected to a microscope having a stage having a placement surface on which a sample including a target is placed, an objective lens that zooms in an image of the sample, and an image pickup element that forms the image of the sample, a controller, and a memory. The controller causes a focus of the objective lens to shift in a vertical direction to the placement surface, and causes the image pickup element to be exposed, thereby obtaining a first image. The controller performs a uniform shift of the focus in the vertical direction and a uniform linear shift thereof in a parallel direction to the placement surface, and causes the image pickup element to be exposed, thereby obtaining a second image. The controller calculates a position of the target in the vertical direction based on the first and second images. | 12-29-2011 |
20110316999 | Microscope apparatus and image acquisition method - Provided is a microscope apparatus including a macro-image, acquisition section that acquires a macro image of a glass slide having a specimen mounted thereon; an extraction section that extracts the specimen in the acquired macro image; a block setting section that sets, when the extracted specimen is scattered to form a plurality of lumps, a plurality of blocks that include the lumps of the specimen; an area dividing section that divides an area that includes the specimen in each of the blocks into a plurality of small regions; and a micro-image acquisition section that acquires, for each of the small regions, a micro image while performing an automatic focusing operation for the specimen in the small region, in which the micro-image acquisition section searches for an autofocusing in-focus position in each of the blocks set by the block setting section. | 12-29-2011 |
20110317000 | METHOD AND SYSTEM FOR ENHANCING MICROSCOPY IMAGE - A microscopy image, formed by illuminating a sample by shining light onto it in an illumination direction and capturing scattered light, is used to produce an enhanced image. This is done using an expression which links the intensity of the portions of the image to respective values of a scattering parameter at multiple respective elements of the sample. The scattering parameter may be an emission coefficient ρ | 12-29-2011 |
20120002029 | SYSTEM AND METHOD FOR SWEEPING MIRROR ENHANCED IMAGING FLOW CYTOMETRY - An imaging flow cytometry system and method which includes a flow chamber, tracking mirror, microscope and imaging optics, image capturing system, device to regulate fluid flow through the chamber, and backlighting generator. The tracking mirror moves at a rate matched to the particle velocity in the flow chamber so as to enhance the sample flow rates possible with the system while maintaining clear and accurate imaging. The backlighting generator passes through the flow chamber and the objective before being focused on the image capturing system. Detected scatter events initiate tracking by the mirror, resulting in imaging with reduced motion blur even at high rates of flow. | 01-05-2012 |
20120002030 | MICROSCOPE AND METHOD FOR THE MICROSCOPIC DETECTION OF LIGHT OF A SAMPLE - A microscope or use of a microscope with at least one illumination beam that is phase-modulated along its cross section partially with a modulation frequency, in which an advantageously local excitation of a transition, advantageously a fluorescence excitation in a sample, is performed by means of a pump beam of a first wavelength and the transition is induced and detected advantageously by means of a second beam, advantageously of a second wavelength, or a local heating is generated that is read out from the detection signals by means of a detection unit, advantageously an infrared camera. | 01-05-2012 |
20120002031 | Imaging Arrangement and Microscope - An embodiment of the present invention is an imaging arrangement that includes imaging optics, a fiducial light source, and a control system. In operation, the imaging optics separate light into first and second tight by wavelength and project the first and second light onto first and second areas within first and second detector regions, respectively. The imaging optics separate fiducial light from the fiducial light source into first and second fiducial light and project the first and second fiducial light onto third and fourth areas within the first and second detector regions, respectively. The control system adjusts alignment of the imaging optics so that the first and second fiducial light projected onto the first and second detector regions maintain relatively constant positions within the first and second detector regions, respectively. Another embodiment of the present invention is a microscope that includes the imaging arrangement. | 01-05-2012 |
20120002032 | INFORMATION PROCESSING APPARATUS, STAGE-UNDULATION CORRECTING METHOD, PROGRAM THEREFOR - Provided is an information processing apparatus including: a connection connecting to a microscope including a stage having a disposition surface on which a target object can be placed, and an image picking-up section including an objective lens for picking up an image of the object, the microscope being movable in first and second axis directions orthogonal to an optical axis of the objective lens and orthogonal to each other and in a third axis direction along the optical axis; a calculator calculating, as an undulation-correcting value, a value for correcting a misalignment of a position in the third axis direction for each predetermined image-capturing range smaller than the disposition surface; a correcting-value storage storing the calculated value; and a corrector correcting a relative distance between the stage and the objective lens on the basis of the stored value for each image-capturing range. | 01-05-2012 |
20120002033 | MICROSCOPE CONTROL DEVICE, IMAGE MANAGEMENT SERVER, IMAGE PROCESSING METHOD, PROGRAM, AND IMAGE MANAGEMENT SYSTEM - A microscope control device includes a driving control unit that controls driving of a microscope which captures a digital enlarged image of a predetermined sample and outputs the corresponding digital enlarged image to an external server, a digital work processing unit that performs a digital work process for the captured digital enlarged image, a load calculation unit that calculates a load which is necessary for the capturing process of the digital enlarged image, and a digital work determination unit that determines whether or not the predetermined digital work process is to be performed by the digital work processing unit based on a load value calculated by the load calculation unit and a load value for the corresponding server obtained from the server. | 01-05-2012 |
20120002034 | MICROSCOPE AND AREA DETERMINATION METHOD - Provided is a microscope including: dark field illumination and bright field illumination which illuminate a preparat where a sample mounted on a slide glass is covered with a cover glass and a mounting agent; an image capturing unit which acquires a dark field image by image-capturing the preparat illuminated by the dark field illumination and which acquires a bright field image by image-capturing the preparat illuminated by the bright field illumination; and a magnified portion image acquisition area determination unit which detects an edge of the cover glass in the preparat based on the dark field image and the bright field image acquired by the image capturing unit and determines an internal area of the detected edge of the cover glass as a magnified portion image acquisition area of the sample. | 01-05-2012 |
20120007977 | MICROSCOPE CONTROL DEVICE, IMAGE DISPLAY DEVICE, IMAGE MANAGEMENT SERVER, IN-FOCUS POSITION INFORMATION GENERATING METHOD, IMAGE DISPLAY METHOD, IMAGE MANAGEMENT METHOD AND MICROSCOPE IMAGE MANAGEMENT SYSTEM - In one example embodiment, a microscope control device a controller configured to store a plurality of images having different depth positions. In one example embodiment, the microscope control device divides the plurality of images into a plurality of sub-regions. In one example embodiment, the microscope control device, for each sub-region, generates in-focus position information which corresponds to a depth position. | 01-12-2012 |
20120013726 | Microscope Illumination Source - A microscope illumination system for photographing in color a specimen as seen through a microscope's eyepieces, using either a black-and-white digital camera or a color digital camera, with the color of the specimen in the resulting photograph matching the color of the specimen as seen through the microscope's eyepieces. | 01-19-2012 |
20120013727 | CELL CHARACTERIZATION USING MULTIPLE FOCUS PLANES - A system for characterizing cells takes a series of digital images of a sample containing the cells. Each of the images is taken at a different plane of focus. One of the images is determined to have been taken at a plane of best focus. The system analyzes the digital image taken at the plane of best focus and at least one other of the digital images to classify cells in the sample as either live or dead. | 01-19-2012 |
20120013728 | CELL OBSERVATION APPARATUS AND OBSERVATION METHOD - Provided is a cell observation apparatus and an observation method with which only an observation target cell in an region of interest is illuminated with illuminating light to prevent photobleaching of cells that are not the observation target. The invention employs a cell observation apparatus including an objective lens that illuminates a specimen with illuminating light, a scanner that adjusts an area illuminated with illuminating light by the objective lens, an image generating portion | 01-19-2012 |
20120019647 | METHOD AND CONFIGURATION FOR THE OPTICAL DETECTION OF AN ILLUMINATED SPECIMEN - A method and a configuration for the depth-resolved optical detection of a specimen, in which a specimen or a part of the specimen is scanned by means of preferably linear illumination. The illumination of the specimen is periodically structured in the focus in at least one spatial direction. Light coming from the specimen is detected and images of the specimen are generated. At least one optical sectional image and/or one image with enhanced resolution is calculated through the specimen. Images are repeatedly acquired and sectional images are repeatedly blended while changing the orientation of the linear illumination relative to the specimen and/or spatial intervals between lines exposed to detection light from the illuminated specimen region are generated for the line-by-line non-descanned detection on an area detector or a camera and/or, during a scan, light is further deflected upstream of the detector through the line in the direction of the scan of the specimen. | 01-26-2012 |
20120026311 | STRUCTURED ILLUMINATION MICROSCOPE APPARATUS AND AN IMAGE FORMING APPARATUS - Polarized light which is emitted from an optical fiber becomes circular polarized light bypassing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light. | 02-02-2012 |
20120026312 | Image Stabilization and Capture Device for an Image Capture System of a Surgical Microscope - The present invention relates to an image stabilization device which is particularly space-efficient and has a quick response time, and which is integrated into an image capture device for an image capture system of a surgical microscope, including a carrier substrate ( | 02-02-2012 |
20120026313 | HOLOGRAPHIC MICROSCOPE - A holography attachment device for a digital imaging device. The holography attachment device including a chamber having a proximate end configured to attach to the digital imaging device. A distal end of the chamber includes a wall. Also, the chamber includes a sample holder section located between the proximate end and the distal end. The sample holder section is configured to receive a sample. The chamber is configured to attach to the digital imaging device. | 02-02-2012 |
20120033064 | MICROSCOPE SYSTEM, SPECIMEN OBSERVING METHOD, AND COMPUTER-READABLE RECORDING MEDIUM - A microscope system includes a pigment amount calculating unit, a cell component identification processing unit, a target molecule expression portion extraction unit, a cell variant setting unit, a cell variant classification determining unit, and a display image generating unit. The pigment amount calculating unit calculates a pigment amount of a molecule target pigment for each pixel of a VS image. The cell component identification processing unit identifies a cell component based on the pigment amount. The target molecule expression portion extraction unit extracts expression portions of target molecules in the area of the cell component. The cell variant setting unit sets a cell variant including a combination of presence/absence of expressions of target molecules. The cell variant classification determining unit classifies a cell area in the VS image into a cell variant based on the combination of the expression portions of the target molecules included in the cell area. | 02-09-2012 |
20120044339 | OPTO-FLUIDIC MICROSCOPE SYSTEM WITH EVALUATION CHAMBERS - An image sensor integrated circuit may contain image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. The image sensor pixels may form light sensors and imagers. The imagers may gather images of the cells or other particles as the fluid passes over the imagers. The channel may have multiple branches. Gating structures and other fluid control structures may control the flow of fluid through the channel branches. Portions of the channel may be used to form chambers. The chambers may each be provided with one or more light sensors, light sources, and color filters to alter the color of illumination form a light source, one or more reactants such as dyes, antigens, and antibodies, and heaters. The branches may route the fluid to respective chambers each of which has a different set of capabilities. | 02-23-2012 |
20120044340 | MICROSCOPE CONTROL DEVICE AND OPTICAL DISTORTION CORRECTION METHOD - A microscope control device includes an offset processing unit that corrects phase contrast information regarding a phase contrast between corresponding phase contrast images, which is generated based on a set of the phase contrast images of a sample which are captured by a microscope, based on offset information of phase contrasts caused by optical distortions unique to the microscope, and a defocus amount calculation unit that calculates a defocus amount of the sample on the basis of the phase contrast information after offset correction. | 02-23-2012 |
20120044341 | OPTOFLUIDIC MICROSCOPE SYSTEM-ON-CHIP - An integrated circuit may contain image sensor pixels. Channels containing a fluid with samples such as cells may be formed on top of the image sensor. Control circuitry may be formed on the integrated circuit. The image sensor pixels may form light sensors and imagers. Portions of the channel may have multiple chambers such as fluorescence detection chambers. Gating structures and other fluid control structures may control the flow of fluid through the channels and chambers. Portions of the channel may be used to form chambers. The chambers may each be provided with one or more light sensors, light sources, and color filters to alter the color of illumination form a light source, one or more reactants such as dyes, antigens, and antibodies, and heaters. The control circuitry may be configured to control the imagers, the gating structures, the fluid control structures, the light source, the heaters, etc. | 02-23-2012 |
20120044342 | DIGITAL MICROSCOPE - A method including sensing an image without magnification of a portion of a tissue sample on a substrate with a sensor; displaying the sensed image on a display at a sensor to display pixel ratio greater than one to one; and performing at least one of the following: refreshing the sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. An apparatus comprising a digital microscope comprising: at least one image sensor; a stage configured to support at least one microscope slide; a first optic configured to project an image with a magnification of one or less; a second optic disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a light source; and a computer coupled to the digital microscope and operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic | 02-23-2012 |
20120057014 | IMAGING APPARATUS - A plurality of image sensors are arranged so that each of odd rows is constituted by image sensors lined up in the X direction, and each of even rows is constituted by image sensors, more than that of the odd row by 1, lined up in the X direction at the same pitch as the odd row with a 1/2 phase shift with respect to the odd row. Light receiving areas of image sensors on both ends of the even row include both ends in the X direction of an imaging target area image respectively, and a length in the Y direction of an area covering the light receiving areas of the image sensors on the first row to the light receiving areas of the image sensors on the last row is longer than a length in the Y direction of the imaging target area image. | 03-08-2012 |
20120062721 | DIGITAL MICROSCOPE WITH COAXIAL LIGHT OUTPUT - A digital microscope is disclosed including: an image sensing circuit having an image sensing area thereon; a first object lens aligned with the image sensing area along an axis; a luminance device positioned outside the axis for emitting light toward a direction that is not coaxial with the axis; a light redirector positioned outside the axis for redirecting the light emitted from the luminance device; and a beam splitter positioned on the axis for changing the direction of light from the light redirector to provide an output light that is outputted substantially along the axis and coaxial with the axis; wherein the first object lens is positioned between the image sensing area and the beam splitter. | 03-15-2012 |
20120062722 | MICROSCOPE APPARATUS AND OBSERVATION METHOD - A microscope apparatus comprises: a distribution measurement apparatus with respect to an observation region that comprises a fluorescent material that is activated when irradiated with an activating light, and that emits fluorescence when irradiated with an exciting light of a wavelength different from the activating light, obtains a fluorescent picture image through irradiation with the exciting light, and measures a fluorescent intensity distribution; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by repeating an operation wherein the observation region is irradiated with the activating light at the set irradiation intensities, and repeating an operation wherein a fluorescent picture image is obtained by irradiating with the exciting light after the activating light irradiation, generating a sample picture image. | 03-15-2012 |
20120062723 | MICROSCOPY IMAGING DEVICE WITH ADVANCED IMAGING PROPERTIES - Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm | 03-15-2012 |
20120069170 | SYSTEM FOR IMAGE RENDERING OR SPECTRAL RECOGNITION - Embodiments of a method or a system for rendering images or spectral recognition are described. | 03-22-2012 |
20120069171 | IMAGING DEVICE FOR MICROSCOPE - An imaging device including an imaging unit that obtains a video signal; a signal processing unit that processes the video signal; a movement detection unit that calculates a relative moving speed between the imaging unit and a stage in a first direction perpendicular to an optical axis of the imaging unit; a setting unit that determines a parameter such that time required for the signal processing is reduced where the relative moving speed is more than or equal to a threshold value; and, a frame rate conversion unit that selects between a process of increasing a frame rate of the video signal subjected to the signal processing where the relative moving speed is more than or equal to the threshold value, and a process of maintaining a current frame rate, to apply the selected process, wherein the signal processing unit applies the signal processing in accordance with the parameter. | 03-22-2012 |
20120075453 | Method for Detecting and Quantitating Multiple-Subcellular Components - A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins. | 03-29-2012 |
20120075454 | ELECTRONIC MAGNIFIER - An electronic magnifier includes a stage on which an object to be read is placed, an imaging unit which is disposed above the stage to image the object, a liquid crystal display (LCD) monitor which is mounted via a pivoting member to the imaging unit so as to be pivotable, wherein the LCD monitor is configured to be accommodated in a space defined between the imaging unit and the stage. | 03-29-2012 |
20120075455 | IMAGING METHOD AND MICROSCOPE DEVICE - An imaging method may include a first step in which light from a test specimen is guided to an imaging unit, a second step in which light from the test specimen is guided to an autofocus unit, a third step in which the light guided to an autofocus unit is split, and is guided on a third optical path and a fourth optical path, a fourth step in which a focal point of the imaging unit is adjusted such that an image of the test specimen that is created by the light from the test specimen guided on the first optical path is formed on an imaging surface of the imaging unit, a fifth step in which an image of the test specimen is acquired and image data is created, a sixth step in which spectrum information for the test specimen is detected, and a seventh step in which a color tone of the image data is corrected. | 03-29-2012 |
20120075456 | METHOD FOR CHARACTERIZING A FEATURE ON A MASK AND DEVICE FOR CARRYING OUT THE METHOD - A mask inspection microscope is provided for characterizing a mask having a feature. The mask inspection microscope is configured to generate an aerial image of at least one segment of the feature of the mask, acquire a spatially resolved intensity distribution of the aerial image, and determine a total intensity from the intensities of at least one region of the aerial image. | 03-29-2012 |
20120075457 | Fully Automatic Rapid Microscope Slide Scanner - Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. | 03-29-2012 |
20120081534 | MICROSCOPE SYSTEM AND DATA DISTRIBUTION SYSTEM - A microscope system includes a microscope apparatus, a pigment content converter, a property information adding unit, and a communication unit. The microscope apparatus acquires, by using a microscope, a pathology specimen image of a pathology specimen stained with a predetermined pigment. The pigment content converter converts, by using pigment spectral data, pixel values of the pathology specimen image to the pigment content at corresponding sample points on the pathology specimen. The property information adding unit generates conversion image data by adding the pigment spectral data, which is used for the conversion, to the pigment content of each pixel that is converted by the pigment content converter. The communication unit transmits the conversion image data to a terminal device. | 04-05-2012 |
20120081535 | SAMPLE OBSERVATION DEVICE FOR GENERATING SUPER RESOLUTION IMAGE - A sample observation device includes: an excitation light generation unit; an intermediate image forming unit projecting excitation light to a sample and forming an intermediate image of the sample at an intermediate image position with observing light; a confocal modulation unit modulating spatial intensity distributions of the excitation light and the intermediate image at the position; a modulation drive unit moving a pattern of the modulation unit; an image relay unit relaying on a image forming surface the intermediate image; an image pickup unit converting the distribution of relayed intermediate image into digital image data; and an image processing unit processing on the digital image data. Cutoff frequency of the relay unit and Nyquist frequency of the pickup unit exceed cutoff frequency of the forming unit, and the processing unit performs a high frequency enhancing process for enhancing the high frequency component exceeding the cutoff frequency of the forming unit. | 04-05-2012 |
20120081536 | Microscope System, Microscopy Method and Storage Medium - A microscope system comprises a microscope for data acquisition and a computing device configured to control the microscope during data acquisition and/or to perform data processing of raw data captured by the microscope. The computing device is coupled to an optical output device. The microscope and the computing device are configured to perform the data acquisition and/or data processing based on values that are respectively set for each one of a plurality of adjustable parameters. The computing device selectively outputs graphics data via the optical output device as a function of an adjustable parameter selected from the plurality of adjustable parameters. The output graphics data are assigned to the selected adjustable parameter and represent an affect of the selected adjustable parameter on at least one step of a procedure upon which the data acquisition and/or the data processing is based. | 04-05-2012 |
20120086795 | MICROSCOPE ILLUMINATION SYSTEM, MICROSCOPE AND OBLIQUE INCIDENT ILLUMINATION METHOD - A microscope illumination system includes a first light source configured to provide light along an optical axis and an aperture device including an aperture wheel that is rotatable about an axis of rotation. The aperture wheel includes a plurality of apertures of varying size disposed circumferentially on the aperture wheel. The aperture wheel is rotatable so as to dispose each of the apertures in a position that is centered on the optical axis so as to generate an illumination beam path that extends in a centered relationship with respect to the optical axis, and so as to dispose each of the apertures in a position that is off-center from the optical axis and that is within a defined region around the optical axis so as to generate an illumination beam path that extends off-center from the optical axis for oblique incident illumination. | 04-12-2012 |
20120092476 | METHODS AND APPARATUS TO FORM A WAVELET REPRESENTATION OF A PATHOLOGY SLIDE HAVING GLASS AND TISSUE REGIONS - Example methods, apparatus and articles of manufacture to form a wavelet representation of a pathology slide having glass and tissue regions are disclosed. A disclosed example method includes capturing a digital image of a pathology slide, identifying a portion of the digital image that represents a glass portion of the slide, and storing a value representing that the wavelet coefficients for the identified glass portion of the slide are unused without computing a wavelet transform for the identified glass portion. | 04-19-2012 |
20120092477 | WIDE FIELD MICROSCOPIC IMAGING SYSTEM AND METHOD - A wide field microscopic image acquisition apparatus and method are disclosed. The apparatus is configured to acquire images of a specimen on a microscope slide and includes first and second illuminators each having unique illumination characteristics. The apparatus includes a microscope imaging system with an imaging device, an objective lens and a stage configured to digitally acquire a plurality of images of the specimen using the first and second illuminators. A controller is configured to automatically control the microscope imaging system and acquire the plurality of images of the specimen using the first and second illuminators. The first and second illuminators can be bright field, dark field or fluorescent illuminators. | 04-19-2012 |
20120092478 | INCUBATED STATE EVALUATING DEVICE, INCUBATED STATE EVALUATING METHOD, INCUBATOR, AND PROGRAM - An incubated state evaluating device includes an image reading unit, a feature value calculating unit, a frequency distribution calculating unit, and an evaluation information generating unit. The image reading unit reads a plurality of images in which a plurality of cells incubated in an incubation container are image-captured in time series. The feature value calculating unit obtains each of feature values representing morphological features of cells from the images for each of the cells included in the images. The frequency distribution calculating unit obtains each of frequency distributions of the feature values corresponding to the respective images. The evaluation information generating unit generates evaluation information evaluating an incubated state of cells in the incubation container based on a variation of the frequency distributions between images. | 04-19-2012 |
20120092479 | METHOD AND APPARATUS FOR THE MICROSCOPIC IMAGING OF A SAMPLE STRUCTURE - A method and an apparatus for imaging a sample structure ( | 04-19-2012 |
20120092480 | UNIQUE DIGITAL IMAGING METHOD EMPLOYING KNOWN BACKGROUND - An imaging apparatus includes a specimen placed on a known background of known bit depth values, and an image sensor having a field of view that includes at least a portion of the specimen and a portion of the known background. A sensor controller is included for recording an image of the portion of the specimen and the portion of the known background in the field of view, the apparatus further including means for effecting relative movement between the image sensor and the specimen. | 04-19-2012 |
20120092481 | DIGITAL MICROSCOPE SLIDE SCANNING SYSTEM AND METHODS - Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots. | 04-19-2012 |
20120098949 | SPIM MICROSCOPE WITH A STED LIGHT SHEET - A STED-SPIM-microscope (Selective Plane Imaging Microscopy) having a y-direction illumination light source and a z-direction detection light camera. An x-scanner generates a sequential light sheet by scanning the illumination light beam in the x-direction. By optionally turning on a STED deactivation light beam the light sheet can optionally be made thinner and therefore the optical resolution can be increased. | 04-26-2012 |
20120098950 | SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM - A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest. | 04-26-2012 |
20120098951 | DEVICE FOR FORMING A HIGH-RESOLUTION IMAGE, IMAGING SYSTEM, AND METHOD FOR DERIVING A HIGH-SPATIAL-RESOLUTION IMAGE - A device for forming a high-resolution image of an object is provided. The device comprises: an electronic camera for capturing an intermediate image of the object, an illumination system for forming a spatial modulation pattern on the object; and a spatial demodulator for performing a spatial demodulation, which is at least partially matched to the spatial modulation pattern. A method for deriving a high-spatial-resolution image from a set of images captured from a structure of an object is derived, wherein the illumination of the object is spatially-modulated, wherein the illumination of the object has a spatial modulation pattern, which is substantially periodic, wherein one of at least one prevailing orientation of the periodic illumination is arranged substantially perpendicularly to at least one prevailing orientation of the structure of the object. | 04-26-2012 |
20120098952 | CHARGED-PARTICLE MICROSCOPE DEVICE AND METHOD FOR INSPECTING SAMPLE USING SAME - A high-performance image quality improvement process, capable of improving the image quality of low-definition areas (lower layer patterns in a multilayer, bottoms of holes in a hole pattern, etc.), is performed to a captured image. Definition enhancement intensity is calculated using height information included in design data or estimate values of sample height information calculated from the captured image, and the image quality improvement process is performed to the captured image using the definition enhancement intensity. | 04-26-2012 |
20120113242 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays. | 05-10-2012 |
20120113243 | INSPECTION SYSTEM - An inspection system for flat objects, especially wafers and dies, comprising: a handling system for loading objects into the inspection system; a sensor assembly for receiving images or measuring values of the object surface or parts of the object surface; a driving assembly for generating a relative movement between the objects and the sensor assembly, where a movement is effected between objects relative to the sensor assembly along a first trajectory; wherein at least one further sensor assembly is provided, and the driving assembly is adapted to generate a further relative movement, where a movement of different objects relative to the sensor assembly can be generated on at least a second trajectory in order to allow at least two objects to be treated simultaneously. | 05-10-2012 |
20120120222 | OPERATOR CONTROL UNIT FOR A MICROSCOPE - An operator control unit for use with a microscope is configured for at least one of selecting and adjusting at least one electrically controllable function of the microscope. The operator control unit is portable with one hand and includes a handle portion and at least one sensor configured to receive user control commands so as to at least one of activate, deactivate and adjust the at least one electrically controllable function. The at least one sensor includes a touch sensor and is disposed so as to accommodate holding and operation of the operator control unit simultaneously with one hand. The at least one sensor is disposed symmetrically with respect to the handle portion. The at least one sensor is assignable to different changeable microscope functions by actuation of at least one of the control unit and the at least one sensor. | 05-17-2012 |
20120120223 | PORTABLE MICROSCOPE - A portable microscope includes an integrated operator control unit configured for at least one of selecting and adjusting at least one electrically controllable function of the microscope. The operator control unit includes at least one sensor configured to receive user control commands for at least one of activation, deactivation and adjustment of the at least one electrically controllable function. The at least one sensor includes a touch sensor and is disposed so as to accommodate holding and operation of the microscope with a single hand of a user. | 05-17-2012 |
20120120224 | MICROSCOPE HAVING A TOUCH SCREEN - A microscope includes an image acquisition system, microscope components and a touch screen. The image acquisition system is configured to optically and digitally image an object so as to produce an object image The microscope components are at least one of motorized and electrically controllable. The touch screen is configured to display the object image in a display area thereof and to sense inputs in the display area within the displayed object image so as to change settings of the microscope components. | 05-17-2012 |
20120120225 | MICROSCOPE SYSTEM AND METHOD - A method for determining a position of an area of an object within the complete object, wherein the image of the area of the object is contained within a field of view of a microscope. The method comprises acquiring high magnification image data representing an image of the field of view of the microscope, typically from a digital camera attached to the microscope; processing the high magnification image data to reduce the resolution thereof; comparing the processed high magnification image data with portions of the low magnification image data, and determining said position based on the results of said comparison. | 05-17-2012 |
20120127297 | DIGITAL MICROSCOPY WITH FOCUS GRADING IN ZONES DISTINGUISHED FOR COMPARABLE IMAGE STRUCTURES - Digital image quality is assessed, especially focus accuracy for a microscopic pathology sample image, using quality assessment criteria that differ among zones distinguished by a structural classification process. An image or area is divided into sub-regions such as adjacent pixel blocks. At least one metric or algorithm is applied, such as a Brenner gradient correlated with focus quality or a Laplacian transform correlated with structural difference. Spatial zones are distinguished by associating blocks of pixels that produced comparable values from the metric. The quality results of an objective metric such as the Brenner gradient are graded separately using statistical or pass/fail grading criteria in each spatial zone, independent of other zones. Focus quality across the image is mapped for display and/or used to queue a re-imaging step. | 05-24-2012 |
20120127298 | SYSTEM AND METHOD FOR MONITORING BIREFRINGENT PARTICLES IN A FLUID - An imaging system with an imaging mechanism which includes polarization analyzers, which may be crossed polarization analyzers, positioned to provide birefringence images of particles in the fluid passing through the flow chamber. Captured images are of high resolution and may be used in comparison to known images of a library of images. The system and related method enhance the accuracy and sensitivity of particle monitoring by utilizing birefringence imaging combined with particle analysis and the detection of each particle's characteristic features, such as crystalline features. The system includes a scatter detector used to trigger backlighting of the flow chamber and capture images of particles therein. | 05-24-2012 |
20120133755 | ORGANISM SAMPLE OBSERVATION DEVICE - A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen. | 05-31-2012 |
20120133756 | COMPACT, HIGH-RESOLUTION FLUORESCENCE AND BRIGHTFIELD MICROSCOPE AND METHODS OF USE - The present invention provides a compact, inexpensive fluorescence microscope capable of high-resolution imaging with high light throughput suitable for use in both laboratory and field environments, and methods of use. A simple and inexpensive fluorescence microscope allows health care workers to perform various medical assays at the point of care instead of having to collect and transport biological samples to distant labs, and subsequently return the results to the patient. The microscope of the present invention is also useful for educational use and field use, and other uses as well. | 05-31-2012 |
20120140055 | MICROSCOPE, REGION DETERMINING METHOD, AND PROGRAM - A microscope includes a dark-field illumination system that irradiates dark-field illumination light to a preparation in which a specimen is encapsulated between slide glass and cover glass by using an encapsulant, and an imaging unit that takes a dark-field image of the preparation irradiated with the dark-field illumination light. The microscope further includes a region determiner that detects the boundary between the encapsulant and air included between the slide glass and the cover glass based on the taken dark-field image and determines a region other than a region of the air as a region of interest for the specimen. | 06-07-2012 |
20120140056 | SAMPLE IMAGING SYSTEM AND METHOD FOR TRANSMITTING AN IMAGE OF CELLS OR TISSUES LOCATED IN A CULTURING SPACE TO DATA PRCESSING MEANS - The invention relates to a sample imaging system ( | 06-07-2012 |
20120140057 | Microscope for Measuring Total Reflection Fluorescence - Currently, relatively weak light sources with low light intensities are used in wide-field microscopes. Inevitably, focusing in the pupil plane thereby results in low light intensities in the sample, since the output of the light source is distributed over a very large sample area. However, there are also wide-field technologies requiring very high intensities, for example, photo-activates localization (PAL) microscopy. It is the object of the invention to allow, with little expenditure, the flexible adjustment of the illumination light intensity in the sample. For this purpose, a laser ( | 06-07-2012 |
20120147171 | METHOD FOR MEASURING VIA BOTTOM PROFILE - A method for measuring a via bottom profile is disclosed for obtaining a profile of a bottom of a via in a front side of a substrate. In this method, an infrared (IR) light source is transmitted from the back of the substrate to the bottom of the via through an objective by using an IR-microscope, and lights scattered from the bottom of the via are acquired by an image capturing device to generate an image, where the image displays a diameter ( | 06-14-2012 |
