| Entries |
| Document | Title | Date |
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| 20080197076 | TWO STAGE HEMOFILTRATION THAT GENERATES REPLACEMENT FLUID - The present invention relates to a system for two-stage blood dialysis of a patient. In one embodiment, the system comprises a first filtration device for receiving the blood from the patient and for producing a first filtrate and processed blood. The system further comprises a second filtration device for receiving the first filtrate and producing replacement fluid and waste product. At least one of the first and second filtration devices preferably comprises a Taylor vortex-enhanced blood filtration device. | 08-21-2008 |
| 20080203023 | LAST-CHANCE QUALITY CHECK AND/OR AIR/PATHOGEN FILTGER FOR INFUSION SYSTEMS - Blood treatment system and method for high rate hemofiltration ensures against pyrogenic patient reaction by providing various mechanisms for filtering replacement fluid to remove endotoxins and other safety features including detecting incorrect fluid administration. | 08-28-2008 |
| 20080237127 | Polysulfone Hemodialyzer - An object of the present invention is to provide a polysulfone hemodialyzer with large membrane area that exhibits an unprecedented high dialytic performance over a wide molecular weight range from urea to β | 10-02-2008 |
| 20080237128 | Process and an Apparatus for Filling and/or Rinsing an Extracorporeal Blood Circuit - A patient end of a venous blood line ( | 10-02-2008 |
| 20090032469 | FILTER FOR BODY FLUIDS - A filter for body fluids includes a housing with a filtering element. The filtering element is made of a filtering material pleated and wrapped in a cylindrical configuration. The pleated material includes an alternation of long pleats and short pleats. Intermediate length pleats with an intermediate length may also be present. The alternation may include, for example, each long pleat interposed between two short pleats or each long pleat interposed between two pairs of short pleats. | 02-05-2009 |
| 20090095679 | HEMODIALYSIS SYSTEMS AND METHODS - Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments. | 04-16-2009 |
| 20090101576 | PRIMING AND AIR REMOVAL SYSTEMS AND METHODS FOR DIALYSIS - A renal treatment fluid priming method includes priming an extracorporeal circuit connected to a patient with a physiologically compatible fluid, the extracorporeal circuit including an arterial line, a venous line and blood compartment of a blood filter; and pumping from a renal treatment fluid line in communication with the blood filter (i) pulling blood from the patient through the arterial line to flush the physiologically compatible fluid through the arterial line and the blood filter compartment into the renal treatment fluid line and (ii) pulling blood from the patient through the venous line to flush the physiologically compatible fluid through the venous line and the blood filter compartment into the renal treatment fluid line, such that a greater volume of blood is pulled from the patient via (i) and (ii) than a volume of the extracorporeal circuit. | 04-23-2009 |
| 20090101577 | Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements - The volume of fluid removed from a patient during ultrafiltration is controlled automatically on the basis of central venous pressure (CVP) measurements. In one embodiment, a central venous catheter (CVC) is used for accessing blood during dialysis. A sensor located at the tip of the catheter or inside the dialysis machine is used to periodically measure CVP. CVP feedback data helps prevent the excessive removal of fluids from the patient. | 04-23-2009 |
| 20090114595 | System and Method for Regeneration of a Fluid - A system comprising a blood circuit including a membrane arranged in a blood filter ( | 05-07-2009 |
| 20090211977 | THROUGH-PLATE MICROCHANNEL TRANSFER DEVICES - The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components. | 08-27-2009 |
| 20090218283 | Dialysis cell and tray for dialysis cells - A dialysis cell is provided for the measurement of free thyroxine. The dialysis cell preferably includes a polyhedral housing including a top, a bottom and four sides. The dialysis cell is made up of a buffer portion and serum portion. The buffer portion includes a cavity and the serum portion includes a cavity which, when the buffer portion and serum portion are assembled together, form a central chamber. The central chamber is divided by a vertically aligned dialysis membrane held in place by two O-rings. Buffer is introduced into the dialysis cell's buffer portion through a buffer inlet extending from the dialysis cell's top side to the buffer portion's cavity. Similarly, serum is introduced into the serum portion through an inlet which extends from an opening formed on the dialysis cell's top to the serum portion's cavity. | 09-03-2009 |
| 20090294359 | PRIMING SYSTEM AND METHOD USING PUMPING AND GRAVITY - A dialysis system includes a pump actuator; a disposable cassette having a pump chamber operable with the pump actuator; a patient line connected to the disposable cassette and in fluid communication with the pump chamber; and a logic implementor configured to prime the patient line according to a sequence in which (i) the pump actuator activates the pump chamber to partially prime the patient line and (ii) a remainder of the patient line is primed via gravity. | 12-03-2009 |
| 20100000944 | CONTROL EQUIPMENT AND METHOD FOR AN EXTRACORPOREAL BLOOD CIRCUIT - Control equipment for an extracorporeal blood circuit ( | 01-07-2010 |
| 20100012588 | SYSTEM AND METHOD FOR THE EXTRA-CORPOREAL PURIFICATION OF BLOOD OF PATHOGENIC ENZYMES - The invention concerns an extra-corporeal system and method to purify blood of pathogenic enzymes which initiate tumoral processes as well as evoke dystrophic muscular lesion, including enzymes of the group of cysteine peptidases, in particular of cathepsins B and L and calpain, this system being intended for removing these proteins from the blood in order to eliminate the degradation of the body's cells caused by the presence of these proteins in the blood. | 01-21-2010 |
| 20100018923 | DIALYSIS SYSTEM WITH FLOW REGULATION DEVICE - A dialysis system includes a dialysis machine with a variable fluid demand including at least a lower demand and a higher demand. A fluid source is in fluid communication with the dialysis machine and provides fluid to the dialysis machine at a fluid flow rate. A flow regulation device includes a fluid inlet in fluid communication with the fluid source and a fluid outlet in fluid communication with the dialysis machine. The flow regulation device is operable to expand and contract to provide a variable internal volume. The flow regulation device expands when the dialysis machine has the lower demand and contracts when the dialysis machine has the higher demand. | 01-28-2010 |
| 20100032376 | MEMBRANE UNIT ELEMENT, SEMIPERMEABLE MEMBRANE, FILTRATION DEVICE, AND PROCESSES FOR MANUFACTURING THE SAME - The object of the invention is a unit element forming a membrane comprising a semi-permeable material able to separate in two compartments a filtration device for extracorporeal treatment of a fluid such as blood or plasma, said material being negatively charged, said element having a first internal face intended to be in direct contact with blood or plasma and a second external face intended to be in contact with filtrate, wherein said second face of said element is treated on the surface by one selected in the group comprising at least a cationic polymer, a mixture of polymers of which at least one polymer is cationic. The unit element can also have said first face treated on the surface by one selected in the group comprising: at least one cationic polymer, a mixture of polymers of which at least one polymer is cationic. | 02-11-2010 |
| 20100044314 | POLYARYLETHER COMPOSITIONS BEARING ZWITTERION FUNCTIONALITIES - A method for making a polysulfone having zwitterionic functionality comprising reacting a piperazine amine functionalized polysulfone with sultone is described as are blends with other polymers. Membranes containing polysulfones having zwitterionic functionality are also provided. Membranes thus formed are used in hemodialysis, hemofiltration, and water purification. | 02-25-2010 |
