| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 034284000 | Freeze-drying | 75 |
| 20090107000 | Method and Device for Freeze-Drying Products - The invention relates to a method and to a device for freeze-drying products using a chamber ( | 04-30-2009 |
| 20090107001 | Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma - Single unit human plasma is dispensed from a source transfer bag into a receptacle in which the plasma under goes freeze-drying. During the dispensing of the plasma from the source transfer container into the freeze-drying receptacle, an inline treatment device treats the plasma prior to freeze-drying, e.g., by the removal of cellular blood components, or by the removal of pathogens or viral or bacterial agents, or by the removal or neutralization of blood group specific antibodies. | 04-30-2009 |
| 20090113753 | Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma - A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual. | 05-07-2009 |
| 20100018073 | METHOD FOR MONITORING THE SECONDARY DRYING IN A FREEZE-DRYING PROCESS - A method to monitor a secondary drying phase of a freeze-drying process comprises initial steps in which is provided to perform pressure rise tests at different time and to calculate a respective value of experimental desorption rate of product (steps 1 to 3). Subsequently, the method provides to estimate initial conditions and kinetic constants of a kinetic model of the process (step 4) and to calculate at time t=t | 01-28-2010 |
| 20100107436 | METHOD AND SYSTEM FOR CONTROLLING A FREEZE DRYING PROCESS - A method for monitoring and/or controlling a freeze drying process is characterized by the use of an estimator algorithm. A product to be dried is arranged in at least one container on a temperature-controlled shelf in the drying chamber of a freeze dryer apparatus. During a primary drying phase, the drying chamber is isolated by closing an isolating valve. Pressure values inside the drying chamber are measured and collected for a defined pressure collecting time and a temperature of the temperature-controlled shelf. A product temperature for the product is calculated together with a plurality of process/product related parameters. A new shelf temperature is calculated with a sequence of shelf temperatures up to the end of the primary drying phase that maximizes a sublimation rate of the product in order to maintain the product temperature below a maximum allowable product temperature. | 05-06-2010 |
| 20100186252 | FREEZE-DRYING METHOD AND APPARATUS - A freeze-drying apparatus comprises a vertical tube ( | 07-29-2010 |
| 20100242300 | FREEZE DRYER BARRIER SYSTEM - This invention is directed to freeze dryers used in the pharmaceutical industry, and in particular, to a barrier system for freeze dryers located in an isolator or clean room facilitate sterilization of the isolator. | 09-30-2010 |
| 20100251560 | Holder - A sleeve consisting of metal and having a planar base manufactured to low fabrication tolerances for holding a cartridge, or other container for pharmaceutical products, filled with a pharmaceutical product, prior to, and during, freeze-drying is proposed. The sleeve has a cylindrical receptacle, into which a cartridge may be inserted. The base of that receptacle may have openings. Since the base of the metallic sleeve is manufactured to low fabrication tolerances, heat transfer from the cooling plate on which the sleeve containing the cartridge stands to the sleeve will be improved. Heat transfer from the sleeve to the interior of the cartridge will also be improved, since the latter is surrounded by the sleeve over the full length of the sleeve, thereby forming an enlarged surface, along which radiative heat transfer takes place. The sleeve preferably extends up to the level of the liquid pharmaceutical product arranged in the cartridge. | 10-07-2010 |
| 20110078916 | SUPERCOOLING PROMOTING AGENT - During the investigation of the mechanism that cellular water in woody plants growing in cold districts keeps liquid state at low temperature, the inventors have studied to identify the causative substances. As the results, the present inventors identified supercooling promoting agents in woody plants. | 04-07-2011 |
