| UNIVERSITY OF SOUTHERN CALIFORNIA Patent applications |
| Patent application number | Title | Published |
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| 20220257655 | ENGINEERED OFF-THE-SHELF IMMUNE CELLS AND METHODS OF USE THEREOF - Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered immune cells. Certain embodiments of the disclosure include compositions, cells, and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and may be suitable for allogeneic cellular therapy because they are HLA negative. In some aspects, the cells have imaging and suicide targeting capabilities. | 08-18-2022 |
| 20220247039 | LONG-LIFE LITHIUM-SULFUR BATTERY USING A NOVEL FLEXIBLE BI-LAYER SOLID STATE ELECTROLYTE - A lithium-sulfur battery cell includes a cathode that includes sulfur, an anode that includes lithium metal; and a bilayer membrane interposed between the cathode and the anode. The bilayer membrane includes a mixed conduction membrane layer and a lithium ion-conducting polymer electrolyte layer where the lithium ion-conducting layer is interposed between the mixed conduction membrane layer and the anode. | 08-04-2022 |
| 20220229912 | SYSTEMS AND METHODS FOR A TEXT MINING APPROACH FOR PREDICTING EXPLOITATION OF VULNERABILITIES - Various embodiments of a computer-implemented framework for predicting exploitation of software vulnerabilities are disclosed. | 07-21-2022 |
| 20220216922 | OPTICAL PHASED ARRAY RECEIVER ARCHITECTURES - Described herein are optical phased array receivers. In various embodiments, an optical phased array receiver includes a set of antennas, each antenna configured to receive an optical signal; a local oscillator configured to generate one or more optical carrier signals; one or more optical signal combiners coupled to the set of antennas and the local oscillator, the one or more optical signal combiners configured to combine (i) the optical signals received by the antennas and (ii) the optical carrier signal; and one or more photodetectors configured to extract information carried by one or more of the received optical signals into an electrical signal, wherein the extracted information is indicative of a phase and an amplitude of the one or more of the received optical signals. | 07-07-2022 |
| 20220098739 | OXYGEN-GENERATING BIOELECTRICAL REACTOR - In various embodiments of the present disclosure, an oxygen-generating bioelectrical reactor comprises two chambers, a first oxidative chamber configured for the abiotic oxidation of water to generate molecular oxygen, and a second reductive chamber configured for the biotic reduction of an insoluble metal(loid) oxide or hydroxide. In various embodiments, the biotic reduction comprises microbially-catalyzed metal(loid) ion reduction of the insoluble metal(loid) oxide or hydroxide, wherein a dissimilatory metal(loid) reducing microorganism transfers electrons obtained from the oxidation of the water extracellularly to the metal(loid) ions. | 03-31-2022 |
| 20210382479 | Systems and Methods for Controlling Automated Systems Using Integer Programming and Column Generation Techniques - Systems and methods for controlling automated systems, such as robots and other devices/resources, using integer programming and column generation techniques, are provided. The system retrieves location and movement data corresponding to at least one automated system, and processes the location and movement data using an integer linear programming algorithm. The system also optimizes the integer linear programming algorithm using a column generation algorithm, and solves a pricing problem associated with generating routes for the at least one automated system. Then, the system generates a route based on outputs of the integer linear programming algorithm, the column generation algorithm, and solving of the pricing problem, and transmits the route to the at least one automated system, the at least one automated system executing the route to control a location or a movement of the at least one automated system. | 12-09-2021 |
| 20210371479 | MENTSH ANALOGS AS THERAPEUTICS FOR DIABETES, OBESITY, AND THEIR ASSOCIATED DISEASES AND COMPLICATIONS - Described herein is a novel, mitochondrial encoded, open reading frame, that leads to the production of a new mitochondrial peptide. Residing within the ND-Two subunit, a specific small nucleotide polymorphism disrupts expression of this mitochondrial peptide, and is correlated with an increase in obesity and diabetes, particularly in certain ethnic populations. In vitro administration of the peptide increases insulin secretion, decreases fat accumulation and improves glucose uptake in muscle cell. Antibodies generated against the peptide can be used for detecting peptide deficiency, in addition to SNP detection, supporting diagnostic approaches. In vivo studies further revealed that administration of the peptide improves glucose tolerance, thereby providing a new therapeutic avenue for a novel diabetes therapy and decreases bodyweight, thus serving as a novel obesity therapy. Generation of synthetic analogs further enhance or abrogated activity relative to the natural peptide. | 12-02-2021 |
| 20210347709 | RADIOFLUORINATED GPC3-BINDING PEPTIDES FOR PET IMAGING OF HEPATOCELLULAR CARCINOMA - The invention provides a radiopharmaceutical compound or composition comprising a radiolabeled linear peptide that binds specifically to Glypican-3 (GPC3) expressed on a surface of a cell. Preferably, the linear peptide is conjugated to one or more | 11-11-2021 |
| 20200409177 | CONTACT LENS WITH METERED LIQUID SYSTEM - A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid. | 12-31-2020 |
| 20200292579 | Multi-Layer, Multi-Material Micro-Scale and Millimeter-Scale Devices with Enhanced Electrical and/or Mechanical Properties - Some embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes for use in die level testing of semiconductor devices) from a core material and a shell or coating material that partially coats the surface of the structure. Other embodiments are directed to electrochemical fabrication methods for producing structures or devices (e.g. microprobes) from a core material and a shell or coating material that completely coats the surface of each layer from which the probe is formed including interlayer regions. Additional embodiments of the invention are directed to electrochemical fabrication methods for forming structures or devices (e.g. microprobes) from a core material and a shell or coating material wherein the coating material is located around each layer of the structure without locating the coating material in inter-layer regions. | 09-17-2020 |
| 20200090071 | USING NOISE TO SPEED CONVERGENCE OF SIMULATED ANNEALING AND MARKOV MONTE CARLO ESTIMATIONS - The invention shows how to use noise-like perturbations to improve the speed and accuracy of Markov Chain Monte Carlo (MCMC) estimates and large-scale optimization, simulated annealing optimization, and quantum annealing for large-scale optimization. | 03-19-2020 |
| 20190270762 | NOVEL BROAD SPECTRUM ANTIVIRAL COMPOUNDS - An antiviral compound of the following formula (I) is provided or a salt or a pharmaceutically acceptable salt thereof, where B is a naturally occurring or non-naturally occurring base; R | 09-05-2019 |
| 20180371506 | Method and Apparatus for CO2 Sequestration - Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO | 12-27-2018 |
| 20180159171 | LITHIUM-ION MIXED CONDUCTOR MEMBRANE IMPROVES THE PERFORMANCE OF LITHIUM-SULFUR BATTERY AND OTHER ENERGY STORAGE DEVICES - A lithium ion mixed conduction membrane includes an optional polymeric binder and a partially lithiated ion conductive material having lithium ion conductivity and electrical conductivity dispersed within the polymeric binder that is capable of improving the performance and cycle life of lithium-sulfur rechargeable batteries and other batteries exhibiting the polysulfide shuttle. One or more lithium ion conduction membranes are placed between the positive and negative electrodes, or adjacent to the negative electrode of a battery and in particular, of a lithium sulfur battery. | 06-07-2018 |
| 20180104281 | HIGH TELMERASE ACTIVITY BONE MARROW MESENCHYMAL STEM CELLS, METHODS OF PRODUCING THE SAME AND PHARMACEUTICALS AND TREATMENT METHODS BASED THEREON - Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34+ bone marrow mesenchymal stem cells. Also disclosed are bone marrow mesenchymal stem cells treated with a telomerase induction agent. | 04-19-2018 |
| 20170260592 | NEXT GENERATION RNA-SEQUENCING AND LONG NON-CODING RNA IN GLIOBLASTOMA MULTIFORME - LncRNAs are emerging as important oncogenic drivers in many cancers, but comprehensive, agnostic studies to identify key lncRNAs involved in GBM are lacking. Described herein are new lncRNA involved in gliomagenesis and prognosis, elucidating the biological functions of these relatively unknown biological actors and opening new therapeutic avenues for therapeutic development. | 09-14-2017 |
| 20170174638 | COMPOUNDS AND METHODS FOR INHIBITING VACUOLAR ATPASE - A compound of Formula II, | 06-22-2017 |
| 20170162876 | Coating Particles - A method includes combining a coating material and an uncoated particulate core material in a solution having a selected ionic strength. The selected ionic strength promotes coating of the uncoated particulate core material with the coating material to form coated particles; and the coated particles can be collected after formation. The coating material has a higher electrical conductivity than the core material. | 06-08-2017 |
| 20170151610 | INSERTING INHIBITOR TO CREATE PART BOUNDARY ISOLATION DURING 3D PRINTING - A 3D printing system may print a desired 3D object. A fusible powder may fuse when subjected to a fusing condition. A deposition system may deposit portions of the fusible powder on a substrate. A fusing system may apply the fusing condition to the deposited fusible powder. Inhibitor material may not fuse when subjected to the fusing condition. An insertion system may insert a portion of the inhibitor material between portions of the deposited fusible powder after having been deposited by the deposition system, but before being fused by the fusing system, so as to form a boundary that defines at least a portion of a surface of the desired 3D object. | 06-01-2017 |
| 20170020387 | OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM WITH PHASE-SENSITIVE B-SCAN REGISTRATION - This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans, and align B-scans, thereby minimizing effects of motion that may occur during scanning of the physical object. | 01-26-2017 |
| 20160333420 | GENE EXPRESSION PANEL FOR PROGNOSIS OF PROSTATE CANCER RECURRENCE - Disclosed is a gene expression panel that can be used to predict prostate cancer (PCa) progression. Some embodiments provide methods for predicting clinical recurrence of PCa. Some embodiments provide a method for predicting progression of prostate cancer in an individual, the method comprising: (a) receiving expression levels of a collection of signature genes from a biological sample taken from said individual, wherein said collection of signature genes comprises at least two genes selected from the group consisting of: NKX2-1, UPK1A, ADRA2C, ABCC11, MMP11, CPVL, ZYG11A, CLEC4F, OAS2, PGC, UPK3B, PCBP3, ABLIM1, EDARADD, GPR81, MYBPC1, F10, KCNA3, GLDC, KCNQ2, RAPGEF1, TUBB2B, MB, DUOXA1, C2orf43, DUOX1, PCA3 and NPR3; (b) applying the expression levels to a predictive model relating expression levels of said collection of signature genes with prostate cancer progression; and (c) evaluating an output of said predictive model to predict progression of prostate cancer in said individual. Systems are also provided for predicting progression and/or recurrence of PCa. | 11-17-2016 |
| 20160331227 | EXTENDED DURATION OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM - This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. These systems may allow OCT scanning for an extended duration and generation of large field OCT images suitable for the OCT angiography. | 11-17-2016 |
| 20160297802 | CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS | 10-13-2016 |
| 20160145344 | MURINE AND HUMAN INNATE LYMPHOID CELLS AND LUNG INFLAMMATION - Described herein are methods and compositions for treatment of inflammation, such as inflammation in lung and/or airway tissue, including asthma Innate lymphoid cells (ILCs), such as type 2 ILC2s, are herein described as capable of IL-33 signaling activation, leading to airway hyperresponsiveness (AHR) and inflammation. Further described is the hereto unknown discovery that ICOS-ligand is expressed in ILC2s, that ICOS binding of ICOS to ICOS-ligand is required for its function in ILC2s, and that while IL-33 treatment induces AHR in control mice, IL-33 cannot induce AHR in mice receiving treatment via anti-ICOS-ligand antibodies. These results suggest new methods and compositions targeting ICOS and ICOS-ligand, such as dual specific antibodies that recognize ICOS and ICOS-ligand, an expression profile unique to ILC2s. | 05-26-2016 |
| 20160142133 | Methods, Systems and Devices for Optical-Signal-to-Noise-Ratio Monitoring - A device for optical-signal-to-noise (OSNR) monitoring can include: a delay-line interferometer configured to connect with a tunable optical filter; and two or more power detectors to measure outputs of the interferometer; wherein one or more parameters are optimized for different transmission baud rates to improve accuracy. In addition, a method can include: connecting an input of a delay-line interferometer with an output of a tunable optical filter, and an output of the delay-line interferometer with an input of a power detector, to form an optical-signal-to-noise (OSNR) monitoring apparatus; optimizing one or more parameters of the OSNR monitoring apparatus for different transmission baud rates to improve accuracy. | 05-19-2016 |
| 20160136146 | COMPOSITIONS AND METHODS FOR TREATING PRIMARY EFFUSION LYMPHOMA - Methods for treating primary effusion lymphoma (PEL) are provided. The methods include administering to a patient in need thereof an effective amount of an immunomodulatory compound. Suitable immunomodulatory compounds include compounds having the formula: | 05-19-2016 |
| 20160130643 | ACCURATE IN VITRO COPYING OF DNA METHYLATION - A method of copying a methylated nucleic acid molecule is provided. The method includes copying a nucleic acid molecule into a plurality of nucleic acid molecules; and contacting the plurality of nucleic acid molecules with a DNA methyltransferase enzyme and an E3 ubiquitin ligase. The method results in the copying of the methylated nucleic acid molecule. | 05-12-2016 |
| 20160129043 | COMPOSITION OF MESENCHYMAL STEM CELLS - This invention relates in general to a mesenchymal stem cell (MSC) therapy. This invention further relates to the isolation and applications of gingiva derived mesenchymal stem cells. More particularly, this invention relates to the isolation and applications of the neural crest derived gingiva mesenchymal stem cells and/or mesoderm derived gingiva mesenchymal stem cells. This invention also relates to a composition comprising a neural crest derived gingiva mesenchymal stem cell and/or a mesoderm derived gingiva mesenchymal stem cell. This composition may be used for wound healing and/or in the treatment of inflammatory and/or autoimmune diseases. | 05-12-2016 |
