University of Notre Dame du Lac Patent applications |
Patent application number | Title | Published |
20160038607 | NANOPARTICLE DRUG DELIVERY SYSTEMS - The invention provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes or micelles that contain one or more targeting peptides and/or anticancer drugs. In various embodiments, the components of the liposomes can include a) a phospholipid and optionally a lipid that is not a phospholipid; b) a pegylated lipid; c) a peptide-ethylene glycol (EG)-lipid conjugate wherein the peptide is a targeting ligand, and d) one or more drug-conjugated lipid, encapsulated drugs, or a combination thereof. The peptide-EG-lipid conjugate can be, for example, a compound of Formula (I) or Formula (II). The ethylene glycol (EG) segments of the peptide-EG-lipid conjugate can be, for example, EG6 to about EG36; and the EG segment can be conjugated to one or more lysine moieties. | 02-11-2016 |
20160031832 | QUINAZOLINONE ANTIBIOTICS - A new class of antibiotics effective against methicillin-resistant | 02-04-2016 |
20160023171 | MULTIBLOCK COPOLYMERS AND METHODS OF USE - The present invention relates to polymer compositions and their manufacture. Specifically, the invention relates to multiblock polymers and copolymers, their fabrication, modification and/or functionalization and use as membranes or films. | 01-28-2016 |
20160022834 | SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS - The invention provides for a method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand. | 01-28-2016 |
20150359762 | COMPOSITION AND METHOD FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CEREBRAL INJURY - Methods and compositions which include or include the administration of a hydrophobic drug, prodrug thereof, salt thereof, isoform thereof, or a combination thereof; cyclodextrin, prodrug thereof, salt thereof, or a combination thereof; polyethylene glycol, propylene glycol, or combination thereof; and optionally, a pharmaceutically acceptable carrier. | 12-17-2015 |
20150353572 | 1,3-BENZOTHIAZINONE, SULFOXIDE, AND SULFONE COMPOUNDS WITH ELECTROPHILIC SUBSTITUENT - A compound, having the following formula: | 12-10-2015 |
20150353571 | 1,3-BENZOTHIAZINONE SULFOXIDE AND SULFONE COMPOUNDS - A compound, having the following formula: | 12-10-2015 |
20150338348 | ULTRASENSITIVE SERS FLOW DETECTOR - The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection analysis, electrophoresis, and chromatography. A surface-enhanced Raman scattering (SERS) flow detector capable of ultrasensitive optical detection on the millisecond time scale has been developed. The device employs hydrodynamic focusing to improve SERS detection in a flow channel where a sheath flow confines analyte molecules eluted from a capillary over a planar SERS-active substrate. Increased analyte interactions with the SERS substrate significantly improve detection sensitivity. Raman experiments at different sheath flow rates showed increased sensitivity compared with the modeling predictions, indicating increased adsorption. At low analyte concentrations, rapid analyte desorption is observed, enabling repeated and high-throughput SERS detection. The flow detector offers substantial advantages over conventional SERS-based assays such as minimal sample volumes and high detection efficiency. | 11-26-2015 |
20150323495 | NON-AQUEOUS MICROCHIP ELECTROPHORESIS FOR CHARACTERIZATION OF LIPID BIOMARKERS - The invention provides devices and methods for the detection of hydrophobic biomarkers using 3D microchip capillary electrophoresis having a non-aqueous solvent system. Hydrophobic biomarkers can be placed in a microcapillary microchannel and electrokinetically injected into a second microcapillary microchannel through a nanocapillary array membrane. The hydrophobic biomarkers can then be separated and analyzed via mass spectrometry. Certain hydrophobic biomarkers can indicate a particular disease state. | 11-12-2015 |
20150321168 | CARBON NANOTUBE PONYTAILS - Carbon nanotubes (CNTs) are promising nanomaterials that have the potential to revolutionize water and waste treatment practices in the future. The direct use of unbounded CNTs, however, poses health risks to humans and ecosystems because they are difficult to separate from treated water. Here, we report the design and synthesis of carbon nanotube ponytails (CNPs) by integrating CNTs into micrometer-sized particles, which greatly improves the effectiveness of post-treatment separation using gravitational sedimentation, magnetic attraction, and membrane filtration. We further demonstrate that CNPs can effectively perform major treatment tasks, including adsorption, disinfection, and catalysis. Using model contaminants, such as methylene blue, | 11-12-2015 |
