WASHINGTON, UNIVERSITY OF Patent applications |
Patent application number | Title | Published |
20120288880 | METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE - The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject. | 11-15-2012 |
20120107246 | METHOTREXATE-MODIFIED NANOPARTICLES AND RELATED METHODS - Methotrexate-modified nanoparticles that target tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles. | 05-03-2012 |
20120091632 | METHOD OF SELECTIVE FOAMING FOR POROUS POLYMERIC MATERIAL - A selective high intensity ultrasonic foaming technique is described to fabricate porous polymers for biomedical applications. Process variables, including ultrasound power, scanning speed, and gas concentration have an affect on pore size. Pore size can be controlled with the scanning speed of the ultrasound insonation and interconnected porous structures could be obtained using a partially saturated polymers. A gas concentration range of 3-5% by weight creates interconnected open-celled porous structures. The selective high intensity ultrasonic foaming method can be used on biocompatible polymers so as not to introduce any organic solvents. The method has use in cell related biomedical applications such as studying cell growth behaviors by providing a porous environment with varying topological features. | 04-19-2012 |
20120090764 | FOAMING METHODS FOR MAKING CELLULAR THERMOPLASTIC MATERIALS - Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the foams made therefrom, and methods for altering the impact strength of solid or noncellular thermoplastic materials and the shaping of the materials into useful articles. | 04-19-2012 |
20110301918 | DATA ACQUISITION FOR POSITRON EMISSION TOMOGRAPHY - A method for estimating the start time of an electronic pulse generated in response to a detected event, for example the start time for pulses received in response to photon detection in positron emission tomography, includes providing a detector that detects an external event and generates an electronic analog pulse signal. A composite reference pulse curve is calculated to represent analog pulse signals generated by the detector. Upon receiving an analog pulse signal, it may be filtered, and then digitized, and normalized based on the area of the digital signal. Using at least one point of the normalized digital pulse signal, the composite reference pulse curve shape is used to estimate the pulse start time. | 12-08-2011 |
20110294153 | REAGENT AND METHOD FOR DETECTION OF CARBOXYLIC ACIDS BY MASS SPECTROMETRY - Method and reagent for converting a carboxylic acid to a positively charged amide. The method and reagent facilitate positive ion mass spectral analysis of carboxylic acids. | 12-01-2011 |
20110201527 | TRAPPING OF MICRO AND NANO SCALE OBJECTS BASED ON LOCALIZED SURFACE PLASMON - Methods for optically trapping and manipulating micro- and nano-sized particles by using light to induce localized surface plasmon resonance on metallic surface of a substrate. The method includes the steps of contacting a substrate with a medium having particles suspended therein; focusing a beam of coherent light onto the substrate such that the beam induces surface plasmon resonance; and trapping at least one of the suspended particles using a light induced dielectrophoresis force generated by the surface plasmon resonance. | 08-18-2011 |
20110171457 | BIMODAL CELLULAR THERMOPLASTIC MATERIALS - Improvements to foaming methods and the interbimodal cellular structures of the foams made therefrom are disclosed, | 07-14-2011 |
20110169530 | CIRCUIT FOR CLASSIFYING SIGNALS - A circuit for classification of analog input signals, comprising an analog memory component, such as a floating gate, used to store a threshold value; a threshold detection module used to determine whether the analog input signal exceeds the threshold value; a time delay module used to delay a processing of the analog signal; a time-amplitude window calculation module used to determine whether an amplitude of the analog input signal is between a lower limit and an upper limit of an amplitude window; and an output module indicating whether the amplitude of the analog signal is between the lower and the upper limit, wherein the indication is used to determine whether the analog input signal belongs to one of a plurality of analog signal classes. The classification is implemented in the analog domain, eliminating the need for sampling and digitizing the analog signal, consequently minimizing circuit area and power. | 07-14-2011 |
