| University of South Carolina Patent applications |
| Patent application number | Title | Published |
|---|
| 20160108104 | APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE - Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis C virus infection. These ApoE polypeptides can inhibit the entry of hepatitis C virus into cells, and inhibit viral replication. Nucleic acids encoding these polypeptides are also disclosed, as well as methods | 04-21-2016 |
| 20160049559 | ORGANIC PHOSPHOR-FUNCTIONALIZED NANOPARTICLES AND COMPOSITIONS COMPRISING THE SAME - Provided is a phosphor-functionalized nanoparticle that includes an inorganic nanoparticle core; surface polymer brushes that include a plurality of long-chain polymers bonded to the surface of the inorganic nanoparticle core, said long-chain polymers each having molecular weight greater than 500, and a plurality of short-chain polymers bonded to the surface of the inorganic nanoparticle core, said short-chain polymers each having molecular weight less than 0.5 times the average molecular weight of the long-chain polymers; and one or more organic phosphors bonded to at least one of the inorganic nanoparticle core and one or more of the plurality of short-chain polymers. Graft density of the short-chain polymers on the surface of the inorganic nanoparticle core (σ | 02-18-2016 |
| 20150272953 | METHOD FOR TREATING PROSTATE CANCER - The invention provides a method for treating prostate cancer in a subject comprising administering to the subject an effective amount of a selective inhibitor of one or more of CDK8 and CDK19. In some embodiments the inhibitor inhibits CDK19. In some embodiments, the inhibitor inhibits CDK8 at a Kd of lower than 200 nM and/or inhibits CDK19 at a Kd of lower than 100 nM. In some embodiments, the prostate cancer is androgen independent. In some embodiments, the prostate cancer is androgen independent due to one or more of androgen receptor gene amplification, androgen receptor gene mutation, ligand-independent transactivation of androgen receptor and activation of intracellular androgen synthesis. In some embodiments, the inhibitor inhibits increased activity of NF-κB. In some embodiments, the inhibitor does not inhibit increased basal levels of NF-κB. In some embodiments, inhibition of one or more genes by AR is not inhibited. | 10-01-2015 |
| 20150174196 | COMPOSITIONS AND METHODS FOR WOUND HEALING AND TISSUE REPAIR - Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue. | 06-25-2015 |
| 20150054595 | THREE DIMENSIONAL BRANCHLINE COUPLER USING THROUGH SILICON VIAS AND DESIGN STRUCTURES - A three dimensional (3D) branchline coupler using through silicon vias (TSV), methods of manufacturing the same and design structures are disclosed. The method includes forming a first waveguide structure in a first dielectric material. The method further includes forming a second waveguide structure in a second dielectric material. The method further includes forming through silicon vias through a substrate formed between the first dielectric material and the second dielectric material, which connects the first waveguide structure to the second waveguide structure. | 02-26-2015 |
| 20150054592 | ON-CHIP VERTICAL THREE DIMENSIONAL MICROSTRIP LINE WITH CHARACTERISTIC IMPEDANCE TUNING TECHNIQUE AND DESIGN STRUCTURES - A vertical three dimensional (3D) microstrip line structure for improved tunable characteristic impedance, methods of manufacturing the same and design structures are provided. More specifically, a method is provided that includes forming a first microstrip line structure within a back end of the line (BEOL) stack. The method further includes forming a second microstrip line structure separated from the BEOL stack by a predetermined horizontal distance. | 02-26-2015 |
| 20140366225 | Endogenous Regulator of RNA Silencing in Plants - Compositions and methods are described which use RAV proteins and genes that encode such proteins to regulate RNA silencing in plant cells. Novel ntRAV proteins and genes are also described. | 12-11-2014 |
| 20140350692 | Biomineralization Promoting Materials and Methods of Forming Same - Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds. | 11-27-2014 |
| 20140349367 | Hydrolytically Degradable Micellar Hydrogels - Degradable and biologically inert hydrogel networks are described. The hydrogel networks are crosslinked and based on a biocompatible polymer that is chain extended with hydrophobic segments that include no more than 5 hydrophobic monomers to form a macromonomer that is then crosslinked to form a network that includes individual micelles throughout the crosslinked network. The hydrophobic segments of the macromonomer as well as other potentially toxic materials such as crosslink initiators can be sequestered in the micelles to better control degradation characteristics of the network as well as prevent toxicity to developing cellular structures of the network. | 11-27-2014 |
| 20140342463 | Nanoscale Spintronic Chemical Sensor - In general, the present disclosure is directed toward a novel hybrid spintronic device for converting chemical absorption into a change in magnetoresistance. This device uses a novel magnetic material which depends on the attachment of an organic structure to a metallic film for its magnetism. Changes in the chemical environment lead to absorption on the surface of this organometallic bilayer and thus modify its magnetic properties. The change in magnetic properties, in turn, leads to a change in the resistance of a magnetoresistive structure or a spin transistor structure, allowing a standard electrical detection of the chemical change in the sensor surface. | 11-20-2014 |
| 20140303242 | Sparstolonin B Based Pharmaceutical Agent to Treat Pathological Angiogensis - Anti-angiogenesis methods and compositions are described. The anti-angiogenic effect is provided by application of sparstolonin B or a derivative thereof to endothelial cells. The sparstolonin B or derivative thereof can inhibit angiogenesis by targeting endothelial cell cycle progression, cell migration, and chemotaxis. | 10-09-2014 |
| 20140296484 | Cyclin Based Inhibitors of CDK2 and CDK4 - Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation. | 10-02-2014 |
| 20140287345 | Mixed Ionic and Electronic Conductor Based on Sr2Fe2-xMoxO6 Perovskite - In accordance with the present disclosure, a method for fabricating a symmetrical solid oxide fuel cell is described. The method includes synthesizing a composition comprising perovskite and applying the composition on an electrolyte support to form both an anode and a cathode. | 09-25-2014 |
| 20140247447 | Systems and Methods for Spatial Heterodyne Raman Spectroscopy - The present subject matter is directed to a device for spectroscopy. The device includes an excitation source and a first spatial heterodyne interferometer configured to receive wavelengths from the excitation source and filter the wavelengths to produce fringes on a sample. The device also includes a second heterodyne interferometer configured to receive Raman wavelengths from the sample. | 09-04-2014 |
| 20140208950 | Methods and Sensors for the Detection of Active Carbon Filters Degradation with EMIS-ECIS PWAS - Active carbon filters and systems that are operative to detect active carbon filter degradations are provided. The active carbon filter can include a carbon filter comprising activated carbon and defining a filter surface; a first piezoelectric wafer active sensor on the filter surface that is electrically isolated from the carbon filter; and a second piezoelectric wafer active sensor on the filter surface that is electrically connected to the filter surface; and an impedance monitoring device electrically connected to the first piezoelectric wafer active sensor and the second piezoelectric wafer active sensor. Methods are also disclosed for determining if any degradation has occurred in an active carbon filter. | 07-31-2014 |
| 20140179595 | APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE - Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis C virus infection. These ApoE polypeptides can inhibit the entry of hepatitis C virus into cells, and inhibit viral replication. Nucleic acids encoding these polypeptides are also disclosed, as well as methods | 06-26-2014 |
| 20140034132 | Microfluidic Devices for the Generation of Nano-Vapor Bubbles and Their Methods of Manufacture and Use - Microfluidic devices having superhydrophilic bi-porous interfaces are provided, along with their methods of formation. The device can include a substrate defining a microchannel formed between a pair of side walls and a bottom surface and a plurality of nanowires extending from each of the side walls and the bottom surface. For example, the nanowires can be silicon nanowires (e.g., pure silicon, silicon oxide, silicon carbide, etc., or mixtures thereof). | 02-06-2014 |
| 20140031739 | Use of Fusarochromanone and Its Derivatives in the Diagnosis and Treatment of Cancer and Other Diseases - A method of photodynamic therapy to treat diseased cells in an animal is generally provided. According to the method, 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof is administered to the animal such that the 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof accumulates in the diseased cells. Then, the diseased cells containing 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof is exposed to light energy (e.g., ultraviolet light). | 01-30-2014 |
| 20140027005 | Enhanced Flow Boiling in Microchannels by High Frequency Microbubble-Excited and -Modulated Oscillations - Microfluidic devices, along with their methods of formation and use, are provided. The microfluidic device can include a substrate with a main channel and a first auxiliary channel defined in the substrate's surface. The main channel has a main width of about 1000 μm or less. The first auxiliary channel intersects with the main channel at a first aperture defined in a first side wall of the main channel. A second auxiliary channel can intersect with the main channel at a second aperture defined in a second side wall of the main channel. A plurality of main channels and respective auxiliary channel(s) can be included on the surface. | 01-30-2014 |
| 20130279075 | Energy Storage from Cellulose Fiber Materials - An asymmetric supercapacitor is described. The supercapacitor includes a first electrode, a second electrode, a thin film separator, and an electrolyte. The first electrode comprises functionalized cellulose fiber and the second electrode comprises functionalized cellulose fiber and metal oxide. | 10-24-2013 |
| 20130236431 | Compositions and Methods for Tissue Engineering, Tissue Regeneration and Wound Healing - In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel structure and an isolated polypeptide having the carboxy-terminal amino acid sequence of an alpha Connexin, or a conservative variant thereof, wherein the polypeptide does not include the full length alpha Connexin protein. | 09-12-2013 |
| 20130218789 | Systematic Approach to Enforcing Contiguity Constraint in Trajectory-based Methods for Combinatorial Optimization - A computer implemented method for enforcing geographic contiguity of an optimization method for redistricting is described. The method includes randomly grouping a data set of objects into geographically contiguous districts, optimizing the objects by iteratively moving one or more objects between neighboring districts, wherein a relationship of objects is analyzed in each district to determine a minimal set of objects that will move together to maintain contiguity between districts, and generating one or more solutions for the data set. | 08-22-2013 |
