| Entries |
| Document | Title | Date |
|---|
| 20080203286 | APPARATUS AND METHOD FOR COOLING IONS - An apparatus for secondary ion mass spectrometry is provided having a target surface for supporting a sample on the target surface and an ion source configured to direct a beam of primary ions toward the sample to sputter secondary ions and neutral particles from the sample, A first chamber having an inlet provides gas to maintain high pressure at the sample for cooling the secondary ions and neutral particles, the high pressure being in the range of about 10 | 08-28-2008 |
| 20080210854 | FOREIGN MATTER OR ABNORMAL UNSMOOTHNESS INSPECTION APPARATUS AND FOREIGN MATTER OR ABNORMAL UNSMOOTHNESS INSPECTION METHOD - A foreign matter or abnormal unsmoothness inspection apparatus is constituted by a detecting member for detecting a foreign matter or abnormal unsmoothness by measuring smoothness of a surface of a substrate-like measuring object, a marking device for providing an dent on the surface of the measuring object with a predetermined horizontal distance from the foreign matter or abnormal unsmoothness, and a mass spectrum measuring device for measuring a mass spectrum of secondary ion emitted from a position with a predetermined distance from the dent by detecting the dent through impact and scanning of the surface of the measuring object with a primary ion beam. | 09-04-2008 |
| 20080217524 | Document sampler and method of sampling a document - A document sampler can be arranged to receive a document in an insertion area of the document sampler. With such arrangements, a document can be directly inserted into a document sampler without an extra step of swabbing a document with a sample collection device. By eliminating the extra step of swabbing a document, the efficiency of sample detection is improved, sample detection is performed more rapidly, and operating costs of sample detection are decreased. | 09-11-2008 |
| 20080230686 | Charged-particle detecting apparatus - The present invention relates to a charged-particle detecting apparatus having a structure which enables adjustment of a potential distribution so as to stably maintain flight loci of charged particles without depending on a change in a voltage-applied state. The charged-particle detecting apparatus comprises a first electrode, an MCP, a second electrode, a third electrode that functions as an anode, and a rear cover arranged in order along a predetermined reference axis. The third electrode is arranged on the opposite side of the MCP with respect to the second electrode, and is electrically connected to an output signal part via a capacitor. In particular, the first electrode is arranged so as to become a part of the outer surface of the charged-particle detecting apparatus, and components positioned between the first electrode and the rear cover have contours with section sizes equal to or smaller than that of the contour of the first electrode when viewed from the first electrode side toward the rear cover. | 09-25-2008 |
| 20080237457 | Method and apparatus for chromatography mass spectrometry - The results of mass spectrometry are compared; correspondences are established between individual components contained in different samples; the results of establishment of correspondences are checked; and varying components are extracted. At least two samples are compared with respect to the ion intensity corresponding to retention times and mass-to-charge ratios obtained by chromatography-mass spectrometry on the samples having a plurality of components. In ion groups observed as mass spectra, a correspondence between the retention times at which the same component is supposed to be observed is established by determining coincidence between the mass-to-charge ratios and determining that the ion intensity fall within a designated variation. | 10-02-2008 |
| 20080245961 | Nanowire Assisted Laser Desorption/Ionization Mass Spectrometric Analysis - This invention relates to a nanowire-assisted method for mass spectrometric analysis of a specimen. More specifically, by using nanowire which can fix a specimen and perform desorption/ionization of the specimen while effectively transferring laser energy to the specimen to be irradiated, thereby enabling to perform mass spectrometric analysis without using a matrix solution. This invention, by effectively performing desorption/ionization of a specimen using the above-mentioned nanowire, enables to effectively perform qualitative-, quantitative-, and micro-analyses of specimens as well as low molecular weighted specimens. Further, this invention enables to the typical device of mass spectrometric analysis used in MALDI-T of MS. In particular, this invention can perform mass spectrometric analysis of a specimen with molecular weight of less than 1,000 Da and perform quantitative analysis by fixing a specimen with a predetermined area. | 10-09-2008 |
| 20080272285 | Ion Mobility Spectrometer Comprising a Corona Discharge Ionization Element - An ion mobility spectrometer is disclosed wherein the ionization element is a corona discharge source ( | 11-06-2008 |
| 20080290266 | METHOD AND SYSTEM FOR EXTRACTING ION BEAMS COMPOSED OF MOLECULAR IONS (CLUSTER ION BEAM EXTRACTION SYSTEM) - A new type of triode extraction system, a Cluster Ion Beam Extraction System, is disclosed for broad energy range cluster ion beam extraction applications while still being applicable to atomic and molecular ion species as well. The extraction aperture plate contours are set to minimize the beam cross over and at the same time shield the source from excess extraction electric fields thus allowing smaller values of the extraction gap. In addition, a novel focusing feature is integrated into these new optics which allows the beam to be either focused or de-focused in the non-dispersive plane by using a bipolar bias voltage of only a few kV over a broad range of beam energy. This is a superior solution to a stand-alone electrostatic lens solution, for example an einzel lens, which would require tens of kV of bias voltage in order to be able to focus an energetic beam. | 11-27-2008 |
| 20080308721 | ION TRANSPORT DEVICE - A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel. | 12-18-2008 |
| 20080308722 | ELECTROSPRAY-ASSISTED LASER-INDUCED ACOUSTIC DESORPTION IONIZATION MASS SPECTROMETER AND A METHOD FOR MASS SPECTROMETRY - A mass spectrometer includes: an electrospray unit for forming liquid drops of an electrospray medium; a voltage supplying member disposed to allow the liquid drops to be laden with a plurality of charges for heading toward a receiving unit along a traveling path; a substrate having a sample surface for placement of a sample and an irradiated surface opposite to the sample surface; and a laser transmission mechanism for irradiating the irradiated surface. The substrate permits propagation of laser energy therethrough such that laser energy is passed on to at least one analyte in the sample via the substrate so that the analyte is desorbed to fly along a flying path intersecting the traveling path to enable occlusion of the analyte in the liquid drops. As a result of dwindling in size of the liquid drops, charges will pass on to the analyte to form a corresponding ionized analyte. | 12-18-2008 |
| 20080315080 | Electrostatic Trap - An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period T | 12-25-2008 |
| 20090001261 | CHROMATOGRAPH MASS ANALYSIS DATA PROCESSING APPARATUS - A chromatograph mass analysis data processing apparatus is provided for obtaining pertinent information, with a simple operation, on a compound series including a plurality of compounds whose structures and characters are similar. Based on the data obtained by a chromatograph mass analysis, a two-dimensional isointensity line graph is created and displayed with a retention time and a mass-to-charge ratio on the two axes and with a signal intensity represented with a contour (S | 01-01-2009 |
| 20090008542 | Chromatograph Mass Spectrometer - In a chromatograph mass spectrometer capable of defining an appropriate measurement time range and selectively performing a scan measurement, selected ion monitoring (SIM) measurement or simultaneous scan/SIM measurement in that time range, a total ion chromatogram | 01-08-2009 |
| 20090014637 | Mass Spectrometer - An ion guide or ion trap | 01-15-2009 |
| 20090014638 | Security Gate System and Security Gate Control Method - Provided are a security gate system and a security gate control method capable of accurately inspecting inspection targets in a short period of time. | 01-15-2009 |
| 20090014639 | Mass Spectrometer - A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source ( | 01-15-2009 |
| 20090020693 | CHROMATOGRAPH MASS ANALYSIS DATA PROCESSING APPARATUS - The invention provides a chromatograph mass analysis data processing apparatus in which operators can easily obtain information about plural compounds that characterize a difference between plural samples on the basis of the result of a multivariate analysis. A set of data collected by LC/MS analyses of plural samples is subjected to a multivariate analysis (principal component analysis) to create and display a loadings plot. On this loadings plot, the operator can specify a range A to select one or more characteristic data points that seem influential in the grouping of the plural samples. In response to this operation, one or more markings B indicating the peaks corresponding to the data points selected within the range A are displayed on an isointensity line graph whose two axes indicate the retention time and mass-to-charge ratio. These markings enable the operator to check, for example, that the compounds that are influential in the grouping of the samples belong to a specific compound series. | 01-22-2009 |
| 20090026360 | MASS ANALYSIS DATA ANALYZING APPARATUS AND PROGRAM THEREOF - In a mass analysis data analyzing apparatus, centroid data is used as mass spectrum data to be analyzed. First, peaks on the centroid data are specified in order of intensity as a standard peak for identifying an isotopic cluster. The isotopic cluster is detected by comparing an emerging pattern of peaks near the standard peak and an emerging pattern of peaks of an expected isotopic cluster in the case where each valence is assumed. The valence of the determined isotopic cluster is set as the valence of the peaks belonging to the isotopic cluster, and the peak at the forefront of cluster is selected as a monoisotopic peak. With such a mass analysis data analyzing apparatus, it is possible to determine the valence of each peak and identify the monoisotopic peak in a mass spectrum. | 01-29-2009 |
