Entries |
Document | Title | Date |
20080197025 | Ionic based sensing for identifying genomic sequence variations and detecting mismatch base pairs, such as single nucleotide polymorphisms - Ionic interactions are monitored to detect hybridization. The measurement may be done measuring the potential change in the solution with the ion sensitive electrode (which may be the conducting polymer (e.g., polyaniline) itself), without applying any external energy during the binding. The double helix formation during the complimentary hybridization makes this electrode act as an ion selective electrode—the nucleotide hydrogen bonding is specific and thus monitoring the ionic phosphate group addition becomes selective. Polyaniline on the surface of nylon film forms a positively charged polymer film. Thiol linkage can be utilized for polyaniline modification and thiol-modified single strand oligonucleotide chains can be added to polyaniline. The sensitivity is because the double helix formation during the complimentary hybridization makes this electrode act as an ion selective electrode as the nucleotide hydrogen bonding is specific and thus monitoring the ionic phosphate group addition becomes selective. | 08-21-2008 |
20080251393 | ELECTROCHEMICAL SENSOR, KIT COMPRISING SAID SENSOR AND PROCESS FOR THE PRODUCTION THEREOF - The present invention relates to an electrochemical sensor for the detection of biological molecules and a process for the production thereof. In the sensor, an electrode system comprising at least one working electrode ( | 10-16-2008 |
20090000962 | Gene Detection Method, and Intercalator - A gene detection method for detecting a gene having a specific sequence with high sensitivity is provided. The gene detection method comprises a double-stranded nucleic acid formation step of forming double-stranded nucleic acid by hybridizing a nucleic acid probe immobilized on an electrode and a gene sample; a step of adding an intercalator which comprises a compound having a double-stranded nucleic acid binding site Ia that is specifically intercalated into the double-stranded nucleic acid and is covalently bonded to the double-stranded nucleic acid by light irradiation, an electrochemical active site Fa having electrochemical activity, and a connecting site La for connecting the double-stranded nucleic acid binding site Ia and the electrochemical active site Fa, and has an substitution group comprising one of compounds represented by -Lb-Ib and -Lc-Fb or a combination of the both compounds, at each of the respective sites; a light irradiation step of covalently bonding the double-stranded nucleic acid and the intercalator; and a detection step of detecting the intercalator covalently bonded to the double-stranded nucleic acid by electrochemical measurement. | 01-01-2009 |
20090120809 | Nitroreductase biosensors for detecting nitro-compounds - This invention provides a sensing device comprising an electrode comprising a noble metal layer, on which layer is located a biological material having nitroreductase activity. This invention further provides a method of detecting nitro group containing compounds, the method comprising the steps of:
| 05-14-2009 |
20090145776 | PENICILLIN G BIOSENSOR, SYSTEMS COMPRISING THE SAME, AND MEASUREMENT USING THE SYSTEMS - A penicillin G biosensor, systems comprising the same, and measurement using the systems. The penicillin G biosensor has an extended gate field effect transistor (EGFET) structure and comprises a metal oxide semiconductor field effect transistor (MOSFET) on a semiconductor substrate, a sensing unit comprising a substrate, a tin oxide film on the substrate, and a penicillin G acylase film immobilized on the tin oxide film, and a conductive wire connecting the MOSFET and the sensing unit. | 06-11-2009 |
20090272655 | METHOD FOR CHARACTERISATION OF THE QUALITY OF SIALOGLYCOPROTEINS VIA AN ISOFORM NUMBER I - A method is described for characterisation of the quality of a sialoglycoprotein via its isoform number I which is calculated from the isoform distribution of the capillary electrophoretic analysis of the sialoglycoprotein and represents a quality feature for the batch consistency, storage stability, biological half-life and the biological effectiveness of a therapeutic glycoprotein. Uses of this method are also described. | 11-05-2009 |
20090294303 | method for identifying compounds that affect a transport of a protein through menbrane trafficking pathway - Resistive-sensors are provided wherein networks or nanoframeworks of conducting polymer nanowires are electrochemically grown from pre-polymer solutions in the junction gap located between electrode pairs. | 12-03-2009 |
20090301900 | METHOD FOR MEASURING PROTEIN - The present claimed invention is to provide a method for measuring a protein that enables to detect the protein with high accuracy and high sensitivity through an electrochemical method at a high speed with a simple operation using a simple device. With the method, a working electrode | 12-10-2009 |