| 20130217066 | PIGMENT PRODUCTION BY LATEX-EMBEDDED MICROORGANISMS - A process is provided for the extraction of pigments from immobilized microorganisms. Pigment producing cells are immobilized and dried in a binder matrix, and pigments are recovered from the cells by liquid rinsing. Following release of the pigments, cellular metabolism of the microorganisms is revived in culture medium and pigments are regenerated. Pigments are then recovered from the immobilized cells by successive rounds of dehydration/rinsing/cell recovery. | 08-22-2013 |
| 20130216732 | Hydrogen Passivation Induced Dispersion of Carbon Nanotubes and Graphene - Methods for dispersing carbon nanoparticles in a media (e.g., an alcohol such as ethanol, a resin such as an epoxy, etc.) are generally provided. The method can include: immersing the carbon nanoparticles into the media, and ultrasonicating the media containing the carbon nanoparticles in the presence of hydrogen gas source. The carbon nanoparticles have dangling bonds on the surface of the carbon nanoparticles, such that the dangling bonds on the surface of adjacent carbon nanoparticles are covelantly bonded to each other. Upon ultrasonicating the media containing the carbon nanoparticles in the presence of hydrogen gas source (e.g., hydrogen gas), the dangling bonds on the surface of the carbon nanoparticles are replaced with carbon-hydrogen bonds. | 08-22-2013 |
| 20130164829 | Specific Gene Polymorphisms in Breast Cancer Diagnosis, Prevention and Treatment - A method for detecting a predisposition to breast cancer in a subject is provided, The method comprises detecting in a biological sample from the subject one or more polymorphisms in the sequence of CD44 gene, The presence of one or more polymorphisms in the sequence of CD44 gene indicates that the subject has a predisposition for developing breast cancer. | 06-27-2013 |
| 20130164536 | Porous Metal Oxide Particles and Their Methods of Synthesis - Methods are generally disclosed for synthesis of porous particles from a solution formed from a leaving agent, a surfactant, and a soluble metal salt in a solvent. The surfactant congregates to form a nanoparticle core such that the metal salt forms about the nanoparticle core to form a plurality of nanoparticles. The solution is heated such that the leaving agent forms gas bubbles in the solution, and the plurality of nanoparticles congregate about the gas bubbles to form a porous particle. The porous particles are also generally disclosed and can include a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm. The particle shell can be formed from a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm and defined by a metal salt formed about a surfactant core. | 06-27-2013 |
| 20130162999 | Classification Using Multivariate Optical Computing - Methods for in situ detection and classification of analyte within a fluid sample are provided. In one embodiment, the method can include: (a) continuously flowing the fluid sample through a multivariate optical computing device, wherein the multivariate optical computing device illuminates an area of the fluid sample as it flows through the multivariate optical computing device to elicit a continuous series of spectral responses; (b) continuously measuring the series of multivariate spectral responses as the fluid sample flows through the multivariate optical computing device; (c) detecting an analyte (e.g., phytoplankton) in the sample based on an multivariate spectral response of the plurality of spectral responses; and (d) classifying the analyte based on the multivariate spectral response generated by the analyte. | 06-27-2013 |
| 20130157308 | BIDIRECTIONAL PROMOTER REPORTER VECTOR FOR THE ANALYSIS OF DUAL REGULATORY ELEMENTS - A bidirectional expression vector is described that can be utilized to determine the existence and characteristics of bidirectional promoters. The bidirectional expression vector includes two different reporter genes in a head to head (5′ to 5′) arrangement. In addition, the bidirectional expression vector can include a polylinker region located between the heads of the two reporter genes that provides multiple cloning sites for nonexclusive examination of polynucleotide sequences. The vector can also include a splicing site and drug resistance. The bidirectional expression vector can be used to examine a polynucleotide sequence for the presence of divergent regulator regions and, following determination of a bidirectional promoter, can be utilized to further elucidate characteristics of the bidirectional promoter. | 06-20-2013 |
| 20130143396 | Pretreatment Method for Reduction and/or Elimination of Basal Plane Dislocations Close to Epilayer/Substrate Interface in Growth of SiC Epitaxial - Non-destructive pretreatment methods are generally provided for a surface of a SiC substrate with substantially no degradation of surface morphology thereon. In one particular embodiment, a molten mixture (e.g., including KOH and a buffering agent) is applied directly onto the surface of the SiC substrate to form a treated surface thereon. An epitaxial film (e.g., SiC) can then be grown on the treated surface to achieve very high (e.g., up to and including 100%) BPD to TED conversion rate close to the epilayer/substrate interface. | 06-06-2013 |
| 20130143303 | Bionanomaterials and Their Synthesis - The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed. | 06-06-2013 |
| 20130129829 | Encapsulation and Controlled Release of Small Molecules for Intracellular Delivery Using Thermally Responsive Nanocapsules - In accordance with certain embodiments of the present disclosure, a method for intracellular delivery of small molecules is provided. The method includes encapsulation of small molecules in a thermally responsive nanocapsule by decreasing the temperature of the nanocapsule to increase the permeability of the nanocapsule and allowing the small molecules to be suck into or diffuse into the nanocapsule. The nanocapsule is delivered into a cell by increasing the temperature of the nanocapsule. The small molecules are released from the nanocapsule into the cell in a controllable manner by cooling and heating treatments. | 05-23-2013 |
| 20130129275 | Acousto-Ultrasonic Sensor - In one aspect, the present subject matter is directed to a sensor. The sensor includes an encapsulated fiber optic sensor and a ring shaped structure. The encapsulated fiber optic sensor passes through the ring shaped structure. The ring shaped structure is configured to resonate at a predetermined frequency. | 05-23-2013 |
| 20130102539 | PEPTOIDS AND METHODS FOR TREATING ALZHEIMER'S DISEASE - Provided herein are peptoids capable of inhibiting or reversing amyloid β (Aβ) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at least two monomers with a side-chain having an arylalkyl group having the same chirality positioned such that the side-chains are on the same side of the peptoid. Also provided are methods of using the peptoids to inhibit or reverse aggregation of Aβ and methods of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD. | 04-25-2013 |
| 20130092143 | METHODS, WIRES, AND APPARATUS FOR SLICING HARD MATERIALS - Methods, wires, and apparatus for use in cutting (e.g., slicing) hard, brittle materials is provided. The wire can be a super-abrasive wire that includes a wire core and super-abrasive particles bonded to the wire core via a metal bonding layer. This wire, or another type of wire, can be used to slice workpieces useful for producing wafers. The workpieces can be aligned within a holder to produce wafers using the device and methods presently provided. The holder rotates about its central axis, which translates to workpieces moving in orbit around this axis. A single abrasive wire, or multiple turns of wire stretched tightly between wire guides, is then contacted with the rotating holder to slice the workpieces. | 04-18-2013 |
| 20130089882 | Chloroacetamidine Based Inhibitors and Activity Based Probes for the Protein Arginine Methytransferases - In accordance with certain embodiments of the present disclosure, a protein arginine methyltransferase inhibitor is provided. The inhibitor comprises an amino acid peptide joined to a chloroacetamidine warhead. | 04-11-2013 |
| 20130079336 | Treatment of Prolonged Status Epilepticus - Methods for terminating, preventing, and/or treating status epilepticus are generally provided. The method can include administering a prophylactically or therapeutically effective amount of stiripentol or a related compound thereof to an individual in need of treatment of status epilepticus. The individual can be in need of treatment of prolonged status epilepticus, refractory status epilepticus, and/or benzodiazepine-resistant status epilepticus. | 03-28-2013 |
| 20130068209 | METHODS, WIRES, AND APPARATUS FOR SLICING HARD MATERIALS - Methods, wires, and apparatus for use in cutting (e.g., slicing) hard, brittle materials is provided. The wire can be a super-abrasive wire that includes a wire core and super-abrasive particles bonded to the wire core via a metal bonding layer. This wire, or another type of wire, can be used to slice workpieces useful for producing wafers. The workpieces can be aligned within a holder to produce wafers using the device and methods presently provided. The holder rotates about its central axis, which translates to workpieces moving in orbit around this axis. A single abrasive wire, or multiple turns of wire stretched tightly between wire guides, is then contacted with the rotating holder to slice the workpieces. | 03-21-2013 |
| 20130056796 | Novel Method to Increase Breakdown Voltage of Semiconductor Devices - Methods of achieving high breakdown voltages in semiconductor devices by suppressing the surface flashover using high dielectric strength insulating encapsulation material are generally described. In one embodiment of the present invention, surface flashover in AlGaN/GaN heterostructure field-effect transistors (HFETs) is suppressed by using high dielectric strength insulating encapsulation material. Surface flashover in as-fabricated III-Nitride based HFETs limits the operating voltages at levels well below the breakdown voltages of GaN. | 03-07-2013 |
| 20130041198 | Highly Active Decomposition Catalyst for Low Carbon Hydrocarbon Production from Sulfur Containing Fuel - Methods for deriving a low-C hydrocarbon fuel from a high-C hydrocarbon fuel are generally provided. A catalytic material (e.g., an aluminosilicate and/or a zeolite) can be introduced to the high-C hydrocarbon fuel to produce a product stream comprising a low-C hydrocarbon fuel, and the low-C hydrocarbon fuel can be separated in the product stream from any remaining high-C hydrocarbon fuel. | 02-14-2013 |
| 20130041112 | Nanoparticles with Multiple Attached Polymer Assemblies and Use Thereof in Polymer Composites - Methods of synthesizing a binary polymer functionalized nanoparticle are generally provided. In one embodiment, a first anchoring compound is attached to a nanoparticle, and a first plurality of first monomers are polymerized on the first anchoring compound to form a first polymeric chain covalently bonded to the nanoparticle via the first anchoring compound. In another embodiment, a first polymeric chain can be attached to the nanoparticle, where the first polymeric chain has been polymerized prior to attachment to the nanoparticle. Thereafter, a second anchoring compound is attached to the nanoparticle, and a second plurality of second monomers are polymerized on the second anchoring compound to form a second polymeric chain covalently bonded to the nanoparticle via the second anchoring compound. Nanoparticles are also generally provided having multiple polymeric assemblies. | 02-14-2013 |