| 20110138646 | APPARATUS AND METHOD FOR CONTINUOUS LYOPHILIZATION - A method and apparatus for the continuous sublimation of a substance includes cascading a material containing a substance capable of sublimation, such as water, between a plurality of trays vertically stacked within a processing zone provided within a processing chamber. A substantially atmospheric environment is maintained within the processing zone at a temperature whereby the substance sublimes forming a sublimate within the environment. The environment containing the sublimate is contacted with a drying agent such as a desiccant to maintain the environment whereby the substance sublimes at substantially atmospheric pressure and at the controlled temperature. | 06-16-2011 |
| 20110154681 | THERMAL SHIELDING TO OPTIMIZE LYOPHILIZATION PROCESS FOR PRE-FILLED SYRINGES OR VIALS - A device for supporting at least one vessel containing a target material to be lyophilized generally includes a support panel, a central region, a perimeter region, a thermal shield, and at least one shielding cavity. The support panel has a support surface. The central region is defined by the support panel for supporting the at least one vessel. The perimeter region is also defined by the support panel and surrounding the central region. The thermal shield is positioned about the perimeter region and extends transverse to the support surface of the support panel such that the thermal shield and the support panel define a storage space for accommodating the at least one vessel. The at least one shielding cavity is defined by the thermal shield and contains a shielding material during a lyophilization process. The shielding material is distinct from the target material. | 06-30-2011 |
| 20110154682 | Device and Method for Automatically Opening and Closing a Material Container During a Lyophilization Process - A device for storing a material to be lyophilized includes a support panel, a sidewall, an opening, a cover, and at least one lifter device. The sidewall and the support panel define a storage space for accommodating a material. The opening is defined by a rim of the sidewall. The cover is removably disposed adjacent to the rim of the sidewall for closing the opening. The lifter device is disposed between the support panel and the cover and includes a reservoir and at least one movable wall. The reservoir defines a sealed cavity containing a fluid. The movable wall is in operable communication with the fluid in the sealed cavity and engaging the cover to displace the cover away from the rim when the lifter device is subject to an ambient pressure that is less than the pressure of the fluid in the sealed cavity. | 06-30-2011 |
| 20110162227 | PYRROLOBENZODIAZEPINES - Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios. | 07-07-2011 |
| 20110232123 | Freeze Dryer Slot Door Actuator and Method - Movement of a slot door of a freeze dryer is driven by a rack and pinion actuator. The actuator is easily sanitized and includes internal elements that are accessible to sanitizing sprays. The pinions are driven by pinion shafts that pass through a seal separating an aseptic area from a non-aseptic area where the drive train is positioned. Only rotary motion is transferred across the aseptic barrier, reducing the need for a bellows or sliding covers, which are difficult to sanitize. | 09-29-2011 |
| 20120030963 | APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS - An apparatus and method for microwave vacuum-drying of temperature-sensitive biological materials on a continuous flow-through basis, in which the materials are frozen, ground to frozen particles, dehydrated to a powder, and the powder collected. The apparatus ( | 02-09-2012 |
| 20120159803 | METHOD AND ASSEMBLY FOR HANDLING CONTAINERS IN A FREEZE DRYER - Method for transfer of containers, such as vials ( | 06-28-2012 |
| 20120227277 | METHODS FOR FREEZE DRYING - A method for producing a fog of ice nuclei by introducing a cryogenic fluid and a humid gas stream into a freeze dryer. The cryogenic fluid and humid gas stream will form ice nuclei having a preferred size for introduction into vials contained in the freeze dryer. | 09-13-2012 |
| 20130008048 | Device and Method for Controlling a Dehydration Operation During a Freeze-Drying Treatment - A device for controlling the dehydration operation during a freeze-drying treatment comprises a freeze-drying chamber ( | 01-10-2013 |
| 20130118025 | LYOPHILISATION TARGETING DEFINED RESIDUAL MOISTURE BY LIMITED DESORPTION ENERGY LEVELS - A process of freeze drying of an essentially aqueous solution comprising at least one first step having a first temperature and pressure level (i.e. primary drying phase) and at least one second step having a second temperature and pressure level (i.e. secondary drying phase) following the first step, wherein in the secondary drying phase limited desorption energy input is applied. | 05-16-2013 |