20100000881 | Electrochemical detection of nucleic acid hybridization - A nucleic acid hybridization detection assay is carried out at an electrode. A solid electrode, such as an indium tin oxide electrode, is modified by capture probes comprising single-stranded oligonucleotides immobilized to the surface of the electrode. In some embodiments using sandwich assay methodology, the capture probes hybridize complementary target nucleic acid sequences, which in turn are bound to detection probes comprising nanoparticle-oligonucleotide conjugates comprising target-complementary oligonucleotides. In some embodiments, detection probes comprise nanoparticles attached to molecules comprising one partner of a ligand-binding pair (e.g., streptavidin), while target sequences comprise the other partner of the ligand-binding pair (e.g., biotin). When the assay is carried out in the presence of a redox mediator, redox reactions catalyzed, and/or facilitated and/or enhanced by the presence of nanoparticles generate electrons that are transferred to the electrode, resulting in a detectable electrical signal. | 01-07-2010 |
20100006453 | Detection System - A method for detecting a target nucleic acid sequence in a sample, by subjecting it to an amplification | 01-14-2010 |
20100140112 | Nanoparticle Marker, Diagnostic Methods Using the Same and Diagnostic Kit and Apparatus Using the Same - A diagnostic kit disclosed herein comprises a nanoparticle-biomaterial complex, an extraction solution, a collection electrode, and a current peak measurement unit. The nanoparticle-biomaterial complex comprises: one or more nanoparticles selected from a metal group consisting of zinc, cadmium, lead, copper, gallium, arsenic, thallium, nickel, manganese and bismuth; one or more biomaterial-binding materials binding to the nanoparticles through a binding-stabilizing agent and binding specifically to the biomaterials to be detected; and a binding-stabilizing agent forming bonds between the nanoparticles and the biomaterial-binding materials. The extraction solution serves to isolate and extract the nanoparticles from the nanoparticle-biomaterial complex. The collection electrode serves to collect the nanoparticles from the extraction solution. The current peak measurement unit serves to measure current peaks corresponding to the nanoparticles collected from the collection electrode. A diagnostic kit disclosed herein comprises a nanoparticle-biomaterial complex, an extraction solution, a collection electrode and a current peak measurement unit. The nanoparticle-biomaterial complex comprises in the diagnostic kit: one or more nanoparticles selected from a metal group consisting of zinc, cadmium, lead, copper, gallium, arsenic, thallium, nickel, manganese and bismuth; one or more biomaterial-binding materials binding to the nanoparticles through a binding-stabilizing agent and binding specifically to the biomaterials to be detected; and a binding-stabilizing agent inducing the binding between the nanoparticles and the biomaterial-binding materials. The extraction solution serves to isolate and extract the nanoparticles from the nanoparticle-biomaterial complex. The collection electrode serves to collect the nanoparticles from the extraction solution. The current peak measurement unit serves to measure current peaks corresponding to the nanoparticles collected from the collection electrode. A diagnostic device disclosed herein is an information technology-integrated, miniaturized electrochemical biosensor, which comprises a disposable tip, an electrode, a container for storing a diagnostic reagent, and a unit for performing electric measurement or optical measurement, is in the form of a pipette or syringe, and has a container stopper in which the electrode is included. | 06-10-2010 |
20100236942 | METHOD FOR ELECTROCHEMICAL DETECTION OF NUCLEIC ACID SEQUENCES - The present invention relates to a new compound derived from ruthenium, of formula (I), known as pentaamin ruthenium [3-(2-phenanthren-9-yl-vinyl)pyridine] complex, as well as the use thereof as an electrochemical indicator of hybridization in a method for the detection of hybridization between nucleic acid sequences, for the quantification of said sequences, as well as the detection of the presence of a mismatched base and the position thereof within a nucleic acid sequence. | 09-23-2010 |
20100282617 | METHODS AND APPARATUS FOR DETECTING MOLECULAR INTERACTIONS USING FET ARRAYS - Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. | 11-11-2010 |
20100282618 | AMMONIA GAS SENSORS WITH VANADIUM-BASED SENSING ELECTRODE - An ammonia gas sensor is disclosed that includes a reference electrode, an ammonia selective sensing electrode and an electrolyte disposed therebetween. The ammonia sensing electrode comprises vanadium silicide, vanadium oxysilicide, vanadium carbide, vanadium oxycarbide, vanadium nitride, or vanadium oxynitride. | 11-11-2010 |