| 20090026361 | Microengineered electrode assembly - Microengineered stacked ring electrode assemblies capable of acting as either RF or DC ion guides in an ion optical system, and method of fabricating same are described. The electrodes are fabricated using planar processing as sets of grooved, proud features formed in a layer of material lying on an insulating substrate. Two such structures are then stacked together to form a set of diaphragm electrodes with closed pupils. Arrangements for fabrication by patterning, etching and bonding are described, together with methods for tapering the electrode pupils or otherwise varying the ion path. | 01-29-2009 |
| 20090026362 | GAS ANALYZER - A plurality of molecule components included in a gas are to be ionized at the same time by PI method. For instance, a plurality of molecule components included in a gas generated at a certain instance are accurately analyzed in real time based on PI method. A gas analyzer is provided with a gas transfer apparatus for transferring a gas generated from a sample in a sample chamber to an analyzing chamber; an ionizer for ionizing the gas; a quadruple filter for separating ions by mass/charge ratio; and an ion detector for detecting the separated ions. The ionizer is provided with an ionizing region arranged in the vicinity of a gas exhaust of the gas transfer apparatus, and a lamp for applying light on the ionizing region. Since the lamp outputs light which has light directivity lower than that of a laser beam and travels by spreading, the gas entered the ionizing region in the ionizer receives light in a wide range, and the gas components inside are ionized at the same time. | 01-29-2009 |
| 20090032695 | Miniaturized Ion Mobility Spectrometer - By utilizing the combination of a unique electronic ion injection control circuit in conjunction with a particularly designed drift cell construction, the instantly disclosed ion mobility spectrometer achieves increased levels of sensitivity, while achieving significant reductions in size and weight. The instant IMS is of a much simpler and easy to manufacture design, rugged and hermetically sealed, capable of operation at high temperatures to at least 250° C., and is uniquely sensitive, particularly to explosive chemicals. | 02-05-2009 |
| 20090039243 | Detection systems and dopants - An ion mobility spectrometer has a drift chamber ( | 02-12-2009 |
| 20090039244 | ION GENERATING DEVICE, METHOD FOR PRODUCING ION GENERATING DEVICE, CHARGING DEVICE, AND IMAGE FORMING APPARATUS - A surface of a discharge electrode of an ion generating device of the present invention, other than a surface in contact with a dielectric body, is coated with a protective layer made of a metal that is gold or a combination of gold and nickel. This allows the ion generating device to generate ions evenly and stably, and to have a longer life. | 02-12-2009 |
| 20090050797 | METHODS AND DEVICES FOR ATOM PROBE MASS RESOLUTION ENHANCEMENT - In an atom probe or other mass spectrometer wherein a specimen is subjected to ionizing pulses (voltage pulses, thermal pulses, etc.) which induce field evaporation of ions from the specimen, the evaporated ions are then subjected to corrective pulses which are synchronized with the ionizing pulses. These corrective pulses have a magnitude and timing sufficient to reduce the velocity distribution of the evaporated ions, thereby resulting in increased mass resolution for the atom probe/mass spectrometer. In a preferred arrangement, ionizing pulses are supplied to the specimen from a first counter electrode adjacent the specimen. The corrective pulses are then supplied from a second counter electrode which is coupled to the first via a passive or active network, with the network controlling the form (timing, amplitude, and shape) of the corrective pulses. | 02-26-2009 |
| 20090065687 | MULTIPLEXING MATRIX-ANALYTE STEREO ELECTRONIC INTERACTIONS FOR HIGH THROUGHPUT SHOTGUN METABOLOMICS - A shotgun metabolomics approach using MALDI-tandem mass spectrometry was developed for the rapid analysis of cellular metabolites. Through the use of neutral organic solvents to inactivate endogenous enzyme activities (i.e., methanol/chloroform/H | 03-12-2009 |
| 20090095896 | METHODS FOR DETECTION, IDENTIFICATION AND QUANTIFICATION OF IMPURITIES - Provided is a method comprising introducing a sample comprising a plurality of oligonucleotides into an ion pair high performance liquid chromatography column having a buffered mobile phase and allowing at least a portion of the oligonucleotides to separate; allowing the oligonucleotides to elute from the column; and introducing the oligonucleotides into a mass spectrometer and quantifying at least a portion of the oligonucleotides by mass spectrometry. In the method, at least a portion of the oligonucleotides are co-eluting oligonucleotides that differ in mass by no more than 20%; and the buffered mobile phase causes at least 50 mole percent of co-eluting oligonucleotides to have the same charge when they enter the mass spectrometer. | 04-16-2009 |
| 20090101809 | MASS SPECTROMETRY-BASED QUANTITATIVE ASSAY FOR DETERMINING ABUNDANCE OF MOLECULAR SPECIES IN A COMPOSITION - Provided herein are quantitative LC-MS methods is aimed at identifying and quantifying the molecular species in a composition. Additionally provided are compositions comprising one or more molecular species. | 04-23-2009 |
| 20090140135 | Electrode structures - This invention describes an electrode structure formed from a plurality of individual electrodes, the plurality of electrodes being arranged relative to one another to define a three dimensional geometric structure with individual ones of the plurality of electrodes located at each of the vertices of the geometric structure and wherein each electrode of the cell presents a curved surface to each other electrode of the cell. Such a structure may be configured as a RF ion guide, mass filter or ion trap. | 06-04-2009 |
| 20090146053 | MASS SPECTROMETER - In a mass spectrometer for carrying out mass analysis while microscopically observing a two-dimensional area of a sample | 06-11-2009 |
| 20090146054 | END CAP VOLTAGE CONTROL OF ION TRAPS - An ion trap for a mass spectrometer has a conductive central electrode with an aperture extending from a first open end to a second open end. A conductive first electrode end cap is disposed proximate to the first open end thereby forming a first intrinsic capacitance between the first end cap and the central electrode. A conductive second electrode end cap is disposed proximate to the second open end thereby forming a second intrinsic capacitance between the second end cap and the central electrode. A first circuit couples the second end cap to a reference potential. A signal source generating an AC trap signal is coupled to the central electrode. An excitation signal is impressed on the second end cap in response to a voltage division of the trap signal by the first intrinsic capacitance and the first circuit. | 06-11-2009 |
| 20090159789 | MASS SPECTROMETER - A laser light is linearly delivered onto the sample | 06-25-2009 |
| 20090166521 | ELECTRODE DESIGN FOR AN ION SPECTROMETER - Apparatuses and method are provided. For example, in one embodiment, a ring electrode includes a plurality of sub-rings adapted to provide an electric field inside a spectrometer. The sub-rings have an internal sub-ring radius. There is a ring insulator between adjacent sub-rings. Each said ring insulator has substantially the same internal radius as the sub-rings. In another embodiment, a method is provided for insertion of the ring electrode inside the spectrometer. | 07-02-2009 |
| 20090166522 | MASS SPECTROMETER - The analyst previously enters the mass of a fragment that desorbs in the first dissociation with other analysis conditions, as the precursor ion selection reference for the second dissociation through the input unit | 07-02-2009 |
| 20090179145 | Dopant Delivery and Detection Systems - An ion mobility spectrometer ( | 07-16-2009 |
| 20090184241 | Ion mobility spectrometer - The present invention achieves an ion mobility spectrometer which is small-sized but has higher selectivity. In an interior of a drift tube, air flow moving from a detector side to an ion source side is generated, and there are arranged, in order from an upstream side of the air flow to a downstream side thereof, a first region where a flow rate increases in a flow direction, a second region where the flow rate is constant, and a third region where the flow rate decreases. Light irradiation mechanisms for dissociating an ion are provided in the second region. | 07-23-2009 |
| 20090189063 | MASS SPECTROMETER SYSTEM - During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MS | 07-30-2009 |
| 20090200457 | AUTOMATIC CLEANING OF MALDI ION SOURCES - In an ion source that generates ions by matrix-assisted laser desorption (MALDI), ion acceleration diaphragms having apertures though which ions are accelerated and which have become contaminated by matrix material, are cleaned by temporarily heating the diaphragms. During the cleaning process, the sample support plate is moved aside but remains in the ion source housing, and the heating is preferably limited to regions surrounding the apertures in the diaphragms. In one embodiment, the diaphragms are heated by irradiation generated by infrared laser diodes. | 08-13-2009 |
| 20090218481 | High-Speed Molecular Analyzer System and Method - This invention relates to a device for the determination of the sequence of nucleic acids and other polymeric or chain type molecules. Specifically, the device analyzes a sample prepared by incorporating fluorescent dyes at the end of copies of varying lengths of the sample to be sequenced. The sample is then vaporized, charged and accelerated down an evacuated chamber. The individual molecules of the sample are accelerated to different velocities because of their different masses, which cause the molecules to be sorted by length as they travel down the evacuated chamber. Once sorted, the stream of molecules is illuminated causing the fluorescent dyes to emit light that is picked up by a detector. The output of the detector is then processed by a computer to yield of the sequence of the sample under analysis. The present invention improves over the prior art by using photo-detection of the individual molecules instead of measuring the time of flight to a detector that measure collisions. Unlike mass spectrometry, the method of the present invention does not require the extreme sensitivity required to differentiate between very small mass differences in large molecules. The present invention is therefore more robust than the prior art and well suited for extremely high throughput sequencing of large nucleic acid molecules. | 09-03-2009 |