20110159461 | TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE - A power toothbrush ( | 06-30-2011 |
20110150830 | COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS - The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections. | 06-23-2011 |
20110004272 | SCANNING LASER DEVICE AND METHODS OF USE - In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells. | 01-06-2011 |
20110003392 | System and Method for Magnetically Concentrating and Detecting Biomarkers - System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto. | 01-06-2011 |
20100292571 | NODULE SCREENING USING ULTRASOUND ELASTOGRAPHY - A medical device is configured to diagnose whether a nodule of a bodily organ is malignant or benign using ultrasound elastography to determine a nodule stiffness index. Using either an external compression source or an in vivo pulsation source, the stiffness of the nodule of the bodily organ can be quantified by either its static properties or dynamic properties. The nodule can be classified as Type I, which is benign requiring further observation, or Type II, which is malignant requiring invasive procedures. | 11-18-2010 |
20100260686 | Nanoparticles for brain tumor imaging - Nanoparticle having a chitosan-polyethylene oxide oligomer copolymer coating, and methods for making and using the nanoparticle are provided. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, one or more of an associated targeting agent, fluorescent agent, or therapeutic agent. | 10-14-2010 |
20100249267 | MARINE COATINGS - Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings. | 09-30-2010 |
20100247614 | HEMOSTATIC WOUND DRESSING - Hemostatic wound dressings that include cationic polymers and related hydrogels, methods for making and using the wound dressings. | 09-30-2010 |
20100234863 | NANOFIBROUS CONDUITS FOR NERVE REGENERATION - A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration. | 09-16-2010 |
20100222771 | Method for Controlled Electrospinning - An electrospinning apparatus and methodology is described that produces medical devices, such as scaffolds that induce the formation of a natural fibrous structure (primarily collagen and elastin) in a tissue-engineered medical device. The apparatus uses collection surfaces designed to manipulate or change the electrostatic field so that the electrospun fibers are arranged in desirable patterns that are similar to or mimic the fibrillar structure of an animal tissue. The manipulation results in fibers that are preferentially oriented in a predefined pattern. In addition, the interfiber space between the fibers and the fiber diameter are consistently within a predefined range. Using these techniques in conjunction with controlling polymer properties enables the production of a scaffold that has the structural and mechanical characteristics similar to the native tissue. | 09-02-2010 |
20100215749 | TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS - Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions. | 08-26-2010 |
20100167958 | TRAPPING OF MICRO AND NANO SCALE OBJECTS BASED ON LOCALIZED SURFACE PLASMON - Methods for optically trapping and manipulating micro- and nano-sized particles by using light to induce localized surface plasmon resonance on metallic surface of a substrate. The method includes the steps of contacting a substrate with a medium having particles suspended therein; focusing a beam of coherent light onto the substrate such that the beam induces surface plasmon resonance; and trapping at least one of the suspended particles using a light induced dielectrophoresis force generated by the surface plasmon resonance. | 07-01-2010 |
20100129823 | METHODS FOR IDENTIFYING SUBJECTS SUSCEPTIBLE TO ATAXIC NEUROLOGICAL DISEASE - In one aspect, the invention provides methods of identifying genetic mutations that are associated with ataxic neurological disease. The methods comprise identifying a difference between a nucleic acid sequence of a protein kinase C gamma gene from a mammalian subject exhibiting ataxia and a nucleic acid sequence of a protein kinase C gamma gene from a subject which is not exhibiting ataxia, wherein the difference is a genetic mutation associated with ataxic neurological disease. In another aspect, isolated nucleic acid molecules encoding protein kinase C gamma missense mutations are provided. In another aspect, a method of screening a subject to determine if the subject has a genetic predisposition to develop an ataxic neurological disease is provided. In another aspect, the invention provides kits for determining susceptibility or presence of ataxic neurological disease in a mammalian subject. | 05-27-2010 |