| 20100051551 | REAGENT SUPPLY FOR A HEMODIALYSIS SYSTEM - A reagent supply arrangement for a hemodialysis system may include an E-prong connector having three parallel prongs with two outer prongs arranged in a common plane and a center prong arranged above the common plane, a first supply line for a first reagent connected in fluid communication with one of the outer prongs, a second supply line for a second reagent connected in fluid communication with the other of the outer prongs, a liquid line connected in fluid communication with the center prong, and a container for housing the first reagent having an inlet connected to the liquid line and an outlet connected to the first supply line for the first reagent. The E-prong connector may help prevent the improper connection to the dialysis unit, e.g., because the prong arrangement ensures connection in only one way to the dialysis unit. | 03-04-2010 |
| 20100078385 | BLOOD CIRCUIT, BLOOD PURIFICATION CONTROL APPARATUS, AND PRIMING METHOD - The present invention provides a blood circuit capable of automatically performing priming for safe treatments. | 04-01-2010 |
| 20100108606 | SYSTEMS AND METHODS FOR PERFORMING HEMODIALYSIS - Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at least one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemofiltration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus. | 05-06-2010 |
| 20100116740 | Priming System and Method for Dialysis Systems - The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment. | 05-13-2010 |
| 20100163488 | HOLLOW FIBER CAPILLARY MEMBRANE AND METHOD FOR THE PRODUCTION THEREOF - A hollow fiber membrane made of two coextruded layers A and B, wherein layer B has a non-woven type structure having a mesh size of 0.1 to 10 μm and layer A has a porous structure. A method for producing a membrane according to the invention and the use thereof is also disclosed. | 07-01-2010 |
| 20100170850 | FILTER DEVICE, PREFERABLY A HOLLOW FIBER DIALYSER WITH CURLED HOLLOW FIBERS - The invention relates to a filter device, preferably for hemodialysis, that consists of a cylindrical filter housing and a bundle of curled hollow fibers. The bundle is arranged in the filter housing. According to the invention, the curled hollow fibers are provided with an essentially sinusoidal texture and a wavelength that is defined by means of certain limits. The invention also relates to a curled hollow fiber and a method for filling a hollow fiber dialyser. | 07-08-2010 |
| 20100187176 | HAEMODIALFILTRATION METHOD AND APPARATUS - Device for haemodiafiltration, which comprises a first circuit for a dialysis solution and a second circuit for blood, so that the toxic substances from the blood flow pass into the dialysis liquid within a haemofilter ( | 07-29-2010 |
| 20100219129 | CONTROL APPARATUS AND CONTROL METHOD FOR A BLOOD TREATMENT EQUIPMENT - A controller for blood treatment equipment comprising a treatment unit including a semipermeable membrane separating the treatment unit into a first compartment for the circulation of blood and a second compartment for the circulation of a treatment liquid is enclosed. The controller is adapted to receive one or more entries of information measured during the course of a treatment procedure, to calculate from said measured information a value of a significant parameter indicative of the progress of an extracorporeal blood treatment carried out by the equipment. The controller is also adapted to compare the calculated significant parameter to a prescribed reference value for the same parameter and to generate at least one output control signal responsive to said comparison for automatically controlling one or more operations performed by the equipment. Equipment comprising the controller and a control method the controller can be programmed to carry out are also disclosed. | 09-02-2010 |
| 20100288703 | Novel Fluid Management System for Accurate Continuous Hemofiltration in Extracorporeal Membrane Oxygenation (ECMO) - A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed. | 11-18-2010 |
| 20100326916 | DIALYSIS SYSTEM - A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. | 12-30-2010 |
| 20110017667 | MODULAR HEMOFILTRATION APPARATUS AND METHOD FOR CARRYING OUT NEONATAL AND PEDIATRIC CRRT - An apparatus configured for carrying out CRRT on patients weighing up to about 20 kg incorporates a control unit having a blood pump and a plurality of fluid pumps mounted thereon, and a controller configured for operating the blood pump and fluid pumps, and an interactive operator control system including an operator interface screen operatively connected to the controller, the controller including software configured to operate the apparatus in response to operator input selections. The interactive operator control system includes operator inputs for setting patient weight, blood pump flow rate and fluid pump flow rates and the controller is configured to calculate and display maximum allowable fluid gain or loss based solely on patient weight settings between zero kg and about 20 kg and trigger warnings and alarms for selected or calculated levels of patient fluid gain or loss and stop operation of the pumps or termination of CRRT in response to patient fluid gain or loss in excess of the maximum. | 01-27-2011 |
| 20110036773 | METHOD OF OPERATING A BLOOD TREATMENT APPARATUS, AND BLOOD VOLUME MONITOR AND BLOOD TREATMENT APPARATUS FOR IMPLEMENTING THE METHOD - The present invention proposes a method of operating a blood treatment apparatus for the extracorporeal blood treatment of a patient , a blood volume monitor for monitoring an extracorporeal blood treatment of the patient by means of a blood treatment apparatus, and a blood treatment apparatus. | 02-17-2011 |
| 20110056884 | SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE - The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid. | 03-10-2011 |
| 20110089111 | HEMODIALYSIS APPARATUS AND METHOD FOR HEMODIALYSIS - A hemodialysis apparatus includes a dialyzing device, a measuring device and a calculation device. The dialyzing device dialyzes and ultrafiltrates blood of a patient circulating extracorporeally to perform hemodialysis treatment. The measuring device measures a variation rate of a body weight of the patient and a variation rate of a predetermined blood benchmark during the hemodialysis treatment using the dialyzing device. The calculation device calculates, during the hemodialysis treatment, a parameter relating the variation rate of the body weight and the variation rate of the predetermined blood benchmark to each other, and correlating to a dry weight of the patient. | 04-21-2011 |
| 20110089112 | METHOD AND DEVICE FOR THE REMOVAL OF PARTIALLY PROTEIN BOUND SUBSTANCES - A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis. | 04-21-2011 |
| 20110132841 | DIALYSIS SYSTEM INCLUDING MULTI-HEATER POWER COORDINATION - A dialysis system includes a first fluid heater, a second fluid heater, a supplemental power source and a logic implementer. The logic implementer is configured to use the supplemental power source such that when the first and second heaters are powered simultaneously, a collective current draw does not exceed a maximum allowable current draw of a branch power source powering the system | 06-09-2011 |
| 20110163033 | NOISE-REDUCING DIALYSIS SYSTEMS AND METHODS OF REDUCING NOISE IN DIALYSIS SYSTEMS - A dialysis system includes at least one pneumatic valve, a pneumatic pump in fluid communication with the pneumatic valve, a pneumatic line communicating with an inlet and an outlet of the pneumatic pump, a flow restrictor placed in the pneumatic line, and a logic implementer. The logic implementer is programmed to operate the pneumatic valve to either (i) communicate the pneumatic outlet with the pneumatic inlet of the pneumatic pump through the flow restrictor and the pneumatic line, or (ii) communicate the outlet of the pneumatic pump with a component of the dialysis system. | 07-07-2011 |
| 20110163034 | METHOD AND DEVICE TO EARLY PREDICT THE Kt/V PARAMETER IN KIDNEY SUBSTITUTION TREATMENTS - A method for determining or predicting the adequacy parameters that will be achieved at the end of a kidney substitution treatment during said kidney substitution treatment wherein the kidney substitution treatment is provided by a machine, which has an extracorporeal blood system pumping the patient blood through the blood chamber of a dialyzer, wherein the dialyzing fluid collects the waste products from the patient after flowing through the dialyzing fluid chamber of the dialyzer and wherein a device able to measure a adequacy parameter is coupled with the kidney substitution treatment machine and wherein the slope of a preferable linear guideline for the adequacy parameter is compared to the slope of the delivered adequacy parameter and if the slope of both are equal a linearization is performed to determine or predict the adequacy parameter at the end of the kidney substitution treatment. | 07-07-2011 |