| 20090230296 | RADIAL ARRAYS OF NANO-ELECTROSPRAY IONIZATION EMITTERS AND METHODS OF FORMING ELECTROSPRAYS - Electrospray ionization emitter arrays, as well as methods for forming electrosprays, are described. The arrays are characterized by a radial configuration of three or more nano-electrospray ionization emitters without an extractor electrode. The methods are characterized by distributing fluid flow of the liquid sample among three or more nano-electrospray ionization emitters, forming an electrospray at outlets of the emitters without utilizing an extractor electrode, and directing the electrosprays into an entrance to a mass spectrometry device. Each of the nano-electrospray ionization emitters can have a discrete channel for fluid flow. The nano-electrospray ionization emitters are circularly arranged such that each is shielded substantially equally from an electrospray-inducing electric field. | 09-17-2009 |
| 20090230297 | HIGH-VOLTAGE POWER UNIT AND MASS SPECTROMETER USING THE POWER UNIT - The output terminal P | 09-17-2009 |
| 20090230298 | DATA PROCESSOR FOR MASS SPECTROMETER - A main peak list is created with the data obtained by an MS | 09-17-2009 |
| 20090236512 | MASS SPECTROSCOPE - A mass spectroscope includes a mass analysis device having a surface provided with metallic members capable of exciting plasmons when irradiated by laser light, the mass analysis device allowing an analyte to be attached to the surface, a light radiation unit for irradiating the surface of the mass analysis device with laser light to ionize the analyte attached to the surface and desorb the analyte from the surface, and a detection unit for detecting a mass of the analyte ionized and desorbed from the surface of the mass analysis device from a time of flight of the analyte. The light radiation unit includes a polarization adjusting mechanism for adjusting a polarization direction of the laser light. | 09-24-2009 |
| 20090242747 | Removable Ion Source that does not Require Venting of the Vacuum Chamber - A method and apparatus of combining an ion volume, a lens stack, and an ion optic that similarly cooperates with a detached multipole ion guide is herein incorporated into a single sub-assembly that can be removed from a mass spectrometer instrument without venting. Such an arrangement allows an operator to clean all parts of the ion path that get contaminated in normal operation, reassemble and reinsert in a timely manner and then pump down to an acceptable vacuum without having to vent the system. | 10-01-2009 |
| 20090250603 | MAGNETIC ANALYZER APPARATUS AND METHOD FOR ION IMPLANTATION - In a magnetic analysis apparatus, high voltage insulation ( | 10-08-2009 |
| 20090256067 | Electron capture dissociation in radiofrequency ion traps - A system and method that includes injecting low-energy electrons in a radiofrequency (RF) ion trap in order to dissociate positive ions by electron capture. The system includes an ion trap, a controller to provide RF that can be switched on and off rapidly, and a source of low-energy electrons that can be turned on and off synchronously with the radiofrequency on/off periods. | 10-15-2009 |
| 20090266979 | ION ATTACHMENT MASS SPECTROMETER AND ION ATTACHMENT MASS SPECTROMETRY METHOD THEREOF - An ion attachment mass spectrometer includes an attached ion generation unit which generates attached ions by attaching positively charged metal ions to the molecules of a measurement target substance, and a mass spectrometry unit which performs mass spectrometry of the attached ions. The mass spectrometry unit includes a mass separation chamber to select attached ions having a specific mass number from the attached ions, an ionization chamber to dissociate the attached ions having the specific mass number, and a mass analysis chamber to analyze the dissociated ions. | 10-29-2009 |
| 20090272890 | MASS SPECTROMETER - A sample S is irradiated with a two-dimensionally spread ray of laser light to simultaneously ionize substances within a two-dimensional area on the sample. The resultant ions are mass-separated by a TOF mass separator | 11-05-2009 |
| 20090278036 | "DROPLET PICKUP ION SOURCE" COUPLED TO MOBILITY ANALYZER APPARATUS AND METHOD - An ion mobility analyzer includes at least one of a “differential mobility analyzer”, an “ion mobility spectrometer” and a “differential mobility spectrometer”, to which charged molecules of interest are fed. Ions are fed to the ion mobility analyzer from a “droplet pickup ion source” including an electrospray ion source at a capillary end, from which charged droplets formed from a solvent mixture having substantially none of the molecules of interest emerge. The charged droplets are pulled by an electric field into a “pickup region” filled with a buffer gas at a pressure or a region close to the surface of a sample, where the charged droplets incorporate the molecules of interest and transfer the charge of the charged droplets to the molecules of interest, when the liquid in the charged droplets has evaporated in a heated desolvation region that is separate or integral with respect to the “pickup region”. | 11-12-2009 |
| 20090283669 | Ion Implanter For Photovoltaic Cell Fabrication - Ion implanters are especially suited to meet process dose and energy demands associated with fabricating photovoltaic devices by ion implantation followed by cleaving. | 11-19-2009 |
| 20090294641 | AUXILIARY DRAG FIELD ELECTRODES - Auxiliary electrodes for creating drag fields may be provided as arrays of finger electrodes on thin substrates such as printed circuit board material for insertion between main RF electrodes of a multipole. A progressive range of voltages can be applied along lengths of the auxiliary electrodes by implementing a voltage divider that utilizes static resisters interconnecting individual finger electrodes of the arrays. Dynamic voltage variations may be applied to individual finger electrodes or to groups of the finger electrodes. | 12-03-2009 |
| 20090309013 | Electrode structure for drift tube in ion mobility spectrometer - Disclosed is an electrode structure for a drift tube in IMS comprising a ring electrode, for each of two surfaces of the ring electrode, at least a part adjacent to the inner radius is formed into a cone, and the angles formed between the cones and the axis of the ring electrode are different from each other. The electrode structure of the present invention can alleviate, even eliminate, the accumulation of space charges in the drift tube. Such structure is particularly suitable when the electric field in the drift tube is low in strength or a great number of ions pass through. Meanwhile, the structure allows a significant decrease in the size of the outer radius of the electrode, while the inner radius remains constant. In this way, it is possible to effectively reduce the outline size of the drift tube and thus make the IMS compact. | 12-17-2009 |
| 20090309014 | Method and apparatus to sharply focus aerosol particles at high flow rate and over a wide range of sizes - A method and an apparatus are described to focus sharply a wide range of particle sizes for particles suspended in a relatively high flow rate of carrier gas. The particles are accelerated through a continuously converging ladder of smooth contractions, each designed such that: (i) the flow remains laminar at substantial Reynolds numbers; (ii) a certain band of particle sizes is focused in each contraction, without substantial defocusing of larger particle focused in one or several preceding contractions; (iii) the form, length, and ratio of entry to exit diameter of each contraction, as well as the number of consecutive contractions are chosen such that all particles within a given relatively wide range of sizes are focused at the end of the ladder of contraction steps into a relatively narrow focal region. The focusing apparatus coupled to a collector device constitutes a new type of virtual impactor, termed a focusing virtual impactor, which can also be used as a powerful particle concentrator. | 12-17-2009 |
| 20090309015 | NEUTRAL/ION REACTOR IN ADIABATIC SUPERSONIC GAS FLOW FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY - The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields. | 12-17-2009 |
| 20090321624 | Ion trap, multiple electrode system and electrode for mass spectrometric analysis - An ion trap, a multiple-electrode-pole system and an electrode pole for mass spectrometric analysis. The electrode pole ( | 12-31-2009 |
| 20090321625 | Ion Implanter Having Combined Hybrid and Double Mechanical Scan Architecture - A system and method are provided for implanting ions into a workpiece in a plurality of operating ranges. A desired dosage of ions is provided, and a spot ion beam is formed from an ion source and mass analyzed by a mass analyzer. Ions are implanted into the workpiece in one of a first mode and a second mode based on the desired dosage of ions, where in the first mode, the ion beam is scanned by a beam scanning system positioned downstream of the mass analyzer and parallelized by a parallelizer positioned downstream of the beam scanning system. In the first mode, the workpiece is scanned through the scanned ion beam in at least one dimension by a workpiece scanning system. In the second mode, the ion beam is passed through the beam scanning system and parallelizer un-scanned, and the workpiece is two-dimensionally scanned through the spot ion beam. | 12-31-2009 |
| 20100006751 | MINIATURIZED NON-RADIOACTIVE ELECTRON EMITTER - A novel, compact non-radioactive electron emitter is provided with a cylindrical shape and with an interior space ( | 01-14-2010 |
| 20100006752 | REFLECTRON - A reflectron ( | 01-14-2010 |
| 20100019139 | MICRO DISCHARGE DEVICE IONIZER AND METHOD OF FABRICATING THE SAME - A micro discharge device (MDD) ionizer and a method for fabricating the MDD ionizer are disclosed. The MDD ionizer includes a dielectric barrier having a first open end connected to an electrically conductive capillary tube and a second open end connected to a sample collection capillary tube. A circular high voltage electrode can be positioned around the dielectric barrier in close linear proximity to the conductive capillary tube and sealed by a non-conductive epoxy. A plasma discharge can be formed in a flow path through the dielectric barrier when an AC potential is applied between the high voltage electrode and the electrically conductive capillary tube utilizing an electronic controller. Such a plasma discharge in the flow path of the sample achieves soft ionization of gaseous sample molecules. The high pressure region generally occurs in the plasma region (where the ionization occurs). The ions thus are drawn (i.e., pushed or pulled) toward the high vacuum region located downstream where the detector(s) can be located. | 01-28-2010 |