20120147172 | IMAGE PROCESSOR, IMAGE PROCESSING METHOD, PROGRAM AND MICROSCOPE - An image processor, a program and a microscope enable a TIRF image and a confocal image to be superposed simply and accurately. A reference point detection unit | 06-14-2012 |
20120169862 | Digital Microscope System - Disclosed is a digital microscope system capable of controlling two or more microscope units with a controlling unit. The digital microscope system includes (i) two or more microscope units, (ii) a camera interface, (iii) a controlling unit and (iv) a light output device. The microscope unit includes a lens tube, a digital camera, a light terminator and a stand. The camera interface includes two or more camera interface (I/F) channels and a camera interface channel selector. The controlling unit includes a memory, a display device, a CPU (Central Processing Unit) and a power supply. | 07-05-2012 |
20120169863 | APPARATUS AND METHOD FOR AUTOMATIC DETECTION OF PATHOGENS - The invention discloses an apparatus and method for automatic detection of pathogens within a sample. The apparatus and method are especially useful for high-throughput and/or low-cost detection of parasites with minimal need for trained personnel. The invention entails automated microscopic data acquisition, and performing image processing of images captured from a sample using classification algorithms. Visual classification features of structures are extracted from the image and compared to visual classification features associated with known pathogens. A determination is reached whether a pathogen is present in the sample; and if present, the pathogen may be identified to a pathogen species. Diagnosis is rapid and does not require medically trained personnel. | 07-05-2012 |
20120169864 | Method for Correcting Image Distortions in a Confocal Scanning Microscope - In order to identify scan coordinate values (φ | 07-05-2012 |
20120176487 | METHODS AND SYSTEM FOR VALIDATING SAMPLE IMAGES FOR QUANTITATIVE IMMUNOASSAYS - A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation. Results can be examined at a user interface allowing for user inspection of samples determined to be unsuitable, the user interface also having provisions for manual override of the determination. | 07-12-2012 |
20120182411 | IMAGE-ACQUISITION DEVICE FOR MICROSCOPE AND MICROSCOPE OBSERVATION METHOD - Proper exposure is achieved within a short period of time even when image-acquisition elements are switched. Provided is an image-acquisition device for a microscope, which includes an optical-path branching section that branches light from an object into two optical paths; a first image-acquisition element and a second image-acquisition element that are respectively disposed in the two optical paths branching from the optical-path branching section and that acquire images of the light from the object under different image-acquisition conditions; and an exposure-time calculator that calculates an exposure time for the second image-acquisition element on the basis of an exposure time for the first image-acquisition element and a ratio of the image-acquisition conditions of the first and second image-acquisition elements. | 07-19-2012 |
20120182412 | Inspection Instrument - The present disclosure relates an inspection instrument adapted to increase testing throughput in a manufacturing process. In one embodiment, the inspection instrument includes a base plate and a vertical frame, where the base plate and the vertical frame are configured to provide structural support of the inspection instrument, a first mounting mechanism coupled to the base plate, where the first mounting mechanism is configured to hold a sample for inspection, and a second mounting mechanism coupled to the vertical frame, where the second mounting mechanism is configured to hold a set of sensors and an optical system for inspecting the sample. The first mounting mechanism and the second mounting mechanism are decoupled from each other to reduce impact of movements of the sample to the set of sensors and the optical system. | 07-19-2012 |
20120182413 | PLANE-PROJECTION MULTI-PHOTON MICROSCOPY - A novel method and system for conducting wide-field multi-photon microscopy through plane-projection are provided. It has been discovered that the limitations of conventional temporal-focusing techniques, such as single excitation wavelength and low acquisition rates can be resolved utilizing a novel optical set-up in which an optical diffuser is used as the scatterer. The use of such an optical arrangement enables temporal focusing regardless of the central wavelength of laser pukes. In addition, the optical sectioning possible using the disclosed microscopy is comparable to confocal microscopy, and can be robustly achieved by both moderate and high NA objectives at 100-fs puke width. Moreover, the multi-photon excitation efficiency of the disclosed system can be enhanced by lowering the repetition rate of the ultrafast laser light source at constant pulse width and average power. | 07-19-2012 |
20120182414 | CATADIOPTRIC OPTICAL SYSTEM AND IMAGE-PICKUP APPARATUS HAVING THE SAME - A catadioptric optical system includes a first imaging optical system including a catadioptric part configured to condense a light flux from an object and to form an intermediate image of the object, and a second imaging optical system including a dioptric part configured to form an image of the intermediate image on an image surface. The light flux from the object passes through the light transmission part of the first optical element, the negative lens, the backside reflection part of the second optical element, the negative lens, the backside reflection part of the first optical element, the negative lens, and the light transmission part of the second optical element, in this order, and is emitted to the second imaging optical system. An Abbe number of a material of the negative lens is larger than that of a material of the second optical element. | 07-19-2012 |
20120188358 | OPTICAL APPARATUS - An optical system capable of obtaining a high-resolution image using interference and thus capable of providing a stable signal is realized. A particular polarization state of response light emitted from an object is selected, and light in the selected particular polarization state is split into two beams. The split two beams are polarized into two different polarization states. After one of the two beams is subjected to an image inversion, the two beams are condensed such that they interfere with each other. The interfering light is split into a plurality of beams, and each of these beams is detected after they are passed through different polarizing filters. Detected signals are combined together and processed to obtain high-stability amplitude information without being influenced by a phase difference between the two beams. | 07-26-2012 |
20120188359 | Microscope System, Focus Position Detection Method, And Focus Position Detection Program - To provide a microscope system capable of automatically detecting a position of a focus of an optical system relative to an observing object. A light emitted from a laser light source is irradiated on an observing object, and the light reflected by the observing object is guided to a light receiving element. An evaluation value based on a plurality of pixel data is set so as to be smaller than an output upper limit value Emax and greater than a multiplication value En | 07-26-2012 |
20120188360 | Microscope System, Surface State Observing Method, And Surface State Observing Program - To provide a microscope system enabling the user to accurately observe the surface of the observing target in a short time. A sensitivity parameter for adjusting a value of the pixel data corresponding to a plurality of pixels is set. The pixel data is acquired with a first sensitivity value set as the sensitivity parameter, and the number of pixels in which the peak value of the pixel data is smaller than or equal to a threshold value is detected. A ratio of the detected number of pixels with respect to the total number of pixels region is calculated, where the pixel data is acquired by a second sensitivity value different from the first sensitivity value when the ratio is greater than or equal to a reference value, and the pixel data is not acquired by the second sensitivity value when the ratio is smaller than the reference value. | 07-26-2012 |
20120194664 | CELL PICKING-ASSISTING DEVICE, DISPLAY DEVICE AND CULTURE CONTAINER - A cell picking support device, a display device and a culture container that can enhance work efficiency. An adapter fixes a well plate that holds cells cultured in a cell culture observation device. A control unit reads culture observation information that includes cell information and coordinate information, from a memory card that is fitted to an external memory I/F. A display unit is provided on a placing surface side of the well plate that is fixed by the adapter, and in response to control by the control unit, displays the cell information, read from the memory card, at display positions corresponding to positions on the bottom face of the well plate, as specified by the coordinate information. Embodiments can be used, for instance, as a cell picking support device that supports a picking operation that is performed in a clean bench. | 08-02-2012 |
20120200691 | MICROSCOPE APPARATUS AND CONTROL METHOD - A microscope apparatus and control method. An image processing unit obtains an image on a plane observation cross-section inside a sample. A drive control unit controls a galvano-scanner and a z drive unit, and inclines the entire observation cross-section in a direction where the cross-section of an observation target that appears in the image becomes long. When an edge portion of the cross-section of the observation target is detected in the observation cross-section while gradually inclining the observation cross-section, the drive control unit uses an axis passing through the edge portion as the center to incline a part of the observation cross-section located on a side, where the cross-section of the observation target does not appear, from among the sides having this axis as a boundary, in a direction where the cross-section of the observation target appears, so as to form the observation cross-section having a profile which is folded. | 08-09-2012 |
20120200692 | METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT - A method and associated system for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays. | 08-09-2012 |
20120200693 | MICROSCOPE WITH A SHEET OF LIGHT - A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region. | 08-09-2012 |
20120200694 | MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE - Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry. | 08-09-2012 |
20120206589 | System and Method for Single Optical Axis Multi-Detector Microscope Slide Scanner - Systems and methods for microscope slide scanning using multiple sensor arrays that receive imagery data from a single optical axis are provided. A single, high quality, easily obtained microscope objective lens is used to project an image onto two or more sensor arrays. The sensor arrays can be linear or two dimensional and imaging takes place along a single optical axis. Simultaneous sensor acquisition and parallel data processing reduce the image acquisition time by a factor of N, where N represents the number of sensors employed. | 08-16-2012 |
20120206590 | FOCUSING DEVICE, FOCUSING METHOD, FOCUSING PROGRAM AND MICROSCOPE - In one example embodiment, a focusing device generates a first image associated with a sample having a first irregularity. The focusing device determines a second irregularity based on the generated first image. In this embodiment, the determined second irregularity corresponds to the first irregularity. For a lens, the focusing device determines a focusing position based on the determined second irregularity. | 08-16-2012 |
20120212599 | IMAGING APPARATUS AND IMAGING METHOD - An imaging method includes: a preliminary measurement step of imaging an object on a stage with an imaging unit; a determination step of determining the number of images to be captured of the object by analyzing the image data obtained in the preliminary measurement step; and a main measurement step of performing, according to the number of images to be captured determined in the determination step, either first processing for acquiring image data of a single image by imaging the object on the stage, or second processing for acquiring image data of a plurality of images with different focal positions by imaging the object on the stage for a plurality of times while changing the focal position. | 08-23-2012 |
20120212600 | CATADIOPTRIC OPTICAL SYSTEM AND IMAGE PICKUP APPARATUS HAVING THE SAME - A catadioptric optical system includes a first imaging optical system that includes a catadioptric part that collects a light beam from an object to form an intermediate image of the object, and a second imaging optical system that includes a refractive part that images the intermediate image on an image plane. The first imaging optical system includes a first optical element, a second optical element, and a negative lens in an optical path between the first and second optical elements, and the first and second optical elements are disposed so that reflection parts of the first and second optical element face each other. A power pn of the negative lens, radii of curvature R | 08-23-2012 |
20120218400 | MICROSCOPIC IMAGE PICKUP APPARATUS - A microscopic image pickup apparatus for acquiring images of specimens on slide glass samples includes a slide holder pickup section by which the whole image of a slide holder on which a plurality of slide glass samples are arrayed is acquired, a slide glass sample macro-pickup section by which whole images of the slide glass samples are acquired, a slide glass sample micro-pickup section by which micro images of specimen areas of the slide glass samples are acquired under predetermined imaging conditions, and an imaging process control section generating a slide glass sample information management screen. The slide glass sample information management screen is displayed such that the array of display areas for displaying imaging conditions-setting means for setting imaging conditions and for displaying whole images of slide glass samples is paralleled with the array of slide glass samples on a slide holder. | 08-30-2012 |
20120224044 | Quantitative, Multispectral Image Analysis of Tissue Specimens Stained with Quantum Dots - A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C1 . . . CN at each pixel which are related to the concentration of each of the individual fluorophores. Morphological processing instructions find biological structures. A display module displays quantitative analysis results to the user. The quantitative analysis display includes histograms of the biological structures, scatter plots of fluorophore concentrations, statistical data, spectral data, image data and still others. | 09-06-2012 |
20120236137 | IMAGING APPARATUS - An imaging apparatus includes an imaging optical system configured to form an optical image of an object, a first imaging sensor device, a second imaging sensor device having an integration degree smaller than that of the first imaging sensor, and a controller configured to execute a first imaging mode in which the first imaging sensor device is used for image pickup of the object while the first imaging sensor device is located at an image plane of the imaging optical system, and a second imaging mode in which the second imaging sensor device is used for image pickup of the object while the second imaging sensor device is located at the image plane of the imaging optical system. | 09-20-2012 |
20120249770 | METHOD FOR AUTOMATICALLY FOCUSING A MICROSCOPE ON A PREDETERMINED OBJECT AND MICROSCOPE FOR AUTOMATIC FOCUSING - A method for automatic focusing of a microscope on a predetermined object in a specimen to be examined may include
| 10-04-2012 |
20120249771 | MICROSCOPY SYSTEM, MICROSCOPY METHOD AND METHOD OF TREATING AN ANEURYSM - A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. | 10-04-2012 |
20120257037 | HIGH SPEED MICROSCOPE WITH TWO-STAGE SCANNING FOR DETECTION OF RARITIES IN SAMPLES - A system and method of implementing a two-stage scanning technique with a high-speed microscope. The microscope is operable to provide spectrally resolved, multi-dimensional images from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The sample is first tagged such that, if the sample has a particular makeup, it emits energy at particular wavelengths upon receiving excitation beams. The microscope is used to perform a first, wide area scan. If the sample is determined to have emitted energy having particular characteristics, the microscope performs a second, focused scan of the area that emitted the energy having the particular characteristics. The two-stage scanning technique is automated and may be used to quickly identify rare cells, microbes, viruses, and other components within one or more samples. | 10-11-2012 |
20120257038 | HIGH SPEED MICROSCOPE WITH NARROW DETECTOR AND PIXEL BINNING - A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide spectrally resolved, multi-dimensional images from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The microscope includes a descanning arrangement such that emitted fluorescence is static on a receiving detector. The detector is a narrow detector with a width at least half the size of the length, to reduce the amount of pixel data being transmitted and improve scan speeds. The microscope may also incorporate one or more binning techniques whereby pixels are binned together to improve resolution or scan speeds. | 10-11-2012 |
20120257039 | Image Processing Device, Measuring/Testing System, and Program - The present invention provides a contour extraction technique capable of resolving not only spuriousness, duplication, or branches in the contours of a sample pattern, but also discontinuities in the contours. A thinning process is performed with respect to design data for generating a sample pattern, and pattern in/out definition information defining the inside and outside of a pattern formed on a target sample is generated. Then, based on the Marker Controlled Watershed Segmentation method, region segmentation is performed by expanding regions indicated by the pattern in/out definition information while referencing pixel values of an edge-enhanced image of a target sample image, and pattern contours are generated. | 10-11-2012 |
20120262561 | MICROSCOPE SYSTEM, SERVER, AND PROGRAM - A microscope includes an illuminating optical system that illuminates the test object under predetermined illumination conditions, an imaging optical system that forms an image of the test object, and an image sensor that outputs an image signal. The computer includes an image analyzing unit that acquires an image feature amount of the test object on the basis of the image signal detected by the image sensor, a comparison unit that compares the image feature amount of the test object with image feature amounts of a plurality of sample test objects and specifies an image feature amount of a sample test object closest to the image feature amount of the test object, and a setting unit that sets illumination conditions of the illuminating optical system on the basis of an illumination state suitable for observation of a sample test object having the image feature amount specified by the comparison unit. | 10-18-2012 |
20120262562 | IMAGING APPARATUS AND PROGRAM - An imaging apparatus includes an imaging unit that images a test object, an analysis unit that outputs a feature amount of an image which is captured by the imaging unit, a storage unit that stores an evaluation function which has the image feature amount as a variable, for evaluation of the image, a selection unit that selects one image from two or more images including an image specified based on a value of the evaluation function, and a changing unit that changes the evaluation function based on the one image in a case where the one image selected by the selection unit is different from the specified image. | 10-18-2012 |
20120262563 | METHOD FOR PREPARING QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCIATED SYSTEM - Embodiments of the present invention are directed to a method for calibrating an imaging system for analyzing a plurality of molecular species in a sample. According to one embodiment, the method comprises acquiring a plurality of images of the sample with an image acquisition device at a plurality of different wavelengths, comparing a region of interest associated with at least one of the images acquired at one respective wavelength to a region of interest associated with at least one of the images acquired at a different wavelength, and aligning the plurality of images such that the region of interest associated with at least one of the images acquired at one respective wavelength corresponds to the region of interest associated with the at least one of the images acquired at a different wavelength. | 10-18-2012 |
20120262564 | METHOD FOR OPTIMIZATION OF QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCIATED SYSTEM - Embodiments of the present invention are directed to a method for determining an amount of a plurality of molecular species in a sample, each molecular specie being indicated by a dye. According to one embodiment, the amount of a plurality of molecular species is determined by acquiring a plurality of images of the sample, determining an amount of each molecular specie, as indicated by a respective dye, for each pixel at each corresponding pixel location in the plurality of images, and refining the amount of a plurality of molecular species at one or more pixel locations in the plurality of images. Associated systems and computer program products are also provided. | 10-18-2012 |
20120262565 | SENSOR DEVICE WITH IMAGING OPTICS - The invention relates to a method and a sensor device ( | 10-18-2012 |
20120268583 | Active Microscope Filter and Lighting System - The present invention discloses a unique and novel combination light source and active light filtering system for microscopes that eliminates the need for individual color filters, fluorescence filters, phase contrast filters, and many other filter types. The present invention provides almost unlimited light wavelength generation and filtering capabilities, as well as providing virtually unlimited dark field and phase contrast filter shapes, unique specimen lighting combinations, and all of the benefits of most commercially available light sources in a compact package that can be mounted on a microscope or used at a distance from a microscope, but be coupled to it through a fiber optic cable or other light transmission means. Additionally, the present invention eliminates the need for a filter wheel turret in a microscope's optical path, as well as eliminates the need for multiple fluorescent filter blocks in a fluorescent microscope optical path. The present invention can duplicate the functions of an almost infinite array of microscope filter systems to enable effective imaging of live cells without staining. | 10-25-2012 |
20120268584 | SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING - Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images. | 10-25-2012 |
20120274757 | CHARGED PARTICLE BEAM DEVICE AND A METHOD OF IMPROVING IMAGE QUALITY OF THE SAME - The invention relates to a technique of improving a contrast of a lower-layer pattern in a multi layer by synthesizing detected signals from a plurality of detectors by using an appropriate allocation ratio in accordance with pattern arrangement. In a charged particle beam device capable of improving image quality by using detected images obtained from a plurality of detectors and in a method of improving the image quality, a method of generating one or more output images from detected images corresponding to respective outputs of the detectors that are arranged at different locations is controlled by using information of a pattern direction, an edge strength, or others calculated from a design data or the detected image. In this manner, a detection area of the detected signals can be expanded by using the plurality of detectors, and the image quality such as the contrast can be improved by synthesizing the detected signals by using the pattern direction or the edge strength calculated from the design data or the detected images. | 11-01-2012 |
20120281081 | INFRARED IMAGING SYSTEM AND METHOD OF OPERATING - A lens unit ( | 11-08-2012 |
20120281082 | TUBE LENS, IMAGING OPTICAL SYSTEM AND MICROSCOPE - A tube lens used in combination with an objective of the infinity correction type that enlarges the image of an object includes a first lens group including a cemented lens and having a positive power, a second lens group having a negative power, and a third lens group including a positive lens and a negative lens and having a positive power as a whole, in this order from the object side. | 11-08-2012 |
20120287256 | SENSOR FOR MICROSCOPY - This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X | 11-15-2012 |
20120293644 | MICROSCOPE SYSTEM - A phase-contrast microscope system includes: an illumination optical system that illuminates a specimen with an illumination light from a light source; an imaging optical system that forms an image of the specimen from a light from the specimen; a first spatial modulation element that is disposed in a position of a pupil of the imaging optical system and changes an amplitude transmittance distribution of the light from the specimen; an image sensor that detects the image of the specimen by the imaging optical system and outputs a picture signal; a calculation section that calculates the amplitude transmittance distribution of the light from the specimen appropriate for observing the specimen on the basis of the output data detected by the image sensor and the amplitude transmittance distribution of the light from the specimen formed by the first spatial modulation element. | 11-22-2012 |
20120293645 | METHOD AND APPARATUS FOR ACQUIRING DIGITAL MICROSCOPE IMAGES - A method and apparatus for acquiring digital microscope images is disclosed, in which a plurality of magnified images of a specimen are captured for tiling together to provide an overall composite image of the specimen. In accordance with the described method, the specimen is moved relative to an imaging system comprising a microscope and camera in a predetermined path whilst the plurality of magnified images are captured. In a preferred embodiment, the specimen, contained on a slide, is mounted on a movable microscope stage, and is moved beneath the microscope in the predetermined path. The velocity of the movement of the stage and the shutter speed of the camera is computer controlled to capture overlapping, clear images. | 11-22-2012 |
20120300053 | IMAGE ACQUISITION DEVICE - Provided is a camera including a housing; an intermediate plate that divides the interior of the housing into first and second chambers; image acquisition elements disposed in the first chamber within the housing; a motor disposed in the second chamber within the housing; a pivot shaft that extends through the intermediate plate and transmits a driving force from the motor; a bearing that is provided in a through-hole area for the pivot shaft extending through the intermediate plate and seals a gap formed around the pivot shaft; and a prism that is connected to the pivot shaft in the first chamber and is moved by the driving force transmitted by the pivot shaft so as to switchably guide light from a sample to at least one of the image acquisition elements. | 11-29-2012 |
20120300054 | Method of Extracting Contour Lines of Image Data Obtained By Means of Charged Particle Beam Device, and Contour Line Extraction Device - The present invention is intended to provide a contour extraction method and a contour extraction device with an objective of either suppression of unnecessary contouring processings or selective contouring of necessary portions. To attain the objective, provided are a contour extraction method, and a device, with which contours of pattern edges on an image formed based on charged particles emitted from a sample are extracted and, when contouring of a pattern located in an overlapping region provided in connecting images of plural image-capturing regions to form a synthesized image is performed, either areas of the pattern in the plurality of image-capturing regions, or a pre-set measurement portion is found, and selective contour extraction of the pattern with respect to an image of an image-capturing region is carried out either on a side where the area is large, or on a side where a measurement portion regarding the pattern is located. | 11-29-2012 |
20120300055 | INTEGRATED CALIBRATION SAMPLE BAY FOR FLUORESCENCE READERS - A stage assembly, an imaging system that uses the stage assembly, and methods for using the stage assembly in a high content screening system. The stage assembly includes a stage having a top surface and an opposing bottom surface and an opening extending between the top and bottom surfaces to receive a specimen plate. The stage assembly also includes a calibration sample bay formed in the stage. A calibration sample can also be secured within the calibration sample bay. | 11-29-2012 |
20120307035 | SINGLE-SHOT FULL-FIELD REFLECTION PHASE MICROSCOPY - The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity. | 12-06-2012 |
20120307036 | ZOOM IMAGE-FORMING OPTICAL SYSTEM AND MICROSCOPE EQUIPPED THEREWITH - A zoom image-forming optical system used in combination with an infinity-correction objective lens, the zoom image-forming optical system including: a tube lens for condensing a luminous flux from the objective lens to form an intermediate image; and a relay lens with a zoom function for projecting the intermediate image onto an image plane. The relay lens includes a first lens group with positive power, a second lens group that belongs to a movable group with positive power, a third lens group that belongs to a movable group with positive or negative power, and a fourth lens group with negative power, in this order from the intermediate image side. The zoom image-forming optical system changes its magnifying power by moving the second lens group and the third lens group in an optical axis direction. | 12-06-2012 |
20120307037 | OBJECTIVE-COUPLED SELECTIVE PLANE ILLUMINATION MICROSCOPY - A microscope assembly includes an illumination source coupled to an optical assembly by a coupler. The optical assembly includes an objective with optics that move along an optic axis. The illumination source generates a light blade that illuminates a portion of a sample at an illumination plane. The light blade induces a fluorescent emission from the sample that is projected through the objective optics to a detector. The focal plane of the objective optics is fixed with respect to the illumination source by the coupler so that the illumination plane is coincident with the focal plane as the objective optics move along the optic axis. The objective and illumination may be rapidly scanned along the optic axis to provide rapid three-dimensional imaging while the objective and illumination may also be rapidly scanned along the optic axis to provide rapid three-dimensional imaging. | 12-06-2012 |
20120314049 | VIRTUAL TELEMICROSCOPE - The virtual telemicroscope system (VTS) of the present invention captures an entire image of a specimen on a test slide as an original high power image, signal processes the original high power image to generate a low power background image, generates an initial virtual slide based on the low power background image and posts and/or transmits the initial virtual slide to a remote user enabling the remote user to view the low power background image on a remote user's computer screen. While viewing the initial virtual slide, the remote user may identify (i.e., select) one or more specific areas on the background image and request the service provider to provide detailed images (e.g., higher magnified image than the background image) at the defined locations. In response, the VTS provides the remote user with the requested partial high power image by simply signal processing the original high power image and generating a secondary virtual slide based on the newly processed image. This process can be repeated until the remote user is satisfied with the viewing. | 12-13-2012 |
20120314050 | IMAGING APPARATUS AND CONTROL METHOD THEREFOR - An imaging apparatus comprises: a holding unit that holds a subject; a surface profile measuring unit that measures a surface profile of the subject; an imaging unit that adjusts an imaging plane according to the surface profile measured by the surface profile measuring unit and performs imaging of the subject; and a specifying unit that specifies a presence region in which an imaging object is present from an entire region of the subject. The surface profile measuring unit measures only the surface profile of the presence region specified by the specifying unit. | 12-13-2012 |
20120314051 | IMAGE PICKUP APPARATUS - An image pickup apparatus of the present invention includes a light source unit, an illumination optical system configured to introduce a light from the light source unit onto a plane to be illuminated, a sample stage configured to place an object on the plane to be illuminated, an image pickup optical system configured to form an image of the object placed on the plane to be illuminated, an image pickup element portion configured by disposing a plurality of image pickup elements on an image plane of the image pickup optical system, and a light shielding member configured to reduce entrance of a light to an area where the plurality of image pickup elements of the image pickup element portion are not disposed. | 12-13-2012 |
20120314052 | CATADIOPTRIC OPTICAL SYSTEM AND IMAGE-PICKUP APPARATUS HAVING THE SAME - A catadioptric optical system of the present invention includes a catadioptric unit configured to condense light fluxes from an object and to form an intermediate image of the object, a field lens disposed at a position where the intermediate image are formed, and a dioptric unit configured to form the intermediate image on an image surface, and when νcat denotes a smallest Abbe number in Abbe numbers of materials of the first and second optical elements configuring the catadioptric unit and νdio denotes a smallest Abbe number in Abbe numbers of materials of a plurality of dioptric optical elements configuring the dioptric unit, νdio<νcat is satisfied. | 12-13-2012 |
20120320182 | ELECTRO OPTICAL IMAGE-MAGNIFYING DEVICE - An electro optical image-magnifying device uses both a light image and electrons to form and enlarge the image. The device may be attached to a microscope or a telescope and may be placed in such a way that an image plane may fall on a photo cathode in the front of the device. The operator would view the image produced on a display screen, or thru an eyepiece, and would adjust a control power supply to achieve the desired magnification. The device may use both a light image and electrons to form and enlarge an image. The device may convert the light image into an electron wave representation. The electron wave representation may be manipulated electrically or magnetically, expanding its geometry and thus magnifying the image. | 12-20-2012 |
20120320183 | Method For Simulating An Aerial Image - An aerial image is generated by imaging an object with the use of an imaging optic, the object being illuminated by an illuminating optic by using a light source emitting illuminating radiation, the illuminating optic having a pupil plane. A first data set is defined to represent the object, a second data set is defined to represent the intensity distribution of the illuminating radiation in the pupil plane of the light source, and the aerial image is calculated from the first and the second data set, in which the resolution of the second data set varies according to the intensity or according to the location of the pupil plane. A microscope includes an imaging optic for imaging an object, a detector for capturing an aerial image of the object, and a processing unit for simulating aerial images generated by the microscope. | 12-20-2012 |
20120320184 | Microscope and Method for Fluorescence Imaging Microscopy - A microscope for fluorescence imaging microscopy, in particular for wide-field fluorescence microscopy, including a pulsed light source ( | 12-20-2012 |
20120320185 | DIFFRACTION MICROSCOPY - Disclosed is a diffraction microscopy capable of reducing influence of an increase in the incident angle range of a beam. Specifically disclosed is a diffraction microscopy in which a beam is incident on a sample, in which the intensity of a diffraction pattern from the sample is measured, and in which an image of an object is rebuilt using Fourier interactive phase retrieval on the basis of the measured intensity of the diffraction pattern. In this method, Fourier interactive phase retrieval is performed using deconvolution on the diffraction pattern subjected to convolution by the increase in the incident angle range of the beam. | 12-20-2012 |
20120320186 | CONTROLLING A SURGICAL MICROSCOPE - The invention relates to a method for controlling a surgical microscope ( | 12-20-2012 |
20120320187 | CATADIOPTRIC SYSTEM AND IMAGE PICKUP APPARATUS - The catadioptric system includes a first optical imaging system (catadioptric part) causing a light flux from an object to form an intermediate image and a second optical imaging system (dioptric part) causing the light flux from the intermediate image to form an image. In the first optical imaging system, the light flux sequentially passes a first transmissive portion, a second reflective portion, a first reflective portion and a second transmissive portion. In the second optical imaging system, consecutive four lens surfaces among plural lens surfaces placed between an aperture stop and an image surface have a negative combined refractive power, and a condition of −0.52<φ | 12-20-2012 |
20120327208 | IMAGING APPARATUS - An imaging apparatus comprises: an imaging unit having an imaging optical system and an imaging device; a measuring unit that measures, for each of a plurality of regions on a specimen, an optical aberration or a physical quantity causing the aberration before the imaging of the specimen is performed; a plurality of optical elements that are inserted in an optical path of the imaging optical system for correcting the aberration and that differ in correction amount; and a control unit that selects an optical element from among the optical elements on the basis of a measurement result of the measuring unit, and inserts the selected optical element into the optical path of the imaging optical system before the imaging of the specimen. The imaging optical system is configured to be capable of forming simultaneously images of the plurality of regions on the imaging device. | 12-27-2012 |
20120327209 | Method and Light Microscopy Apparatus for Producing an Image of a Sample - A sequence of individual images is acquired by imaging the sample through imaging optics onto an image sensor. For the acquisition of each individual image, the sample is provided with a marker pattern, in which individual markers can be imaged in the form of spatially separable light distributions through the imaging onto the image sensor. The centroid positions of the light distributions are determined and superimposed to form a complete image of the sample. According to the present invention, an image-drift-inducing temperature value (ΔT | 12-27-2012 |