| 20130118026 | BULK FREEZE DRYING USING SPRAY FREEZING AND STIRRED DRYING - A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration. | 05-16-2013 |
| 20130205612 | THIN FILM MULTILOCULAR STRUCTURE MADE OF COLLAGEN, MEMBER FOR TISSUE REGENERATION CONTAINING THE SAME, AND METHOD FOR PRODUCING THE SAME - A new structure made of collagen for improving promotion of nerve tissue regeneration, curing and regeneration of a defective part of a soft biological tissue and so on without using laminin or nerve growth factor (NGF), and a member for tissue regeneration including the same. The structure made of collagen has a thin film multilocular formation and is therefore a new structure different from a colloid form, a gel form, and a fiber form. When the new structure made of collagen is used as a member for tissue regeneration, surprisingly, promotion of regeneration, shortening of a treatment period, functional recovery, or the like of bodily tissue such as nerve tissue, subdermal tissue, submucosal tissue, membranous tissue, fat tissue, muscle tissue, skin tissue, and gingival tissue can be improved. When the structure is used in a patient having neuropathic pain, the member has an effect on the disappearance of the pain. | 08-15-2013 |
| 20140007454 | APPARATUS AND METHOD FOR CONTINUOUS LYOPHILIZATION - A method and apparatus for the continuous sublimation of a substance includes cascading a material containing a substance capable of sublimation, such as water, between a plurality of trays vertically stacked within a processing zone provided within a processing chamber. A substantially atmospheric environment is maintained within the processing zone at a temperature whereby the substance sublimes forming a sublimate within the environment. The environment containing the sublimate is contacted with a drying agent such as a desiccant to maintain the environment whereby the substance sublimes at substantially atmospheric pressure and at the controlled temperature. | 01-09-2014 |
| 20140026434 | Calculation Method and Calculation Device for Sublimation Interface Temperature, Bottom Part Temperature, and Sublimation Rate of Material to be Dried in Freeze-Drying Device | 01-30-2014 |
| 20140101964 | DELAMINATION DRYING APPARATUS AND METHOD - An apparatus for delamination drying a substrate is provided. A chamber for receiving a substrate is provided. A chuck supports and clamps the substrate within the chamber. A temperature controller controls the temperature of the substrate and is able to cool the substrate. A vacuum pump is in fluid connection with the chamber. A tilting mechanism is able to tilt the chuck at least 90 degrees. | 04-17-2014 |
| 20140190035 | OPTIMIZATION OF NUCLEATION AND CRYSTALLIZATION FOR LYOPHILIZATION USING GAP FREEZING - This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously. The as frozen solution then provides a lyophilized cake of the solutes with large and uniform pores. | 07-10-2014 |
| 20140215845 | METHOD AND SYSTEM FOR FREEZE-DRYING INJECTABLE COMPOSITIONS, IN PARTICULAR PHARMACEUTICAL COMPOSITIONS - The invention relates to a method for freeze-drying injectable compositions, in particular pharmaceutical compositions, comprising: A) storing a quantity of a dispersion of an injectable composition in an aqueous dispersion medium in at least one ready-to-use vial, B) rotating the vial at least for a period of time to form a dispersion layer at an inner surface of a circumferential wall of the vial, C) during rotating of the vial according to step B) cooling the vial to form ice crystals at the inner surface of the circumferential wall of the vial, and D) drying the cooled composition to sublime at least a portion of the ice crystals formed in the dispersion by substantially homogeneously heating the circumferential wall of the vial. The invention also relates to a freeze-dried composition obtained by the method according to the invention and a system for freeze-drying injectable compositions, in particular pharmaceutical compositions, in particular by making use of the method according to the invention. | 08-07-2014 |
| 20140230264 | Method of the Preparation of Fibrillar and Lamellar Porous Microstructures and Nanostructures by Means of Controlled Vacuum Freeze-Drying of Liquid Nanoparticles Dispersions - The invention relates to a method of preparation of lamellar porous microstructures and nanostructures of various density based on controlled vacuum freeze-drying of a liquid dispersion of nanoparticles. | 08-21-2014 |