20100282619 | AMMONIA GAS SENSORS WITH LANTHANIDE VANADATE SENSING ELECTRODE - An ammonia gas sensor is disclosed that includes a reference electrode, an ammonia selective sensing electrode and an electrolyte disposed therebetween. The ammonia sensing electrode comprises an oxide material characterized by the formula | 11-11-2010 |
20100288651 | MULTI-WALLED CARBON NANOTUBE SENSOR COMPRISING INTERCALATING SPECIES AND METHOD OF DETECTION - There is provided a method of detecting an analyte in a sample, which comprises the steps of contacting the sample with a working electrode in the presence of an electrolyte and determining the electrochemical response of the working electrode to the sample, wherein the working electrode comprises a multi-walled carbon nanotube (MWCNT) and wherein detection takes place in the presence of a species which is capable of forming an intercalation compound with a carbon host material. Electrochemical sensors and compositions suitable for use in said method are also provided. | 11-18-2010 |
20100320096 | BIOMOLECULES DETECTION METHOD AND BIOMOLECULES DETECTION CHIP - A biomolecules detection method which detects a detection target biomolecule by a measurement of an electrochemical response, the method including: a standard solution measurement process which measures an electrochemical response of a standard solution which includes an electrochemically reactive agent having a direct or indirect binding capacity to the detection target biomolecule; sample solution measurement process which measures the electrochemical response of a sample solution, the sample solution containing, a sample material containing the detection target biomolecule, and the electrochemically reactive agent; a comparison process which compares an electrochemical response measurement result of the standard solution and an electrochemical response measurement result of the sample solution, and thereby obtains a comparison result; and a biomolecules content information detection process which, based on the comparison result, detects a content information of the detection target biomolecule in the sample solution. | 12-23-2010 |
20110180425 | Devices and methods for biochip multiplexing - The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples. | 07-28-2011 |
20110247945 | POTENTIOMETRIC SENSORS BASED ON ANIONIC BORON CLUSTERS - Potentiometric sensor comprising an ion selective electrode and the latter, on its part, containing a membrane characterized in that it comprises: a thermoplastic material; an electroactive substance based on a salt wherein the cation is the protonated form of the analyte to be determined and the anion is a cluster which comprises boron atoms; and a plasticizing agent. In addition, the invention further relates to the use of said sensor for the detection and/or quantification of a compound containing at least one nitrogen atom. | 10-13-2011 |
20110290671 | ELECTROCHEMICAL GAS SENSOR - An electrochemical gas sensor for detecting hydrocyanic acid in a gas sample has a measuring electrode ( | 12-01-2011 |
20110303555 | Method for detection of cyanide in water - The method for detection of cyanide in water is a method for the detection of a highly toxic pollutant, cyanide, in water using ZnO | 12-15-2011 |
20120037515 | IMPEDIMETRIC SENSORS USING DIELECTRIC NANOPARTICLES - A method for electrochemical impedance spectroscopy uses interdigitated electrodes functionalized with a first species and nanoparticles functionalized with a second species that preferentially attaches to the first species. The nanoparticles are composed of a material with a dielectric constant (k value) greater than 2. The chemically functionalized electrodes are then exposed to a solution containing the chemically functionalized nanoparticles which then become immobilized on the electrodes through the attachment of the first species to the second species. The impedance spectrum is measured and an amount of the first species is then determined from the measured spectrum. Because the high-k dielectric nanoparticles increase the double-layer capacitive impedance, the sensitivity of determining the amount of the first species attached to the second species is enhanced. | 02-16-2012 |
20120055813 | Methods and Apparatus for Measuring Analytes Using Large Scale FET Arrays - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 03-08-2012 |
20120061255 | Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays - Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. | 03-15-2012 |
20120061256 | Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays - Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. | 03-15-2012 |
20120132543 | METHOD OF ELECTROCHEMICALLY DETECTING A SAMPLE SUBSTANCE - A sample substance S is captured by a capture substance | 05-31-2012 |
