| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 205778000 | And using semipermeable membrane | 28 |
| 20080197024 | ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. | 08-21-2008 |
| 20090026092 | Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds - Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic compounds susceptible to oxygenation and organophosphate compounds susceptible to hydrolysis are disclosed herein, as well as biosensor arrays, methods of detecting and quantifying analytes within a mixture, and devices and methods for delivering reagents to enzymes disposed within the distal tip of a biosensor. | 01-29-2009 |
| 20090071847 | ELECTROCHEMICAL TEST SENSOR WITH REDUCED SAMPLE VOLUME - An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. At least a portion of the width of the counter electrode is greater than the width of the working electrode. | 03-19-2009 |
| 20090194429 | Apparatus and Method for Sensing a Time Varying Ionic Current in an Electrolytic System - An apparatus and method for sensing time varying ionic current in an electrolytic system having a first fluid chamber and a second fluid chamber separated by a barrier structure is provided, wherein the barrier structure includes thick walls and a substrate having an orifice therein, with the first and second fluid chambers being in communication via the orifice. A potential is applied between electrodes in respective first and second fluid chambers, thus driving an electrical current between them and through the orifice. Total capacitance of the system is less than 10 pF. Analytes are added to one of the first and second fluid chambers and time varying ionic current that passes across the orifice is measured. An amplifier proximal to the barrier structure and electrodes amplifies the ionic current signal. | 08-06-2009 |
| 20090266719 | Potentiometric Urea Sensor Based on Ion-Selective Electrode - A sensor for sensing and measuring a concentration of urea in a sample has an ammonium ion selective membrane and urease enzymes immobilized on the ammonium ion selective membrane. The urease enzymes enzymatically convert urea into ammonium ions, which is sensed by said ammonium ion selective membrane and transformed into a signal. A detector system is used for processing signal from said ammonium ion selective membrane to generate a response potential that corresponds to the concentration of urea in the sample. | 10-29-2009 |
| 20090321277 | ELECTRON-CONDUCTING CROSSLINKED POLYANILINE-BASED REDOX HYDROGEL, AND METHOD OF MAKING - A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose. | 12-31-2009 |
| 20100116691 | BIOSENSOR FOR CONTINUOUS MONITORING OF METABOLITES AND PROTEINS AND METHODS OF MANUFACTURE THEREOF - A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates. | 05-13-2010 |
| 20100163431 | Sensor - This invention relates to a sensor for detecting an analyte in the presence of at least one interferent in a fluid sample. The sensor comprises a substrate, a channel disposed on the substrate, at least one transducer disposed in the channel, and a filter for selectively absorbing the analyte in preference to the at least one interferent. The filter is arranged in the channel remotely from the at least one transducer and the channel defines a flow path for the fluid sample such that the fluid sample contacts a first transducer to generate a first signal, followed by the filter, followed by the first transducer or a second transducer to generate a second signal. | 07-01-2010 |
| 20100176005 | High-throughput Biological Screening Assay Using Voltage Gradients - A high throughput biological screening assay comprising at least two anodes, at least two cathodes acting as the reference electrode, and a polymer membrane placed between each anode and cathode, wherein the at least two anodes comprise a biological culture, and wherein the at least two cathodes comprise an oxidizing agent and a buffering agent. The high throughput biological screening assay wherein the at least two cathodes are connected in parallel to simulate the connection between the same cathode and different anodes. The high throughput biological screening assay further including an external resistor or open circuit and means for measuring the voltage across the external resistor or open circuit. A method of measuring power generation using a single cathode as a reference electrode to monitor the biological production of energy. A method of correlating bacterial biofilm formation within an operational microbial fuel cell directly to current output. | 07-15-2010 |
| 20100320094 | Nanopore Platforms for Ion Channel Recordings and Single Molecule Detection and Analysis - A nanopore device includes a membrane having a nanopore extending there through forming a channel from a first side of the membrane to a second side of the membrane. The surface of the channel and first side of the membrane are modified with a hydrophobic coating. A first lipid monolayer is deposited on the first side of the membrane, and a second lipid monolayer is deposited on the second side of the membrane, wherein the hydrophobic coating causes spontaneous generation of a lipid bilayer across the nanopore orifice. Sensing entities, such as a protein ion channel, can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages, while resistance or current flow through the sensing entity can be measured electrically. | 12-23-2010 |