| 20140230265 | FREEZE-DRYING APPARATUS WITH A LOADING AND UNLOADING DEVICE - A freeze-drying apparatus ( | 08-21-2014 |
| 20140230266 | PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES - A process line ( | 08-21-2014 |
| 20140245629 | PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES - A process line ( | 09-04-2014 |
| 20140259724 | Low Aspect Ratio Staged Closure Devices, Systems, and Methods for Freeze-Drying, Storing, Reconstituting, and Administering Lyophilized Plasma - The inventive device and methods described herein address the introduction of a safe and effective freeze-dried biological product, and particularly a plasma product, to a subject in need thereof. The present invention relates to a multifunctional, staged closure device, which also is described as a lyophilization container for plasma (LCP). The device and methods described herein address how to reproducibly achieve a low moisture and substantially oxygen-free atmosphere within a finally hermetically sealed biocompatible low aspect plastic vessel within a standard shelf-stoppering freeze dryer. The present inventive device and methods provide a freeze-dried plasma product that is fully traceable, preserves the constituent plasma activity, is readily prepared in a sterile fashion, is stable, ensures ease of storage and permits rapid reconstitution and delivery to a patient. | 09-18-2014 |
| 20140325868 | LYOPHILIZATION SYSTEM AND METHOD - System and method for lyophilization or freeze-drying is provided. During the freezing step, the material or solution to be frozen is initially brought to a temperature near or below its freezing temperature after which the pressure in the freeze-dryer chamber is reduced to induce nucleation of the material. | 11-06-2014 |
| 20140373382 | USING SURFACE HEAT FLUX MEASUREMENT TO MONITOR AND CONTROL A FREEZE DRYING PROCESS - A method of monitoring and controlling a freeze drying process in a freeze drying apparatus having walls, shelves and a number of vials or trays positioned on different areas of the shelves and containing product to be freeze dried. One or more vials or trays are selected that are representative of the positions of all of the vials or trays in different areas of the shelves. One or more heat flux sensors are positioned between the selected vials or trays and adjacent portions of the walls and/or shelves. The heat transfer between the selected vials or trays and the adjacent wall or shelf portions is measured during the freezing and drying stages of the freeze drying process. | 12-25-2014 |
| 20150089830 | PROCESS AND APPARATUS FOR TREATING CONTAINERS FOR STORING SUBSTANCES FOR MEDICAL, PHARMACEUTICAL OR COSMETIC APPLICATIONS - In a process and apparatus for treating or processing containers ( | 04-02-2015 |
| 20150101208 | DRYER WITH MONITORING DEVICE - The invention provides a monitoring device ( | 04-16-2015 |
| 20190145705 | FREEZE-DRYING METHOD AND DEVICE | 05-16-2019 |
| 034285000 | With separating of frozen fluid from treated material | 4 |
| 20090158612 | PROCESS FOR PREPARING A LYOPHILISED MATERIAL - A process for preparing a lyophilized material, providing a container having a penetrable envelope and containing the material in a carrier liquid, whereby the penetrable region is penetrated with a penetrator which provides a conduit through the envelope, and the carrier liquid id evaporated out of the container via the conduit, after which the penetrator is withdrawn. Apparatus suitable for performing the process is also disclosed. | 06-25-2009 |
| 20100242301 | FREEZE-DRYER AND METHOD OF CONTROLLING THE SAME - A freeze-dryer and method of controlling the same is provided. The disclosed freeze-dryer includes a chamber adapted to hold material or product to be freeze-dried; one or more depressurization orifices; a gas pressurization circuit having a source of gas to pressurize the chamber to a prescribed pressure; a depressurization circuit coupled to the chamber via the one or more orifices and having a depressurizing control valve; and a control unit adapted to pressurize the chamber with the source of gas and actuate the depressurizing control valve to depressurize the chamber upon command. The ratio of total depressurization orifice area to the chamber volume is preferably between about 6×10 | 09-30-2010 |