20120186998 | Microelectrode, Microelectrode formation, and methods of utilizing microelectrodes for charaterizing properties of localized environments and substrates - Microelectrodes, microelectrode formation, and methods of utilizing microelectrodes for characterizing properties of localized environments and substrates are provided. A microelectrode can include a tungsten wire comprising a shaft and a conical tip. The conical tip can include an electroactive area. Further, the microelectrode can include an electroactive coating layer covering one or more surface of the tungsten wire. The tungsten wire surfaces can include a surface of the conical tip. An insulating layer can at least partially cover the shaft. | 07-26-2012 |
20120186999 | ELECTROCHEMICAL SENSOR - The invention provides an electrochemical sensor comprising an electrode assembly which comprises at least two electrodes, one of the electrodes comprising a metal species capable of catalysing the oxidation of hydrogen and/or methane. The sensor may be used in the detection and quantification of hydrogen and/or methane in exhaled breath, for example as a means of diagnosing lactose malabsorption or lactose intolerance. | 07-26-2012 |
20120217172 | METHOD FOR PROPORTIONING NITRATES AND/OR NITRITES IN A NEUTRAL MEDIUM - The present invention relates to a method for proportioning nitrate and/or nitrite ions in a solution using a copper electrode, said method being characterized in that it is carried out in constant potential mode and moreover in that it includes the steps of: i. applying a first potential to the copper electrode so as to reduce the copper oxides present on the surface of the metal copper electrode; ii. applying a second potential to the copper electrode so as to oxidize the metal copper formed in Step i into cupric ions; iii. applying a third potential to the copper electrode so as to reduce the copper oxides possibly formed in Step ii. Steps i through iii being carried out in a support electrolyte; and iv. proportioning the nitrate and/or nitrite ions of a solution to be analyzed by means of immersing the copper electrode, obtained in Step iii, in said solution to be analyzed while applying a fourth potential to the copper electrode so as to reduce the nitrate and/or nitrite ions, the support electrolyte of Steps i through iii, and the solution to be analyzed in Step iv, having a substantially neutral pH. | 08-30-2012 |
20120247977 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates. | 10-04-2012 |
20120267258 | METHOD FOR ELECTROCHEMICALLY DETECTING ANALYTE - In order to provide a method for electrochemically detecting an analyte which can detect an analyte with high detection sensitivity, when detecting an analyte S trapped on a working electrode, a label binding substance | 10-25-2012 |
20120292203 | VOLTAMMETRIC TECHNIQUE TO DETERMINE THE INDIVIDUAL CONCENTRATION OF DIFFERENT ANTIOXIDANTS OF THE SAME CLASS - Disclosed in certain embodiments is a method of determining the individual concentration of different antioxidants of the same class in a sample comprising contacting the sample with an effective amount of phenol; and analyzing the sample by voltammetry. | 11-22-2012 |
20120325681 | VERSATILE ELECTROCHEMICAL PAPER-IMMUNOSENSOR AND METHOD FOR DETECTION OF AMINOGLYCOSIDE ANTIBIOTICS BY USING THE SENSOR - An electrochemical paper-immunosensor and method for detecting aminoglycoside antibiotics is developed in the present invention. Single-walled carbon nanotubes are coated on the common filtration paper by dip-dry cycles. With antibody against neomycin adding to the coating solution, a high sensitive biosensor for specific detection of neomycin is prepared, satisfying to the rigid authority regulations. The sensor is not only sensitive but also rapid, comparing with the classic ELISA method, with LOD of 0.04 ng mL | 12-27-2012 |
20120325682 | LAYERED ELECTROCATALYST FOR OXIDATION OF AMMONIA AND ETHANOL - A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst. | 12-27-2012 |
20130037423 | Multi-Point Cellular Analysis - Provided are devices and methods for performing multi-point analysis on biological materials, such as cells. In one embodiment, the devices simultaneously collect information related to a characteristic of a cell membrane and a characteristic of the interior of the cell. | 02-14-2013 |
20130037424 | ELECTROLYTIC CELLS AND METHODS FOR THE PRODUCTION OF AMMONIA AND HYDROGEN - A method using an electrolytic cell to electrolyze urea to produce at least one of H | 02-14-2013 |
20130062221 | DISPOSABLE SENSOR FOR ELECTROCHEMICAL DETECTION OF HEMOGLOBIN - A disposable biosensor for determining the content of hemoglobin and hematocrit in a sample of whole blood that includes a laminated strip with a first and second end, at least a reference, a working electrode and a blank electrode embedded in the laminated strip. The working electrode contains a reagent sensitive to hemoglobin or hemotocrit. The blank electrode is used to measure oxidizable species in the fluid sample and to correct the current signal of the working electrode. The construction of the biosensor allows accurate measurement of the impedance of a small fluid sample, which is used to further correct the current signal of the working electrode. | 03-14-2013 |