| 20160109726 | CONTACT LENS WITH METERED LIQUID SYSTEM - A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid. | 04-21-2016 |
| 20160106781 | HIGH TELOMERASE ACTIVITY BONE MARROW MESENCHYMAL STEM CELLS, METHODS OF PRODUCING THE SAME AND PHARMACEUTICALS AND TREATMENT METHODS BASED THEREON - Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34 | 04-21-2016 |
| 20160106770 | EPIGENETIC MECHANISMS OF ANTI-FIBROTIC ACTION FOR THE LIVER - This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis. | 04-21-2016 |
| 20160083956 | CONTOUR CRAFTING EXTRUSION NOZZLES - An automated extrusion construction system may include an extrusion nozzle configured to extrude construction material in a substantially horizontal direction against an elongated and substantially vertical surface. An extrusion nozzle may have a height adjustment mechanism configured to adjust the height of an outlet in response to level deviations in the surface on which the construction material is extruded by the extrusion nozzle. An automated extrusion construction system may include a slicing mechanism configured to controllably slice through the extruded layer. | 03-24-2016 |
| 20160067464 | METHOD AND SENSOR FOR DETECTING CATHETER OBSTRUCTION - A self-monitoring catheter system may detect an obstruction during use of a catheter. The system may include a catheter with an interior lumen that has one or more ports into the lumen; a first and a second electrode; and an impedance measurement instrument that measures changes in the impedance between the first and the second electrodes after the first electrode is exposed to fluid within the catheter lumen, thereby signaling an obstruction during use of the catheter. | 03-10-2016 |
| 20160053003 | COMPOSITIONS AND METHODS FOR TREATING HIF-1a OVER-EXPRESSING CANCERS - Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90α or VKHFSVEGQ in Hsp90α. | 02-25-2016 |
| 20160046076 | STATISTICAL PREDICTIVE MODELING AND COMPENSATION OF GEOMETRIC DEVIATIONS OF 3D PRINTED PRODUCTS - A non-transitory, tangible, computer-readable storage media may contain a program of instructions that causes a computer system having a processor running the program of instructions to: receive design information indicative of the design of a three-dimensional object to be printed by a three-dimensional printer; receive test product deformation information indicative of deformation in the profiles of no more than five, three-dimensional test products that have a circular or polygonal cross section that were made by the three-dimensional printer; generate polygon product deformation information indicative of a predicted deformation of a polygon shape that the three-dimensional printer will print and that has a number of sides and a number of sizes that are both different from each of the number of sides and number of sizes that the no more than five, three-dimensional test products have; and generate adjustment information indicative of an adjustment needed to print a desired profile of the polygon shape that the three-dimensional printer will print to make the printed shape accurate | 02-18-2016 |
| 20160034814 | NOISE-BOOSTED BACK PROPAGATION AND DEEP LEARNING NEURAL NETWORKS - A learning computer system may update parameters and states of an uncertain system. The system may receive data from a user or other source; process the received data through layers of processing units, thereby generating processed data; process the processed data to produce one or more intermediate or output signals; compare the one or more intermediate or output signals with one or more reference signals to generate information indicative of a performance measure of one or more of the layers of processing units; send information indicative of the performance measure back through the layers of processing units; process the information indicative of the performance measure in the processing units and in interconnections between the processing units; generate random, chaotic, fuzzy, or other numerical perturbations of the received data, the processed data, or the one or more intermediate or output signals; update the parameters and states of the uncertain system using the received data, the numerical perturbations, and previous parameters and states of the uncertain system; determine whether the generated numerical perturbations satisfy a condition; and if the numerical perturbations satisfy the condition, inject the numerical perturbations into one or more of the parameters or states, the received data, the processed data, or one or more of the processing units. | 02-04-2016 |
| 20160028479 | Adaptive Optics Based Simultaneous Turbulence Compensation of Multiple Orbital Angular Momentum Beams - An adaptive optics compensation approach for an OAM multiplexed FSO communication system is described, in which a Gaussian beam is used to probe the turbulence-induced wavefront distortions and derive the correction pattern for compensating the OAM beams. Using this approach, we demonstrate simultaneous compensation of multiple OAM beams each carrying a 100-Gbit/s data channel through emulated atmospheric turbulence. The results indicate that the turbulence-induced crosstalk and power penalty could be efficiently mitigated by ˜12.5 dB and ˜11 dB respectively. | 01-28-2016 |
| 20160020418 | STABLE ORGANIC PHOTOSENSITIVE DEVICES WITH EXCITON-BLOCKING CHARGE CARRIER FILTERS UTILIZING HIGH GLASS TRANSITION TEMPERATURE MATERIALS - Disclosed herein are stable organic photosensitive devices including at least one exciton-blocking charge carrier filter. The filters comprise a mixture of at least one wide energy gap material having a sufficiently high glass transition temperature, e.g., higher than the temperature or temperature range at which the device typically operates, higher than a highest operating temperature of the device, higher than a threshold temperature value, etc. and at least one electron or hole conducting material. As described herein, the novel filters simultaneously block excitons and conduct the desired charge carrier (electrons or holes). | 01-21-2016 |
| 20160019459 | NOISE-ENHANCED CONVOLUTIONAL NEURAL NETWORKS - A learning computer system may include a data processing system and a hardware processor and may estimate parameters and states of a stochastic or uncertain system. The system may receive data from a user or other source; process the received data through layers of processing units, thereby generating processed data; apply masks or filters to the processed data using convolutional processing; process the masked or filtered data to produce one or more intermediate and output signals; compare the output signals with reference signals to generate error signals; send and process the error signals back through the layers of processing units; generate random, chaotic, fuzzy, or other numerical perturbations of the received data, the processed data, or the output signals; estimate the parameters and states of the stochastic or uncertain system using the received data, the numerical perturbations, and previous parameters and states of the stochastic or uncertain system; determine whether the generated numerical perturbations satisfy a condition; and, if the numerical perturbations satisfy the condition, inject the numerical perturbations into the estimated parameters or states, the received data, the processed data, the masked or filtered data, or the processing units. | 01-21-2016 |
| 20160017004 | METHODS AND THERAPEUTICS COMPRISING LIGAND-TARGETED ELPs - Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (ELP) component and a ligand selected from the group consisting of mIgA and knob capable of either drug encapsulation or drug attachment. Further aspects relate to drug delivery systems comprising an elastin-like peptide (ELP) component and a ligand; wherein the ligand specifically binds to a receptor selected from the group consisting of CAR and pIgR. Further aspects include the novel transcytosing properties of the elastin-like peptide and the ligand, knob. Also provided are methods and pharmaceutical compositions comprising the disclosed therapeutics. | 01-21-2016 |
| 20160005983 | ORGANIC PHOTOSENSITIVE DEVICES COMPRISING ARYL SQUARAINES AND METHODS OF MAKING THE SAME - There is disclosed squaraine compounds of formula I: | 01-07-2016 |
| 20160005399 | NOISE SPEED-UPS IN HIDDEN MARKOV MODELS WITH APPLICATIONS TO SPEECH RECOGNITION - A learning computer system may estimate unknown parameters and states of a stochastic or uncertain system having a probability structure. The system may include a data processing system that may include a hardware processor that has a configuration that: receives data; generates random, chaotic, fuzzy, or other numerical perturbations of the data, one or more of the states, or the probability structure; estimates observed and hidden states of the stochastic or uncertain system using the data, the generated perturbations, previous states of the stochastic or uncertain system, or estimated states of the stochastic or uncertain system; and causes perturbations or independent noise to be injected into the data, the states, or the stochastic or uncertain system so as to speed up training or learning of the probability structure and of the system parameters or the states. | 01-07-2016 |
| 20160000880 | Methods for Treating Multiple Sclerosis - The present invention provides methods for treating or limiting development of multiple sclerosis by administering angiotensin peptides to a subject with multiple sclerosis or at risk of developing multiple sclerosis. | 01-07-2016 |
| 20160000743 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF OPHALMIC DISEASES AND DISORDERS - This invention provides compounds, methods and compositions for the treatment of ophthalmic diseases and disorders, including retinal and choroidal disorders and related conditions. More particularly, the invention provides a method of using the provided pharmaceutical compositions for the treatment of ophthalmic diseases and disorders, including retinal and choroidal diseases, and related conditions, upon topical administration to the eye. | 01-07-2016 |
| 20150380738 | Free-Standing Active Material/Carbon Nanomaterial Network Film As Light-Weight and High-Power Electrodes for Lithium Ion Batteries - An electrode includes a first free-standing carbon network, an active material deposited above the first free-standing carbon network, and a second free-standing carbon network covering the active material. The first and second carbon networks are a binder, a conductive additive and a current collector to the electrode. | 12-31-2015 |
| 20150366707 | SMALL MOLECULE TRANSPORT DEVICE FOR DRUG DELIVERY OR WASTE REMOVAL - A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body. | 12-24-2015 |
| 20150363948 | Direct Patlak Estimation from List-Mode PET Data - A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data processing system. The three dimensional positron emission tomography (3D PET) scanner may: perform scans of the subject at each of multiple bed positions, each scan being of only a sub-portion of the subject that is within an axial length covered by the scanner; and generate dynamic list-mode PET data that: represents a total number of photon pairs arriving at each of multiple detector pairs in the 3D PET scanner; and is organized in a list of elements, each element in the list including a detector pair index and an arrival time for each detected photon pair; and acquires PET data using a dynamic PET protocol with at least two scans at each of the multiple bed positions. The data processing system may: reconstruct Patlak slope and intercept images of the subject over an axial length of the subject that exceeds the axial length of each scan of the subject by optimizing a likelihood or penalized likelihood function using the list-mode PET data from at least two scans of the subject at each of the multiple bed positions; and store the reconstructed image in a storage device or displays the reconstructed image on a display system. | 12-17-2015 |
| 20150356767 | RAPID AVATAR CAPTURE AND SIMULATION USING COMMODITY DEPTH SENSORS - A non-transitory, tangible, computer-readable storage medium may contain a program of instructions that cause a computer system running the program of instructions to automatically generate a 3D avatar of a living being, including automatically: causing one or more sensors to generate 3D data indicative of the three dimensional shape and appearance of at least a portion of the living being; and generating a virtual character based on the 3D data that can be animated and controlled. | 12-10-2015 |
| 20150355465 | HEAD MOUNTED DISPLAY FRAME FOR IMPROVED SPATIAL PERFORMANCE IN HEAD MOUNTED VIRTUAL ENVIRONMENTS - A head-mounted display allows the user to view a virtual environment. The head-mounted display is made of a pair of lenses which is directed to a display encased within a housing. However, the display provides a limited field-of-view that is less than what the user sees in a real-world environment. Adding an illuminated frame around the display's periphery can enable the user to produce spatial judgment similar to having a larger field-of-view. The illuminated frame does not require additional processing. | 12-10-2015 |
| 20150352550 | DISCRETE ELEMENTS FOR 3D MICROFLUIDICS - A module may be provided with at least one opening, the opening being an endpoint of a microfluidic channel that passes through at least part of the module. A set of multiple such modules may be arranged into an arrangement of modules, which may be coupled together using one or more coupling mechanisms included on each module. The arrangement of modules may fit within a regular polyhedral grid, and each module within the arrangement of modules may have a form suitable for arrangement of the modules within the regular polyhedral grid. Fluid may then flow through at least a subset of the arrangement of modules via the microfluidic channel of each module of the subset of the arrangement of modules. Some modules may include sensors, actuators, or inner microfluidic channel surface coatings. The arrangement of modules may form a microfluidic circuit that can perform a microfluidic circuit function. | 12-10-2015 |
| 20150350537 | VIRTUAL HEAD MOUNTED VIDEO CAMERA SYSTEM - A facial image capture system may capture images of a face of a person while the person is moving. A video camera may capture sequential images of a scene to which the video camera is directed. A marker-based location detection system may determine and generate information about the location of a marker worn on or close to the face of the person. A camera control system may automatically adjusts both the horizontal and vertical direction to which the video camera is directed so as to cause the sequential images of the camera to each be of the face of the person while the person is moving, based on the information about the location of the marker from the marker-based location detection system. | 12-03-2015 |