20120327210 | OBSERVING APPARATUS AND OBSERVATION METHOD - A certain material irregularly expressed in an observation area is effectively observed. An observing apparatus includes a first observing unit performing a time lapse shooting of a predetermined observation area, a first discriminating unit discriminating whether or not a first material is expressed in the observation area based on an image obtained by the first observing unit, and a second observing unit starting a time lapse shooting relating to a part where the first material is expressed at a timing when the first material is expressed in the observation area, in which a shooting frequency of the time lapse shooting by the second observing unit is higher than a shooting frequency of the time lapse shooting by the first observing unit. | 12-27-2012 |
20120327211 | DIAGNOSTIC INFORMATION DISTRIBUTION DEVICE AND PATHOLOGY DIAGNOSIS SYSTEM - A diagnostic information distribution device is configured to be communicable with multiple pathology diagnosis devices and to distribute diagnostic information to the pathology diagnosis devices, and includes: an image acquiring unit that acquires a specimen image by imaging a diagnosis target specimen; a diagnostic area extracting unit that extracts a diagnostic area from the specimen image; a providing information creating unit that modifies the image data of at least the diagnostic area into an image of an image type corresponding to an observation procedure correlated with a request pathologist who is requested to make a diagnosis so as to create providing information; and a providing information distributing unit that distributes diagnostic information including the providing information to the pathology diagnosis device of the request pathologist. | 12-27-2012 |
20130002847 | SYSTEMS AND METHODS FOR SAMPLE DISPLAY AND REVIEW - Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells. | 01-03-2013 |
20130010098 | High-Resolution Microscope and Method for Determining the Two- or Three-Dimensional Positions of Objects - The invention relates to a high-resolution microscope and to a method for determining the two- or three-dimensional positions of objects. The microscope and method includes the following: (a) The vertical (Z) position of imaged particles or molecules being determined from the orientation and shape thereof by means of an anamorphic lens, preferably a cylindrical lens, in the imaging, (b) the detection beam path being split into at least two partial detection beam paths having different optical path lengths, which are detected at an offset on a detector, (c) activation or switchover being performed by means of a multi-photon excitation process, preferably two-photon excitation. The following are also included: (d) a point-scanning activation or switchover, (e) a line-scanning activation or switchover, (f) the sample is excited and the sample light is detected in the wide-field mode, (g) manually or automatically predetermined sample regions are activated or switched over, (h) the activation or switchover is performed by means of AOTF or SLM or DMD, (i) laser pulses for activating or switching are spectrally split by means of a spectrally splitting element, preferably a grating, (j) an SLM or DMD in the beam path after the grating performs a controlled selection of split laser pulse fractions, (k) the laser wide-field excitation is guided by SLM or DMD, (l) ROIs are selected by SLM or DMD, (m) a multi-photon switching or activation is performed by means of a microlens array, preferably a cylindrical lens array, n) switching and/or excitation is performed by means of a line scanner, and (o) a line detection is performed by means of a spatially resolved sensor, wherein at least two sensor rows, each comprising a plurality of sensors, are illuminated with sample light by means of a slit diaphragm position. | 01-10-2013 |
20130010099 | SYSTEM FOR TESTING SEMICONDUCTORS - A system that includes an imaging device for effectively positioning a probe for testing a semiconductor. | 01-10-2013 |
20130016204 | Microscope DeviceAANM Hocke; MarcAACI HeerbruggAACO CHAAGP Hocke; Marc Heerbrugg CHAANM El Haddouchi; HakimAACI BalgachAACO CHAAGP El Haddouchi; Hakim Balgach CH - A microscope device ( | 01-17-2013 |
20130027538 | MULTI-REGION FOCUS NAVIGATION INTERFACE - A multi-region focus navigation interface for a machine vision inspection system is provided to assist a user with user-directed or manual focus operations. The multi-region focus navigation interface comprises a plurality of regional focus elements, each corresponding to a respective region of interest and superimposed on a displayed field of view. Each focus element comprises at least first and second operating states corresponding to its focus distance being in a close or intermediate range, respectively. Each operating state comprises a respective graphical focus indicator. For the intermediate range, a focus improvement direction may also be indicated. In one embodiment, in the close range operating state, a user may activate a region focus element to perform autofocus operations, while in the intermediate range operating state, a user may activate a focus element to perform operations that move toward the focus height by a predetermined step size. | 01-31-2013 |
20130027539 | CELL OBSERVING APPARATUS AND CELL INTEGRATION METHOD - User's time and labor required for performing manipulations with respect to cells which exist in an incubation container, are reduced. To achieve the above, a cell observing apparatus includes an observation stage supporting an incubation container that houses cells, a micro imaging optical system forming, on an imaging device for micro imaging, an image of the cell in the incubation container disposed at an observing position of the observation stage, a macro imaging optical system forming, on an imaging device for macro imaging, an image of an area wider than that captured by the micro imaging optical system in the incubation container, and a controlling unit controlling an operation of a manipulation needle that manipulates the cells in the incubation container, in which the micro imaging optical system is disposed on a side facing the macro imaging optical system with the observation stage being located therebetween. | 01-31-2013 |
20130027540 | PARTICLE MEASURING DEVICE AND PARTICLE MEASURING METHOD - This particle measuring device includes a stage, a reflected light illuminating device, a transmitted light illuminating device, an illumination control device, an imaging device, and an image processing device. Based on a transmitted light image acquired by imaging an opaque fine particle group using transmitted light and a reflected light image acquired by imaging an opaque fine particle group using reflected light, by associating transmitted light particles present in the transmitted light image and reflected light particles present in the reflected light image with each other using a predetermined method, various characteristics (the position, the size, the brightness level, and the like) of individual particles out of a fine particle group are simultaneously measured. | 01-31-2013 |
20130038713 | REFLECTED DARK FIELD METHOD AND APPARATUS - A reflected dark field structure includes a bottom plate, a support tube, a light unit, a diffuser structure, and a reflector unit that provides reflected dark field illumination, such that a gem held by the support tube and surrounded by the diffuser structure is illuminated and viewable through an aperture in the reflector unit. A method for imaging and analyzing a gem includes placing the gem onto a support tube where it is illuminated with dark field and reflected dark field illumination, and viewing the gem via an aperture located on a top reflector unit, which provides a top cover for the gem. Furthermore, a method and apparatus for obtaining images of a gem includes a dark field stage, a reflector unit, and an image-acquiring device, such that a gem placed in the dark field stage is illuminated, and such that the reflector unit covers the dark field stage and provides reflected dark field illumination, and such that the image-acquiring device is directed towards an aperture in the reflector unit. | 02-14-2013 |
20130044200 | SYSTEM AND APPARATUS FOR THE CALIBRATION AND MANAGEMENT OF COLOR IN MICROSCOPE SLIDES - A system and apparatus for the color calibration of images recorded through a microscope. An integrated color calibration target microscope slide device and specimen are recorded with an imaging device that acquires both the color values of the specimen and the color values of the color calibration target under a plurality of illuminations and trans-illuminations. A composite image is formed to provide a spectral estimation of the relevant color values of the image. The image is converted into multi-stimulus values governed by a plurality of illuminating conditions. The multi-stimulus values are used to provide image calibration data so that color values of the image, when displayed on a display devices, are faithfully reproduced. | 02-21-2013 |
20130044201 | HAND-HELD FLUORESCENCE MICROSCOPE WITH PARTIAL-SPECTRUM LIGHT SOURCE - A hand-held fluorescence microscope is disclosed, including: a partial-spectrum light source, a first filtering device, a second filtering device, and an image sensor arranged inside a housing of the hand-held fluorescence microscope. The partial-spectrum light source generates a first light beam. The first filtering device filters the first light beam to provide a second light beam. The second filtering device filters a fluorescence generated by a specimen after receiving the second light beam to provide a fourth light beam. The image sensor receives the fourth light beam to generate fluorescence images. One end of the housing is provided with a light mask for surrounding the specimen to avoid external light from being entering the image sensor. The light path of the second light beam projecting to the specimen does not overlap with the light path of the fluorescence radiating from the specimen to the second filtering device. | 02-21-2013 |
20130044202 | DIGITAL MICROSCOPE - A digital microscope ( | 02-21-2013 |
20130050463 | IMAGE ACQUISITION DEVICE - Size reduction is achieved while also achieving both high sensitivity and high pixel density. Provided is an image acquisition device including an image acquisition element that acquires an image of a sample, a closed container that accommodates and seals the image acquisition element therein, a camera body that accommodates the closed container, and a displacement member that moves the image acquisition element relative to the camera body in a direction perpendicular to an optical axis of the image acquisition element. At least a portion of the displacement member is disposed outside the closed container. | 02-28-2013 |
20130050464 | Magnification Observation Device, Magnification Observation Method, And Magnification Observation Program - Provided are a magnification observation device, a magnification observation method, and a magnification observation program in which connected image data can be efficiently obtained in a short period of time when re-imaging an object to obtain the connected image data corresponding to a plurality of unit regions. A plurality of unit regions on a surface of an observation object are imaged, and a plurality of pieces of image data respectively corresponding to the plurality of unit regions are generated. An image of the object including the plurality of unit regions is displayed as a region presentation image. When any of the plurality of unit regions is selected by a selection instruction from a user, the selected unit region is re-imaged, to generate image data corresponding to the selected unit region as re-imaged data. | 02-28-2013 |
20130057672 | IMAGING APPARATUS AND CONTROL METHOD - There is provided an imaging apparatus that includes a reception section, and an output section. The reception section is configured to receive a trigger from an external apparatus at a timing for reset and readout of an imaging element. The output section is configured to provide back, to the apparatus, a status indicating in which state the imaging element is when the reception section receives the trigger. | 03-07-2013 |
20130057673 | INSTRUMENT FOR THE REALISATION OF WIDE-FIELD IMAGES AT DIVERSE DEPTHS OF A SPECIMEN - Instrument for obtaining wide field images of a specimen comprising (1) a divergence disperser, generating within a light beam different divergences in each of the chromatic components thereof to form images of the specimen at different depths thereof, and (2) a wavelength analyser, selecting the wavelength or interval of wavelengths of the light beam to form the image of the specimen at a specific depth. The light beam may be mono- or polychromatic and the instrument may have a configuration of illumination by transmission or by reflection. The instrument may moreover be modified through diverse configurations of the divergence disperser and/or of the wavelength analyser, including the motorisation thereof or the inclusion of a movable mask, together with being coupled to a CCD or CMOS camera to integrate the diverse images acquired from all sections of the specimen. | 03-07-2013 |
20130057674 | AUTOFOCUS IMAGING - The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis. | 03-07-2013 |
20130063583 | SYSTEM AND METHOD FOR DIGITIZING A MOVING SLIDE - The present invention relates to a system and a method of digitizing a moving slide ( | 03-14-2013 |
20130063584 | TIME LAPSE OBSERVATION METHOD, AND TIME LAPSE OBSERVATION APPARATUS AND MULTIPHOTON MICROSCOPE USED THEREFOR - Time lapse observation method includes: before a process to obtain a first time lapse image, capturing an image of a reference area on a sample being a partial area of a target area or an area in a vicinity of the target area being a smaller area than the target area to obtain a reference image; storing a position of a capturing area in capturing the reference image as a reference position; before a process to obtain the time lapse image performed, setting a position of the capturing area sequentially at different positions in the optical axis direction of an objective including the reference position and capturing an image at each of the positions to obtain comparison target images; and matching the capturing area with the target area, based on a comparison result of the reference image and the comparison target images. | 03-14-2013 |
20130063585 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus includes a storage unit, a determination unit, and a generation unit. The storage unit stores a plurality of partial images obtained by taking images with respect to a subject so that a plurality of image taking areas are overlapped with each other and relative positional displacement information of two adjacent partial images out of the plurality of partial images, the positional displacement information being calculated for each of the two adjacent partial images. The determination unit determines at least one display partial image for generating a display area image from the plurality of partial images, the display area image being an image of an area displayed as an image of the subject. The generation unit connects, when a plurality of display partial images are determined, the plurality of display partial images on the basis of the positional displacement information, to generate the display area image. | 03-14-2013 |
20130063586 | OPTICAL MODULATOR DEVICE AND SPATIO-TEMPORALLY LIGHT MODULATED IMAGING SYSTEM - An optical modulator device ( | 03-14-2013 |
20130070075 | MAGNIFYING OBSERVATION APPARATUS, AND IMAGE DISPLAY METHOD AND MICROSCOPY SWITCHING METHOD THEREOF - A magnifying observation apparatus includes a switching unit for switching between a plurality of microscopies, an image generating unit for generating an image of a sample by capturing an image of the sample with the respective plurality of microscopies switched by the switching unit, and a display unit for displaying the image generated by the image generating unit. The display unit updates a display of the display unit each time a new image is generated by the image generating unit. | 03-21-2013 |
20130070076 | AUTOFOCUSING METHOD AND DEVICE FOR A MICROSCOPE - A method and device for autofocusing in a microscope ( | 03-21-2013 |
20130070077 | Systems and Methods for Analyzing Body Fluids - Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device. | 03-21-2013 |
20130076886 | Automatic Focus and Sample Detection - Imaging systems, such as optical microscopes, can benefit from automatic focus enhancements including sample detection. For example, systems that use a charge coupled device (CCD) video camera to capture a field of view for making focus determinations can benefit from automatic focus and sample detection. A method according to certain embodiments can include obtaining, by a machine, a high level image of a sample. The method can also include determining, by the machine, whether a plurality of auto-focus areas of a plurality of fields of view are aligned with a portion of the sample. The method can further include obtaining, by the machine, a low level image of the sample when the plurality of auto-focus areas are aligned. | 03-28-2013 |
20130076887 | MICROSCOPE SYSTEM AND MICROSCOPE FRAME - A microscope system includes a microscope frame on which a stage is placed; and a camera head, in which an objective lens is attachable, for capturing an image of a specimen, the camera head being attached to the microscope frame by being fitted, and being slidable with respect to the microscope frame in a direction that is parallel with a surface of the stage placed on the microscope frame and orthogonal to an optical axis of the attached objective lens. | 03-28-2013 |
20130076888 | MICROSCOPE SYSTEM - A microscope includes a zoom optical system zooming over a sample, a zoom driving unit moving the optical system along an optical axis, an imaging unit imaging an observation image of the sample through the optical system, thereby generating image data on the sample, and a display unit displaying an image corresponding to the generated image data. A touch panel on a display screen of the display unit accepts an input corresponding to a contact position of an object. A driving control unit outputs a driving signal for changing a zoom magnification of the optical system by setting a middle point between contact positions on the touch panel corresponding to two position signals responsive to an input of the different contact positions as a zoom center position fixed without depending on the zoom magnification of the optical system when the two position signals are output from the touch panel. | 03-28-2013 |
20130083186 | SUPER-RESOLUTION OBSERVATION APARATUS - Super-resolution observation apparatus includes excitation light irradiation unit for irradiating excitation light intended to excite a sample on the sample, excitation light modulation unit for modulating a spatial intensity distribution of the excitation light on the sample, enlarged image forming unit for forming an enlarged image of the sample at an image position from observation light generated by irradiating the excitation light on the sample, image capturing unit for converting a spatial intensity distribution of the enlarged image into digital image data, and super-resolution processing unit for generating a super-resolution image where a super-resolution frequency component higher than a cutoff frequency of the enlarged image forming unit is made visible from one or a plurality of pieces of the digital image data. The super-resolution processing unit includes spatial frequency intensity modulation unit that change process contents according to an intensity level of a noise included in the digital image data. | 04-04-2013 |
20130088585 | SURFACE IMAGING WITH MATERIALS IDENTIFIED BY COLOR - An imaging system receives a height measurement and a resistance measurement, the measurements being made at a two-dimensional position on a surface. A display system maps the resistance to a predetermined material color value, and displays the height measurement and the material color value at the two-dimensional position on the surface. | 04-11-2013 |
20130088586 | Magnification Observation Device - Provided is a magnification observation device capable of easily moving an observation object in a desired direction even when a stage is rotated, and capable of preventing a desired region of the observation object from going outside an imaging region due to rotation of the stage. The observation object is placed on the placement surface of the stage. The observation object is imaged by an imaging unit, to acquire image data of the imaging region. Based on the image data acquired by the imaging unit, an image of the observation object is displayed by the display part as an observed image. The stage is moved relatively with respect to the imaging unit along an x | 04-11-2013 |
20130093871 | OMNIDIRECTIONAL SUPER-RESOLUTION MICROSCOPY - A microscopy method and apparatus includes placing a specimen to be observed adjacent to a reflective holographic optical element (RDOE). A beam of light that is at least partially coherent is focused on a region of the specimen. The beam forward propagates through the specimen and is at least partially reflected backward through the specimen. The backward reflected light interferes with the forward propagating light to provide a three dimensional interference pattern that is at least partially within the specimen. A specimen region illuminated by the interference pattern is imaged at an image detector. Computational reconstruction is used to generate a microscopic image in all three spatial dimensions (X,Y,Z), simultaneously with resolution greater than conventional microscopy. | 04-18-2013 |
20130093872 | Magnification Observation Device - Provided is a magnification observation device in which a focus of the imaging unit can be focused on the observation surface of the object in observation object region in a short period of time. An unit region of an observation object is imaged at a plurality of Z-positions by moving a object lens in the light-axis direction, the plurality of pieces of image data corresponding to the unit region are captured. An image of the observation object is displayed in the display unit as a navigation image. Shape data which indicates the position of the surface of the observation object in the unit region is generated. An observation object region on observation object is designated based on the navigation image. Based on the generated shape data, a focus of the object lens is on the surface of the observation object on the observation object region designated. | 04-18-2013 |
20130093873 | SYSTEM FOR SYNCHRONIZATION IN A LINE SCANNING IMAGING MICROSCOPE - A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit. | 04-18-2013 |
20130093874 | AUTOFOCUS BASED ON DIFFERENTIAL MEASUREMENTS - The present invention relates to the field of digital pathology and in particular to whole slide scanners. A tilted autofocus image sensor images an oblique cross-section of the slide. For focusing multiple sequential overlapping images, which have been taken by the tilted sensor, are compared. The axial position of the tissue layer can be determined from the polar error signal resulting from this differential measurement. | 04-18-2013 |
20130100272 | Multifunction autofocus system and method for automated microscopy - Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction. | 04-25-2013 |
20130100273 | MICROSCOPE APPARATUS - A microscope apparatus includes a λ stack image data acquisition unit that detects light emitted composed of a sample for each wavelength to acquire λ stack image data from multiple image data items for multiple different wavelengths; a spectrum generation unit that generates a spectrum for each pixel based on the λ stack image data; a clustering unit that performs clustering of the spectrum for each pixel into multiple clusters; a color setting unit that sets different colors to the clusters; and an image generation unit that generates an image of the sample by displaying pixels included in the clusters with a color set by the color setting unit. The distribution and gray scale of fluorescent materials within the sample can be correctly recognized and the state of a desired tissue can be favorably observed. | 04-25-2013 |
20130107030 | OPTICAL MEASUREMENT SYSTEM AND METHOD FOR MEASURING CRITICAL DIMENSION OF NANOSTRUCTURE | 05-02-2013 |
20130113911 | ILLUMINATION DEVICE AND OBSERVATION SYSTEM - An illumination device and an observation system capable of outputting light having a continuous spectrum and high color rendering properties are provided. Employed is an illumination device including a first light source that emits first-wavelength-band light having a first wavelength band of violet color; a second light source that emits second-wavelength-band light having a second wavelength band that is broader than the first wavelength band and having a continuous spectrum; a light combining section that is composed of a dicroic mirror and that combines the first-wavelength-band light and the second-wavelength-band light; and a combination-ratio adjusting section that adjusts the combination ratio of the first-wavelength-band light and the second-wavelength-band light to be combined by the light combining section. | 05-09-2013 |
20130120550 | EXTENDED DEPTH OF FIELD MICROSCOPE SYSTEM - An extended depth of field microscope system for phase object detection includes an imaging optical module and a phase/intensity converting module. The imaging optical module has an object lens group, in which an axial symmetric phase coding is added, to produce an axial symmetric spherical aberration. A point spread function (PSF) and an image with extended depth of field can be obtained with a predetermined level of similarity. The phase/intensity converting module converts the phase change of the light passing the phase object, into an image light with change of light intensity. | 05-16-2013 |
20130128024 | IMAGE OBTAINING APPARATUS, IMAGE OBTAINING METHOD, AND IMAGE OBTAINING PROGRAM - An image obtaining apparatus includes: a light source configured to irradiate a biological sample having a fluorescent label with an excitation light, the excitation light exciting the fluorescent label; a focus moving unit configured to move a focus position of an optical system in the thickness direction of the biological sample; and a data processing unit configured to expose an image sensor to light while moving the focus position of the optical system in each of a plurality of preset scanning ranges to thereby obtain fluorescent images of the biological sample, each of the plurality of scanning ranges having a predetermined scanning length, the predetermined scanning length being smaller than the length of a bright-point detection range of the biological sample in the thickness direction, the center positions of the scanning ranges being different from each other in the thickness direction. | 05-23-2013 |
20130128025 | Device and Method for Acquiring a Microscopic Image of a Sample Structure - A device and a method for acquiring a microscopic image of a sample structure are described. An optic for imaging the sample structure and a reference structure is provided, as well as a drift sensing unit for sensing a drift of the sample structure relative to the optic on the basis of the imaged reference structure. The optic comprises a first sharpness plane for imaging the sample structure and at the same time a second sharpness plane, modifiable in location relative to the first sharpness plane, for imaging the reference structure. | 05-23-2013 |
20130135456 | IMAGE OBTAINING APPARATUS, IMAGE OBTAINING METHOD, AND IMAGE OBTAINING PROGRAM - An image obtaining apparatus includes: a light source configured to irradiate a biological sample having a fluorescent label with excitation light, the excitation light exciting the fluorescent label; an optical system including an objective lens, the objective lens being configured to magnify an imaging target of the biological sample; an image sensor configured to form an image of the imaging target magnified by the objective lens; a movement controller configured to move a focus position of the optical system in an imaging range including at least a range corresponding to the thickness of the imaging target; and a data processing unit configured to exposure the image sensor to light while moving the focus position in the imaging range and obtain a fluorescent image of the biological sample, to thereby calculate distribution information of the fluorescent label in a thickness direction of the imaging target based on the fluorescent image. | 05-30-2013 |
20130141561 | METHOD OF ANALYZING LINEARITY OF SHOT IMAGE, IMAGE OBTAINING METHOD, AND IMAGE OBTAINING APPARATUS - Provided is a method of analyzing a linearity of a shot image, including: irradiating a biological sample having a fluorescent label with an excitation light, the excitation light exciting the fluorescent label, and exposing an image sensor to light while moving a focus position of an optical system including an objective lens in an optical-axis direction and in a direction orthogonal to the optical-axis direction; and analyzing a gamma value for an imaging environment based on a brightness distribution of one bright-point image in a real-shot-image obtained by the image sensor. | 06-06-2013 |
20130141562 | MICROSCOPE - A microscope according to the present invention includes an imaging unit including a first illuminating unit, an imaging element, and a projection optical system, the first illuminating unit including a light source that illuminates a first object, the imaging element performing imaging of the first object, the projection optical system projecting an image of the first object onto the imaging element; a measuring unit configured to measure a second object for setting an imaging condition used when performing imaging of the second object at the imaging unit; and a controller configured to concurrently perform the imaging of the first object at the imaging unit and the measurement of the second object at the measuring unit. | 06-06-2013 |
20130141563 | IMAGE FORMING DEVICE AND COMPUTER PROGRAM - The purpose of the present invention is to provide an image forming apparatus and a computer program such that extraction of information about distortion in a charged particle beam scan area can be implemented. An embodiment for achieving the purpose proposes: an image forming apparatus that integrates image data obtained by a charged particle beam apparatus and that calculates, from a plurality of images with different scan directions of the charged particle beam apparatus, first information about the amount of change in a feature quantity in accordance with the time of irradiation of the charged particle beam, second information about the amount of change in the feature quantity before and after a change in beam scan direction, and/or third information about a position error of a pattern on the image before and after the change in beam scan direction; and a computer program for causing a computing apparatus to perform the above process. | 06-06-2013 |
20130147939 | IMAGE ACQUISITION APPARATUS AND METHOD FOR ADJUSTING IMAGE ACQUISITION APPARATUS - An image acquisition apparatus includes a test object stage that holds a test object, a measuring unit that acquires surface profile information of the test object, and a microscope unit that includes an objective optical system that forms an image of the test object and an image pickup element that captures the image of the test object formed by the objective optical system. The test object stage is movable between a measurement position of the measuring unit and a imaging position of the microscope unit. The measuring unit acquires first stage inclination information of the test object stage. At the imaging position, the test object stage adjusts an orientation thereof on the basis of a relationship between the surface profile information and the first stage inclination information. | 06-13-2013 |
20130147940 | CELL COUNTER AND METHOD OF MANUFACTURING THE SAME - A cell counter includes: a sample slide configured to accommodate cells; a housing configured to be inserted into the inside of the sample slide from the outside of the sample slide; an object lens configured to be mounted within the housing, and to image-form a cell image for the cells projected from the sample slide; an image acquisition unit configured to be mounted within the housing together with the object lens, and to acquire the cell image image-formed by the object lens; and a first reflecting mirror provided between the sample slide and the object lens within the housing, and configured to change a projection direction of the cell image projected from the sample slide to the object lens. | 06-13-2013 |
20130155218 | High Resolution Microscope and Image Divider Assembly - The invention relates to a microscope having an illumination beam path with wide field illumination of a sample and a first detection beam path having a spatially resolved surface receiver, which is reached by a first part of the detection light coming from the sample via the first detection beam path, or an image divider assembly for a microscope. In order to lengthen the optical path length, at least a second part of the detection light coming from the sample is masked out of the detection beam path and, via deflection means belonging to the detection beam path, is led into a second detection beam path and, preferably via further deflection means, is deflected back in the direction of the detection in such a way that detection light is applied to at least two partial regions beside one another on the surface receiver. At least the second part of the detection light runs in an optical element having an optical density that is increased as compared with the first detection beam path, in order to lengthen the optical path length, and the optical element is designed to be displaceable at an angle, preferably perpendicular, to the optical axis of the first detection beam path in order to adjust the optical path length, and has flat surfaces, at least on the light entry and light exit side thereof; a prism is provided, preferably a glass prism, preferably at least in the second detection beam path after a first beam deflection, for deflection in a direction parallel to the first detection beam path, in order to increase the path length and for reverse deflection. | 06-20-2013 |
20130155219 | IMAGE PROCESSING APPARATUS - Optimal shading correction is achieved even when exposure times are different. An apparatus includes a section that stores a γ property of an image pickup device, a section that stores a shading pattern acquired by the image pickup device, and a first exposure time, a section that stores image data acquired by the image pickup device and a second exposure time, a section that calculates a pre-correction pattern, based on the stored shading pattern and the stored γ property, a section that calculates a revised pattern by performing γ correction for the calculated pre-correction pattern after multiplying the calculated pre-correction pattern by a ratio of the second exposure time to the first exposure time, and a section that performs shading correction for the stored image data by using the calculated revised pattern. | 06-20-2013 |
20130162800 | QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT - Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei. | 06-27-2013 |
20130162801 | MICROSCOPE - Provided is a microscope which includes an image pickup element, a light source, an optical system, a control unit and a sensor. The control unit controls for the acquisition of, in parallel with the first image pickup event by the image pickup element, necessary information when the second image pickup event by the image pickup element is performed, by using the sensor. A pair of sensors for a microscope includes a pair of sensors. A first sensor of the pair of sensors provides a signal that represents an environmental variable of a first area at a first period in time. A second sensor of the pair of sensors provides a signal that represents a quality of the first sensor's ability to represent the environmental variable of a second area at the first period in time, wherein the second sensor is adjacent to the first sensor. | 06-27-2013 |
20130162802 | Fully Automatic Rapid Microscope Slide Scanner - Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging. | 06-27-2013 |
20130162803 | MOSAIC PICTURE GENERATION - A stability and, thus, also a quality of mosaic generation is improved by exploiting the advantages of global optimization while giving up performing the optimization fully on the basis of mutual alignment of the image information alone, i.e. on the basis of the result of a search for similarities, but when, additionally, information about error statistics of the capturing device, which took over portion-by-portion capturing of the object plane, is instead also taken into account in the positioning of the subimages in that a secondary constraint (secondary constraint) is set up for the capturing position variables in the optimization problem. | 06-27-2013 |
20130162804 | Method and Apparatus For Automatic Focusing of Substrates in Flourescence Microscopy - An apparatus for automated examination of biological material ( | 06-27-2013 |
20130169787 | IMAGE PROCESSING DEVICE, IMAGING DEVICE, MICROSCOPE DEVICE, IMAGE PROCESSING METHOD, AND IMAGE PROCESSING PROGRAM - The image processing device | 07-04-2013 |
20130169788 | MICROSCOPE, IMAGE ACQUISITION APPARATUS, AND IMAGE ACQUISITION SYSTEM - A microscope | 07-04-2013 |
20130182096 | OPTICAL TISSUE SECTIONING USING FULL FIELD OPTICAL COHERENCE TOMOGRAPHY - According to a first aspect, the invention relates to a multimodal optical sectioning microscope ( | 07-18-2013 |
20130188033 | RECORDING MEDIUM HAVING OBSERVATION PROGRAM RECORDED THEREIN AND OBSERVATION APPARATUS - A recording medium having an observation program recorded therein, the program may cause a computer to execute: an entire-image-pickup process of picking up an image of a sample by picking up an image of an entire container containing the sample and a solution; a sample-mass-identification process of identifying a sample mass having the samples gathering therein, from the image picked up in the entire image-pickup process; a sample-mass-determination process of extracting shape information of the identified sample mass, and determining a state of the sample mass based on the shape information; a coordinate-detection process of selecting a magnifying-observation-target sample mass from the identified sample masses, and detecting coordinates of the center of the magnifying-observation-target sample mass. | 07-25-2013 |
20130188034 | IR microscope with image field curvature compensation, in particular with additional illumination optimization - An IR microscope ( | 07-25-2013 |
20130188035 | CALIBRATION TARGETS FOR MICROSCOPE IMAGING - This disclosure is directed to optical microscope calibration devices that can be used with optical microscopes to adjust the microscope imaging parameters so that images of samples can be obtained below the diffraction limit. The microscope calibration devices include at least one calibration target. Each calibration target includes a number of features with dimensions below the diffraction limit of a microscope objective. Separate color component diffraction limited images of one of the calibration targets are obtained for a particular magnification. The color component images can be combined and image processed to obtain a focused and non-distorted image of the calibration target. The parameters used to obtain the focused and non-distorted image of the calibration target can be used to obtain focused and non-distorted images of a sample for the same magnification by using the same parameters. | 07-25-2013 |
20130194409 | MULTI-PHOTON FLUOROSCOPY ATTACHMENT MODULE FOR A SURGICAL MICROSCOPE - The present invention relates to an attachment module ( | 08-01-2013 |