| 20130030072 | Synthesis of a Highly Crystalline, Covalently Linked Porous Network - Porous networks are described linked by boronates. Also described are processes for producing the porous networks. The porous networks are formed by reacting a polyboronic acid with itself or with a polydiol, a polydiamine, or a polyamino alcohol. The resulting boronate linkage is covalently bonded. The characteristics and properties of the resulting porous material can be varied and altered by changing the reactants and by incorporating functional groups into the reactants. Of particular advantage, the porous materials can be formed at or near atmospheric pressure and at low temperature in the presence of one or more solvents. | 01-31-2013 |
| 20130022720 | Methods of Treating a Water Sample or a Substrate to Remove Organic Compounds - Methods for treating fruits and/or vegetables to oxide any organic contaminates thereon are provided, using an aqueous solution. The aqueous solution can include a ferrous salt and an acid, and can be exposed to oxygen gas, allowing the organic contaminates to be oxidized via exposure to the aqueous solution and oxygen gas. Then, the outer surface of the fruits and/or vegetables can be washed to remove the aqueous solution. The aqueous solution can have a pH of about 4 to about 9, and can also be adjusted during the method. Methods are also disclosed for oxidizing organic compounds in an aqueous sample via measuring the pH of the aqueous sample; determining an appropriate chemical equation for oxidation based upon the pH measured; and thereafter, adjusting the pH of the aqueous sample. | 01-24-2013 |
| 20120302700 | NANOFILLED POLYMERIC NANOCOMPOSITES WITH TUNABLE INDEX OF REFRACTION - The present invention includes a method for preparing a nanoparticle filled nanocomposite material, the method including the steps of providing a plurality of nanoparticles. attaching a first layer of organic ligand to the nanoparticle via a phosphate or phosphonate linkage, covalently attaching a second layer of matrix compatible polymer to said first layer of organic ligand to produce modified nanoparticles, providing a polymer matrix and dispersing the modified nanoparticles in the polymer matrix, wherein the dispersement of the modified nanoparticles into the polymer matrix results in a nanocomposite material, and wherein the modified nanoparticles are modified such that the first layer is proximal to the nanoparticle and the second layer is distal to the nanoparticle. Also within the scope of the invention are modified nanoparticles, alternative nanocomposite materials and methods of making the same. | 11-29-2012 |
| 20120302646 | Use of Cannabidiol in the Treatment of Hepatitis - Cannabinoids are known to interact with CB1 and CB2 receptors expressed in the nervous and immune systems mediating a wide range of effects, including anti-inflammatory properties. However, cannabinoids that bind CB1 are also psychoactive thereby limiting their clinical use. Cannabidiol (CBD) is the most abundant nonpsychotropic plant cannabinoid but has not been studied as extensively as Δ | 11-29-2012 |
| 20120301512 | Tetrary Gene Delivery System for Gene Therapy and Methods of Its Use - Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core. | 11-29-2012 |
| 20120295292 | Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera - Methods for diagnosing disease that is characterized by an overabundance of citrullinated proteins such as colitis, rheumatoid arthritis, and/or malignant cancer in a subject are provided. The PAD protein activity level can be measured in a tissue sample (e.g., serum) of the subject and then compared to a control PAD protein activity range of a control group. A finding of an increased PAD protein activity level in the tissue sample of the subject compared to the PAD protein activity level of the control group is indicative of disease characterized by an overabundance of citrullinated proteins in the subject. | 11-22-2012 |
| 20120280414 | In-Process Monitoring for Composite Parts Quality Control Using Piezoelectric Wafer Active Sensors (PWAS) Technologies - Methods of forming a molded composite material are generally provided. A composite forming precursor (e.g., fibers and/or a resin material) can be applied onto a mold that includes a plurality of piezoelectric sensors embedded into the mold. The composite forming precursor can then be cured adjacent to the mold to form a molded composite material. During curing, the molded composite material can be monitored, using the piezoelectric sensors to detect any defects formed during curing. | 11-08-2012 |
| 20120278376 | SYSTEM AND METHOD FOR SPARSE MATRIX VECTOR MULTIPLICATION PROCESSING - Systems and methods for sparse matrix vector multiplication (SpMV) are disclosed. The systems and methods include a novel streaming reduction architecture for floating point accumulation and a novel on-chip cache design optimized for streaming compressed sparse row (CSR) matrices. The present disclosure is also directed to implementation of the reduction circuit and/or processing elements for SpMV processing into a personality for the Convey HC-1 computing device. | 11-01-2012 |
| 20120231443 | MICROCAPSULES FOR CELL MICROENCAPSULATION - In accordance with certain embodiments of the present disclosure, a method for formation of a microcapsule is described. The method includes encapsulating a cell in a microcapsule, the microcapsule having a diameter of less than about 100 μm. The method further includes coating the microcapsule with chitosan and alginate. | 09-13-2012 |
| 20120226295 | Fiber-Reinforced Laminated Hydrogel / Hydroxyapatite Nanocomposites - In accordance with certain embodiments of the present disclosure, a method for forming a laminated nanocomposite is provided. The method includes applying a hydrogel precursor solution to a first layer of poly(L-lactide) nanofiber mesh. A second layer of poly(L-lactide) nanofiber mesh is stacked on the first layer with at least a portion of the hydrogel precursor solution being situated between the first layer and the second layer. The method further includes compressing the first layer and second layer together wherein the first layer and second layer are crosslinked to one another by the hydrogel precursor solution to form a laminated nanocomposite. Furthermore, the laminate layers, prior to crosslinking, can be wrapped around a rod and crosslinked to form a laminated tubular nanocomposite. | 09-06-2012 |
| 20120225823 | Allosteric Modulation of the Dopamine Transporter Protein for the Treatment of HIV-1 Induced Neurologic Dysfunction - A method for increasing dopaminergic neurotransmission in a mammal in need of such treatment is provided. The method comprises disrupting Tat-DAT binding in the mammal. | 09-06-2012 |
| 20120225792 | Gene Expression Biomarkers in PAP Test Material for Assessing HPV Presence and Persistence - In accordance with certain embodiments of the present disclosure, a method for the diagnosis of persistent HR-HPV in an individual is provided. An expression level of at least one biomarker in a biological sample is determined. The expression level of the at least one biomarker is compared to an expression level of corresponding biomarker(s) in a comparative sample, wherein the comparative sample contains the at least one biomarker in a level indicative of persistent HR-HPV. Persistent HR-HPV infection is predicted in the individual based upon the comparison of the expression level of the at least one biomarker between the comparative sample and the biological sample. | 09-06-2012 |
| 20120214950 | Rosin-Derived Cationic Compounds and Polymers Along with Their Methods of Preparation - Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group. | 08-23-2012 |
| 20120213995 | Flexible Zn2SnO4/MnO2 Core/Shell Nanocable - Carbon Microfiber Hybrid Composites for High Performance Supercapacitor Electrodes - Methods for forming hybrid nanowires are provided via forming a plurality of conductive nanowires extending radially from a surface of a flexible microwire; and then forming a thin film shell layer around the conductive nanowires. The conductive nanowires can include a metal oxide, and the thin film shell layer can include a transition metal oxide. Prior to forming the plurality of conductive nanowires, a catalyst coating layer can be formed on the surface of the carbon microfiber. Hybrid structures are also provided, which can include a flexible microwire defining a surface; a plurality of conductive nanowires extending radially from the surface of the flexible microfiber; and a thin film shell layer surrounding each conductive nanowire. | 08-23-2012 |
| 20120202970 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 - Methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins are described. Methods include developing structure activity relationships for peptidic inhibitors followed by development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide similar structure activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified in an iterative computational and synthetic process facilitated through understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through synthesis and testing of truncated and mutated analogs of known PBD binding motifs. | 08-09-2012 |
| 20120171775 | MULTI-DIMENSIONAL INTEGRATED DETECTION AND ANALYSIS SYSTEM (MIDAS) BASED ON MICROCANTILVERS - The present invention is a multidimensional integrated detection and analysis system (MIDAS) for any gas or fluid that transfers or accepts electronic charge (including but not limited to CH | 07-05-2012 |
| 20120168687 | Polypyrrole and Silver Vanadium Oxide Composite - In one embodiment of the present disclosure, a composite electrode for a battery is provided. The composite electrode includes silver vanadium oxide present in an amount from about 75 weight percent to about 99 weight percent and polypyrrole present in an amount from about 1 weight percent to about 25 weight percent. | 07-05-2012 |
| 20120164672 | HIGH-THROUGHPUT IN VITRO TRANSLATION (CELL-LYSATE BASED) ASSAY FOR DETECTING QUORUM SENSING SIGNALS - A cell-lysate extract based assay reagent for detecting quorum sensing signals is generally provided, along with methods of making and using the same. The assay reagent generally includes a cell-lysate extract formed from a biosensor bacterium (e.g., | 06-28-2012 |
| 20120153243 | Neutron Scintillating Materials - Neutron scintillating materials are provided, including boron substitution scintillation materials, boron and Li substitution scintillation materials, and Gd-based substitution scintillation materials. | 06-21-2012 |
| 20120100613 | Compositions and Methods for the Modulation of Gene Expression in Plants - Compositions and methods for modulating nucleotide sequence expression, particularly for modulating gene expression in plants, are provided. The compositions comprise precursor RNA constructs for the expression of an RNA precursor. The precursor RNA construct comprises a promoter that is expressed in a plant cell driving the expression of a precursor RNA having a microRNA. The miRNA is complementary or partially complementary to a portion of a target gene or nucleotide sequence and function to modulate expression of the target sequence or gene. In this manner, the RNA precursor construct can be designed to modulate expression of any nucleotide sequence of interest, either an endogenous plant gene or alternatively a transgene. Transformed plants, tissues, cells and seeds are also provided. | 04-26-2012 |
| 20120095142 | Methods of Making Layered Mixed-Metal Phosphonates for High Dielectric Strength Polymer Nanocomposites - Mixed metal phosphonates are generally provided. The mixed metal phosphonate can generally have the composition: AB(RPO | 04-19-2012 |
| 20120094017 | Patterned Nanoparticle Assembly Methodology - Methods for creating a precision assembly of nanoparticles by controlled deposition from a colloidal fluid (e.g., a ferrofluid) are disclosed. The method can include assembling magnetic nanoparticles, fixing the nanoparticles in place, and then allowing the completed nanoparticle assembly to be washed and dried to remove unwanted process contaminants left in the assembly fluid while preserving the underlying nanoparticle assembly as designed. | 04-19-2012 |
