| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 073610560 | Detail of fluid handling means (e.g., valve, control, etc.) | 66 |
| 20080245136 | Closed Loop Flow Control of a Hplc Constant Flow Pump To Enable Low-Flow Operation - A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate anti precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<μL/min) HPLC flow rates. | 10-09-2008 |
| 20080307861 | Method For Screening Mobile Phases In Chromatography Systems - A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure. | 12-18-2008 |
| 20090038381 | AUTOMATED PACKING SYSTEM AND METHOD FOR CHROMATOGRAPHY COLUMNS - A column packing system comprises a control unit provided with software for monitoring the column interior pressure and/or flow through the column for use in calculating the breakpoint where a movable adapter comes into contact with a consolidated bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression. | 02-12-2009 |
| 20090090174 | Precision Flow Control System - A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven. | 04-09-2009 |
| 20090193879 | SOLVENT DELIVERY DEVICE AND ANALYTICAL SYSTEM - Disclosed herein is a stable solvent delivery device capable of delivering solvent both at high pressure and at constant flow rate. | 08-06-2009 |
| 20090205409 | SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS - A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp. | 08-20-2009 |
| 20100024527 | SYSTEMS AND METHODS FOR HIGH-THROUGHPUT SCREENING OF FLUIDIC SAMPLES - Aspects of the invention provide systems and methods for high-throughput screening of fluidic samples. In some embodiments, two chromatography columns are utilized in series. The first chromatography column can have a high affinity for phosphorylated compounds while the second chromatography column has a high affinity for one or more analytes of interest. | 02-04-2010 |
| 20100058841 | FLOW DISTRIBUTING VALVE - A rotary valve ( | 03-11-2010 |
| 20100083739 | Chromatography System with Fluid Intake Management - A liquid chromatograph includes a mobile phase supplying apparatus including a plurality of liquid-feeding pumps to feed mobile phases, a plurality of liquid-feeding flow paths, a mixer to mix the mobile phases by merging the liquid-feeding flow paths, at least one control device to control driving of each of the liquid-feeding pumps based on flow rates for the respective liquid-feeding flow paths, a plurality of flow rate measuring sections provided downstream of the liquid feeding pump in each liquid-feeding flow path, the plurality of actual flow rate measuring sections configured to measure an actual flow rate and to detect a back-flow in the corresponding liquid-feeding flow path, and a plurality of actual flow rate computing sections configured to compute an actual flow rate in the corresponding liquid feeding flow path. The liquid chromatograph also includes a sample injecting section downstream of the mobile phase supplying apparatus where the mobile phases are supplied from the mobile phase supplying apparatus, a separating column for provided downstream of the sample injecting section for separating an injected sample into its constituents, and a detector for detecting each of the separated constituents. When one of the plurality of actual flow rate measuring sections detects a back-flow in the corresponding liquid-feeding flow path, the corresponding actual flow-rate computing section computes an actual back-flow rate and outputs a signal to the corresponding control device which controls the corresponding liquid-feeding pump so as to cancel the back-flow based on the computed actual flow rate. | 04-08-2010 |
| 20100107742 | APPARATUS AND METHODS OF FLUID CHROMATOGRAPHY - The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 μl/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides. | 05-06-2010 |
| 20100139376 | IC SYSTEM INCLUDING SAMPLE PRETREATMENT AND USING A SINGLE PUMP - An IC system including sample preparation. The system includes a liquid sample injection loop, an ion concentrator, an ion separator, and only a single pump for pumping fluid through the system. | 06-10-2010 |
| 20100199750 | Microfludic Analysis System and Method - A microfluidic processing system having a manifold with at least one inlet; at least one outlet; and a plurality of microfluidic chip holders. A fluidic jumper is coupled to one of the chip holders and at least two fluidic elements are coupled to at least one of the chip holders. The fluidic jumper controls the fluidic path through the system. | 08-12-2010 |
| 20100275678 | PRIMARY PISTON CORRECTION DURING TRANSFER - A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle. | 11-04-2010 |