20130194410 | CELL OCCUPANCY MEASUREMENT - A method for determining cell occupancy, confluency and cell migration in a cell culture, comprising receiving data related to pixel intensity in an image acquired of the cell culture, and distinguishing between cell concentrations in different locations in the cell culture by detecting variations in pixel intensity between multi pixel locations. | 08-01-2013 |
20130201321 | METHOD AND APPARATUS FOR TESTING LIGHT-EMITTING DEVICE - Disclosed is a method for testing a light-emitting device comprising the steps of: providing an integrating sphere comprising an inlet port and a first exit port; disposing the light-emitting device close to the inlet port of the integrating sphere; providing a current source to drive the light-emitting device to form an image of the light-emitting device in driven state; providing an image receiving device and to receive the image of the light-emitting device, wherein the image receiving device is connected to the first exit port of the integrating sphere; and determining a luminous intensity of the light-emitting device according to the image. An apparatus for testing a light-emitting device is also disclosed. The apparatus for testing a light-emitting device comprises: an integrating sphere comprising an inlet port and a first exit port, wherein the light-emitting device is disposed close to the inlet port of the integrating sphere; an image receiving device connected to the first exit port of the integrating sphere for receiving an image of the light-emitting device; and a processing unit coupled to image receiving device for determining a luminous intensity of the light-emitting device. | 08-08-2013 |
20130215251 | IMAGING APPARATUS, IMAGING CONTROL PROGRAM, AND IMAGING METHOD - An imaging apparatus includes: a first imaging area setting unit configured to divide an imaging range that includes a sample into a plurality of areas and set each of the plurality of areas as a first imaging area; a first imaging unit configured to capture a first image at an in-focus position of the first imaging area; a second imaging area setting unit configured to set an area that extends over adjacent first imaging areas as a second imaging area in a case where in-focus positions of the adjacent first imaging areas are so different from each other that the difference exceeds a predetermined value; a second imaging unit configured to capture a second image at an in-focus position of the second imaging area; and an image combining unit configured to combine the first image with the second image. | 08-22-2013 |
20130215252 | SAMPLE IMAGING SYSTEM AND METHOD FOR TRANSMITTING AN IMAGE OF CELLS OR TISSUES LOCATED IN A CULTURING SPACE TO DATA PRCESSING MEANS - A microscope unit positioned in a culturing space for imaging cells or tissues also located therein. The microscope unit has a frame, an object holder provided on the frame and allowing the cells or tissues to be held substantially immobile during a culturing period, an imaging device arranged on the frame for the optical imaging of the cells or tissues held on the object holder and an image capturing device for capturing an image projected by the imaging device. A connection leading out of the culturing space provides electrical power to the microscope unit and is adapted to be connected to a control unit and, in turn, a processor, both located outside of the culturing space. The invention also relates to a method for monitoring cells or tissues located in the culturing space and transmitting the image thereof. | 08-22-2013 |
20130222567 | MICROSCOPE AND METHOD FOR WAVELENGTH-SELECTIVE AND HIGH SPATIAL RESOLVING MICROSCOPY - A method for wavelength-selective and high spatial resolving fluorescence microscopy. In a specimen fluorescence emitters are repeatedly excited and specimen frames are produced with a microscope. The fluorescence emitters are excited to emit fluorescence radiation such that at least a sub-set is isolated in each frame and the positions of the isolated fluorescence emitters are localized with a localization precision exceeding the optical resolution and a high-resolution complete image is produced. The imaging beam path of the microscope has a spectrally selective element which, during production of the frames, generates a spectrally-dependent rotational asymmetric point-spread function, such that images of isolated fluorescence emitters have a rotational asymmetry which depends on a wavelength at which the isolated fluorescence emitters fluoresce, and the images of the isolated fluorescence emitters are analysed with respect to rotational asymmetry and an indication of the wavelength of the isolated fluorescence emitters is derived therefrom. | 08-29-2013 |
20130222568 | Method and Device for Light-Microscopic Imaging of a Sample Structure - A method for light-microscopy imaging of a sample structure ( | 08-29-2013 |
20130222569 | IMAGING APPARATUS - An imaging apparatus includes: an illumination optical system including a light source and guiding the light from the light source to an illuminated surface B including an object; a plurality of image sensors for acquiring an image of the illuminated surface formed by an imaging optical system; a measurement unit for measuring a size of the object; and a control unit for determining an image sensor to be used when acquiring the image of the illuminated surface, among the plurality of image sensors, based on a measurement result of the measurement unit. | 08-29-2013 |
20130235180 | SUPER-OSCILLATORY LENS APPARATUS AND METHODS - An imaging apparatus is disclosed which uses a super-oscillatory lens to obtain sub-diffraction limit resolution. The super-oscillatory lens is arranged to receive a light beam from a light source, the lens having a pre-defined pattern to spatially modulate the light beam in amplitude and/or phase so that it focuses the light beam to a focus at a first focal point having a full width half maximum of less than half the wavelength. Collection optical elements are arranged to focus the first focal point to a second focal point conjugate to the first focal point. An object for imaging is scanned over the first focal point and a detector is arranged to collect light from a collection region centered on the second focal point. | 09-12-2013 |
20130235181 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, AND IMAGING APPARATUS INCLUDING OPTICAL MICROSCOPE - An information processing apparatus includes an acquisition section and a correction section. The acquisition section acquires information of lightness distribution of a first image captured by an imaging section capable of capturing an image of an observed area provided on an optical path of an optical system of an optical microscope, the image of the observed area being obtained by the optical microscope, the first image being an image of the observed area in a state where no sample is placed therein, the lightness distribution resulting from the optical system of the optical microscope. The correction section corrects, based on the information of lightness distribution acquired by the acquisition section, lightness unevenness of a second image captured by the imaging section, the second image being an image of the observed area in a state where the sample is placed therein. | 09-12-2013 |
20130242078 | MICROSCOPE - A microscope is provided. The microscope includes: a detection section for detecting the measurement light; a first image acquisition section emitting the visible light onto a detection surface to obtain an optical image; and a switch mirror or beam splitter disposed on a light path, along which the measurement light from the analysis position of the sample is guided to the detection section. The microscope further includes a second image acquisition section that is disposed in a position apart from the light path of the detection section for obtaining an optical image of a large area which includes the analysis position of the sample, wherein the optical image of the large area is larger than an optical image of an area, which includes the analysis position of the sample, obtained by the first image acquisition section. | 09-19-2013 |
20130250088 | MULTI-COLOR CONFOCAL MICROSCOPE AND IMAGING METHODS - A confocal microscope, which comprises a light source for producing excitation light including a plurality of different spectral components; an optical device for providing the excitation light as a spectrally dispersed beam and outputting the different spectral components as a number of elongated beams an object holder for holding an object; an objective for focusing the elongated beams of light on the object as parallel, spaced-apart lines of excitation light corresponding to the different spectral components; and a detector for simultaneously detecting emission light produced by parallel lines emitted by the object due to its illumination by spaced apart parallel lines of the excitation light. | 09-26-2013 |
20130250089 | DEVICE AND METHOD FOR OPTIMIZING DETERMINING RECORDING REGIONS - A device for establishing one or several recording regions from an image region is provided. The device includes a neighborhood determining unit for determining whether two objects of the image region are neighboring. Additionally, the device includes a graph set determining unit for determining a graph set such that the graph set includes one or several complete graphs, each element of the complete graph being neighboring to every other element of this complete graph. Furthermore, the device includes a selection set determining unit configured to add a complete graph to the selection set when one of the elements of an object set is included by precisely this one of the complete graphs of the graph set. In addition, the device includes a recording region determining unit for determining the one or several recording regions based on the complete graphs of the selection set. | 09-26-2013 |
20130250090 | METHOD OF PREPARING BIOLOGICAL SPECIMEN - A sufficient amount of biological molecules are collected from a desired region in a tissue section with a single operation. Provided is a method of preparing a biological specimen including a sectioning step of sectioning biological tissue along a single cutting plane; a staining step of staining a first tissue section of two tissue sections that have been sectioned in the sectioning step; a stained-image capturing step of acquiring a stained image of the stained tissue section; a non-stained-image capturing step of acquiring a non-stained image in which, with respect to a second tissue section that has been sectioned in the sectioning step, division lines that divide the tissue section into a plurality of segments are defined; and associating steps of associating the non-stained image and the stained image with each other. | 09-26-2013 |
20130258090 | Light microscope and method for recording images with a light microscope - The invention relates to a method for recording images with a light microscope, wherein a specimen container with a specimen is arranged on a specimen holder of the light microscope, and wherein illuminating light is guided onto the specimen. The illuminating light can hereby be cut in a cross-section transversely to an optical axis of the light microscope through a wall of the specimen container to a limited cross-sectional region. First and second diaphragm settings are determined and set, for the limited cross-sectional region of the illuminating light defined by the wall of the specimen container, in which the diaphragm covers equal sized portions of the limited cross-sectional region. In addition the invention relates to a light microscope which is adapted in particular to carry out the method. | 10-03-2013 |
20130258091 | METHOD AND DEVICE FOR HOLOGRAPHIC OPTO-FLUIDIC MICROSCOPY - A method and system of imaging a moving object within a microfluidic environment includes illuminating a first side of a flow cell configured to carry the moving object within a flow of carrier fluid with an illumination source emitting at least partially coherent light, the at least partially coherent light passing through an aperture prior to illuminating the flow cell. A plurality of lower resolution frame images of the moving object are acquired with an image sensor disposed on an opposing side of the flow cell, wherein the image sensor is angled relative to a direction of flow of the moving object within the carrier fluid. A higher resolution image is reconstructed of the moving object based at least in part on the plurality of lower resolution frame images. | 10-03-2013 |
20130265405 | Visualizing Polynuclear Aromatic Hydrocarbons within the Near Infrared Spectrum - Microscopy techniques may be used to visualize polynuclear aromatic hydrocarbons where an optical microscope is combined with an imaging device. The combination of these devices allows for images to be produced when visualized in the near infrared spectrum, such as a wavelength ranging from about 700 nm to about 2500 nm to be passed through the optical microscope. | 10-10-2013 |
20130265406 | MICROSCOPE SYSTEM, IMAGE PROCESSING APPARATUS, AND COMPUTER READABLE RECORDING MEDIUM - A microscope system includes: a microscope that generates an observation image of a specimen; an image obtaining unit that obtains an RGB image of the specimen; a spectroscopic information obtaining unit that obtains spectroscopic information of the specimen; an analyzer that analyzes the RGB image; a determining unit that determines a necessity of obtaining the spectroscopic information based on a result of the analysis of the analyzer; and a control unit that controls an operation of the spectroscopic information obtaining unit based on a result of the determination of the determining unit. | 10-10-2013 |
20130271592 | HIGH-SPEED WAVEFRONT OPTIMIZATION - A wavefront is optimized imaging a sample. A binary off-axis hologram is encoded by selective adoption of states for each mirror of a deformable mirror device, which is illuminated with an incident beam of light. A single diffraction order that has encoded phase-mask information is selected from light reflected from the deformable mirror device and focused onto the sample. Light scattered from the sample is directed to a photodetector. A transmission matrix through the sample is calculated from light received by the photodetector. | 10-17-2013 |
20130271593 | IMAGE PROCESSING APPARATUS, IMAGE DISPLAY SYSTEM, AND IMAGE PROCESSING METHOD AND PROGRAM - There is provided an image processing apparatus which can prevent the case where it is difficult to perform highly accurate diagnosis using combined boundary regions in a combined image. | 10-17-2013 |
20130271594 | ACHIEVING FOCUS IN A DIGITAL PATHOLOGY SYSTEM - Methods and apparatus are provided for computing focus information during scanning digital microscope slide data with a line scan camera. The systems and methods include a dynamically interleaved procedure that works by moving the specimen relative to the objective lens while the height of the objective lens is adjusted relative to the stage. Imagery data is acquired at a plurality of objective lens heights the image data from the objective lens height having maximum contrast is stored and combined into a composite digital image of at least a portion of the specimen. | 10-17-2013 |
20130278742 | METHOD OF OBSERVATION OF THE EMISSION OF LIGHT FROM A SAMPLE BY DYNAMIC OPTICAL MICROSCOPY - Method for observing an emission of light from a sample in a medium of refractive index nL disposed against a surface of a transparent support of refractive index nS, greater than nL, the emission of light comprising luminous components oriented toward the support and forming an angle θ and including supercritical luminous components and critical or subcritical luminous components, implementing an observation device applying filters to the signal; and transforming the signal into an image zone of the sample Modulation of the signal is carried out, in which components of the emission of light are allowed to pass through so as to obtain image zones, the modulation pertaining to all or some of the collected signals; and at least one useful image zone of the sample is produced by combining image zones, the combination evidencing differences between the image zones related to the modulation. | 10-24-2013 |
20130278743 | METHOD AND SYSEM FOR MEASURING POROSITY OF PARTICLES - A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium. | 10-24-2013 |
20130278744 | METHOD AND SYSTEM FOR CALIBRATING A SPATIAL OPTICAL MODULATOR IN AN OPTICAL MICROSCOPE - A method and system for calibrating an optical device having a spatial optical modulator ( | 10-24-2013 |
20130286180 | TIME RESOLVED OPTICAL MICROSCOPY ("TROM") PROCESS FOR MEASURING THE RATE OF CRYSTALLIZATION OF SOLID INKS - A system is disclosed for measuring the crystallization of crystalline-amorphous mixtures. The system includes a sample holder. and a heating apparatus to melt a ink composition and to keep the melted ink composition at a first specified temperature for a first period of time. The system includes a cooling apparatus to receive the melted ink composition, to cool the melted ink composition and to maintain the cooled ink composition at a second specified temperature. The system includes a microscope and a video recording device to capture images of the cooled ink composition for a second period of time A video processing computer includes a memory, a processor and software instructions and the software instructions causes the computer to extract crystallization parameters about the cooled ink composition from the captured images. The crystallization parameters identify fast solidifying crystalline inks that have a short time duration from onset of crystallization until crystallization. | 10-31-2013 |
20130286181 | STRUCTURED PLANE ILLUMINATION MICROSCOPY - An apparatus includes a light source configured for generating a coherent light beam having a wavelength, λ, a light detector, and beam-forming optics configured for receiving the generated light beam and for generating a plurality of substantially parallel Bessel-like beams directed into a sample in a first direction. Each of the Bessel-like beams has a fixed phase relative to the other Bessel-like beams. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beams and for imaging the received light onto the detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction, where the detector is configured for detecting light received by the imaging optics. A processor configured to generate an image of the sample based on the detected light. | 10-31-2013 |
20130286182 | FOCUS POSITION MAINTAINING APPARATUS, AND MICROSCOPE - A focus position maintaining apparatus and a microscope are provided. The focus position maintaining apparatus can three-dimensionally correct a shift of a specimen in real time to maintain the focal point of an objective lens in a desired position in the specimen, and the microscope includes the focus position maintaining apparatus. The focus position maintaining apparatus includes a microlens array having a plurality of unit lenses and disposed in a position where the microlens array receives light from a specimen via an objective lens, a focus imaging device disposed in a position where the focus imaging device receives light from the unit lenses of the microlens array, and a control unit that outputs a signal for controlling operation of a focus actuator based on image formation positions of a plurality of images of the specimen detected by the focus imaging device via the microlens array. | 10-31-2013 |
20130293695 | VARIABLE FOCUSING OF ELECTRON MICROSCOPY IMAGE DATA UTILIZING ORIGIN-CENTERED DISCRETE FRACTIONAL FOURIER TRANSFORM - Computer-implemented arrangements for adjusting the focus in original electron microscope image data are described. In an implementation, an origin-centered fractional Fourier transform operation and an origin-centered phase restoration operation, both responsive to a provided fractional power value, are collectively applied to original electron microscope image data to produce computationally-focused image data. A parameter adjuster is used to provide a range of variation of the power value, and can be adjusted by a user or under the direction of a control system. The fractional Fourier transform operation and the phase restoration operation can be realized by at least one numerical algorithm and can comprise an approximation. | 11-07-2013 |
20130293696 | IMAGE CONTROL SYSTEM AND METHOD THEREOF - An image control system is provided in this application. The image control system includes an object imaging device, a control module, a viewing module and a hosting service of image sharing and management module. The present application further provides a method for image control which includes an image/audio sharing step, an image controlling step, an image/audio capturing step, an image/audio storing step, and an image analyzing and management step. Multiple users may view or control the images captured by the control module concurrently and remotely through the present application and may set different image processing modes according to the user needs. | 11-07-2013 |
20130293697 | MINIATURE MICROSCOPE AND MANUFACTURING METHOD OF OPTICAL ELEMENT THEREOF - A manufacturing method of an optical element applied to a miniature microscope comprises the steps of: emitting a signal light and a reference light to an optical material; and forming a plurality of gratings on the optical material by interfering the signal light and the reference light. A miniature microscope is also disclosed. | 11-07-2013 |
20130293698 | MICROSCOPE SYSTEM - The present microscope system has: a microscope, which has a light source, an aperture stop, a condenser lens, and an objective lens; a camera, which has a microlens array and an image pickup element; and an image processing unit, which constitutes a computer. The image processing unit divides a plurality of pixels allocated to each of the microlenses into bright-field image detection regions to be used for detecting bright-field images, and dark-field image detection regions to be used for detecting darkfield images, in accordance with the size of an aperture of the aperture stop. The image processing unit generates bright-field image data of a sample and darkfield image data of the sample. | 11-07-2013 |
20130300853 | SYSTEMS AND METHODS FOR CAMERA-BASED IMAGE PROCESSING IN MICROSCOPY INSTRUMENTS - Systems and methods for executing super-resolution microscopy of a specimen with most of the image processing performed in a camera of a fluorescence microscopy instrument are described. In one aspect, the camera includes one or more processors to execute machine-readable instructions that control excitation light output from a multi-channel light source, control capture of intermediate images of the specimen, and perform image processing of the intermediate images to produce a final super-resolution image of the specimen. | 11-14-2013 |
20130307957 | Scanning Microscope Having an Adaptive Scan - A method of using a scanning microscope to rapidly form a digital image of an area. The method includes performing an initial set of scans to form a guide pixel set for the area and using the guide pixel set to identify regions representing structures of interest in the area. Then, performing additional scans of the regions representing structures of interest, to gather further data to further evaluate pixels in the regions, and not scanning elsewhere in the area. | 11-21-2013 |
20130307958 | CIRCUIT AND METHOD FOR CONTROLLING A MICROSCOPE - A circuit for controlling a microscope using a controller includes a slow memory configured to store control information. The controller is configured to control microscope parameters based on the control information. The circuit includes a data loader and at least two fast memories. The data loader is configured such that control information is written from the slow memory alternately into one of the at least two fast memories. The circuit also includes a multiplexer configured to permit access by the controller to one of the at least two fast memories in alternating fashion so as to read control information. The data loader is configured to control the multiplexer in such a way that a write operation by the data loader and a read operation by the controller will not occur simultaneously on the same fast memory. | 11-21-2013 |
20130307959 | LASER SCANNING MICROSCOPE AND ITS OPERATING METHOD - Laser scanning microscope and its operating method in which at least two first and second light distributions activated independently of each other and that can move in at least one direction illuminate a sample with the help of a beam-combining element, and the light is detected by the sample as it comes in, characterized by the fact that the scanning fields created by the light distributions on the sample are made to overlap mutually such that a reference pattern is created on the sample with one of the light distributions, which is then captured and used to create the overlap with the help of the second light distribution (correction values are determined) and/or a reference pattern arranged in the sample plane or in an intermediate image plane is captured by both scanning fields and used to create the overlap (correction values are determined) and/or structural characteristics of the sample are captured by the two scanning fields as reference pattern and used to create the overlap in which correction values are determined. | 11-21-2013 |
20130314526 | CELL ANALYSIS DEVICE - Provided is a cell concentration/purification device having a function of successively locating cells in a specific area of a microchannel, and a function of sequentially capturing cell images by use of light from a plurality of monochromatic light sources on an image basis, and performing comparative analysis of the cell images to recognize individual cells based on information on the shape of the cells and an absorption spectral distribution of the cells or inside of the cells, thereby selectively separating/purifying the cells. | 11-28-2013 |
20130314527 | IMAGE PICKUP METHOD AND IMAGE PICKUP APPARATUS - An image pickup method includes dividing a surface shape of an object into a plurality of areas, approximating a surface of each of the plurality of areas to a plane, and calculating a slope of the plane, grouping the plurality of areas into m groups so that slopes of planes corresponding to the areas belonging to the same group fall within a permissible range, tilting a stage configured to hold the object so that all slopes of planes belonging to a group k of the m groups can fall within a depth of focus where k is an integer selected from 1 to m, making image sensors corresponding to the areas belonging to the group k among the plurality of image sensors, capture images of the object, and repeating tilting and caputing from k=1 to k=m. | 11-28-2013 |
20130314528 | SYSTEM AND METHOD OF MULTITECHNIQUE IMAGING FOR THE CHEMICAL BIOLOGICAL OR BIOCHEMICAL ANALYSIS OF A SAMPLE - The invention substantially relates to an imaging system for the chemical, biological or biochemical analysis of a sample ( | 11-28-2013 |
20130321609 | MICROSCOPE AND METHOD FOR CHARACTERIZING STRUCTURES ON AN OBJECT - A microscope includes an illumination unit for illuminating a mask at a predetermined non-axial illumination angle, an imaging unit for imaging an aerial image of the mask within a predetermined defocus region, and an imaging field stop, in which as a result of the lateral displacement of the aerial image depending on the position within the defocus region and on the non-axial illumination angle, the opening of the imaging field stop is dimensioned such that the aerial image is either completely encompassed or circumferentially cut within the defocus region. | 12-05-2013 |
20130329033 | MICROSCOPE SYSTEM - A microscope system comprises: a stage carrying a sample; an optical system forming an sample image; a driver driving at least the optical system or stage to relatively moves the sample and optical system; an imaging section capturing a reference viewing field image as an image of a predetermined viewing field range of the sample and peripheral viewing field images each being an image of a peripheral viewing field range containing a predetermined region in the predetermined viewing field range and different from the predetermined viewing field range, by the driver moving the relative position of the sample; a correction gain calculator calculating a correction gain of each pixel of the reference viewing field image based on the reference viewing field image and peripheral viewing field image; and a corrector performing shading correction on the reference viewing field image based on the calculated correction gain. | 12-12-2013 |
20130329034 | DEFOCUS AMOUNT ESTIMATION METHOD, IMAGING APPARATUS, AND TRANSPARENT MEMBER - A defocus amount estimation method for an imaging apparatus that captures, using an image sensor, an image of a specimen formed by an imaging optical system includes a captured image evaluation step of fixing the specimen using a transparent member including a mark that applies at least one of a phase variation and an amplitude change to transmitted light, to acquire a captured image containing an image of the specimen and an image of the mark, and an estimation step of estimating a defocus amount based on the captured image. | 12-12-2013 |
20130335548 | QUANTITATIVE PHASE MICROSCOPY FOR HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT - Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei. | 12-19-2013 |
20130342673 | METHOD AND DEVICE FOR FOCUSSING A MICROSCOPE AUTOMATICALLY - A method for automatic focusing of a microscope with a microscope objective on a selected area of a specimen, in which a digital hologram of the selected area of the specimen is generated in an off-axis mode and a microscope with which the method is implemented. The digital hologram is used to determine, on the optical axis of the microscope objective, a focus position to be set in which the selected area of the specimen is optimally in focus. Subsequently, a control system is used to set the microscope to the focus position determined and thus is focused on the area selected. | 12-26-2013 |
20130342674 | Pathology Slide Scanners For Fluorescence And Brightfield Imaging And Method Of Operation - An instrument for scanning a specimen has a two-dimensional sensor array, the sensor array containing a mosaic colour filter array or a scanning colour filter array. The instrument can be operated in fluorescence or in brightfield. The scanning colour filter array has the same colour throughout each row with adjacent rows having different colours. | 12-26-2013 |
20130342675 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING SYSTEM, AND INFORMATION PROCESSING METHOD - An information processing apparatus includes a storage unit and an output unit. The storage unit is capable of storing an image of a slide including both images of a sample and a label, which are obtained by shooting the slide. The slide holds the sample and has a front surface on which the label indicating label information relating to the sample is provided. The output unit is capable of outputting the image of the slide as a thumbnail image. | 12-26-2013 |
20140015953 | COMPACT MICROSCOPY SYSTEM AND METHOD - There is disclosed an apparatus for magnifying and capturing images of one or more samples, as well as an apparatus for changing objective lenses. Methods of using the apparatuses, and other embodiments, are also disclosed. | 01-16-2014 |
20140015954 | IMAGE PROCESSING APPARATUS, IMAGE PROCESSING SYSTEM, IMAGE PROCESSING METHOD, AND IMAGE PROCESSING PROGRAM - An image processing apparatus which processes virtual slide image data to be displayed in an image display apparatus includes an image data obtaining unit which obtains image data obtained by capturing an image of a target object, and an image data generation unit which generates display image data corresponding to the image of the target object to be displayed in the image display apparatus in a display magnification corresponding to a predetermined field number of a microscope. | 01-16-2014 |
20140015955 | PROBE APPARATUS - The present invention generally relates to methods and apparatuses for ensuring the integrity of probe card assemblies, verifying that probe cards are ready for testing, and allowing analysis of probe card performance characteristics. In one embodiment, an apparatus allows rework of a probe card at an angle from a front position of the apparatus. | 01-16-2014 |
20140022373 | CORRELATIVE DRIFT CORRECTION - A correlative drift correction system can include a sample stage for supporting a sample and a cover slip. The system can include an infrared light source for emitting infrared light to be reflected at the cover slip and an optical sensor for detecting the reflected infrared light. The system can detect drift of the sample using reflected infrared light data from the optical sensor and can determine a drift correction to apply to image data of the sample. | 01-23-2014 |
20140028828 | Ion Beam Sample Preparation Apparatus and Methods - Disclosed are embodiments of an ion beam sample preparation apparatus and methods. The methods operate on a sample disposed in a vacuum chamber and include steps of directing an intensity-controllable, tilt-angle controllable ion beam at a sample holder coupled to a rotation stage. The methods further include illuminating and capturing one or more images of the sample, extracting useful features from one or more images and thereafter adjusting the sample preparation steps. Further methods are disclosed for capturing sequences of images, programmatically rotating images, and displaying sequences of images with similar rotation angles. Further methods include extracting useful features from sequences of images that may change with respect to time as ion beam preparation continues. | 01-30-2014 |
20140036057 | SAMPLE OBSERVATION DEVICE FOR GENERATING SUPER RESOLUTION IMAGE - A sample observation device includes: an excitation light generation unit; an intermediate image forming unit projecting excitation light to a sample and forming an intermediate image of the sample at an intermediate image position with observing light; a confocal modulation unit modulating spatial intensity distributions of the excitation light and the intermediate image at the position; a modulation drive unit moving a pattern of the modulation unit; an image relay unit relaying on a image forming surface the intermediate image; an image pickup unit converting the distribution of relayed intermediate image into digital image data; and an image processing unit processing on the digital image data. Cutoff frequency of the relay unit and Nyquist frequency of the pickup unit exceed cutoff frequency of the forming unit, and the processing unit performs a high frequency enhancing process for enhancing the high frequency component exceeding the cutoff frequency of the forming unit. | 02-06-2014 |
20140043460 | OPTICAL ARRANGEMENT - The present disclosure relates to an improved optical arrangement for an optical imaging system or the like, comprising: an optical device; a digital micromirror device having a plurality of individually addressable micromirrors; a convex mirror; and a concave mirror concentric to the convex mirror. The convex mirror and the concave mirror define an optical triplet which is located in an optical path with the digital micromirror device and the optical device. The concave mirror comprises two concave mirror sections, one or both concave mirror sections being moveable relative to the convex mirror so as to control an image mapping between the digital micromirror device and the optical device. | 02-13-2014 |
20140043461 | IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, IMAGE PROCESSING PROGRAM, AND VIRTUAL MICROSCOPE SYSTEM - An image processing device for processing a stained sample image including hematoxylin stain is provided with a dye spectrum storage unit that stores a dye spectrum of dye used in staining, a change characteristic calculation unit that calculates a change characteristic in a wavelength direction of the dye spectrum based on the dye spectrum, a dye amount/wavelength shift amount estimation unit that estimates at least a dye amount of the hematoxylin stain and a shift amount in the wavelength direction for each pixel in the stained sample image based on the dye spectrum and the change characteristic; and a cell nucleus extraction unit that extracts a cell nucleus region of the stained sample image based on the shift amount estimated in the wavelength direction. | 02-13-2014 |
20140049630 | DICHROIC IMAGE SPLITTER - An optical image splitter disposed in the path of image-bearing light along an optical axis has a coated dichroic surface disposed at an angle of 15 degrees or less relative to incident light along the optical axis. The coated dichroic surface has a number of layers of material, the of layers including layers having a first refractive index, n | 02-20-2014 |
20140049631 | MICROSCOPY IMAGING STRUCTURE WITH PHASE CONJUGATED MIRROR AND THE METHOD THEREOF - The present invention discloses a microscopy imaging structure with phase conjugated mirror and the method thereof. The afore-mentioned imaging structure produces a reverse focusing conjugated probe beam together with an original probe beam. These two probe beams meet at the focal point in the object body to be probed, and an interference pattern is produced. The interval between any two consecutive wave fronts in the interference pattern is then half of the wavelength of the original probe beam, and hence the vertical resolution of the image is improved. The present invention also applies a light modulator module on the probe beam to easily adjust the depth of the focal point of the probe beam and the phase conjugated reverse focusing probe beam in the object body. With the adoption of this invention, the size or position limitation of the target object is eliminated and the imaging resolution is also improved. | 02-20-2014 |
20140049632 | SYSTEMS AND METHODS FOR IMAGING TISSUE - Method and system for imaging tissue, including (i) causing a macroscopic image of a tissue surface to be displayed on a visual display; (ii) receiving a selection of at least one portion of the macroscopic image; (iii) causing a plurality of confocal images captured by a confocal imager at different depths in a portion of the tissue to be displayed; (iv) receiving a selection of at least one target depth image; and (v) for each selected target depth image, instructing the confocal imager to capture a plurality of additional images at different locations and at a common depth with the target depth image. A system for imaging tissue having a macroscopic display module; a first selection module; a confocal display module; a second selection module; and an instruction module for instructing a confocal imager to capture a plurality of images at different locations over a selected region of the tissue. | 02-20-2014 |
20140049633 | IMAGING SYSTEM AND IMAGING METHOD - An imaging system with an imaging lens system for imaging an object into an image plane is disclosed. The imaging lens system contains an optical component for a higher depth of field, of which the refractive power is alterable and the optical effect remains rotation-symmetrical. | 02-20-2014 |
20140049634 | SYSTEM AND METHOD FOR REMOTE CONTROL OF A MICROSCOPE - A system and method for remote control of an automated microscope via a widely distributed network. | 02-20-2014 |
20140055592 | SYSTEM AND APPARATUS FOR COLOR CORRECTION IN TRANSMISSION-MICROSCOPE SLIDES - The present invention concerns a system and method for calibration and adjustment of the pixel color values represented within a digital image of a sample by a transmission microscope. Furthermore the present invention is directed to providing sufficient color information in order to generate a color mapping matrix that allows for the creation of a synthetic image to depict the sample under a desired illumination. The system and method provides a solution that generates a destination-device independent image that is configurable to any calibrated display device. | 02-27-2014 |