| 20120077978 | Structure Based Design Of Inhibitors Of Human Thymidylate Synthase - A compound is provided having the chemical structure: | 03-29-2012 |
| 20120077757 | Methods for Affecting Homology-Directed DNA Double Stranded Break Repair - Disclosed herein are methods and composition for alteration of the presence, activity, or concentration of RNF138. Disclosed methods can be utilized to affect DNA double strand break repair. Methods and compositions can be utilized to alter RNF138 so as to prevent interaction between RNF138 and RAD51D. Specifically, methods can prevent RNF138-directed ubiquitylation of RAD51D, which is necessary for DNA double strand break repair. | 03-29-2012 |
| 20120068156 | InN Nanowire Based Multifunctional Nanocantilever Sensors - Sensor are generally provided that include a layer of silicon oxide on a portion of a n+ layer to form an uneven surface where the layer of silicon oxide defines a thicker region than an exposed portion of the n+ layer. First and second metal contacts can be on the layer of silicon oxide, with first and second nanowires extending respectively from a first base on the first metal contact and a second base on the second metal contact. The first nanowire and the second nanowire are connected together at an apex to form a v-shaped nanocantilever, wherein the apex is positioned over the exposed n+ layer, and wherein the nanowires comprise indium and nitrogen. Methods of fabricating such sensors, along with methods of their use, are also generally provided. | 03-22-2012 |
| 20120066841 | Methods And Compositions For Dislodging Debris Particles From A Substrate - Methods are provided for making a treatment composition by loading active components into a high pressure vessel and pressurizing the high pressure vessel with carbon dioxide to reach a pressure within the high pressure vessel of about 400 pounds per square inch to about 1,070 pounds per square inch. The active components can include a protein denaturant and a surfactant, and optionally an acaricide. In one particular embodiment, this method can be used to clean a substrate, by loading the substrate into the high pressure vessel prior to pressurizing with carbon dioxide. Methods are also provided for treating a substrate to clean it from dust mites by delivering dry ice particles to the substrate, and vacuuming the substrate. Treatment compositions are also generally provided. | 03-22-2012 |
| 20120041163 | Preparation of Cobaltocenium-Containing Monomers and Their Polymers - Methods of forming a cobaltocenium-containing polymer are provided through polymerizing a plurality of cobaltocenium-containing monomers via controlled radical polymerization or controlled ring-opening polymerization. Each cobaltocenium-containing monomer comprises a cobaltocenium moiety covalently connected to a polymerizable group. Cobaltocenium-containing monomers are also provided that include a cobaltocenium moiety covalently connected to a polymerizable group. Cobaltocenium-containing polymers are also generally provided, such as the polymers formed according to any of the methods or from any of the monomers discussed herein. Methods are also generally provided for exchanging an anion associated with a cobaltocenium side group of a cobaltocenium-containing polymer with a new anion. | 02-16-2012 |
| 20120035089 | REMOVAL OF BACTERIAL ENDOTOXINS - Methods of cleaning a medical device are provided via exposing the medical device to a compressed CO | 02-09-2012 |
| 20120013292 | Non-Intrusive Energy Harvesting Systems and Methods - In accordance with certain embodiments of the present disclosure, an energy harvesting system is provided. The system comprises a coil wound about a generally cylindrical shaped magnetic core having a first end and a second end. The coil includes wires that are wound in such a manner that the wires are generally parallel to the cylindrical shaped magnetic core axis. The cylindrical shaped magnetic core defines a core gap that extends parallel to the magnetic core axis. The cylindrical shaped magnetic core also defines an opening extending therethrough from the first end to the second end such that the cylindrical shaped magnetic core is configured to fit around current carrying conductor. | 01-19-2012 |
| 20120006509 | Nanofluids for Thermal Management Systems - A nanofluid is generally provided for use in a heat transfer system. The nanofluid can include nanoparticles suspended in a base liquid at a nanoparticle concentration in the nanofluid of about 0.01% to about 5% by volume. The nanoparticles can include zinc-oxide nanoparticles. The nanofluid for use in a heat transfer system can, in one embodiment, further include a surfactant. Thermal management systems configured to cool a computer having integrated circuits that generate heat during use are also provided. The thermal management system can include a zinc-oxide nanofluid circulated through a series of tubes via a pump such that heat produced by electronic components of the computer can be captured by the circulating nanofluid and then removed from the nanofluid by a radiator. | 01-12-2012 |
| 20110309303 | Up-Conversion White Light Phosphors - Light emitting devices that include an energy source configured to generate light energy and an up-conversion phosphor configured to emit light having a wavelength shorter than that of the light energy generated from the energy source are provided. The up-conversion phosphor comprises an ordered oxyfluoride compound having a formula: A | 12-22-2011 |
| 20110287713 | Wireless Power Transfer to Embedded Sensors - In certain embodiments of the present disclosure, a wireless sensor system is described. The wireless sensor system includes a near-field wireless power transfer component, at least one measurement sensor, and an antenna. The antenna is in communication with the measurement sensor and can transmit measurements from the measurement sensor. The near-field wireless power transfer component can wirelessly receive power to operate the measurement sensor. | 11-24-2011 |
| 20110281278 | High Throughput Assay for Discovering New Inhibitors of the GIRK1/4 Channel - In certain embodiments of the present disclosure, a method for determining an inhibitor of acetylcholine-activated potassium channel is described. The method includes incubating a cardiac cell in a solution comprising a test compound. The method further includes adding a muscarine (M2) receptor agonist to the cardiac cell in the solution and monitoring the cardiac cell for a change in membrane potential. A statistically insignificant change in the membrane potential following addition of the muscarine (M2) receptor to the solution signifies that the test compound is a K | 11-17-2011 |
| 20110259128 | Integrity Evaluation of Prestressed Concrete Girders - A novel and practical methodology that accounts for the specific mechanical features of a prestressed concrete girder (elastic stiffness, cracking moment, fully cracked inertia, and ultimate capacity) and allows the objective delimitation of its damage levels is presented. Results from this procedure show excellent correlation when compared to the experimentally defined damage thresholds. Also, the global integrity parameter is proposed as a new criterion for damage diagnosis and performance evaluation of prestressed concrete girders within the intermediate and heavy damage zones, showing excellent correlation with the experimental information obtained during testing. | 10-27-2011 |
| 20110257365 | Cyclin Based Inhibitors of CDK2 and CDK4 - Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation. | 10-20-2011 |
| 20110236256 | Cold Sterilization of Tissue Engineering Scaffolds with Compressed Carbon Dioxide - Methods for sterilizing a biocompatible hydrogel polymer are provided via treating the biocompatible hydrogel polymer with a supercritical CO | 09-29-2011 |
| 20110232683 | Methods and Compositions for Eliminating Allergens and Allergen-Producing Organisms - Methods are provided for making a treatment composition by loading active components into a high pressure vessel and pressurizing the high pressure vessel with carbon dioxide to reach a pressure within the high pressure vessel of about 400 pounds per square inch to about 1,070 pounds per square inch. The active components can include a protein denaturant and a surfactant, and optionally an acaricide. In one particular embodiment, this method can be used to clean a substrate, by loading the substrate into the high pressure vessel prior to pressurizing with carbon dioxide. Methods are also provided for treating a substrate to clean it from dust mites by delivering dry ice particles to the substrate, and vacuuming the substrate. Treatment compositions are also generally provided. | 09-29-2011 |
| 20110218099 | Reversible Hydrogen Storage Materials - In accordance with the present disclosure, a process for synthesis of a complex hydride material for hydrogen storage is provided. The process includes mixing a borohydride with at least one additive agent and at least one catalyst and heating the mixture at a temperature of less than about 600° C. and a pressure of H | 09-08-2011 |
| 20110189582 | Mixed Ionic and Electronic Conductor Based on Sr2Fe2-x MoXO6 Perovskite - In accordance with the present disclosure, a method for fabricating a symmetrical solid oxide fuel cell is described. The method includes synthesizing a composition comprising perovskite and applying the composition on an electrolyte support to form both an anode and a cathode. | 08-04-2011 |
| 20110184202 | SURFACE ENHANCED RAMAN SPECTROSCOPY USING SHAPED GOLD NANOPARTICLES - Surface enhanced Raman scattering (SERS) spectra of 4-mercaptobenzoic acid (4-MBA) self-assembled monolayers (SAMs) on gold substrates is presented for SAMs onto which gold nanoparticles of various shapes have been electrostatically immobilized. SERS spectra of 4-MBA SAMs are enhanced in the presence of immobilized gold nanocrystals by a factor of 10 | 07-28-2011 |
| 20110171096 | High Throughput Synthesis of Carbide Nanostructures from Natural Biological Materials - Methods of forming one-dimensional carbide nanostructures are provided. In one embodiment, a carbide forming mixture (e.g., including a noncarbon element source, a catalyst, and a solvent) is applied to a porous plant template (e.g., cotton fibers, bamboo fibers, wood fibers, leaf fibers, straw fibers, or mixtures thereof). The porous plant template can then be dried to evaporate the solvent, and heated to a growth temperature of about 1000° C. or more (e.g., about 1050° C. to about 1300° C.) to grow the one-dimensional carbide nanostructures on the porous plant template. | 07-14-2011 |
| 20110168572 | Composite Mixed Carbonate Ion and Electron Conducting Membranes and Reactant Gas Assisted Chemical Reactors for CO2 Separation and Capture - The present disclosure relates to a system for carbon dioxide seperation and capture. The system includes a porous metal membrane comprising Ni, Ag, or combinations thereof and having molten carbonate within the pores. A CO | 07-14-2011 |
| 20110151542 | Bionanomaterials and Their Synthesis - The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed. | 06-23-2011 |
| 20110137903 | OPTIMIZATION AND VISUAL CONTROLS FOR REGIONALIZATION - In accordance with certain embodiments of the present disclosure, a regionalization method is disclosed. The method includes inputting a data set into a computer. The method further includes utilizing the computer to perform contiguity-constrained hierarchical clustering on the data set to generate two regions and performing a fine-tuning procedure on the two regions with the computer to iteratively modify the boundaries between the two regions. | 06-09-2011 |