20150233877 | HIGH SENSITIVITY ELECTROSPRAY INTERFACE - The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray. | 08-20-2015 |
20150210975 | SYSTEMS AND METHODS FOR A CONTINUOUS CULTURE BIOSENSOR - A continuous culture system of genetically modified yeast or another biological organism detects contaminants in water through production of a fluorescent chemical continuously produced by the organism after it is contacted with a threshold concentration of a contaminant. Alternatively, a biological organism can detect toxins or extra nutrients by detecting a change in growth rate. Biological organisms can also be measured for mutagenic changes by comparing their genome with a control sample. A network of continuous culture systems may be used as part of a water contamination detection system for real-time water monitoring of contaminants from multiple sources simultaneously. | 07-30-2015 |
20150132354 | TISSUE SCAFFOLDS HAVING BONE GROWTH FACTORS - The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time. | 05-14-2015 |
20150093372 | GELATINASE INHIBITORS AND PRODRUGS - The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration. | 04-02-2015 |
20150047724 | FLUID MANIFOLD - A fluid manifold that consistently and reliably delivers fluids to one or more subject interfaces is provided. A branched pattern of bifurcated lumina carrying the fluid from a source to the outlets in each subject interface provides substantially equal amounts of fluid to each subject interface, thereby reducing the risk of over- or under-delivery of the fluid. A fluid-scavenging system is also included. A plurality of exhaust inlets in the interior of the subject interfaces is connected to a source of negative pressure through a channel and exhaust port to collect fluid before it can escape the subject interface, thereby reducing the risk of escaping fluid reaching the atmosphere. | 02-19-2015 |
20150038566 | REGULATION OF CHOLESTEROL HOMEOSTASIS - The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C. | 02-05-2015 |
20150031663 | PHTHALANILATE COMPOUNDS AND METHODS OF USE - The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo. | 01-29-2015 |
20140377160 | COMBUSTION SYNTHESIS OF GRAPHENE AND CARBONOUS NANOMATERIALS - The invention provides methods for the combustion synthesis (CS) of graphene by a novel exothermic self-sustained reaction between a refractory ceramic compound and a carbon-containing polymer under an inert gas atmosphere. The synthesis of graphene was confirmed by both transmission electron microscopy and Raman spectroscopy. The graphene produced has very low (<1 wt. %) oxygen content. Fluorocarbon gases released due to decomposition of the carbon-containing polymer in the combustion wave can reduce the ceramic to a gas and mesoporous carbon particles and graphene layers. The method does not require an external energy source because it occurs in a self-sustained synergetic manner after ignition. The methods are flexible in terms of tuning the synthesis conditions for desired products, and the method can be scaled to provide kilogram quantities. | 12-25-2014 |
20140349287 | Method and Apparatus for a Nanopipette Biosensor - A nanopipette biosensor capable of detecting a small concentration of target molecules within a sample solution using optical detection methods. The biosensor includes a nanopipette that connects a nanocolloid reservoir containing a nanocolloid solution and a sample reservoir containing a sample solution, where the nanopipette is tapered at the end connected to the sample reservoir. The nanocolloid solution includes nanoparticles functionalized with probes specific to miRNA of the target molecules and reporters. During the detection process, the nanocolloids nanoparticles aggregate such that plasmonic hotspots are formed. These hotspots magnify the reporter signals produced when the probes hybridize with target molecules. | 11-27-2014 |
20140338712 | MONO-METALLIC THERMOCOUPLES - Nanoscale thermocouples are made of a single material and are shape-engineered to contain one or more variations in their width along their length. The mono-metallic nanowire junctions resulting from the width variation(s) exploit a difference in the Seebeck coefficient that is present at these size scales. Such devices have a wide variety of uses and can be coupled with an antenna in order to serve as an infrared detector. | 11-20-2014 |
20140302996 | METHOD AND APPARATUS FOR ENHANCING VORTEX PINNING BY CONFORMAL CRYSTAL ARRAYS - Disclosed is a method and apparatus for strongly enhancing vortex pinning by conformal crystal arrays. The conformal crystal array is constructed by a conformal transformation of a hexagonal lattice, producing a non-uniform structure with a gradient where the local six-fold coordination of the pinning sites is preserved, and with an arching effect. The conformal pinning arrays produce significantly enhanced vortex pinning over a much wider range of field than that found for other vortex pinning geometries with an equivalent number of vortex pinning sites, such as random, square, and triangular. | 10-09-2014 |
