Class / Patent application number | Description | Number of patent applications / Date published |
250290000 | Cyclically varying ion selecting field means | 85 |
20080251717 | Q-pole type mass spectrometer - A Q-pole type mass spectrometer can be used under a high-pressure atmosphere of more than 0.1 Pa. The Q-pole type mass spectrometer can analyze the mass of gas molecules continuously, and can separate mass properly even if an ion is injected at high speed in order to reduce the influence of an end electric field near an end face (fringing) of the Q-pole. The motion of the ions to be measured in the diameter direction is independent of the motion of ions in the axial direction within the Q-pole region of the Q-pole type mass spectrometer. In the Q-pole type mass spectrometer installed in a reduced pressure atmosphere, the motion of ions to be measured in the axial direction advancing from an ion source toward a collector, is controlled within the Q-pole region so as to separate the mass of the ions to be measured by Coulomb force generated by a quadrupole high-frequency electric field in the diameter direction. | 10-16-2008 |
20080315085 | FAIMS Cell Having an Offset Ion Inlet Orifice - A FAIMS cell has an elongated inner electrode with a longitudinal axis extending along a first direction. The inner electrode has a curved outer surface that defines a circle when viewed in a cross section that is taken in a plane normal to the longitudinal axis, which itself passes through the center of the circle so defined. An outer electrode having an inner surface is disposed in a spaced-apart facing relationship relative to the outer surface of the inner electrode so as to define an analytical gap therebetween. A first ion inlet orifice is defined through a first portion of the outer electrode, and an ion outlet orifice is defined through a second portion of the outer electrode. In particular, the first ion inlet orifice has a first ion injection axis that does not pass through the center of the circle. Furthermore, the second electrode does not have defined through any portion thereof an ion inlet orifice having an ion injection axis that passes through the center of the circle. | 12-25-2008 |
20080315086 | BRANCHED RADIO FREQUENCY MULTIPOLE - Systems and methods of the invention include a branched radio frequency multipole configured to act, for example, as an ion guide. The branched radio frequency multipole comprises multiple ion channels through which ions can be alternatively directed. The branched radio frequency multipole is configured to control which of the multiple ion channels ions are directed, through the application of appropriate potentials. | 12-25-2008 |
20090065692 | High pressure collision cell for mass spectrometer - A high pressure collision cell for use in a mass spectrometer. The high pressure collision cell has a cell length L selected to be in a range such that upon application of voltages to a pair of opposed elongate electrically conducting electrodes there is produced an electric field of sufficient strength across the collision cell length L in to aid in directing ions entering the collision cell to along a transverse flow axis. The pressure in the collision cell is maintained in a range from about 50 mTorr to 1000 mTorr and wherein the collision cell length L and the pressure are selected such that a target thickness, defined as a product of the collision cell length L and the pressure, is maintained in a range from about 0.2 to about 2 mm-Torr. | 03-12-2009 |
20090072136 | Mass Spectrometer - A mass analyser ( | 03-19-2009 |
20090127456 | RF Power Supply for a Mass Spectrometer - The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output. | 05-21-2009 |
20090206250 | PARALLEL PLATE ELECTRODE ARRANGEMENT APPARATUS AND METHOD - A system for guiding an ion beam along an axis (Z), comprises at least one section having upper flat plate strip electrodes (Iu, | 08-20-2009 |
20090261246 | Compact superconducting magnet configuration with active shielding having a shielding coil contributing to field formation - A superconducting magnet configuration ( | 10-22-2009 |
20090272898 | Two-Dimensional Ion Trap with Ramped Axial Potentials - The invention provides a two-dimensional ion trap, comprising a plurality of elongate electrodes positioned between first and second end electrodes, the plurality of electrodes and first and second end electrodes defining a trapping volume. A controller in electrical communication with the plurality of elongate electrodes and the first and second end electrodes is configured to progressively vary a periodic voltage applied to at least one of the plurality of elongate electrodes to cause ions to be radially ejected from the ion trap in order of their mass to charge ratios. Concurrently, the controller is configured to progressively vary a DC offset of least one of the first and second end electrodes with respect to the plurality of elongate electrodes. | 11-05-2009 |
