Virginia Commonwealth University Patent applications |
Patent application number | Title | Published |
20160051815 | OLFACTORY IMPLANT SYSTEM - The system includes five components: (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The olfactory implant system generates odor fingerprints by detecting odors with an array of chemical sensors and then transmitting variable spatio-temporal stimulation patterns for an electrode array with electrode stimulating points positioned at different locations in the olfactory cortex (e.g., stimulating the olfactory bulb). Different patterns of activity in the olfactory cortex are thereby generated which mimic the sense of smell in a subject. Once trained the system should be usable by a subject to detect or correctly identify one or more odors. | 02-25-2016 |
20150320769 | Sulfated-Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Proliferation - Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S. | 11-12-2015 |
20150258204 | CLICKABLE POLYOXETANE CARRIER FOR DRUG DELIVERY - A polymer is provided, comprising a subunit having the formula: (I), wherein A, B, C, D, a, b, c, d, and p are defined herein. Compositions, methods of making, and methods of use are provided. | 09-17-2015 |
20150231177 | Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications - Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, H | 08-20-2015 |
20150196254 | HAPTIC GLUCOMETER GUIDE - A glucometer guide is provided to address the difficulty that blind or visually impaired diabetic patients have when attempting to independently use a glucometer. The guide provides haptic cues for the effective transfer of blood onto a test strip. | 07-16-2015 |
20150141416 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE - The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity. | 05-21-2015 |
20150087498 | Production of Graphene and Nanoparticle Catalysts Supported on Graphene Using Microwave Radiation - Microwave irradiation is used to synthesize graphene and metallic nanocatalysts supported on graphene either by solid or solution phase. In solid phase methods, no solvents or additional reducing agents are required so the methods are “environmentally friendly” and economical, and the graphene and nanocatalysts are substantially free of residual contaminants. Recyclable, high efficiency Pd nanocatalysts are prepared by these methods. | 03-26-2015 |
20150086578 | HUMAN CYTOMEGALOVIRUS VACCINE - Combination peptides, polypeptides and proteins that elicit high titer neutralizing antibodies against cytomegalovirus (CMV) are provided. The combination peptides, polypeptides and proteins encompass epitopes located within the UL130 and UL131 components of the gH/gL/UL128-131 protein complex, in particular, epitopes located within amino acid residues 27-46 of UL130 and amino acid residues 90-106 of UL131. The combination peptides, polypeptides and proteins, and the nucleic acids encoding them, may be used in vaccines, and as diagnostic and research tools. | 03-26-2015 |
20150065815 | ASSESSMENT AND PREDICTION OF CARDIOVASCULAR STATUS DURING CARDIAC ARREST AND THE POST-RESUSCITATION PERIOD USING SIGNAL PROCESSING AND MACHINE LEARNING - Real-time, short-term analysis of ECG, by using multiple signal processing and machine learning techniques, is used to determine counter shock success in defibrillation. Combinations of measures when used with machine learning algorithms readily predict successful resuscitation, guide therapy and predict complications. In terms of guiding resuscitation, they may serve as indicators and when to provide counter shocks and at what energy levels they should be provided as well as to serve as indicators of when certain drugs should be provided (in addition to their doses). For cardiac arrest, the system is meant to run in real time during all current resuscitation procedures including post-resuscitation care to detect deterioration for guiding care such as therapeutic hypothermia. | 03-05-2015 |
20150064208 | POLYVALENT CHIMERIC OSPC VACCINOGEN AND DIAGNOSTIC ANTIGEN - A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammaliran | 03-05-2015 |
20150040894 | Aerosolized Dapsone as a Therapy for Inflammation of the Airway and Abnormal Mucociliary Transport - Aerosolized dapsone (or alternatively, an aqueous formulation of dapsone) is used to treat airway inflammation, particularly chronic neutrophil-dominated inflammation. Diseases that may be prevented or treated by the methods include chronic obstructive pulmonary diseases (COPDs), asthma, cystic fibrosis, and others. | 02-12-2015 |