| 20100044557 | PARTIAL OVOIDAL FAIMS ELECTRODE - A partial ovoidal FAIMS apparatus for separating ions is presented with inner and outer electrodes that have geometrically matched convex and concave partial ovoidal surfaces, respectively, that share at least one common defining axis and display a nearly constant displacement between the opposing surfaces. The ovoidal surfaces can be that of an egg shaped ovoid, an ellipse, or a sphere. The apparatus can have at least one ion inlet and an ion outlet where the outlet is on or as near as possible to a point on the defining axis in the outer electrode and the inlet or inlets are on, near, or symmetrically disposed about the defining axis of the ovoidal surfaces. Electrical contacts to the electrodes permit the application of an asymmetric waveform and a compensation voltage to at least one of the electrodes. The electrodes are positioned, stabilized, and insulated from each other by a base plate. | 02-25-2010 |
| 20100044558 | MULTI-REFLECTING TIME-OF-FLIGHT MASS ANALYSER AND A TIME-OF-FLIGHT MASS SPECTROMETER INCLUDING THE MASS ANALYSER - A multi-reflecting TOF mass analyser has two parallel, gridless ion mirrors each having an elongated structure in a drift direction (Z). These ion mirrors provide a folded ion path formed by multiple reflections of ions in a flight direction (X), orthogonal to the drift direction (Z). The analyser also has a further gridless ion mirror for reflecting ions in the drift direction (Z). In operation ions are spatially separated according to mass-to-charge ratio due to their different flight times along the folded ion path and ions having substantially the same mass-to-charge ratio are subjected to energy focusing with respect to the flight and drift directions. | 02-25-2010 |
| 20100051798 | SYSTEMS AND METHODS FOR DECREASING SETTLING TIMES IN MS/MS - Systems and methods are provided for optimizing the performance of a mass spectrometer system when multiple measurements are made. For example, the total settling time of different components or stages of a mass spectrometer, such as a tandem mass spectrometer, are decreased by optimally ordering the measurements. | 03-04-2010 |
| 20100059670 | Two-Dimensional Radial-Ejection Ion Trap Operable as a Quadrupole Mass Filter - A two-dimensional radial-ejection ion trap is constructed from four apertured electrodes having inwardly facing hyberbolic surfaces, with each electrode being spaced from the centerline by a distance r that is greater than the hyperbolic radius r | 03-11-2010 |
| 20100065731 | QUADRUPOLE MASS SPECTROMETER - A quadruple mass spectrometer capable of reducing a settling time-period necessary in a process of changing, in a pulsed or step-like pattern, a voltage to be applied to a quadruple mass filter in a scan or SIM measurement. In the SIM measurement, an optimal settling-time calculation sub-section sets a length of the settling time-period according to a difference ΔM between a next-measurement mass value and a mass value used in an adjacent measurement, and the next-measurement mass value. This makes it possible to shorten a duration of a repetitive cycle in the SIM measurement or increase a time-period assignable to a measurement operation, while ensuring a voltage stabilization time-period sufficient to detect ions having the next-measurement mass value. | 03-18-2010 |
| 20100065732 | ANALYTICAL SYSTEM WITH PHOTONIC CRYSTAL SENSOR - A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance. | 03-18-2010 |
| 20100072357 | ELECTROSPRAY ION SOURCE WITH REDUCED ANALYTE ELECTROCHEMISTRY - An electrospray ion (ESI) source and method capable of ionizing an analyte molecule without oxidizing or reducing the analyte of interest. The ESI source can include an emitter having a liquid conduit, a working electrode having a liquid contacting surface, a spray tip, a secondary working electrode, and a charge storage coating covering partially or fully the liquid contacting surface of the working electrode. The liquid conduit, the working electrode and the secondary working electrode can be in liquid communication. The electrospray ion source can also include a counter electrode proximate to, but separated from, said spray tip. The electrospray ion source can also include a power system for applying a voltage difference between the working electrodes and a counter-electrode. The power system can deliver pulsed voltage changes to the working electrodes during operation of said electrospray ion source to minimize the surface potential of the charge storage coating. | 03-25-2010 |
| 20100090098 | RESISTIVE GLASS STRUCTURES USED TO SHAPE ELECTRIC FIELDS IN ANALYTICAL INSTRUMENTS - A reflectron lens for a time-of-flight mass spectrometer and a method of making same are disclosed. The reflectron lens includes a glass tube having a conductive surface along the length of the tube. The conductive surface has an electrical resistance gradient along its length. The electrical resistance gradient provides an electric field interior to the tube that varies in strength along the length of the tube when an electric potential is applied to opposing ends of the tube. A mass spectrometer incorporating the reflectron lens, a method of making the reflectron lens, and an apparatus for removing lead from the surface of a lead silicate glass tube are also disclosed. | 04-15-2010 |
| 20100096541 | MASS SPECTROMETER - An electrode member ( | 04-22-2010 |
| 20100102216 | CHROMATOGRAPHIC MASS SPECTROMETER - A chromatographic mass spectrometer | 04-29-2010 |
| 20100102217 | MS/MS MASS SPECTROMETER - The length of the collision cell ( | 04-29-2010 |
| 20100116979 | MASS SPECTROMETER - One virtual rod electrode is composed by a plurality of electrode plain plates arranged in the ion optical axis direction, and four virtual rod electrodes are arranged around the ion optical axis to form a virtual quadrupole rod type ion transport optical system ( | 05-13-2010 |
| 20100133428 | MASS SPECTROMETRY APPARATUS - A mass spectrometry apparatus configured to allow a user to designate an upper limit value UL together with a lower limit value, as a peak sorting condition. A data processing section is operable to determine whether respective peak intensities of a plurality of peaks appearing on a mass spectrum fall within an intensity range Ath defined by upper and lower limit values UL, LL, and exclude any peak out of the intensity range Ath. The remaining ions are selected as precursor ions, for example, in descending or ascending order of peak intensity so as to perform an MS | 06-03-2010 |
| 20100148051 | ION FILTER - An ion filter ( | 06-17-2010 |
| 20100163719 | CONVERGING-DIVERGING SUPERSONIC SHOCK DISRUPTOR FOR FLUID NEBULIZATION AND DROP FRAGMENTATION - A disrupter apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disrupter apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described. | 07-01-2010 |
| 20100193677 | Detection arrangements in mass spectrometers - An approach to extending the dynamic range of the detector of a mass spectrometer is described. In one embodiment, in the case of high intensity beams, means are provided to deflect the ion beam, after the collector slit ( | 08-05-2010 |
| 20100213363 | MASS SPECTROMETRY UNIT - A mass spectrometry unit of the present invention includes a mass spectrometry portion that detects ion current values of a gas to be measured according to mass-to-charge ratio, to thereby measure partial pressures of the gas to be measured. The mass spectrometry unit further includes: a control portion for preliminary storing a record of a mass-to-charge ratio of a specific gas that decreases a function of a specific portion of the mass spectrometry unit, in which if an ion current value with the mass-to-charge ratio of the specific gas detected by the mass spectrometry portion is not less than a predetermined value, the control portion outputs a warning signal denoting a functional decrease in the specific portion. | 08-26-2010 |
| 20100213364 | SMART FAIMS SENSOR - A smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events. | 08-26-2010 |
| 20100237231 | Apparatus and method for ion beam implantation using scanning and spot beams - An ion implantation apparatus with multiple operating modes is disclosed. The ion implantation apparatus has an ion source and an ion extraction means for forming a converging beam on AMU-non-dispersive plane therefrom. The ion implantation apparatus includes magnetic scanner prior to a magnetic analyzer for scanning the beam on the non-dispersive plane, the magnetic analyzer for selecting ions with specific mass-to-charge ratio to pass through a mass slit to project onto a substrate. A rectangular quadruple magnet is provided to collimate the scanned ion beam and fine corrections of the beam incident angles onto a target. A deceleration or acceleration system incorporating energy filtering is at downstream of the beam collimator. A two-dimensional mechanical scanning system for scanning the target is disclosed, in which a beam diagnostic means is build in. | 09-23-2010 |
| 20100243879 | High mass resolution low aberration analyzer magnet for ribbon beams and the system for ribbon beam ion implanter - The present invention provides a mass analyzing magnet which can bend a very wide charged particle ribbon beams through angles between 90 to 200 degrees. The shorter dimension of the ribbon beam is aligned with the magnetic field. The magnet can focus the longer dimension of the ribbon beam through a resolving slot inside the magnet for mass or momentum analysis. The magnet pole is shaped to increase the mass resolving power and to provide the focusing force in the direction of the shorter dimension of the ribbon beam. This magnet can achieve high mass resolving power with very small system aberrations for very wide ribbon beam. This feature is of significant value, for example, in the ion implantation industry. The ribbon beam width can be 300 mm, 450 mm and even 1000 mm. Integrated with the present invention, the ion implanter systems can be built to provide mass analyzed ribbon beams for various applications. The system will have much lower cost and much better ribbon beam quality than the ion implanters which are using conventional mass analyzing magnet. | 09-30-2010 |