| 20100281959 | SHEAR VALVE WITH DLC COMPRISING MULTI-LAYER COATED MEMBER - A shear valve for use in a high performance liquid chromatography system, the shear valve comprising a first shear valve member and a second shear valve member, wherein at least one of the first and second shear valve members is adapted to be moved with respect to the other, one of the first and second shear valve members comprises a plurality of ports, and the other comprises at least one fluid path for fluidly coupling respective ones of the ports in dependency on a relative movement position of the first and second shear valve members with respect to each other, wherein the first shear valve member is at least partially coated with an adhesion-promoting layer and a diamond like carbon layer on the adhesion-promoting layer. | 11-11-2010 |
| 20100288026 | LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector | 11-18-2010 |
| 20100288027 | PUMP FOR LIQUID CHROMATOGRAPH - A pump device is realized, which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor | 11-18-2010 |
| 20110005305 | LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector. | 01-13-2011 |
| 20110083493 | Liquid Chromatography Detector and Flow Controller Therefor - A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector. | 04-14-2011 |
| 20110132077 | MULTI-WAVELENGTH LIGHT SOURCE - A fluid separation system ( | 06-09-2011 |
| 20110179856 | ANALYZING DEVICE - A liquid chromatography device includes a column containing a filler, an injection valve capable of introducing a sample into the column and also capable of introducing a liquid mobile phase into the column, and a mobile phase feeder for feeding the liquid mobile phase from a mobile phase container containing the liquid mobile phase to the column via the injection valve. Between the mobile phase container and the injection valve is provided a storage chamber for temporarily storing the liquid mobile phase sent from the mobile phase container. The device further includes a liquid level detection sensor for detecting the liquid level of the liquid mobile phase in the storage chamber. This structure allows the liquid for use in analysis to be used completely without being wasted. | 07-28-2011 |
| 20110185797 | ANALYZING DEVICE AND METHOD FOR CONTROLLING SAME - An analyzing device includes a feeder connected to a container in which a sample is contained for sucking the sample from the container and feeding the sample, and a controller for performing control for feeding from the feeder to a measurer. In measuring the sample, the controller performs control so that results of a plurality of times of measurement are obtained with respect to the single container in which the sample is contained, without changing the container. This arrangement allows quick accuracy check. | 08-04-2011 |
| 20110209532 | AUTOMATIC SAMPLER FOR LIQUID CHROMATOGRAPH - A pump portion for taking in and discharging solutions includes a first plunger pump with a small capacity and a second plunger pump with a large capacity. Intake ports of both the plunger pumps are connected in parallel to a common port of a switching valve with a first three-way valve interposed therebetween. The first three-way valve connects the intake port of one of the plunger pumps to the switching valve. Discharge ports of both the plunger pumps are connected in parallel to one port of the switching valve with a second three-way valve interposed therebetween. The second three-way valve connects the discharge port of one of the plunger pumps to the switching valve. | 09-01-2011 |
| 20110232373 | CHROMATOGRAPHIC SEPARATION DEVICE WITH VARIABLE LENGTH AND A METHOD FOR ITS USE - The present invention enables the automatic change of the number of segments involved in a coupled chromatographic column system, without the need to physically detach and attach the individual segments. The present invention further relates to a method for performing method development in chromatography and for selecting the optimal separation conditions to perform a chromatographic separation using the system of the present invention. | 09-29-2011 |
| 20110239746 | APPARATUS FOR METHOD FOR POLYMER CHARACTERIZATION - Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations. | 10-06-2011 |
| 20120031174 | SOLVENT DELIVERY PUMP AND LIQUID CHROMATOGRAPH - A cleaning chamber is provided in a seal holder and two cleaning chamber flow paths communicating with the cleaning chamber from outside are provided. A pipe connected to a vessel storing a mobile phase is connected to one of the cleaning chamber flow paths. A pipe as a flow path connected to a mobile phase sucking flow path into a pump chamber is connected to the other cleaning chamber flow path. When the mobile phase is taken in, the mobile phase is sucked into the pump chamber via the cleaning chamber. | 02-09-2012 |