| 20120186997 | LAYERED ENZYME COMPOSITIONS FOR USE WITH ANALYTE SENSORS - Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes. | 07-26-2012 |
| 20120211373 | MICROFLUIDIC SYSTEM FOR MEASURING CELL BARRIER FUNCTION - The present invention relates to devices, systems and methods for measuring cell barrier function. In particular, the present invention relates to microfluidic devices for use in in vitro models of the blood-brain barrier and modeling the transport across this barrier. | 08-23-2012 |
| 20120279873 | ADHESIVE COMPOSITION FOR USE IN AN IMMUNOSENSOR - An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same. | 11-08-2012 |
| 20130032492 | Detection Method for Sensor Membrane of EuTixOy as Part of a Biosensor by Using PNIPAAm for Wrapping Enzymes - A detection method for a sensor membrane formed of EuTi | 02-07-2013 |
| 20130199944 | ANALYTE SENSOR - The present disclosure relates generally to an electrochemical sensor comprising a membrane layer comprising one or both of an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion, at least one electrode disposed beneath the membrane and either at least one pH sensor or a hematocrit sensor. The present disclosure also relates to methods of adjusting analyte concentration values using a correction factor based on measured pH values and/or measured hematocrit levels. | 08-08-2013 |
| 20130264221 | MEMBRANE PHASE ELECTRODE USING PRINTING AND BIO-MOLECULE DETECTION USING SAME - A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc. | 10-10-2013 |
| 20130334062 | HANDHELD DEVICE FOR ELECTROPHYSIOLOGICAL ANALYSIS - A handheld device for analysis of electro-physiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip comprising a pathway for fluid, said pathway connecting an open end of the pipette tip to an analysis substrate comprised in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel in said ion channel-containing lipid cellular membrane, when said lipid cellular membrane is held at a predetermined site of the substrate, e.g. for patch clamp analysis. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump of the handheld body and said pathway, and to provide an electric connection between the electronic controller and at least one of said electrodes of the substrate. The electronic controller of the handheld body is configured to operate the assembled device for micfofluidic analysis of aspirated fluid. | 12-19-2013 |
| 20140001056 | METHOD USING FLUORINATED AMPHIPHILES | 01-02-2014 |
| 20140209483 | Printable hydrogel for biosensors - Methods and apparatus are provided for manufacturing an analyte detecting device. In one embodiment, the method comprises providing a substrate, applying a plurality of layer of materials on said substrate; applying a layer containing at least one mediator; and screen printing a hydrogel on the layer. | 07-31-2014 |
| 20140262831 | WHOLE BLOOD HEMOLYSIS SENSOR - The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood. | 09-18-2014 |
| 20140318985 | POTENTIOMETRIC SENSORS AND METHOD FOR MEASURING INTERMOLECULAR INTERACTIONS - A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface. | 10-30-2014 |
| 20140332409 | Chip for a pathogens, parasites, toxins and desired chemical compounds detection - The present invention is directed to a method and apparatus for an immunoassay technique that uses amperometric measurements to rapidly analyze different pathogenic microorganisms, including bacteria, viruses, toxins, and parasites and chemical compounds using a disposable element. In accordance with one aspect of the present invention, at least one conductive immunosorbent is used to provide support for antibody immobilization and placed on the top of the working electrode; it could also be used by itself as a working electrode. This immunosorbent or powder can be fabricated of conductive material or nonconductive material over which a conductive material is coated. A membrane cover of the working electrode forms a fluidic chamber having a pore size that is suited to the particular application to insure no contact between the working electrode and counter or silver electrode. The immunoassay can be automated using microprocessor control to reduce the amount of human intervention. | 11-13-2014 |
| 20150300982 | Microbially-Based Sensors for Environmental Monitoring - The present invention relates to the field of surface water monitoring. More specifically, the present invention provides low-cost, real-time bio-electrochemical sensors for surface water monitoring based on the metabolism of one or more electrogenic microbes. | 10-22-2015 |
| 20160123917 | Sensor and Method for Removing Interfering Substance - A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter. | 05-05-2016 |
| 20160161439 | Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium - There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied. | 06-09-2016 |
| 20160161440 | Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium - There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied. | 06-09-2016 |
| 20160202204 | ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH ULTRA-THIN DISCONTINUOUS METAL LAYER | 07-14-2016 |
| 20160249840 | PH MICROSENSOR FOR GLUCOSE AND OTHER ANALYTE SENSOR FAULT DETECTION | 09-01-2016 |