| 20110137062 | SURFACE ENHANCED RAMAN SPECTROSCOPY USING SHAPED GOLD NANOPARTICLES - Surface enhanced Raman scattering (SERS) spectra of 4-mercaptobenzoic acid (4-MBA) self-assembled monolayers (SAMs) on gold substrates is presented for SAMs onto which gold nanoparticles of various shapes have been electrostatically immobilized. SERS spectra of 4-MBA SAMs are enhanced in the presence of immobilized gold nanocrystals by a factor of 10 | 06-09-2011 |
| 20110090342 | MULTI-MODE IMAGING IN THE THERMAL INFRARED FOR CHEMICAL CONTRAST ENHANCEMENT - A system and method for analyzing a sample is disclosed. At least a portion of the sample is illuminated with modulated light from a light source, such as an infrared light source. Infrared energy from the sample is monitored with an infrared detector as the sample is being illuminated with the modulated light. The AC response of the infrared energy is analyzed to determine at least one of emission data or reflection data about the sample. The emission data or the reflection data can be used to enhance chemical contrast between varying substances on the sample. | 04-21-2011 |
| 20110086979 | Polymers Derived from Rosin and Their Methods of Preparation - Methods of forming polymer material from rosin-derived material are provided. For example, a plurality of functionalized resin acids having a polymerizable functional group via controlled living polymerization can be polymerized into the polymeric material such that each polymer defines a functional end group and the polymeric material has a polydispersity index of about 1 to about 1.5. The resulting polymers are also described. | 04-14-2011 |
| 20110086068 | Compositions and Methods for Tissue Engineering, Tissue Regeneration and Wound Healing - In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel structure and an isolated polypeptide having the carboxy-terminal amino acid sequence of an alpha Connexin, or a conservative variant thereof, wherein the polypeptide does not include the full length alpha Connexin protein. | 04-14-2011 |
| 20110059003 | METHODS OF GROWING A SILICON CARBIDE EPITAXIAL LAYER ON A SUBSTRATE TO INCREASE AND CONTROL CARRIER LIFETIME - A method of growing an epitaxial layer on a substrate is generally provided. According to the method, the substrate is heated in a chemical vapor deposition chamber to a growth temperature in the presence of a carbon source gas, then the epitaxial layer is grown on the substrate at the growth temperature, and finally the substrate is cooled in a chemical vapor deposition chamber to at least about 80% of the growth temperature in the presence of a carbon source gas. Substrates formed from this method can have a carrier lifetime between about 0.25 μs and about 9.9 μs. | 03-10-2011 |
| 20110052487 | Hydrolysis Reactor for Hydrogen Production - In accordance with certain embodiments of the present disclosure, a method for hydrolysis of a chemical hydride is provided. The method includes adding a chemical hydride to a reaction chamber and exposing the chemical hydride in the reaction chamber to a temperature of at least about 100° C. in the presence of water and in the absence of an acid or a heterogeneous catalyst, wherein the chemical hydride undergoes hydrolysis to form hydrogen gas and a byproduct material. | 03-03-2011 |
| 20110025397 | DRIVER CIRCUIT FOR GALLIUM NITRIDE (GaN) HETEROJUNCTION FIELD EFFECT TRANSISTORS (HFETs) - A driver circuit and integrated circuit implementation of a driver circuit for driving a GaN HFET device is disclosed. The driver circuit includes a resonant drive circuit having an LC circuit with an inductance and a capacitance. The capacitance of the LC circuit includes the gate-source capacitance of the GaN HFET device. The driver circuit further includes a level shifter circuit configured to receive a first signal and to amplify the first signal to a second signal suitable for driving a GaN HFET device. The resonant drive circuit is controlled based at least in part on the second signal such that the resonant drive circuit provides a first voltage to the GaN HFET device to control the GaN HFET device to operate in a conducting state and to provide a second voltage to the GaN HFET device to control the GaN HFET device to operate in a non-conducting state. | 02-03-2011 |
| 20100327494 | Electrospun Fibrous Three-Dimensional Scaffolds with Well-Defined Pore Geometry - In accordance with certain embodiments of the present disclosure, a method for fabricating multi-layer fibrous scaffolds with a well-defined pore geometry is provided. The method includes electrospinning generally parallel rows of biodegradable synthetic polymer fibers onto a collector plate, wherein the fibers of each generally parallel row on the collector plate are generally aligned as they are electrospun onto the collector plate. The collector plate is rotated and additional generally parallel rows of biodegradable synthetic polymer fibers are electrospun onto the collector plate, wherein the additional fibers on the collector plate are generally aligned as they are electrospun onto the collector plate and a multi-layer scaffold is formed. The process can be continued to form a multi-layer fibrous scaffold with macropores of well-defined geometry. | 12-30-2010 |
| 20100322979 | Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles - In accordance with certain embodiments of the present disclosure, a self-assembling biodegradable nanoparticle is provided. The nanoparticle includes a degradable synthetic polymer chain, a sequence of non-polar amino acids, and a sequence of ionic amino acids. The nanoparticle has a diameter of from about 50 nm to about 150 nm. | 12-23-2010 |
| 20100311036 | Methods for Augmentation of Cell Cryopreservation - In accordance with certain embodiments of the present disclosure, a method for cryopreserving a cell is described. The method includes encapsulating a cell in a microcapsule, the microcapsule having a diameter of less than about 100 μM. The method further includes vitrifying the encapsulated cell in a vitrifying solution comprising a cryoprotectant, wherein the cell is cooled at a rate of equal to or greater than 30,000° C./min and the cryoprotectant is present at a concentration of less than or equal to 1.5 M. | 12-09-2010 |
| 20100305741 | Thin Film Interference Filter and Bootstrap Method for Interference Filter Thin Film Deposition Process Control - A thin film interference filter system includes a plurality of stacked films having a determined reflectance; a model monitor curve; and a topmost layer configured to exhibit a wavelength corresponding to one of the determined reflectance or the modeled monitor curve. The topmost layer is placed on the plurality of stacked films and can he a low-index film such as silica or a high index film such as niobia. | 12-02-2010 |
| 20100288472 | NANOFLUIDS FOR THERMAL MANAGEMENT SYSTEMS - A nanofluid is generally provided for use in a heat transfer system. The nanofluid can include nanoparticles suspended in a base liquid at a nanoparticle concentration in the nanofluid of about 0.01% to about 5% by volume. The nanoparticles can include zinc-oxide nanoparticles. The nanofluid for use in a heat transfer system can, in one embodiment, further include a surfactant. | 11-18-2010 |
| 20100284977 | Expression of Anti-Nociceptive Compounds from Endogenously Regulated Promoters - Expression of anti-nociceptive compounds under the control of endogenously regulated promoters is disclosed. Methods and materials can be used to modify nociception, the process activated by detection of noxious stimuli. The activity of endogenous promoters employed is up-regulated following nociception in animal models of pain. Thus, expression of anti-nociceptive compounds, e.g., proteins, antisense RNAs or micro RNAs, under the control of these promoters can occur in an auto-regulatory, demand-driven manner. Delivery to neurons activated during pain transmission of disclosed expression cassettes containing up-regulated promoters to drive expression of anti-nociceptive compounds can be useful for pain management. | 11-11-2010 |
| 20100276699 | Silicon Carbide and Related Wide Bandgap Semiconductor Based Optically-Controlled Power Switching Devices - An optically-controlled power switch for use as an electrical switch is generally provided. The device can include a wide bandgap semiconducting material defining a stack having a p-n junction, a metal mask overlying the top surface of the stack and defining at least one opening to allow light to pass through the metal mask; a first lead wire connected to the metal stack; and a second lead wire connected to the bottom surface of the stack. | 11-04-2010 |
| 20100262390 | SYSTEM AND METHOD FOR MODAL IDENTIFICATION USING SMART MOBILE SENSORS - Systems and methods for determining spatially dense dynamic properties of a structure are disclosed. In particular, spatially dense mode shapes are determined using acceleration records collected when one or several sensors are moving. The mobile sensor gathers vibration response data for the structure as the mobile sensor moves over the structure. The vibration response data is used to extract a fine grid of modal coordinates with a reduced number of sensors and without requiring mode shape expansion. The high spatially dense mode shapes can be included as part of accurate numerical models for the structure that can be used for a variety of purposes, such as damage detection, earthquake engineering, wind engineering, and other suitable purposes. | 10-14-2010 |
| 20100223979 | Systems and Methods for Measurement of Gas Permeation Through Polymer Films - In accordance with one embodiment of the present disclosure, a system for determining the rate of gas permeation through a film is described. The system comprises a continuous flow permeation cell, a mass spectrometer, a test gas source, and a carrier gas source. The continuous flow permeation cell comprises a supply chamber in communication with the test gas source and a receiving chamber in communication with the carrier gas source and the mass spectrometer. The supply chamber is configured to be separated from the receiving chamber by a test film such that when a test gas stream is fed to the supply chamber from the test gas source and a carrier gas stream is fed to the receiving chamber from the carrier gas source. At least a portion of the test gas stream permeates from the supply chamber through the test film to the receiving chamber and mixes with the carrier gas stream and the mixture flows to the mass spectrometer. The mass spectrometer is utilized to determine the rate of permeation of the test gas stream through the film. | 09-09-2010 |
| 20100221351 | Controlled Drug Delivery Using a Thermally Responsive Nanocapsule to Augment Cryoablation - In accordance with certain embodiments of the present disclosure, A method for intracellular delivery of cytotoxin in combination with cyoablation is provided. The method includes encapsulation of one or more cytotoxins in a thermally responsive nanocapsule by decreasing the temperature of the nanocapsule to increase the permeability of the nanocapsule whereby the one or more cytotoxins are sucked into or diffuse into the nanocapsule. The temperature of the nanocapsule is increased and the nanocapsule is delivered into a cell. Cryoablation is performed in proximity to the cell resulting in the release of the one or more cytotoxins from the nanocapsule into the cell. | 09-02-2010 |
| 20100216924 | Layered Mixed-Metal Phosphonates for High Dielectric Strength polymer Nanocomposites - Mixed metal phosphonates are generally provided. The mixed metal phosphonate can generally have the composition: AB(RPO | 08-26-2010 |