| 20120118049 | FLUIDIC DEVICES AND METHODS USING THEM - Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system. | 05-17-2012 |
| 20120222470 | WAY OF METHOD TRANSFER OF LIQUID CHROMATOGRAPH AND LIQUID CHROMATOGRAPH SYSTEM - Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer. | 09-06-2012 |
| 20120227470 | Chromatography Apparatus Having An Integrated Core - A chromatography apparatus includes a sample-delivery patterned substrate and a tube-based separation column directly connected to an outlet port of the patterned substrate. The patterned substrate includes an injector valve connected to the outlet port. | 09-13-2012 |
| 20120240666 | Valve and Splitting System for Multi-Dimensional Liquid Analysis - A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis. | 09-27-2012 |
| 20130000390 | LIQUID CHROMATOGRAPH SYSTEM - A channel-switching valve into which a high-pressure liquid and a low-pressure liquid flow is provided. The channel-switching valve includes a stator and a rotor which has a surface in contact with one surface of the stator and rotates while sliding on the contact surface. The stator has a plurality of liquid flow ports open to the contact surface, and the rotor has a plurality of channel grooves for connecting the liquid flow ports. One of the channel grooves is a straight groove passing through the rotational center of the rotor, and the other channel grooves are line-symmetrically arranged with respect to the straight channel groove. Alternatively, among the channel grooves, the channel grooves into which the high-pressure liquid flows are configured to be located on both sides of the rotational center of the rotor. Thus, a local load acting on the rotor during a high-pressure liquid-feeding process is reduced. | 01-03-2013 |
| 20130014568 | LIQUID CHROMATOGRAPHY DEVICEAANM Lee; Sang-WonAACI SeoulAACO KRAAGP Lee; Sang-Won Seoul KRAANM Kim; Min-SikAACI SeoulAACO KRAAGP Kim; Min-Sik Seoul KRAANM Hyung; Seok-WonAACI SeoulAACO KRAAGP Hyung; Seok-Won Seoul KR - A liquid chromatography device includes a sample inlet valve to which a sample to be analyzed is introduced, and a trap valve fluid-communicating with a solid phase extraction column and a reverse phase liquid chromatography column. The device further includes a solvent dividing unit dividing flow of a solvent discharged from the sample inlet valve into the first solvent inlet port and the second solvent inlet port of the trap valve. The liquid chromatography device improves resolution and increases reproducibility by allowing the sample injecting direction and the sample eluting direction to be opposite to each other. | 01-17-2013 |
| 20130091935 | LIQUID CHROMATOGRAPH AND PUMP UNIT FOR LIQUID CHROMATOGRAPH - In a liquid chromatograph and a pump unit for liquid chromatograph whereby a sample is analyzed while changing the mixing ratio of multiple kinds of solvents, mixing of the solvents can be accelerated without adding any novel device such as a mixer. The pump unit for liquid chromatograph has a configuration which comprises cylinders for introducing a multiple kinds of solvents thereinto and plungers that are reciprocated so as to introduce the solvents and discharge the same for sending, wherein a plurality of channels are formed in the cylinders for mixing the solvents. | 04-18-2013 |
| 20130104631 | PUMP FOR LIQUID CHROMATOGRAPH, AND LIQUID CHROMATOGRAPH | 05-02-2013 |
| 20130220001 | CHROMATOGRAPHY SYSTEMS AND METHODS USING THEM - Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described. | 08-29-2013 |
| 20130276520 | Rotary Shear Injector Valve With Displaced Rotor Grooves - A valve includes a stator that has fluidic ports in a seal surface, and a rotor that has a seal surface contacting the stator's seal surface. The rotor has through-holes that extend from the seal surface to a back surface, providing fluidic communication with a conduit disposed adjacent to the back surface of the rotor. A chromatography apparatus includes a sample source, a solvent source having a higher operating pressure than the sample source, and an injector valve. A method of performing chromatography includes loading a sample with a valve in a load-state configuration that disposes a sample source in fluidic communication with a conduit disposed adjacent to a back surface of the rotor, and injecting the loaded sample with the valve in an inject-state configuration that disposes a solvent source in fluidic communication with a column via at grooves adjacent to a front seal surface of the rotor. | 10-24-2013 |