| 20150349910 | Systems and Techniques for Orbital Angular Momentum Based Reconfigurable Switching - In at least one aspect, a device for Orbital Angular Momentum (OAM) based optical communication includes a first spatial light modulator configured to down-convert a first plurality of higher-order OAM modes from a communication signal to a second plurality of higher-order OAM modes and a first Gaussian mode, a second spatial light modulator configured to drop the first Gaussian mode and add a second Gaussian mode to the second plurality of higher-order OAM modes, and a third spatial light modulator configured to up-convert the second plurality of higher-order OAM modes and the second Gaussian mode to a third plurality of higher-order OAM modes for further communications. | 12-03-2015 |
| 20150328453 | INTRATHORACIC PACEMAKER - The present invention provides a fully intrathoracic artificial pacemaker. The pacemaker is of sufficiently compact size to allow for implantation of both the electrode and the power source within the chest cavity. In exemplary embodiments, a screw-type electrode is used for connection to heart tissue, and a relatively short lead is used to connect the electrode to a battery unit, which can comprise electronics for control of the pacemaker. An assembly for implanting the pacemaker, as well as methods of implanting the pacemaker, are disclosed. In embodiments, the device is designed as a fetal pacemaker. | 11-19-2015 |
| 20150326210 | TIMING VIOLATION RESILIENT ASYNCHRONOUS TEMPLATE - An asynchronous circuit may include a single-rail logic datapath; one or more error-detecting latches; a controller that controls the error-detecting latches; and delay lines. The controller and the delay lines may cooperate to communicate with one or more other controllers that the output of the controlled error-detecting latches may be valid prior to when the error-detecting latches indicate whether or not an error occurred. | 11-12-2015 |
| 20150313967 | Methods and Agents for Wound Healing - This invention provides compositions and methods for topically treating skin wounds. The composition comprises C7, C7M, a variant thereof, or a combination thereof in a pharmaceutically acceptable carrier. The method comprises the steps of topically applying compositions of this invention to the skin wound. | 11-05-2015 |
| 20150300036 | AUTOMATED CONSTRUCTION OF TOWERS AND COLUMNS - A robot may extrude a tower or column. The robot may include an extrusion nozzle, a positioning system, a climbing apparatus, and a controller. The extrusion nozzle may controllably extrude uncured construction material. The positioning system may controllably cause the extrusion nozzle to traverse a perimeter layer of the tower or column. A climbing apparatus may controllably cause the robot to climb. A controller may autonomously: direct the positioning system to cause the nozzle to traverse the perimeter layer of the tower or column; direct the nozzle to extrude uncured construction material during the traverse; direct the climbing apparatus to cause the robot to climb an incremental amount; and repeat each of the foregoing positioning, extrusion, and climbing steps until the extruded tower or column attains a desired height. | 10-22-2015 |
| 20150297760 | 18F LABELED BODIPY DYE AND ITS DERIVATIVES FOR PET IMAGING OF HEART PERFUSION AND OTHERS - This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include | 10-22-2015 |
| 20150290466 | 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS - A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil. | 10-15-2015 |
| 20150287199 | IMAGE ENHANCEMENT USING MODULATION STRENGTH MAP AND MODULATION KERNEL - An image enhancement system may generate a net signed fractional modulation value at each location in an image using a modulation strength map (MSM) in combination with a modulation kernel F(θ). The system may scale an image value at each location using the net signed fractional modulation value at each location. Application of the algorithm may not result in systematic clipping of peri-edge locations to maximum or minimum brightness values, or any other form of systematic homogenization of values at peri-edge locations. | 10-08-2015 |
| 20150286872 | VISUAL TRACKING IN VIDEO IMAGES IN UNCONSTRAINED ENVIRONMENTS BY EXPLOITING ON-THE-FLY CONTXT USING SUPPORTERS AND DISTRACTERS - The present disclosure describes systems and techniques relating to identifying and tracking objects in images, such as visual tracking in video images in unconstrained environments. According to an aspect, a system includes one or more processors, and computer-readable media configured and arranged to cause the one or more processors to: identify an object in a first image of a sequence of images, identifying one or more regions similar to the object in the first image of the sequence of images, identifying one or more features around the object in the first image of the sequence of images, preventing drift in detection of the object in a second image of the sequence of images based on the one or more regions similar to the object, and verifying the object in the second image of the sequence of images based on the one or more features. | 10-08-2015 |
| 20150286713 | SYSTEM AND METHOD FOR FUZZY ONTOLOGY MATCHING AND SEARCH ACROSS ONTOLOGIES - A computer implemented method of matching ontologies is disclosed. The method includes, for each pair of entities of a first ontology and a second ontology, wherein each pair of entities includes a first entity from a first plurality of entities of the first ontology and a second entity from a second plurality of entities of the second ontology, and wherein the first entity and the second entity of each pair of entities is of a same data type: (1) determining a vector of similarities for the pair of entities; (2) determining a confidence score for the vector of similarities; (3) determining a relation score for each relation type based on the vector of similarities to measure relatedness between the first entity of the pair of entities and the second entity of the pair of entities; and (4) generating a mapping ontology based on the relation type, the relation score, and the confidence score of each pair of entities. | 10-08-2015 |
| 20150280149 | FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS - A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process. By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,β fashion is achieved resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins. | 10-01-2015 |
| 20150273341 | OPTIMAL PATROL STRATEGY FOR PROTECTING MOVING TARGETS WITH MULTIPLE MOBILE RESOURCES - The following information may be read from a memory system: an identification of each of multiple moving targets that are each expected to move in accordance with a schedule of when and where the target will move; the schedule; an identification of each of multiple mobile defense resources that each have a maximum movement speed and a maximum protection radius; and the maximum movement speed and the maximum protection radius of each mobile defense resource. A computer system may determine where each mobile defense resource should be at each of a sequential set of different times so as to optimize the ability of the mobile defense resources to protect each of the mobile targets from a single attack by an attacker against one of the targets at an unknown time based on the information read from the memory system. The determining may take into consideration that the attacker may observe and analyze movements of the mobile defense resources prior to the attack in formulating the attack. | 10-01-2015 |
| 20150273197 | IMPLANTABLE OXYGENATOR WITH SELF-CONTAINED ELECTROLYTE - An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system. | 10-01-2015 |
| 20150254499 | MULTI-VIEW 3D OBJECT RECOGNITION FROM A POINT CLOUD AND CHANGE DETECTION - A method of detecting objects in three-dimensional (3D) point clouds and detecting differences between 3D point clouds and the objects therein is disclosed. A method includes receiving a first scene 3D point cloud and a second scene 3D point cloud, wherein the first scene 3D point cloud and the second scene 3D point cloud include first and second target objects, respectively; aligning the first scene 3D point cloud and the second scene 3D point cloud; detecting the first and second target objects from the first scene 3D point cloud and the second scene 3D point cloud, respectively; comparing the detected first target object with the detected second target object; and identifying, based on the comparison, one or more differences between the detected first target object and the detected second target object. Further aspects relate to detecting changes of target objects within scenes of multiple 3D point clouds. | 09-10-2015 |
| 20150253470 | REFLECTIVE COLOR DISPLAY BASED ON TUNABLE SUB-WAVELENGTH HIGH CONTRAST GRATINGS - A sub-pixel unit for a reflective display includes a color filter including a tunable high contrast grating. The tunable high contrast grating reflects light within a first range of wavelengths, and the sub-pixel unit can exist in a first state and a second state, the first state reflecting at least one of (i) light within a different range of wavelengths, and (ii) light of a different intensity level, than the second state. | 09-10-2015 |
| 20150248450 | THROWAWAY SPATIAL INDEX STRUCTURE FOR DYNAMIC POINT DATA - The present disclosure relates to a short-lived throwaway index structure for generating an index from scratch in a short period of time rather than updating an index with every location change of moving objects. Rapid index construction results from the generation of Voronoi diagrams in parallel using multiple cloud servers simultaneously. | 09-03-2015 |
| 20150246933 | Compositions and Methods for Inhibiting Activity of Hypoxia-Inducible Transcription Factor Complex and Its Use for Treatment of Tumors - Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. | 09-03-2015 |
| 20150238431 | ICAM-1 TARGETING ELPS - Provided herein are therapeutic agents comprising an elastin-like peptide (ELP) component and a ligand that specifically targets and binds an ICAM-1 receptor. In one aspect, the ELP comprises, or alternatively consists essentially of, or yet further consists of one or more sequence(s) designated S48I48 and/or mICMA-1 SI and/or hICAM-1 S1 or biological equivalents thereof. In a further aspect, the ELP/ligand composition further comprises a therapeutic agent. In one aspect, the therapeutic agent is specific to the treatment or amelioration of symptoms associated with autoimmune disorders such as SjS. | 08-27-2015 |
| 20150236842 | HYBRID-BASED CANCELLATION IN PRESENCE OF ANTENNA MISMATCH - A multi-port hybrid-based cancellation network may include a first and second hybrid coupler, and a first and second two-port network. The second hybrid coupler may be distinct from the first hybrid coupler. The first two-port network may include a first filter connected between the first and the second hybrid couplers. The second two-port network may include a second filter that is distinct from but essentially the same as the first filter connected between the first and the second hybrid couplers. Other circuitry components may be connected to one of the ports of multi-port hybrid-based cancellation network. These other circuitry components may have a configuration that increases or maximizes signal isolation between at least two of the ports of the multi-port hybrid-based cancellation network. | 08-20-2015 |
| 20150236395 | REFLECTION AND HYBRID REFLECTION FILTERS - A two-port tunable or reconfigurable network having a filter transfer function may include: a network input port; a network output port; a hybrid coupler having a hybrid input port, a hybrid isolated port, a hybrid through port, and a hybrid coupled port; a first internal two-port network connected between the network input port and the hybrid input port; a second internal two-port network connected between the network output port and the hybrid isolated port; and a third internal two-port network connected between the hybrid through port and the hybrid coupled port. At least one of the first internal two-port network, the second internal two-port network, the third internal two-port network, and the hybrid coupler may be tunable or reconfigurable in response to an electrical signal or a user-operated control in a way that tunes or reconfigures the filter transfer function of the two-port tunable or reconfigurable network. | 08-20-2015 |
| 20150236390 | MINIATURE ACOUSTIC RESONATOR-BASED FILTERS AND DUPLEXERS WITH CANCELLATION METHODOLOGY - A cancellation-based filter may have at least one frequency pass band and at least one frequency stop band. The cancellation-based filter may include a first group of one or more band pass filters, each having at least one acoustic resonator, the first group providing at least one frequency pass band for the cancellation-based filter; at least one hybrid coupler; and a second group of one or more band pass filters, each having at least one acoustic resonator, the second group coupled to at least one of the at least one hybrid couplers, wherein the at least one hybrid coupler and the second group of one or more band pass filters interact to provide at least one frequency stop band for the cancellation-based filter. | 08-20-2015 |
| 20150236287 | EXCITONIC ENERGY TRANSFER TO INCREASE INORGANIC SOLAR CELL EFFICIENCY - The present disclosure relates to a photosensitive optoelectronic device comprising two electrodes, an inorganic subcell positioned between the two electrodes, wherein the inorganic subcell comprises at least one inorganic semiconductor material having a band gap energy (E | 08-20-2015 |
| 20150236279 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES - A compound having a structure of Formula M(L | 08-20-2015 |
| 20150232539 | Methods and Compositions for Detecting, Imaging, and Treating Small Cell Lung Cancer Utilizing Post-Translationally Modified Residues and Higher Molecular Weight Antigenic Complexes in Proteins - The present invention discloses ectopically expressed isoaspartylated proteins and antigenic peptide fragments thereof as potential biomarkers for cancer such as small cell lung cancer. Also disclosed are antigen recognition agents capable of specifically recognizing and binding to isoaspartylated proteins and/or antigenic peptide fragments thereof. Antigen recognition agents of the invention may be formed from proteins, antibodies, RNA aptamers, or other small molecules capable of specifically binding to an isoaspartylated protein or an antigenic peptide fragment thereof. Other aspects disclosed herein include imaging methods for using the isoaspartyl antigen recognition agents, therapeutic methods for treating small cell lung cancer and compositions for performing the same. | 08-20-2015 |
| 20150232468 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS - Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/ | 08-20-2015 |
| 20150209409 | USES OF IL-12 IN HEMATOPOIESIS - Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of Il-12 for bone marrow preservation or recovery. | 07-30-2015 |