| 20100207126 | MOS-Driver Compatible JFET Structure with Enhanced Gate Source Characteristics - A MOSFET driver compatible JFET device is disclosed. The JFET device can include a gate contact, a drain contact, and a source contact. The JFET device can further include a first gate region of semiconductor material adjacent the gate contact and a second region of semiconductor material adjacent the first gate region. The first gate region and the second gate region can form a first p-n junction between the first gate region and the second gate region. The JFET device can further include a channel region of semiconductor material adjacent the source contact. The channel region and the second gate region can form a second p-n junction between the second gate region and the channel region. | 08-19-2010 |
| 20100203148 | Encapsulation and Controlled Release of Small Molecules for Intracellular Delivery Using Thermally Responsive Nanocapsules - In accordance with certain embodiments of the present disclosure, a method for intracellular delivery of small molecules is provided. The method includes encapsulation of small molecules in a thermally responsive nanocapsule by decreasing the temperature of the nanocapsule to increase the permeability of the nanocapsule and allowing the small molecules to be suck into or diffuse into the nanocapsule. The nanocapsule is delivered into a cell by increasing the temperature of the nanocapsule. The small molecules are released from the nanocapsule into the cell in a controllable manner by cooling and heating treatments. | 08-12-2010 |
| 20100195105 | IMPROVED STABILITY FOR OPTICAL COMPUTING SYSTEM - The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. Temperature within the analysis system is monitored and the output signals of the optical detectors are compensated or corrections are made within the analysis calculations to compensate or correct for the system temperature. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass. | 08-05-2010 |
| 20100190233 | M13 Bacteriophage as A Chemoaddressable Nanoparticle for Biological and Medical Applications - Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding. | 07-29-2010 |
| 20100187545 | SELECTIVELY DOPED SEMI-CONDUCTORS AND METHODS OF MAKING THE SAME - The present invention is generally directed to methods of selectively doping a substrate and the resulting selectively doped substrates. The methods include doping an epilayer of a substrate with the selected doping material to adjust the conductivity of either the epilayers grown over a substrate or the substrate itself. The methods utilize lithography to control the location of the doped regions on the substrate. The process steps can be repeated to form a cyclic method of selectively doping different areas of the substrate with the same or different doping materials to further adjust the properties of the resulting substrate. | 07-29-2010 |
| 20100185864 | Multi-Dimensional Credentialing Using Veiled Certificates - In accordance with certain embodiments of the present disclosure, a method for creating a veiled certificate is provided. The method comprises requesting a certificate from a regulator by sending a message with a digital signature of the message signed by the owner. The message comprises an owner's veiled certificate token, the veiled certificate token comprising an encrypted version of the owner's identification data and the owner's identification public key for the certificate. The message further comprises the identification public key, the whole message being encrypted using the regulator's external public key. The certificate request is validated by verifying the sender's identity through validation of the digital signature using the owner's external public key and verifying the veiled certificate token using the individual' external public key. A veiled certificate is created by combining the veiled certificate token, identification public key and digitally signing the veiled certificate with the regulator's private key, wherein the owner's identification information is inaccessible from the veiled certificate, except to the certificate owner. | 07-22-2010 |
| 20100166885 | Resuscitation Fluid - The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described. | 07-01-2010 |
| 20100155218 | Novel Photocatalysts that Operate Under Visible Light - Semiconductor surfaces are generally provided that include a photocatalyst compound of at least one alkaline earth metal combined with bismuth and oxygen to form a bismuth oxide having a structure of A | 06-24-2010 |
| 20100151506 | Chloroacetamidine Based Inhibitors and Activity Based Probes for the Protein Arginine Methytransferases - In accordance with certain embodiments of the present disclosure, a protein arginine methyltransferase inhibitor is provided. The inhibitor comprises an amino acid peptide joined to a chloroacetamidine warhead. | 06-17-2010 |
| 20100143721 | POROUS METAL OXIDE PARTICLES AND THEIR METHODS OF SYNTHESIS - Methods are generally disclosed for synthesis of porous particles from a solution formed from a leaving agent, a surfactant, and a soluble metal salt in a solvent. The surfactant congregates to form a nanoparticle core such that the metal salt forms about the nanoparticle core to form a plurality of nanoparticles. The solution is heated such that the leaving agent forms gas bubbles in the solution, and the plurality of nanoparticles congregate about the gas bubbles to form a porous particle. The porous particles are also generally disclosed and can include a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm. The particle shell can be formed from a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm and defined by a metal salt formed about a surfactant core. | 06-10-2010 |
| 20100136694 | Cone-Shaped Adapter for a Gene Gun - A cone-shaped adapter for attachment to a muzzle of a gene gun is generally provided. The cone-shaped adapter comprises sidewalls that taper from a base plane at one end and to an apex aperture at an opposite end and a fitting. The sidewalls form a base angle of from about 85° to about 45° with the base plane. The fitting is attached to the sidewalls at the base plane and is configured to connect the cone-shaped adapter to the muzzle of the gene gun. Methods of using the cone-shaped adapter with a gene gun are also provided. | 06-03-2010 |
| 20100132469 | Nano-PWAS: Structurally Integrated Thin-Film Active Sensors for Structural Health Monitoring - In an exemplary configuration, a system for structural health monitoring is provided. The system includes a battery-less nano-PWAS device, the device comprising an array of nano-PWAS transducers and a tag antenna. | 06-03-2010 |
| 20100125173 | Systems and Methods for Determining a Probability of Pulmonary Embolism in an Individual - In one embodiment, a method for determining a probability of pulmonary embolism in an individual is provided. The method includes collecting data about the individual that relates to a plurality of predefined variables, wherein each of the predefined variables has a predefined regression coefficient. A risk of the individual having a pulmonary embolism is predicted by applying a regression model to the data, the regression model being calculated by utilizing the predefined regression coefficients of the predefined variables. | 05-20-2010 |
| 20100112072 | Controllable Virus/Protein Assemblies and Methods of Making the Same - Methods of forming a bionanocomposite defining a shell and a core are generally provided along with the bionanocomposites themselves. The method includes non-covalently attaching biomacromolecules about a polymeric core such that the biomacromolecules cover at least about at least about 50% of the surface area of the polymeric core to form a shell. The polymeric core includes a polymer having pyridine functional groups. In one particular embodiment, the biomacromolecules can be attached to the polymeric core by combining an organic solution containing the polymer in an organic solvent with an aqueous solution containing the biomacromolecules to form an emulsion, mixing the emulsion, and removing the organic solvent. | 05-06-2010 |
| 20100102359 | NOVEL FABRICATION TECHNIQUE FOR HIGH FREQUENCY, HIGH POWER GROUP III NITRIDE ELECTRONIC DEVICES - Fabrication methods of a high frequency (sub-micron gate length) operation of AlInGaN/InGaN/GaN MOS-DHFET, and the HFET device resulting from the fabrication methods, are generally disclosed. The method of forming the HFET device generally includes a novel double-recess etching and a pulsed deposition of an ultra-thin, high-quality silicon dioxide layer as the active gate-insulator. The methods of the present invention can be utilized to form any suitable field effect transistor (FET), and are particular suited for forming high electron mobility transistors (HEMT). | 04-29-2010 |
| 20100086607 | Self-Assembled Biodegradable Nanoparticles for Medical and Biological Applications - A method for forming a biodegradable composition that self-assembles into nanoparticles is provided. The method includes reacting N,N′-Disuccinimidyl carbonate with hydroxyl end-groups of poly(lactide-co-fumarate) to form a composition comprising succinimide-terminated poly(lactide-co-fumarate). | 04-08-2010 |
| 20100084784 | Fabrication of Biomimetic Scaffolds with Well-Defined Pore Geometry by Fused Deposition Modeling - A method for fabrication of a scaffold by fused deposition modeling is provided. The method includes forming a sacrificial mold with fused deposition modeling, the sacrificial mold comprising a dissolvable material. The method further includes infusing the sacrificial mold with a biodegradable composition and applying a solvent to the biodegradable composition infused sacrificial mold to dissolve the sacrificial mold and leave a scaffold formed from the biodegradable composition. | 04-08-2010 |
| 20100079598 | Robust Stereo Calibration System and Method for Accurate Digital Image Correlation Measurements - A stereo calibration method is proposed to calibrate an interface's shape and position when the measurement system is in one media and measures deformation and strain of an object that is submerged in a different media. After the interface's shape and position are modeled by parameters, an explicit model of object points as measurement is established taking account of refraction happening at the interface. Efficiency and convergence are assured by using measurement of object points to acquire initial estimates for refraction angles at the interface. Then, an optimization method is performed to get the optimized value of interface parameters. Last, based on the resulting interface parameters, 3-dimensional positions of object points in all the subsequent measurement could be reconstructed accurately. Therefore, the distortion induced by refraction in the measurement is corrected. Numerical simulations of the proposed calibration process confirm that it is both robust and accurate for a range of experimental conditions, even in the presence of Gaussian noise in the measurement. | 04-01-2010 |
| 20100063382 | Specific Gene Polymorphisms in Breast Cancer Diagnosis, Prevention and Treatment - A method for detecting a predisposition to breast cancer in a subject is provided. The method comprises detecting in a biological sample from the subject one or more polymorphisms in the sequence of CD44 gene. The presence of one or more polymorphisms in the sequence of CD44 gene indicates that the subject has a predisposition for developing breast cancer. | 03-11-2010 |