| 20100243880 | RELATING TO A MASS SPECTROMETER - This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path. | 09-30-2010 |
| 20100258714 | MULTI-ELECTRODE ION TRAP - This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes. | 10-14-2010 |
| 20100264303 | ION IMPLANTER FOR PHOTOVOLTAIC CELL FABRICATION - Ion implanters are especially suited to meet process dose and energy demands associated with fabricating photovoltaic devices by ion implantation followed by cleaving. | 10-21-2010 |
| 20100308215 | System and Method for Ion Implantation with Improved Productivity and Uniformity - A method comprising introducing an injected gas (e.g., Argon, Xenon) into a beam line region comprising a magnetic scanner is provided herein. The injected gas improves beam current by enhancing (e.g., increasing, decreasing) charge neutralization of the magnetic ion beam (e.g., the ion beam at regions where the scanning magnetic field is non-zero) thereby reducing the current loss due to the zero field effect (ZFE). By reducing the current loss in regions having a magnetic field, the magnetic beam current is increased (e.g., the beam current is increased in regions where the magnetic field is non-zero) raising the overall beam current in a uniform manner over an entire scan path and thereby reducing the effect of the ZFE. In other words, the ZFE is removed by effectively minimizing it through an increase in the magnetized beam current. | 12-09-2010 |
| 20110006196 | ION MOBILITY SPECTROMETER - An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer. | 01-13-2011 |
| 20110031388 | FARADAY CUP ARRAY INTEGRATED WITH A READOUT IC AND METHOD FOR MANUFACTURE THEREOF - A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors. | 02-10-2011 |
| 20110057094 | METHOD AND APPARATUS FOR DIGITAL DIFFERENTIAL ION MOBILITY SEPARATION - A method for differential mobility separation of ions using digital-drive based high voltage fast switching electronics. The digital waveform delivered to the spectrometer is characterized by at least two substantially rectangular pulses of different amplitude and polarity. The control circuitry allows for waveform frequency, duty cycle and pulse amplitudes to be varied independently. Balanced as well as unbalanced asymmetric waveforms can be designed for optimum differential mobility separation of ions. The digital drive is designed for differential mobility spectrometers including parallel plate and segmented plate multipoles of planar symmetry, as well as multipoles of cylindrical symmetry, which may optionally be arranged in series. The use of the digital drive establishes alternating electric fields during which the displacement as a result of ion oscillation is determined by mobility coefficients. | 03-10-2011 |
| 20110095174 | Charged-particle detector - This ion detector includes an MCP and a plurality of planar dynodes respectively having a plurality of slits. The plurality of planar dynodes are stacked via spacers parallel to an electron output plane of the MCP, and the first stage planar dynode is opposed parallel to the electron output plane. In accordance with this ion detector, it is possible to obtain output signals having the linearity reaching mV order, and to shorten its pulse width to approximately 600 ps. | 04-28-2011 |
| 20110139974 | ION-TRAP MASS SPECTROMETER DRIVEN BY A MONOLITHIC PHOTODIODE ARRAY - A chip-scale ion-trap mass spectrometer driven by a monolithic photodiode array and a method of fabricating the same. A high-voltage photovoltaic source is located in proximity to the ion-trap mass spectrometer structure. The high-voltage photovoltaic source includes monolithically fabricated and serially connected photodiodes. An external light source illuminates the photodiodes to generate a high voltage across the photodiode array. An RF voltage modulation is attained by modulating the light source at a desired RF frequency. The high-voltage photodiode array may be monolithically fabricated in association with the ion-trap mass spectrometer. The photodiode array requires a small area compared to the ion-trap mass spectrometer size as the spectrometer typically possess a very small capacitance and a low power consumption. | 06-16-2011 |
| 20110253887 | CARGO SHIPMENT SECURITY ENCLOSURE, METHOD, SYSTEM, AND METHOD OF MAKING - A cargo shipment security system includes a flexible body configured to completely enclose and contain cargo within an internal environment having a predetermined pressure. The system includes a sealable vacuum port disposed on and through the body and configured to couple with a vacuum source for creating a vacuum within the internal environment. The system includes one or more sealable ports disposed on and through the body, positioned to cause a turbulent flow through a predetermined volume of the internal environment of the body when the vacuum source is applied at the vacuum port and fluid is caused to enter the internal environment. The system includes one or more detectors positioned to intercept fluid flowing from the internal environment to an external environment outside the body, in such a way as to enable detection of the presence of a substance exiting from the internal environment. | 10-20-2011 |
| 20110260046 | Tomographic Atom Probe Comprising an Electro-Optical Generator of High-Voltage Electrical Pulses - A tomographic atom probe uses electrical pulses applied to an electrode in order to carry out evaporation of the sample being analyzed. In order to produce these electrical pulses, the tomographic atom probe comprises a high-voltage generator connected to an electrode by an electrical connection comprising a chip of semiconductor material. The probe also comprises a light source which can be controlled in order to generate light pulses which are applied to the semiconductor chip. Throughout the illumination, the chip is rendered conductive, which puts the high-voltage generator and the electrode in electrical contact so that a potential step is applied to the latter. The probe also comprises means for applying a voltage step of opposite amplitude to the previous step at the end of a time interval Δt | 10-27-2011 |
| 20110266428 | APPARATUSES AND METHODS FOR GENERATING ELECTRIC FIELDS - Apparatuses and methods relating to generating an electric field are disclosed. An electric field generator may include a semiconductive material configured in a physical shape substantially different from a shape of an electric field to be generated thereby. The electric field is generated when a voltage drop exists across the semiconductive material. A method for generating an electric field may include applying a voltage to a shaped semiconductive material to generate a complex, substantially nonlinear electric field. The shape of the complex, substantially nonlinear electric field may be configured for directing charged particles to a desired location. Other apparatuses and methods are disclosed. | 11-03-2011 |
| 20120061560 | ION IMPLANTING SYSTEM - An ion implanting system includes an ion beam generator configured for generating a first ion beam; a mass separation device configured for isolating a second ion beam including required ions from the first ion beam; a holder device configured for holding a plurality of substrates, wherein the holder device and the second ion beam reciprocate relative to each other along a first direction to make the plurality of substrates pass across a projection region of the second ion beam; and a first detector configured for obtaining relevant parameters of the second ion beam. The above ion beam implanting system may increase the ion beam utilization rate. The ion implanting system further comprises a second detector arranged on the holder device which could fully scan across the projection range of the second ion beam and obtaining the relevant parameters of the second ion beam. | 03-15-2012 |
| 20120132794 | Apparatus And Components Thereof For Liquid Chromatography - The invention provides chromatographic apparatus and components manufactured from a corrosion resistant alloy typically comprising iron, nickel, chromium and molybdenum. The apparatus and components exhibit superior biocompatibility and corrosion resistance, especially to mobile phases containing chlorides. They are especially useful in HPLC and HPLC, and are particularly useful in conjunction with chromatographic separation media comprising particles smaller than 2 μm diameter. | 05-31-2012 |
| 20120153137 | METHODS FOR SEPARATING COMPOUNDS - Methods and systems for analyzing samples using multi-dimensional chromatography are disclosed. | 06-21-2012 |
| 20120175514 | Mass Spectrometer - In an ion detector, power supplies ( | 07-12-2012 |
| 20120273668 | SMART FAIMS SENSOR - A smart FAIMS sensor system and method includes a | 11-01-2012 |
| 20120286148 | QUADRUPOLE MASS SPECTROMETER - Disclosed is a quadrupole mass spectrometer, which is capable of, during an SIM measurement, maximally reducing a settling time-period necessary for an operation of changing an input voltage to a quadrupole mass filter in a staircase pattern, and preventing unwanted ions from excessively entering a detector during a course of changing between a plurality of mass values. Under a condition that a response speed of a DC voltage U to be applied to quadrupole electrodes is less than that of an amplitude of a high-frequency voltage V, a control section | 11-15-2012 |
| 20120286149 | METHOD AND APPARATUS FOR PROVIDING BEAMS OF NANODROPLETS FOR HIGH SPUTTERING RATE OF INERT MATERIALS - A method for milling of a workpiece of inert material by nanodroplet beam sputtering includes the steps of providing aliquid; electrohydrodynamically atomizing the liquid to form charged nanodroplets; and directing the atomized charged nanodroplets onto the workpiece to selectively remove material. The method is used for broad-beam milling the workpiece of inert material, for precision micromachining and/or for three dimensionally profiling organic samples via secondary ion mass spectrometry. The liquid is electrosprayed in a cone-jet mode in a vacuum and average nanodroplet diameter, nanodroplet velocity, and molecular energy of the nanodroplets is adjusted by changing liquid flow rate and the acceleration voltage applied to the ionic liquid as it is atomized. Apparatus for performing the method are also included embodiments. | 11-15-2012 |