| 20150209361 | MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer - A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant. | 07-30-2015 |
| 20150209335 | METHODS AND SMALL MOLECULE THERAPEUTICS COMPRISING FUSED ELPS - This disclosure provides a novel compositions and methods to deliver small molecule therapeutics using genetically engineered protein polymers connected to the ‘cognate’ human protein target of that drug. | 07-30-2015 |
| 20150204887 | HUMAN MYELOID DERIVED SUPPRESSOR CELL CANCER MARKERS - Provided herein are methods for determining the presence of cancer (malignant versus benign), monitoring the progression of cancer, monitoring cancer relapse, monitoring the response to cancer therapy, or cancer staging in a subject, by evaluating CD33 | 07-23-2015 |
| 20150163044 | Enhancing Isolation and Impedance Matching in Hybrid-Based Cancellation Networks and Duplexers - Multi-port hybrid-based cancellation networks may be used to enable simultaneous transmit and receive in one or more co-existent communication systems. A multi-port hybrid-based cancellation network may include a first and second quadrature hybrid, a first and second two-port network, and other circuitry components. The second quadrature hybrid may be distinct from the first quadrature hybrid. The first two-port network may include a first filter or a first amplifier connected between the first and the second quadrature hybrids. The second two-port network may include a second filter or a second amplifier that is distinct from but essentially the same as the first filter or the first amplifier connected between the first and the second quadrature hybrids. The other circuitry components may be connected between or connected to a connection between one of the quadrature hybrids and one of the two-port networks. These other circuitry components may have a configuration that minimizes signal return loss at least one of the ports of the multi-port hybrid-based cancellation network. They may in addition or instead have a configuration that maximizes signal isolation between at least two of the ports of the multi-port hybrid-based cancellation network. | 06-11-2015 |
| 20150161232 | NOISE-ENHANCED CLUSTERING AND COMPETITIVE LEARNING - Non-transitory, tangible, computer-readable storage media may contain a program of instructions that enhances the performance of a computing system running the program of instructions when segregating a set of data into subsets that each have at least one similar characteristic. The instructions may cause the computer system to perform operations comprising: receiving the set of data; applying an iterative clustering algorithm to the set of data that segregates the data into the subsets in iterative steps; during the iterative steps, injecting perturbations into the data that have an average magnitude that decreases during the iterative steps; and outputting information identifying the subsets. | 06-11-2015 |
| 20150150860 | Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications - Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof | 06-04-2015 |
| 20150138925 | ULTRASOUND BEAMFORMER WITH INDIVIDUAL ARRAY ELEMENT MULTIPLEXERS - An ultrasound beamformer may include an array of ultrasound transducer elements. Multiple signal transmitters may each generate an ultrasound signal that is different from the ultrasound signal generated by each of the others. The number of ultrasound transmitters may be no more than half the number of ultrasound transducer elements. Each multiplexer may have multiple signal inputs, each connected to a different one of the ultrasound signals; an output that drives the ultrasound transducer element; and a control input that controls which of the ultrasound signals at the signal inputs to the multiplexer is delivered to the output of the multiplexer based on a control signal. The controller may generate the control signals with a collective configuration that causes the array of ultrasound transducer elements to steer an/or focus a beam of ultrasound energy in one or more different ways at one or more different times. | 05-21-2015 |
| 20150132222 | METHODS AND COMPOSITIONS FOR POSITRON EMISSION TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING - This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with | 05-14-2015 |
| 20150123048 | DOPED ORGANIC CARRIER TRANSPORT MATERIALS - The present invention provides for organometallic and organic dopants suitable for use in organic carrier transporting materials. Also provided are organic light emitting devices containing doped organic carrier transporting materials. | 05-07-2015 |
| 20150104428 | Compositions and Treatment Methods for Mesenchymal Stem Cell-Induced Immunoregulation - Mesenchymal Stem Cells (MSCs), including bone marrow-derived MSCs (BMMSCs) expressing Fas and FasL, and secreting MCP-1 are disclosed. Also disclosed are methods for upregulating regulatory T cells in a subject by administering MSCs, including BMMSCs. Also disclosed are methods for treating systemic sclerosis or colitis in a subject by administering MSCs, including BMMSCs. | 04-16-2015 |
| 20150065436 | INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES - The present invention relates to peptidomimetics that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1α-p300/CBP interaction, are also disclosed. | 03-05-2015 |
| 20150038433 | Clusterin Pharmaceuticals and Treatment Methods Using the Same - Disclosed are pharmaceutical compositions comprising clusterin and polypeptides substantially the same as clusterin and treatment methods for inflammatory diseases and dry eye disease. The pharmaceutical compositions include an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The clusterin is preferably secreted clusterin. The method of treating dry eye disease includes administering to a patient in need an effective amount of a pharmaceutical composition comprising an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The method of treating a disease state characterized by inflammation includes administering to a patient having the disease state an amount of isolated clusterin or a protein substantially the same as clusterin effective to decrease the activity of a matrix metallproteinase selected from the group consisting of MMP-9, MMP-2 and MMP-7. | 02-05-2015 |
| 20150033371 | HAIR FOLLICLE STEM CELLS AND METHODS OF USE SAME - The disclosure provides isolated hair follicle stem cells (hfSC) having inactivated BMP signaling, which are discovered to express keratin 15. Also provided are hfSC that have constitutively activated BMP signaling and methods of using such hfSC for screening candidate agents suitable for inhibiting BMP signaling in hfSC and promoting hair growth. Further provided are methods of activating hfSC and promoting hair growth from hfSC. | 01-29-2015 |
| 20150031871 | RNA-Mediated Gene Modulation - An isolated RNA comprising an intron RNA that is released in a cell, thereby modulating the function of a target gene. Also disclosed are a composition comprising a chemokine and an isolated RNA of the invention or a DNA template for the isolated RNA, a composition comprising one or more agents that induce RNA-mediated modulation of the functions of two or more target genes in a cell, and methods of using these compositions for modulating the functions of genes in a cell. | 01-29-2015 |
| 20150018364 | CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS - The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation). | 01-15-2015 |
| 20150010777 | ELECTRODEPOSITION OF PLATINUM/IRIDIUM (PT/IR) ON PT MICROELECTRODES WITH IMPROVED CHARGE INJECTION PROPERTIES - Aspects of the present disclosure are directed to electrochemical approaches for synthesis of platinum-iridium alloys with selected platinum-iridium ratio content and subsequently predetermined mechanical properties and electrochemical impedance properties. Such can provide a simple and cost-effective process for preparing these electrodes, as compared to conventional thin film processing techniques. A three-electrode electrochemical electrodeposition system is described including an electrochemical cell with a working electrode on which the electrodeposited film is deposited, a counter electrode to complete the electrochemical circuit and a reference electrode to measure and control surface potential. Mixed layers of platinum atoms and iridium atoms can be deposited from electrolyte solution onto the working electrode surface to create an electrically conductive surface with material properties related to the composition of the as-deposited film. The mechanical properties and electrochemical properties of the film can be tuned by adjusting the electrodeposition parameters. | 01-08-2015 |
| 20140376419 | PASSIVE LEAKAGE CANCELLATION NETWORKS FOR DUPLEXERS AND COEXISTING WIRELESS COMMUNICATION SYSTEMS - A passive cancellation network may include a transmit input having a configuration that passively receives a transmit signal from a transmitter that is to be wirelessly transmitted; a transmit output having a configuration that passively delivers the transmit signal after processing by the passive cancellation network; a receive input having a configuration that passively receives a receive signal that includes undesirable leakage from the transmit signal; a receive output having a configuration that passively delivers the receive signal after processing by the passive cancellation network; and a passive feed forward cancellation circuit that passively cancels at least a portion of the undesired leakage from the transmit signal in the receive signal in a feed forward manner. | 12-25-2014 |
| 20140373603 | Reducing False Alarms with Multi-modal Sensing for Pipeline Blockage - A detection system and method of operation are disclosed. The system includes a first sensor coupled to a pipe associated with a pump and generates temperature data associated with a temperature of the pipe. The system includes a second sensor positioned within an acoustic sensing distance from the pump and that generates sound data associated with a sound of the pump. The system includes a processing device configured to execute data instructions to store a baseline temperature signature and a baseline acoustic signature, and receive the temperature data from the first sensor and the sound data from the second sensor. The processing device is configured to, based on (1) a determination that flow through the pipe is reduced by comparing temperature data to the baseline temperature signature, and (2) a determination that the pump remains operational based on comparing the acoustic data to the baseline acoustic signature, generate an indication that the pipe is blocked. | 12-25-2014 |
| 20140358930 | CLASSIFYING MESSAGE CONTENT BASED ON REBROADCAST DIVERSITY - A computer system running a program of instructions may classify content of a message. The message may be re-broadcasted in whole or in part by one or more re-broadcasters. An amount of time interval diversity may be determined in the time intervals between each successive pair of re-broadcasted messages. An amount of re-broadcaster diversity may be determined in the number of times the message has been re-broadcasted by each of the re-broadcasters. The content of the message may be classified based on the amount of time interval diversity and the amount of re-broadcaster diversity. | 12-04-2014 |
| 20140356721 | Coating Particles - A method includes combining a coating material and an uncoated particulate core material in a solution having a selected ionic strength. The selected ionic strength promotes coating of the uncoated particulate core material with the coating material to form coated particles; and the coated particles can be collected after formation. The coating material has a higher electrical conductivity than the core material. | 12-04-2014 |
| 20140356414 | Targeted Crosslinked Multilamellar Liposomes - A liposome composition that is useful for treating a subject in need of cancer treatment includes a cross-linked multilamellar liposome having an exterior surface and an interior surface. The interior surface defines a central liposomal cavity. The multilamellar liposome includes at least a first lipid bilayer and a second lipid bilayer. The first lipid bilayer is covalently bonded to the second lipid bilayer. At least one anticancer compound is disposed within the multilamellar liposome. Methods for treating subjects are also provided. | 12-04-2014 |
| 20140350266 | High-Performing Stable Green Replacements for Ammonium Perchlorate - A highly energetic, high-oxygen carrier suitable as high-performing green replacement for ammonium perchlorate includes halogen-free ionic salts consisting of fuel cations and over-oxidized anions containing multiple nitro- or nitromethyl-substituted azolyl ligands. The over-oxidized anions include a central atom selected from the group consisting of boron, aluminum, or gallium. Characteristically, the carrier has sufficient amounts of oxygen for complete or near complete combustion of the over-oxidized anions, the fuel cations, metal additives and binders. | 11-27-2014 |
| 20140343984 | SPATIAL CROWDSOURCING WITH TRUSTWORTHY QUERY ANSWERING - Spatial crowdsourcing systems and methods assign spatial tasks to be performed by human workers. The systems and methods can verify the validity of the results provided by workers. Every worker can have a reputation score stating the probability that the worker performs a task correctly. Every spatial task can have a confidence threshold determining the minimum quality of the accepted level of its result. To satisfy this threshold, a task may be assigned redundantly to multiple workers. A reputation score can be associated to every worker, which represents the probability that a worker performs a task correctly. A task may be assigned to a subset of workers whose aggregate reputation score satisfies the confidence of the task. | 11-20-2014 |
| 20140343101 | SMALL MOLECULE MODULATORS OF EPIGENETIC REGULATION AND THEIR THERAPEUTIC APPLICATIONS - Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof | 11-20-2014 |
| 20140340489 | Online coupled camera pose estimation and dense reconstruction from video - A product may receive each image in a stream of video image of a scene, and before processing the next image, generate information indicative of the position and orientation of an image capture device that captured the image at the time of capturing the image. The product may do so by identifying distinguishable image feature points in the image; determining a coordinate for each identified image feature point; and for each identified image feature point, attempting to identify one or more distinguishable model feature points in a three dimensional (3D) model of at least a portion of the scene that appears likely to correspond to the identified image feature point. Thereafter, the product may find each of the following that, in combination, produce a consistent projection transformation of the 3D model onto the image: a subset of the identified image feature points for which one or more corresponding model feature points were identified; and, for each image feature point that has multiple likely corresponding model feature points, one of the corresponding model feature points. | 11-20-2014 |