| 20110186518 | POLYMER COMPOSITION WITH PHYTOCHEMICAL AND DIALYSIS MEMBRANE FORMED FROM THE POLYMER COMPOSITION - A biocompatible polymer composition which includes a matrix material and at least one of an isoflavone and a flavone at least partially dispersed in the matrix material is suited to use in a membrane for hemodialysis and other in vivo and in vitro applications. | 08-04-2011 |
| 20110233138 | POLYMER COMPOSITION AND DIALYSIS MEMBRANE FORMED FROM THE POLYMER COMPOSITION - A biocompatible polymer composition suited to forming a dialysis membrane includes a matrix material and at least one xanthone. The composition may be formed into a membrane for inserting into a dialyzer filter whereby free radicals in the fluid are removed by the membrane. | 09-29-2011 |
| 20110253629 | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use - The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid. | 10-20-2011 |
| 20120006748 | BUFFERED COMPOSITIONS FOR DIALYSIS - Dry acid-concentrate compositions comprising citrate and their use in preparing dialysate compositions and in performing hemodialysis is disclosed. | 01-12-2012 |
| 20120018377 | DIALYSATE REGENERATION SYSTEM FOR PORTABLE HUMAN DIALYSIS - A dialysate regeneration chamber is provided. In one embodiment, the dialysate regeneration chamber may include a toxin trap configured to selectively trap toxins and repel select cations. | 01-26-2012 |
| 20120018378 | RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONDUCTIVE AND CONVECTIVE CLEARANCE - A renal failure therapy method includes causing therapy fluid to flow to a renal failure therapy filter, directing at least twenty-five percent of the therapy fluid to the renal failure therapy filter to perform conductive clearance, and using the renal therapy failure filter to cause at least a substantial amount of the remaining therapy fluid to perform diffusive clearance. | 01-26-2012 |
| 20120031840 | METHOD FOR REDUCING AMYLOID BETA CONCENTRATION IN BLOOD - The present invention relates to a method for reducing a β-amyloid concentration in blood. Specifically, the present invention relates to a method for reducing a β-amyloid concentration in blood, comprising the steps of; removing blood out of a body, passing the blood that is removed through a hollow fiber membrane, and returning the blood that is passed through into the body, wherein the blood containing a β-amyloid-albumin complex is passed through the hollow fiber membrane to allow β-amyloid to adsorb to the hollow fiber membrane so that the β-amyloid concentration in blood is reduced. | 02-09-2012 |
| 20120031841 | Device and method for measuring a blood constituent in blood for an extracorporeal blood treating device - The invention relates to a device and a method for measuring a blood constituent in blood for an extracorporeal blood treatment device, comprising a dialyzer or a filter, and a hose line system comprising hose lines that are pervious to electromagnetic radiation. The kinetics of a liquid flowing at a measuring site in one of the hose lines of the hose line system is varied by varying the flow properties of the liquid in the hose line at the measuring site, particularly by stopping a blood pump arranged in the hose line and/or by closing a shut-off member in the hose line. The invention analyzes the intensity of the light entering the hose line at the measuring site and the light exiting the hose line at the measuring site. | 02-09-2012 |
| 20120061320 | APPARATUS AND METHOD FOR IDENTIFYING A TUBING SYSTEM FOR AN EXTRACORPOREAL BLOOD TREATMENT DEVICE - The invention relates to an apparatus for extracorporeal blood treatment, comprising a device for detecting a tubing system to be placed in the blood treatment apparatus and a method for detecting a tubing system to be placed in an extracorporeal blood treatment apparatus. The tubing system is detected on the basis of the dependency of the flow rate Q, at which the fluid is delivered by at least one pump of the extracorporeal blood treatment apparatus in a tubing section of the tubing system, on the speed n at which the at least one pump is operated, and on the inner diameter d of the tube of the tubing section. Because the dependency of the flow rate on the pump speed and the tube cross section is known, a conclusion can be drawn as to whether a particular tubing system has been placed in the extracorporeal blood treatment apparatus. | 03-15-2012 |
| 20120074062 | MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHODS FOR THEIR MANUFACTURE AND USE - The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc. | 03-29-2012 |
| 20120074063 | MEMBRANES HAVING IMPROVED PERFORMANCE - Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions. | 03-29-2012 |
| 20120074064 | MEMBRANES HAVING IMPROVED PERFORMANCE - Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, including improved sieving characteristics, providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions. | 03-29-2012 |
| 20120103902 | PERSONAL HEMODIALYSIS SYSTEM INCLUDING PRIMING SEQUENCE AND METHODS OF SAME - A dialysis machine includes a blood circuit, a dialysate circuit, and a dialyzer placed in communication with the blood circuit and the dialysate circuit. The dialysis machine includes a priming sequence in which dialysate is used to prime a first portion of the dialysate circuit and a physiologically compatible solution, other than dialysate, is used to prime a second portion of the dialysate circuit, the dialyzer and the blood circuit. | 05-03-2012 |
| 20120111795 | DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS - The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application. | 05-10-2012 |
| 20120138533 | DIALYSIS SYSTEM CONTROL SYSTEM WITH USER INTERFACE - Disclosed herein are systems and methods of using such systems including a dialysis system, a dialysis system controller operatively coupled to a filtration system, water purification system, dialysate preparation system and dialyzer system of the dialysis system, and a user interface communicatively coupled to the dialysis system controller. The user interface is configured to enable user interaction with the dialysis system and guide a user step-wise through set-up and shut-down of the dialysis system according to a pre-determined protocol. The user interface communicates with the dialysis system controller to activate an alarm condition when a deviation from the pre-determined protocol is sensed. | 06-07-2012 |
| 20120145631 | Perm Selective Asymmetric Hollow Fibre Membrane for the Separation of Toxic Mediators From Blood - A permselective asymmetric hollow fiber membrane for the separation of toxic mediators from blood, a process for the preparation of such a membrane, and the use of such a membrane in hemodialysis, hemodiafiltration, and hemofiltration for treatment of toxic mediator-related diseases. | 06-14-2012 |
| 20120152842 | METHOD AND SYSTEM FOR PROVIDING PRIMING AND RESTITUTION LIQUIDS FOR AN EXTRACORPOREAL BLOOD TREATMENT - A blood treatment system is primed with a replacement liquid that flows directly into the access line of the blood circuit. The replacement liquid may be replacement fluid or blood stored in the replacement bag or the pre-blood pump (PBP) bag. These replacement liquids from the replacement and PBP bags are also used during blood treatment. These replacement liquids are blood or a replacement fluid and, particularly, have electrolyte levels the same as or similar to the electrolyte levels in the vascular blood of the patient. | 06-21-2012 |
| 20120181230 | PRODUCTION OF INDIVIDUAL CONCENTRATE - The invention relates to the production of a concentrate for dialysis, the composition of which can be adapted individually to the respective needs of the patient. To do so, the special components required individually are added in the form of highly concentrated special concentrates with a volume of 10-500 mL to 3-10 liters of standard concentrate. The two solutions are then mixed thoroughly by compressed air, which is blown through the concentrate intake rod into the solution from a compressed air source in the dialysis machine. | 07-19-2012 |
| 20120181231 | Dialysis Systems and Related Methods - A dialysis machine that includes a valve body defining a pressure passage and a sealing cap disposed at a first end of the valve body such that the sealing cap closes off the pressure passage at the first end of the valve body. The sealing cap has a deformable area configured to deform outwardly away from the valve body when pressurized fluid is introduced into the pressure passage of the valve body. The sealing cap is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the pressure passage of the valve body, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough. | 07-19-2012 |