20140055593 | TEST SAMPLE DEVICE AND TEST METHOD FOR AN OPTICAL MICROSCOPE WITH SUBWAVELENGTH RESOLUTION - A test sample device for an optical microscope which images a sample in different light states with a local resolution in the subwavelength range of the visible spectral range, wherein the test sample device comprises: a test piece, which is designed to be microexamined with the microscope and has a surface on which nanostructures are arranged, wherein each nanostructure, viewed along the surface, has a dimension in the subwavelength range, wherein the nanostructures are spaced apart from one another by an amount which lies above the wavelength of the visible spectral range, and wherein the nanostructures are switchable collectively between a bright state, in which they illuminate, and a dark state, in which they do not illuminate, and a drive, which is designed to move the test piece in the subwavelength range, whereby the different light states can be realized by different movement states of the test piece. | 02-27-2014 |
20140055594 | STRUCTURED ILLUMINATING MICROSCOPY AND STRUCTURED ILLUMINATING OBSERVATION METHOD - In order to realize a high-speed switching of structured pattern, a structured illuminating microscopy includes a driving unit generating a sonic standing wave in a sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to a light modulator, an illuminating optical system making at least three diffracted components of the exit light flux passed through the sonic wave propagation path to be interfered with one another, and forming interference fringes on an observational object, an image-forming optical system forming an image by an observational light flux from the observational object on a detector, and a controlling unit controlling a contrast of an image by modulating at least one of an intensity of the exit light flux, an intensity of the observational light flux, and the detector with a modulating signal of 1/N frequency of the driving signal. | 02-27-2014 |
20140063222 | AUTOMATIC MICROSCOPIC FOCUS SYSTEM AND METHOD FOR ANALYSIS OF TRANSPARENT OR LOW CONTRAST SPECIMENS - A microscope system and method empirically determines the boundaries of the depth of field of an objective lens. The system and method are largely automated, with the manipulation of a specimen to be imaged being carried out by processors and associated equipment. Calculations of the empirical depth of field are also likewise automated. Upon empirically determining the boundaries of the depth of field, the specimen, particularly when transparent or translucent, can be accurately imaged at user-defined depths smaller than the depth of field. | 03-06-2014 |
20140063223 | UNDERWATER HYPERSPECTRAL IMAGING - An apparatus for placement on or in a body of water for hyperspectral imaging of material in the water comprises an artificial light source and a hyperspectral imager. These are arranged so that in use light exits the apparatus beneath the surface of the water and is reflected by said material before re-entering the apparatus beneath the surface of the water and entering the hyperspectral imager. The hyperspectral imager is adapted to produce hyperspectral image data having at least two spatial dimensions. | 03-06-2014 |
20140063224 | IMAGE-PICKUP OPTICAL SYSTEM, IMAGE-PICKUP APPARATUS, AND IMAGE-PICKUP SYSTEM - An image-pickup optical system includes a primary imaging optical system configured to form an image of an object, a secondary imaging optical system configured to re-form an image of the object, and a driver configured to drive an optical element included in the secondary imaging optical system and to change an aberration. | 03-06-2014 |
20140063225 | MOTION-COMPENSATED CONFOCAL MICROSCOPE - A motion-compensated confocal microscope includes a laser scanning system, a fiber-optic component having a proximal end and a distal end such that the fiber-optic component is optically coupled to the laser scanning system to receive illumination light at the proximal end and to emit at least a portion of the illumination light at the distal end, and a detection system configured to receive and detect light returned from a specimen being observed and to output an image signal. The light returned from the specimen is received by the distal end of the fiber-optic component and transmitted back and out the proximal end of the fiber-optic component. The motion-compensated confocal microscope also includes a motion compensation system connected to at least one of the distal end of the fiber-optic component or to the specimen to move at least one of the distal end of the fiber-optic component or the specimen to compensate for relative motion between the distal end of the fiber-optic component and a portion of the specimen being observed. | 03-06-2014 |
20140071260 | DIGITAL CONFOCAL OPTICAL PROFILE MICROSCOPY - Various embodiments of microscopy systems, devices, and associated methods of analysis are described herein. In one embodiment, a method of operating a microscope includes acquiring a profile of a light signal from a sample with a photo detector without passing the light signal through a physical pinhole. The method also includes determining a parameter of the sample based on generally the entire acquired profile of the light signal. | 03-13-2014 |
20140071261 | ABERRATION ESTIMATING METHOD, PROGRAM, AND IMAGE-PICKUP APPARATUS - An aberration estimating method using a steepest descent method is configured to estimate, as an aberration of a test optical system, an aberration when a predetermined evaluation function becomes less than or equal to a permissible value. The aberration estimating method comprising the step of updating the aberration with a sum of a current aberration and a first derivative of the evaluation function by the aberration when the evaluation function is larger than the permissible value. The aberration is an aberration of an entire pupil plane of the test optical system. The updating step includes calculating the first derivative by Fourier-transforming the difference instead of an integration at coordinates of respective points on an image plane of the test optical system. | 03-13-2014 |
20140071262 | IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION SYSTEM - An image acquisition apparatus includes: an imaging optical system configured to capture an image of an object; a plurality of re-imaging optical systems configured to re-image the object imaged by the imaging optical system; a reflecting optical system arranged on an optical path between the imaging optical system and the plurality of re-imaging optical systems; and a plurality of image-pickup elements configured to capture an image of the object re-imaged by the plurality of re-imaging optical systems. At least one of the plurality of image pickup elements is arranged in a plane different from a plane in which other image pickup elements are arranged; and the plurality of image-pickup elements are respectively capable of changing at least one of the positions in the direction of an optical axes of the corresponding re-imaging optical systems and the inclinations with respect to the optical axes on the basis of shape information of the object. | 03-13-2014 |
20140071263 | METHOD AND DEVICE FOR NON-CONTACT MEASURING SURFACES - A slit m is projected onto an object surface in which reference point X | 03-13-2014 |
20140078285 | IMAGING APPARATUS AND MICROSCOPE SYSTEM HAVING THE SAME - Disclosed is an imaging apparatus including: a spectroscopic measurement section configured to measure a spectral characteristic of a subject; a spectral image capture section configured to capture a subject image separated into a plurality of colors through color separation to create a plurality of spectral images; and a color separation characteristic determining section configured to determine a color separation characteristic to be used for image capturing of the spectral image capture section, based on the spectral characteristic of the subject measured by the spectroscopic measurement section. The color separation characteristic determining section determines a count of color separations in the image capturing of the spectral image capture section and spectral bands corresponding to each of the color separations. | 03-20-2014 |
20140078286 | METHOD AND SYSTEM FOR SPECTRAL UNMIXING OF TISSUE IMAGES - A method and system for spectral demultiplexing of fluorescent species, such as quantum dots, conjugated with a biological tissue. The process of demultiplexing involves a non-liner regression based on curve-fitting of estimated spectra of the quantum dots and confidence intervals describing the parameters of such fitting curve for typical quantum dots. | 03-20-2014 |
20140085453 | IMAGE DISPLAY DEVICE AND IMAGE DISPLAY SYSTEM - There is provided an image display device including a display control unit having a display combining unit that displays one or a plurality of pathological index cursors based on information relating to a pathological slide image. | 03-27-2014 |
20140092228 | IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, AND IMAGE PROCESSING SYSTEM - An image processing device sets a determination target area based on a pixel to a taken image for each of a plurality of pixels included in a pixel group obtained as a candidate of a nucleus of a target cell, and determines whether or not the target cell is included in the determination target area, which is set by the setting section for each of the plurality of pixels included in the pixel group, based on whether or not an image feature amount obtained from the determination target area satisfies a condition of the image feature amount of the target cell. | 04-03-2014 |
20140092229 | SMALL-PROFILE LENSLESS OPTICAL MICROSCOPY IMAGING AND TOMOGRAPHY INSTRUMENTS AND ELEMENTS FOR LOW COST AND INTEGRATED MICROSCOPY - Arrangements for small-sized, inexpensive, and innovative lensless and other micro-optic microscopy imaging and tomography are presented. An imaging region comprising flat or curved surfaces is provided with an illumination source proximate to the imaging region or arranged for collimated illumination. Light travels through the imaging region and produces a resulting light field affected by objects, materials, fluids, organisms, etc. in the light path and is presented to an image sensing surface proximate to the imaging region, responsively creating electrical image signals. The illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET whose illumination can be sequenced in an image formation or tomography process. Light-emission and light detection elements can be printed, permitting extremely low-cost manufacturing and readily accommodating imaging regions having curved shapes. Applications include laboratory instruments, micro-arrays, microplates, flow microscopes, cytometry systems, environmental and contamination monitoring systems, industrial monitoring instruments, food safety systems, and implants. | 04-03-2014 |
20140098211 | SYSTEM, METHOD AND COMPUTED READABLE MEDIUM FOR EVALUATING A PARAMETER OF A FEATURE HAVING NANO-METRIC DIMENSIONS - A non-transitory computer readable medium, a system and a method. The method may include obtaining, by an image obtaining module, an image of a measurement site, the measurement site comprise the feature, the image of the measurement site comprises an image of the feature; processing, by an image processor, the image of the measurement site to provide an artificial image, the artificial image comprise a artificial image of an artificial feature, the artificial feature differs from the feature; measuring a parameter of the artificial feature to provide a measurement result, wherein the measuring comprises applying a measurement algorithm that is inadequate for measuring the parameter of the feature; and determining a value of the parameter of the feature in response to the measurement result. | 04-10-2014 |
20140098212 | IMAGE CAPTURING DEVICE AND IMAGE CAPTURING SYSTEM - An image capturing device and an image capturing system are provided. The image capturing device includes an optical system that focuses lights from an object to generate optical information, a filter provided near a diaphragm position of the optical system, the filter having a plurality of types of spectral characteristics, a sensor that converts the optical information of the object to electronic data, the sensor providing a plurality of spectral transmittance values that sequentially and spatially change, and a lens array having a plurality of lenses being arranged in substantially parallel in a direction of a two-dimensional surface of the sensor. | 04-10-2014 |
20140098213 | IMAGING SYSTEM AND CONTROL METHOD FOR SAME - An imaging system according to the present invention comprises: an imaging unit configured to acquire a plurality of images by imaging an object a plurality of times while changing a focusing position in an optical axis direction of an imaging optical system; and a generation unit configured to generate, on the basis of the plurality of images acquired by the imaging unit, an image at arbitrary depth of field or an image of the object viewed from an arbitrary viewing direction. The image acquired by the imaging unit sometimes includes fixed pattern noises that appear in fixed positions. The imaging unit images the object a plurality of times while changing a position or an orientation of an imaging region such that relative positions of the fixed pattern noises to the object vary among the plurality of images. | 04-10-2014 |
20140098214 | METHOD FOR DEFINING A LASER MICRODISSECTION REGION, AND ASSOCIATED LASER MICRODISSECTION SYSTEM - A method for laser microdissection of a laser microdissection region of a prepared specimen includes driving a holder for the specimen into a holding position using a control device. First and second digital images are captured that depict a same portion of the prepared specimen, with the first image depicting the portion under at least one first microscopic examination method and the second image depicting the portion under at least a second microscopic examination method. A live overlay image is generated of the portion of the prepared image in a live mode. The live overlay is presented on a display area with the images overlaid onto one another. A marking is generated and captured on the live overlay image so as to define the laser microdissection region. | 04-10-2014 |
20140104407 | STRUCTURED ILLUMINATION OPTICAL SYSTEM AND STRUCTURED ILLUMINATION MICROSCOPE DEVICE - An illumination optical system includes: a beam splitter located near a conjugate position of a specimen and configured to split beams from a light source into a plurality of groups of beams having different splitting directions around an optical axis; a beam selector configured to select and transmit one group of beams from the plurality of groups of beams and that is rotatable with respect to the optical axis; and a ½ wavelength plate located near the beam selector and rotatable about the optical axis. The rotation angles of the ½ wavelength plate and of the beam selector about the optical axis are respectively set so that the polarization direction of the beam which has passed through the ½ wavelength plate is perpendicular to the splitting direction of the one group of beams that has been selected by the beam selector and split by the beam splitter. | 04-17-2014 |
20140111633 | WIDE FIELD MICROSCOPE AND METHOD FOR WIDE FIELD MICROSCOPY - A method for high-resolution PAL microscopy, wherein a sample field is imaged on a detector surface of a detector, the sample field is imaged into an image field which is smaller than the detector surface, and the image field on the detector surface is shifted, so that the same sample field is imaged in different positions located adjacent to one another on the image field in order to determine information about changes in the sample field. | 04-24-2014 |
20140118524 | Method And Apparatus For The Imaging Of A Labeled Biological Sample - A method and apparatus for the imaging of a labeled biological sample. The method comprises illuminating the labeled biological sample, generating members of a time series of images if the labeled biological sample, generating a plurality of difference images between later members of the time series of images of earlier members of the time series of images and combining the plurality of difference images to generate a final image of the labeled biological sample. | 05-01-2014 |
20140118525 | Systems, Devices, and Methods Employing Angular-Resolved Scattering and Spectrally Resolved Measurements for Classification of Objects - Systems, devices, and methods are described for identifying, classifying, differentiating, etc., objects. For example a hyperspectral imaging system can include a dark-field module operably coupled to at least one of an optical assembly, a dark-field illuminator, and a hyperspectral imaging module. The dark-field module can include circuitry having one or more sensors operable to acquire one or more dark-field micrographs associated with scattered electromagnetic energy from an object interrogated by the dark-field interrogation stimulus. The hyperspectral imaging module can be operably coupled to the dark-field module, and can include circuitry configured to generate an angular-resolved and spectrally resolved scattering matrix based on the one or more dark-field micrographs of the object. | 05-01-2014 |
20140118526 | Curvilinear sensor system - Methods and apparatus for a Curvilinear Sensor System are disclosed. The present invention includes a wide variety of generally curved, aspheric or non-planar arrangement of sensors and their equivalents. The curvilinear surfaces, edges or boundaries that define the geometry of the present invention may be continuous, or may be collections or aggregations of many small linear, planar or other segments which are able to approximate a curved line or surface. | 05-01-2014 |
20140118527 | MATCHING OBJECT GEOMETRY WITH ARRAY MICROSCOPE GEOMETRY - A method for object preparation for imaging with an array microscope system without scanning. Artifact-free image is formed based on scanning-free imaging of an object array formed from spatially-separated portions of the initially spatially-continuous object that are arranged, in the object plane of the array microscope, in a pattern associated with an array of individual objectives of the array microscope. The size of an individual portion of the object does not exceed the size of a FOV of the individual objective defined in the object plane. | 05-01-2014 |
20140118528 | SETTING UNIT AND METHOD FOR SETTING A SEQUENCE FOR THE AUTOMATIC RECORDING OF IMAGES OF AN OBJECT BY MEANS OF A RECORDING DEVICE, AND RECORDING DEVICE HAVING SUCH A SETTING UNIT - A setting unit for sequencing automatic recording of images with a recording device. The setting unit provides a first input interface via which a recording program can be set, provides a second input interface via which at least one parameter, which is to be monitored during the execution of the sequence, is proposed and can be selected in dependence on the recording program, provides a third input interface via which at least one condition, and at least one action upon fulfilment of the condition, can be set for the parameter, and generates control data for the control module. | 05-01-2014 |
20140125790 | Device And Method For Three Dimensional Imaging Of Biological Sample - A device and method are provided for generating a three dimensional image of a volume of biological material. A plurality of layers of biological material are sequentially removed therefrom. Images of each layer of the biological sample are captured prior to removal. Each image includes information from a layer and from a portion of the biological material below the layer. The information from the layer is isolated from the portion of material below the layer for each image. The three dimensional image is generated from the isolated information of each layer. | 05-08-2014 |
20140146157 | SYSTEM AND METHOD FOR SAMPLE DILUTION AND PARTICLE IMAGING - A system for diluting a sample fluid sufficiently to enable the capture images of particles contained in the sample fluid. The system includes a fluid dilution system and a particle imaging system. The fluid dilution system includes a mixing conduit for combining a diluent and the sample solution. The mixing conduit is coupled to a flow chamber associated with imaging capturing devices including a camera. When the sample fluid is too opaque or viscous to enable capture of particle images of sufficient clarity, the fluid dilution system is activated to introduce diluent into the mixing conduit in sufficient volume to dilute the sample fluid. The diluted sample fluid is passed through the flow chamber and particle images captured. Information regarding captured images may be stored, analyzed and transferred from a remote location. | 05-29-2014 |
20140146158 | DEVICE FOR MICROSCOPIC EXAMINATION - A device for microscopic examination includes an image output unit, at least two image input units, which are arranged in a spatially distributed manner and which have different sample receiving regions, at least one object carrier unit which supports at least one sample, in particular at least one biological sample, and includes a coupling unit, which couples the image output unit and one of the at least two image input units optically to form a microscope unit. | 05-29-2014 |
20140146159 | Z-MICROSCOPY - We present a method for parallel axial imaging, or z-microscopy, utilizing an array of tilted micro mirrors arranged along the axial direction. Image signals emitted from different axial positions can be orthogonally reflected by the corresponding micro mirrors and spatially separated for parallel detection, essentially converting the more challenging axial imaging to a lateral imaging problem. Each micro mirror also provides optical sectioning capability due to its finite dimension. | 05-29-2014 |
20140152793 | TECHNIQUES FOR SCANNED ILLUMINATION - Imaging systems are provided for high speed, high resolution imaging of biochemical materials. In an example embodiment, an imaging system comprises an objective lens component, a line generator, a digital camera, a positioning stage, and a scan mirror. The line generator generates a line of light that is scanned across a portion of a substrate that is mounted on the positioning stage. The positioning stage moves the substrate in a particular direction that is substantially normal to an optical axis of the objective lens component. The camera collects an image of the portion of the substrate through the objective lens component. The scan mirror moves in coordination with the positioning stage, while the line of light is being scanned across the portion of the substrate and the substrate is being moved in the particular direction, in order to keep the image still with respect to the camera while the image is being collected by the camera. | 06-05-2014 |
20140152794 | Measurement Microscope Device, Image Generating Method, Measurement Microscope Device Operation Program, And Computer-Readable Recording Medium - An image with a wide visual field can be captured without causing deterioration in measurement accuracy. There are provided: a stage on which an object is placed; a display unit for displaying a height image or an observation image; a measurement unit for performing measurement on the height image; an image connecting unit configured to, by moving the stage and capturing a different region, acquire a plurality of height images, and connect the obtained plurality of height images and observation images to generate a connected image; a measurement error region display unit configured to superimpose and display a measurement error region, on an image of the object; and a measurement-image imaging condition setting unit for adjusting an imaging condition for a striped image required for generation of the height image to reduce the measurement error region. | 06-05-2014 |
20140152795 | OPTICAL APPARATUS - An optical apparatus includes: laser; objective that irradiates a sample with laser light; phase-modulation spatial light modulator that is located at a pupil conjugate position of the objective and modulates a phase of the laser light; scan unit that scans the sample with the laser light; detector that detects observation light from the sample; image generating unit that generates a sample image according to a signal from the detector and control information of the scan unit; and controlling unit that sets for the modulator a modulation amount of the phase of laser light in accordance with a pattern to be formed on the sample using the laser light. According to the pattern to be formed on the sample and a pattern of irradiation with the laser light obtained from the image generated by the image generating unit, the controlling unit corrects the modulation amount that is set for the modulator. | 06-05-2014 |
20140152796 | AUTO FOCUS CONTROL APPARATUS, SEMICONDUCTOR INSPECTING APPARATUS AND MICROSCOPE - An auto focus control apparatus is provided to perform an auto focus adjustment using astigmatism without being affected by a pattern on a surface. A light receiving optical system includes an unpolarized beam splitter | 06-05-2014 |
20140152797 | CONFOCAL OPTICAL INSPECTION APPARATUS AND CONFOCAL OPTICAL INSPECTION METHOD - The confocal optical inspection apparatus that acquires a confocal image of an object and inspects the object includes a light source that emits illumination light; a first opening member that divides the illumination light emitted from the light source into illumination light beams, the first opening member having openings; an imaging device that acquires an image according to the respective illumination light beams reflected by the object; and an information processor that acquires a corrected confocal image in which distortion of an optical transmission path of the confocal optical inspection apparatus is removed from a time delayed integration (TDI) image obtained by a TDI operation of the imaging device, using a pre-measured point spread function (PSF) indicating optical characteristics of the confocal optical inspection apparatus. | 06-05-2014 |
20140152798 | LIGHT MEASUREMENT DEVICE, LIGHT MEASUREMENT METHOD, AND LIGHT MEASUREMENT PROGRAM - A light measurement device is a light measurement device for measuring light coming from a sample, and is provided with a moving-image acquisition part for acquiring moving image data, and an analysis processing part for performing analysis processing on moving image data. The analysis processing part includes: a luminance-value-data acquisition part for acquiring luminance value data indicating a chronological change in a luminance value; a luminance-value extraction part for extracting a peak value and a bottom value of the luminance value, from the luminance value data; and a pixel specifying part for calculating an evaluation value evaluating a state of a change in a luminance value on the basis of the peak value and the bottom value and specifying a target pixel that is to be analyzed from a plurality of pixels on the basis of a repeat state of the evaluation value. | 06-05-2014 |
20140152799 | LIGHT MEASUREMENT DEVICE, LIGHT MEASUREMENT METHOD, AND LIGHT MEASUREMENT PROGRAM - The light measurement device is provided with a moving-image acquisition part and an analysis processing part. The analysis processing part includes: a luminance-value-data acquisition part for acquiring the luminance value data; a luminance-value extraction part for extracting a peak value and a bottom value of the luminance value, from the luminance value data; a pixel extraction part for extracting a target pixel configuring an image of a predetermined cell from a plurality of pixels, on the basis of the evaluation value. The pixel extraction part extracts, as the evaluation value, the target pixel on the basis of at least one of an amplitude of the luminance value obtained from a difference between the peak value and the bottom value and a change ratio of the luminance value obtained from a ratio of the peak value relative to the bottom value. | 06-05-2014 |
20140152800 | IMAGE QUALITY OPTIMIZATION OF BIOLOGICAL IMAGING - Microscopy system for biological imaging, comprising an image quality optimizer for optimizing image quality of an image of a biological sample, allowing a user to select an optimization mode from a list of functionally defined optimization modes, and wherein the system is arranged to automatically set one or more image acquisition parameters to achieve optimal imaging for the selected optimization mode based on at least one image quality parameter derived from one or more Biological Reference Objects (BRO) in the image of the biological sample selected by the user or automatically by the system. | 06-05-2014 |
20140152801 | Detecting and Using Light Representative of a Sample - An imaging device includes light sensitive locations that are separately sensitive to light received at a surface with respect to a portion of a sample associated with the surface, the light sensitive locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light sensitive locations are such that usable useful image of the portion of the sample can be acquired directly by operation of the imaging device. | 06-05-2014 |
20140160264 | AUGMENTED FIELD OF VIEW IMAGING SYSTEM - An augmented field of view imaging system includes a microscope, an image sensor system arranged to receive images of a plurality of fields of view from the microscope as the microscope is moved across an object being viewed and to provide corresponding image signals, an image processing and data storage system configured to communicate with the image sensor system to receive the image signals and to provide augmented image signals, and at least one of an image injection system or an image display system configured to communicate with the image processing and data storage system to receive the augmented image signals and display an augmented field of view image. The image processing and data storage system is configured to track the plurality of fields of view in real time and register the plurality of fields of view to calculate a mosaic image. The augmented image signals from the image processing and data storage system provide the augmented image such that a live field of view from the microscope is composited with the mosaic image. | 06-12-2014 |
20140160265 | Switchable microscope arrangement with multiple detectors - The invention relates to a microscope arrangement provided with: a microscope ( | 06-12-2014 |
20140160266 | SINGLE IMAGE SUPER-RESOLUTION MICROSCOPY AND TELESCOPE SYSTEMS - Image resolution enhancement techniques are implemented using a single image an unstructured broadband illumination. By placing an axicon and a convex lens pair in an optical path of a microscope, telescope, or the object system, between the system and an image capture pickup device (e.g., a camera) the maximum resolution of the system may be increased through the formation of an interference pattern at the image capture device. | 06-12-2014 |
20140160267 | Image Pickup Apparatus - An image pickup apparatus includes a measuring section configured to measure a surface shape of an object, an image pickup section configured to obtain images of different areas of the object on an image plane of an image pickup optical system by image pickup elements, a focal-position detecting unit configured to detect a focal position of the object where a focal-position detecting point is focused on the image plane, and a focal-position determining unit configured to determine a focal position of the object at a point different from the focal-position detecting point on the basis of detection of the focal-position detecting unit and measurement of the measuring section. The image pickup section takes the images of the different areas on the basis of determination of the focal-position determining unit while the images are focused on the image pickup elements. | 06-12-2014 |
20140168402 | Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus - Continuous-scanning image acquisition in an automated microscopy system uses an image reflected off of an object that supports a specimen being imaged to automatically focus the microscopy system. | 06-19-2014 |
20140168403 | DIGITAL MICROSCOPE SYSTEM - A digital microscope system, having one or several objectives, a tube lens system, a digital image recording device, a stand, a holder for a specimen and an illuminating apparatus, and optionally at least one magnification changer. One or several objectives, the tube lens system, the digital image recording device and the illuminating apparatus are integrated into a compact optical assembly, and the optical assembly is joinable to the stand in several versions that differ with regard to the spatial position and orientation of the optical assembly relative to the stand and to the specimen. The spatial position and orientation of the optical assembly relative to the stand and to the specimen may correspond, in a first version of the joining, to an upright microscope configuration and, in a second version of the joining, to an inverted microscope configuration. | 06-19-2014 |
20140168404 | AUTOFOCUS METHOD FOR MICROSCOPE AND MICROSCOPE WITH AUTOFOCUS DEVICE - An autofocus method for a microscope with an objective which images a sample lying in an object plane, including the steps: projecting a longitudinally extended grating slit which lies in a grating slit plane onto the sample, and imaging the projection of the grating slit onto an autofocus camera; determining an intensity distribution of the grating slit image and from this, deducing a preset for a relative adjustment of sample and object plane; projecting a likewise longitudinally extended comparison slit onto the sample, and imaging the projection of the comparison slit onto the autofocus camera; evaluating the width of the comparison slit image at right angles to the longitudinal extension at at least two sites which are spaced apart along the longitudinal extension, and determining a width variation of the comparison slit image, a gradient of the width variation and a direction of the relative adjustment. | 06-19-2014 |
20140176694 | Imaging system - The invention provides an novel imaging system for microscopy including both continuous motion and stationary field image acquisition. More specifically, the invention provides a system that can translate a specimen relative to the field-of-view of an imager while synchronously acquiring image data. Using the same imaging optics and imager, the system can acquire stationary images at any location on the specimen. | 06-26-2014 |
20140184776 | MICRO OR NANO SCOPE - Provided is a micro or nano scope. The micro or nano scope includes a prism, a optical detection system detecting an image from a sample on the prism, and a light guiding system providing incident light to the prism, the light guiding system changing an incident angle of the incident light incident into the prism. | 07-03-2014 |
20140184777 | HIGH-RESOLUTION LUMINESCENCE MICROSCOPY - A microscopy method for generating a high-resolution image ( | 07-03-2014 |
20140184778 | IMAGE PROCESSING APPARATUS, CONTROL METHOD FOR THE SAME, IMAGE PROCESSING SYSTEM, AND PROGRAM - An image processing apparatus is configured to generate a display image used to display a captured image captured by imaging a slide on which a specimen is placed. The image processing apparatus includes an acquisition unit configured to acquire an overall image generated from the captured image for displaying the entirety of the slide and a magnified image generated from the captured image for displaying a portion of the specimen in a magnified manner and a generation unit configured to generate a display image containing the overall image and the magnified image. The magnified image is a rotated image rotated relative to the overall image on the basis of specimen information about a feature of the specimen displayed in a magnified manner. | 07-03-2014 |
20140192178 | METHOD AND SYSTEM FOR TRACKING MOTION OF MICROSCOPIC OBJECTS WITHIN A THREE-DIMENSIONAL VOLUME - Phase contrast microscopy images are collected of a liquid sample containing one or more microscopic objects. The images are analyzed to track the motion of the microscopic objects within the liquid sample. Using the updated locations of the tracking objects, a controller can generate control signals for controlling the microscopy parameters, to ensure that the portion of the liquid sample which is imaged includes the tracking objects. The tracking objects may be cells or cell-spheres. Thus, the system can, for example, track cells and cell-spheres, to observe their growth, during a long time-lapse experiment. | 07-10-2014 |
20140198197 | IMAGE PROCESSING APPARATUS, MICROSCOPE SYSTEM, AND RECORDING MEDIUM - An image processing apparatus includes: a normalization unit that generates a plurality of normalized images by correcting, based on different imaging conditions, brightness of a plurality of images at different brightness obtained by imaging a same subject with the different imaging conditions; and an image combining unit that generates a combined image by combining the plurality of normalized images. When the normalized image corresponding to a reference image that is a brightest image among the plurality of images is defined as a reference normalized image, the image combining unit combines the reference normalized image and a non-reference normalized image that is the normalized image other than the reference normalized image to bring gradation of pixel of the combined image close to gradation of pixel of the reference normalized image if the gradation of pixel of the combined image is smaller than the gradation of pixel of the reference normalized image. | 07-17-2014 |
20140198198 | CUMULANT MICROSCOPY - The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction of super-resolved environment-related parameter maps, such as molecular state lifetimes, concentration and brightness distributions of the emitter. In addition, such parameter maps can be used to compensate for the non-linear brightness and blinking response of higher-order cumulant images—used for example in Super-resolution Optical Fluctuation Imaging (SOFI)—to generate a balanced image contrast. Structures that otherwise would be masked by brighter regions in the conventional cumulant image become samples using spectral cross-cumulants. | 07-17-2014 |
20140198199 | IMAGE ACQUISITION APPARATUS, IMAGE ACQUISITION METHOD, AND INFORMATION PROCESSING PROGRAM - An image acquisition apparatus includes: a macro-photographing unit that performs macro-photographing of an image of at least a sample mounting area of a slide, on which a pathological sample is mounted, at a first magnification; a microscopic photographing unit that microscopically photographs a designated photographing area at a second magnification larger than the first magnification; a first judgment unit that judges whether there is an image of the pathological sample in each of a plurality of sectional areas sectioning the image obtained by the macro-photographing; a second judgment unit that judges, as a sample image area, a set of at least one of the plurality of sectional areas judged to be including the image of the pathological sample; and an area expansion unit that generates an expanded area by expanding the sample image area and causes the microscopic photographing unit to photograph the expanded area as the photographing area. | 07-17-2014 |
20140198200 | BESSEL BEAM PLANE ILLUMINATION MICROSCOPE - A microscope has a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a Bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beam and for imaging the received light on a detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction. A detector is configured for detecting signal light received by the imaging optics, and an aperture mask is positioned | 07-17-2014 |