| 20100042338 | Structural Health Monitoring Apparatus and Methodology - Disclosed is an apparatus and methodology for structural health monitoring (SHM) in which smart devices interrogate structural components to predict failure, expedite needed repairs, and thus increase the useful life of those components. Piezoelectric wafer active sensors (PWAS) are applied to or integrated with structural components and various data collected there from provide the ability to detect and locate cracking, corrosion, and disbanding through use of pitch-catch, pulse-echo, electro/mechanical impedance, and phased array technology. Stand alone hardware and an associated software program are provided that allow selection of multiple types of SHM investigations as well as multiple types of data analysis to perform a wholesome investigation of a structure. | 02-18-2010 |
| 20100038336 | Nursing Bottle Apparatus for Improvement of Suckling - In accordance with certain embodiments of the present disclosure, a nursing bottle is provided. The bottle includes a body having a hollow interior and defining an upper opening. The bottle further includes a nipple joined to the body and disposed over the upper opening. The bottle also includes a means for generating negative pressure within a portion of the interior of the body. | 02-18-2010 |
| 20100032647 | UTLRAVIOLET LIGHT EMITTING DEVICES AND METHODS OF FABRICATION - An ultraviolet light emitting semiconductor chip, its use in a LED, and methods of its fabrication are disclosed. The semiconductor chip can include a buffer layer of Al | 02-11-2010 |
| 20100016711 | Membrane-Deformation Mapping Technique - In accordance with one embodiment of the present disclosure, a method for deformation mapping of a tissue is provided. The method includes utilizing a device to measure transient three-dimensional deformations in a tissue sample. The device comprises a non-contacting, high-speed stereo imaging apparatus and a mechanism for digital image correlation. The method further includes identifying regions of the tissue that are prone to damage based upon the deformations. | 01-21-2010 |
| 20090320683 | High Efficiency, Non-Toxic Scrubbing System and Method for Removing Carbon Dioxide from a Gas - Scrubbing systems and methods for removing carbon dioxide from a gas are provided. The scrubbing system can include a scrubber defining a vertically oriented tubing assembly, a gas inlet and a gas outlet. The tubing assembly has a tank section, a reduced diameter section, and an expansion section such that the expansion section is positioned above the reduced diameter section and the reduced diameter section is positioned above the tank section. An aqueous liquid-phase scrubbing media is contained within the tank section. The scrubbing system can further include a water bath configured to receive the CO | 12-31-2009 |
| 20090306153 | SYNTHESIS AND USE OF NOVEL INHIBITORS AND INACTIVATORS OF PROTEIN ARGININE DEIMINASES - In one embodiment of the present disclosure, an inactivator of protein arginine deiminase 4 is disclosed. The inactivator includes: (I) and x includes F; Cl, and H, y includes OH and NH | 12-10-2009 |
| 20090302236 | Inorganic Luminescent Phosphor Materials for Lighting - A light emitting device comprising a light producing element configured to generate ultraviolet light having a wavelength of from about 250 nm to about 400 nm and a self-activating phosphor comprising an ordered oxyfluoride compound is provided. The nitrogen-free or nitrogen-containing ordered oxyfluoride compound has a formula: | 12-10-2009 |
| 20090292306 | Inflatable Gastric Device and Methods Relating to the Same - In accordance with certain embodiments of the present disclosure, a device for treatment of obesity in a patient is provided. The device comprises an inflatable material and a flexible ring-shaped member. The inflatable material is joined to the flexible ring-shaped member to define a space that is configured to be expanded when the device is inflated to a generally torus shape, the ring-shaped member defining an opening therethrough. | 11-26-2009 |
| 20090258941 | USE OF FUSAROCHROMANONE AND ITS DERIVATIVES IN THE DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES - A method of photodynamic therapy to treat diseased cells in an animal is generally provided. According to the method, 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof is administered to the animal such that the 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof accumulates in the diseased cells. Then, the diseased cells containing 5-amino-2,2-dimethyl-6-[3′-(R,S)amino-4′-hydroxy-butan-1-one]-2,3-dihydro-4H-1-benzopyran-4-one or an analog thereof is exposed to light energy (e.g., ultraviolet light). | 10-15-2009 |
| 20090250613 | Chemically-Selective Detector and Methods Relating Thereto - In accordance with certain embodiments of the present disclosure, a method for adjusting the spectral detectivity of a thermal detector is described. The method includes coating the light sensitive portion of a thermal detector with a first material to reduce the response of the detector. The first material is coated with a second material that is thermally thin and has spectral absorption characteristics. The second material is coated with a third material that is thermally thick, whereby the spectral absorbance of the second material as filtered by the third material primarily determines the thermal conversion of the thermal detector. | 10-08-2009 |
| 20090247186 | Dynamic Localization Using Geographical Information Systems - In accordance with certain embodiments of the present disclosure, a system to determine the geographic location of a mobile device is described. The system comprises a mobile device. The mobile device comprises a measurement module, the measurement module being capable of detecting information including the direction and acceleration of the mobile device, the mobile device further being capable of determining the received signal strength from at least one access point. The system further comprises at least one access point being in communication with the mobile device. The at least one access point comprises a database module and a location determination module, the database module including data from a geographic information system, the data relating to the potential geographic locations adjacent to the at least one access point, the location determination module being capable of determining the geographic location of the mobile device based on information from the measurement module, received signal strength by the mobile device, and data from the database module. | 10-01-2009 |
| 20090246789 | Gene Mutation Profiling of CSMD1 - A method for assessing risk of node-positive colorectal cancer in an individual is described. The method includes detecting mutations in CSMD1 genes in a tumor sample from the individual, the mutations being associated with increased risk of node-positive colorectal cancer. | 10-01-2009 |
| 20090240433 | System for Determining Risk of Loss to Coastal Wetlands - In accordance with certain embodiments of the present disclosure, a system for determining risk of loss to a wetland habitat is provided. The system comprises a computer, the computer configured to receive light detection and ranging data about a wetland habitat elevation and calculate the frequency distribution of the wetland habitat elevation based on the light detection and ranging data. The computer is further configured to calculate a skewness statistic based on the frequency distribution of the wetland habitat elevation, the skewness statistic being negative, zero, or positive. The computer is configured to calculate risk of loss to the wetland habitat by utilizing the skewness statistic. | 09-24-2009 |
| 20090220682 | CATALYSTS FOR FUEL CELL APPLICATIONS USING ELECTROLESS DEPOSITION - The present disclosure is directed to a process for electroless deposition of metal atoms on an electrode. The process includes treating a carbon-containing support by contacting the carbon-containing support with a treatment, impregnating the carbon-containing support with a precursor metal component to form seed sites on the carbon-containing support, and depositing metal atoms on the seed sites through electroless deposition by contacting the carbon-containing support with a metal salt and a reducing agent. | 09-03-2009 |
| 20090219597 | OPTICAL ANALYSIS SYSTEM AND OPTICAL TRAIN - A multivariate optical computing and analysis system includes a light source configured to radiate a first light along a first ray path; a modulator disposed in the first ray path, the modulator configured to modulate the first light to a desired frequency; a spectral element disposed proximate the modulator, the spectral element configured to filter the first light for a spectral range of interest of a sample; a cavity disposed in communication with the spectral element, the cavity configured to direct the first light in a direction of the sample; a tube disposed proximate the cavity, the tube configured to receive and direct a second light generated by a reflection of the first light from the sample, the tube being further configured to separate the first and second lights; a beamsplitter configured to split the second light into a first beam and a second beam; an optical filter mechanism disposed to receive the first beam, the optical filter mechanism configured to optically filter data carried by the first beam into at least one orthogonal component of the first beam; and a detector mechanism in communication with the optical filter mechanism to measure a property of the orthogonal component to measure the data. | 09-03-2009 |
| 20090219539 | OPTICAL ANALYSIS SYSTEM FOR DYNAMIC REAL-TIME DETECTION AND MEASUREMENT - A method of real-time processing and monitoring comprises the steps of blending a material of interest (e.g., an active pharmaceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element ( | 09-03-2009 |
| 20090219538 | METHOD OF HIGH-SPEED MONITORING BASED ON THE USE OF MULTIVARIATE OPTICAL ELEMENTS - A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying information about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element ( | 09-03-2009 |
| 20090219512 | OPTICAL ANALYSIS SYSTEM AND ELEMENTS TO ISOLATE SPECTRAL REGION - A method of selecting components for a multivariate optical computing and analysis system to isolate a spectral region includes selecting a spectral region of interest; selecting a spectral element with a predetermined transmission characteristic to control a spectral range of an illumination source; illuminating a sample with the illumination source; and analyzing an optical frequency returned by the sample relative to the spectral region of interest. | 09-03-2009 |
| 20090216504 | SELECTING SPECTRAL ELEMENTS AND COMPONENTS FOR OPTICAL ANALYSIS SYSTEMS - Methods of selecting spectral elements and system components for a multivariate optical analysis system include providing spectral calibration data for a sample of interest; identifying a plurality of combinations of system components; modeling performance of a pilot system with one of the combinations of system components; determining optimal characteristics of the pilot system; and selecting optimal system components from among the combinations of system components. | 08-27-2009 |
| 20090191642 | Compositions, Systems, and Methods for Continuous Glucose Monitoring - A polymeric sensing fluid for detecting the presence of glucose and systems and methods of its use are generally disclosed. The polymeric sensing fluid includes a polymer in a solvent (e.g., an aqueous solvent). The polymer has a plurality of boronic acid moieties extending from its polymeric backbone. As such, the polymeric sensing fluid is configured to increase in viscosity upon addition of glucose due to crosslinking between the boronic acid moieties of the polymer and glucose. | 07-30-2009 |