20130068632 | METHODS AND APPARATUS FOR NANOMEMBRANE-BASED NUCLEIC ACID SENSING PLATFORM FOR PORTABLE DIAGNOSTICS - A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule. A voltammeter is provided to measure the electrical current or potential across the nanomembrane, and detect a change in the measured electrical current or potential to quantify the presence of the macromolecule | 03-21-2013 |
20130087467 | HIGH-PERFORMANCE ANALYTICAL INSTRUMENT AND METHOD - Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved Electrochemiluminescence (ECL) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications. The ECL apparatus comprises a 96 or more-well plate, where a microarray of working electrodes is placed in each well for high throughput and multi-analyte testing. The microarray of working electrodes connects with a counter electrode forming a two-electrode electrochemical system. Each well is electrically addressable, thereby controlling ECL reactions in flexible modes. The ECL apparatus further comprises a detector of ECL signals, and the detector employs a CCD-chip assembling matrix. Also provided are methods for high-throughput multi-analyte testing. The methods according to this disclosure are applied in various embodiments to test a broad range of analytes, including chemical compounds, proteins, peptides, DNAs, RNAs, antigens, antibodies, pathogens, contaminants, and derivatives thereof. | 04-11-2013 |
20130098779 | Detection of Phenols - According to the present invention, phenols may be detected using an electrochemical sensor comprising a first compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrode to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, a cannabinoid or a catechin compound. | 04-25-2013 |
20130105333 | Binary Metallic Alloys for Electro Oxidation in Alkaline Media and Method of Making Same | 05-02-2013 |
20130146479 | ANALYTICAL APPARATUS COMPRISING AN ELECTROCHEMICAL FLOW CELL AND A STRUCTURE ELUCIDATION SPECTROMETER - An apparatus is disclosed comprising: a sample conduit; an electrochemical flow cell; a source of carrier fluid; a structure elucidation spectrometer; a conduit and an in-line sample reservoir, such that: (a) a first operating modus wherein the sample conduit is connected to the conduit via the electrochemical flow cell and the in-line sample reservoir, and the source of carrier fluid is connected to the by-passing the in-line sample reservoir, and (b) a second operating modus wherein the sample conduit is connected to the conduit by-passing the in-line sample reservoir, and the source of carrier fluid is connected to the structure elucidation spectrometer via the in-line sample reservoir. Decoupling of the electrochemical cell from the spectrometer allows for uncompromised selection of optimal electrochemical and separation conditions. The apparatus further provides an automated method of sequentially analyzing a plurality of samples for electrochemically active substances sequentially and fully automatically. | 06-13-2013 |
20130199945 | Methods and Devices to Generate Luminescence From Integrated Electrode Chips By Cathodic and Bipolar Pulses - The invention describes novel chemiluminescence electrode devices and their novel properties to enable achieving luminescence signal by electrical excitation by cathodic or bipolar pulses in aqueous electrolyte solutions. These devices form a significant improvement in construction of cheap and reliable means for especially diagnosis of health conditions in point-of-need purposes. | 08-08-2013 |
20130206610 | Integrated carbon electrode chips for the electric excitation of lanthanide chelates, and analytical methods using these chips - Electrochemiluminescent technique and device suitable for cheap analytical and diagnostic applications, with electrodes manufactured from carbon paste and terbium chelates as labeling compounds. | 08-15-2013 |
20130206611 | Accurate Integrated Low-Cost Electrode Chips for Point-Of-Need Analysis and A Method of Utilization in Hot Electron-Induced Electrochemiluminescent Systems - The invention relates to integrated electronic chip (lEChip) cartridge devices which are used in hot electron-induced electrochemiluminescence methods and to instrumentation based on the electrical excitation of label molecules with subsequent measurement of luminescence in order to quantitate analyte concentrations especially in bioaffinity assays, especially outside of central laboratories. | 08-15-2013 |