| 20120090192 | METHOD FOR DRYING MICROFIBRILLATED CELLULOSE - The invention relates to a method for drying microfibrillated cellulose, comprising at least the following steps: (i) applying a composition comprising microfibrillated cellulose and a liquid onto a cold surface; (H) removing the frozen composition formed in step (i) from said surface to form frozen particles; (iii) optionally increasing the size of the frozen particles formed in step (ii); (iv) drying the frozen particles formed in step (iii) comprising: subjecting said particles to a cold moving gas thus removing liquid by means comprising sublimation and optionally (v) isolating the microfibrillated cellulose formed in step (iv). The invention also relates to a device for carrying out the method of the invention. | 04-19-2012 |
| 034286000 | With gas or vapor flow to remove frozen fluid | 1 |
| 20120246964 | Monitoring Freeze Drying With Gas Measurement On Vacuum Pump Exhaust - Parameters of a freeze drying process are monitored by measuring trace materials in the vacuum pump exhaust. The measurements are made using techniques such as acousto-optic spectrometry, multipass cavity-enhanced absorption spectrometry (CEAS) and cavity ring-down spectrometry (CRDS). The technique may be used to diagnose problems such as leakage in the freeze drying shelves, leakage in the condensation coils, leaks from atmosphere in the chambers and the presence of residual cleaning materials. The technique may also be used to monitor the presence of water vapor in the exhaust of a secondary drying process. | 10-04-2012 |
| 034287000 | Including vacuum | 26 |
| 20080229609 | Preservation by Vaporization - Significant research is being done to develop and improve delivery mechanisms for biopharmaceuticals and vaccines, including pulmonary (inhalation), nasal, transdermal, and oral alternatives. Market projections indicate that the delivery of proteins and vaccines by inhalation and oral formulation has become and will continue to be increasingly important. These delivery mechanisms, to be effective, will require better stabilization of the biologicals so that they can maintain potency and effectiveness at ambient temperatures for extended periods of time. The novel Preservation by Vaporization (PBV) Technology described herein provides cost-effective and efficient industrial scale stabilization of proteins, viruses, bacteria, and other sensitive biologicals, thereby allowing a production of products that are not possible to be produced by existing methods. The suggested new PBV process comprises primary drying under vacuum from a partially frozen state (i.e. slush) at near subzero temperatures followed by stability drying at elevated temperatures (i.e., above 40 degrees Celsius). The new suggested method can be performed aseptically in unit doze format (in vials) and/or in bulk format (in trays, bags, or other containers). The drying can be performed as a continuous load process in a manifold vacuum dryer comprising a plurality (e.g., 30) of vacuum chambers attached to a condenser during the drying. | 09-25-2008 |
| 20080244923 | METHOD FOR LYOPHILIZING AN ACTIVE AGENT - A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices. | 10-09-2008 |
| 20080276482 | Freeze Drying of Target Substances - A target substance ( | 11-13-2008 |
| 20090260253 | Apparatus and method of drying using a gas separation membrane - An membrane drying system comprising: a chamber, a vacuum pump, a sweep gas source, and a membrane device, wherein the membrane device comprises a membrane, a first inlet in fluid communication with the chamber and the membrane, a first outlet in fluid communication with the membrane and the vacuum pump, a second inlet in fluid communication with the sweep gas source and the membrane, and a second outlet in fluid communication with the membrane. | 10-22-2009 |
| 20100101106 | LYOPHILIZING TRAY EMPLOYING REAGENT CARTRIDGE, LYOPHILIZING SYSTEM EMPLOYING THE SAME, AND METHOD OF PREPARING LYOPHILIZED REAGENT - A method of manufacturing a lyophilized reagent, including mounting a plurality of reagent cartridges in which a liquid reagent is loaded in a tray including one or more tunnel-shaped first rails having opened end portions in a lengthwise direction and an opening formed in the top of the one or more first rails; closing the opened end portions, placing the tray in a lyophilizer and lyophilizing the liquid reagent according to a lyophilizing program. | 04-29-2010 |