| 20090188319 | Localized Cartesian Electric Field Excitation within a Continuous Dielectric Medium - A piezoelectric sensor having a plurality of electrodes deposited on a single surface of the dielectric medium is generally provided. The plurality of electrodes can define a plurality of square-shaped electrodes forming a grid on the first surface of the dielectric medium while the second electrode defines a continuous electrode. An electrode border surrounding the plurality of electrodes can be deposited on the first surface of the dielectric medium. Alternatively, the plurality of electrodes can define column-shaped electrodes, while the second electrode defines a plurality of row-shaped electrodes separated by etchings. The direction of orientation of each column-shaped electrode and the direction of orientation of each row-shaped electrode can be substantially perpendicular. A method of making a piezoelectric sensor is also provided. | 07-30-2009 |
| 20090162877 | Methods to Identify Protein Arginine Deiminase 4 Inhibitors - In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay. | 06-25-2009 |
| 20090142258 | PHYSIOCHEMICAL PATHWAY TO REVERSIBLE HYDROGEN STORAGE - In one embodiment of the present disclosure, a process for cyclic dehydrogenation and rehydrogenation of hydrogen storage materials is provided. The process includes liberating hydrogen from a hydrogen storage material comprising hydrogen atoms chemically bonded to one or more elements to form a dehydrogenated material and contacting the dehydrogenated material with a solvent in the presence of hydrogen gas such that the solvent forms a reversible complex with rehydrogenated product of the dehydrogenated material wherein the dehydrogenated material is rehydrogenated to form a solid material containing hydrogen atoms chemically bonded to one or more elements. | 06-04-2009 |
| 20090140144 | Tuning D* with Modified Thermal Detectors - Disclosed is apparatus and methodology for producing thermal detectors with spectral responsivities that mimic the absorptions of chemical analytes, and whose detector characteristics approach those of conventional broad-band thermal detectors. In an exemplary arrangement, the methodology provides for modification of a known Si-based thermal detector by adding a near-infrared dye absorbing film above a reflector deposited directly on the thermal detector element. The method is general to all types of thermal detectors that can be divided into separate absorber and thermal sensor components. | 06-04-2009 |
| 20090124579 | Systems and Methods For Determination of Compounds for Stimulation or Inhibition of Neocalcification - Disclosed are systems and methods as may be used for development of compounds that can be utilized for prevention of pathological calcification. Disclosed are functional models can represent in great detail the first steps in protein-membrane interaction leading to calcification. Disclosed compounds include those that interfere with pathologic calcification processes and thus may be used as part of a formulation or composition for preventing pathological calcifications. Modeling methods and systems can include in vitro and/or in silico dynamic molecular modeling of biological materials including representative mineralization models in conjunction with substances that can affect normal or pathogenic calcification processes. Disclosed models can examine interactions of biological components involved in calcification including calcium, inorganic phosphate, phosphatidylserine, and annexin-5 protein. | 05-14-2009 |
| 20090117257 | Catalysts for Fuel Cell Applications Using Electroless Deposition - In one embodiment, the present disclosure is directed to a process for electroless deposition of metal atoms on an electrode to form a core and shell structure. The process includes treating a carbon-containing support by contacting the carbon-containing support with a treatment. The carbon-containing support is impregnated with a core component metal to form at least one seed site on the carbon-containing support. A predetermined amount of shell component metal is deposited on the at least one seed site of the core component through electroless deposition by contacting the carbon-containing support with a metal salt and a reducing agent. The shell component forms at least one complete monolayer on the core component. The amount of the shell component deposited is predetermined by using the surface area of the core component. | 05-07-2009 |
| 20090089941 | Process for Creating Composite Materials to Produce Polymer Nanocomposite Films that Exhibit Improved Light Fastness Properties - The present invention relates to new methods of producing polymer composite materials. More specifically, the invention involves a process in which layered materials including clays and other inorganic materials are dispersed into polymer systems to create polymer nanocomposite films. The resulting films exhibit improved resistance to fading when compared to polymer films that lack the additional layered materials. | 04-09-2009 |
| 20090065738 | Electrocatalyst Support and Catalyst Supported Thereon - In one embodiment of the present disclosure an electrocatalyst support for a fuel cell is provided which includes a doped titania metal oxide. The dopant includes a valve metal. The doped titania metal oxide has a BET surface area of greater than 20 m | 03-12-2009 |
| 20090064425 | Polymer/Clay Nanocomposite Films with Improved Light Fastness Properties and Process for Producing Same - A colored polymeric material having improved light fastness is generally provided. The colored polymeric material generally comprises a polymer, a colorant, and natural nanoparticles. The colorant can be a dye, such as an acid dye. In one embodiment, the dye can be susceptible to degradation when exposed to light in the presence of oxygen, such as many azo dyes. The natural nanoparticles can include many natural clays. | 03-12-2009 |
| 20090050258 | DEVELOPMENT OF PEM FUEL CELL ELECTRODES USING PULSE ELECTRODEPOSITION - In one embodiment of the present disclosure a method for forming a PEM fuel cell electrode is provided. The method includes applying a hydrophilic wetting agent on an electrode surface. A catalyst layer is deposited on the wetted electrode surface by pulse electrodeposition, at least a portion of the catalyst penetrating the electrode surface. The electrode surface is heat treated. | 02-26-2009 |
| 20090048789 | Optimized Embedded Ultrasonics Structural Radar System With Piezoelectric Wafer Active Sensor Phased Arrays For In-Situ Wide-Area Damage Detection - The present subject matter is direct to apparatus and methodologies for performing omnidirectional (360°) damage detection in a thin-wall structure using a planar embedded piezoelectric wafer active sensors (PWAS) phased array. Virtual beamforming for the array is implemented through either a transmission process by selective energizing selected sensors or by a signal post-processing procedure. Sensors may be embedded in a thin-walled structure as planar or circular arrays to achieve omnidirectional damage detection. | 02-19-2009 |
| 20090029441 | BIONANOMATERIALS AND THEIR SYNTHESIS - The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed. | 01-29-2009 |
| 20090005461 | Use of Cannabidiol in the Treatment of Hepatitis - Cannabinoids are known to interact with CB1 and CB2 receptors expressed in the nervous and immune systems mediating a wide range of effects, including anti-inflammatory properties. However, cannabinoids that bind are also psychoactive thereby limiting their clinical use. Cannabidiol (CBD) is the most abundant nonpsychotropic plant cannabinoid but has not been studied as extensively as Δ | 01-01-2009 |
| 20090000956 | Production of Low Temperature Electrolytic Hydrogen - In one embodiment of the present disclosure, a process for electrochemical hydrogen production is provided. The process includes providing an electrochemical cell with an anode side including an anode, a cathode side including a cathode, and a membrane separating the anode side from the cathode side. The process further includes feeding molecules of at least one gaseous reactant to the anode, oxidizing one or more molecules of the gaseous reactant at the anode to produce a gas product and protons, passing the protons through the membrane to the cathode, and reducing the protons at the cathode to form hydrogen gas. | 01-01-2009 |
| 20080312855 | Systems and Methods for Power Hardware in the Loop Testing - A system for power hardware in the loop testing is described. The system includes a power system and a control system, the power system connected to a power converter of a device under test, the control system being in communication with the power system and the power converter. The control system determines the voltage input to the power system by utilizing the voltage output of the power converter, the voltage input determination being made by a control algorithm comprising | 12-18-2008 |
| 20080299666 | Novel Peptide-Based Borono-Lectin (PBL) Sensors - Peptide-based borono-lectin sensors, along with their synthesis and analysis and methods of use, are generally described. These sensors use peptides as a scaffold and introduce boronic acid moieties onto the peptide scaffold as the binding site for the targeted analyte (e.g., carbohydrates, glycans, etc.). The boronic acid moieties can be arranged on the protein scaffold in such a manner that a particularly targeted carbohydrate or glycoprotein will bond to the protein scaffold via the boronic acid functionality. Such bonding can indicated the presence or absence of that targeted analyte in the sample. | 12-04-2008 |
| 20080288184 | Automatic Signal Collection and Analysis for Piezoelectric Wafer Active Sensor - Disclosed is an apparatus and methodology for monitoring the health of a structure. Apparatus and methodologies are disclosed for applying a controlled signal sequence to an array of piezoelectric wafer active sensors and for analyzing echo returns from the applied signals to determine the health of the monitored structure. The applied signal may take on certain characteristics including being provided as a specially tailored chirp signal to compensate for non-linear characteristics of the monitored structure. | 11-20-2008 |
| 20080276687 | Thermal Selectivity Multivariate Optical Computing - A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample | 11-13-2008 |
| 20080273206 | Biomimetic Mineralization Method and System - Disclosed are methods and systems that can be quickly and efficiently utilized to examine the kinetics of a growth and development protocol in a controlled environment, for instance in vivo. Disclosed systems can include a synthetic mineralization complex that can nucleate calcium phosphate mineral deposition in a controlled environment, for instance a controlled environment that can mimic a natural environment in which biomineralization takes place. Also disclosed are non-contact optical methods as may be utilized to examine the kinetics of a developing solid phase. Disclosed systems and methods can be beneficially utilized in high throughput screening in the development of drugs for the treatment and prevention of pathological calcifications such as osteoarthritis and atherosclerosis. | 11-06-2008 |
| 20080266555 | Surface Enhanced Raman Spectroscopy Using Shaped Gold Nanoparticles - Surface enhanced Raman scattering (SERS) spectra of 4-mercaptobenzoic acid (4-MBA) self-assembled monolayers (SAMs) on gold substrates is presented for SAMs onto which gold nanoparticles of various shapes have been electrostatically immobilized. SERS spectra of 4-MBA SAMs are enhanced in the presence of immobilized gold nanocrystals by a factor of 10 | 10-30-2008 |
| 20080220506 | Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof - A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed. | 09-11-2008 |
| 20080217820 | Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof - A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed. | 09-11-2008 |