20140198201 | BESSEL BEAM PLANE ILLUMINATION MICROSCOPE - A microscope has a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a Bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beam and for imaging the received light on a detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction. A detector is configured for detecting signal light received by the imaging optics, and an aperture mask is positioned | 07-17-2014 |
20140204194 | DEFECT OBSERVATION METHOD AND DEVICE THEREFOR - This invention relates to a method for performing an analysis of defective material and the refractive index, and a three-dimensional analysis of very small pattern shapes including the steps of imaging by a scanning electron microscope to acquire an image of the position of a defect under observation using information of inspection results obtained by an optical inspection device, creating a model of the defect by using the acquired image of the defect under observation, calculating the values detected by the detector when reflected and scattered light emitted from a defect model is received by the detector when light is irradiated onto the defect model thus created, comparing the detection values thus calculated and the values detected by the detector, which has received light actually reflected and scattered from the sample, to obtain information relating to the height of the defect under observation, the material, or the refractive index. | 07-24-2014 |
20140204195 | MICROSCOPE, OBJECTIVE OPTICAL SYSTEM, AND IMAGE ACQUISITION APPARATUS - A microscope includes an objective optical system including an imaging optical system configured to form an image of an object, a re-imaging optical system configured to re-form an image of the object image formed by the imaging optical system, and a reflection unit arranged on an optical path between the imaging optical system and the re-imaging optical system and configured to be locally changeable in at least one of a position thereof in an optical axis direction and an inclination thereof relative to an optical axis, and an image sensor configured to capture the image re-formed by the objective optical system. | 07-24-2014 |
20140210980 | IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION METHOD - An image acquisition apparatus includes a photographing unit, an AF (Auto Focus) processing unit, and a calculation unit. The photographing unit is configured to photograph a pathological sample mounted on a slide glass using an objective lens. The AF processing unit is capable of selectively making a switch between a contrast AF method and a phase difference AF method for focusing a focal point of the objective lens on the pathological sample. The calculation unit is configured to judge a staining method of the pathological sample and select the AF method to be executed by the AF processing unit based on a result of the judgment. | 07-31-2014 |
20140210981 | METHOD FOR PRESENTING AND EVALUATION OF IMAGES OF MICRO-TITER PLATE PROPERTIES - A system and method is provided for determining selected properties of a microplate comprising a plurality of sample wells. An example method includes the steps of performing a focusing function to determine a well surface z-position for a current x-y position based on an intensity indicative of a best focus of the well surface. The focusing function is performed again to determine a plate bottom z-position for the current x-y position based on an intensity indicative of a best focus of the plate bottom. The well surface z-position and the plate bottom z-position corresponding to each of the plurality of x-y positions are determined by repeating the steps of positioning the objective lens, performing the focusing function to determine the well surface z-position, and performing the focusing function for the plate bottom z-position. The well surface z-positions and the plate bottom z-positions at the plurality of x-y positions are then used to generate data to determine the selected properties of the microplate. | 07-31-2014 |
20140218499 | IMAGE OBTAINING APPARATUS AND STAGE CONTROL METHOD - An image obtaining apparatus includes an image pickup unit, a stage, a connection unit, a movement mechanism, a position detection unit, and a control unit. The image pickup unit includes an objective lens. The stage is configured to determine a position of a pathology slide in an optical axis direction of the objective lens, and the pathology slide is an image pickup target of the image pickup unit. The connection unit is provided to the stage. The movement mechanism is connected to the stage through the connection unit and configured to move the stage in the optical axis direction. The position detection unit is configured to detect a position of the stage in the optical axis direction for a measurement point preset on the stage. The control unit is configured to control the movement mechanism by using at least a result of the detection by the position detection unit. | 08-07-2014 |
20140232844 | METHOD AND APPARATUS FOR DEFINING A Z-RANGE IN A SAMPLE, IN WHICH A Z-STACK OF THE SAMPLE IS TO BE RECORDED BY MEANS OF A MICROSCOPE - A method for defining a z-range in a sample in which a z-stack of the sample is to be recorded by means of a microscope is provided, wherein the z-range is defined automatically on the basis of a z-value situated in the sample and taking at least one predetermined parameter into account. | 08-21-2014 |
20140232845 | METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT - A method and associated system for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays. | 08-21-2014 |
20140232846 | IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION SYSTEM - An image acquisition apparatus includes an imaging optical system configured to form an image of an object, a re-imaging optical system configured to re-form the image of the object formed by the imaging optical system, a reflecting member arranged on an optical path between the imaging optical system and the re-imaging optical system, an image sensor configured to capture the image of the object re-formed by the re-imaging optical system to output image data, a first driving unit configured to change a tilt of the reflecting member with respect to an optical axis of the imaging optical system, a control unit configured to control the first driving unit according to a shape of the object, and a correction unit configured to correct a positional displacement of the image in an in-plane direction according to the change in the tilt of the reflecting member. | 08-21-2014 |
20140247337 | MICROSCOPE APPARATUS - Unnecessary degradation of a light detector is prevented. Provided is a microscope apparatus ( | 09-04-2014 |
20140267669 | FLOW CELL ALIGNMENT METHODS AND SYSTEMS - Imagers and alignment methods for use by imagers imaging deoxyribonucleic acid (DNA) fragments on a flow cell are disclosed. The imagers capture intensity values at DNA fragment bead locations in tiles with each tile having a reference location in the flow cell. Flow cells may be aligned by obtaining a dark field image of each tile during a first imaging session, identifying dark field constellations of bead locations within two separate tiles during the first imaging session, identifying corresponding constellations during a second imaging session, altering the reference location of at least one tile during the second imaging session to correct for a linear offset in the corresponding constellations, and applying at least one correction factor for reading out intensity values from the imager for the bead locations in the flow cell to correct for an angular offset determined from offsets in the corresponding constellations. | 09-18-2014 |
20140267670 | MOBILE MICROSCOPY DEVICE AND METHOD THEREFOR - A mobile microscopy apparatus usable in connection with a mobile computing device comprising a memory unit and camera, the mobile microscopy apparatus comprising: an illumination module for illuminating a removable media with an illuminating light, an image acquisition optics for creating an image of the sample for acquisition by the camera of the mobile computing device, and a mounting frame assembly for detachably mounting the illumination module and the image acquisition optics to the mobile computing device and for holding the removable media in a predetermined position. In various implementations, the illumination module may provide either backside or frontside illumination of the removable media using the light generated by a light source of the mobile computing device. The mobile microscopy apparatus may operate in the microscope configuration, visible colormatic microarray configuration, and/or fluorescent microarray configuration. | 09-18-2014 |
20140267671 | REFERENCING IN MULTI-ACQUISITION SLIDE IMAGING - Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform. | 09-18-2014 |
20140267672 | DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY - Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest. | 09-18-2014 |
20140267673 | DIGITAL MICROSCOPE APPARATUS, METHOD OF SEARCHING FOR IN-FOCUS POSITION THEREOF, AND PROGRAM - A digital microscope apparatus includes a first imaging unit including a first imaging device and a first optical system including an objective lens configured to enlarge first and second images of a preparation that holds a sample, the first image being formed on the first device through the first system, a second imaging unit including a second optical system that is branched from the first system and has a depth of field larger than the first system and a second imaging device on which the second image is formed through the second system, and a controller configured to calculate a provisional in-focus position of the lens based on the second image, determine an area of the first device, from which the first image is read, and search for, based on the read image, an in-focus position of the lens in a predetermined range based on the provisional in-focus position. | 09-18-2014 |
20140267674 | PARTITIONED APERTURE WAVEFRONT IMAGING METHOD AND SYSTEM - A partitioned aperture wavefront imaging system includes an imaging system comprising a partitioned aperture lens array positioned at the aperture plane or Fourier plane between the entrance plane and camera plane of an imaging system. The partitioned aperture lens array can include 2 or more off-axis lenses symmetrically distributed about an optical axis, and adapted to produce simultaneously at the camera plane at least two images of an object, or intermediate image of an object, presented at the entrance plane. Preferably, the partitioned aperture lens array includes from 3 to 5 off-axis lenses and produces 3 to 5 images at the camera plane from which phase and amplitude information about the light field can be determined. The partitioned aperture wavefront imaging system provides enough information about the light field presented at the entrance plane to enable reconstruction of the light field at other planes relative to the entrance plane. | 09-18-2014 |
20140285650 | PHASE DISTRIBUTION MEASUREMENT METHOD AND PHASE DISTRIBUTION MEASUREMENT APPARATUS - A phase distribution measurement method inside a biological sample includes taking in an optical image of the sample formed by a microscope to form a plurality of images with different image contrasts; calculating a component corresponding to phase distribution of the sample and a component corresponding to other than the phase distribution, and dividing the component corresponding to the phase distribution by the component corresponding to other than the phase distribution to forma normalized phase component image; breaking down the phase component image into a plurality of frequency components; performing a deconvolution process to each of the frequency components using an optical response character corresponding to each, and calculating phase distribution of a refraction component and phase distribution of a structure component; and calculating phase distribution of the sample by compounding the phase distribution of the refraction component and the phase distribution of the structure component. | 09-25-2014 |
20140285651 | BESSEL BEAM PLANE ILLUMINATION MICROSCOPE - A microscope has a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a Bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beam and for imaging the received light on a detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction. A detector is configured for detecting signal light received by the imaging optics, and an aperture mask is positioned | 09-25-2014 |
20140293034 | IMAGING DEVICE - Provided is a technique that makes it possible to inexpensively image a miniscule target located inside or on the surface of a light-transmitting substrate. An imaging device ( | 10-02-2014 |
20140293035 | IMAGE PROCESSING APPARATUS, IMAGING APPARATUS, MICROSCOPE SYSTEM, IMAGE PROCESSING METHOD, AND COMPUTER-READABLE RECORDING MEDIUM - An image processing apparatus includes: an image inputting unit configured to input a plurality of images having a portion where at least a part of subjects of the plurality of images is common to one another; and a correction image generating unit configured to generate a correction image used for correcting the plurality of images. The correction image generating unit includes: a difference acquiring unit configured to acquire a difference between luminance of pixels from two arbitrary images of the plurality of images, the two arbitrary images having a common portion where the subjects are common to one another; and a shading detection unit configured to detect a shading component in the arbitrary images based on the difference. | 10-02-2014 |
20140300723 | ANALYSIS APPARATUS, ANALYSIS PROGRAM, AND ANALYSIS SYSTEM - An analysis apparatus includes a two-dimensional coordinate detecting unit and a three-dimensional coordinate determining unit. The two-dimensional coordinate detecting unit is configured to detect, with respect to a captured image group obtained by capturing an analysis specimen including an analysis target object at a plurality of focal depths, a two-dimensional coordinate candidate being a candidate of a plane coordinate of the analysis target object in each captured image. The three-dimensional coordinate determining unit is configured to determine, based on a position relationship of the plane coordinate candidates between the captured images, a three-dimensional coordinate candidate being a candidate of a three-dimensional coordinate of the analysis target object. | 10-09-2014 |
20140300724 | OPTIMIZING VIRTUAL SLIDE IMAGE QUALITY - Systems, methods, and media for assessing the quality of a microscope slide image. In an embodiment, a plurality of focus point values are acquired for a sample on a microscope slide. Each focus point value comprises x-y coordinates indicating a location on the sample and a z coordinate indicating a focus height for the location on the sample. A best-fit surface is calculated based on the focus point values, and it is determined whether or not outlying focus point values exist based on the best-fit surface and the z coordinate for one or more of the focus point values. A scanned image of the microscope slide may be displayed which comprises, for each outlying focus point value, an overlay that identifies the location on the sample of the outlying focus point value based on the x-y coordinates for the outlying focus point value. | 10-09-2014 |
20140307079 | Cell Contour Formation Apparatus and Method of the Same, and Non-Transitory Contour Readable Storage Medium Storing a Cell Contour Formation Program - An cell contour formation apparatus includes a cell image acquiring unit, a subband image creating unit, a features calculating unit, a correcting unit, a contour forming unit. The subband image creating unit creates subband images including a low frequency image and a high frequency image. The features calculating unit calculates a local texture features from the high frequency image. The correcting unit corrects the high frequency image on the basis of the pixel value of the low frequency image and the texture features. The contour forming unit forms contours of cells included in the cell group on the basis of the corrected high frequency image. | 10-16-2014 |
20140313310 | METHODS FOR OPTICAL AMPLIFIED IMAGING USING A TWO-DIMENSIONAL SPECTRAL BRUSH - An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode spatial information from a sample into a back reflection of a two-dimensional spectral brush that is generated with a two-dimensional disperser and a light source that is mapped in to the time domain with a temporal disperser. The temporal waveform is preferably captured by an optical detector, converted to an electrical signal that is digitized and processed to provide two dimensional and three dimensional images. The produced signals can be optically or electronically amplified. Detection may be improved with correlation matching against a database in the time domain or the spatial domain. Embodiments for endoscopy, microscopy and simultaneous imaging and laser ablation with a single fiber are illustrated. | 10-23-2014 |
20140313311 | CONTROL DEVICE AND METHOD FOR CONTROLLING A MOTORIZED DIGITAL MICROSCOPE - The invention relates to a control device and to a method for controlling a motorized digital microscope. The control device comprises at least one first module ( | 10-23-2014 |
20140313312 | DIGITAL MICROSCOPE AND METHOD FOR OPTIMIZING THE WORK PROCESS IN A DIGITAL MICROSCOPE - The invention relates to a digital microscope and to a method for optimizing a work process in such a digital microscope. The digital microscope comprises according to the invention at least one first monitoring sensor for observing a sample ( | 10-23-2014 |
20140313313 | FULLY AUTOMATIC RAPID MICROSCOPE SLIDE SCANNER - Microscope slide scanner. In an embodiment the microscope slide scanner comprises a single enclosure unit that includes at least one objective lens, at least one line scan camera, at least one communication port, and at least one processor. The line scan camera may be configured to capture image data of a sample as a plurality of image stripes via the objective lens. The communication port provides communication over a network. The processor may align the plurality of image stripes into a contiguous image of at least a portion of the sample, and executes a web server that provides an operator interface over the network to one or more remote devices. | 10-23-2014 |
20140313314 | Data Management in a Linear-Array-Based Microscope Slide Scanner - Systems and methods for capturing image data using a line scan camera. In an embodiment, a line scan camera captures image data of a sample as a plurality of image stripes. A processor may coarsely align two or more of the plurality of image stripes according to a synchronization process while the line scan camera is capturing at least one of the plurality of image stripes. Subsequently, the processor may also finely align the two or more image stripes using pattern matching. | 10-23-2014 |
20140320625 | LOUPE ACCESSORY AND VIEWING METHOD - A loupe accessory comprising: a loupe, comprising a first lens characterized in a positive focal length of less than 350 mm, the first lens for producing substantially infinity rays from a relatively close object, and an infinity-focus camera, comprising an image sensor and a second lens disposed at a fixed distance from the image sensor, the fixed distance being a focal length of the second lens, wherein the infinity-focus camera is fixed to the first lens, for imaging the infinity rays on the image sensor, thereby a first portion of the infinity rays produced by the first lens is imaged by the infinity-focus camera, and a second portion of the infinity rays produced by a second portion of the first lens is directly viewed by a human eye. | 10-30-2014 |
20140320626 | MICROSCOPE FOR MONITORING OPTICAL COHERENCE TOMOGRAPHY - A microscope for monitoring optical coherence tomography includes a microscope image providing unit which is configured to include a first objective lens, a beam splitter, and an ocular lens which are sequentially disposed from the front of a sample mount and an optical coherent tomography (OCT) image providing unit which generates an OCT image and provides the OCT image to the beam splitter of the microscope image providing unit, wherein the OCT image providing unit generates the OCT image of the same position as the surface image of the sample and provides the OCT image to the beam splitter of the microscope image providing unit, and in the case where the OCT image is provided through the beam splitter to the OCT image providing unit, the microscope image providing unit simultaneously outputs the surface image and the OCT image of the sample to the ocular lens. | 10-30-2014 |
20140327756 | USER-FRIENDLY WIRELESS FIBER OPTIC ENDFACE INSPECTOR - A wireless fiber optic endface inspector includes a video microscope capable of wirelessly transmitting video streaming signal of endface image in real-time to a display device. The video microscope includes a microscope optical system, an adapting tip for interfacing an endface, an LED light source, a camera module for receiving and converting the endface image into video streaming signal, a Wi-Fi AP board, and a battery for supplying power. The video microscope may be constructed by adding a Wi-Fi AP board and a battery to a conventional inspector microscope. The display device has software for detecting when the endface is focused. Once the endface is focused, the display device emits an audio signal to alert the operator, who may then trigger the display device to analyze the endface image using an endface analysis software or save it to a folder, or transmit the image to a remote server. | 11-06-2014 |
20140327757 | ADJUSTABLE DIGITAL MICROSCOPE DISPLAY - The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. | 11-06-2014 |
20140327758 | ADJUSTABLE DIGITAL MICROSCOPE DISPLAY - The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus. | 11-06-2014 |
20140333750 | HIGH RESOLUTION DUAL-OBJECTIVE MICROSCOPY - The present invention generally relates to super-resolution microscopy. For example, certain aspects of the invention are generally directed to a microscopy system comprising at least two objectives. In some embodiments, the microscopy system may also contain a non-circularly-symmetric lens. One or more images can be obtained using the objectives, for example, using stochastic imaging techniques such as STORM (stochastic optical reconstruction microscopy), optionally in conjunction with entities that are photoactivatable and/or photo switchable. The images obtained using the objectives may be compared, e.g., to remove noise, and/or to compare an entity present in both images, for instance, to determine the z-position of the entity. In some cases, surprisingly high resolutions may be obtained using such techniques, for example, resolutions of better than about 10 nm. | 11-13-2014 |
20140333751 | IMAGE PROCESSING APPARATUS AND SYSTEM, METHOD FOR PROCESSING IMAGE, AND PROGRAM - An image processing apparatus includes an image data acquisition unit, a display control unit, an area-information acquisition unit, and a detection unit. The image data acquisition unit acquires Z-stack image data including multiple layer images obtained by using a microscope apparatus. The display control unit displays at least one of the layer images on a display apparatus as an observation image. The area-information acquisition unit acquires information about a target area in the observation image specified by a user. The detection unit detects in-focus information for a corresponding area for the target area in each of the layer images. The display control unit displays an image indicating a positional relationship between the target area and the corresponding area which is closer to an in-focus state than the target area, along with the target area on the display apparatus, based on the result from the detection unit. | 11-13-2014 |
20140340499 | SYSTEMS AND METHODS FOR SAMPLE IMAGE CAPTURE USING INTEGRATED CONTROL - Embodiments relate to systems and methods for sample image capture using integrated control. A digital microscope or other imaging device can be associated with a sample chamber containing cell, tissue, or other sample material. The chamber can be configured to operate using a variety of environmental variables, including gas concentration, temperature, humidity, and others. The imaging device can be configured to operate using a variety of imaging variables, including magnification, focal length, illumination, and others. A central system control module can be used to configure the settings of those hardware elements, as well as others, to set up and carry out an image capture event. The system control module can be operated to control the physical, optical, chemical, and/or other parameters of the overall imaging environment from one central control point. The variables used to produce the image capture can be configured to dynamically variable during the media capture event. | 11-20-2014 |
20140340500 | Surgical Microscope with Enlarged Working Distance - A surgical microscope | 11-20-2014 |
20140340501 | SURGICAL MICROSCOPE WITH POSITIONING AID - A microscope comprises an imaging system comprising an objective having an objective lens and producing a magnified image of a focal plane of the imaging system, an image sensor disposed in the focal plane and outputting an electrical signal to the controller, and a display communicating with the controller. The controller converts signals of the image sensor into digital single images of the object, outputs the same to the display, detects a displacement of the microscope transverse to an optical axis of the objective lens relative to an object imaged, and compares the displacement with a threshold. If the displacement exceeds the threshold the controller controls a zoom system such that a total magnification is inverse monotone to a relative velocity between the microscope and the object, and/or stores the digital single images, composes them into a total image, and outputs the same to the display. | 11-20-2014 |
20140340502 | METHODS AND APPARATUS FOR REFRACTIVE FLOW MEASUREMENT WITH THREE DIMENSIONS AND UNCERTAINTY - An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video captured by a video camera with an imaging plane. Representations of motions in the video are correlated. A textured background of the scene can be modeled as stationary, with a refractive field translating between background and video camera. This approach offers multiple advantages over conventional fluid flow visualization, including an ability to use ordinary video equipment outside a laboratory without particle injection. Even natural backgrounds can be used, and fluid motion can be distinguished from refraction changes. Depth and three-dimensional information can be recovered using stereo video, and uncertainty methods can enhance measurement robustness where backgrounds are less textured. Example applications can include avionics and hydrocarbon leak detection. | 11-20-2014 |
20140340503 | OBSERVATION DEVICE - An observation device is provided with a light source section, a detection section and an arithmetic operation section. The light source section emits light to a moving object from multiple directions. a detection section is disposed on a predetermined plane such that scattered light having an identical scattering angle enters at an identical position, outputs data temporally changing at a frequency corresponding to an amount of Doppler shift of light that reaches at each position on the predetermined plane. An arithmetic operation section performs a one-dimensional Fourier transform with respect to time variables, for data having a position in the first direction on the predetermined plane, a position in the second direction on the predetermined plane, and a time as variables, and extracts data having an identical incident angle relative to the object from the Fourier-transformed data, on the basis of Doppler Effect. | 11-20-2014 |
20140347459 | Method and System for Imaging a Cell Sample - The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level. | 11-27-2014 |
20140347460 | COINCIDENT FOCUS MICROSCOPE HAVING SUPERIOR RESOLUTION AND CONTRAST IN THREE DIMENSIONS - A microscope having an objective lens and illumination means configured in combination such that said illumination means illuminates a specimen through a different region of the objective lens than that used for observation, and having an opaque region separating the illumination and observation regions. The basic optical design is capable of resolving optically isolated micron-sized voxels deep within tissue, without the use of a computer and when illuminated only with visible light. | 11-27-2014 |
20140347461 | MICROSCOPE FOR WIDEFIELD MICROSCOPY - A microscope for microscopy having a detection beam path and an illumination beam path. The microscope includes a filter wheel device, which is arranged in the detection beam path and/or illumination beam path and has a filter wheel, wherein the filter wheel is mounted to rotate about an axis, and wherein the filter wheel is divided into segments. Filters forming a first part-circle are arranged in a first part of the segments, such that said filters are consecutively introduced into the detection beam path or illumination beam path when the filter wheel is rotated. A camera records images at a predefined frequency. The filter wheel device includes a motor-driven shaft that rotates the filter wheel at a predefined rotation frequency. The microscope also comprises a control system for synchronising the image-recording frequency and rotation frequency based on the filters arranged on the filter wheel. | 11-27-2014 |
20140347462 | QUANTITATIVE NONLINEAR OPTICAL MICROSCOPY USING A SHAPED BEAM - A nonlinear optical microscope is provided, including source of a pulsed laser beam; a spatial light modulator for modulating the spatial profile of the pulsed laser beam; an objective for guiding the modulated beam towards a slide intended to carry a specimen; and a detector for collecting signals originating from the specimen, wherein the spatial light modulator is designed to modulate the intensity and/or the phase of the pulsed laser beam on the rear pupil of the objective to produce a beam that is axially extended and confined in one or two lateral directions after focusing by the objective, and wherein the slide is placed on a motorized stage of a histology slide scanner assembly. | 11-27-2014 |
20140347463 | SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES - The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection. | 11-27-2014 |
20140354795 | LOW COST OPTICAL HIGH SPEED DISCRETE MEASUREMENT SYSTEM - Systems and methods are provided for determining a velocity or an inflation rate of a droplet in a microfluidic channel. The droplet is exposed to two or more temporally separated flashes of light, each flash including light of one wavelength band, and imaged using a detector configured to distinguish light in the wavelength bands. Two or more images of the droplet are acquired, each corresponding to one of the flashes, and all within a single video frame or photographic exposure. The images can be processed separately and the position or size of the droplet in each image is calculated. A velocity or inflation rate is then determined by dividing the change in position or size by the amount of time allowed to pass between the flashes. | 12-04-2014 |
20140354796 | Apparatus And Method For Transmitted Light Illumination For Light Microscopes And Microscope System - The invention relates to an apparatus for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, and a holding device for holding a sample to be examined, and at least one diaphragm edge for trimming the illuminating light beam bundle, wherein the diaphragm edge is arranged between the holding device and the light source and extends transversely to an optical axis, wherein a beam path of the illuminating light between the diaphragm edge and a sample held by the holding device is free from adjustable beam focussing components. The apparatus is characterized in that in order to adapt the beam path of the illuminating light to the effective entrance pupil of the objective, means are provided for variable positioning of the diaphragm edge in the direction of the optical axis, wherein a position of the diaphragm edge in the direction of the optical axis can be varied irrespectively of a position of the diaphragm edge transversely to the optical axis. The invention also relates to a method for transmitted light illumination for a light microscope and a microscope system. | 12-04-2014 |
20140362203 | Structured Illumination Projection With Enhanced Exposure Control - A method for controlling a structured illumination pattern generating portion is provided for illuminating a workpiece during an image acquisition by a camera in a precision machine vision inspection system. A controllable spatial light modulator (e.g., a digital light processing projector) is part of the generating portion for generating the structured illumination pattern. The pattern may comprise an array of stripes including a sinusoidal gray level intensity variation across each stripe. An overall image exposure is increased by repeating a complete structured illumination pattern generation iteration, including gray level variation, a plurality of times during an image integration period. Structured illumination microscopy techniques for determining a workpiece surface profile may benefit, wherein multiple (e.g., 3 or 4) images are acquired at respective focus positions to be analyzed, by using the method to project a different phase of a structured light pattern for each of the multiple images. | 12-11-2014 |
20140362204 | INFORMATION PROCESSING APPARATUS, IMAGING CONTROL METHOD, PROGRAM, DIGITAL MICROSCOPE SYSTEM, DISPLAY CONTROL APPARATUS, DISPLAY CONTROL METHOD, AND PROGRAM - Provided is an information processing apparatus including a detection unit configured to detect a failure requiring reimaging relating to an image captured using a digital microscope by evaluating the image, and a generation unit configured to, if the failure was detected by the detection unit, generate setting information for setting an imaging condition for during reimaging. | 12-11-2014 |
20140362205 | IMAGE FORMING APPARATUS AND CONTROL METHOD FOR THE SAME - The apparatus has a drive system that drives at least one of the imaging element and a holding member to change their positions, a drive control unit that drives the drive system, every time a small image is captured, in such a way that the positions of the imaging element and the holding member are set to predetermined positions, an obtaining unit that obtains, as after-driving position information, the position of at least one of the imaging element and the holding member after driving by the drive system by measurement or estimation, a correction unit that corrects deformation of the small images caused by a difference between the target imaging position and an actual imaging position on the basis of the after-driving position information, and a forming unit that forms an overall image of the object by stitching the small images after correction. | 12-11-2014 |
20140368631 | METHOD AND APPARATUS FOR DETERMINING A FOCAL POSITION OF AN IMAGING DEVICE ADAPTED TO IMAGE A BIOLOGIC SAMPLE - A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect includes the steps of: disposing lenslets within a biologic sample, which lenslets have a height and a refractive index, which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; imaging a portion of the sample including lenslets using transmittance at one or more wavelengths; determining an average light transmittance intensity of the sample at the wavelengths; determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets. | 12-18-2014 |
20140368632 | IMAGE PROCESSING APPARATUS, IMAGE DISPLAY SYSTEM, AND IMAGE PROCESSING METHOD AND PROGRAM - There is provided an image processing apparatus which can prevent the case where it is difficult to perform highly accurate diagnosis using combined boundary regions in a combined image. | 12-18-2014 |
20140375792 | SYSTEMS AND METHODS FOR SELF-REFERENCED QUANTITATIVE PHASE MICROSCOPY - Systems and methods of self-referenced quantitative phase microscopy (SrQPM). The SrQPM systems and methods provide single-shot, full-field imaging capability for increased imaging speed, and near-common-path geometry for increased phase stability, allowing the study of internal structures of biological cells, live cell dynamics, and the like. | 12-25-2014 |
20150009315 | MICROSCOPE APPARATUS - A microscope apparatus includes: a light source; an illumination optical system configured to illuminate a specimen with light from the light source, the illumination optical system having a spatial light modulation element capable of adjusting a light intensity distribution; an imaging optical system configured to image light from the specimen; a solid-state imaging device configured to generate an image of the specimen based on light from the imaging optical system; and a controller capable of adjusting the spatial light modulation element, the controller being configured to, based on a first image output from the solid-state imaging device when the specimen is illuminated with first illumination light, adjust the spatial light modulation element and illuminate the specimen with second illumination light. | 01-08-2015 |
20150022651 | Predictive Focusing for Image Scanning Systems - This invention discloses an apparatus for achieving predictive focusing in an image scanning system. The apparatus comprises an optical path-length changing plate and an image sensor. In one embodiment, the plate comprises a plurality of path-length changing members. The plate further includes a central region configured to provide a substantially constant change in optical path length across the central region, allowing an image passing therethrough to be in-focus captured. Having a light receiving surface, each path-length changing member is configured to provide a substantially non-uniform change in optical path length across the light receiving surface, allowing a focus plane of the image to be tilted such that the image projected onto the imaging sensor can be used for predicting an amount of optical adjustment required to achieve focusing. By using more than one path-length changing member, predictive focusing is achievable with more than one direction of focus-plane tilting. | 01-22-2015 |
20150022652 | DEVICE AND METHOD FOR INSPECTING A SEALING MEMBER - A sealing inspection device includes a scan unit through which a display device substrate including a top plate coupled to a bottom plate by a sealing member in the sealed area passes; and a photographing unit through which the display device substrate which has passed through the scan unit, further passes. The scan unit generates coordinate values of the sealed area of the display device substrate, detects a defective region in the sealed area of the display device substrate, and includes a plurality of scan cameras. The photographing unit generates an image of the sealed area of the display device substrate using the generated coordinate values, measures an effective sealing width of the sealed area using the generated image, and comprises a measuring camera. | 01-22-2015 |