| 20120193289 | De-Airing Oxygenator for Treating Blood in an Extracorporeal Blood Circuit - An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator. | 08-02-2012 |
| 20120193290 | Method and device for controlling an extracorporeal blood treatment apparatus - A method and device for controlling an extracorporeal blood treatment apparatus, which can be operated as a hemodialysis apparatus, hemofiltration apparatus or hemodiafiltration apparatus, are disclosed. The method and device make provision, apart from balancing the fluids as a function of the weights of the containers, for the measurement of the weight reduction or increase of at least one of the containers in the time interval in which the pump assigned to the respective container performs a preset number of revolutions or pump strokes. The change in the weight of the container for a half or one pump revolution can be determined. The delivery rate of the respective pump is ascertained from the measured weight reduction or increase in the specific time interval, thereby permitting the precise determination of the actual delivery rate of one or more pumps. The actual delivery rates of all the pumps are preferably monitored. | 08-02-2012 |
| 20120199532 | SYSTEM FOR PREPARING A MEDICAL FLUID AND METHOD FOR PREPARING A MEDICAL FLUID - A concentrate container for preparing a medical fluid, preferably for preparing a dialysis solution, is provided, the concentrate container including at least two concentrate compartments, wherein at least one of the concentrate compartments has a medical fluid outlet, and at least one of the concentrate compartments has a diluent inlet. Further, systems for preparing a medical fluid and a method for preparing a medical fluid are described. | 08-09-2012 |
| 20120199533 | HEMODIALYSIS APPARATUS, METHOD OF OPERATING HEMODIALYSIS APPARATUS, AND WATER CONTENT REMOVAL SYSTEM - A hemodialysis apparatus includes a dialyzer, a quantitative vessel including a displaceable partition wall which partitions the inside of the quantitative vessel into a first chamber and a second chamber, a storage vessel which stores a dialysate, a dialysate exchange circuit which supplies the dialysate to the first chamber, and discharges a waste dialysate in the second chamber to the outside by the consequent displacement of the partition wall to the second chamber side, a dialysate supply circuit which supplies the dialysate in the first chamber to the dialyzer, and discharges the waste dialysate from the dialyzer to the second chamber by the displacement of the partition wall to the first chamber side, and a dialysate storage circuit which supplies the dialysate in the first chamber to the storage vessel by the displacement of the partition wall to the first chamber side. | 08-09-2012 |
| 20120205312 | SYSTEM AND METHOD FOR DETECTING ACCESS DISCONNECTION - A dialysis system includes: a blood filter; a dialysate pump connected to a dialysate portion of the blood filter; a blood pump connected to a blood portion of the blood filter, the blood pump including a diaphragm that is moved in cycles to pump the blood, the cycles having a flow period and a no-flow period; a patient access device in fluid communication with the blood portion of the blood filter, the no-flow period having a first characteristic of a property when the patient access device is lodged in a patient and a second characteristic of the property when the patient access device is dislodged from the patient; and a logic implementer configured to determine that the patient access device has been dislodged from the patient when the second characteristic of the parameter is detected. | 08-16-2012 |
| 20120211422 | APPARATUS AND METHOD FOR SUPPORTING AN OPERATOR IN OPERATING A MEDICAL DEVICE AS WELL AS SINGLE-USE ITEMS FOR A MEDICAL DEVICE - Apparatus for supporting an operator in operating a medical device, comprising a signaling device for signaling a necessary operation of a component to be operated of the medical device, preferably by emitting a signal from the component to be operated and/or by orienting a signal onto the component to be operated. Method for supporting an operator in operating a medical device, comprising the signaling of a necessary operation of a component to be operated of the medical device by emitting a signal from the component to be operated and/or by orienting a signal onto the component to be operated. Single-use item for a medical device, preferably a single-use item for the medical device, with a component to be operated by an operator, wherein the component to be operated comprises a signaling device for emitting an optical, acoustical, and/or haptical signal. | 08-23-2012 |
| 20120223015 | MECS DIALYZER METHOD - The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels. | 09-06-2012 |
| 20120223016 | DEVICE AND METHOD FOR DETECTING BLOOD OR BLOOD CONSTITUENTS IN THE LIQUID SYSTEM OF A DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT - The present invention relates to an apparatus for dialysis treatment which has device(s) for balancing fresh and used dialysis fluid. The present invention also relates to a method of balancing fresh and used dialysis fluid. The apparatus and method according to the present invention for balancing fresh and used dialysis fluid are characterized in that the individual balancing chambers of the balancing system receive both fresh dialysis fluid and used dialysis fluid, the functions of the balancing chambers being alternately interchanged. In this way, exact balancing can be achieved even when the volumes of the individual chambers differ from one another. Over the period of the treatment as a whole, the differences between the volumes balance each other out due to the cyclic interchange of the chambers. | 09-06-2012 |
| 20120228226 | KIDNEY SUBSTITUTION TREATMENT MACHINE - The invention relates to a method for normalizing, storing and/or displaying curves describing the adequacy of a kidney substitution treatment wherein the treatment is provided by a machine which has an extracorporeal blood system ( | 09-13-2012 |
| 20120248039 | DIALYSIS SYSTEM INCLUDING MULTI-HEATER POWER COORDINATION - A dialysis system includes a first fluid heater, a second fluid heater, a supplemental power source and a logic implementer. The logic implementer is configured to use the supplemental power source such that when the first and second heaters are powered simultaneously, a collective current draw does not exceed a maximum allowable current draw of a branch power source powering the system | 10-04-2012 |
| 20120298580 | METHOD FOR RINSING AND/OR FOR FILLING A BLOOD TREATMENT DEVICE AND BLOOD TREATMENT DEVICE - A method is provided for rinsing and/or filling a blood treatment device, in particular for priming such a device. The blood treatment device includes at least one membrane filter, in particular a hollow fiber membrane filter, at least one first partial circuit, and at least one second partial circuit, with the first and second partial circuit being separated by the membrane filter in a semipermeable manner. The first partial circuit is first filled with a fluid with a uniform and/or a pulsatile first volumetric flow rate that does not exceed a specified threshold value. At this value the fluid has not yet completely wetted and/or soaked the membrane, and/or the second partial circuit is at least temporarily open towards the atmosphere, and air is displaced from the first into the second partial circuit via the membrane filter, and/or during filling no negative pressure is applied to the first partial circuit. | 11-29-2012 |
| 20120298581 | DEVICE AND METHOD FOR DETECTING AN OPERATING STATE OF AN EXTRACORPOREAL BLOOD TREATMENT | 11-29-2012 |
| 20120305486 | HIGH CUT-OFF HEMODIALYSIS MEMBRANE FOR USE IN LIVER DIALYSIS - A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators. | 12-06-2012 |
| 20120318739 | METHOD FOR REGULATING THE SUPPLY OF SUBSTITUTING DURING EXTRACORPOREAL BLOOD TREATMENT AND EXTRACORPOREAL BLOOD TREATMENT DEVICE COMPRISING A UNIT FOR REGULATING THE SUPPLY OF SUBSTITUATE - The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete. | 12-20-2012 |