20100113252 | CROSSLINKED SILICONE COMPOUNDS AND METHODS FOR CROSSLINKING SILICONE COMPOUNDS BY IN SITU WATER GENERATION - Methods for crosslinking polysiloxane compounds, crosslinked polysiloxane compounds, methods for making ceramic products from the crosslinked polysiloxane compounds, and ceramic products made from the crosslinked polysiloxane compounds. | 05-06-2010 |
20100103368 | ACTIVE CONTACT LENS - An active contact lens system ( | 04-29-2010 |
20100099160 | DUAL-FUNCTIONAL NONFOULING SURFACES AND MATERIALS - Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery. | 04-22-2010 |
20100096640 | SELF-ASSEMBLED HETEROGENEOUS INTEGRATED OPTICAL ANALYSIS SYSTEM - Optical analysis system fluidically self-assembled using shape-coded freestanding optoelectronic components and a template having shape-coded recessed binding sites connected by an embedded interconnect network. Also includes methods of manufacture and use for optical analyses. | 04-22-2010 |
20100094131 | ULTRASONIC ESTIMATION OF STRAIN INDUCED BY IN VIVO COMPRESSION - An in vivo source of compression is used to cause a bodily structure of interest to expand and contract. Ultrasound signals are incident and their echoes are processed by a strain processor. Resulting strain images are freed from noise caused external sources of compression. A tissue stiffness index is calculated to obtain quantitative measure of stiffness. | 04-15-2010 |
20100074942 | DEVICE AND METHOD FOR INTRAOCULAR DRUG DELIVERY - Intraocular devices having a drug delivery construct attached thereto, and methods for using the devices for intraocular drug delivery and the treatment and/or prevention of conditions. | 03-25-2010 |
20100069550 | NANOPARTICLE ASSEMBLIES AND METHODS FOR THEIR PREPARATION - Nanoparticle assemblies comprising a plurality of nanoparticles and an amphiphilic polymer, and methods for making and using the nanoparticle assemblies. | 03-18-2010 |
20100069263 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides compositions and methods for preparing DNA sequencing libraries. In particular, the method relates to preparing DNA sequencing libraries from kilobase scale nucleic acids. The invention also provides methods for assembling short read sequencing data into longer contiguous sequences. The method is useful for various applications in genomics, including genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 03-18-2010 |
20100051915 | POLYMER CHARGE TRANSPORT MATERIAL FOR OPTOELECTRONIC DEVICES - Polymers that enable the use of high work-function metals as a cathode in optoelectronic devices and optoelectronic devices incorporating the polymers as an electron transport layer. | 03-04-2010 |
20100047559 | CORE-SHELL PARTICLES AND THEIR USE IN TOUGHENING POLYMER COMPOSITES - Core-shell particles and methods of making these particles are described as well as polymer composites comprising these particles. Cores comprise polymerized vinyl monomers and shells comprise polyamine polymers, where the polyamine polymers are covalently attached to the core. Use of these particles in polymer composites, such as epoxies, may impart improved toughness properties to the polymer composites. | 02-25-2010 |
20100041566 | ARRAYS AND METHODS FOR GUIDED CELL PATTERNING - Guided cell patterning arrays for single cell patterning, methods for making the arrays, and methods for using the arrays. | 02-18-2010 |
20100029953 | PHENYLTETRAENE-BASED NONLINEAR OPTICAL CHROMOPHORES - Alkoxy-substituted phenyltetraene nonlinear optically active compounds, films and devices that include the compounds, and methods for making and using the compounds, films, and devices. | 02-04-2010 |
20100015205 | BIOCOMPATIBLE AMINO ACID ANHYDRIDE POLYMERS - Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use. | 01-21-2010 |
20100003706 | SYPHILIS DIAGNOSTIC TESTS AND KITS - The present invention provides methods and kits for determining whether a human subject is infected with | 01-07-2010 |
20100001926 | CONTACT LENS WITH INTEGRATED LIGHT-EMITTING COMPONENT - A light-emitting contact lens and a method and system for tracking a user's eye position using the light-emitting contact lens are disclosed. The eye position tracking can be used, for example, to allow the user to interact with a display device such that the position of the user's eye determines the image generated by the display device. Thus, as the user's eye moves, the image on the display device will be altered to represent the new position (e.g., viewing angle) of the user with regard to the display device. | 01-07-2010 |