| 20130312501 | Inline filter housing assembly - A novel filter housing assembly for use in liquid chromatography and similar fluid flow based systems capable of use at high pressure, well above 1000 psi, is disclosed. The filter housing assembly has a very low dead volume of approximately 11 μL and is capable of holding brittle ceramic filter membranes as well as flexible membranes without the support of a fit. The filter housing is capable of being assembled and disassembled by hand without the need of any tools and makes use of an inexpensive, disposable filter retaining screen. | 11-28-2013 |
| 20130340509 | Flow Through Isolation Valve For High Pressure Fluids - A flow through isolation valve having a stationary member; a movable member, with a surface of the stationary member interfacing with a surface of the movable member; and at least one pin isolation valve. The pin isolation valve has a flow through internal conduit and is movable so that the internal conduit can fluidically communicate with at least one blank opening in the movable member and with a flow through internal conduit in the movable member. Movement is by rotation, linear or curvilinear translation. At least one pin isolation valve is fluidically coupled typically to a sample loop of a face seal valve, or to a pump supplying high pressure liquid to or to a column discharging liquid from a face seal valve of a high pressure liquid chromatography (HPLC) system or directly to the face seal valve. | 12-26-2013 |
| 20140026647 | Connection Assembly for Ultra High Pressure Liquid Chromatography - A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing. | 01-30-2014 |
| 20140060163 | LIQUID SENDING PIPE FOR LIQUID CHROMATOGRAPH DETECTOR AND LIQUID CHROMATOGRAPH - A heat insulating member | 03-06-2014 |
| 20140157878 | SYSTEM AND PROGRAM FOR CONTROLLING LIQUID CHROMATOGRAPH - A liquid chromatograph control system for controlling an operation of a liquid chromatograph which uses a mobile phase composed of a mixture of solvents and which has the function of performing a gradient analysis while temporally changing the mixture ratio of the solvents. The system initially requests a user to set a basic gradient profile (Step S12), and subsequently, to set the number of steps to change the mixture ratio of the mobile phase at the beginning and/or at the end of the gradient process as well as the amount of change in the mixture ratio per step (Step S13). After that, based on the possible combinations of the mixture ratios of the mobile phase at the beginning and at the end of the gradient process computed from the contents of information entered in the previous steps, a plurality of gradient profiles corresponding to those combinations are created (Step S14). | 06-12-2014 |
| 20140238113 | METHOD FOR MEASURING STABLE HEMOGLOBIN A1c USING LIQUID CHROMATOGRAPHY, AND METHOD FOR SIMULTANEOUS MEASUREMENT OF STABLE HEMOGLOBIN A1c AND ABNORMAL HEMOGLOBIN USING LIQUID CHROMATOGRAPHY - An object of the present invention is to provide a method capable of measuring stable hemoglobin A1c using liquid chromatography in a short time with good reproducibility. | 08-28-2014 |
| 20140260564 | Connector with structural reinforcement and biocapatible fluid passageway - A connector with a biocompatible fluid passageway and method for manufacturing thereof is described. The biocompatible connector may be used in an analytical instrument (AI) system as a union, an adapter, a tee, a cross, a manifold, a valve, or for other fittings or components. The connector has a reinforcement insert and a biocompatible molding covering portions of the reinforcement insert. The reinforcement insert has a first portion, a second portion, and a middle portion between the first portion and the second portion. The first and second portions have threaded sections and each have a plurality of non-threaded sections. For a given portion, the junction of the non-threaded sections forms a lip by which to prevent the molded material from flowing into the threaded sections. In certain embodiments, an interior web is used in the reinforcement insert to provide additional structural support. | 09-18-2014 |
| 20140260565 | LIQUID FEED PUMP AND LIQUID CHROMATOGRAPH - A recess into which a protrusion of a plunger seal is to be fitted is provided at a part of a pump head where a plunger is to be inserted into a pump chamber. The plunger seal seals the pump chamber by an outer circumferential surface of the protrusion coming into close contact with an inner circumferential surface of the recess and a surface of a flange on the side of the protrusion coming into close contact with a circumferential edge surface of the recess of the pump head due to the protrusion being fitted into the recess and being pressed by a backup ring toward the pump chamber. The inner circumferential surface of the recess of the pump head and the circumferential edge surface of the recess are covered by a film of an acid-resistant material. | 09-18-2014 |