20150022653 | IMAGE ACQUISITION DEVICE - A image acquisition device including a connection section having an opening; an optical-path switching unit that changes an optical path of light entering from the opening; and two image acquisition elements. The optical-path switching unit includes two parallel reflective surfaces disposed with a distance therebetween and is swivelable about a swivel axis such that the reflective surface is insertable into and withdrawable from an incident optical axis. The first image acquisition element is disposed on the incident optical axis at the opposite side of the opening with the optical-path switching unit interposed therebetween. The second image acquisition element is disposed at a position where the second image acquisition element acquires an image of the light that has been deflected by the two reflective surfaces and is tilted about central axes of the two image acquisition elements relative to a straight line extending orthogonally to the central axes. | 01-22-2015 |
20150029324 | SUBSTRATE INSPECTION METHOD, SUBSTRATE MANUFACTURING METHOD AND SUBSTRATE INSPECTION DEVICE - There is provided a substrate inspection method for inspecting a substrate having a plurality of holes formed on a plate-shaped material, including: an image acquisition step (S | 01-29-2015 |
20150029325 | HIGH RESOLUTION IMAGING OF EXTENDED VOLUMES - A light sheet optical system comprising means for forming a light sheet using a non-diffractive or quasi non-diffractive and/or propagation invariant beam that has an asymmetric intensity beam profile transverse to the direction of propagation, such as an Airy beam. | 01-29-2015 |
20150035964 | HIGH-RESOLUTION LUMINESCENCE MICROSCOPY - A microscopy method for producing a high-resolution image of a sample which includes furnishing the sample with a marker that emits statistically flashing luminescence radiation after excitation, or using a sample that has molecules that emit statistically flashing luminescence radiation after excitation. The sample is excited to luminescence in such a manner that the marker/molecules emit luminescence radiation flashing at a flash rate, wherein—the illumination is structured in such a manner that the flash rate varies locally and—the sample is repeatedly illuminated in different illumination states of the structured illumination. The luminescing sample is repeatedly imaged on a detector in each of the different illumination states. | 02-05-2015 |
20150035965 | METHOD FOR CALIBRATING A DIGITAL OPTICAL IMAGING SYSTEM HAVING A ZOOM SYSTEM, METHOD FOR CORRECTING ABERRATIONS IN A DIGITAL OPTICAL IMAGING SYSTEM HAVING A ZOOM SYSTEM, AND DIGITAL OPTICAL IMAGING SYSTEM - The invention relates to a method for calibrating a digital optical imaging system, comprising at least one motorized or coded zoom system and an image sensor, to a method for correcting aberrations in such an imaging system, and to an optical imaging system which is configured to carry out the methods according to the invention. During the calibration method, a reference object is recorded in various zoom settings and the image is corrected pixel-wise with digital-optical means using a previously determined model. To this end, distortion correction coefficients and image stability correction coefficients are ascertained. The real total magnification of the system is ascertained from the corrected image. The model ascertained in the calibration process also serves for correcting aberrations during operation of the imaging system. | 02-05-2015 |
20150042778 | METHOD AND OPTICAL DEVICE FOR SUPER-RESOLUTION LOCALIZATION OF A PARTICLE - A super-resolution microscopy method includes forming an image of an emitting particle in a detection plane of a detector by a microscopy imaging system and correcting, by a wavefront-modulating device, at least some of the optical defects present between the emitting particle and the detection plane. The method further includes introducing, via the wavefront-modulating device, a deformation of the wavefront emitted by the emitting particle, of variable amplitude, allowing a bijective relationship to be formed between the shape of the image of the emitting particle in the detection plane and the axial position of the emitting particle relative to an object plane that is optically conjugated with the detection plane by the microscopy imaging system. The method further includes controlling the amplitude of the deformation of the wavefront by controlling the wavefront-modulating device, as a function of the given range of values of the axial position of the particle. | 02-12-2015 |
20150042779 | DISK SCANNING APPARATUS AND MICROSCOPE APPARATUS - A disk scanning apparatus is used in combination with an imaging optical system and an imaging apparatus. The disk scanning apparatus includes a rotating disk and a relay optical system. In the rotating disk, a disk surface including a shielding part and a transmitting part is placed so as to be positioned on a focal plane of the imaging optical system. The relay optical system performs relaying of an optical image of a sample to the imaging apparatus. The relay optical system includes a front group having a positive power and a rear group having a positive power, in this order from the rotating disk side, and is configured so that a luminous flux between the front group and the rear group becomes an afocal luminous flux. The disk scanning apparatus further includes a structure configured to make the distance between the front group and the rear group variable. | 02-12-2015 |
20150042780 | 4F-BASED OPTICAL PHASE IMAGING SYSTEM - The invention relates to 4F-based optical phase imaging system and in particular to reconstructing quantitative phase information of an object when using such systems. The invention applies a two-dimensional, complex spatial light modulator (SLM) to impress a complex spatial synthesized modulation in addition to the complex spatial modulation impressed by the object. This SLM is arranged so that the synthesized modulation is superimposed with the object modulation and is thus placed at an input plane to the phase imaging system. By evaluating output images from the phase imaging system, the synthesized modulation is selected to optimize parameters in the output image which improves the reconstruction of qualitative and quantitative object phase information from the resulting output images. | 02-12-2015 |
20150042781 | NON-VECTOR SPACE SENSING AND CONTROL SYSTEMS AND METHODS FOR VIDEO RATE IMAGING AND MANIPULATION - Compressive sensing based video rate imaging techniques are presented. Rather than scan the entire image, the imaging system only scans part of the topography of the sample as a compressed scan. After the data has been collected, an algorithm for image reconstruction is applied for recovering the image. Because compressive sensing is used, the imaging rate is increased from several minutes per frame to seconds per frame. Non-vector space control techniques are also presented. No-vector space control use image or compressive data as the input and feedback to generate a closed-loop motion control. Compressive sensing technique provides an efficient data reduction method to retain the essential information in the original image. The non-vector space control method can be used as motion control method with compressive feedback without or with noise. | 02-12-2015 |
20150042782 | IMAGE PROCESSING APPARATUS, IMAGING APPARATUS, MICROSCOPE SYSTEM, IMAGE PROCESSING METHOD, AND COMPUTER READABLE RECORDING MEDIUM - An image processing apparatus includes: an image acquiring unit that acquires an image signal of a monochromatic image acquired by imaging a subject and an image signal of a color image acquired by imaging the subject, the color image having at least a plurality of pieces of color information; and an interpolation processing unit that generates an interpolated image by interpolating color information missing at each pixel forming the color image, based on a signal value of each pixel forming the monochromatic image. | 02-12-2015 |
20150054935 | PORTABLE TERMINAL ADAPTOR FOR MICROSCOPE, AND MICROSCOPIC IMAGING METHOD USING THE PORTABLE TERMINAL ADAPTOR - A portable terminal adaptor for a microscope may be provided in a microscope to capture an image observed under the microscope by means of a camera of a portable terminal. The portable terminal adaptor may include a lens-barrel attachment fixed to a lens-barrel of the microscope, a portable-terminal placing base having a first imaging hole through which the image observed under the microscope passes, the portable terminal being placed on the portable-terminal placing base, and a portable-terminal holder holding the portable terminal placed on the portable-terminal placing base. | 02-26-2015 |
20150054936 | OPTICAL SYSTEM FOR IMAGING AN OBJECT - An optical system for imaging an object comprises a first lens, a first image stabilization unit and a first image plane. When seen from the first lens in the direction of the first image plane, the order in which the elements are arranged along a first optical axis is as follows: first lens, first image stabilization unit and first image plane. The first image stabilization unit has at least one first inlet surface and at least one first outlet surface. The first inlet surface is oriented towards the first lens. The first outlet surface is oriented towards the first image plane. Furthermore, the first outlet surface is spaced apart from the first image plane in a range of 1 mm to 20 mm. | 02-26-2015 |
20150070483 | Double Fold Optics - An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region. | 03-12-2015 |
20150070484 | Observation Unit and Microscope System Equipped with Observation Unit - A microscope system ( | 03-12-2015 |
20150077535 | SYSTEMS AND METHODS FOR STRUCTURED ILLUMINATION SUPER-RESOLUTION PHASE MICROSCOPY - Systems and methods for structured illumination super-resolution phase microscopy are disclosed. According to an aspect, an imaging system includes a light source configured to generate light. The system also includes a diffraction grating positioned to receive and diffract the output light. The system also includes a sample holder positioned to receive the diffracted light for transmission through a sample. Further, the system includes an image detector positioned to receive the light transmitted through the sample and configured to generate image data based on the received light. The system also includes a computing device configured to apply subdiffraction resolution reconstruction to the image data for generating an image of the sample. | 03-19-2015 |
20150085098 | OBSERVATION APPARATUS, OBSERVATION PROGRAM, AND OBSERVATION METHOD - To provide an observation apparatus, an observation program, and an observation method that are suitable for the detection and observation of an observation target object. | 03-26-2015 |
20150097939 | METHOD AND APPARATUS FOR DETERMINING A FOCAL POSITION OF AN IMAGING DEVICE ADAPTED TO IMAGE A BIOLOGIC SAMPLE - A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect includes the steps of: disposing lenslets within a biologic sample, which lenslets have a height and a refractive index, which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; imaging a portion of the sample including lenslets using transmittance at one or more wavelengths; determining an average light transmittance intensity of the sample at the wavelengths; determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets. | 04-09-2015 |
20150097940 | ORTHOGONAL LIGHT BEAM SPLITTING FOR MICROSCOPES - A system comprises a first beamsplitter module and a second beamsplitter module aligned with the first beamsplitter module along an alignment line. In certain embodiments, each beamsplitter module can split a beam traveling along a first optical path into a first split beam and a second split beam within a spectral range. Each beamsplitter module can transmit the first split beam along the first optical path and direct the second split beam along a second optical path substantially orthogonal to the first optical path and to the alignment line. In certain embodiments, each beamsplitter module can receive a first beam traveling along a first optical path and a second beam traveling along a second optical path that is substantially orthogonal to the first optical path and to the alignment line. Each beamsplitter module can combine the second beam with the first beam to yield a combined beam and transmit the combined beam along the first optical path. | 04-09-2015 |
20150097941 | APPARATUS FOR HIGH-THROUGHPUT POLLEN EXTRACTION AND COUNTING - An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed. | 04-09-2015 |
20150103156 | SYSTEM AND METHOD FOR CONTROLLING A TRACKING AUTOFOCUS (TAF) SENSOR IN A MACHINE VISION INSPECTION SYSTEM - A method is provided for controlling a Tracking AutoFocus (TAF) portion of a machine vision inspection system including an imaging portion, a movable workpiece stage, a control portion, and graphical user interface (GUI). The TAF portion automatically adjusts a focus position of the imaging portion to focus at a Z height corresponding to a current surface height of the workpiece. The method includes providing the TAF portion, and providing TAF enable and disable operations, wherein: the TAF disable operations comprise a first set of TAF automatic interrupt operations that are automatically triggered by user-initiated operations that include changing the Z height, and the TAF disable operations may further comprise automatic interrupt operations that are automatically triggered based on at least one respective TAF Z height surface tracking characteristic exceeding a previously set TAF disable limit for that respective TAF Z height surface tracking characteristic. | 04-16-2015 |
20150103157 | COLOR DEGRADATION COMPENSATION METHOD - A color degradation compensation method is provided. The color degradation compensation method includes the steps as follows. Two images are captured by an image capturing device, wherein the two images have an overlapped area. A calculating procedure is constructed. At least one position in the overlapped area is selected and color values of a plurality of points in the position on each of the two images are read, wherein the points of each image are corresponded to the same position in the overlapped area. A ratio of the two color values is calculated. A degradation standard deviation of the two color values is calculated by the calculating procedure. The color values of the two images are calibrated to compensated color values through the calculating procedure in accordance with the degradation standard deviation. | 04-16-2015 |
20150109430 | DIGITAL IMAGING SYSTEM FOR BIOPSY INSPECTION - A self-illuminating microscope slide with a biopsy specimen disposed thereon comprises LEDs on the ends of the slide to illuminate the specimen through total internal reflection. A camera device captures a single digital image of the entire specimen in high resolution and large field of view encompassing the specimen. | 04-23-2015 |
20150109431 | Systems and Methods for Material Texture Analysis - The present inventions are related to systems and methods for determining characteristics of a material. The characteristics may include, but are not limited to, crystallographic texture. | 04-23-2015 |
20150109432 | Scanner With Increased Dynamic Range - An instrument and method for scanning all or part of a large specimen mounted on a specimen holder takes a plurality of measurements of each pixel in the whole or part of the specimen being scanned at a plurality of exposure values. A computer controls the movement of the specimen holder during scanning and again of the detector to produce a digitized image of all or part of the specimen with larger dynamic range than the dynamic range of the detection system. In a further embodiment, the instrument can scan two successive, identical strips at a different exposure values and combine the images from the two scans into one digitized image having a larger dynamic range than the dynamic range of the detection system. | 04-23-2015 |
20150116475 | IMAGE CAPTURING APPARATUS AND FOCUSING METHOD THEREOF - In the image capturing apparatus, the optical path difference producing member is disposed on the second optical path. Thereby, at the second imaging device, it is possible to suppress the amount of light on image pickup of an optical image which is focused at the front of an optical image made incident into the first imaging device (front focus) and on image pickup of an optical image which is focused at the rear thereof (rear focus) and also to secure the amount of light on image pickup by the first imaging device. Further, in the image capturing apparatus, based on a scanning velocity v of the stage and an interval d between the first imaging region and the second imaging region, a waiting time is set from image pickup at the first imaging region to image pickup at the second imaging region. As a result, light from the same position of the sample is made incident into the first imaging region and the second imaging region. Thus, it is possible to control a focus position at high accuracy. | 04-30-2015 |
20150116476 | Microscopic Imaging Device, Microscopic Imaging Method, And Microscopic Imaging Program - To provide a microscopic imaging device in which a measuring object can be easily imaged using measurement light having a desired pattern, in which the pattern of measurement light can be changed and a phase of the pattern can be moved, without arranging a mechanical mechanism. An arbitrary pattern of a plurality of patterns of measurement light is instructed. The measurement light having an instructed pattern is generated by a light modulation element, and is applied on a measuring object. A spatial phase of the generated pattern is sequentially moved on the measuring object by a predetermined amount by the light modulation element. A plurality of pieces of pattern image data generated at a plurality of phases of the pattern is synthesized based on the light receiving signal output from the light receiving section to generate sectioning image data indicating an image of the measuring object. | 04-30-2015 |
20150116477 | Microscopic Imaging Device, Microscopic Imaging Method, and Microscopic Imaging Program - To provide a microscopic imaging device, a microscopic imaging method, and a microscopic imaging program capable of detecting a focused position through an appropriate method corresponding to the imaging method. In a sectioning observation, a measuring object is irradiated with pattern measurement light, and sectioning image data is generated. In a normal observation, the measuring object is irradiated with uniform measurement light to generate normal image data. Relative positions of an objective lens and the stage are changed a plurality of times in an optical axis direction of the objective lens by a focus position adjustment mechanism. When the sectioning observation is instructed, a focused position is detected based on the value of each piece of pixel data of the sectioning image data. When the normal observation is instructed, a focused position is detected based on a local contrast of the normal image data. | 04-30-2015 |
20150116478 | Microscopic Imaging Device, Microscopic Imaging Method, And Microscopic Imaging Program - To provide a microscopic imaging device capable of easily switching the imaging method. During sectioning observation and normal observation, a measuring object is irradiated with pattern measurement light and uniform measurement light generated by a light modulation element, respectively. The measuring object is irradiated with the pattern measurement light and the uniform measurement light through a common light path. During the sectioning observation, a spatial phase of the pattern is sequentially moved on the measuring object by a predetermined amount by the light modulation element, and sectioning image data indicating an image of the measuring object is generated based on a plurality of pieces of image data generated at a plurality of phases of the pattern based on the light receiving signal. During the normal observation, normal image data indicating an image of the measuring object is generated based on the light receiving signal. | 04-30-2015 |
20150124072 | SYSTEM AND METHOD FOR COLOR CORRECTION OF A MICROSCOPE IMAGE - A system and method for correcting the color of microscope images is described wherein a microscope, equipped with a variable light source and at least one microscope setting selector operates in conjunction with an image recording device having at least one image setting selector with a plurality of settings, and is configured to record at least one white balanced sample image of a sample. The system and method also includes the use of at least one white balanced calibration image of an integral transmissive color filter array of known transmission values in combination with an image processor executing code in order to color calibrate the sample images based on the calibration image. | 05-07-2015 |
20150124073 | ILLUMINATION OPTICAL SYSTEM AND MICROSCOPE - The illumination optical system is configured to illuminate a sample placed on an object plane with light. The illumination optical system includes multiple light source areas which are mutually coherent and arranged separately from one another in a pupil plane of the illumination optical system. Among distances from a center of a pupil of the illumination optical system to centers of the multiple light source areas, at least one of the distances is different from the other distances. | 05-07-2015 |
20150124074 | IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION METHOD - An image acquisition apparatus includes first and second imaging elements, an image formation optical system, a subject stage that supports a subject, and a control unit. The image formation optical system forms an image of the subject on light-receiving surfaces of the first and second imaging elements. The control unit acquires imaging results by imaging a correction mark disposed on the subject stage while changing a relative position between the first imaging element and the correction mark in an optical axis direction of the image formation optical system. The control unit moves, in accordance with the imaging results, the first imaging element or subject stage in the optical axis direction so the first imaging element and the correction mark are conjugate, acquires an imaging result by imaging the correction mark, and moves, in accordance with the acquired imaging result, the second imaging element in the optical axis direction. | 05-07-2015 |
20150124075 | OPTICAL IMAGING DEVICE AND IMAGING METHOD FOR MICROSCOPY - An optical zoom device for setting an imaging scale of an imaging device, which is configured for imaging an object on an image plane of an image recording device using a microscope objective, comprising an optical element arrangement is disclosed. The optical element arrangement includes an object-side zoom entrance for optical connection to an objective exit, in particular a collimated objective exit, of the microscope objective and includes an image-side zoom exit for optical connection to an image recording entrance of the image recording device. The optical element arrangement includes a tele arrangement designed according to the teleobjective principle, which includes a first optical element group with negative refractive power and a second optical element group with positive refractive power, assigned to the first optical element group for setting the imaging scale, wherein the first optical element group is arranged at the zoom exit and the second optical element group is arranged on the objective side of the first optical element group. | 05-07-2015 |
20150124076 | SOLID-STATE MICROSCOPE FOR SELECTIVELY IMAGING A SAMPLE - Exemplary embodiments provide solid-state microscope (SSM) devices and methods for processing and using the SSM devices. The solid-state microscope devices can include a light emitter array having a plurality of light emitters with each light emitter individually addressable. During operation, each light emitter can be biased in one of three operating states including an emit state, a detect state, and an off state. The light emitter can include an LED (light emitting diode) including, but not limited to, a nanowire based LED or a planar LED to provide various desired image resolutions for the SSM devices. In an exemplary embodiment, for near-field microscopy, the resolution of the SSM microscope can be essentially defined by the pitch p, i.e., center-to-center spacing between two adjacent light emitters, of the light emitter array. | 05-07-2015 |
20150130920 | REAL-TIME FOCUSING IN LINE SCAN IMAGING - Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor. | 05-14-2015 |
20150130921 | IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD - An image processing apparatus includes an image acquisition unit, a visual field information generation unit, and a display controller. The image acquisition unit is configured to acquire an input image having a first resolution, the input image being generated by capturing an observation image of an observation target of a user. The visual field information generation unit is configured to compare a specimen image with the input image, the specimen image including an image of the observation target and having a second resolution that is higher than the first resolution, to generate visual field information for identifying a visual field range corresponding to the input image in the specimen image. The display controller is configured to acquire information corresponding to the visual field range in the specimen image, based on the visual field information, and output a signal for displaying the information. | 05-14-2015 |
20150130922 | OBJECTIVE OPTICAL SYSTEM AND IMAGE ACQUISITION APPARATUS - The objective optical system includes a first optical system configured to collimate a divergent light flux from an object, a second optical system configured to converge the light flux from the first optical system, a beam splitter disposed between the first optical system and the second optical system, a reflector disposed on a side where the light flux from the second optical system is condensed and configured to reflect the light flux, and a third optical system configured to converge the light flux reflected by the reflector and then passing through the second optical system and the beam splitter. When a direction in which the light flux travels in the objective optical system is defined as an optical axis direction, positions of respective portions of the reflector in the optician axis direction are each changeable. | 05-14-2015 |
20150138334 | IMAGE PROCESSING DEVICE, PROGRAM, IMAGE PROCESSING METHOD, COMPUTER-READABLE MEDIUM, AND IMAGE PROCESSING SYSTEM - An image processing device | 05-21-2015 |
20150145980 | Machine Vision Inspection System and Method for Obtaining an Image With an Extended Depth of Field - A method for operating an imaging system of a machine vision inspection system to provide an extended depth of field (EDOF) image. The method comprises (a) placing a workpiece in a field of view; (b) periodically modulating a focus position of the imaging system without macroscopically adjusting the spacing between elements in the imaging system, the focus position is periodically modulated over a plurality of positions along a focus axis direction in a focus range including a workpiece surface height; (c) exposing a first preliminary image during an image integration time while modulating the focus position in the focus range; and (d) processing the first preliminary image to remove blurred image contributions occurring in the focus range during the image integration time to provide an EDOF image that is focused throughout a larger depth of field than the imaging system provides at a single focal position. | 05-28-2015 |
20150293270 | DETECTION OF MICROSCOPIC OBJECTS - A substrate for use in manufacture of a production master plate for production of a detection disc for carrying samples in an apparatus for detection of microscopic objects in a fluid, the substrate having a channel and separate focus structure, wherein the focus structure is a groove. | 10-15-2015 |
20150301323 | SYSTEM FOR SETTING ANALYSIS TARGET REGION - A system for setting, within an observed image of a sample, an analysis target region that is a region on which an analysis is to be performed by an analyzer, the system including: a characteristic quantity calculator for dividing the observed image into a plurality of areas and for calculating a predetermined image characteristic quantity in each of the divisional areas; a divisional area selector for allowing a user to select a plurality of the divisional areas; a characteristic quantity range calculator for determining a value range of the image characteristic quantity for the divisional areas to be extracted as the analysis target region, based on the values of the image characteristic quantity of the divisional areas selected through the divisional area selector; and an area extractor for extracting, from the observed image, each divisional area having a value of the image characteristic quantity included in the aforementioned value range. | 10-22-2015 |
20150301324 | CHARGE GRADIENT MICROSCOPY - A method for rapid imaging of a material specimen includes positioning a tip to contact the material specimen, and applying a force to a surface of the material specimen via the tip. In addition, the method includes moving the tip across the surface of the material specimen while removing electrical charge therefrom, generating a signal produced by contact between the tip and the surface, and detecting, based on the data, the removed electrical charge induced through the tip during movement of the tip across the surface. The method further includes measuring the detected electrical charge. | 10-22-2015 |
20150301327 | IMAGE CAPTURING APPARATUS AND IMAGE CAPTURING METHOD - An image capturing apparatus is configured to store the control result of a focus position during scanning of segmented regions and determine an initial focus position in scanning of the (n+1)th segmented region, based on the control result stored during scanning of the nth (n is an integer of 1 or more) or earlier segmented region. The foregoing technique allows this image capturing apparatus to roughly determine the initial focus position in the next-scanned segmented region by making use of the control result of the segmented region the scanning of which has been already completed. This can suppress increase in processing time necessary for imaging, by simplification of pre-focus. | 10-22-2015 |
20150301328 | SYSTEM AND METHOD OF ACQUIRING IMAGES WITH A ROLLING SHUTTER CAMERA WHILE ASYNCHRONOUSLY SEQUENCING MICROSCOPE DEVICES - A computer-implemented method and an image acquisition system for synchronizing movement of a device associated with a microscope and acquisition of images from a camera associated with the microscope. An exposure signal is received from the camera associated with the microscope. The exposure signal is analyzed to identify a period of time when the device associated with the microscope may be moved. In addition, image data associated with the exposure signal is received. Further a command is issued to the device associated with the microscope to move the device associated with the microscope to a new position during the identified period of time. | 10-22-2015 |
20150309299 | IMAGING APPARATUS, MICROSCOPE SYSTEM, AND IMAGING METHOD - An imaging apparatus includes: a stage; an imaging unit having an imaging surface for receiving observation light from an object on the stage; a first moving mechanism for performing a relative movement between the stage and the imaging unit along at least one direction within a placement plane for placing the object; a second moving mechanism for performing a relative movement between the stage and the imaging unit along a direction orthogonal to the placement plane; a computation unit that causes the imaging unit to image a first region of the object while operating the first moving mechanism to acquire information on the first region, and calculates a focus tendency of the object; and a control unit that controls the second moving mechanism based on the focus tendency, and adjusts an imaging characteristic of the observation light when the imaging unit images a second region of the object. | 10-29-2015 |
20150309300 | IMAGE PICKUP APPARATUS, IMAGE PICKUP SYSTEM, AND IMAGE PROCESSING METHOD - An image pickup apparatus includes an illumination optical system configured to illuminate a specimen, an imaging optical system configured to form an optical image of the specimen, a light modulator configured to generate at least one of a transmittance distribution and a phase distribution which are asymmetric with respect to an optical axis on a pupil plane of at least one of the illumination optical system and the imaging optical system, an image sensor configured to photoelectrically convert the optical image of the specimen formed by the imaging optical system, and a driver configured to change a relative position along an optical axis direction of the imaging optical system between a focal plane of the imaging optical system and at least one of the specimen and the image sensor. The driver changes the relative position in acquiring a plurality of images of the specimen. | 10-29-2015 |
20150309301 | IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, IMAGE FORMING SYSTEM, AND RECORDING MEDIUM - An image forming apparatus includes an imager that is electrically connected to an image sensor disposed at a position where light that has passed through a sample slice is incident on the image sensor, and an illumination system that emits illumination light successively in different illumination directions relative to a sample slice to illuminate the sample slice with the illumination light and that emits a first light having a peak in a first wavelength range and a second light having a peak in a second wavelength range. The image forming apparatus obtains a plurality of first-color images with the image sensor while the sample slice is being illuminated with the first light serving as the illumination light successively in the different illumination directions. The image forming apparatus obtains at least one second-color image with the image sensor while the sample slice is being illuminated with the second light in at least one of the different illumination directions. The image forming apparatus generates a high-resolution image on the basis of the plurality of first-color images and the at least one second-color image. | 10-29-2015 |
20150317507 | DEVICE AND METHOD FOR MICROSCOPY ON A PLURALITY OF SAMPLES - The present invention relates to a device and a method for microscopy ( | 11-05-2015 |
20150317824 | SAMPLE IMAGE DATA GENERATING APPARATUS AND SAMPLE IMAGE DATA GENERATING METHOD - A sample image data generating apparatus includes a modulated image imager that picks up a modulated image that is a sample image modulated by structured illumination forming an illumination pattern having a periodic structure in an optical axis direction of an objective and an orthogonal direction orthogonal to the optical axis direction. The sample image data generating apparatus further includes a demodulated image data generator that generates demodulated image data by calculating a demodulated image according to a plurality of modulated images each picked up by the modulated image imager when the illumination pattern is located at a different position on sample with respect to the optical axis direction and the orthogonal direction and according to a defocusing amount of the structured illumination with reference to a focal plane of the objective, the demodulated image being a sample image obtained by demodulating the modulated image. | 11-05-2015 |
20150320512 | Registration Correction based on Shift Detection in Image Data - The invention relates to a data processing method of determining a positional transformation (T, M) for correcting the registration of an anatomical body part with a medical imaging apparatus, the method being executed by a computer and comprising the following steps: a) acquiring initial body part position data comprising initial body part position information describing an initial relative position ( | 11-12-2015 |
20150323773 | Five Axis Optical Inspection System - An inspection system that is effective to collect images of a part under inspection. This inspection system includes (a) a three axis linear motion stage; (b) a rotary fourth axis stage configured to hold and rotate an object to be inspected. This rotary fourth axis stage is mounted on the three axis linear stage; (c) a fifth axis camera and optical system mounted to one of the axes of the three axis linear motion stage. This fifth axis camera has an optical axis substantially parallel to the axis of linear motion; (d) a 45 degree mirror configured to bend the optical axis of the fifth axis camera by 90° to point towards the object; and (e) a motor configured to rotate the mirror over a range of angles to obtain a fifth axis of viewing orientation. | 11-12-2015 |
20150323776 | SPECIMEN PROCESSING SYSTEMS AND METHODS FOR HOLDING SLIDES - At least some embodiments of the technology are directed to an automated slide processing apparatus configured to apply at least one reagent to a specimen carried by a microscope slide. The slide processing station can include a support element with a support surface, at least one vacuum port, and a sealing member having a non-round shape. In an uncompressed state, the sealing member can extend upwardly beyond the support surface. In a compressed state, the sealing member can be configured to maintain an airtight seal with a backside of the microscope slide as the microscope slide is pulled against the support surface by a vacuum drawn via the at least one vacuum port. | 11-12-2015 |
20150323787 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DEPTH OF FIELD IMAGING FOR THREE-DIMENSIONAL SENSING UTILIZING A SPATIAL LIGHT MODULATOR MICROSCOPE ARRANGEMENT - Spatial Light Modulator (SLM) microscopy can customize a sample illumination pattern from the microscope to simultaneously interrogate multiple targets localized within the sample. An exemplary SLM microscope arrangement can be used to image target locations at, e.g., arbitrary 3D coordinate by using, e.g., an extended Depth-of-Field computational imaging system. Multi-site three-dimensional targeting and sensing can be used in both transparent and scattering media. To that end, exemplary embodiments of system, method and computer-accessible medium can be provided for generating at least one image of at least one portion of a sample. For example, a computer hardware arrangement corn be provided. Such exemplary arrangement can be configured to receive information related to light, modified by the sample, after being previously manipulated by a optical addressing (e.g., diffraction) arrangement. Such exemplary computer hardware arrangement can also generate the image(s) based on the information. | 11-12-2015 |
20150330892 | Analysis of Action Potentials, Transients, and Ion Flux in Excitable Cells - Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell. | 11-19-2015 |
20150331228 | PTYCHOGRAPHY IMAGING SYSTEMS AND METHODS WITH CONVEX RELAXATION - Certain aspects pertain to ptychographic imaging systems and methods with convex relaxation. In some aspects, a ptychographic imaging system with convex relaxation comprises one or more electromagnetic radiation sources, a digital radiation intensity detector, and a processor in communication with the digital radiation detector. The electromagnetic radiation provides coherent radiation to a specimen while the digital radiation intensity detector receives light transferred from the sample by diffractive optics and captures intensity distributions for a sequence of low resolution images having diversity. The processor generates a convex problem based on the sequence of low resolution images and optimizes the convex problem to reconstruct a high-resolution image of the specimen. In certain aspects, the convex problem is relaxed into a low-rank formulation. | 11-19-2015 |