20090314714 | METHOD FOR REMOVING CONTAMINANTS FROM LIQUIDS USING MEMBRANE FILTRATION IN COMBINATION WITH PARTICLE ADSORPTION TO REDUCE FOULING - Metal oxide particles heated while immersed in water in a closed container are combined with membrane filtration to remove contaminants from water. The use of the heated particles reduces fouling of the membrane typically encountered when membranes alone are used to remove contaminants from water. | 12-24-2009 |
20090299021 | DIELS-ALDER CROSSLINKABLE DENDRITIC NONLINEAR OPTIC CHROMOPHORES AND POLYMER COMPOSITES - Diels-Alder crosslinkable dendritic nonlinear optical chromophore compounds, films and crosslinked polymer composites formed from the chromophore compounds, methods for making and using the chromophore compounds, films, and crosslinked polymer composites, and electro-optic devices that include films and crosslinked polymer composites formed from the chromophore compounds. | 12-03-2009 |
20090297388 | CRYSTALLINE NOBEL METAL NANOSTRUCTURES AND METHODS FOR THEIR PREPARATION - Crystalline noble metal nanostructures and methods for their preparation. | 12-03-2009 |
20090278445 | CROSSLINKABLE HOLE-TRANSPORTING MATERIALS FOR ORGANIC LIGHT-EMITTING DEVICES - Crosslinkable compounds useful for making hole-transporting materials for organic light-emitting devices, hole-transporting layers made from the crosslinkable compounds, and light-emitting devices that include the hole-transporting layers. | 11-12-2009 |
20090259015 | MIXED CHARGE COPOLYMERS AND HYDROGELS - Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units. | 10-15-2009 |
20090235988 | SOLAR CELLS BASED ON POLYMER NANOWIRES - Solar cells having active layers that include poly(3-alkylthiophene) nanowires. | 09-24-2009 |
20090230174 | SELF-ASSEMBLY OF ELEMENTS USING MICROFLUIDIC TRAPS - A self-assembly process is disclosed for integrating free standing microcomponents onto a template having a plurality of binding sites, an interconnect network, and trapping structures disposed downstream of the binding sites. The self-assembly is accomplished by flowing a fluid medium containing the microcomponents over the template such that some of the microcomponents are trapped at binding sites. The template may be simultaneously (or subsequently) heated to melt a binder such as a solder spot at each of the binding sites, and then cooled to connect the trapped microcomponents to the interconnect network. In one embodiment, removable blocking elements are disposed upstream of some of the binding sites, for example formed from photoresist. After assembling a first set of microcomponents, the blocking elements are removed, and a second set of microcomponents in a fluid medium are flowed over the template for assembly into the newly unblocked binding sites. | 09-17-2009 |
20090213459 | CONTACT LENS FOR THREE DIMENSIONAL VISUALIZATION - A contact lens set for stereoscopic visualization includes a left contact lens comprising a first lens substrate incorporating a first polarizer, and a right contact lens comprising a lens substrate incorporating a second polarizer. The first polarizer comprises a first plurality of parallel lines having sub-wavelength pitch and oriented in a first direction. The second polarizer comprises a second plurality of parallel lines having sub-wavelength pitch and oriented in a second direction. The left contact lens and the right contact lens each comprises a rotational stabilization means, such that, during use, the first direction is adapted to orient in an approximately orthogonal direction to the second direction. In another embodiment, a contact lens set for stereoscopic visualization includes a left contact lens and a right contact lens, each coded with different colors. | 08-27-2009 |
20090153021 | LARGE-BANDGAP HOST MATERIALS FOR PHOSPHORESCENT EMITTERS - Polymers and compounds having high-triplet-energy; guest-host films comprising the polymers or compounds as hosts and phosphorescent compounds as guests; and electroluminescent devices that include the films. | 06-18-2009 |
20090149618 | CROSSLINKABLE POLYMER HOST CONTAINING A NONLINEAR OPTICAL CHROMOPHORE GUEST - Crosslinked films having electro-optic activity, methods for making the films, and devices that include the films. The films include a crosslinked polymer host and guest polarizable chromophore compounds. | 06-11-2009 |