| 20120292495 | MASS SPECTROMETER AND MASS SPECTROMETRY - A mass spectrometer possessing both high resolution and durability in a simple, compact structure compared to mass spectrometers of the related art, and characterized in possessing a linear ion trap unit containing a multipolar rod electrode including rod electrodes having fine orifices to allow passage of electrons or ions; a mechanism to move the ions inside the linear ion trap unit along the axis of the multipolar rod electrode; and a detector to selectively detect by mass, ions ejected from the linear ion trap unit. | 11-22-2012 |
| 20120298852 | SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR MASS SPECTROMETRY - A mass spectrometry system is mounted with (1) an action planning module for determining a measurement schedule provided by a combination of an MS analysis and an MS | 11-29-2012 |
| 20120326018 | HIGH-SPEED PARTICLE DETECTOR FOR DISCRIMINATING CHARGE STATES OF IONS - Detected ion charge states are discriminated in a mass spectrograph using a superconducting stripline detector (SSLD) as the detector thereof. A set of mass spectra of the singly charged or higher ions, the doubly charged or higher ions, the triply charged or higher ions (and successively higher ion charge states) are determined by measuring the mass spectra successively while decreasing the bias current flowing through the superconducting stripline detector. Then, the data of singly charged ions alone can be determined by subtracting the data of the doubly charged or higher ions from the data of the singly charged or higher ions. In a similar manner, the data of doubly charged ions alone, the data of triply charged ions alone (and similarly successively multiply charged ions) can also be determined. | 12-27-2012 |
| 20130009050 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION, TRAPPING AND ANALYSIS OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can be used to excite ions into secular motion, inductively detect the ions, and thereby generate a mass spectrum. | 01-10-2013 |
| 20130015340 | MULTIPOLE ASSEMBLY HAVING A MAIN MASS FILTER AND AN AUXILIARY MASS FILTER - A multipole rod assembly for use in a mass spectrometer has a plurality of rods aligned around and parallel to a common ion optical axis. Each rod consists of two rod pieces that are collinear with one another. Each rod piece has an opposing face that is perpendicular to the axis and faces the other rod. One rod piece has a recess is its face. The rod pieces are physically connected together with an insulating piece located between the two rod pieces to electrically de-couple the rod pieces. The insulating piece has a shape and size that allows it to fit entirely within the recess so that, during operation of the mass spectrometer, the insulating piece is substantially screened from the ion optical axis. | 01-17-2013 |
| 20130015341 | MULTIPOLE ASSEMBLY AND METHOD FOR ITS FABRICATION - A multipole rod assembly, such as used as mass analyzer, is fabricated using rods adhesively attached to shoes, which are then attached to isolation rings. A fixture is used in conjunction with precision-made spacers to precisely assemble the ion mass analyzer. The rods and shoes can be made of metal, while the isolation rings are preferably made of insulator, such as ceramic. The shoes and isolation rings need not be made to high precision, as the spacer ensures high accuracy in alignment and symmetry of the rods. Consequently, the rods are the only precision machined parts in the ion mass analyzer assembly. | 01-17-2013 |
| 20130026356 | System and Method for Ion Implantation with Improved Productivity and Uniformity - A method comprising introducing an injected gas (e.g., Argon, Xenon) into a beam line region comprising a magnetic scanner is provided herein. The injected gas improves beam current by enhancing (e.g., increasing, decreasing) charge neutralization of the magnetic ion beam (e.g., the ion beam at regions where the scanning magnetic field is non-zero) thereby reducing the current loss due to the zero field effect (ZFE). By reducing the current loss in regions having a magnetic field, the magnetic beam current is increased (e.g., the beam current is increased in regions where the magnetic field is non-zero) raising the overall beam current in a uniform manner over an entire scan path and thereby reducing the effect of the ZFE. In other words, the ZFE is removed by effectively minimizing it through an increase in the magnetized beam current. | 01-31-2013 |
| 20130032708 | ARRANGEMENT FOR A REMOVABLE ION-OPTICAL ASSEMBLY IN A MASS SPECTROMETER - A device for use in a mass spectrometer allows an ion-optical assembly to be removed, cleaned and reinserted with relatively high positioning accuracy. In particular, the device obviates the need for complex adjustments requiring special knowledge after the reinsertion. The objective is achieved by an arrangement comprising a receptacle and a mount for a removable ion-optical assembly in a mass spectrometer. Favorable implementations provide a mount and a receptacle with three pairs of complementary support elements, the three support elements on the receptacle form a support plane, and, when the mount is inserted into the receptacle, at least two pairs of support elements are engaged and the mount is aligned with respect to the support plane with the aid of the third pair of support elements. | 02-07-2013 |
| 20130082171 | Ion Trap Mass Spectrometer - An ion trap mass spectrometer with high sensitivity for detection in the high mass-to-charge ratio is provided. with separate measurement of square-wave voltages on the positive and negative electrode sides applied to a ring electrode in rectifying circuits and smoothing the measured voltages in integrating circuits, respectively, the areas of square-wave voltages on the positive and negative electrode sides are replaced with the peak values h | 04-04-2013 |
| 20130146758 | HIGH-DENSITY SAMPLE SUPPORT PLATE FOR AUTOMATED SAMPLE ALIQUOTING - A sample support plate ( | 06-13-2013 |
| 20130161505 | METHODS OF FORMING LAYERS - A system that includes an ion source, the ion source configured to produce ions having a first energy; an extractor to extract the ions; an accelerator configured to accelerate the ions; a focusing and steering device configured to focus and/or steer the accelerated ions; and a decelerator configured to decelerate the accelerated ions so that the ions have a second energy when they impact a substrate, wherein the second energy is less than the first energy. | 06-27-2013 |
| 20130214146 | MS/MS Mass Spectrometer - A mass analysis of a sample having a known mass-to-charge ratio is carried out by performing a scan at a first-stage quadrupole over a predetermined mass range, under the condition that a collision induced dissociation gas is introduced into a collision cell and a voltage applied to a third-stage quadrupole is set so that no substantial mass separation occurs in this quadrupole. Various product ions originating from a precursor ion selected by the first-stage quadrupole arrive at and are detected by a detector without being mass separated. Accordingly, based on the detection data, a data processor can obtain a relationship between the voltage applied to the first-stage quadrupole and the mass-to-charge ratio of the selected ions, with a time delay in the collision cell reflected in that relationship. This relationship is stored in a calibration data memory, to be utilized in a neutral loss scan measurement or the like. | 08-22-2013 |
| 20130221214 | MS/MS TYPE MASS SPECTROMETER AND PROGRAM THEREFOR - A method for selecting product ions at the time of performing multiple reaction monitoring (MRM) using an MS/MS type mass spectrometer is provided. Plurality of product ion scan events is prepared for certain precursor ions. In the product ion scan events, parameters for determining the cleavage conditions of the precursor ions are changed. Next, the precursor ions are introduced into a collision cell and the plurality of product ion scan events is executed, thereby obtaining a plurality of mass spectra corresponding to the respective product ion scan events. Then, the plurality of mass spectra is compared with one another, and ions corresponding to the mass peak with the highest appearance frequency are selected as product ions. Alternatively, ions having the highest cumulative signal intensity obtained by integrating the plurality of mass spectra are selected as product ions. Accordingly, optimum product ions for certain precursor ions are selected. | 08-29-2013 |
| 20130221215 | TIMING DEVICE AND METHOD - The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data. | 08-29-2013 |
| 20130228677 | Mass Spectrometric System - There is a tendency of the intensity and the shape of a spectrum to be measured transitioning with the passage of measured time, depending on the volatility and the reactivity of a component. A mass spectrometric system includes: a mass spectrometric unit that measures a specimen and outputs a mass spectrum; and an estimator that has an estimation rule on content information, the estimation rule being assigned to each component and each measurement time. The estimator estimates, based on a mass spectrum output from the mass spectrometric unit, content information on each component of a plurality of components that may be contained in the specimen in accordance with the estimation rule. | 09-05-2013 |
| 20130292560 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample | 11-07-2013 |
| 20130306852 | MICROCHANNEL PLATE - The present invention relates to a low-resistance MCP with an expanded dynamic range and excellent environment resistance, in comparison with the conventional technology. The MCP has a double structure composed of hollow first cladding glasses whose inner wall surfaces function as channel walls, and a second cladding glass having a resistivity lower than that of the first cladding glasses. | 11-21-2013 |
| 20130313421 | ION GUIDE AND MASS SPECTROMETRY DEVICE - An electrode changeover switch which switches the connection state of electrodes is provided in the wiring path between eight electrodes through, arranged rotation-symmetrically about ion optical axis, and voltage generation switch which generates square wave high voltage ±V. When switch is switched as shown in the drawing, two circumferentially adjacent rod electrodes are connected to form one set, a square wave voltage of opposite phase is applied to circumferentially adjacent sets, and an effectively quadrupole electric field is formed. When switch is switched, a square wave voltage of opposite phase is applied to circumferentially adjacent rod electrodes and an octupole electric field is formed. In this way, by switching the switch according to the mass range, etc., it becomes possible to rapidly switch the number of poles of a multipole electric field and to suitably transport ions. | 11-28-2013 |