20150007817 | SYSTEMS, DEVICES, AND METHODS FOR CHANGING THERAPEUTIC AEROSOL SIZE AND IMPROVING EFFICIENCY OF VENTILATION AND AEROSOL DRUG DELIVERY - A mixer-heater device provides controllable reduction in aerosol droplet size. Additionally, an intermittent delivery mode for administering an aerosol to a patient may take into account patient expiration and reduce aerosol losses without prolonging treatment time. Depositional losses in aerosol delivery systems may be reduced by streamlining the three dimensional geometry of conduits which change stream direction or flow path diameter. Ventilation systems may also benefit from streamlined components, in particular Y-connectors, with resulting advantages such as reduced rebreathed CO | 01-08-2015 |
20140357656 | Bivalent Ligands for the Treatment of Neurological Disorders - Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS. | 12-04-2014 |
20140302267 | ABHESIVE COATINGS - A monolithic, self-stratifying polymer coating, comprising: inner and outer-most surfaces on opposite sides of the coating, the inner surface being in contact with and adhered to an article; a surface region, extending from the outermost surface to a depth of about 2 nm from the outermost surface; a middle region, extending from a depth of about 2 nm from the outermost surface to a depth of less than about 2000 nm from the outermost surface; and a bulk region, extending from a depth of less than about 2000 nm from the outermost surface to the inner surface; wherein the surface region comprises a fluorous polyoxetane having the formula: (I) wherein n is an integer of 0-1 1, and m is an integer>0, in a greater concentration relative to the middle and bulk regions; wherein the middle region comprises 3F-SiO | 10-09-2014 |
20140248640 | METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS, DENDRITIC CELLS AND FOLLICULAR DENDRITIC CELLS - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 09-04-2014 |
20140220536 | Computer Implemented Methods, Systems and Products for Team Based Learning - Computer implemented methods, systems, and products uses learning cycles of individual and group work to emphasize the importance of collaborative behaviors and demonstrate the values of effective team work on outcomes. The computer implemented methods, systems, and products relate to team based learning with individual and group assessment for addressing a project or a problem, particularly to promote interaction between participants. In the computer implemented learning cycle, a team works as individuals and then as a group to determine responses to an overall project or problem. In addition to assessing the performance of the individuals and the determined individualized and overall responses, the computer implemented methods, systems, and products track the progress and activity of individuals and the team. Through the cycle of learning activities, individuals demonstrate personal responsibility, collaborative orientation, communication skills, conflict management, and problem solving. | 08-07-2014 |
20140212451 | Lyme Disease Vaccine - Antigenic polypeptides comprising linear immunodominant epitopes of | 07-31-2014 |
20140179726 | GUT MICROFLORA AS BIOMARKERS FOR THE PROGNOSIS OF CIRRHOSIS AND BRAIN DYSFUNCTION - A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and/or to develop and monitor the outcome of therapeutic treatments. An exemplary disease/condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis. | 06-26-2014 |
20140147506 | Delivery of Submicrometer and Nanometer Aerosols to the Lungs using Hygroscopic Excipients or Dual Stream Nasal Delivery - Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung. | 05-29-2014 |
20140080904 | Cinnamic Acid-Based Oligomers and Uses Thereof - Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants. | 03-20-2014 |
20140065139 | Induction of Tumor Hypoxia for Cancer Therapy - Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced. | 03-06-2014 |
20140059279 | SSD Lifetime Via Exploiting Content Locality - A solid state drive (SSD), which is used in computing systems, implements the systems and methods of a Delta Flash Transition Layer (ΔFTL) to store compressed data in the SSD instead of original new data. The systems and methods of ΔFTL reduce the write count via exploiting the content locality between the write data and its corresponding old version in the flash. Content locality implies the new version resembles the old to some extent, so that the difference (delta) between the versions may be compressed compactly. Instead of storing new data in its original form in the flash, ΔFTL stores the compressed deltas. | 02-27-2014 |