20090278043 | ION GUIDE DEVICE, ION REACTOR, AND MASS ANALYZER - A charged particle reaction cell of the present invention has a serially-arranged plurality of ring electrodes, wherein a modulated radio frequency voltage obtained by modulating the amplitude of a radio frequency voltage is applied, whereby ions are captured at the bottom of the ups and downs of a formed pseudopotential and are transferred with the move of the pseudopotential. In the charged particle reaction cell, the time required for the charged particle reaction can be secured and also the problem of the decrease of the throughput or the mass resolution can be solved, and the speed of the structure analysis of a measurement sample can be accelerated. | 11-12-2009 |
20090294661 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - The present invention relates to an ion trap with a large trap capacity. A mass spectrometer comprises a first linear ion trap that performs mass selective ejection, and a second linear ion trap that accumulates and then mass selectively ejects ions ejected from the first linear ion trap. Directions of resonant excitation of ions of the first linear ion trap and of the second linear ion trap are orthogonal. Compared to conventional art, sensitivity is significantly improved. | 12-03-2009 |
20100301210 | CONVERGING MULTIPOLE ION GUIDE FOR ION BEAM SHAPING - A multipole ion guide comprises rods disposed about an axis, each of the rods having a first end and a second end remote from the first end. Each of the rods is disposed at a respective greater distance from the axis at the first end than at the second end. The multipole ion guide comprises means for applying a radio frequency (RF) voltage between adjacent pairs of rods, wherein the RF voltage creates a multipole field in a region between the rods; and means for applying a direct current (DC) voltage drop along a length of each of the rods. A mass spectroscopy system is also disclosed. | 12-02-2010 |
20110049360 | Collision/Reaction Cell for a Mass Spectrometer - A collision/reaction cell for a mass spectrometer includes an RF multipole having electrodes that are shaped and positioned such that the value of the radial spacing r | 03-03-2011 |
20110073756 | Quadrupole Mass Spectrometer - In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution. | 03-31-2011 |
20110084206 | Compact superconducting magnet configuration with active shielding having a shielding coil contributing to field formation - A superconducting magnet configuration ( | 04-14-2011 |
20110101220 | High Performance Micro-Fabricated Quadrupole Lens - This invention provides a method of aligning sets of cylindrical electrodes in the geometry of a miniature quadrupole electrostatic lens, which can act as a mass filter in a quadrupole mass spectrometer. The electrodes are mounted in pairs on microfabricated supports, which are formed from conducting parts on an insulating substrate. Complete segmentation of the conducting parts provides low capacitative coupling between co-planar cylindrical electrodes, and allows incorporation of a Brubaker prefilter to improve sensitivity at a given mass resolution. A complete quadrupole is constructed from two such supports, which are spaced apart by further conducting spacers. The spacers are continued around the electrodes to provide a conducting screen. | 05-05-2011 |
20110186733 | Two-Dimensional Radial-Ejection Ion Trap Operable as a Quadrupole Mass Filter - A two-dimensional radial-ejection ion trap is constructed from four apertured electrodes having inwardly facing hyperbolic surfaces, with each electrode being spaced from the centerline by a distance r that is greater than the hyperbolic radius r | 08-04-2011 |
20110278450 | ION GUIDES AND COLLISION CELLS - In an embodiment, a collision cell comprises rods each having a first end and a second end remote from the first end; an inductor connected between adjacent pairs of rods; and means for applying a radio frequency (RF) voltage between adjacent pairs of rods. The RF voltage creates a multipole field in a region between the rods; and means for applying a direct current (DC) voltage drop along a length of each of the rods. | 11-17-2011 |
20120119083 | Ion Trap Device - Ions supplied in the form of a pulse are introduced into an ion trap through an ion entering orifice while a rectangular voltage of a frequency higher than the frequency at which the best trap is accomplished is applied to a ring electrode from a trap voltage generating unit. With this, since a well of a pseudo ion potential is formed in a radial direction in the ion trap, the spread of ions of low m/z values introduced previously is suppressed. A part of ions is introduced into the ion trap, and thereafter the frequency of the rectangular voltage applied to the ring electrode is lowered stepwise to the frequency at which the best trap is accomplished. As a result, the ions of the low m/z values introduced previously can be efficiently trapped, and introduction of ions of high m/z values reaching the ion trap later is not hindered. Consequently, ions of a wide range of m/z values can be trapped in the ion trap with high efficiency | 05-17-2012 |
20120267526 | Mass Spectrometer - An ion trap mass analyser is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyser by a radial pseudo-potential well. The ions are also confined axially within a quadratic axial potential well. An AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser in order to excite parametrically ions within the ion trap. | 10-25-2012 |