| 20100107437 | VACUUM FREEZE-DRYING APPARATUS AND METHOD FOR VACUUM FREEZE DRYING - A vacuum freeze-drying apparatus capable of rapid drying is provided. A cold trap for drying, which is arranged inside a drying chamber, is set to a low temperature of −70 degrees Celsius or below, and heat is supplied to frozen particles on a conveyor belt to a degree such that the frozen particles do not melt. The amount of the liquid component evaporating from the frozen particles increases, and the amount of the liquid component entering the frozen particles decreases so that the time for drying the frozen particles is shortened. | 05-06-2010 |
| 20100132212 | METHOD FOR THE PREPARATION OF FLUOROPOLYMER POWDERED MATERIALS - A method for the preparation of fluoropolymer powdered materials is disclosed. A suspension of solid fluoropolymer particles in a liquid carrier, preferably water, is frozen and the frozen carrier is then removed by sublimation at sub-atmospheric pressure to produce a dry powder of fluoropolymers particles. | 06-03-2010 |
| 20100154245 | LYOPHILIZATION METHOD AND DEVICE - A lyophilization device configured for use in a lyophilization process has a body defining a chamber for receiving a liquid to be lyophilized, and a stopper creating a liquid-tight seal between the chamber and ambient atmosphere to form a sealed, empty sterile chamber. The stopper is adapted so that the chamber may be sterile filled with the substance through the stopper. A fluid passageway is formed through the stopper, through which the chamber is evacuated. The substance is lyophilized, the fluid passageway is closed, and the lyophilized substance is hermetically sealed within the chamber. | 06-24-2010 |
| 20100180464 | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture - The present invention relates to novel processes for the manufacture of cores of a specific polymer and a biologically active substance, and of such cores carrying a shell, i.e. microcapsules, to the cores and microcapsules thus produced, and to a pharmaceutical composition comprising such microcapsules. | 07-22-2010 |
| 20110099836 | LARGE-SCALE LYOPHILIZATION DEVICE - A device for large-scale lyophilization of pharmaceutical solutions in medical hollow bodies, includes a lyophilization device and at least one camera. Images of at least one pharmaceutical solution to be lyophilized are recorded by the at least one camera. The images may be used for controlling and/or monitoring the lyophilization process. | 05-05-2011 |
| 20110113644 | FREEZE-DRYING APPARATUS AND FREEZE-DRYING METHOD - [Object] To provide a freeze-drying apparatus and a freeze-drying method, which are capable of increasing a collection rate of a raw material without a need for providing a member such as a baffle plate or the like. | 05-19-2011 |
| 20110179667 | FREEZE DRYING SYSTEM - A method for distributing a cryogenic fluid inside a freeze drying chamber. The cryogenic fluid is fed into the freeze drying chamber through a venturi device. The cryogenic fluid will form an ice fog which will be rapidly and uniformly distributed throughout the freezing chamber and into the vials present in the freezing chamber. | 07-28-2011 |
| 20110192047 | FREEZE-DRYING APPARATUS AND FREEZE-DRYING METHOD - [Object] To provide a freeze-drying apparatus and a freeze-drying method, which are capable of increasing a drying efficiency of frozen particles. | 08-11-2011 |
| 20120192447 | Freeze drying method - A method of controlling the primary drying stage in a freeze drying apparatus having a shelf and bulk product or a number of vials in different areas on the shelf which contain product to be freeze dried. Temperature sensors are positioned in selected locations or vials which are representative of the different bulk product areas or the positions of all of the vials in different areas of the shelf. The temperature sensors are monitored and compared to determine the selected location or vial having the highest temperature while the temperature sensor therein is still in ice. The shelf temperature is controlled based on the selected location or vial with the highest temperature so long as the temperature sensor therein is still in ice. When the temperature sensor in the highest temperature selected location or vial is no longer in ice, another selected location or vial with the highest temperature and a temperature sensor therein that is still in ice is then used to control the shelf temperature. | 08-02-2012 |