| 20120318740 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND METHOD OF OPERATION - Systems and methods for monitoring the presence of blood in an extracorporeal blood circuit are disclosed. A control unit, which is connected to a blood detector and to one or several pressure sensors, determines whether blood is present in the membrane device based on the differential pressure there over and generates a signal if the presence of blood as detected by the blood detector and the presence of blood as determined based on the differential pressure value do not coincide with each other. | 12-20-2012 |
| 20130001165 | SYSTEM FOR CARRYING OUT A BLOOD TREATMENT - The present invention relates to a system for the carrying out of a blood treatment, in particular a dialysis treatment, wherein the system has at least one blood treatment device, in particular a dialyzer, and at least one tank from which treatment fluid, in particular dialysis fluid, is removed during the carrying out of the blood treatment and/or into which consumed treatment fluid, in particular consumed dialysis fluid, is filled during the carrying out of the blood treatment, wherein the tank is an element of at least one mobile apparatus which can be connected to the blood treatment device such that at least one fluid connection can be established between the tank and the blood treatment device. | 01-03-2013 |
| 20130026098 | Device and method for monitoring the connection of a blood treatment unit to the fluid system of an extracorporeal blood treatment apparatus - A device and method for monitoring the connection of a blood treatment unit to a fluid system of an extracorporeal blood treatment apparatus are described, in which the blood treatment unit includes an inlet and an outlet for connection to the fluid system and the fluid system includes a line system with a first line segment connected to the inlet and a second line segment connected to the outlet. An extracorporeal blood treatment apparatus includes a device for monitoring the connection of the blood treatment unit to the fluid system. The device and method for monitoring the connection of the blood treatment unit to the fluid system is based on measurement of pressure in the fluid system of the blood treatment apparatus. Solely on the basis of the pressure measurement, it is ascertained whether the connection of the blood treatment unit to the fluid system is correct or incorrect. | 01-31-2013 |
| 20130032536 | HEMODIALYSIS SYSTEMS AND METHODS - Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments. | 02-07-2013 |
| 20130037485 | BLOOD TREATMENT SYSTEMS AND METHODS - Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments. | 02-14-2013 |
| 20130056418 | DIALYSATE FLOW CONTROL - Method and apparatus for controlling the dialysate flow in a dialysis device. A change of the value of a control factor, caused by a variation of a property of the dialysate or of the blood or by a change of the dialysate flow, is determined in order to control the dialysate flow. The control factor is a measure for the exchange of substances via the dialyzer and thus the effectiveness of the dialyzer. If the change of the value of the control factor exceeds a limit, the dialysate flow is increased. On the other hand, the dialysate flow is reduced if the change of the value of the control factor falls short of the limit range. | 03-07-2013 |
| 20130062283 | DEVICE FOR REGULATING AT LEAST ONE FILTRATION VALUE, HAEMODIALYSIS MACHINE AND CORRESPONDING METHOD AND USE - The present invention relates to an apparatus for the regulation of at least one filtration value in a machine for the treatment of a medical fluid, in particular in a blood treatment machine, having at least one centrifugal pumping means, to a hemodialysis machine and to a method and to a use therefor. | 03-14-2013 |
| 20130068690 | ADSORPTION DEVICES, SYSTEMS AND METHODS - Adsorption devices, systems, and methods are provided. In one embodiment, an adsorption device includes a fabric and an adsorbing complex attached at least partially attached to a surface of the fabric, the adsorbing complex being reactive to selectively adsorb a substance from a liquid passing through the fabric to remove at least a portion of the substance from the liquid. In one embodiment, the adsorption device can be incorporated into an extracorporeal blood circuit adapted to filter phosphate from blood of a hemodialysis patient without altering chemistry of the blood. | 03-21-2013 |
| 20130098838 | Method as well as apparatuses for retrograde filling of at least one calcium line of an extracorporeal blood circuit - The present invention relates to a method for priming a line for adding a medical solution, the line branching off a return line of an extracorporeal blood circuit, in particular a calcium line, a control device for controlling or regulating the method according to the present invention and a blood or plasma treatment apparatus with at least the control device according to the present invention. It further relates to a digital storage medium, a computer program product as well as a computer program. | 04-25-2013 |
| 20130112620 | VIBRATION-ASSISTED DIALYSIS METHOD - Disclosed herein are an apparatus and method of increasing dialysis dose and waste removal with the introduction of mechanical energy, such as vibration, to a hemodiafiltration membrane The method generally includes providing a dialyzer that includes a vibration element in engaged vibratory communication with a hemodiafiltration membrane The method also includes enabling extracorporeal flow of pre-dialyzed blood and a dialysate through the dialyzer and respectively past opposing surfaces of a vibrating hemodiafiltration membrane to achieve a solute clearance from the pre-dialyzed blood that is at least about 10% greater than a solute clearance from the pre-dialyzed blood obtained in the absence of the engaged vibratory communication Various apparatus are also disclosed, each of which includes a vibration element in vibratory communication with the dialyzer. | 05-09-2013 |
| 20130118979 | Dialysate Regeneration Unit - A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path. | 05-16-2013 |
| 20130186828 | METHOD FOR POWERING PORTABLE DIALYSIS MACHINE - A method for operating a medical fluid machine, the method comprising: (i) if alternating current (“AC”) power is available, charging a battery, if needed, and powering the medical fluid machine with the AC power; and (ii) if AC power is not available (a) if fuel cell power is available, charging the battery, if needed, and powering the medical fluid machine with the fuel cell power; and (b) if fuel cell power is not available, powering the medical fluid machine using battery power until the AC power or fuel cell power is available. | 07-25-2013 |
| 20130186829 | BUFFERED COMPOSITIONS FOR DIALYSIS - Acid concentrates, and dialysate compositions prepared therefrom, contain citric acid and an effective amount of a buffering agent selected from acetate and/or lactate. The buffering agent allows a physiologically acceptable amount of citrate to maintain the desired pH of the dialysate. | 07-25-2013 |
| 20130199998 | HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME - Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge. | 08-08-2013 |
| 20130206693 | APPARATUS AND METHOD FOR SUPPORTING AN OPERATOR IN OPERATING A MEDICAL DEVICE AS WELL AS A SINGLE-USE ITEMS FOR A MEDICAL DEVICE - The invention relates to an apparatus for supporting an operator in operating a medical device, comprising a signaling device ( | 08-15-2013 |
| 20130213890 | MODULAR HEMODIALYSIS SYSTEM - Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module. | 08-22-2013 |
| 20130213891 | METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES - A dialysis system comprising: a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication sorbent cartridge and the storage container; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer. | 08-22-2013 |
| 20130228516 | AMBULATORY ULTRAFILTRATION DEVICE, RELATED METHODS AND A COMPUTER PROGRAM PRODUCT - An ambulatory ultrafiltration device includes a blood filter that has a blood side or fluid communication with the vascular system of the subject, an ultrafiltrate side, and a semipermeable membrane disposed between the blood side and the ultrafiltrate side. The ambulatory ultrafiltration also includes a buffer vessel in fluid communication with the blood side of the blood filter, and a blood pump. The blood pump is controlled to alternate between a withdrawal phase and a return phase. In the withdrawal phase, blood is withdrawn on a blood path from the subject via the blood filter to the buffer vessel. In the return phase, blood is returned from the buffer vessel to the subject on the blood path. The blood filter is arranged to remove ultrafiltrate from the blood during at least one of the withdrawal and return phases. | 09-05-2013 |