20120280123 | Ion Tunnel Ion Guide - An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments. | 11-08-2012 |
20130200261 | Quadrupole Mass Spectrometer - As a control parameter given to a direct-current (DC) voltage generator which generates a DC voltage for ion selection, a “mass-related offset” for allowing an adjustment of the offset for each mass-to-charge ratio is provided in addition to the “gain” and “common offset” which respectively determine the gradient and position of a scan line drawn on a stability diagram during a mass-scan operation. In an automatic adjustment operation using a standard sample, under the control of an automatic regulator, the “gain” and “common offset” are initially set, after which the “mass-related offset” for each mass-to-charge ratio is determined so that the mass-resolving power will be substantially uniform, and these data are stored in a control data memory. In an analysis of a sample of interest, a quadrupole voltage controller controls the DC voltage generator and a radio-frequency (RF) voltage generator according to the control parameters read from the memory. | 08-08-2013 |
20130264475 | SELECTIVE IONIZATION USING HIGH FREQUENCY FILTERING OF REACTIVE IONS - Selective ionization at atmospheric or near atmospheric pressure of a sample diluted in air is provided in multiple steps. Initially, components of air and/or other gas are ionized to generate reactive ions. The reactive ions are then filtered using a high frequency filter to yield selected reactive ions. Thereafter, the selected reactive ions are reacted with sample molecules of a sample being analyzed in a charge transfer process. Depending on the properties of the sample molecules, the filter may select some reactive ions to enter the sample zone and block others entirely thus controlling ion chemistry and charge transfer yields in the sample zone. The described system is directed to controlling ions at the ion source level, using a high frequency filter technique, in connection with subsequent analysis. The method generates the ions of choice for subsequent analysis in such platforms as ion mobility and differential mobility spectrometers. | 10-10-2013 |
20130299695 | Microengineered multipole ion guide - A microengineered multipole ion guide for use in miniature mass spectrometer systems is described. Exemplary methods of mounting rods in hexapole, octupole, and other multipole geometries are described. The rods forming the ion guide are supported by etched silicon structures provided on first and second substrates. | 11-14-2013 |
20130306861 | ION GUIDE WITH DIFFERENT ORDER MULTIPOLAR FIELD ORDER DISTRIBUTIONS ACROSS LIKE SEGMENTS - The present disclosure relates to mass spectrometers and, in particular, multipole ion guides and control units that set the RF and DC potentials at the ion guide to, among other uses, radially confine an ion beam. In an exemplary embodiment, the ion guide includes a plurality of circumferentially arranged elongated rods disposed about a common axis that form a plurality of longitudinally traversing segments. At least a first and a second subset of the segments have an equal number of elongated rods and are physically configured to receive a first and a second set of EMF from a control unit that results in a first multipolar field order distribution and a second multipolar field distribution, respectively, being produced that are different from one another. | 11-21-2013 |
20130313427 | QUADRUPOLE MASS SPECTROMETER - A quadrupole power source which applies a voltage to each electrode ( | 11-28-2013 |
20140042315 | COMPACT ION MOBILITY SPECTROMETER - The invention relates to devices for measuring the mobility of ions in gases at pressures of a few hectopascal. To make the device more compact, drift regions are bent into curved shapes, which extend into the third dimension. Parts of the drift region may lie above others. Alternating directions of curvature in the curved shapes balance out different path lengths by passing through approximately equal drift distances on outer and inner trajectories. Ions are held near the axis of the curved drift region by sectional or permanent focusing. One possible shape is a double loop in the shape of a figure eight. The shape extends perpendicular to its plane of projection so that several double loops lie on top of each other. RF ion funnels or ion tunnels can keep the ions near the axis. Axial focusing may use a pseudopotential radial to the axis of the curved shape. | 02-13-2014 |
20140054457 | MASS SPECTROMETER WITH RIGID CONNECTION ASSEMBLIES - In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized. | 02-27-2014 |
20140084156 | RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS AT HIGH PRESSURE - Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system. | 03-27-2014 |
20140124663 | Ion Mobility Separator With Variable Effective Length - An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator. | 05-08-2014 |