| 20140328863 | Induction of Differential Stress Resistance and Uses Thereof - This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. | 11-06-2014 |
| 20140327748 | RENDERING FOR AN INTERACTIVE 360 DEGREE LIGHT FIELD DISPLAY - An interactive, autostereoscopic system for displaying an object in 3D includes a mirror configured to spin around a vertical axis when actuated by a motor, a high speed video projector, and a processing system including a graphics card interfaced to the video projector. An anisotropic reflector is bonded onto an inclined surface of the mirror. The video projector projects video signals of the object from the projector onto the inclined surface of the mirror while the mirror is spinning, so that light rays representing the video signals are redirected toward a field of view of a 360 degree range. The processing system renders the redirected light rays so as to interactively generate a horizontal-parallax 3D display of the object. Vertical parallax can be included in the display by adjusting vertically the displayed views of the object, in response to tracking of viewer motion by a tracking system. | 11-06-2014 |
| 20140327691 | HIGH DYNAMIC RANGE IMAGE EDITING - A high dynamic range image editing system for editing an image file having pixels spanning a first range of light intensity levels in an image editing system that only displays differences in the light intensity levels of pixels within a second range of light intensity levels that is less than the first range of light intensity levels, without reducing the range of light intensity levels in the image file. | 11-06-2014 |
| 20140324359 | PREDICTING THE MOLECULAR COMPLEXITY OF SEQUENCING LIBRARIES - Predicting the molecular complexity of a genomic sequencing library is a critical but difficult problem in modern sequencing applications. Methods to determine how deeply to sequence to achieve complete coverage or to predict the benefits of additional sequencing are lacking. We introduce an empirical Bayesian method to accurately characterize the molecular complexity of a DNA sample for almost any sequencing application based on limited preliminary sequencing. | 10-30-2014 |
| 20140316275 | HIGH FREQUENCY ULTRASONIC CONVEX ARRAY TRANSDUCERS AND TISSUE IMAGING - A high frequency ultrasonic transducer may include a plurality of adjacent ultrasonic transducer elements. The adjacent transducer elements may be sized and configured so as to resonate at a frequency that is at least 15 MHz. The adjacent transducer elements may collectively form an aperture that is substantially convex along a lateral dimension spanning the cascaded width of the adjacent transducer elements. The aperture may be substantially concave along an elevation spanning the height of each of the transducer elements. The ultrasonic transducer and an associated transmitter system may be configured so as to enable ultrasound that is radiated from the plurality of the transducer elements to be focused on and to scan across locations that are no more than 30 millimeters from the aperture and that span across a field of view of at least 50 degrees without movement of the ultrasonic transducer or tissue during the scanning. | 10-23-2014 |
| 20140312421 | Vapor-Trapping Growth of Single-Crystalline Graphene Flowers - A method for growing a graphene layer on a metal foil includes placing a vessel into a chemical vapor deposition chamber, the vessel having a metal foil positioned therein. The method includes evacuating the chemical vapor deposition chamber, introducing hydrogen gas into the chamber to achieve a first pressure less than atmospheric pressure, heating the atmosphere in the chamber to anneal the metal foil, introducing methane and hydrogen into the chamber to achieve a second pressure less than atmospheric pressure. | 10-23-2014 |
| 20140308381 | CONTOUR CRAFTING EXTRUSION NOZZLES - An automated extrusion construction system may include an extrusion nozzle configured to extrude construction material in a substantially horizontal direction against an elongated and substantially vertical surface. An extrusion nozzle may have a height adjustment mechanism configured to adjust the height of an outlet in response to level deviations in the surface on which the construction material is extruded by the extrusion nozzle. An automated extrusion construction system may include a slicing mechanism configured to controllably slice through the extruded layer. | 10-16-2014 |
| 20140298049 | DIGITAL SIGNAL TRANSITION COUNTERS FOR DIGITAL INTEGRATED CIRCUITS - A digital integrated circuit may include a digital data processing circuit having multiple signal lines that each go through signal transitions during operation of the digital data processing circuit. A digital counter circuit may count the combined number of signal transitions that take place on at least two of the multiple signal lines during operation of the digital circuit. A digital counter circuit may count the number of times a particular pattern of signal transitions takes place on at least one signal line during operation of the circuit. A computer program may receive information indicative of a composition of a digital integrated circuit, input vectors to the digital integrated circuit, and how much power is being consumed by the digital integrated circuit under each of the input vectors. The program may output information indicative of an amount of power being consumed by each of multiple, different sub-sections of the digital integrated circuit while responding to the input vectors. | 10-02-2014 |
| 20140295549 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS BY STIMULATING ER STRESS - The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress. | 10-02-2014 |
| 20140288115 | COMPOSITIONS AND METHODS FOR TREATING BRAIN CANCER - It is discovered that noscapine is effective in treating temozolomide (TMZ)-resistant brain cancer. Provided are compositions and methods of treating brain cancer patients, in particular those that are TMZ-resistant. The patients are treated by administration of a therapeutically effective amount of noscapine or an analog thereof. In certain aspects, TMZ is also administered to the patients. Examples of brain cancers include glioma such as glioblastoma multiforme. | 09-25-2014 |
| 20140287426 | ANTIBODY AND ANTIBODY MIMETIC FOR VISUALIZATION AND ABLATION OF ENDOGENOUS PROTEINS - Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein. | 09-25-2014 |
| 20140279944 | SQL QUERY TO TRIGGER TRANSLATION FOR MAINTAINING CONSISTENCY OF CACHE AUGMENTED SQL SYSTEMS - An SQL query-to-procedure translation system may be used in connection with a relational database management system (RDBMS) that is augmented by a cache and a cache management system that manages the cache. The query-to-procedure translation system may include a data processing system that has at least one computer hardware processor and a configuration that, in response to a query issued by an application program for data from the relational database management system: intercepts the query; generates code that determines if data requested by the query that may be in the cache has changed; and registers the code as a procedure with the RDBMS. | 09-18-2014 |
| 20140279818 | GAME THEORY MODEL FOR PATROLLING AN AREA THAT ACCOUNTS FOR DYNAMIC UNCERTAINTY - Game theory models may be used for producing a strategy and schedule for patrolling an area like a rail transportation system. In some instances, the model may account for events that cause a patrol unit to deviate from a patrol schedule and route. For example, a patrol schedule may be generated for one or more patrol units using a Bayesian Stackelberg game theory model based on a map of the public transportation system, a schedule of the transports, a list of the one or more patrolling units, a probability distribution for the occurrence of the passenger not paying to ride the transports, a list of the one or more possible events that would delay the patrol units, and a probability distribution for the occurrence of the one or more possible events that would delay the patrolling units represented by a Markov-decision process. | 09-18-2014 |
| 20140277765 | HUMAN-BUILDING INTERACTION FRAMEWORK FOR PERSONALIZED COMFORT DRIVEN SYSTEM OPERATIONS IN BUILDINGS - A computer data processing system may provide control information for controlling how an environmental control system controls an environment within a building. The computer data processing system may receive and store reports from multiple users and/or may receive and store reports at different times from a user. Each report may provide information concerning how the user perceives the comfort level of the user's environment at the time the user supplies the information. The computer data processing system may determine and generate the control information for controlling how the environmental control system controls the environment based on the information concerning how each user perceives the comfort level of the user's environment at the time each user provides the information. In addition or instead, the computer data processing system may determine and generate such control information based on the information concerning how a user perceives the comfort level of the user's environment at the different times the user supplies the information. | 09-18-2014 |
| 20140274246 | LOCALIZED SHORTEST-PATHS ESTIMATION OF INFLUENCE PROPAGATION FOR MULTIPLE INFLUENCERS - A method and a system for resolving a two-player influencer blocking conflict are disclosed. The method and system may include to form a set of defender actions to increase a defender set of nodes; form a set of attacker actions; determine a defender strategy based the set of attacker actions, the defender strategy comprising a new defender action; to determine an attacker strategy that is based the set of defender actions; modify the set of defender actions to include the new defender action; update the set of attacker actions according to the attacker strategy; form a new set of attacker actions when the set of defender nodes increases more than a threshold; and form a display to show the defender set of nodes and the attacker set of nodes in a graph. | 09-18-2014 |
| 20140271961 | INSERTING INHIBITOR TO CREATE PART BOUNDARY ISOLATION DURING 3D PRINTING - A 3D printing system may print a desired 3D object. A fusible powder may fuse when subjected to a fusing condition. A deposition system may deposit portions of the fusible powder on a substrate. A fusing system may apply the fusing condition to the deposited fusible powder. Inhibitor material may not fuse when subjected to the fusing condition. An insertion system may insert a portion of the inhibitor material between portions of the deposited fusible powder after having been deposited by the deposition system, but before being fused by the fusing system, so as to form a boundary that defines at least a portion of a surface of the desired 3D object. | 09-18-2014 |
| 20140271419 | CATALYTIC REMOVAL OF GAS PHASE CONTAMINANTS - Systems and methods for removal of gas phase contaminants may utilize catalytic oxidation. For example, a method may include passing a gas that includes a gas phase contaminant through a catalytic membrane reactor at a temperature of about 150° C. to about 300° C., wherein the catalytic membrane reactor includes a bundle of tubular inorganic membranes, wherein each of the tubular inorganic membranes comprise a macroporous tubular substrate with an oxidative catalyst and a microporous layer disposed on a bore side of the macroporous tubular substrate, and wherein at least about 50% of the gas flows through the tubular inorganic membranes in a Knudsen flow regime; and oxidizing at least some of the gas phase contaminant with the oxidative catalyst layer, thereby reducing a concentration of the gas phase contaminant in the gas. | 09-18-2014 |
| 20140268356 | DYNAMIC FIELD OF VIEW THROTTLING AS A MEANS OF IMPROVING USER EXPERIENCE IN HEAD MOUNTED VIRTUAL ENVIRONMENTS - A head-mounted display (HMD) allows a user to view a virtual environment. The HMD displays a field of view to the user. However, the user may experience simulator sickness or motion sickness from viewing the field of view. The HMD is connected to a sensor which can monitor the user. By monitoring the user's physiological state, the user's simulator sickness can be detected or predicted. To reduce the negative effects, the field of view can be throttled. The field of view can also be throttled in order to provide a better user experience even if the user does not experience sickness. | 09-18-2014 |
| 20140268160 | SPECULAR OBJECT SCANNER FOR MEASURING REFLECTANCE PROPERTIES OF OBJECTS - An apparatus to measure surface orientation maps of an object may include a light source that is configured to illuminate the object with a controllable field of illumination. One or more cameras may be configured to capture at least one image of the object. A processor may be configured to process the image(s) to extract the reflectance properties of the object including an albedo, a reflection vector, a roughness, and/or anisotropy parameters of a specular reflectance lobe associated with the object. The controllable field of illumination may include limited-order Spherical Harmonics (SH) and Fourier Series (FS) illumination patterns with substantially similar polarization. The SH and FS illumination patterns are used with different light sources. | 09-18-2014 |
| 20140267637 | HYBRID STEREOSCOPIC VIEWING DEVICE - A virtual reality hardware and software platform comprised of a stereoscope which attaches to a mobile touchscreen computer/tablet. The stereoscope, in which the user looks through, covers just the top portion of the tablet screen. This top portion displays the stereoscopic view of a virtual environment. The bottom portion displays the two-dimensional view. The user touches the view with his/her thumbs and/or fingers in order to interact with and travel through the virtual environment seen in the view. | 09-18-2014 |
| 20140267460 | CONTROL OF AMBIENT AND STRAY LIGHTING IN A HEAD MOUNTED DISPLAY - A head mounted display (HMD) for viewing a virtual environment generally include a flat display (FD), lenses for focusing on the FD, and a housing to enclose the FD and lenses. The housing is generally opaque to block out all external light, so the viewer only sees light from the FD. By making a portion or all of the housing translucent or transparent, ambient light and other external light can be seen by the viewer, providing additional visual cues and a larger perceived field of view. Additionally, other people can see light from the FD. The lenses are configured to view the FD and parts of the translucent housing. | 09-18-2014 |