20130338033 | Diagnostic and Prognostic Markers for Metastasis - Methods for monitoring cancer metastasis and/or monitoring the response of a patient to cancer therapy directed against metastatic cancer are provided. The methods involve measuring Insulin Growth Factor Binding Protein-2 (IGFBP-2) and/or other biomarkers in biological (e.g., blood, plasma, serum) samples from the patient. | 12-19-2013 |
20130310779 | TREATMENT FOR HIGH PRESSURE BLEEDING - High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices. | 11-21-2013 |
20130309213 | COMPOSITION AND METHOD FOR IMMUNOLOGICAL TREATMENT OF CANCER, PREVENTION OF CANCER RECURRENCE AND METASTASIS, AND OVERCOMING IMMUNE SUPPRESOR CELLS - Methods for the ex vivo generation of cells of the innate (NKT cells and NK cells) and adaptive (T cells) immune systems for use in adoptive cell transfer (ACT) are provided. The NKT cells render T cells resistant to immune suppression (e.g. they are resistant to the effects of myeloid-derived suppressor cells (MDSCs)). The method involves culturing disease-primed immune cells (obtained from a cancer patient or from a patient with an infectious disease) with i) byrostatin and ionomycin (B/I) to activate and differentiate the cells; followed by sequentially culturing the cells with a) a combination of IL-7 and IL-15 and then b) IL-2, to further differentiate the cells and to render them immune resistant. The resistant immune cells are used to treat and prevent cancer and infectious diseases. | 11-21-2013 |
20130289471 | GAS BASED WOUND AND TISSUE THERAPEUTICS - This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue. | 10-31-2013 |
20130266668 | USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES - Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas such as NO, CO, H | 10-10-2013 |
20130266664 | FACILE METHOD FOR CROSSLINKING AND INCORPORATING BIOACTIVE MOLECULES INTO ELECTROSPUN FIBER SCAFFOLDS - Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the cross-linking linking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner. | 10-10-2013 |
20130266606 | POLYVALENT CHIMERIC OSPC VACCINOGEN AND DIAGNOSTIC ANTIGEN - A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammalian | 10-10-2013 |
20130263296 | CANCER IMAGING WITH THERAPY: THERANOSTICS - Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided. | 10-03-2013 |
20130195859 | Compositions and methods for modulating cardiac conditions - Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof. | 08-01-2013 |
20130178949 | AIR IMPEDANCE ELECTROSPINNING FOR CONTROLLED POROSITY - Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering. | 07-11-2013 |
20130164289 | HUMAN CYTOMEGALOVIRUS VACCINE - Combination peptides, polypeptides and proteins that elicit high titer neutralizing antibodies against cytomegalovirus (CMV) are provided. The combination peptides, polypeptides and proteins encompass epitopes located within the UL130 and UL131 components of the gH/gL/UL128-131 protein complex, in particular, epitopes located within amino acid residues 27-46 of UL130 and amino acid residues 90-106 of UL131. The combination peptides, polypeptides and proteins, and the nucleic acids encoding them, may be used in vaccines, and as diagnostic and research tools. | 06-27-2013 |
20130156866 | HYPERHALOGENS AND HIGHLY ELECTRONEGATIVE COMPOSITIONS - Hyperhalogens, a new class of highly electronegative species, are now invented. A hyperhalogen is a superhalogen-containing composition in which the electron affinity (EA) of the hyperhalogen is even larger than that of the superhalogens they are composed of. Novel production methods are provided in which highly electronegative species are produced by surrounding a central metal atom by superhalogen moieties. | 06-20-2013 |
20130156705 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING A[BETA] OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE - Bivalent multifunctional Aβ oligomerization inhibitors (BMAOIs) that target multiple risk factors involved in Alzheimer's disease are provided. The BMAOIs are useful for the treatment and/or prevention of Alzheimer's disease, as well as for diagnostic imaging of Aβ plaques in brain tissue. The BMAOIs comprise i) an Aβ oligomer (ApO)-inhibitor moiety which may have antioxidant activity (e.g. curcumin, curcumin derivatives, curcumin hybrids, resveratrol, etc.); ii) a cell membrane/lipid raft (CM/LR) anchoring moiety (e.g. cholesterol, cholesterylamine, a steroid, etc.); and iii) a spacer or linker moiety that stably links i) | 06-20-2013 |
20130150357 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE - The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity. | 06-13-2013 |