20130233727 | METHOD OF MEASURING GLYCOSYLATED PROTEIN PROPORTION BY AC IMPEDANCE METHOD - A method of measuring a glycosylated protein proportion by an AC impedance method includes passing an AC voltage or AC to two inspecting electrodes; covering a solution containing glycosylated protein completely onto the inspecting electrodes; measuring an impedance value between the electrodes and calculating the difference between the impedance value and an impedance value of a solution without glycosylated protein by an AC impedance inspection device; comparing the impedance difference with AC impedance difference/glycosylated protein concentration to obtain the proportion of the glycosylated protein in the solution containing glycosylated protein. The solution without glycosylated protein includes a salt solution and a non-glycosylated protein; the proportion of glycosylated protein in the solution containing glycosylated protein refers to the proportion of glycosylated protein in the total quantity of protein in the salt solution; and the proportion of glycosylated hemoglobin of the total quantity of hemoglobin in the salt solution. | 09-12-2013 |
20130233728 | AMPEROMETRIC ELECTROCHEMICAL SENSORS, SENSOR SYSTEMS AND DETECTION METHODS - An amperometric electrochemical sensor configured to be operable in an oxidizing atmosphere and under an applied bias to exhibit enhanced reduction of oxygen molecules at the sensing electrode in the presence of one or more target gas species and a resulting measurable increase in oxygen ion flux through the cell. The sensor has an electrolyte membrane, a sensing electrode on the electrolyte membrane, and a counter electrode on the electrolyte membrane, wherein the sensing electrode includes at least one molybdate or tungstate compound. An electrochemical sensor system is also provided, along with a method of detecting the concentration of one or more of NOx and NH | 09-12-2013 |
20130240377 | Voltammetric Systems for Assaying Biological Analytes - The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect. | 09-19-2013 |
20130256154 | FUNCTIONALIZED GRAPHENE OR GRAPHENE OXIDE NANOPORE FOR BIO-MOLECULAR SENSING AND DNA SEQUENCING - A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer or a graphene oxide layer. The nanopore could be oxidized to graphene oxide at an inner surface. The graphene or graphene oxide in the nanopore is coated with an organic layer configured to interact with biomolecules in a different way in order to differentiate the biomolecules. The organic layer enhances resolution and motion control of the biomolecules. A time trace of ionic current is monitored to identify the biomolecules based on a respective interaction of the biomolecules with the organic layer. | 10-03-2013 |
20130270124 | BIOSENSOR ELECTRODE FOR HER2 DETECTION, A METHOD FOR PRODUCING IT, A METHOD FOR REGENERATING IT - A method of forming a biosensor electrode for HER2 detection is provided. The method includes providing a metal electrode, forming a metal electrode/3-mercaptopropionic acid (MPA) by depositing MPA on the metal electrode, forming a metal electrode/MPA/n-hydroxy-succinimide (NHS) by ester-bonding between NHS and the MPA on the metal electrode/MPA, and forming a metal electrode/MPA/aptamer by amide-bonding between an HER2 specific aptamer having an amino terminus and the MPA of the metal electrode/MPA/NHS. | 10-17-2013 |
20130306492 | Method and apparatus for assay of electrochemical properties - A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component. | 11-21-2013 |
20130327656 | Biosensor Using Impedimetric Real-Time Monitoring - A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution. The amount and/or allocation of point mutation(s) within the target DNA and/or RNA is then determined by calculating the denaturation-time constant based on the difference between the first and second impedance value and taking into account the impact of the chemical by third impedance value. | 12-12-2013 |
20130341206 | AMPEROMETRIC GAS SENSOR - The disclosed invention relates to an amperometric gas sensor for measuring the concentration of an analyte, comprising: a solid support; and a working electrode in contact with the solid support; wherein the analyte comprises a dopant which when in contact with the solid support increases the electrical conductivity of the solid support. A sterilization process employing the amperometric gas sensor is disclosed. | 12-26-2013 |
20140014533 | Determining Blood Coagulation Characteristics - In some examples, a device applies an electrical potential difference across a blood sample. The device measures an electrical signal that passes through the blood sample over a duration of time to obtain a plurality of measurements representing a measurement function of time. An accumulative property of the measurement function may be determined such that the accumulative property correlates to a blood coagulation characteristic. | 01-16-2014 |