| 20140305195 | PREPARATIVE COLUMN CHROMATOGRAPHY SYSTEM - A chromatography system comprising a mixing circuit or a mixing chamber, a bubble trap, a concentration detector and one or more pumps, characterized in that the bubble trap has a permanent opening at its highest point is described herein. Furthermore, a chromatography system is described, characterized in that it contains two concentration detectors the first of which is located in the mixing circuit or the mixing chamber and the second is located downstream of the main pump. | 10-16-2014 |
| 20140318224 | HIGH-PRESSURE CONSTANT FLOW RATE PUMP AND HIGH-PRESSURE CONSTANT FLOW RATE LIQUID TRANSFER METHOD - A high-pressure constant flow rate pump transfers a solvent from a low-pressure side liquid transfer system even if a difference between mixing ratios is large when solvents are mixed during high-pressure gradient liquid transfer. A pressure detection value from a second pressure sensor and a pressure detection value from a fourth pressure sensor are compared with each other. If the pressure detection value P | 10-30-2014 |
| 20140345372 | MANAGING FLUIDIC CONNECTIONS TO MICROFLUIDIC DEVICES - A system (e.g., a chromatography system) includes a rotor, a microfluidic device, a rotor driver, a clamping mechanism, and control electronics. The rotor defines a plurality of first fluid-conveying features. The micro fluidic device defines one or more channels and a plurality of second fluid-conveying features, in fluid communication with the one or more channels. The rotor driver is coupled to the rotor and is configured to rotate the rotor, relative to the microfluidic device, between a first position and a second position such that, in each of the positions, at least one of the first fluid-conveying features cooperates with at least one of the one or more channels to provide for fluid communication therebetween. The clamping mechanism is operable to provide a sealing force to establish a fluid-tight seal between the rotor and the microfluidic device. | 11-27-2014 |
| 20140352411 | Nebulizer for Charged Aerosol Detection (CAD) System - A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector. | 12-04-2014 |
| 20150040648 | LIQUID CHROMATOGRAPHY DEVICE, LIQUID CHROMATOGRAPHY ANALYSIS PROCESS, AND NON-TRANSITORY COMPUTER-READABLE MEDIUM - A liquid chromatography device includes an adsorption portion that adsorbs one or more analysis components in a specimen, an analysis device that analyzes an analysis component eluted by an eluent, a main feeding device that feeds a first eluent to the adsorption portion, the first eluent eluting an analysis component, a feeding channel in fluid communication with the main feeding device and the adsorption portion, a first retention channel that retains a second eluent, the second eluent differing from the first eluent, an auxiliary feeding device that feeds the second eluent to the first retention channel, and a first switching device that switches the feeding channel to either a first channel or a second channel, the first channel allowing the first eluent to flow from the main feeding device to the adsorption portion, and the second channel allowing the second eluent to flow from the first retention channel to the adsorption portion. | 02-12-2015 |
| 20150047422 | INTRODUCING SAMPLES INTO SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS - A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection. | 02-19-2015 |
| 20150316516 | MIXER BYPASS SAMPLE INJECTION FOR LIQUID CHROMATOGRAPHY - In a liquid chromatography system, a sample is injected into a column by flowing a solvent mixture from a mixer into the column along a solvent mixture flow path; and injecting a sample into the solvent mixture flow path downstream of the mixer. In another liquid chromatography system, a sample is injected into a column by loading an isolator fluid into a sample loop, loading a sample into the sample loop, and flowing the sample into the column as a plug in front of the isolator fluid. | 11-05-2015 |
| 20150346168 | SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS - A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp. | 12-03-2015 |
| 20160011154 | METHODS OF DETECTING AND IDENTIFYING MUNITIONS COMPOUNDS | 01-14-2016 |
| 20160011155 | Apparatus for Field-Flow Fractionation | 01-14-2016 |
| 20160018370 | PREPARATIVE SEPARATION CHROMATOGRAPH SYSTEM - A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value. | 01-21-2016 |
| 20160054273 | TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY SYSTEM FOR HEART-CUT METHOD - Provided is a two-dimensional liquid chromatography system, and more particularly, a two-dimensional liquid chromatography system capable of performing both independent one-dimensional separation through a reversed-phase or normal-phase chromatography method and two-dimensional separation for removing a matrix effect in a single system. | 02-25-2016 |