| 20140267313 | GENERATING INSTRUCTIONS FOR NONVERBAL MOVEMENTS OF A VIRTUAL CHARACTER - Programs for creating a set of behaviors for lip sync movements and nonverbal communication may include analyzing a character's speaking behavior through the use of acoustic, syntactic, semantic, pragmatic, and rhetorical analyses of the utterance. For example, a non-transitory, tangible, computer-readable storage medium may contain a program of instructions that cause a computer system running the program of instructions to: receive a text specifying words to be spoken by a virtual character; extract metaphoric elements, discourse elements, or both from the text; generate one or more mental state indicators based on the metaphoric elements, the discourse elements, or both; map each of the one or more mental state indicators to a behavior that the virtual character should display with nonverbal movements that convey the mental state indicators; and generate a set of instructions for the nonverbal movements based on the behaviors. | 09-18-2014 |
| 20140255806 | METHANE-BASED POWER GENERATION WITH ZERO-CARBON EMISSIONS - The present invention provides a method of converting a hydrocarbon into H | 09-11-2014 |
| 20140244552 | GLOBAL MODEL FOR FAILURE PREDICTION FOR ARTIFICIAL LIFT SYSTEMS - Methods and systems for predicting failures in an artificial lift system are disclosed. One method includes extracting one or more features from a dataset including time sampled performance of a plurality of artificial lift systems disposed across a plurality of different oil fields, the dataset including data from failed and normally operating artificial lift systems. The method also includes forming a learning model based on identified pre-failure signatures in the extracted features, the learning model configured to predict a failure of an artificial lift system based on observation of one of the identified pre-failure signatures in operational data received from the artificial lift system. | 08-28-2014 |
| 20140239249 | RAPID BIOLOGICAL SYNTHESIS PROCESS TO PRODUCE SEMICONDUCTING CHALCOGENIDE NANOSTRUCTURES FOR TRANSISTOR OR SOLAR CELL APPLICATIONS - The process disclosed herein produces macroscopic quantities of semiconducting arsenic sulfide nanofibers within one to three days. The process is biotically influenced by the bacteria | 08-28-2014 |
| 20140237487 | COMPLEX EVENT PROCESSING FOR DYNAMIC DATA - A complex event processing system and method of operation are disclosed. The system includes, in one example, a monitor configured to detect, from measurements received from one or more data streams, observations relating to the measurements, and interpretations of the observations, a plurality, an occurrence of an event, and a state transition engine configured to receive the event and, based at least in part on the event, determine a current state of a particular entity of a dynamic system based on a state model as well as a next state of the particular entity to which the state model should transition, wherein the particular entity of the dynamic system is associated with the event. The system also includes an action determination component configured to determine an action to be taken based on the current state and the next state, a role determination component configured to determine a role associated with the action to be taken, and a notification component configured to generate one or more notifications to entities associated with the role, the one or more notifications including the action to be taken. | 08-21-2014 |
| 20140234958 | GENE DELIVERY SYSTEM AND METHOD OF USE - A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence. | 08-21-2014 |
| 20140230790 | ELECTRODES FOR MULTI-POINT IGNITION USING SINGLE OR MULTIPLE TRANSIENT PLASMA DISCHARGES - A device for providing ignition of a fuel-air mixture using a transient plasma discharge is provided. The device includes an anode coupled to receive a voltage; and a cathode disposed in proximity to the anode and coupled to a ground, wherein at least one of the anode and the cathode includes a protrusion that enhances an electric field formed between the anode and the cathode, the protrusion forming a sharp edge defining a plurality of points, each point forming a path of shortest distance between the anode and the cathode. | 08-21-2014 |
| 20140230770 | TRANSIENT PLASMA ELECTRODE FOR RADICAL GENERATION - A transient plasma electrode apparatus may include an elongated electrode having a first and a second end. The first end may connect to a source of high voltage pulses. An insulation jacket may surround a portion of the electrode. An electric-field enhancing protrusion may be at the second end of the elongated electrode. The protrusion may cause an electric field when a high voltage is applied between the elongated electrode and a metallic wall of a combustion chamber in which the electrode is placed. The electric field may be greater at the second end as compared to along the length of the electrode. | 08-21-2014 |
| 20140211779 | SCALABLE SYNCHRONIZATION FOR DISTRIBUTED MULTIUSER MIMO - Each wireless access point in a network may transmit pilot bursts; receive pilot bursts; determine the timing, carrier frequency, and/or sampling frequency of each received pilot burst; determine an offset between the timing, carrier frequency, and/or sampling frequency of each received pilot burst and its own transmitted signals; and deliver one or more of these determined offsets to a computer server. The computer server may receive these offsets and, based on them, compute and deliver to each wireless access point a timing, carrier frequency, and/or sampling frequency correction factor. Each wireless access point may adjust its transmitted timing, carrier frequency, and/or sampling frequency in accordance with these correction factors. | 07-31-2014 |
| 20140210474 | LINEAR TRANSFORM FOR DIFFUSION MRI - Samples of a Fourier transform of a signal may be received that are distributed in a generally spherically-shaped pattern on a surface of at least one sphere. The samples may be assembled to form a profile function having a domain that is a surface of at least one sphere. Information indicative of at least one property of the signal may be determined by applying a spherical linear transform to the profile function. The spherical linear transform may use more than just an equator of the profile function for each of multiple orientations. | 07-31-2014 |
| 20140206763 | PHENYLBUTYRATE FOR TREATMENT OF SPORADIC INCLUSION-BODY MYOSITIS AND DISORDERS RELATING TO AUTOPHAGY IMPAIRMENT OR AMYLOID BETA 42 ACCUMULATION - Disclosed is a method of improving lysosomal activity in a patient in need thereof including administering to the patient an effective amount of phenylbutyrate, preferably 4-phenylbutyrate in the form of at least one of sodium phenylbutyrate or glycerol phenylbutyrate. Also disclosed a method of improving lysosomal activity or ameliorating a pathological phenotype in a cell having impaired autophagy comprising treating the cell with phenylbutyrate, preferably 4-phenylbutyrate in the form of at least one of NaBP or GPB. The phenylbutyrate is generally administered in the form of a pharmaceutical composition including the phenylbutyrate and at least one carrier. | 07-24-2014 |
| 20140206596 | Design of pH-Sensitive Oligopeptide Complexes For Drug Release Under Mildly Acidic Conditions - The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly pH-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of CPPs to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same. | 07-24-2014 |
| 20140202519 | BROADBAND SUB-WAVELENGTH DIFFRACTIVE OPTICS FOR SOLAR CELLS AND METHODS OF MAKING AND USING THE SAME - Provided are solar cell assemblies for harvesting solar radiation having a diffractive optic, a reflective surface that directs solar radiation to the diffractive optic, and a plurality of solar converters including a first converter having a first energy conversion efficiency, wherein the diffractive optic directs a first portion of the solar radiation to the first converter and a second portion of the solar radiation to the second converter. | 07-24-2014 |
| 20140199309 | FRAGMENT OF SECRETED HEAT SHOCK PROTEIN-90ALPHA (HSP90ALPHA) AS VACCINES OR EPITOPE FOR MONOCLONAL ANTIBODY DRUGS OR TARGET FOR SMALL MOLECULE DRUGS AGAINST A RANGE OF SOLID HUMAN TUMORS - The invention provides methods for treating HIF-1α-overexpressing human tumors, inhibiting HIF-1α-overexpressing tumor invasion and preventing tumor metastasis, and/or promoting tumor prophylaxis, using various types of inhibitors against the Hsp90α from the tumors. | 07-17-2014 |
| 20140192050 | THREE-DIMENSIONAL POINT PROCESSING AND MODEL GENERATION - A method for three-dimensional point processing and model generation includes applying a primitive extraction to the data in a point cloud to associate primitive shapes with points within the point cloud, the primitive extraction including, estimating normal vectors for the point cloud, projecting the estimated normal vectors onto a Gaussian sphere, detecting and eliminating point-clusters corresponding to planar areas of the point cloud to obtain a residual Gaussian sphere, detecting great-circle patterns on the residual Gaussian sphere to produce a segmented point cloud, projecting each segment of the segmented point cloud onto respective planes to produce respective two-dimensional point clouds, detecting circle patterns in each two-dimensional point cloud, and processing the circle patterns to determine cylinder parameters for each of a plurality of candidate cylinders, and assembling the candidate cylinders into a three-dimensional surface model of the scene. | 07-10-2014 |
| 20140188009 | CUSTOMIZABLE ACTIVITY TRAINING AND REHABILITATION SYSTEM - A system may include a calibration module that measures a range of limb and trunk movements made by a human subject during a calibration phase of the system. A customization module may customize pre-determined performance criteria based on the measured range of limb and trunk movements. An activity task presentation module may present an activity task to the human subject for performance during an activity phase. An activity assessment module may assess the human subject's performance of that activity task during the activity phase based on the pre-determined performance criteria. | 07-03-2014 |
| 20140186273 | Chitosan -Amelogenin Hydrogel for In Situ Enamel Growth - A composition for re-constructing enamel-coated substrates such as a tooth which includes an amelogenin, chitosan, and water. The composition may also include compounds providing calcium and phosphate ions. Methods using the composition are also provided. | 07-03-2014 |
| 20140154728 | COMPOSITIONS, SYSTEMS AND METHODS BASED ON THE DIFFERENTIATION OF EPICARDIAL CELLS TO TYPICAL AND ATYPICAL FATES - Disclosed are epicardium-derived mesenchymal cells (EPDCs) that differentiate to fates that are commonly adopted by mesenchymal cells elsewhere in the body, but not currently associated with the epicardium. Also disclosed are methods, systems and assays relating to adipocyte and/or osteogenic differentiation in EPDCs that are often related to disease or disregulated states, i.e. the “atypical” fates of epicardium-derived cells. Disclosed are specific EPDC cells that model both the typical fates and atypical fates of EPDCs, and resultant uses of such EPDC cells in systems, methods, compositions and drug discovery. | 06-05-2014 |
| 20140121236 | Compositions and Methods for Treating Myotonic Dystrophy Type 1 - Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: | 05-01-2014 |
| 20140120491 | ORTHODONTIC APPLIANCE WITH SNAP FITTED, NON-SLIDING ARCHWIRE - An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket. | 05-01-2014 |
| 20140114556 | TRAFFIC PREDICTION USING REAL-WORLD TRANSPORTATION DATA - Real-time high-fidelity spatiotemporal data on transportation networks can be used to learn about traffic behavior at different times and locations, potentially resulting in major savings in time and fuel. Real-world data collected from transportation networks can be used to incorporate the data's intrinsic behavior into a time-series mining technique to enhance its accuracy for traffic prediction. For example, the spatiotemporal behaviors of rush hours and events can be used to perform a more accurate prediction of both short-term and long-term average speed on road-segments, even in the presence of infrequent events (e.g., accidents). Taking historical rush-hour behavior into account can improve the accuracy of traditional predictors by up to 67% and 78% in short-term and long-term predictions, respectively. Moreover, the impact of an accident can be incorporated to improve the prediction accuracy by up to 91%. | 04-24-2014 |
| 20140113385 | Compositions and Methods for Identifying Single Antigens or Other Molecules in Cell Preparations - Disclosed are compositions and methods for identifying and preferably quantifying single antigens/molecules in tissue sections and other cell preparations. The methods make use of specific antibodies or aptomers linked with beads or other micro-particles using bright field microscopy having the purpose to identify and quantify single antigens or other molecules. | 04-24-2014 |
| 20140112909 | METHODS AND FORMULATIONS PROMOTING TISSUE/ORGAN REGENERATION, LONGEVITY AND HEALTHSPAN - A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day. | 04-24-2014 |
| 20140111136 | Pervasive Power Generation System - A power generation system includes a plurality of energy conversion devices for generating a plurality of power signals based on one or more sensed environmental conditions. The system further includes a plurality of power conditioning circuits each coupled to one or more of the energy conversion devices for receiving the power signals and storing energy in an energy storage system. The system also includes a selection circuit coupled to at least one of the power conditioning circuits and receiving a first input power signal from one of the power conditioning circuits and a second input power signal. The selection circuit is configured to deliver an output power signal representing a selection from between the first and second input power signals based on a relative voltage level of the first and second input power signals. A method of power generation, and associated power module, are also disclosed. | 04-24-2014 |
| 20140107823 | 3D PRINTING SHRINKAGE COMPENSATION USING RADIAL AND ANGULAR LAYER PERIMETER POINT INFORMATION - Errors caused by shrinkage during 3D printing may be minimized. A shape that most closely corresponds to the shape of a layer to be printed may be selected from a library of shapes. Each shape in the library may have shrinkage information associated with it that includes, for each of multiple points that define a perimeter of the library shape, a radial distance to the point from an origin of a coordinate system, an angle the radial distance makes with respect to an axis of the coordinate system, and information indicative of an anticipated amount by which the point will deviate from its specified location when the shape is printed due to shrinkage. Compensation for anticipated shrinkage may be calculated based on the shrinkage information that is associated with the selected shape from the library. The information indicative of the shape of the layer to be printed may be modified to minimize errors cause by shrinkage based on the calculated compensation. | 04-17-2014 |