20140145076 | APPARATUS AND METHOD FOR CROSS-FLOW ION MOBILITY SPECTROMETRY - A cross-flow ion mobility spectrometer consists of two parallel plates defining a volume between them. Analyte ions flow along an axis from an entrance end to an exit end through the volume. An RF confining field tends to guide ions along the axis. An analytical gas flow is established orthogonal to the axis. A DC electrostatic analytical field is oriented in opposition to the analytical gas flow such that the “drag force” on ions of the selected mobility due to the analytical gas flow is balanced by the force on the ions due to the electrostatic analytical field. The selected ions are thereby able to follow a stable path to the exit end of the cross-flow mobility analyzer. However, the force on ions of other than the selected mobility is unbalanced and these ions are deflected and lost. | 05-29-2014 |
20140183355 | HIGH PRESSURE MASS SPECTROMETRY SYSTEMS AND METHODS - Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed. | 07-03-2014 |
20140246582 | MULTI-POLE ION TRAP FOR MASS SPECTROMETRY - An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis. | 09-04-2014 |
20140299766 | ION MANIPULATION DEVICE - An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. | 10-09-2014 |
20150041642 | MASS SPECTROGRAPH APPARATUS AND METHOD OF DRIVING ION GUIDE - In eight electrodes arranged at an interval of a rotational angle of 45° around an ion optical axis, two neighboring electrodes are electrically connected together as one group, and electrodes in alternate groups are also electrically connected together. A voltage V | 02-12-2015 |
20150076343 | ION MANIPULATION DEVICE TO PREVENT LOSS OF IONS - An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase. | 03-19-2015 |
20150102219 | TANDEM QUADRUPOLE MASS SPECTROMETER - Prior to multiple reaction monitoring (MRM) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen | 04-16-2015 |
20150108348 | MASS SPECTROMETER - The larger an m/z to be adjusted, the wider a peak width which represents change in intensity in relation to change in voltage. This allows voltage step size to be increased during a search for an optimum voltage without overlooking a maximum intensity. Thus, a relational expression which gives a narrow voltage step size for a low m/z and gives a wide voltage step size for a high m/z is prestored in a voltage step information storage unit ( | 04-23-2015 |
20150144784 | Exponential Scan Mode for Quadrupole Mass Spectrometers to Generate Super-Resolved Mass Spectra - A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the RF and DC voltages on a quadrupole mass filter versus time while maintaining the RF and DC in constant proportion to each other. In such a novel mode of operation, ion intensity as a function of time is the convolution of a fixed peak shape response with the underlying (unknown) distribution of discrete mass-to-charge ratios (mass spectrum). As a result, the mass distribution can be reconstructed by deconvolution, producing a mass spectrum with enhanced sensitivity and mass resolving power. | 05-28-2015 |
20150303044 | Miniaturized Ion Mobility Spectrometer - By utilizing the combination of a unique electronic ion injection control circuit in conjunction with a particularly designed drift cell construction, the instantly disclosed ion mobility spectrometer achieves increased levels of sensitivity, while achieving significant reductions in size and weight. The instant IMS is of a much simpler and easy to manufacture design, rugged and hermetically sealed, capable of operation at high temperatures to at least 250° C., and is uniquely sensitive, particularly to explosive chemicals. | 10-22-2015 |
20160054265 | ENVIRONMENT DETECTING APPARATUS EMPLOYING AN ASYMMETRIC WAVEFORM PULSE GENERATOR - An environment detecting apparatus employing an asymmetric waveform pulse generator is disclosed. The asymmetric waveform pulse generator comprises a metal oxide semiconductor field effect transistor (MOSFET) bridge circuit that comprises a plurality of MOSFETs for inverting high voltage DC voltage to asymmetric waveform pulses, a pulse-width modulating (PWM) circuit for generating PWM signals, and a plurality of isolation driving circuits corresponding to the plurality of MOSFETs, for controlling switching on/off of the plurality of MOSFETs in the MOSFET bridge circuit based on the PWM signals generated by the PWM circuit. Wherein each of the isolation driving circuits comprises an isolation transformer for isolating the MOSFET bridge circuit from the PWM circuit. | 02-25-2016 |
20160099137 | MASS SPECTROMETRY BY DETECTING POSITIVELY AND NEGATIVELY CHARGED PARTICLES - The disclosure features mass spectrometry systems and methods that include an ion source, an ion trap, a detector subsystem featuring first and second detector elements, and a controller electrically connected to the ion source, the ion trap, and the detector subsystem and configured so that during operation of the system, the controller: applies an electrical signal to the ion source to generate positively and negatively charged particles from sample particles in the system; applies an electrical signal to the ion trap to eject a plurality of particles from the ion trap through a common aperture of the ion trap, and determines information about the sample particles based on first and second electrical signals generated by the ejected particles. | 04-07-2016 |