| 20160061788 | SWITCHING VALVE FOR FLOW TYPE ANALYSIS APPARATUS - A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port. | 03-03-2016 |
| 20160069846 | Methods and Apparatus for Analyzing Samples and Collecting Sample Fractions - Methods and apparatus for analyzing a sample using at least one detector are disclosed. | 03-10-2016 |
| 20160069848 | LIQUID CHROMATOGRAPH MASS SPECTROMETER - In a liquid chromatograph mass spectrometer (LC/MS) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional LC or similar LC with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the LC depending on the kind of column or other factors or the degree of ease of ionization in the MS. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information. By selecting fractionated samples at each dimension of the multi-dimensional LC, the number of fractionated samples to be eventually subjected to mass spectrometry can be significantly reduced. | 03-10-2016 |
| 20160077065 | LIQUID CHROMATOGRAPH, DEVICE AND METHOD FOR CALCULATING ELUTION TIME, AND DEVICE AND METHOD FOR DETERMINING MIXTURE RATIO - Provided that elapsed time from the start of the flow-in of an eluent into a column is t0 and the mobility R | 03-17-2016 |
| 20160131617 | LIQUID FLOW RATE MEASUREMENT DEVICE - Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors. | 05-12-2016 |
| 20160131619 | VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS - A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into fist and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis. | 05-12-2016 |
| 20160139093 | HPLC SAMPLE INTRODUCTION WITH COUPLING SAMPLE RESERVOIRS IN PARALLEL BETWEEN MOBILE PHASE DRIVE AND SEPARATION UNIT - Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit. | 05-19-2016 |
| 20160377184 | Fluid Switching Valve and Liquid Chromatograph Apparatus Using the Same - Provided are: a flow path switching valve that reduces the pressure load in a contact surface outer peripheral section of the flow path switching valve and inhibits friction between constituent components; and a liquid chromatographic device using the flow path switching valve. The flow path switching valve is provided with a stator having a plurality of through holes and a seal having conduction grooves for causing the through holes to conduct. The seal has a first portion present vertically beneath a region comprising at least a surface of contact with the stator, and a second portion having lower rigidity than the first portion, on the outside of the first portion. Due to this configuration, it is possible to reduce the pressure load when a flow path of a liquid is switched under high-pressure conditions, and inhibit the phenomenon of friction itself. | 12-29-2016 |
| 20160377582 | Methods and Systems for Detection of Non-Volatile Solutes - A system for detection of non-volatile solutes dissolved in solution comprises: a spray emitter system configured to receive a flow of the solution and generate an aerosol comprising droplets thereof, the generated droplets comprising a restricted size range; a spray chamber configured to receive the aerosol and emit a modified aerosol comprising droplets having a diameter smaller than a predetermined value; a conduit configured to receive a flow of the modified aerosol and to evaporate the solvent so as to generate an aerosol comprising solid particles of the solutes; a charging chamber configured to receive the aerosol and impart electric charge to the solid particles; and a detector configured to measure a quantity of charge imparted to the solid particles, wherein the restricted size range is such that solid particles having diameters greater than 10 nm comprise a substantial portion of all particles received by the charging chamber. | 12-29-2016 |
| 20160377644 | AUTOMATED FLUID HANDLING SYSTEM - Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel. | 12-29-2016 |
| 20220137008 | LIQUID CHROMATOGRAPH - A liquid chromatograph includes: a liquid meter that measures a liquid amount of a mobile phase stored in one or more mobile phase containers; and a notification unit that notifies an operator of the liquid amount of the mobile phase in each of the one or more mobile phase containers measured by the liquid meter. According to such a liquid chromatograph, when the operator replenishes the mobile phase to the mobile phase container, it is not necessary to visually measure the liquid amount of the mobile phase or manually input the value to the control device, so that it is possible to reduce the workload of the operator regarding the liquid amount management of the mobile phase. | 05-05-2022 |