| 20120192448 | OPTIMIZATION OF NUCLEATION AND CRYSTALLIZATION FOR LYOPHILIZATION USING GAP FREEZING - This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores. | 08-02-2012 |
| 20140059879 | USE OF NITROGEN GAS IN THAWING PLATES IN A LiN-BASED LYOPHILIZATION UNIT - This work is in simplifying the freezing and heating process required for a typical lyophilization process. From a liquid nitrogen supply tank called LIN tank, calculated quantity of vaporized nitrogen is transported the use point where a heater that uses heating media heats up nitrogen to a desired temperature and pass into the annular space of the steel plate where lyophilized solvent such as water of solvent is deposited on the outer surface of the plate. The heated nitrogen temperature will dictate the rate at which the solvent or water will be thawed. This unique process offer simplicity, safety and ease operation allowing the user to avoid heating oil as heating media, a common practice in the industry. | 03-06-2014 |
| 20140237846 | PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES - A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer ( | 08-28-2014 |
| 20140373383 | ROTARY DRUM FOR USE IN A VACUUM FREEZE-DRYER - A rotary drum ( | 12-25-2014 |
| 20160076810 | Method of Providing Inline Sterile Freeze Drying of a Product in Trays Accommodated in a Trolley, System for Carrying Out the Method, and Use of the Method - For providing inline sterile freeze drying of a product containing solid matter and a solvent, such as water, in a plurality of trays accommodated in at least one trolley, a system comprises a filling station having an inlet end and an outlet end, or a docking station, a freeze storage, a freeze dryer unit, an emptying station having an inlet end and an outlet end, or a docking station, a plurality of trays adapted to be accommodated in at least one trolley. A cleaning and sterilizing unit is provided between the outlet end of the emptying station and the inlet end of the filling station. | 03-17-2016 |
| 20160169579 | LYOPHILIZATION SYSTEM AND METHOD | 06-16-2016 |
| 20180023893 | METHOD AND DEVICE FOR OPTIMIZED FREEZE-DRYING OF A PHARMACEUTICAL PRODUCT | 01-25-2018 |
| 034289000 | And heating | 5 |
| 20120304483 | SUBSTRATE FREEZE DRY APPARATUS AND METHOD - An apparatus for freeze drying a substrate is provided. A chamber for receiving a substrate is provided. An electrostatic chuck (ESC) for supporting and electrostatically clamping the substrate is within the chamber. A temperature controller controls the temperature of the electrostatic chuck. A condenser is connected to the chamber. A vacuum pump is in fluid connection with the chamber. | 12-06-2012 |
| 034296000 | Having specific container | 3 |
| 20100236090 | Multilayer Plastic Container and Method of Storing Lyophilized Products - A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.-day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture. | 09-23-2010 |
| 20150128445 | DIRECTIONAL FREEZING - The invention relates to an apparatus and a method of freezing a liquid substance contained in at least one receptacle, comprising the steps of: providing the liquid substance in at least one receptacle, providing a cooling chamber and a cooling device having a cooling surface; setting the temperature of the cooling surface, starting a freezing procedure by placing the receptacle with the liquid substance therein on the cooling surface to form a seed or initial zone of nucleation; and continuing the freezing procedure to completely freeze the substance. | 05-14-2015 |
| 20150354894 | Lyophilization - Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma. | 12-10-2015 |
| 034297000 | Having specific type of material support | 1 |
| 20130239430 | VACUUM FREEZE-DRYING APPARATUS AND FROZEN PARTICLE MANUFACTURING METHOD - A technology for protecting a valve seat inside a collection tank from the adherence of frozen particles in a vacuum freeze-drying apparatus and a frozen particle manufacturing method. The inside of a vacuum tank and a collection tank are vacuum evacuated; a raw material liquid is injected into the vacuum tank to produce frozen particles; and the frozen particles are piled up on a surface of a heating/cooling shelf. When the frozen particles on the heating/cooling shelf are transferred into the collection tank through the inside of an auxiliary pipe, the frozen particles do not adhere to a valve seat which surrounds an opening of a main pipe inside the collection tank. | 09-19-2013 |
| 034298000 | With gas or vapor treating | 9 |