| 20130228517 | DYNAMIC WEIGHT BALANCING OF FLOW IN KIDNEY FAILURE TREATMENT SYSTEMS - A kidney failure treatment system includes: (i) a dialysate supply; (ii) a weighing device; a control container coupled operably to the weighing device; (iii) a diffusion membrane; (iv) a drain; first and second pumps; (v) a first fluid conduit coupled fluidly to the dialysate supply and the diffusion membrane, the first fluid conduit coupled operably to the first pump; (vi) a second fluid conduit coupled fluidly to the control container and the drain, the second fluid conduit coupled operably to the first pump; and (vii) a third fluid conduit coupled fluidly to the diffusion membrane and the control conduit, the third fluid conduit coupled operably to the second pump. | 09-05-2013 |
| 20130233798 | BLOOD TREATMENT DEVICE - The present invention relates to a blood treatment device with at least one extra-corporeal blood circuit with a filter element and with at least one centrifugal pump means, wherein furthermore a monitoring means is provided, by means of which the flow resistance of the extracorporeal circuit can be determined, wherein the flow resistance can at least partly be determined with reference to the flow in at least one portion of the extracorporeal blood circuit and the speed of the centrifugal pump means. Furthermore, the present invention relates to a monitoring means for a blood treatment device and to a method for operating a blood treatment device. | 09-12-2013 |
| 20130240443 | METHOD FOR DOSING A SUBSTITUATE WHICH WAS PRODUCED BY A BLOOD TREATMENT APPARATUS AS WELL AS APPARATUSES - The present invention relates to methods for dosing a substituate produced by a blood treatment apparatus. Dosing for the present invention is via a hydraulic system of the blood treatment apparatus, the hydraulic system having at least one dialysis liquid supply line which leads into a dialyzer and at least one substituate line. Regulating or controlling the size of the share which passes through the second filtration stage is performed by affecting at least one conveying apparatus and/or at least one flow limitation device and/or a flow divider valve, which are each located or which each operate in the dialysis liquid supply line and/or the substituate line and/or in the branch line which connects the dialysis liquid supply line with the substituate line. The present invention further relates to a control device, a blood treatment apparatus, a medical functional apparatus, and a computer-readable storage medium related to the methods. | 09-19-2013 |
| 20130248448 | Citrate-Based Dialysate Chemical Formulations - The present invention constitutes dialysate formulations that are suitable for use in preparing dialysate solutions for use in batch and/or proportioning systems and for improving dialysis efficiency by reducing or preventing clotting of the dialysis flow paths. The dialysate chemical formulations for one batch of dialysate comprise an acid concentrate stored in a first vessel, and a citrate-containing bicarbonate concentrate stored in a second vessel. The contents of the first and second vessels are emptied into a dialysate preparation tank and mixed with water to form a batch quantity of dialysate solution. Alternately, a dry acid and/or a dry citrate-containing base concentrates are dissolved separately in measured quantities of water to form liquid concentrates which are then used in conjunction with a proportioning machine to generate on-line a final dialysis solution stream. | 09-26-2013 |
| 20130248449 | FLUID AND AIR HANDLING IN BLOOD AND DIALYSIS CIRCUITS - An air purging method includes: (a) detecting a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; (b) stopping a blood pump; (c) closing a venous patient line; (d) opening a blood circuit air vent valve and a drain valve; and (e) running the blood pump to meter air through the air vent valve and the drain valve to a drain. | 09-26-2013 |
| 20130277307 | BIOMIMETIC MEMBRANES AND USES THEREOF - A liquid membrane system is disclosed in the form of a biochannel containing bulk liquid membrane (BLM), biochannel containing emulsion liquid membrane (ELM), and biochannel containing supported (immobilised) liquid membrane (SLM), or a combination thereof, wherein said liquid membrane system is based on vesicles formed from amphiphilic compounds such as lipids forming a bilayer wherein biochannels have been incorporated and wherein said vesicles further contain a stabilising oil phase. The uses of the membrane system include water extraction from liquid aqueous media by forward osmosis, e.g. for desalination of salt water. | 10-24-2013 |
| 20130327713 | APPARATUS FOR EXTRA-CORPOREAL BLOOD TREATMENT AND METHOD OF PRESETTING AN INITIAL MODE OF TREATMENT FOR AN EXTRA-CORPOREAL BLOOD TREATMENT APPARATUS - An apparatus for extra-corporeal blood treatment and a method of presetting an initial mode of treatment in the opening phase of an extra-corporeal blood treatment are controlled based on the opening phase of a haemodiafiltration, in which particularly fast removal of electrolytes such as potassium or of urea occurs. The apparatus has a control and computing unit for presetting an initial mode of treatment, in which over a preset interval of time, substituate is fed to the extra-corporeal blood circuit, dialysis fluid is not fed through the dialyser and instead only ultrafiltrate is withdrawn from the dialyser and, on expiry of the preset interval of time, dialysis fluid is fed through the dialyser. Alternatively, dialysis fluid is provided during the preset interval of time through the dialyser at a dialysis fluid flow rate that is smaller than the dialysis fluid flow rate after the preset interval of time has elapsed. | 12-12-2013 |
| 20130334138 | DUAL, SINGLE NEEDLE BLOOD TREATMENT SYSTEM AND METHOD - A blood treatment system includes: (i) a dialysate circuit; (ii) a blood filter in fluid communication with the dialysate circuit; and (iii) an extracorporeal circuit in fluid communication with the blood filter, the extracorporeal circuit including a blood pump, a downstream line from the blood pump, an upstream line to the blood pump, a first patient access line, a second patient access line, a first valve arrangement fluidly communicating the first and second patient access lines to the downstream line, and a second valve arrangement fluidly communicating the first and second patient access lines to the upstream line. | 12-19-2013 |
| 20130341274 | MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS - A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed. | 12-26-2013 |
| 20140027380 | DIALYSIS SYSTEM HAVING AUTOIDENTIFICATION MECHANISM - A dialysis system is disclosed including an autoconnection mechanism. The autoconnection mechanism in an embodiment is configured such that (i) a tip protector remover is translated in a first direction towards a plurality of supply line connectors, (ii) the tip protector remover is locked to each of a plurality of supply line tip protectors connected to the plurality of supply line connectors, (iii) the tip protector remover is translated in a second direction away from the plurality of supply line connectors to remove the plurality of supply line tip protectors from the supply line connectors, the tip protector remover is translated in a third direction different from the first and second directions, and (v) solution line connectors are translated towards the supply line connectors to connect each of the solution line connectors to one of the supply line connectors. | 01-30-2014 |
| 20140042092 | THERAPY PREDICTION AND OPTIMIZATION OF SERUM POTASSIUM FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS - A method of predicting serum potassium concentrations in a patient during hemodialysis includes measuring serum potassium concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a potassium mobilization clearance and a pre-dialysis distribution volume of potassium for the patient. Serum potassium concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated potassium mobilization clearance and pre-dialysis distribution volume of potassium of the patient. | 02-13-2014 |
| 20140061132 | METHOD TO TREAT BLOOD BY CONTROLLING BLOOD PUMPS WITH FLUID PUMPS - A washer press apparatus for washing and dewatering a wide range of solids concentrations of pulp in liquid suspensions includes multiple distinct displacement wash zones about a drum with multiple nips. | 03-06-2014 |