20160118235 | MASS SPECTROMETER - In a pause time assigned for switching voltage applied to a quadrupole mass filter or other ion transport optical system so as to switch the mass-to-charge ratio of a target ion in an SIM measurement, the polarity of direct-current voltage applied to a pre-quadrupole mass filter is temporarily reversed. The voltage polarity reversal time is changed according to length of the pause time so that the ion intensity can sufficiently rise by the time the next dwell time begins. When the polarity of the voltage applied to the pre-quadrupole mass filter is reversed, the electric charges which lie on an insulating film of contaminants or other substances attached to the surface of the pre-quadrupole mass filter or on an insulating support structure are dispersed, whereby the charge-up is eliminated. Since ions are prevented from passing through, charge-up of a main quadrupole mass filter in the subsequent stage is also reduced. | 04-28-2016 |
250291000 | Circular ion path | 5 |
20080210862 | MASS SPECTROMETER - A mass spectrometer is provided in which ions are favorably introduced into a loop orbit or favorably led out from the loop orbit without affecting the motion of the ions flying along the loop orbit. An ion-introduction orbit | 09-04-2008 |
20090008549 | Tandem Fourier Transform Ion Cyclotron Resonance Mass Spectrometer - A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell | 01-08-2009 |
20090166533 | FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER USING A CRYO-DETECTION SYSTEM - A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is provided. A preamplifier is installed as nearest to an ion cyclotron resonance (ICR) trap as possible at a detector part in the mass spectrometer, and thermal noise generated at the preamplifier is minimized by means of a cryo-cooling system to increase a signal-to-noise ratio of ion detection signals such that an ultra-low amount of specimen can be detected, which was impossible in the related art. | 07-02-2009 |
20090294662 | Ion funnel ion trap and process - An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 μs, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes. | 12-03-2009 |
20150380227 | TWO ROTATING ELECTRIC FIELDS MASS ANALYZER - A mass analyzer includes two rotating electric field (REF) units, sinusoidal signal generators and a means for separation of dispersed ions. The REF units include a plurality of elongated electrodes surrounding a central axis, and are lined in tandem at elongated direction. Sinusoidal signals are applied to the electrodes to rotate electric fields within each REF unit. The means for separation is placed adjacent the downstream end of the 2 | 12-31-2015 |
250292000 | Laterally resonant ion path | 34 |
20080203294 | System and Method for Implementing Balanced RF Fields in an Ion Trap Device - A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential created by a compensation feature that minimizes non-linear field components created by one or more ejection slots in the ion trap. The ion trap includes a centerline that passes longitudinally through a trapping volume inside of the ion trap, a pair of Y electrodes with inner Y electrode surfaces that are approximately parallel to the centerline, and a pair of X electrodes with inner X electrode surfaces that are approximately parallel to the centerline. The X electrodes have ejection slots through which trapped ions are ejected from the ion trap. A Y signal with a Y signal amplitude is coupled to both of the Y electrodes. An X signal with an X signal amplitude is coupled to both of the X electrodes. The X signal amplitude is selected to be greater than the Y signal amplitude to thereby create a balanced centerline potential at the centerline of the ion trap device. | 08-28-2008 |
20080265155 | Separation and axial ejection of ions based on m/z ratio - A mass spectrometer includes a multipole having a main RF field for radially containing ions generally on a central axis. The multipole has first and second axial DC fields in opposite first and second direction along a length of the multipole. The first and second axial DC fields approach or add substantially to zero on the central axis. The multipole has an excitation voltage applied thereto for selectively exciting the ions of desired m/z ratios off the central axis. The excitation voltage thus causes excursion of the ions into a region where either the first or second axial DC field is strong. Thus, excitation of the ions and the DC fields cause ion drift toward a front end or a back end of the multipole. Further excitation moves the ions into regions of the DC fields that overcome barriers and causes axial ejection of the ions from the multipole. | 10-30-2008 |
20080272295 | MULTIPOLE MASS FILTER HAVING IMPROVED MASS RESOLUTION - A multipole mass filter having improved mass resolution. The multipole mass filer having a first electrode set coupled to at least a RF voltage source and a second electrode set interposed and parallel to the first electrode set. The second electrode set having a variable AC voltage coupled to two radially opposing electrodes of the second electrode set. | 11-06-2008 |