| 20090241364 | Drying and Freezing Method Without Cooling Medium - A drying and freezing method without cooling medium comprises the steps of removing moisture, separating cold air from hot air and mixing the cold air with the hot air. Under the condition of no cooling medium, the above-mentioned steps separate the moisture from the compressed air, separate the cold air from the hot air and mix the cold air with the hot air. The system using the drying and freezing method without cooling medium comprises at least one air dryer having an air-moisture separation chamber for separating air from moisture and at least one separator having a separation chamber for separating cold air from hot air. The separator is connected to a pipeline to mix the cold air with the hot air. | 10-01-2009 |
| 20100000111 | METHOD OF MEASURING MOISTURE CONTENT OF AN OBJECT FOR DRYING - The present invention provides a method of measuring moisture content of an object for drying during drying in a drying chamber by, for example, freeze-drying, fluidized bed drying or shelf drying, in real-time and in a non-destructive manner. According to the present invention, when measuring moisture content of an object for drying, a near infrared absorption spectrum of moisture present around the object for drying is measured, and the moisture content of the object for drying is calculated from a predetermined relationship based on a measured amount obtained from the measured near infrared absorption spectrum. | 01-07-2010 |
| 20120272544 | CONTROLLED NUCLEATION DURING FREEZING STEP OF FREEZE DRYING CYCLE USING PRESSURE DIFFERENTIAL ICE FOG DISTRIBUTION - A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of ice fog is created in a condenser chamber separate from the product chamber and connected thereto by a vapor port. The ice fog has a predetermined pressure that is greater than that of the product chamber, and is rapidly conveyed through the vapor port into the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber. | 11-01-2012 |
| 20130263467 | Device for subjecting products to a gas flow, for example, for a dry freeze process - A device for a supplying a gas flow to products, for example for a dry or freeze procedure, comprising a top and bottom grid, which are located parallel at a certain distance above each other, which top and bottom grid are both provided with a large amount of passage openings for the gas flow and in which, during operating, the to the gas flow subject products can be arranged on the upper grid, as well as flow generating means for generating and for providing the gas flow through the top and bottom grid towards the products. | 10-10-2013 |
| 20140041250 | CONTROLLED NUCLEATION DURING FREEZING STEP OF FREEZE DRYING CYCLE USING PRESSURE DIFFERENTIAL ICE CRYSTALS DISTRIBUTION FROM CONDENSED FROST - A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The condenser chamber has a predetermined pressure that is greater than that of the product chamber. The opening of the vapor port into the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber. | 02-13-2014 |
| 20140202025 | CONTROLLED NUCLEATION DURING FREEZING STEP OF FREEZE DRYING CYCLE USING PRESSURE DIFFERENTIAL ICE CRYSTALS DISTRIBUTION FROM CONDENSED FROST - A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The opening of the vapor port into the product chamber when the condenser chamber has a pressure that is greater than that of the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber. | 07-24-2014 |
| 20150040420 | CONTROLLED NUCLEATION DURING FREEZING STEP OF FREEZE DRYING CYCLE USING PRESSURE DIFFERENTIAL WATER VAPOR CO2 ICE CRYSTALS - A method of controlling and enhancing the nucleation of product in a freeze dryer wherein a product is maintained at a predetermined temperature and pressure. A mixture of water vapor and CO | 02-12-2015 |
| 20150128446 | FREEZE DRYER COUNTER-FLOW SHELF CONSTRUCTION AND METHOD - A shelf for a freeze dryer and method for enhancing temperature uniformity across the shelf. In one embodiment, the shelf has a lower shelf plate and an upper shelf plate mounted on the lower shelf plate and channels in a serpentine pattern are positioned between the upper and lower shelf plates to circulate heating or cooling fluid in a counter-flow pattern therebetween for temperature uniformity. The upper-shelf plate is formed of a temperature conductive material. | 05-14-2015 |
| 20160153713 | FREEZE-DRYING SYSTEM AND FREEZE-DRYING METHOD | 06-02-2016 |