| 20140100391 | EFFICIENT, SELF SUFFICIENT PRODUCTION OF METHANOL FROM A METHANE SOURCE VIA OXIDATIVE BI-REFORMING - A method for producing methanol from a methane source such as methane from natural (shale) gas by first reacting one equivalent of methane with oxygen from the air to result in complete combustion to produce carbon dioxide and water in a molar ratio of 1:2; then conducting a bi-reforming process with a mixture of methane: carbon dioxide:water having a ratio of 3:1:2 to produce metgas, a mixture of hydrogen and carbon monoxide having a molar ratio of 2:1 to 2.1:1; and finally converting metgas exclusively to methanol. The thus produced methanol can be dehydrated to form dimethyl ether, with water produced being recycled back to the bi-reforming process, if necessary. | 04-10-2014 |
| 20140099305 | COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY - Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells. | 04-10-2014 |
| 20140087411 | SYSTEM AND METHOD FOR DETERMINING TUMOR INVASIVENESS - A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell. | 03-27-2014 |
| 20140076403 | DIPYRIN BASED MATERIALS FOR PHOTOVOLTAICS, COMPOUNDS CAPABLE OF UNDERGOING SYMMETRY BREAKING INTRAMOLECULAR CHARGE TRANSFER IN A POLARIZING MEDIUM AND ORGANIC PHOTOVOLTAIC DEVICES COMPRISING THE SAME - The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of making organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. The present disclosure also generally relates to chromophoric compounds that combine strong absorption of light at visible wavelengths with the ability to undergo symmetry-breaking intramolecular charge transfer (ICT), and their use for the generation of free carriers in organic photovoltaic cells (OPVs) and electric-field-stabilized geminate polaron pairs. The present disclosure also relates to the synthesis of such compounds, methods of manufacture, and applications in photovoltaic systems and organic lasers. | 03-20-2014 |
| 20140073585 | PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE - Two vIRF4 (Kaposi's-sarcoma-associated-herpesvirus vIRF4) peptides, vif1, corresponding to aa202-216 of vIRF4, and vif2, corresponding to aa220-236 of vIRF4, are potent and selective HAUSP antagonists. The vif1 and vif2 peptides robustly suppress HAUSP DUB enzymatic activity, ultimately leading to p53-mediated anti-cancer activity. The vif1 and vif2 peptides, along with their homologues, are useful in treating ALL. | 03-13-2014 |
| 20140066640 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE - A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur. | 03-06-2014 |
| 20140058506 | 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS - A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil. | 02-27-2014 |
| 20140051709 | Compositions and Methods for Treating Myotonic Dystrophy Type 1 - Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: | 02-20-2014 |
| 20140050386 | SYSTEMS AND METHODS FOR IN VITRO AND IN VIVO IMAGING OF CELLS ON A SUBSTRATE - Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy. | 02-20-2014 |
| 20140046593 | Efficient K-Nearest Neighbor Search in Time-Dependent Spatial Networks - The class of k Nearest Neighbor (k NN) queries in spatial networks has been studied in the literature. Existing approaches for k NN search in spatial networks assume that the weight of each edge in the spatial network is constant. However, real-world edge-weights are time-dependent and vary significantly in short durations, hence invalidating the existing solutions. The problem of k NN search in time-dependent spatial networks, where the weight of each edge is a function of time, is addressed herein. Two indexing schemes (Tight Network Index and Loose Network Index) are proposed to minimize the number of candidate nearest neighbor objects and reduce the invocation of the expensive fastest-path computation in time-dependent spatial networks. We demonstrate the efficiency of our proposed solution via experimental evaluations with real-world data-sets, including a variety of large spatial networks with real traffic-data. | 02-13-2014 |
| 20140045264 | METHOD OF CRYOPRESERVATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS ON POLYMERIC SUBSTRATE - Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease. | 02-13-2014 |
| 20140038271 | METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS - The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications. | 02-06-2014 |
| 20140031295 | Recombinant C7 and Methods of Use - The present disclosure provides methods of treating epidermolysis bullosa, and/or preventing, preventing the progression of, or delaying the onset of one or more symptom associated with scarring, e.g., of blisters, in subjects with epidermolysis bullosa through chronic systemic administration of collagen 7. | 01-30-2014 |
| 20140031286 | Angiotensin (1-7) Dosage Forms and Uses Thereof - The present invention provides angiotensin (1-7) pharmaceutical compositions, dosage forms, and methods for their use, and methods for treating or limiting development of acquired immune deficiency syndrome. | 01-30-2014 |
| 20140030165 | MICROFLUIDIC DEVICES HAVING SOLVENT-RESISTANT COATING AND METHOD OF MANUFACTURE THEREOF - A method of coating a substrate, such as a microfluidic device having an interior surface, includes heating a gas including a perfluoroacrylate, a crosslinker and an initiator at a first temperature, maintaining the substrate at a second temperature lower than the first temperature in a reaction chamber, exposing the heated gas to the substrate in the reaction chamber, and reacting the perfluoroacrylate with the initiator and crosslinker to form a polymer coating on the surface of the substrate. | 01-30-2014 |
| 20140025356 | ITERATIVE ESTIMATION OF SYSTEM PARAMETERS USING NOISE-LIKE PERTURBATIONS - An estimating computer system may iteratively estimate an unknown parameter of a model or state of a system. An input module may receive numerical data about the system. A noise module may generate random, chaotic, or other type of numerical perturbations of the received numerical data and/or may generate pseudo-random noise. An estimation module may iteratively estimate the unknown parameter of the model or state of the system based on the received numerical data. The estimation module may use the numerical perturbations and/or the pseudo-random noise and the input numerical data during at least one of the iterative estimates of the unknown parameter. A signaling module may signal when successive parameter estimates or information derived from successive parameter estimates differ by less than a predetermined signaling threshold or when the number of estimation iterations reaches a predetermined number. | 01-23-2014 |
| 20140012938 | PREVENTING RACE CONDITION FROM CAUSING STALE DATA ITEMS IN CACHE - A data cache server may process requests from a data cache client to put, get, and delete data items into or from the data cache server. Each data item may be based on data in a data store. In response to each request to put a data item into the data cache server, the data cache server may determine whether any of the data in the data store on which the data item is based has or may have changed; put the data item into the data cache memory if none of the data in the data store on which the data item is based has been determined to have or maybe to have changed, and not put the data item into the data cache memory if data in the data store on which the data item is based has been determined to have or maybe to have changed. | 01-09-2014 |
| 20140004374 | Multi-Layer Encapsulated Structures | 01-02-2014 |
| 20130346039 | Modeling Nonlinear Systems - Systems and techniques, including machine-readable instructions, for modeling of nonlinear systems. In one aspect, an apparatus includes a collection of two or more inputs configured and arranged to receive input signals, a collection of two or more outputs configured and arranged to output output signals, a processing unit configured to transform the input signals into the output signals, wherein the transformation is non-linear and treats the non-linear system as a collection of multiple input, single output non-linear systems, and a data storage that stores characteristics of the transformation. | 12-26-2013 |
| 20130345115 | NUCLEAR PENETRATING H4 TAIL PEPTIDES FOR THE TREATMENT OF DISEASES MEDIATED BY IMPAIRED OR LOSS OF P53 FUNCTION - Methods for using chimeric polypeptides and other compositions comprising H4 tail peptides to increase p53 activity in cells and treat diseases mediated by lack of or dysfunctional p53 function as described. Also provided are chimeric polypeptides and other compositions comprising H4 tail peptides. | 12-26-2013 |
| 20130332240 | SYSTEM FOR INTEGRATING EVENT-DRIVEN INFORMATION IN THE OIL AND GAS FIELDS - A complex event processing system includes a complex event processing engine configured to detect one or more events across a plurality of data sources and provide a corrective action. The complex event processing system further includes an ontology repository in communication with the complex event processing engine, the ontology repository being configured to receive a first semantic query from the complex event processing engine. The complex event processing system also includes an enterprise integration pattern library in communication with the complex event processing engine, the enterprise integration pattern library being configured to receive a second semantic query from the complex event processing engine. | 12-12-2013 |
| 20130332120 | SYSTEM AND METHOD FOR AGGREGATING RESERVOIR CONNECTIVITIES - Described herein is a method of predicting production rates of one or more wells configured to extract petroleum from a petroleum reservoir, the production rates affected by one or more injectors configured to inject water into the petroleum reservoir, the method comprising: calculating a relationship parameter, using a plurality of models, for each of the one or more wells and an associated one of the one or more injectors; predicting future values of the relationship parameter calculated using the plurality of model; calculating a weighted aggregate of the future values of the relationship parameter, wherein weights for the future values are those that minimize a prediction error; predicting the production rates using the a weighted aggregate. | 12-12-2013 |
| 20130331616 | RECYCLING CARBON DIOXIDE VIA CAPTURE AND TEMPORARY STORAGE TO PRODUCE RENEWABLE FUELS AND DERIVED PRODUCTS - A method for recycling a carbon-containing greenhouse gas emissions such as carbon dioxide and methane (natural gas) or a hydrocarbon homolog thereof. The method includes the steps of capturing the emissions, sequestering them in an underground or undersea storage area, withdrawing them from the storage area after storage therein, and converting them to carbon-containing compounds such as methanol, dimethyl ether and derived products. Greenhouse gases such as carbon dioxide and methane are chemically recycled to provide a permanent and inexhaustible supply of carbon-containing fuels or products, which subsequently can be combusted or used without increasing the carbon dioxide content of the atmosphere. The method is thus effective in neutralizing or reducing the carbon footprint due to human activities related to combustion or use of carbon-containing fuels while providing a repeatedly sustainable carbon source. | 12-12-2013 |
| 20130330358 | CRYSTAL STRUCTURE AND PEPTIDE INHIBITORS OF HAUSP DEUBIQUITINASE - Two vIRF4 (Kaposi's-sarcoma-associated-herpesvirus vIRF4) peptides, vif1, corresponding to aa202-216 of vIRF4, and vif2, corresponding to aa220-236 of vIRF4, are potent and selective HAUSP antagonists. The vif1 and vif2 peptides robustly suppress HAUSP DUB enzymatic activity, ultimately leading to p53-mediated anti-cancer activity. The vif1 and vif2 peptides, along with their homologues, are useful in treating cancer through regulation of p53 activity in a cancer cell. Also disclosed is the crystalline structure of vIRF4-HAUSP TRAF domain complex. The structure is useful in computer aided drug design for identifying an agent that interacts with and inhibits HAUSP, resulting in p53 medicated cell cycle arrest of cancer cells. | 12-12-2013 |
| 20130330300 | High Telomerase Activity Bone Marrow Mesenchymal Stem Cells, Methods of Producing the Same and Pharmaceuticals and Treatment Methods Based Thereon - Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34 | 12-12-2013 |
| 20130322426 | TIMING SYNCHRONIZATION OF WIRELESS NETWORKS - A single wireless slave node may be in a timing virtual network (TVN) with neighboring wireless slave nodes. The single wireless slave node may store information indicative of the identity, link propagation delay, and channel signature of each of its neighboring wireless slave nodes. The single wireless slave node may repeatedly update a timing estimate based on the stored information and by performing a physical layer fast reference signal broadcast transmission and reception. | 12-05-2013 |
| 20130316958 | HIGHLY POTENT PEPTIDES TO CONTROL CANCER AND NEURODEGENERATIVE DISEASES - This invention provides compositions and method of diminishing or inhibiting autophagy by administering a FLIP protein that binds to Atg3, interfering with the formation of the LC3-Atg4-Atg7-Atg3 conjugation complex necessary for autophagy induction. This invention also provides FLIP peptide fragments that promote or induce autophagy by interfering with the activity of FLIP. | 11-28-2013 |
| 20130316948 | GROWTH HORMONE RECEPTOR DEFICIENCY CAUSES A MAJOR REDUCTION IN PRO-AGING SIGNALING, CANCER AND DIABETES IN HUMANS - A method for alleviating a symptom of chemotherapy in a subject comprises identifying a subject undergoing chemotherapy and then administering a therapeutically effective amount of a GH/IGF-1 Axis inhibitory composition to the subject. Typically, the levels of IGF-1 and/or GH in the subject are monitored as well as chemotherapy related symptoms. A method of alleviating oxidative damage, cellular damage including mutations, and insulin resistance in a subject is also provided. | 11-28-2013 |
| 20130315939 | Use of Cytokines and Mitogens to Inhibit Pathological Immune Responses - The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders. | 11-28-2013 |
| 20130315211 | AIRSYNC: ENABLING DISTRIBUTED MULTIUSER MIMO WITH FULL MULTIPLEXING GAIN - Systems and methods are described that provide not only time but also phase synchronization, thus enabling distributed multiuser multiple-input multiple-output (MIMO) architectures and techniques, such as supported by the IEEE 802.11n standard, where several access points are connected to a central server and operate as a large distributed multi-antenna access point. The systems and methods can lock the phase of all access points using a common reference (e.g., a synchronization tone) broadcasted over the air in conjunction with a predictive filter (e.g., a Kalman filter) which closely tracks the phase drift for each subcarrier channel. | 11-28-2013 |