20080277580 | ION TRAP MASS SPECTROMETER - The number of times of repetition of mass spectrometry analysis for integrating mass profiles is reduced to facilitate reduction in measurement time-period and increase a signal intensity. In a state when ions are trapped by a high-frequency electric field formed within an ion trap, a rectangular-wave high-frequency voltage to be applied from a main voltage generation section to a ring electrode is temporarily stopped, and next ions are introduced from an ion entrance port into the ion trap in a state when only a static electric field exists within the ion trap. The high-frequency voltage application is re-started while at least a part of previously-trapped ions remain within the ion trap, to trap the newly-introduced ions in addition to the previous ions so as to increase an amount of ions to be accumulated, and the accumulated ions are subjected to the mass spectrometry analysis. | 11-13-2008 |
20080296494 | Ion Trap with longitudinal Permanent Magnet and Mass Spectrometer Using Same - The invention concerns a vacuum magnetic ion trap comprising an assembly forming a permanent magnet including at least two magnetized structures ( | 12-04-2008 |
20080296495 | RF Surfaces and RF Ion Guides - Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides Potential wells are formed near RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated over time in such wells During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage. | 12-04-2008 |
20080315087 | Method and apparatus for digital differential ion mobility separation - A method for differential mobility separation of ions using digital-drive based high voltage fast switching electronics. The digital waveform delivered to the spectrometer is characterized by at least two substantially rectangular pulses of different amplitude and polarity. The control circuitry allows for waveform frequency, duty cycle and pulse amplitudes to be varied independently. Balanced as well as unbalanced asymmetric waveforms can be designed for optimum differential mobility separation of ions. The digital drive is designed for differential mobility spectrometers including parallel plate and segmented plate multipoles of planar symmetry, as well as multipoles of cylindrical symmetry, which may optionally be arranged in series. The use of the digital drive establishes alternating electric fields during which the displacement as a result of ion oscillation is determined by mobility coefficients. | 12-25-2008 |
20090014645 | CONFINING IONS WITH FAST-OSCILLATING ELECTRIC FIELDS - The applicants' teachings provide methods, systems, and apparatus useful in operating mass spectrometers and other devices incorporating multipole rod sets or other multi-electrode devices to simultaneously contain ions of both positive and negative charges through the simultaneous application to the rods or other electrodes of both radio-frequency (RF) and alternating (AC) currents. | 01-15-2009 |
20090026367 | BATCH FABRICATED RECTANGULAR ROD, PLANAR MEMS QUADRUPOLE WITH ION OPTICS - A quadrupole mass filter (QMF) is provided. The QMF includes a plurality of rectangular shaped electrodes aligned in a symmetric manner to generate a quadrupole field. An aperture region is positioned in a center region parallel to and adjacent to each of the rectangular shaped electrodes. An incoming ion stream enters the aperture region so as to be controlled by the quadrupole field. | 01-29-2009 |
20090057553 | METHOD AND APPARATUS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY - A novel method and apparatus for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS). The FTICR-MS apparatus has a pre-ICR mass separation and filtering device capable of receiving ionized molecules with a plurality of mass to charge (M/Z) sub-ranges. The pre-ICR mass separation and filtering device divides the ionized molecules into a plurality of smaller packets, each of the smaller packets is within one of the M/Z sub-ranges. A magnet in the FTICR-MS apparatus provides a controlled magnetic field. A plurality of ion cyclotron resonance (ICR) cells are arranged in series in the controlled magnetic field and operate independently. An ion trapping device connects the pre-ICR mass separation and filtering device, and stores one of the plurality of smaller packets, prior to sending it to one of the plurality of ICR cells. | 03-05-2009 |
20090127457 | APPARATUS AND METHOD FOR AN ELECTRO-ACOUSTIC ION TRANSMITTOR - A method of transmitting ions along an analyzer region between closely spaced electrodes is disclosed. The method includes providing an analyzer region for transmitting ions, the analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a pressure within at least one portion of the analyzer region, to differ from the pressure within another part of the analyzer region, and providing an electric field that is synchronized with the pressure differences to focus the ions. | 05-21-2009 |