| 20140083943 | Device and Method for Detecting the Recirculation During an Extracorporeal Blood Treatment - A device and method for detecting recirculation for an extracorporeal blood treatment apparatus and an apparatus with a device for detecting recirculation are based on targeted haemodilution by administration of a substituate bolus, causing a pressure change in venous and arterial branches of the extracorporeal circuit due to a viscosity change of flowing fluid. | 03-27-2014 |
| 20140083944 | WEIGHT-CONTROLLED SORBENT SYSTEM FOR HEMODIALYSIS - A hemodialysis system including (i) a dialyzer, (ii) a blood circuit including a blood pump in fluid communication with the dialyzer, (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate, (iv) a dialysate reservoir, (v) a reservoir pump in fluid communication with the dialysate circuit and the dialysate reservoir, (vi) a supply of concentrate for reconstituting dialysate in the dialysate circuit, and (vii) wherein the hemodialysis system is configured to electronically weigh the dialysate reservoir and the supply of concentrate. | 03-27-2014 |
| 20140110340 | TOTAL CHLORINE WATER DETECTION SYSTEM AND METHOD FOR MEDICAL FLUID TREATMENTS - A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing a KI/water sample chamber and a sodium sulfate chamber. A first electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the water sample. A second electrode pair in contact with fluid in the KI/water sample detects an amount of tri-iodide generated by the first electrode pair. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level. | 04-24-2014 |
| 20140197105 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane. | 07-17-2014 |
| 20140202958 | PORTABLE DIALYSIS DEVICE - A portable dialysis device that can be continuously worn in and/or on the body of a patient, with a blood chamber in which the patient's blood can be received, a hydraulic chamber which can be filled with a hydraulic fluid and which adjoins the blood chamber, an at least partially flexible delivery membrane which is arranged between the hydraulic chamber and the blood chamber and which, when the hydraulic chamber is filled with hydraulic fluid, is movable in the direction of the blood chamber in such a way as to cause a compression of the blood chamber and therefore an ejection of the blood located therein, a pump for controllable filling and/or emptying of the hydraulic fluid in the hydraulic chamber, such that blood can in this way be conveyed into the blood chamber and/or out of the latter, a filter membrane which is arranged between the blood chamber and the hydraulic chamber and through which waste substances in the blood can be removed to the hydraulic fluid located in the hydraulic chamber, such that the hydraulic fluid serves at the same time as dialysate. Additionally, a method for operating a portable dialysis device. | 07-24-2014 |
| 20140217027 | SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL - Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end. | 08-07-2014 |
| 20140217028 | SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION - A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance. | 08-07-2014 |
| 20140263062 | Universal portable machine for online hemodiafiltration using regenerated dialysate - Manifolds suitable for use in hemodialysis, hemofiltration, hemodiafiltration, and peritoneal dialysis are provided. One or more of the manifolds can include a manifold body and an external tube. The manifold body can include at least one conduit including a first conduit and at least one port including a first port in fluid communication with the first conduit. The external tube can be in fluid communication with the first port and can include a main segment, a first branch segment, and a second branch segment containing at least one bacterial filter. The first branch segment and/or second branch segment can include at least one flow restrictor. Dialysis machines, systems, and kits including one or more such manifold are also provided, as are methods of performing hemodiafiltration using such manifolds. | 09-18-2014 |
| 20140291243 | DIALYSIS SYSTEM WITH ULTRAFILTRATION CONTROL - Systems and methods are disclosed for performing hemodialysis that include fluid handling systems that provide accurate control over the type and level of hemodialysis being performed. The system includes a first pump for pumping dialysate into a dialyzer and a second pump for pumping dialysate out of the dialyzer. The system also includes a third pump that provides improved control of a level of ultrafiltration, hemodiafiltration, or both. | 10-02-2014 |
| 20140299544 | BLOOD TREATMENT SYSTEMS AND METHODS - The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. According to one aspect, a blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus, the blood pump comprising a pneumatically actuated or controlled reciprocating diaphragm pump. In an embodiment, the diaphragm of the pump comprises a flexible membrane formed or molded to generally conform to a curved inner wall of a pumping chamber or control chamber of the pump, wherein the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump. In another aspect, a system for monitoring the adequacy of blood flow in a blood line of the hemodialysis apparatus allows a controller to suspend dialysate pumping operations if the adequacy of blood flow in the blood line is sub-optimal, and to present information on a display on the quality of blood flow in the blood line. | 10-09-2014 |
| 20140299545 | DIALYSIS SYSTEM - A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. | 10-09-2014 |
| 20140374353 | Vial Spiking Assemblies and Related Methods - This disclosure relates to vial spiking assemblies and related methods. In certain aspects, the vial spiking assemblies include a vial adapter having a base, a spike extending from a central region of the base, and a sidewall extending from the base and surrounding the spike. The base and the sidewalls partially, define a cavity that is configured to receive at least a portion of the vial. The assemblies also include a spike cover that is removably attached to the spike and that includes a material configured to indicate when the material is contacted with liquid. | 12-25-2014 |
| 20150008183 | SENSOR AND METHOD OF SENSING FOR DIALYSIS MACHINE - A dialysis machine useful in hemodialysis can process or treat a reverse osmosis water flow received through the machine to prepare a dialysate. The machine can include an additive source to introduce an additive, such as bicarbonate, to the reverse osmosis water flow. The machine can include a sensor in fluid communication with the additive introduction point that can measure the conductivity or similar characteristic of the solution. During a first time period when additive is actively introduced to the reverse omosis water flow, the sensor can measure a relatively high conductivity value. During a second time period when additive is not introduced to the reverse osmosis water flow, the sensor can measure a relatively low conductivity value. The dialysis machine can include a controller that processes these measurements to assist control and operation of the machine. | 01-08-2015 |
| 20150014249 | METHOD OF CONTROLLING MEDICAL FLUID THERAPY MACHINE BRIGHTNESS - A method of controlling a medical fluid therapy machine display brightness includes: performing a medical fluid therapy using the medical fluid therapy machine, the medical fluid therapy machine including a display; sensing an amount of ambient light impinging the display without receiving light directly from the display; controlling a level of backlight brightness for the display based on the amount of ambient light sensed; and displaying information relating to the medical fluid therapy on the display using the controlled level of backlight brightness. | 01-15-2015 |
| 20150027951 | Dialysis Machine - The invention relates to a dialysis machine having improved flow balance. In particular, the invention monitors the pressure of blood entering and leaving a patient's body using several sensors ( | 01-29-2015 |
| 20150034557 | APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR DELIVERY OR COLLECTION OF FLUIDS - An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit ( | 02-05-2015 |
| 20150076066 | BIOREACTOR UNIT FOR USE IN BIOARTIFICIAL KIDNEY DEVICE - There is provided a bioreactor device having cells, including human primary proximal tubule cells (HPTCs) or HPTC-like cells on the exterior surface of hollow fiber membranes included within the device. Also provided are bioartificial kidney devices incorporate the bioreactor device and methods of using such devices. | 03-19-2015 |