20140014534 | ELECTROCHEMICAL DETECTION OF CAPSAICINOID COMPOUNDS IN A SAMPLE - An electrochemical method for capsaicinoid and/or related compound detection in a sample by way of a screen printed electrode having a working electrode, a reference electrode, and a counter electrode. The working electrode can be screen-printed using conductive carbon ink; the reference electrode can be screen printed using conductive carbon ink; and the counter electrode can be screen printed using silver/silver chloride. The method includes contacting the electrode with the sample in the presence of electrolyte solution, and determining whether a change in redox potential occurs by way of differential pulse voltammetry, wherein a modulation amplitude is between approximately 0.1 volt/min and approximately 2.0 volt/min, a step potential is between approximately 0.0005 volt and approximately 0.01 volt, a modulation time is 0.05 seconds, and a corresponding interval time is approximately 0.5 second. | 01-16-2014 |
20140021066 | DETECTION OF TARGET ANALYTES USING PARTICLES AND ELECTRODES - The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined. | 01-23-2014 |
20140021067 | LOW CONCENTRATION AMMONIA NANOSENSOR - An electrochemical sensor for sensing a gaseous analyte includes a substrate having at least two electrodes disposed thereon, and a carbon nanotube-polyaniline (CNT/PANI) film disposed on the substrate and in contact with at least two electrodes. The CNT/PANI film includes carbon nanotubes coated with a thin layer of polyaniline. The thickness of the polyaniline coating is such that electron transport can occur along and/or between the carbon nanotubes. | 01-23-2014 |
20140069823 | Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device - A disposable urea sensor has a laminated body having a fluid sample inlet end and an electrical contact end, a fluid sample inlet, a substantially flat sample chamber in communication between the fluid sample inlet and a vent opening, the sample chamber being adapted to collect a fluid sample through the fluid sample inlet, a working electrode and a reference electrode within the sample chamber, and a reagent matrix disposed on the working electrode wherein the reagent matrix contains urease. | 03-13-2014 |
20140083866 | DEVICE AND METHOD FOR DETECTING REDOX REACTIONS IN SOLUTION - Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA. | 03-27-2014 |
20140102916 | Electrochemical flow cell - Described is an electrochemical flow cell ( | 04-17-2014 |
20140116892 | Apparatus and Method for Evaluating Characteristics of Target Molecules - Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined. | 05-01-2014 |
20140124383 | ELECTRODE CHIP FOR DETECTING BIOLOGICAL MOLECULE, AND METHOD FOR DETECTING BIOLOGICAL MOLECULE - An electrode chip for detecting a biomolecule includes a substrate; and an electrode that includes an electrode substrate, at least one of a metallic salt or a metallic oxide provided on an outermost surface on an opposite side of the electrode substrate from a side provided with the substrate, and a biomolecular probe-immobilizing material which is provided on the outermost surface and to which a biomolecular probe is fixed. | 05-08-2014 |
20140174952 | POTENTIOMETRIC DEVICE AND METHOD SELECTIVE FOR PIOGLITAZONE - The potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone. The potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein. The ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone. The polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP). | 06-26-2014 |
20140216950 | ERYTHROPOIETIN RECEPTOR MODIFIED ELECTRODE AND ITS PREPARATION METHOD AND APPLICATION - The invention discloses an erythropoietin receptor modified electrode, which is a glassy carbon electrode with erythropoietin receptor as recognition element fixed onto the electrode surface via ZnO sol-gel. The modified electrode can be prepared easily, and its performance is stable. After 50-day storage in the dark at 4° C., its response current remained approximately 77% of the original value. An electrochemical biosensor using this modified electrode as working electrode, a platinum electrode as counter electrode, a saturated calomel electrode as reference electrode, and 2 mmol/L K | 08-07-2014 |
20140251831 | LEAK DETECTION FORMULA, ANALYZER and METHODS OF USE - Detecting a leak from a site in a sealed system with a source of pressurized gas which is capable of passing through the site, a composition of matter which adheres to the surfaces of the system and which is capable of showing the presence of the gas escaping from the site. The method includes: injecting gas into the system to a pressure in excess of the surrounding pressure, and covering the external surface with the composition to identify the location of the site by the interaction of the escaping gas with the composition. The composition is foam that includes a surfactant which forms a least one bubble in the presence of escaping gas and an indicator which changes color in the presence of the escaping gas. The leak is an opening down to at least the size of a hole 0.001″ in diameter. A gas detector may also be used. | 09-11-2014 |