20130143854 | NUCLEAR SULFATED OXYSTEROL, POTENT REGULATOR OF LIPID HOMEOSTASIS, FOR THERAPY OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDES, FATTY LIVER DISEASES, AND ATHEROSCLEROSIS - The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided. | 06-06-2013 |
20130089880 | Method for Diagnosing Acute Cardiac Ischemia - Chemiluminescent detection of metabolic by-products of inosine and hypoxanthine to diagnose ischemic events such as early acute cardiac ischemia. | 04-11-2013 |
20120195935 | MICROBUBBLE ASSISTED VIRAL DELIVERY - Microbubble-assisted delivery of viruses is disclosed. In particular, methods for targeting a virus to cancer cells in an immunocompetent animal by administering a selectively replicating virus to the immunocompetent animal and disrupting the microbubbles in a location of the animal comprising cancer cells are provided. The virus is encompassed in a suspension of microbubbles, and the surface of the suspension does not include any virus. A suspension of microbubbles comprising a selectively replicating virus that is encompassed in a suspension of microbubbles, which does not include any virus on the surface of the suspension, is also provided. | 08-02-2012 |
20110313028 | SUPPRESSOR OF AP-1 - Methods, compositions, and therapeutic products for use in the field of oncology and specifically, for the treatment of cancer and other diseases in which SARI is ameliorative or therapeutic and/or small molecule screening for anti-cancer drugs are provided. Cancer specific gene expression using the CCN1 promoter, which is negatively regulated by SARI, for targeting therapeutic molecules in tumors is also provided. | 12-22-2011 |
20110060578 | COMPREHENSIVE MODELING OF THE HIGHLY NETWORKED COAGULATION-FIBRINOLYSIS-INFLAMMATORY-IMMUNE SYSTEM - An agent-based modeling system (ABMS) is employed to quantitatively analyze individual components of each system of the coagulation-immune/inflammatory-fibrinolysis system at every point of simulation. ABMS is a dynamic modeling and simulation tool that allows the study of dynamic non-linear networked systems. ABMS represents a non-reductionist approach of studying the biologic process as a whole, while retaining information at the level of an individual component. | 03-10-2011 |
20110009291 | METHODS AND COMPOSITIONS FOR INCREASING MEMBRANE PERMEABILITY - Methods and compositions for increasing membrane permeability are provided. One aspect provides protein resulting from a fusion between a membrane-active peptide and second peptide. Nucleic acids and vectors encoding the pore forming fusion proteins are also provided. | 01-13-2011 |
20100291058 | Sealants for Skin and Other Tissues - The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants. | 11-18-2010 |
20090155342 | Mineral technologies (MT) for acute hemostasis and for the treatment of acute wounds and chronic ulcers - Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided. | 06-18-2009 |
20090149748 | Portable Pulmonary Injury diagnostic Devices And Methods - Lung injury such as pneumothorax now can be diagnosed reliably, portably and quickly. Vibro-acoustic waves are sent through the chest and the resulting wave is measured. By analyzing attenuation characteristics determined by the geometry of the chest structures, a determination can be made of whether the patient's pleural space is healthy, contains air (pneumothorax) or contains fluid (hemothorax). | 06-11-2009 |
20090104221 | RAPID GENERATION OF T CELL-INDEPENDENT ANTIBODY RESPONSES TO T CELL-DEPENDENT ANTIGENS - The present invention comprises the use of follicular dendritic cells (FDCs) or FDC-like cells to generate FDC-dependent, but T cell-independent, B cell responses to T cell-dependent antigens, with antigen-specific and polyclonal antibody production in ˜48 h. In another embodiment, a germinal center (GC) lymphoid tissue equivalent (LTE) was used to generate antigen-specific IgM, followed by switching to IgG. The GC LTE model can be used in vaccine assessment. Dual forms of immunogen were used in the GC LTE and in vivo. Dual immunogens resulted in rapid, specific IgM responses and enhanced IgG responses. This vaccine design approach can be used, for example, to provide rapid IgM protection (˜24-48 h) and high-affinity IgG more quickly in people moving to areas with endemic disease, or in people with T cell insufficiencies, who can be immunized to rapidly generate protective IgM. | 04-23-2009 |
20080280781 | Methods and Compositions for Increasing Membrane Permeability - Methods and compositions for increasing membrane permeability are provided. One aspect provides protein resulting from a fusion between a membrane-active peptide and second peptide. Nucleic acids, and vectors encoding the, pore forming fusion proteins are also provided. | 11-13-2008 |