20090140141 | Method and Apparatus for Trapping Ions - An ion trap comprising elongate rods, electrodes, a first circuit, and a second circuit. The rods are for defining the radial extent of a trapping volume. The first circuit is connected to the rods for applying thereto a first RF signal that generates adjacent the trapping volume a radial RF containment field that radially contains ions of different polarities within the trapping volume. The electrodes define the axial extent of the trapping volume. The second circuit is connected to the electrodes for applying thereto a second RF signal that generates adjacent the trapping volume an axial RF containment field that axially contains the ions of different polarities within the trapping volume. The axial RF containment field is independent of the radial RF containment field. | 06-04-2009 |
20090166534 | METHOD AND APPARATUS FOR REDUCING SPACE CHARGE IN AN ION TRAP - Ion trap apparatus and methods for efficiently addressing the effects of charge space caused by ion trap overfilling, useful in linear ion traps of mass spectrometers. | 07-02-2009 |
20090173880 | Mass Spectrometer - An ion guide ( | 07-09-2009 |
20090194688 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device ( | 08-06-2009 |
20090261247 | Linear Ion Trap with Four Planar Electrodes - A rectilinear ion trap includes a first pair of spaced planar RF electrodes, mounted in parallel and a second pair of spaced planar electrodes, mounted in parallel and orthogonal to the first pair of electrodes. The configuration of the pairs of electrodes define an axial direction and a radial direction. The trap further includes an RF source that applies an RF voltage to at least one of the pairs of RF electrodes to generate RF fields to trap ions in the axial and radial directions. | 10-22-2009 |
20090294663 | CURVED ION GUIDE AND RELATED METHODS - An ion guide includes a plurality of curved electrodes and an ion deflecting device. The electrodes are arranged in parallel with each other and with a central curved axis, the curved central axis being co-extensive with an arc of a circular section having a radius of curvature, each electrode being radially spaced from the curved central axis, wherein the plurality of electrodes define a curved ion guide region arranged about the curved central axis and between opposing pairs of the electrodes. The ion deflecting device may include a device for applying a DC electric field to two or more of the electrodes in a radial direction. The ion deflecting device may include a pair of curved, parallel ion deflecting electrodes, which are in addition to curved electrodes utilized for applying an RF ion guiding field. | 12-03-2009 |
20100012836 | QUADRUPOLE MASS SPECTROMETER - The direct current bias voltage to be applied to the pre-filter | 01-21-2010 |
20100116982 | ION TRAP MASS SPECTROMETER - While applying a square wave voltage to the ion electrode ( | 05-13-2010 |
20100176295 | INTERLACED Y MULTIPOLE - A method and apparatus of combining two independent multipoles in an interlaced fashion to form a resultant multipole structure is introduced. Such an arrangement enables ions from two separate sources to be merged along a predetermined longitudinal direction but also enables in the reverse path, predetermined portions of ions from a single source to be directed along one or more ion channel paths to also enable, for example, simultaneous collection by a Time of Flight (TOF) mass analyzer and an ion trap. | 07-15-2010 |
20100193684 | QUADRUPOLE MASS SPECTROMETER | 08-05-2010 |
20100276591 | Electrode Structures - This invention describes an electrode structure formed from a plurality of individual electrodes, the individual electrodes being provided on separate submounts, the submounts being coupled to one another using kinematic ball mounts. Such a structure may be configured as a RF ion guide, mass filter or ion trap. | 11-04-2010 |
20100308218 | MULTIPOLE ION TRANSPORT APPARATUS AND RELATED METHODS - An ion transport apparatus includes an ion entrance end, an ion exit end, and electrodes arranged along a longitudinal axis from the ion entrance end toward the ion exit end. The electrodes are configured for applying an RF electrical field that varies along the longitudinal axis such that at the ion entrance end, the RF electrical field comprises a major first multipole component of 2n | 12-09-2010 |
20110101221 | Quadrupole Mass Spectrometer - In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution. | 05-05-2011 |
20110121175 | Mass Spectrometer - The present invention aims at enhancing the ion transport efficiency in an ion guide for transporting ions into the subsequent stage while converging the ions by using a collisional cooling method and a radio-frequency electric field. In the present invention, a transport region through which ions pass is divided into an anterior region # | 05-26-2011 |
20110147584 | ION GUIDE FOR MASS SPECTROMETERS - The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region. | 06-23-2011 |