20140251832 | Electrochemical Assay - An electrochemical assay uses paramagnetic particles ( | 09-11-2014 |
20140262832 | ELECTROCHEMICAL DETECTION OF BETA-LACTOGLOBULIN - A method to detect beta-lactoglobulin (BLG) is described. The method includes the steps of adding a known concentration of hydrogen peroxide to a sample known to, or suspected of containing BLG; and electrolyzing the sample using a working electrode at a fixed potential sufficient to electrolyze BLG, and measuring a current signal within the sample. A diminution of the current signal in the sample as compared to a corresponding current signal from a standard solution containing a known concentration of hydrogen peroxide and no BLG indicates that the sample contains BLG. | 09-18-2014 |
20140284222 | Detection Of Synergistic And Additive Trace Gases - Described herein is a gas meter system ( | 09-25-2014 |
20140346059 | Compositions, Devices, Systems, and Methods for Using a Nanopore - Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 11-27-2014 |
20140346060 | ELECTROCHEMICAL DETECTION OF BETA-LACTOGLOBULIN - A method to detect beta-lactoglobulin (BLG) is described. The method includes the steps of adding a known concentration of hydrogen peroxide to a sample known to, or suspected of containing BLG; and electrolyzing the sample using a working electrode at a fixed potential sufficient to electrolyze BLG, and measuring a current signal within the sample. A diminution of the current signal in the sample as compared to a corresponding current signal from a standard solution containing a known concentration of hydrogen peroxide and no BLG indicates that the sample contains BLG. | 11-27-2014 |
20150021203 | AMPEROMETRIC GAS SENSOR - The disclosed invention relates to an amperometric gas sensor for measuring the concentration of an analyte, comprising: a solid support; and a working electrode in contact with the solid support; wherein the analyte comprises a dopant which when in contact with the solid support increases the electrical conductivity of the solid support. A sterilization process employing the amperometric gas sensor is disclosed. | 01-22-2015 |
20150021204 | AMPEROMETRIC GAS SENSOR - The disclosed invention relates to an amperometric gas sensor for measuring the concentration of an analyte, comprising: a solid support; and a working electrode in contact with the solid support; wherein the analyte comprises a dopant which when in contact with the solid support increases the electrical conductivity of the solid support. A sterilization process employing the amperometric gas sensor is disclosed. | 01-22-2015 |
20150027906 | SOLID POLYMER ELECTROLYTE AMMONIA SENSOR - An ammonia sensor that includes an ionic liquid impregnated sensing electrode (anode) and a cathode separated by a membrane. During operation, in the presence of ammonia, the anode and cathode generate current manifesting the electrochemical reaction of ammonia in the sensing electrode. Ionic liquids distributed in the ionomer film in the gas diffusion electrodes ensure the reactivity under wide range of environment conditions while maintaining the ability of the device to quantify ammonia concentration in the environment. The sensor can therefore sustain long time operation without internal humidification due to the non-volatility of the ionic liquids. | 01-29-2015 |
20150122669 | ELECTRODE AND USE THEREOF - The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm | 05-07-2015 |
20160025675 | METHOD FOR ELECTRONIC BIOLOGICAL SAMPLE ANALYSIS - A biological sample analysis device includes a casing that encloses a biological sample delivery system hydraulically coupled to a sensor, wherein the sensor includes a plurality of Graphene transistors and each transistor covalently bonds with a biomarker causing the electrical properties of the transistor to measurably change when the biomarker is exposed to corresponding antibodies within an infected biological sample. | 01-28-2016 |
20160097759 | CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS - The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer. | 04-07-2016 |
20160103092 | ELECTROCHEMICAL GAS SENSOR, LIQUID ELECTROLYTE AND USE OF A LIQUID ELECTROLYTE IN AN ELECTROCHEMICAL GAS SENSOR - An electrochemical gas sensor ( | 04-14-2016 |
20160116430 | LIQUID ELECTROLYTE FOR AN ELECTROCHEMICAL GAS SENSOR - A liquid electrolyte, for an electrochemical gas sensor for detecting NH | 04-28-2016 |
20170234826 | CONCENTRATION MEASUREMENT METHOD, CONCENTRATION MEASUREMENT PROGRAM, CONCENTRATION MEASUREMENT SYSTEM, AND CONCENTRATION MEASUREMENT DEVICE | 08-17-2017 |
20190145945 | ELECTROCHEMICAL GAS SENSOR FOR USE IN ULTRA LOW OXYGEN STORAGE ENVIRONMENTS | 05-16-2019 |