20090148717 | CROSSLINKABLE POLYMER HOST HAVING PENDANT NONLINEAR OPTICAL CHROMOPHORES AND CONTAINING A NONLINEAR OPTICAL CHROMOPHORE GUEST - Crosslinked films having electro-optic activity, methods for making the films, polymers useful in making the films, and devices that include the films. The films include a host crosslinked polymer having aligned polarizable chromophore moieties and aligned guest polarizable chromophore compounds. | 06-11-2009 |
20090130701 | NOVEL SEQUENCE VARIANTS OF MULTI-DRUG RESISTANCE GENES, MDR1 AND MRP1, AND RECOMBINANT CELLS EXPRESSING MRP1 AND MDR1 FOR ASSESSMENT OF DRUG PENETRATION AND DISPOSITION - Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological samples and elucidation of the influence of MDR1 polymorphisms on MDR1 protein function. Also provided are a rat MRP1 cDNA and protein, stable cell lines expressing the rat MRP1 protein, and methods of assessing drug penetration or disposition in a cell line expressing a recombinant mammalian MRP1 or MDR1 protein, or a homolog thereof. | 05-21-2009 |
20090118521 | NANOENGINEERED ORGANIC NONLINEAR OPTICAL GLASSES - Nonlinear optically active compounds having film-forming properties, films including the compounds, methods for making the compounds and films, and electro-optic devices including the films and compounds. | 05-07-2009 |
20090087469 | ALGINATE-BASED NANOFIBERS AND RELATED SCAFFOLDS - Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning. | 04-02-2009 |
20090065136 | FOAMING METHODS FOR MAKING CELLULAR THERMOPLASTIC MATERIALS - Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the foams made therefrom, and methods for altering the impact strength of solid or noncellular thermoplastic materials and the shaping of the materials into useful articles. | 03-12-2009 |
20090060846 | NANOPARTICLES HAVING REACTIVE ESTER GROUPS COVALENTLY COUPLED THERETO AND RELATED METHODS - A particle having a core and a surface to which are covalently coupled a plurality of reactive ester groups. Methods for using the particle to prepare a particle having one or more of a plurality of a targeting agent, a diagnostic agent, or a therapeutic agent covalently coupled thereto. | 03-05-2009 |
20090050199 | SEMICONDUCTING POLYMER FILMS WITH FIXED ELECTRONIC JUNCTIONS - A polymer film having fixed electronic junctions; devices that include the film; and methods for making and using the film. | 02-26-2009 |
20090042224 | METHODS FOR DIAGNOSIS AND/OR PROGNOSIS OF OVARIAN CANCER - In one embodiment, methods are provided for assessing the presence of mesothelin-expressing tumor cells in a human subject. In another embodiment, methods are provided for monitoring the efficacy of treatment of a human cancer patient diagnosed with a mesothelin-expressing tumor. | 02-12-2009 |
20090042213 | METHODS AND COMPOSITIONS FOR DETECTING THYROGLOBULIN IN A BIOLOGICAL SAMPLE - The invention provides a method and reagents for determining the presence and/or amount of human thyroglobulin in a biological sample. In one embodiment, the method comprises (a) digesting a biological sample containing proteins to provide peptide fragments; (b) contacting the digested sample with a binding reagent comprising a plurality of antibodies that are capable of binding to at least one thyroglobulin peptide fragment; and (c) determining the presence and/or amount of the thyroglobulin peptide fragments that are bound to the binding reagent. In some embodiments, the binding reagent comprises a plurality of antibodies capable of binding to at least one thyroglobulin peptide fragment set forth in TABLE 1. In some embodiments, the binding regent comprises a plurality of antibodies capable of binding to at least one thyroglobulin peptide selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:5. | 02-12-2009 |
20080287792 | Ultrasonic Direct Strain Estimation Using Temporal and Spatial Correlation - Strain is directly estimated in ultrasound elasticity imaging without computing displacement or resorting to spectral analysis. Conventional ultrasound elasticity imaging relies on calculating displacement and strain is computed from a derivative of the displacement. However, for typical parameter values used in ultrasound elasticity imaging, the displacement can be as large as a hundred times or displacement differences. If a tiny error in the calculation of displacement occurs, this could drastically affect the calculation of strain. By directly estimating strain, image quality is enhanced and the reduction in computational effort facilitates commercialization to aid in diagnosing disease or cancerous conditions. | 11-20-2008 |