| 20130313756 | PROCESS PLANNING OF MENISCUS SHAPES FOR FABRICATING SMOOTH SURFACES IN MASK IMAGE PROJECTION BASED ADDITIVE MANUFACTURING - A system may produce a desired three dimensional object that includes a tank that holds a liquid that solidifies upon exposure to light; a controllable stage that controllably moves within the tank; a controllable light source that emits a light image in a controllable pattern; and a controller that controls the controllable stage and the controllable light source so as to cause at least three cascaded layers to be sequentially solidified in the liquid that collectively approximate at least a section of the desired three dimensional object and that collectively form at least one up-facing step at their outer edges; and, following the solidification of the at least three cascaded layers, cause a meniscus of the liquid to form and solidify in the at least one up-facing step. The controller may control the number and/or width of the sequentially solidified cascaded layers. | 11-28-2013 |
| 20130312003 | METHOD AND SYSTEM FOR DYNAMICALLY PARALLELIZING APPLICATION PROGRAM - Provided is a method and system for dynamically parallelizing an application program. Specifically, provided is a method and system having multi-core control that may verify a number of available threads according to an application program and dynamically parallelize data based on the verified number of available threads. The method and system for dynamically parallelizing the application program may divide a data block to be processed according to the application program based on a relevant data characteristic and dynamically map the threads to division blocks, and thereby enhance a system performance. | 11-21-2013 |
| 20130301912 | IMAGE ENHANCEMENT USING MODULATION STRENGTH MAP AND MODULATION KERNEL - An image enhancement system may generate a net signed fractional modulation value at each location in an image using a modulation strength map (MSM) in combination with a modulation kernel F(θ). The system may scale an image value at each location using the net signed fractional modulation value at each location. Application of the algorithm may not result in systematic clipping of peri-edge locations to maximum or minimum brightness values, or any other form of systematic homogenization of values at peri-edge locations. | 11-14-2013 |
| 20130301910 | EXTRACTING OBJECT EDGES FROM IMAGES - A computer system may elicit from a human observer ground truth data useful in automatically detecting one or more features in images. The elicitation may include presenting an image to a human observer that has a visual indicator in an image, the visual indicator indicating having a location and orientation with respect to the image; asking the human observer to judge whether a particular image feature is present in the image at the location and orientation indicated by the visual indicator; receiving input from the human observer indicative of whether the particular image feature is present at the location and orientation indicated by the visual indicator; storing the input received from the human observer as part of the human-labeled ground truth data; and repeating the process described above one or more times in connection with a visual indicator that has a different location or orientation with respect to the image or that uses a different image. The stored human-labeled ground truth data may have a content that is useful in automatically detecting one or more features in other images. | 11-14-2013 |
| 20130296810 | APPARATUS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS - In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient. | 11-07-2013 |
| 20130295212 | DIGITAL MASK-IMAGE-PROJECTION-BASED ADDITIVE MANUFACTURING THAT APPLIES SHEARING FORCE TO DETACH EACH ADDED LAYER - A three-dimensional object may be produced in cascaded layers from a liquid resin that solidifies upon exposure to light. A translation stage may be positioned relative to a vat that is suitable for solidifying the highest un-solidified layer of the three-dimensional object directly beneath any existing, solidified layers of the three-dimensional object. A mask image projection system may project a two-dimensional image of the highest un-solidified layer through a transparent bottom of the vat and into the liquid resin. This may cause at least a portion of the liquid resin to solidify in the shape of the two-dimensional image and to adhere to the bottom of a surface beneath the solidified layer. A shearing force may be applied between the bottom surface of the solidified layer and the surface beneath that is great enough to detach the solidified layer from the surface beneath. | 11-07-2013 |
| 20130295058 | Pharmaceutical Compositions Comprising Gingiva A-Derived Mesenchymal Stem Cells and Methods of Treating Inflammation, Wound Healing and Contact Hypersensitivity - Disclosed are methods of polarizing macrophages to exhibit M2 phenotype, including introducing an effective amount of gingiva-derived mesenchymal stem cells to an environment comprising a population of macrophages such that the macrophages are in fluid communication with the gingiva-derived mesenchymal stem cells. Also disclosed are methods of promoting cutaneous wound healing including administering to a patient an effective amount of human gingiva-derived mesenchymal stem cells, thereby resulting in at least one of accelerated wound closure, rapid re-epithelialization, improved angiogenesis and improved tissue remodeling relative to untreated controls. Also disclosed are methods for attenuating contact hypersensitivity in a patient, the methods including administering to a patient an effective amount of human gingiva-derived mesenchymal stem cells at a time at least timeframe selected from the group consisting of before sensitization, after sensitization and before challenge and after challenge, thereby attenuating contact hypersensitity. | 11-07-2013 |
| 20130294777 | Reconfigurable Optical Transmitter - The present disclosure includes systems and techniques relating to reconfigurable optical transmitters. In some implementations, an apparatus, systems, or methods can include multiple ports to receive independent optical data signals or independent electrical signals that are converted into independent optical data signals, at least one optical pump laser, and one or more nonlinear optics elements configured and arranged to generate a phase conjugate for each of the independent optical data signals at least by combining the respective independent optical data signal with an output of the optical pump, and generate an output optical signal from the independent optical data signals at least by combining each of the independent optical data signals with its corresponding generated phase conjugate. | 11-07-2013 |
| 20130289497 | APPARATUS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS - In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient. | 10-31-2013 |
| 20130286012 | 3D BODY MODELING FROM ONE OR MORE DEPTH CAMERAS IN THE PRESENCE OF ARTICULATED MOTION - The present disclosure describes systems and techniques relating to generating three dimensional (3D) models from range sensor data. According to an aspect, multiple 3D point clouds, which are captured using one or more 3D cameras, are obtained. At least two of the 3D point clouds correspond to different positions of a body relative to at least a single one of the one or more 3D cameras. Two or more of the 3D point clouds are identified as corresponding to two or more predefined poses, and a segmented representation of the body is generated, in accordance with a 3D part-based volumetric model including cylindrical representations, based on the two 3D point clouds identified as corresponding to the two predefined pose. | 10-31-2013 |
| 20130278258 | METHOD FOR REDUCED FIELD OF VIEW MRI IN AN INHOMOGENEOUS FIELD WITH RAPID OUTER VOLUME SUPPRESSION - An MRI scanner may include one or more gradient waveform generators, gradient amplifiers, gradient coils, an RF waveform generator, an RF amplifier, an RF coil, a superconducting magnet, an RF detector; a digitizer, and a computer system that controls the one or more gradient waveform generators and the RF waveform generator so as to generate a magnetization saturation preparation pulse sequence that includes a tip-down pulse that is insensitive to RF field inhomogeneity followed by a tip-back pulse that employs a conjugate symmetry constraint in its energy spectrum. | 10-24-2013 |
| 20130275794 | RUNTIME SELECTION OF MOST ENERGY-EFFICIENT APPROACH FOR SERVICES REQUESTED BY MOBILE APPLICATIONS - An energy conservation module may be included in a mobile communication device that receives requests for services from application programs running in the device. For each request, the energy conservation module may determine which of different, selectable ways of performing the request is likely to be the most energy efficient. The energy conservation module may then cause the request to be performed in this most energy-efficient way. This determination may be dynamic and based on current operating conditions. Middleware between the application programs and an operating system may be included that presents various APIs to the application programs to allow them to easily invoke this functionality. The different, selectable ways of performing the services may be of any type, including different, selectable computer network interfaces (e.g., Wi-Fi and cellular) and whether a complex computation should be performed within or outside of the mobile communication device. | 10-17-2013 |
| 20130273649 | Culture medium for pluripotent stem cells - The present invention provides culture media and methods of culturing pluripotent stem cells, such as epiblast stem cells (EpiSCs) and embryonic stem cells (ESCs), in order to culture, derive, and reprogram pluripotent stem cells, such as converting ESCs to EpiSCs. | 10-17-2013 |
| 20130273514 | Optimal Strategies in Security Games - Different solution methodologies for addressing problems or issues when directing security domain patrolling strategies according to attacker-defender Stackelberg security games. One type of solution provides for computing optimal strategy against quantal response in security games, and includes two algorithms, the G | 10-17-2013 |
| 20130268822 | CORRECTABLE PARITY PROTECTED MEMORY - A correctable parity-protected memory system may include a parity-protected memory configured to hold dirty data, an error correction register configured to hold data, an exclusive-OR (XOR) circuit configured to exclusive-OR dirty data that is written into and removed from the parity-protected memory with the data in the error-correction register, and a controller. The controller may be configured to cause the results of the XOR circuit to accumulate in the error-correction register each time dirty data is written into and removed from the parity-protected memory, and, in response to detection of a fault in dirty data in the parity-protected memory, correct the fault based on the data in the error-correction register and dirty data in the parity-protected memory. | 10-10-2013 |
| 20130266512 | Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes - A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided. | 10-10-2013 |
| 20130260384 | METHOD FOR DETERMINING CANCER PROGNOSIS AND PREDICTION WITH CANCER STEM CELL ASSOCIATED GENES - Disclosed herein is a general method of formulating a cancer diagnosis or prognosis test based on a cancer stem cell (CSC)-associated gene expression signature, the method include steps of selecting a set of candidate CSC genes, identifying a subset of gene(s) as signature gene(s); and formulating a test based on measurement of the expression level of the signature genes. Also disclosed herein are exemplary diagnostic/prognostic tests formulated using the general method. In particular, provided herein is a set of signature genes for formulating a diagnostic/prognostic test of prostate cancer, including Axin2, CD44, Oct4, TACSTD2, NANOG, and CTNNB1. The present invention further provides kits, devices and systems for performing the diagnostic/prognostic test, which generally include analytical elements capable of detecting an analyte in a sample corresponding to the expression level of one or more signature genes, preferably selected from Axin2, CD44, Oct4, TACSTD2, NANOG, and CTNNB1. | 10-03-2013 |
| 20130252339 | MICRORNA-INDUCED ES-LIKE CELLS AND USES THEREOF - The invention relates to isolated nucleic acids comprising mir-302 genes. Also disclosed are expression vectors, host cells, and transgenic animals containing the nucleic acids, and use of the nucleic acids to generate ES-like cells. | 09-26-2013 |
| 20130252101 | NANOPOROUS SILICON AND LITHIUM ION BATTERY ANODES FORMED THEREFROM - An electrode for a lithium ion battery, the electrode including nanoporous silicon structures, each nanoporous silicon structure defining a multiplicity of pores, a binder, and a conductive substrate. The nanoporous silicon structures are mixed with the binder to form a composition, and the composition is adhered to the conductive substrate to form the electrode. The nanoporous silicon may be, for example, nanoporous silicon nanowires or nanoporous silicon formed by etching a silicon wafer, metallurgical grade silicon, silicon nanoparticles, or silicon prepared from silicon precursors in a plasma or chemical vapor deposition process. The nanoporous silicon structures may be coated or combined with a carbon-containing compound, such as reduced graphene oxide. The electrode has a high specific capacity (e.g., above 1000 mAh/g at current rate of 0.4 A/g, above 1000 mAh/g at a current rate of 2.0 A/g, or above 1400 mAh/g at a current rate of 1.0 A/g). | 09-26-2013 |
| 20130245952 | SYSTEM AND METHOD FOR CHARACTERIZING A FLOW PROPERTY OF A PRODUCTION WELL SITE IN A RESERVOIR - A method and system of characterizing a flow property of a production well site in a reservoir are provided. The method includes identifying a plurality of injection and production well sites in the reservoir; injecting fluid into selected injection well sites in accordance with an injection schedule; monitoring an output at the production well sites; determining a time delay between the selected injection sites and the production sites based on the monitored output using an estimated capacitance model; and characterizing a flow property of a production well site using the time delay and the estimated capacitance model. | 09-19-2013 |
| 20130243822 | Composition and Method for Healing of Skin Wounds - This invention provides compositions and methods for topically treating skin wounds. The composition comprises C7, C7M, a variant thereof, or a combination thereof in a pharmaceutically acceptable carrier. The method comprises the steps of topically applying compositions of this invention to the skin wound. | 09-19-2013 |
| 20130237686 | Methods and Compositions for the Rapid Synthesis of Radiometal-Labeled Probes - The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies. | 09-12-2013 |