| 20150076067 | MICROFLUIDIC ORGAN ASSIST DEVICE INCORPORATING BOUNDARY LAYER DISRUPTERS - The general disclosure discusses a system and method for improving the efficacy of blood filtration treatments such as hemodialysis, hemofiltration, and hemodiafiltration. More particularly, the disclosure discusses a microfluidic device that includes first and second channels separated by a permeable membrane. One of the channels is configured for blood flow and includes a protein gel disruption layer. The protein gel disruption layer includes a plurality of elements at least partially extending across the blood flow channel that reduce the formation of a boundary layer or gel layer at the blood-membrane interface. | 03-19-2015 |
| 20150083664 | HIGH CITRATE DIALYSATE AND USES THEREOF - The dose of dialysis in terms of urea clearance is marginal in many hemodialysis patients, and metabolic acidosis as determined by the pre-dialysis serum HCO | 03-26-2015 |
| 20150129497 | CARTRIDGE AND METHOD FOR INCREASING MYOCARDIAL FUNCTION - The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure. | 05-14-2015 |
| 20150129498 | HEMODIALYSIS APPARATUS OPERATING METHOD AND HEMODIALYSIS APPARATUS - A hemodialysis apparatus | 05-14-2015 |
| 20150144558 | SLOW DIALYSATE ADAPTOR APPARATUS FOR INTERMITTENT HEMODIALYSIS - A system and method for providing slow dialysate flow with an intermittent hemodialysis delivery (IHD) system are disclosed. The system includes a dialysate slow-flow fluid pump having an outlet for connection to an inlet port of a hemodialyzer and an inlet for connection to a dialysate bulk flow line in association with the IHD. The system further includes an outlet line for coupling an outlet port of the hemodialyzer back to the dialysate bulk flow line, wherein the dialysate slow-flow fluid pump is configured to control the rate of delivery of dialysate to the hemodialyzer. | 05-28-2015 |
| 20150290381 | METHODS AND APPARATUS FOR KIDNEY DIALYSIS AND EXTRACORPOREAL DETOXIFICATION - The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification. | 10-15-2015 |
| 20150343127 | MULTI-PASS DIALYSIS - A system for dialysis is disclosed. The system includes a dialyzer having dialysis fluid inlet and outlet ports, a blood pump connected to the dialyzer for pumping blood from a patient, at least one drip chamber in series with the dialyzer, a source of fresh dialysis fluid in series with the dialysis fluid inlet port, a pump connected with the source of the fresh dialysis fluid, and at least one of a balance chamber or a flow channel between the dialysis fluid outlet port and the dialysis fluid inlet port for balancing a flow of fresh dialysis fluid and spent dialysis fluid to the dialysis fluid inlet port. A number of passes of spent dialysis fluid through the dialyzer is set by a ratio of a flow of spent dialysis fluid within the dialyzer to a flow of fresh dialysis fluid to the dialyzer. | 12-03-2015 |
| 20150367062 | FLUID CIRCUIT PRIMING METHODS, DEVICES, AND SYSTEMS - According to embodiments, priming systems, methods, and devices are disclosed which allow medical treatment devices which pump fluid to be primed with minimal operator intervention and a high level of convenience. A blood circuit with a filter fitted with one or more air vents on a non-blood compartment is attached to a treatment system and priming fluid pumped slowly through the blood circuit in a loop. The source of fluid may be elevated, or the pumping may generate pressure, such that priming fluid is forced through the membrane of the filter and out the air vent(s). In embodiments, the vents are hydrophobic which prevent fluid from being ejected, so the priming system can nm without intervention. | 12-24-2015 |
| 20160022894 | IMPROVED DIALYZER HOLDER AND IMPROVED AIRLESS BLOODLINE PRIMING METHOD - The present invention relates to a dialyzer holder to attach a dialyzer to a dialysis machine. During priming of a bloodline prior to a dialysis treatment, the dialyzer holder grips a dialyzer in approximately the center of the dialyzer, but allows movements of the dialyzer in an arc motion using two axes of rotation. The holder enables the dialyzer to move to a position where air can be primed from the dialyzer and, because the dialyzer can move toward the dialysis machine, this motion eliminates stress on the tubing connected to the bottom and top of the dialyzer and reduces the length of bloodline tubing necessary to accommodate dialyzer movement. The dialyzer holder incorporates an attachment point for a venous chamber for use during the priming procedure, enabling the venous chamber to move with the dialyzer, further reducing the tubing between the dialyzer and the venous chamber. | 01-28-2016 |
| 20160030653 | INTEGRATED WATER TESTING SYSTEM AND METHOD FOR ULTRA-LOW TOTAL CHLORINE DETECTION - A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing an iodide/water sample chamber and a reducing agent chamber. An electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the dialysis water. The electrode pair detects the amount of tri-iodide generated in proportion to the amount of active chloride in the dialysis water. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level. | 02-04-2016 |
| 20160030657 | DIALYSIS SYSTEM WITH BALANCE CHAMBER PRIME AND RINSEBACK - A dialysis system includes an extracorporeal circuit, a dialysis fluid circuit including first and second balance chambers, a fresh dialysis fluid pump in fluid communication with first and second fresh compartments of the first and second balance chambers, respectively. The first and second fresh compartments are in fluid communication with a fresh dialysate fluid inlet of the dialyzer, and a used dialysis fluid pump is in fluid communication with first and second spent compartments of the first and second balance chambers, respectively. The system is configured to run a blood rinseback sequence in which (i) at least one of the fresh used dialysis fluid pumps is operated to pump dialysis fluid through the dialyzer and into the extracorporeal circuit and (ii) the blood pump is operated to push blood back to a patient connected to the extracorporeal circuit. | 02-04-2016 |
| 20160038666 | HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME - Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge. | 02-11-2016 |
| 20160045655 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets. | 02-18-2016 |
| 20160058932 | HEMODIALYSIS AND HEMOFILTRATION MEMBRANES BASED UPON A TWO-DIMENSIONAL MEMBRANE MATERIAL AND METHODS EMPLOYING SAME - Perforated graphene and other perforated two-dimensional materials can be used in hemodialysis membranes and blood filtration membranes for selective removal of components from blood in vivo and ex vivo. The membranes are useful in hemodialysis and hemofiltration techniques to provide improved patient care. Hemodialysis systems can include a hemodialysis membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Hemofiltration systems can include one or more and preferably two or more blood filtration membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Methods for performing hemodialysis can involve exposing blood from a patient to a hemodialysis membrane formed from a perforated two-dimensional material. Ex vivo dialysis techniques can be performed similarly. Methods for filtration of blood can involve passing blood through one or more filter membranes or through a plurality of sequential filter membranes. | 03-03-2016 |
| 20160067280 | INTRADIALYTIC ADMINISTRATION OF SODIUM THIOSULFATE - The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the bool of toxic and metabolic waste in the patients undergoing hemodialysis, peritoneal dialysis, or gastro-intestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. In the method of the invention, dialysis solution components contain therapeutic amounts of sodium thiosulfate, which when fully reconstituted for use as a single solution, deliver 20-130 mg/dl of dialysate. | 03-10-2016 |
| 20160106903 | Fluid Pump Systems, and Related Methods for Pumping Biological Fluids - The present invention relates to a fluid pump system ( | 04-21-2016 |
| 20160151554 | RELATIVE PUMP CALIBRATION FOR ULTRAFILTRATION CONTROL IN A DIALYSIS APPARATUS | 06-02-2016 |
| 20160166748 | SENSING AND STORAGE SYSTEM FOR FLUID BALANCE | 06-16-2016 |
| 20160175507 | Extra-Corporeal Blood Treatment Device and Method for Switching Off or Reducing the Speed of A Non-Occluding Pump in A Fluid System of an Extra-Corporeal Blood Device | 06-23-2016 |
| 20160250406 | METHOD TO CONTROL A BLOOD TREATMENT APPARATUS AND DEVICES AFTER THE CONCLUSION OF TREATMENT | 09-01-2016 |
| 20170232179 | METHOD OF PURGING GAS BUBBLES IN AN EXTRACORPOREAL BLOOD CIRCUIT | 08-17-2017 |