20110284741 | MIXED RADIO FREQUENCY MULTIPOLE ROD SYSTEM AS ION REACTOR - The invention relates to a linear multipole ion storage device which is suitable for reactions between positive and negative ions, and for fragmentation reactions by electron transfer dissociation (ETD) in particular. The invention uses a linear RF ion trap with at least three pairs of rods with a new type of electronic power supply. The two phases of a first RF voltage are applied to the pole rods alternately around the circumference and confine positive as well as negative ions in the radial direction. A second RF voltage is either applied single-phase to some of the pole rods, but not to all of them, or two-phase to unequal numbers of pole rods so that the axis potential oscillates with the frequency of this second RF voltage and generates a pseudopotential barrier which acts axially on ions of both polarities at the ends of the ion storage device. In the interior, the second RF produces a complex superposition field resulting in an increased fragmentation yield for ETD. | 11-24-2011 |
20130026360 | LATERAL INTRODUCTION OF IONS INTO RF ION GUIDES - An ion guide system includes an ion guide with pole rods, a device for laterally introducing ion species, and a mass spectrometer for analyzing product ions of reactions between different ion species. The device is configured and positioned such that an RF field with at least two-fold rotational symmetry with respect to the axis is generated. The device includes shortened pole rods and/or further electrodes. The pole rods and the further electrodes have at least two-fold rotational symmetry. The symmetry of the RF field allows ions to travel straight ahead through the ion guide with no hindrance. Such arrangements are particularly suitable for bringing together largely loss-free positive and negative ion species for reacting them. The reactions may be used to fragment multiply charged biopolymer ions by electron transfer or to remove excess charges of multiply charged biopolymer ions. | 01-31-2013 |
20130187044 | A WIRE ELECTRODE BASED ION GUIDE DEVICE - This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis. | 07-25-2013 |
20160027633 | Collision Cell Multipole - Mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion. A low-mass cut-off of the multipole may be controlled by varying a q value from a first to at least a second value. The multipole may have multipole electrodes disposed about a central axis and having a respective first portion, second portion, and intermediate portion therebetween which is radially closer to the central axis. This offers relatively high acceptance and ion transmission, while providing low-mass cut-off for removing undesired/interfering ions and helping reduce background count. | 01-28-2016 |
20160042934 | LATERAL INTRODUCTION OF IONS INTO RF ION GUIDES - An ion guide system includes an ion guide with pole rods, a device for laterally introducing an ion species, and a mass spectrometer for analyzing product ions of reactions between different ion species. The device is configured and positioned such that an RF field with at least two-fold rotational symmetry with respect to the axis is generated. The device includes shortened pole rods and/or further electrodes. The pole rods and the further electrodes have at least two-fold rotational symmetry. The symmetry of the RF field allows ions to travel straight ahead through the ion guide with no hindrance. Such arrangements are particularly suitable for bringing together largely loss-free positive and negative ion species for reacting them. The reactions may be used to fragment multiply charged biopolymer ions by electron transfer or to remove excess charges of multiply charged biopolymer ions. | 02-11-2016 |
20160133452 | DUAL FIELD MULTIPOLE CONVERGING ION GUIDES, HYPERBOLIC ION GUIDES, AND RELATED METHODS - An ion guide generates a first RF field of Nth order where N is an integer equal to or greater than 2, and a second RF field of 2Nth order superimposed on the first RF field. The first and second RF fields may be generated by respective first and second sets of electrodes. Another ion guide may include a converging entrance section followed by an exit section. The converging section may have a hyperbolic profile. A hyperbolic profile may be presented by electrodes having a twisted configuration relative to an ion guide axis. | 05-12-2016 |
20160141168 | MINIATURE CHARGED PARTICLE TRAP WITH ELONGATED TRAPPING REGION FOR MASS SPECTROMETRY - A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. | 05-19-2016 |
20160181080 | MULTIPOLE ION GUIDES UTILIZING SEGMENTED AND HELICAL ELECTRODES, AND RELATED SYSTEMS AND METHODS | 06-23-2016 |
250293000 | Alternating field ion selecting means | 3 |
20120248307 | Linear Ion Trap Analyzer - The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized. | 10-04-2012 |
20140264014 | ION TRAP DEVICE - An ion trap device is disclosed. The device includes a series of electrodes that define an ion flow path. A radio frequency (RF) field is applied to the series of electrodes such that each electrode is phase shifted approximately 180 degrees from an adjacent electrode. A DC voltage is superimposed with the RF field to create a DC gradient to drive ions in the direction of the gradient. A second RF field or DC voltage is applied to selectively trap and release the ions from the device. Further, the device may be gridless and utilized at high pressure. | 09-18-2014 |
20160005579 | MULTI-POLE ION TRAP FOR MASS SPECTROMETRY - An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis. | 01-07-2016 |