| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 210657000 | Utilizing rotating column | 12 |
| 20080264865 | Methods and Compositions for Chromatography - The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications. | 10-30-2008 |
| 20090039024 | APPARATUS AND METHODS FOR PERFORMING STEPS OF A MULTI-STEP PROCESS IN PARALLEL - Embodiments of the present invention feature a device ( | 02-12-2009 |
| 20090039025 | METHOD AND DEVICE FOR SEPARATING CONSTITUENTS OF A LIQUID FEED BY LIQUID-LIQUID CENTRIFUGAL CHROMATOGRAPHY - The invention relates to a method for separating constituents of a liquid feed by liquid-liquid centrifugal chromatography and to a device for implementing it. Constituents (A, B) having different partition coefficients such that they are respectively carried along at unequal velocities by a light solvent (l) and a heavier solvent (L), the feed is continuously injected at an intermediate point of a separation column (col), successive cycles comprising alternately a heavy solvent injection stage and a light solvent injection stage are carried out respectively at the two ends of the column consisting of the interconnection in series of at least one set of separation cells, and the separated solvents (FA, FB) are collected during each one of said stages at the column ends opposite the solvent injection points. | 02-12-2009 |
| 20090050567 | Method and device for chromatographic purification - A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), is proposed. The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (α, β, γ, δ), in which the first section (α) is provided with at least one inlet of solvent (s) and at least one outlet for purified intermediate product (B), such that it washes the purified intermediate product (B) out of the system, but keeps the heavy impurities (C) inside the section (α), the one inlet of solvent (β) and at least one outlet connected to an inlet of the fourth section (δ), such that it washes the intermediate product (B), which is contaminated with heavy impurities (C) into the fourth section (δ) through said outlet, but keeps the pure heavy impurities (C) inside the section (β), the third section (γ) is provided with at least one inlet of solvent (s) and an outlet for heavy impurities (C), such that it washes out the heavy impurities (C) through said outlet and cleans the chromatographic column(s), the fourth section (δ) is provided with at least one inlet to receive output of the outlet of the second section (β) as well as at least one inlet for feeding in the multi-component mixture (F) and at least one outlet for light impurities (A), such that it washes the light impurities (A) out of the system, but keeps the intermediate product (B) inside the section (δ), wherein after or within a switch time (t*) the last column from the first section (α) is moved to the first position of the second section (β), the last column of the second section (β) is moved to the first position of the third section (γ), the last column of the third section (γ) is moved to the first position of the fourth section (δ) and the last column of the fourth section (δ) is moved to become the first column of the first section (α). | 02-26-2009 |
| 20100116744 | Device For The Rotor-Stator Homogenization Of Heterogeneous Samples And Use Of Such - Disclosed is a rotor-stator homogenization device which is characterized in that a rotor-stator homogenizer is connected to a reaction vessel via a joining system, and/or homogenization surfaces are used, and/or a rotor-stator homogenizer is used that is suitable for transferring material. Also disclosed is a method which utilizes said device and is characterized in that the reproducibility, efficiency, yield, waste disposal, automation of the rotor-stator homogenization, etc. is improved, for example, while the risk of contaminations is reduced. | 05-13-2010 |
| 20100230353 | METHODS AND APPARATUS FOR CENTRIFUGAL LIQUID CHROMATOGRAPHY - Apparatus and methods related to centrifugal liquid chromatography are described. An angular velocity can be simultaneously imparted to a large number of chromatographic enclosures. Via centrifugal forces, a mobile phase fluid including a sample can be driven through a stationary phase within the chromatographic enclosure to perform a chromatographic separation process on components of the sample. The use of centrifugation as a driving force can allow significantly smaller stationary phase particles to be employed as compared to high performance liquid chromatography (HPLC). Further, for an equivalent chromatographic separation process, the use of centrifugation can provide much greater separation efficiencies than HPLC. | 09-16-2010 |
| 20100230354 | METHODS AND APPARATUS FOR CENTRIFUGAL LIQUID CHROMATOGRAPHY - Apparatus and methods related to centrifugal liquid chromatography are described. An angular velocity can be simultaneously imparted to a large number of chromatographic enclosures. Via centrifugal forces, a mobile phase fluid including a sample can be driven through a stationary phase within the chromatographic enclosure to perform a chromatographic separation process on components of the sample. The use of centrifugation as a driving force can allow significantly smaller stationary phase particles to be employed as compared to high performance liquid chromatography (HPLC). Further, for an equivalent chromatographic separation process, the use of centrifugation can provide much greater separation efficiencies than HPLC. | 09-16-2010 |
| 20100230355 | METHODS AND APPARATUS FOR CENTRIFUGAL LIQUID CHROMATOGRAPHY - Apparatus and methods related to centrifugal liquid chromatography are described. An angular velocity can be simultaneously imparted to a large number of chromatographic enclosures. Via centrifugal forces, a mobile phase fluid including a sample can be driven through a stationary phase within the chromatographic enclosure to perform a chromatographic separation process on components of the sample. The use of centrifugation as a driving force can allow significantly smaller stationary phase particles to be employed as compared to high performance liquid chromatography (HPLC). Further, for an equivalent chromatographic separation process, the use of centrifugation can provide much greater separation efficiencies than HPLC. | 09-16-2010 |
| 20100252503 | Centrifugal Partitioning Chromatography Device and Method Implemented by this Device - The present invention relates to a centrifugal partitioning chromatography device for separating a liquid having at least two phases, and to a centrifugal partitioning chromatography method implemented by this device. A chromatography device according to the invention comprises at least one flat ring ( | 10-07-2010 |
| 20110120951 | APPARATUS AND METHODS FOR PACKING CHROMATOGRAPHY COLUMNS - A chromatographic apparatus may include a hydraulic lifting mechanism axially movable from a lowered position to a raised position such that a column and flange of the apparatus are axially movable with the hydraulic lifting mechanism. In a packing system, a mobile column module may be moved into engagement with a packing station by engaging a flange of the column module with a fixture of the packing station. After packing a column of the column module, the column module may be removed from the packing station with a piston head locked in the column to maintain packing pressure. The packing station may be utilized to unpack the column. A hydraulic lifting mechanism may be operated to lower one or more portions of the column module such that the one or more portions may be separately removed from the packing system. | 05-26-2011 |
| 20120031845 | Devices and Methods for the Purification, Isolation, Desalting or Buffer/Solvent Exchange of Substances - A spin column device, which contains a rigid porous filter that retains its shape during centrifugation, chromatography methods using the device to isolate a desired substance, e.g., a biological molecule, from other substances in a mixture, and kits containing the device with one or more reagents for use in the method. | 02-09-2012 |
| 20120037567 | Countercurrent chromatography rotor - The present invention describes a method for constructing a spiral tube support apparatus used in countercurrent chromatography, improvements to countercurrent chromatography tube support design, and methods of using the improved countercurrent chromatography apparatus. The spiral tube support apparatus may be constructed by a shape forming process such as a three dimensional printing process that in turn uses a laser sintering technique, and can be made out of any easily formed material. Shape changes on both the tube support and the top improve the performance of the tube support and ease of manufacturing. The improved tube support and new method of creation permit use in both micro or macro scale preparations and use in small or large molecule preparations. In particular, specific solvent systems are described that permit purification of proteins. | 02-16-2012 |