20080283402 | SHAPED ELECTRODES FOR MICROFLUIDIC DIELECTROPHORETIC PARTICLE MANIPULATION - Methods, devices, and systems for separating disparate liquid-suspended particles in a flow channel using dielectrophoresis induced by concave-shaped electrodes and field-flow fractionation. | 11-20-2008 |
20080283401 | TIME-VARYING FLOWS FOR MICROFLUIDIC PARTICLE SEPARATION - Methods, devices, and systems for separating a time-varying flow of disparate liquid-suspended particles through a channel using dielectrophoresis and field-flow fractionation. | 11-20-2008 |
20080283385 | SPECTRALLY TUNABLE PHOTOLYSIS OF A CAPSULE CONTAINING AN ACTIVE MATERIAL - Capsules that include a shell, a sensitizer, and an active material. Methods for using the capsules to spatiotemporally deliver active material. Representative shells include vesicles, polymers, and inorganic materials. Representative active materials include small molecules and proteins. | 11-20-2008 |
20080280847 | PIT-1 AND VASCULAR CALCIFICATION - The present invention relates to methods and compositions comprising small interfering RNAs (siRNAs) to identify nucleotides encoding proteins involved in the co-transport of inorganic phosphate in vascular tissues. Specifically, it relates to the identification of Pit-1 and Pit-2 as key proteins involved in vascular calcification, the deposition of calcium phosphate, in blood vessels. The nucleic acids encoding specific siRNAs and vectors encoding these siRNAs are useful as tools to specifically inhibit the expression of Pit-1, Pit-2, or related proteins in various primary and stably-transformed cell lines, and as tools to explore the roles and functional relationships of these proteins involved in vascular calcification. In addition, they may be useful directly as therapeutic agents in humans delivered to sites of vascular calcification. | 11-13-2008 |
20080280123 | BIMODAL CELLULAR THERMOPLASTIC MATERIALS - Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the foams made therefrom, and methods for altering the impact strength of solid or noncellular thermoplastic materials and the shaping of the materials into useful articles. | 11-13-2008 |
20080279780 | Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer - A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate. | 11-13-2008 |
20080277817 | METHODS FOR ALTERING THE IMPACT STRENGTH OF NONCELLULAR THERMOPLASTIC MATERIALS - Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the foams made therefrom, and methods for altering the impact strength of solid or noncellular thermoplastic materials and the shaping of the materials into useful articles. | 11-13-2008 |
20080274346 | SOLID-STATE CELLULAR AND NONCELLULAR THERMOPLASTIC MATERIALS: PROCESSING, PROPERTIES, AND APPLICATIONS - Methods for reducing the density of thermoplastic materials and the articles made therefrom having similar or improved mechanical properties to the solid or noncellular material. Also disclosed are improvements to foaming methods and the cellular structures of the foams made therefrom, and methods for altering the impact strength of solid or noncellular thermoplastic materials and the shaping of the materials into useful articles. | 11-06-2008 |
20080234192 | COMPOSITIONS AND METHODS OF USE FOR TREATING CARDIOVASCULAR DISEASE - In one aspect, the present invention provides isolated oxidation resistant mutant apoA-I polypeptides comprising an amino acid sequence substantially homologous to SEQ ID NO:4, the mutant apoA-I polypeptide comprising a combination of: (1) a conservative amino acid substitution at residue Tyr192; and (2) at least one conservative amino acid substitution at residue Met86, Met112, or Met148, wherein the mutant apoA-I polypeptide is resistant to modification by an oxidizing agent. In another aspect, the invention provides a method of promoting cholesterol efflux activity in a mammalian subject in need thereof, the method comprising the step of administering an effective amount of an oxidation resistant apoA-I agonist to the subject to promote cholesterol efflux. | 09-25-2008 |
20080220531 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 09-11-2008 |
20080199957 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents. | 08-21-2008 |