20150346473 | SURGICAL MICROSCOPY SYSTEM AND METHOD FOR OPERATING THE SAME - A surgical microscopy system includes a surgical microscope with a control device and with focusable imaging optics for observing an operation field. The microscope is arranged on a stand with a base unit. The stand is embodied with linear drives and/or rotary joints in such a way that the surgical microscope is displaceable along three direction axes and rotatable about three axes of rotation relative to the base unit. For renewed focusing to a desired point, position and/or rotational sensors are assigned to each of the drives and/or joints for each of the direction axes and position and/or rotary angle sensors are assigned to each of the drives and/or joints for each of the axes of rotation and a focusing sensor for a focal point is assigned to the focusing imaging optics. A position and alignment of the microscope relative to the base unit and the focal point are storable. | 12-03-2015 |
20150346477 | NEAR FIELD LENS AND IMAGING APPARATUS INCLUDING SAME - A near field light includes a substrate; and an epsilon near zero (ENZ) material layer, which is arranged on the substrate and is formed of a material with a dielectric constant that includes a real part having a value of zero or a value very close to zero with respect to a light of a designated wavelength. | 12-03-2015 |
20150355445 | Optical System and Optical Instrument, Image Pickup Apparatus, and Image Pickup System Using the Same - An optical system which forms an optical image on an image pickup element, comprising in order from an object side,
| 12-10-2015 |
20150355449 | High Throughput Multichannel Fluorescence Microscopy with Microlens Arrays - A microscope includes a multi-wavelength emitting laser light source. A microscope objective is configured to receive and expand input light emitted from the light source, and a dichroic mirror is configured to reflect the expanded input light. A micro lens array with a plurality of micro lenses splits the reflected and expanded input light onto a fluorescence producing sample. A lens collectively captures the fluorescence for each micro lens in the plurality of micro lenses, and a camera receives the fluorescence from the lens and produces an image of the sample based on the received fluorescence. | 12-10-2015 |
20150355450 | OBSERVATION DEVICE, SIGNAL OUTPUT METHOD AND COMPUTER READABLE RECORDING MEDIUM - The present application provides an optical observation device having a first optical axis and a second optical axis different in direction from the first optical axis, the observation device including a splitter configured to split image light into first light along the first optical axis and second light along the second optical axis, the image light representing an image of an observation target; and a magnifier configured to change optical magnification for at least one of a first image represented by the first light and a second image represented by the second light. The splitter includes a first area, which receives the image light, and a second area, which receives the image light next to the first area. The first and second areas allow partial passage of the image light to generate the first light. The first area partially reflects the image light to generate the second light. | 12-10-2015 |
20150371368 | SAMPLE OBSERVATION APPARATUS AND METHOD FOR GENERATING OBSERVATION IMAGE OF SAMPLE - A good super-resolution image can be generated, while eliminating a troublesome task necessary for generating a raw image. Provided is a sample observation apparatus including a memory, which stores a first number of photoelectrons required in a raw image for generating a super-resolution image, and a main controller, which calculates the number of image data sets to be added together for generating the raw image based on the first number of photoelectrons stored in the memory and a predetermined image acquisition condition, which acquires multiple sets of image data of the same region of a sample by repeatedly detecting light from the same region based on the calculated number of image data sets, and which generates the raw image by adding together the acquired multiple sets of image data of the same region. | 12-24-2015 |
20160004902 | NETWORK-BASED PATHOLOGY SYSTEM WITH DESKTOP SLIDE SCANNER - A method for processing, saving and viewing a digital image of a microscope slide includes inserting a microscope slide into a digital slide scanner connected to an acquisition computer. A pre-scan formed from a plurality of image tiles uploaded to a network server while the pre-scan is being generated. The network server analyzes the image tiles in realtime to identify an area of interest. The acquisition computer generates a high magnification local scan of the area of interest. The local scan is formed from a plurality of local image tiles that are uploaded to the network server while the local scan is being generated. Each local image tile is viewable by a client computer in communication with the computer network while the plurality of local image tiles is being uploaded. A raw final image is then saved on the network server independent of the acquisition computer. | 01-07-2016 |
20160006928 | SYSTEMS AND METHODS FOR SAMPLE USE MAXIMIZATION - The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis. | 01-07-2016 |
20160029000 | Image Recording System with a Rapidly Vibrating Global Shutter CMOS Sensor - Image recording system, having: a digital camera with a two-dimensional global shutter CMOS sensor array with photosensitive sensor elements; shifting means, which are configured to produce a relative shifting between an object image and the sensor array between two positions; and a control unit, which is configured to control the shifting means between the recording of successive partial images, taking into account a color mosaic filter placed in front of the sensor elements for the simultaneous recording of a red, green, and blue color separation in such a way that by means of successive partial images recorded at the two positions for all image points of an image obtained by combining the partial images, color information for green is available; and an image processing unit, which is coupled to the digital camera and is configured to calculate a result image or a result image sequence, which includes at least two result images, based on at least three successive partial images. | 01-28-2016 |
20160033751 | OBSERVATION METHOD USING MICROSCOPIC IMAGING DEVICE - A certain embodiment provides an observation method using a microscopic imaging device which has a solid-state imaging device having a plurality of pixels arranged at predetermined intervals, each of the pixels including a microlens configured to collect light, and a light receiving unit configured to receive the light collected by the microlens. The observation method includes mounting an object to be observed on the microlenses or above the microlenses by disposing a specimen containing the object to be observed on the microscopic imaging device, and imaging the object to be observed, mounted on the microlenses or above the microlenses by a solid-state imaging device. | 02-04-2016 |
20160033752 | MICROSCOPY IMAGING DEVICE WITH ADVANCED IMAGING PROPERTIES - Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm | 02-04-2016 |
20160033753 | IMAGE ACQUIRING APPARATUS - An image acquiring apparatus configured to acquire an image of an object, including: an imaging optical system; an image taking element; a changing mechanism configured to change a posture of the object or the image taking element; a control unit configured to calculate a control target value; and a correcting mechanism configured to correct the posture such that a reached posture approaches the target posture, wherein the control unit compares reached image data obtained as a result that the image taking element actually takes an image of a correction chart whereof drawing information is known in a state that the posture is the reached posture, and target image data which is expected to be obtained when the image taking element takes an image of the correction chart in a state that the posture is the target posture to calculate a correction value of the posture. | 02-04-2016 |
20160041375 | ULTRA-COMPACT MICROSCOPE WITH AUTOFOCUSING - An ultra-compact microscope configured to image at least a portion of a biological sample is provided. The ultra-compact microscope includes an illumination source configured to provide illumination beams to image at least the portion of the biological sample. The ultra-compact microscope further includes an image sensor configured to acquire emitted signals from at least the portion of the biological sample. Moreover, the ultra-compact microscope includes an objective lens operatively coupled to the image sensor and configured to direct emitted signals from the biological sample to the image sensor. Additionally, the ultra-compact microscope includes a micro-motion control assembly operatively coupled to the image sensor and configured to provide dynamic translational motion, dynamic tilting motion, or both to the image sensor at least during scanning of the biological sample. | 02-11-2016 |
20160041380 | IMAGE-BASED LASER AUTOFOCUS SYSTEM - Accurate, reliable, and robust laser-based autofocus solutions are presented for through-the-lens microscope applications using slides or micro-titer plates. The laser-based autofocus solutions solve many of the problems that have arisen due to multiple reflective surfaces at varying distances relative to a sample of interest. The laser-based autofocus solutions provide a unique solution to resolve the ambiguity caused by these multiple reflective surfaces by using an image-based approach. | 02-11-2016 |
20160044212 | HIGH-THROUGHPUT SINGLE-CELL IMAGING, SORTING, AND ISOLATION - The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel. | 02-11-2016 |
20160048011 | SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD - A sample observation device includes an illumination optical system and an observation optical system, and the illumination optical system includes a light source, a condenser lens and an aperture member, and the observation optical system includes an objective lens and an imaging lens, and the aperture member has a light-shielding part or a darkening part and a transmission part, and the aperture member is disposed so that the light-shielding part or the darkening part includes an optical axis of the illumination optical system, and an image of an inner edge of the transmission part is formed inside of an outer edge of the pupil of the objective lens, and an image of an outer edge of the transmission part is formed outside of the outer edge of the pupil of the objective lens. | 02-18-2016 |
20160054555 | HIGH NUMERICAL APERTURE TELEMICROSCOPY APPARATUS - An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants. | 02-25-2016 |
20160054560 | LOUPE WITH ATTACHED CAMERA - A system and method for capturing a portion of the visual field of a loupe comprising: a loupe with at least one attached camera, a first computational device in communication with the camera, and software for operation on the first device; wherein the at least one camera captures visual data comprising a portion of the visual field of the loupe to form a capture and transmits the capture to the device for manipulation by the software. | 02-25-2016 |
20160062100 | LIGHT-FIELD MICROSCOPY WITH PHASE MASKING - Various aspects of the present disclosure are directed toward optics and imaging. As may be implemented with one or more embodiments, an apparatus includes one or more phase masks that operate with an objective lens and a microlens array to alter a phase characteristic of light travelling in a path from a specimen, through the objective lens and microlens array and to a photosensor array. Using this approach, the specimen can be imaged with spatial resolution characteristics provided via the altered phase characteristic, which can facilitate construction of an image with enhanced resolution. | 03-03-2016 |
20160062102 | STRUCTURED ILLUMINATION MICROSCOPE APPARATUS AND AN IMAGE FORMING APPARATUS - Polarized light which is emitted from an optical fiber becomes circular polarized light by passing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light. | 03-03-2016 |
20160063307 | IMAGE ACQUISITION DEVICE AND CONTROL METHOD THEREFOR - The image acquisition device has a stage that supports the sample, and an imaging unit that has an image forming optical system forming an image of the sample and captures the formed image. The image acquisition device further includes a specimen information acquisition unit that acquires information on presence or absence of a specimen included in the sample based on an imaging result of the imaging unit, and a control unit that moves the stage based on the information on the presence or absence of the specimen. | 03-03-2016 |
20160070092 | METHOD AND DEVICE FOR FLUORESCENT IMAGING OF SINGLE NANO-PARTICLES AND VIRUSES - A field-portable fluorescence imaging platform is disclosed that is installed on mobile communications device for imaging of individual nanoparticles or microparticles such as viruses, bacterial, and the like using a light-weight and compact opto-mechanical attachment or housing configured to be removably secured to the mobile communication device. The housing includes a sample holder configured to hold a sample along with a light source and a lens or lens system that is positioned generally opposite the lens in the mobile communication device. An optical filter is disposed in the housing and is interposed between the lens of the housing and the lens of the mobile communication device. A z-adjust stage is disposed in the housing and coupled to the sample holder, the z-adjust stage is configured to adjust the position of the sample holder in a z direction along an optical path passing through the lenses and onto an image sensor contained in the mobile communication device. | 03-10-2016 |
20160077321 | BIOLOGICALLY INSPIRED ALGORITHM BASED METHOD FOR NEAR REAL-TIME TRACKING OF MOVING OBJECTS IN THREE DIMENSIONAL ENVIRONMENT - A method for tracking three-dimensional movement of an object and focusing thereon is provided. Software repeatedly detects three-dimensional locations of one or more objects and image quality by sampling images at many parameter settings as the objects move in three-dimensional environment. The images are ranked occurring to a fitness score and parameter settings for subsequent images to established using a biologically-inspired algorithm. | 03-17-2016 |
20160080632 | IMAGE ACQUISITION DEVICE AND METHOD AND SYSTEM FOR CREATING FOCUS MAP FOR SPECIMEN - An image acquisition device reciprocates a focal position of an objective lens with respect to a sample in the optical axis direction of the objective lens, while moving a field position of the objective lens with respect to the sample. This makes it possible to acquire contrast information of image data at the field position of the objective lens sequentially as the field position moves with respect to the sample. The image acquisition device acquires the image data by the rolling readout of the image pickup element according to the reciprocation of the focal position of the objective lens. | 03-17-2016 |
20160085078 | LASER DIODE UNIFORM ILLUMINATOR - A fluorescence imaging system including a light source, an optical system, camera and an excitation light filter, the optical system produces a non-uniform fluence excitation illumination beam for illuminating an object and promoting fluorescence emissions, the optical system is positioned between the light source and the object, the optical system modifies the non-uniform fluence illumination beam into a uniform fluence illumination beam and changes the divergence of the uniform fluence illumination beam, the camera has an array of pixels, the camera detects the fluorescence emissions and performs pixel intensity measurements for each of the pixels, the excitation light filter is positioned between the object and the camera and filters out the excitation illumination beam, such that the excitation illumination beam does not reach the camera. | 03-24-2016 |
20160091702 | MEDICAL OPTICAL OBSERVATION INSTRUMENT AND METHOD FOR CONTRASTING POLARIZATION-ROTATING TISSUE - A medical optical observation instrument including an illumination system, which provides an illumination beam path for illuminating an observation object with illumination light, an observation system, which provides an observation beam path for observing the observation object and at least one camera for recording a digital image of the observation object, and a device for contrasting polarization-rotating tissue in the observation object. The device for contrasting polarization-rotating tissue in the observation object includes at least one illumination apparatus, arranged in the illumination system, including a polarization portion, at least one linear analyzer, arranged in the observation system and rotatable about the optical axis of the observation beam path, an image processing apparatus connected to the at least one camera, and an optimization apparatus connected to the image processing apparatus and to the at least one rotatable linear analyzer and the polarization portion. | 03-31-2016 |
20160091704 | Mid-Infrared Scanning System - An apparatus and method for generating a mid-infrared region image of a specimen are disclosed. The apparatus includes a mid-infrared region laser that generates a first light beam, and a stage adapted to carry a specimen to be scanned. An optical assembly focuses the first light beam to a point on the specimen. A first light detector measures a first intensity of light leaving the point on the specimen. A stage actuator assembly causes the specimen to move relative to the point in two dimensions. A controller forms a mid-infrared region image from the first intensity. The image can be based on reflected or transmitted light. The maximum size of the imaged area is determined by a scanning assembly that moves in a first direction relative to the stage, the stage moving in a direction orthogonal to the first direction. | 03-31-2016 |
20160091705 | Methods and apparatus for stretched light field microscope - The information budget of a light field microscope is increased by increasing the field of view and image circle diameter of the microscope, while keeping the ratio of overall magnification of the microscope to the numerical aperture of the microscope unchanged. Alternatively, the information budget is increased by increasing the field of view and image circle diameter of the microscope by a first factor, while increasing the ratio of overall magnification of the microscope to the numerical aperture of the microscope by a smaller, second factor. In some cases, an infinity-corrected light field microscope has an overall magnification that is greater than the nominal magnification of the objective lens. | 03-31-2016 |
20160091707 | MICROSCOPE SYSTEM FOR SURGERY - From a first image indicating an intensity distribution of radiation from a subject | 03-31-2016 |
20160097923 | DIGITAL MICROSCOPE HAVING A CLICK STOP - A digital microscope has a stationary stand body ( | 04-07-2016 |
20160100136 | DIGITAL MICROSCOPE HAVING A SPRING-MOUNTED PIVOTABLE UNIT - A digital microscope includes a stationary stand body ( | 04-07-2016 |
20160103311 | LIGHT OBSERVATION DEVICE, IMAGING DEVICE USED FOR SAME, AND LIGHT OBSERVATION METHOD - A light observation device has a light splitting optical system for splitting observation light of an observation object; an imaging lens for focusing split beams to form optical images thereof; an imaging device arranged at image formation positions of the two optical images and being capable of performing independent rolling readout in a pixel row group included in a region corresponding to the image formation position of one optical image and in a pixel row group included in a region corresponding to the image formation position of the other optical image; and a control unit for independently controlling the rolling readout in the one pixel row group and in the other pixel row group; the control unit performs control such that a direction of the rolling readout in the one pixel row group and a direction of the rolling readout in the other pixel row group are identical. | 04-14-2016 |
20160109693 | OPTICAL SCANNING SYSTEMS FOR IN SITU GENETIC ANALYSIS - Presented herein are systems and methods for performing sequencing, including fluorescence in situ sequencing. In one embodiment, a confocal time delay and integration (TDI) line scan imaging system may include various pinhole and/or slit aperture mechanisms in front of the image sensor. The system may also include structures with focusing strips on a substrate in contact with the tissue sample to be imaged. Alternatively, these strips may be cut into the tissue sample. The system may also include configurations and methods of placing a tissue sample inside a reaction chamber of a flow cell during the assembly of the flow cell and then performing chemistry operations on the tissue sample. The flow cells may use an open container for performing chemistry operations on the tissue sample. | 04-21-2016 |
20160116725 | MICROSCOPE MODULE AND MICROSCOPE DEVICE - A microscope module includes a light source assembly, a sampling assembly and a diffusing element. The light source assembly includes a light source and a light guide element. The light source is disposed close to the light incidence end of the light guide element. The sampling assembly includes a cover and a base. The cover and the base are combined to define a sample accommodating space, which is located at the light exit end of the light guide element. The diffusing element is disposed between the light source and the sample accommodating space. The light emitted from the light source passes through the diffusing element and then enters the sample accommodating space. A microscope device containing the microscope module is also disclosed. | 04-28-2016 |
20160116727 | MICROSCOPE APPARATUS AND STORAGE MEDIUM STORING MICROSCOPE APPARATUS CONTROL PROGRAM - A microscope apparatus includes a monitoring optical system, an imaging unit capturing an image of an observation target through the monitoring optical system to generate a plurality of images, a correction unit disposed in the optical monitoring system and correcting various aberrations which occur due to an observation condition, and a decision unit deciding a correction amount of the correction unit based on the plurality of images generated by the imaging unit, whereby an image deterioration ascribable to the aberration occurring due to the observation condition in the microscope apparatus is appropriately and easily corrected according to a use condition of the microscope apparatus. | 04-28-2016 |
20160116728 | LUMINESCENCE MICROSCOPY - The invention relates to a method for high-resolution luminescence microscopy of a specimen marked with marker molecules, and to a luminescence microscope for performing the method, wherein the marker molecules can be excited to emit luminescence radiation. The method for luminescence microscopy comprises the excitation and imaging of marker molecules and the transmission of a trigger time and a position of the specimen. An optical recording device images the marker molecules in a capture area and transmits data from the imaging to an image capture circuit. The recording device transmits a time for the imaging to a signal former as a trigger time; the trigger time is then transmitted to a data recorder. The data recorder generates a position of the specimen at the trigger time and transmits said position to the image capture circuit, which links the position of the specimen in the depth direction to the data of the imaging of a frame such that a three-dimensional tomographic image of the specimen can be created. | 04-28-2016 |
20160124130 | Spectral Target for Macroscopic and Microscopic Reflectance Imaging - A spectrally selective (e.g., color) target has been designed and fabricated for reflectance micro- and/or macro-imaging that utilizes microlens arrays and color mirrors. The color mirrors are optical interference coatings. The microlenses are designed and fabricated such that the light reflected from the color mirror is incident onto the detector. This system of microlenses and color mirrors allows the user to image different colored specular highlights. An infinite number of spectral reflectance profiles can be created with these color targets and used for spectral and colorimetric imaging applications. The targets are not limited to the visible region; they can also be designed to work in the ultraviolet and infrared wavelength regions. | 05-05-2016 |
20160124203 | MICROSCOPE AND MICROSCOPE IMAGE ACQUISITION METHOD - To prevent unwanted exposure of a specimen with excitation light despite magnification switching, a microscope of the present invention includes: a detection optical system that detects fluorescence emitted from the specimen; a light-sheet illumination optical system, serving as an excitation light source, that causes planar excitation light to be incident along a direction intersecting an optical axis of the detection optical system; and a control section that, when the magnification of the detection optical system is raised, controls the light-sheet illumination optical system so as to reduce a radiation width of the excitation light made incident on the specimen by the light-sheet illumination optical system. | 05-05-2016 |
20160124206 | POC-TEST SYSTEM WITH MOBILE COMPUTER UNIT AND METHOD - This invention relates to a test system along with test strips and a test process and its use, especially in the point of care (PoC) area, the test system comprising a mobile computing device having an image processing device arranged on an optical magnification device that is used to analyze body fluids. | 05-05-2016 |
20160125615 | FLOW ANALYZER, FLOW CYTOMETER AND FLOW ANALYZING METHOD - A flow analyzer includes a flash lamp configured to irradiate a flow cell having a flow path with flash light, the flow path having a predetermined width, an imaging section configured to take images of the flow cell that is irradiated by the flash lamp such that the predetermined width is included in an imaging range, an evaluator configured to detect edges indicating respective sides of the flow cell from an image of a fluid that is taken by the imaging section and to evaluate the fluid passing through the flow cell based on a relationship between a width between the detected edges and the predetermined width, and an output section configured to output a result of the evaluation by the evaluator. | 05-05-2016 |
20160127707 | COLOR CALIBRATION FOR PATHOLOGY SLIDES - A method and system for color calibration for digital microscopy includes obtaining an image of a stained sample and obtaining a desired stain type and density information. A synthesizing spectral absorption is determined based on the desired stain type and density, and a digital image is produced from the image of the stained sample based on a spectral absorption of the desired stain type, density, and a light source. The image is then outputted to a storage medium or display. The method also includes estimating a stain type used in the image of the stained sample, and estimating a density of the stained sample. | 05-05-2016 |
20160131880 | MEDICAL OBSERVATION APPARATUS, MEDICAL VIDEO MICROSCOPE APPARATUS, AND MEDICAL VIDEO MICROSCOPE SYSTEM - There is provided a medical observation apparatus including: a holding unit including a transmission mechanism including a plurality of joint units placed in positions different from each other and configured to rotate in conjunction with each other around a rotation axis in the same direction. Brakes are placed for at least two joint units of the plurality of joint units. | 05-12-2016 |
20160131883 | High-Resolution Scanning Microscopy - A microscope and method for high resolution scanning microscopy of a sample, having an illumination device, an imaging device for the purpose of scanning at least one point or linear spot across the sample and of imaging the point or linear spot into a diffraction-limited, static single image below a reproduction scale in a detection plane. A detector device is used for detecting the single image in the detection plane for various scan positions, with a location accuracy which, taking into account the reproduction scale in at least one dimension/measurement, is at least twice as high as a full width at half maximum of the diffraction-limited single image. | 05-12-2016 |
20160131887 | AUTOFOCUS ALGORITHM FOR MICROSCOPY SYSTEM BASED ON CROSS-CORRELATION - Optimized automatic focusing of a microscope objective based on a cross correlation between a representative focus metric scan and a focus metric scan of a sample to be imaged. | 05-12-2016 |
20160131891 | IMAGE PROCESSING METHOD, IMAGE PROCESSING APPARATUS, IMAGE PICKUP APPARATUS, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM - An image processing apparatus includes a first calculator configured to calculate combination coefficients through a linear combination of a basis generated from a plurality of first images that are obtained by photoelectrically converting optical images of a plurality of known first samples formed by a partially coherent or coherent imaging optical system, the combination coefficients being used to approximate a second image, a second calculator configured to calculate intermediate data based on a plurality of complex quantity data obtained by a non-linear mapping of data of the first samples and the combination coefficients calculated by the first calculator, and a third calculator configured to calculate complex quantity data of an unknown second sample based on the intermediate data calculated by the second calculator. | 05-12-2016 |
20160139387 | PREVIEW STATION AND METHOD FOR TAKING PREVIEW IMAGES OF MICROSCOPE SLIDES - A preview station for previewing microscope slides where each slide has one or more specimens thereon, the preview station having a tray holder supporting a slide tray with a plurality of slides thereon. A digital camera and lens is located on an optical axis relative to the slide tray and a light source illuminates the slide tray. The camera is activated to image each slide in the slide tray and has a memory to store and transmit data from each slide. The preview station can be used in combination with a scanning system and can be made part of a scanning system. | 05-19-2016 |
20160139388 | METHODS AND SYSTEMS FOR TRANSPORT-OF-INTENSITY IMAGING - A transport-of-intensity imaging system is proposed which incorporates a control element positioned in an optical relay system, such as a 4f optical relay system, between a microscope system for generating an image of a specimen, and an image capturing device. The control element is located with an optical relay system, and is controllable to vary the focal plane without changing the spacing of the specimen and the image capturing device. In one form the control element is an electronically tunable lens (ETL). In another form, the control element is a spatial light modulator (SLM). The arrangement may include a beam splitter arrangement for generating a plurality of beams, which are not all subject to the same control element, such that multiple images with different focal planes are captured from the respective beams. | 05-19-2016 |
20160139389 | MICROSCOPE SYSTEM - A microscope system includes a virtual-slide microscope that acquires a virtual-slide image of a specimen when mounted on a first stage, and a fluorescence microscope that acquires a fluorescence image of the specimen when mounted on a second stage. The virtual-slide microscope includes a display and an image-capturing-condition setting portion that sets image capturing conditions, including a fluorescence-image acquisition position, on the virtual-slide image. The fluorescence microscope includes a memory portion that stores coordinate transformation data between the coordinates of the specimen when fixed on the first stage and the coordinates of the specimen when fixed on the second stage, a condition input portion to which the image capturing conditions are input, and a driving-condition setting portion that sets a driving condition on the basis of the image capturing conditions and the coordinate transformation data. | 05-19-2016 |
20160139396 | OPTICAL APPARATUS - Provided is an optical apparatus including: a mounting section on which an object is mounted; an observation section including an imaging optical system that forms an image of the object mounted on the mounting section; a shaft section rotatable in a first direction and a second direction opposite to the first direction; a drive section that moves one of the observation section and the mounting section in a third direction that defies a gravity according to a rotation of the shaft section in the first direction and in a fourth direction opposite to the third direction according to a rotation of the shaft section in the second direction; and a torque control section including a clutch section that permits the rotation of the shaft section in the first direction, inhibits the rotation of the shaft section in the second direction, and rotates in the second direction with the shaft section as a rotation force in the second direction is input to the shaft section, and a restriction section that restricts the rotation of the clutch section. | 05-19-2016 |
20160147053 | IMAGE ACQUISITION DEVICE AND IMAGE ACQUISITION METHOD - This image acquisition device comprises: a specimen stage on which a specimen as a target of image acquisition is to be mounted; a micro-use light source having a light emitting device and a heat dissipator for dissipating heat generated by the light emitting device, and emitting light to the specimen; an objective arranged so as to be opposed to the specimen on the stage, as a light-guide optical system for guiding an optical image of the specimen; a micro image acquisition unit configured to capture the optical image of the specimen thus guided; and a micro-use light source controller configured to control the light emitting device so as to implement the emission of light by the micro-use light source, during a standby period between image acquisition periods of capturing optical images of a plurality of specimens. | 05-26-2016 |
20160147057 | LENS UNIT AND TRANSMISSION COMPOUND MICROSCOPE - An object of the invention is to provide a lens unit, an illumination cap member, a sample observation kit, and a transmission compound microscope that enable to easily acquire a microscopic observation image by being mounted on a smart device with a simplified structure. A lens unit | 05-26-2016 |
20160154229 | SPECTRALLY-ENCODED HIGH-EXTINCTION POLARIZATION MICROSCOPE AND METHODS OF USE | 06-02-2016 |
20160170196 | OPTICAL OBSERVATION APPARATUS AND METHOD FOR OPERATING AN OPTICAL OBSERVATION APPARATUS | 06-16-2016 |
20160170197 | CALIBRATION OF MICROSCOPY SYSTEMS | 06-16-2016 |
20160178882 | CONTROL SYSTEM FOR A MICROSCOPE AND METHOD FOR CONTROLLING A MICROSCOPE | 06-23-2016 |
20160187636 | Microscopy Blade System And Method Of Control - A microscopy system for monitoring of one or more specimens includes a plurality of microscope blades, each microscope blade having at least one objective, at least one illuminator, and at least one detector. The microscopy system also includes a plurality of carriages, each carriage being connected to one or more of the microscope blades, and one or more actuators configured to drive the plurality of carriages along one or more axes, at least some of the plurality of carriages having at least partially overlapping ranges of motion along at least one of the one or more axes. The microscopy system also includes a master controller configured to drive each of the carriages, using the actuator(s), along the one or more axes. | 06-30-2016 |
20160187637 | IMAGE PROCESSING APPARATUS, STORAGE MEDIUM, AND IMAGE PROCESSING METHOD - An image processing apparatus includes a detection-difficulty determination unit and a detection-parameter setting unit. The detection-difficulty determination unit calculates a degree of detection difficulty indicating a degree of difficulty in detection of a target cell contained in a specimen, based on a test object condition of the specimen. The detection-parameter setting unit sets a detection parameter for the detection of the target cell from a captured image of the specimen, based on the degree of detection difficulty. | 06-30-2016 |
20160187638 | IMAGING APPARATUS, MICROSCOPE SYSTEM, IMAGING METHOD, AND COMPUTER-READABLE RECORDING MEDIUM - An imaging method including: controlling luminance distribution of light such that the light continuously attenuates from an inner side toward an edge in a peripheral area within an imaging range of an imaging unit; emitting, in the imaging range, the light whose luminance distribution has been controlled; imaging an object within the imaging range where the light has been emitted to generate image data; sequentially moving the imaging range relative to the object such that peripheral areas where the light attenuates overlap with each other in adjacent imaging ranges; sequentially obtaining a plurality of images with different imaging ranges based on the image data; and creating a combined image by stitching the plurality of images in such a way that adjacent images of the plurality of images corresponding to the adjacent imaging ranges are stitched together such that image areas corresponding to the peripheral areas overlap with each other. | 06-30-2016 |
20160195704 | HIGH-RESOLUTION 3D FLUORESCENCE MICROSCOPY | 07-07-2016 |
20160195705 | MICROSCOPY WITH STRUCTURED PLANE ILLUMINATION AND POINT ACCUMULATION FOR IMAGING AND NANOSCALE TOPOGRAPHY | 07-07-2016 |
20160202460 | 3D Microscopy With Illumination Engineering | 07-14-2016 |
20160252716 | PROJECTION SYSTEM | 09-01-2016 |
20160252717 | IMAGE ACQUISITION DEVICE AND IMAGE ACQUISITION METHOD FOR IMAGE ACQUISITION DEVICE | 09-01-2016 |
20160253572 | METHOD FOR DETECTING MICROORGANISM HAVING FLUORESCENT CHARACTERISTICS WITH RESPECT TO SPECIFIC WAVELENGTH | 09-01-2016 |
20170235087 | SOLID IMMERSION LENS HOLDER AND IMAGE ACQUISITION DEVICE | 08-17-2017 |
20170235119 | CONFOCAL MICROSCOPE APPARATUS, STITCHED IMAGE CONSTRUCTION METHOD AND COMPUTER-READABLE MEDIUM | 08-17-2017 |
20170237894 | APPARATUS FOR AND METHOD OF OBSERVING CELLS | 08-17-2017 |
20180024339 | MAGNIFYING OBSERVATION APPARATUS | 01-25-2018 |
20180024340 | MAGNIFYING OBSERVATION APPARATUS | 01-25-2018 |
20180024346 | MAGNIFYING OBSERVATION APPARATUS | 01-25-2018 |
20180027173 | Fast Auto-Focus in Imaging | 01-25-2018 |
20190146204 | Angularly-Selective Illumination | 05-16-2019 |
20220137382 | LIGHT SHEET MICROSCOPE AND METHOD FOR LIGHT SHEET MICROSCOPY - In a light sheet microscope, a detection device images a sample volume and an illumination device illuminates the sample with a light sheet. A light sheet plane is arranged substantially perpendicularly to the optical imaging axis and an illumination width extends perpendicular to the light sheet plane. A processing device is provided to control setting of the location of the light sheet plane in the sample volume, and recording a plurality of images of the sample volume with different locations of the light sheet plane. For the plurality of images recorded, a spacing, which is measured along the optical imaging axis, between adjacent locations of the light sheet plane is greater than or equal to half the illumination width, but not greater than the illumination width. Intermediate images for the stack of images in additional locations of the light sheet plane in the sample volume are computed. | 05-05-2022 |
20220138939 | Systems and Methods for Digital Pathology - Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease. | 05-05-2022 |