| 20130313422 | MICROCHANNEL PLATE - The present invention relates to a low-resistance MCP with an expanded dynamic range and excellent environment resistance, in comparison with the conventional technology. The MCP has a double structure composed of hollow first cladding glasses whose inner wall surfaces function as channel walls, and a second cladding glass having an acid resistance higher than that of the first cladding glasses. | 11-28-2013 |
| 20140027627 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section and a second ion guide section. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. Electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section. | 01-30-2014 |
| 20140034824 | METHOD FOR PRODUCING A CONVERTER MODULE AND CORRESPONDING CONVERTER MODULE - A method for producing a converter module ( | 02-06-2014 |
| 20140048695 | Curved Ion Guide With Non Mass To Charge Ratio Dependent Confinement - A non-linear ion guide is disclosed comprising a plurality of electrodes. An ion guiding region is arranged between the electrodes, and the ion guiding region curves at least in a first direction. A DC voltage is applied to at least some of the electrodes in order to form a DC potential well which acts to confine ions within the ion guiding region in the first direction. | 02-20-2014 |
| 20140048696 | DC Ion Guide for Analytical Filtering/Separation - An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction. | 02-20-2014 |
| 20140048697 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 02-20-2014 |
| 20140061457 | DEVICE FOR MANIPULATING CHARGED PARTICLES - The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation. | 03-06-2014 |
| 20140191121 | TIMING DEVICE AND METHOD - The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data. | 07-10-2014 |
| 20140252217 | MASS SPECTROMETER - A mass spectrometer having a multi-stage differential pumping system with an ion lens provided in a partition wall separating a second intermediate vacuum chamber and a third intermediate vacuum chamber, the incircle radii of ion guides and the size of the opening of the ion lens are determined so that the circumferential edge of the opening is located outside the circumferential surface of a virtual tubular body straightly connecting the incircle at the rear edge of the second ion guide in the front stage and the incircle at the front edge of the third ion guide in the rear stage. Although the ion lens is located in between, the radio-frequency electric field created by the second ion guide can be effectively connected to the radio-frequency electric field created by the third ion guide through the opening of the ion lens. | 09-11-2014 |
| 20140263999 | MICROSCALE MASS SPECTROMETRY SYSTEMS, DEVICES AND RELATED METHODS - Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm | 09-18-2014 |
| 20140264000 | METHOD AND APPARATUS FOR CONTROL OF A PLASMA FOR SPECTROMETRY - A method of and apparatus for controlling the temperature of an inductively coupled or microwave induced plasma for optical emission spectrometry or mass spectrometry in which the intensities of two spectral lines of radiation emitted by the plasma are measured, and the power provided to sustain the plasma is adjusted so that the ratio of the intensities remains substantially constant. | 09-18-2014 |
| 20140299758 | CORONA DISCHARGING DEVICE AND ION MIGRATION SPECTROMETER HAVING SAME - The present invention provides a corona discharge device, comprising a first electrode including: a first substantially cylindrical inner chamber portion and a second substantially conical inner chamber portion in communication with the first inner chamber portion, wherein the second inner chamber portion has a cross sectional area that gradually enlarges in a direction away from the first inner chamber portion. The present invention also provides an ion mobility spectrometer comprising: an ionization region; and the corona discharge device disposed in the ionization region. With the above construction and structure, the ion mobility spectrometer of the present invention has the advantages that extraction of ions is facilitated and a life time of the corona electrode is lengthened. In addition, the focusing and storing electrode is used to effectively shield interference of a corona discharge pulse, and to push and focus sample ions. A designed voltage control solution is used to achieve mobility differentiating of ions, while a corona pulse is shielded to prevent variation in an ion quantity due to the corona pulse, thereby achieving an effect of stabilizing mobility spectrum lines. | 10-09-2014 |
| 20140299759 | CORONA IONIZATION DEVICE AND METHOD - A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode. | 10-09-2014 |
| 20140339413 | METHOD FOR DETERMINING THE CONTENT OF ORGANIC SILICON COMPOUNDS IN ANTHROPOGENIC AND/OR BIOGENIC GASES CONTAINING METHANE - The aim of the invention is to provide a solution by means of which the content of organic silicon compounds in anthropogenic and/or biogenic gases containing methane can be determined in the simplest and most reliable manner possible using a method for determining the content of organic silicon compounds in anthropogenic and/or biogenic gases containing methane, such as biogases, sewer gases, and landfill gases. The aim is achieved by using ion mobility spectrometry as a measurement method, wherein the anthropogenic and/or biogenic gas containing methane is used as a measurement gas. | 11-20-2014 |
| 20140339414 | DC ION FUNNELS - Systems and related methods are disclosed herein that generally involve focusing dispersed ions using one or more DC ion funnels. In some embodiments, a DC ion funnel is provided that includes a plurality of ring-shaped electrodes, each having an aperture formed therein such that the funnel defines an interior volume extending between an ion inlet and an ion outlet. A controller applies a DC potential to each of the electrodes without applying an RF potential to any of the electrodes, such that ions entering the funnel are substantially confined within said volume. The interior volume can have any of a variety of shapes, such as cylindrical, frusto-conical, and curved frusto-conical. In addition, any of a variety of DC potentials can be applied to the plurality of electrodes. | 11-20-2014 |
| 20140339415 | INSTRUMENT FOR SIZING NANOPARTICLES AND A COMPONENT THEREFOR - An improved nanoparticle sizing apparatus comprised of a unipolar charger operatively coupled to a radial differential mobility analyzer in combination with a condensation particle counter and powered by a power source such as a battery or solar cell, thereby providing a portable sizing device. | 11-20-2014 |
| 20140353483 | ION PROCESSING UTILIZING SEGMENTED VACUUM MANIFOLD - An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell. | 12-04-2014 |
| 20140367563 | ASYMMETRIC WAVEFORM PULSE GENERATOR AND FAIMS ION DETECTOR EMPLOYING SAME - An asymmetric waveform pulse generator comprises a metallic oxide semiconductor field effect transistor (MOSFET) bridge circuit, which includes a plurality of MOSFETs for inverting high voltage DC voltage to asymmetric waveform pulses. The asymmetric waveform pulse generator further comprises a pulse-width modulating (PWM) circuit for generating PWM signals, and a plurality of isolation driving circuits corresponding to the plurality of MOSFETs, for controlling switching on/off of the plurality of MOSFETs in the MOSFET bridge circuit based on the PWM signals generated by the PWM circuit. Each of the isolation driving circuits comprises an isolation transformer for isolating the MOSFET bridge circuit from the PWM circuit. A FAIMS ion detector employing the asymmetric waveform pulse generator is also disclosed. | 12-18-2014 |
| 20150008311 | REDUCTION OF CROSS-TALK BETWEEN RF COMPONENTS IN A MASS SPECTROMETER - The invention generally relates to an assembly of a first RF component and a second RF component in a mass spectrometer, the first RF component comprising a first set of electrodes and the second RF component comprising a second set of electrodes, wherein the RF components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce RF electric field cross-talk between the electrodes of the first set and those of the second set. The invention affords for technically simple and economic means to reduce cross-talk or capacitive coupling between adjacent RF components in a mass spectrometer. | 01-08-2015 |
| 20150021468 | COLLISION CELLS AND METHODS OF USING THEM - Certain embodiments described herein are directed to collision cells that comprise one or more integrated lenses. In some examples, a lens is coupled to two sections of a sectioned quadrature rod assembly, the lens comprising an aperture and a plurality of separate conductive elements disposed each one side of the lens, in which a respective disposed conductive element on one side of the lens is configured to electrically couple to a first, second, third, and fourth pole segments of the sectioned quadrature rod assembly. | 01-22-2015 |
| 20150028196 | FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY FILTER - Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes. | 01-29-2015 |
| 20150034812 | MULTI-DIMENSIONAL CHROMATOGRAPH SYSTEM - In a two-dimensional LC system configured to introduce components trapped in a trap column during a fractionation period T into a second-dimension column, separate components, and then detect the components using a mass spectrometer, a data collection unit receives a signal which indicates timing to delimit the fractionation period T, determines the first data item in the fractionation period T, adds measurement start point identification information to the first data item, and stores all the data in a data storage unit. A two-dimensional chromatogram creation unit recognizes the first data item in each fractionation period T from the read data, and create a two-dimensional chromatogram by aligning data so that the first data items will be aligned at the top along an abscissa. | 02-05-2015 |
| 20150060655 | Ion Guide Construction Method - A method of constructing an ion guide is disclosed comprising providing an elongated spine member and a plurality of plates. Each plate comprises an aperture therethrough for receiving the spine member and at least one electrode for use in guiding ions. The apertures of the plates are arranged around the spine member and the plates are arranged along the spine member. The plates are then locked in position on the spine member such that the plates are fixed axially with respect to the spine member and so that the electrodes of the plates are arranged so as to form an array of electrodes for use in guiding ions. | 03-05-2015 |
| 20150076338 | MASS SPECTROMETER, CONTROL SYSTEM AND METHODS OF OPERATING AND ASSEMBLING A MASS SPECTROMETER - A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network. The mass spectrometer can also include a scheduler operable to introduce discrete packets of instructions to the network at predetermined times to instruct at least one module to perform a predetermined operation. | 03-19-2015 |
| 20150090872 | Mass Spectrometer - A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal output; temporarily storing the data frame types in a memory block and reading a data frame from the memory block and determining its data frame type and according to its data frame type compressing the data frame according to one or more compression algorithms to generate a compressed data output stream. | 04-02-2015 |
| 20150102213 | ELECTRODE DEVICE WITH PRE- AND/OR POSTFILTERS AND MANUFACTURING METHOD THEREFOR, AS WELL AS A MASS SPECTROMETER WITH SUCH AN ELECTRODE DEVICE - A method manufactures a multipolar electrode device, in particular a multipole for use in a mass spectrometer, wherein the electrode device includes at least one main filter and at least one pre- and/or postfilter. The electrode blanks are separated in several sections for producing the pre- and/or postfilters, which are thereby maintained by a holder in a constant relative position to each other. Moreover, an electrode device may be used in a mass spectrometer and a mass spectrometer may have such a multipolar electrode device. | 04-16-2015 |
| 20150108340 | SWITCH CIRCUIT, MASS SPECTROMETER, AND CONTROL METHOD FOR SWITCH CIRCUIT - To provide a switch circuit in which ON/OFF control can be realized even in a state where high voltage is not applied, and high voltage can be completely lowered to the ground. | 04-23-2015 |
| 20150108341 | MASS SPECTROMETER AND MASS SPECTROMETRY - A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed. When urine is measured, the mass spectrometer detects the substances contained in the urine and automatically determines whether the sample is urine. The mass spectrometer then automatically selects an analysis condition specific to urine samples to make a measurement. Also with respect to sweat and saliva, the mass spectrometer similarly selects a specific analysis condition. The mass spectrometer automatically determines whether a sample, which is an internal standard sample contained in a sample case, is being measured on a measurement-by-measurement basis and automatically displays any error, interrupts the measurement, or carries out other processing. | 04-23-2015 |
| 20150129755 | COMPACT HIGH VOLTAGE RF GENERATOR USING A SELF-RESONANT INDUCTOR - RF generators including active devices driving series resonant circuits are described. The series resonant circuits include a self-resonant dual inductor. The RF generators can be used to drive capacitive loads. | 05-14-2015 |
| 20150129756 | INTEGRATED CAPACITOR TRANSIMPEDANCE AMPLIFIER - Spectrometers including integrated capacitive detectors are described. An integrated capacitive detector integrates ion current from the collector ( | 05-14-2015 |
| 20150136964 | ION FOCUSING - The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure. | 05-21-2015 |
| 20150136965 | CAPACITIVE TRANSIMPEDANCE AMPLIFIER WITH OFFSET - Spectrometers including integrated capacitive detectors are described. An integrated capacitive detector integrates ion current from the collector ( | 05-21-2015 |
| 20150136966 | SYSTEMS AND METHODS OF SUPPRESSING UNWANTED IONS - Certain embodiments described herein are directed to systems including a cell downstream of a mass analyzer. In some instances, the cell is configured as a reaction cell, a collision cell or a reaction/collision cell. The system can be used to suppress unwanted ions and/or remove interfering ions from a stream comprising a plurality of ions. | 05-21-2015 |
| 20150136967 | DECELERATION APPARATUS FOR RIBBON AND SPOT BEAMS - A deceleration apparatus capable of decelerating a short spot beam or a tall ribbon beam is disclosed. In either case, effects tending to degrade the shape of the beam profile are controlled. Caps to shield the ion beam from external potentials are provided. Electrodes whose position and potentials are adjustable are provided, on opposite sides of the beam, to ensure that the shape of the decelerating and deflecting electric fields does not significantly deviate from the optimum shape, even in the presence of the significant space-charge of high current low-energy beams of heavy ions. | 05-21-2015 |
| 20150311054 | ULTRA-COMPACT PLASMA SPECTROMETER - Various examples are provided for collimator assemblies and/or energy analyzer arrays of plasma spectrometers. In one example, among others, an ultra-compact plasma spectrometer includes a collimator assembly; an energy analyzer array that receives charged particles from the collimator; and a detector plate that detects charged particles exiting the energy analyzer array. The energy analyzer array can include a plurality of analyzer plates having distinct energy channels. In another example, a method includes bonding a stack of analyzer plates to form an energy analyzer array, affixing a collimator assembly to the entrance surface of the energy analyzer array, and affixing an array of detectors to the exit surface of the energy analyzer array. The analyzer plates include energy analyzer bands extending from the entrance surface to the exit surface. The aperture arrays and the detectors can align with the energy analyzer bands. | 10-29-2015 |
| 20150311666 | COMPACT ULTRA-SHORT PULSE SOURCE AMPLIFIERS - The present invention relates to compact, low noise, ultra-short pulse sources based on fiber amplifiers, and various applications thereof. At least one implementation includes an optical amplification system having a fiber laser seed source producing seed pulses at a repetition rate corresponding to the fiber laser cavity round trip time. A nonlinear pulse transformer, comprising a fiber length greater than about 10 m, receives a seed pulse at its input and produces a spectrally broadened output pulse at its output, the output pulse having a spectral bandwidth which is more than 1.5 times a spectral bandwidth of a seed pulse. A fiber power amplifier receives and amplifies spectrally broadened output pulses. A pulse compressor is configured to temporally compress spectrally broadened pulses amplified by said power amplifier. Applications include micro-machining, ophthalmology, molecular desorption or ionization, mass-spectroscopy, and/or laser-based, biological tissue processing. | 10-29-2015 |
| 20150323500 | A SPATIALLY ALTERNATING ASYMMETRIC FIELD ION MOBILITY SPECTROMETRY - One embodiment of the present disclosure provides an ion mobility spectrometry (IMS) device for performing chemical analysis. The IMS device includes a first set of electrodes arranged linearly in a first direction and separated by a first set of gaps. The IMS device includes a second set of electrodes positioned directly opposing the first set of electrodes to match the first set of electrodes on a one-to-one basis, wherein the second set of electrodes are separated by a second set of gaps. The IMS device includes a drift region between the first set of electrodes and the second set of electrodes, wherein charged particles enter at a first end of the drift region and traverse the drift region along the first direction. The IMS device additionally includes a detector positioned at a second end of the drift region and configured to receive charged particles exiting the drift region. | 11-12-2015 |
| 20150380228 | AN ANALYTICAL APPARATUS UTILIZING ELECTRON IMPACT IONIZATION - An analytical apparatus ( | 12-31-2015 |
| 20160025679 | INTERDIGITATED ELECTRODE CONFIGURATION FOR ION FILTER - An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes. | 01-28-2016 |
| 20160042930 | Systems and Methods for Using Interleaving Window Widths in Tandem Mass Spectrometry - Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width. | 02-11-2016 |
| 20160086758 | LIQUID DROPLET INJECTING APPARATUS AND ION SOURCE - In the known liquid droplet injecting apparatus, when a tube and a nozzle are heated in order to prevent deposition of a solid source material of liquid droplets, the efficiency of injection of liquid droplets into a vacuum vessel is decreased by evaporation of the liquid droplets. The present invention provides a liquid droplet injecting apparatus capable of efficiently injecting liquid droplets into a vacuum vessel. The liquid droplet injecting apparatus includes a liquid container which holds a liquid and whose inside pressure can be adjusted, a liquid droplet generating unit configured to generate liquid droplets from the liquid held in the liquid container, a nozzle which injects the liquid droplets generated in the liquid container, a connecting tube which connects the nozzle and the liquid container, and a first heating unit configured to heat at least one of the connecting tube and the nozzle. | 03-24-2016 |
| 20160141145 | Micro Machined Two Dimensional Faraday Collector Grid - A system for detecting particles in a gas stream comprises a Faraday collector separating charged particles into positive and negative streams to be detected. The Faraday collector includes a plurality of interdigitated wires, with a first plurality of wires charged with a positive potential and a second plurality of wires charged with a negative potential to separate particles in the gas stream into the positive and negative streams. | 05-19-2016 |
| 20160189949 | TRIPLE QUADRUPOLE MASS SPECTROMETER - The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an MRM measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound. Based on the approximate equation read from the storage section, an optimum collision-gas pressure calculator determines the optimum collision-gas pressure for the specified precursor ion or product ion, and sets this pressure as a measurement condition for the apparatus. | 06-30-2016 |
| 20160379809 | DETECTORS AND METHODS OF USING THEM - Certain embodiments described herein are directed to detectors and systems using them. In some examples, the detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In some instances, an analog signal from a non-saturated dynode is measured and cross-calibrated with a pulse count signal to extend the dynamic range of the detector. | 12-29-2016 |
| 20180024068 | SYSTEM FOR ANALYZING ONLINE-TRANSFERRED ASSAY SAMPLES | 01-25-2018 |