20140273403 | LIGHT INDUCED NANOWIRE ASSEMBLY - The invention provides a method for assembling semiconducting nanowires, which method can include providing a mixture comprising a dielectric solvent and two or more semiconducting nanowires, wherein the semiconducting nanowires can be the same or different; exposing the mixture to an electrostatic charge under lighting conditions; and allowing macroscopic nanowire alignment to occur, wherein each nanowire is substantially oriented along the direction of the applied electric field. | 09-18-2014 |
20140256967 | CERIUM-CONTAINING ZEOLITES AND COKE REDUCTION METHODS - The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis. | 09-11-2014 |
20140161340 | ITERATIVE RECONSTRUCTION - An improved iterative reconstruction method to reconstruct a first image includes generating an imaging beam, receiving said imaging beam on a detector array, generating projection data based on said imaging beams received by said detector array, providing said projection data to an image reconstructor, enlarging one of a plurality of voxels and a plurality of detectors of the provided projection data, reconstructing portions of the first image with the plurality of enlarged voxels or detectors, and iteratively reconstructing the portions of the first image to create a reconstructed image. | 06-12-2014 |
20140120539 | Systems and Methods for Bead-Free Detection of Nucleotides - Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nucleic acid complex, without the use of nanobeads. In particular, the examples include providing a plurality of nucleic acid fragments and a species-specific oligonucleotide tags, measuring the size of the nucleic acid fragments and/or oligonucleotides to predetermine a standard distribution of the solution(s), introducing the oligonucleotides in a solution containing nucleic acid target materials and/or non-target materials, and hybridizing the oligonucleotides with the species-specific target material if present in the solution. The size of the nucleic acid complexes in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nucleic acid complexes after hybridization to the standard distribution. | 05-01-2014 |
20140113305 | EXOSOMES AND DIAGNOSTIC BIOMARKERS - The invention provides methods for the detection of | 04-24-2014 |
20140093449 | Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 04-03-2014 |
20140073993 | SYSTEMS AND METHODS FOR USING ISOLATED VOWEL SOUNDS FOR ASSESSMENT OF MILD TRAUMATIC BRAIN INJURY - A system and method of identifying an impaired brain functionality such as a mild traumatic brain injury using speech analysis. In one example, recordings are taken on a device from athletes participating in a boxing tournament following each match. In one instance, vowel sounds are isolated from the recordings and acoustic features are extracted and used to train several one-class machine learning algorithms in order to predict whether an athlete is concussed. | 03-13-2014 |
20140045722 | SYSTEMS AND METHODS FOR DETECTING AND QUANTIFYING A SEQUENCE OF NUCLEOTIDES - Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nanoparticle. In particular, the examples include functionalizing a plurality of nanoparticles to adapt the nanoparticles to hybridize with a species-specific target material, measuring the size of the functionalized nanoparticles to predetermine a standard distribution of non-hybridized nanoparticles, introducing the functionalized nanoparticles in a solution containing species-specific target materials and/or non-target materials, and hybridizing the functionalized nanoparticles with the species-specific target material if present in the solution. The size of the nanoparticles in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nanoparticles after hybridization to the standard distribution of non-hybridized nanoparticles. | 02-13-2014 |
20140022545 | METHODS AND APPARATUS TO OBTAIN SUSPENDED PARTICLE INFORMATION - Example methods and apparatus for obtaining suspended particle information are disclosed. A disclosed example method includes emitting light from a light source, dividing the light source into a first path and a second path, and directing the first path to a first container comprising a plurality of particles in a suspension material. The example method also includes directing the second path to a second container containing a suspension material devoid of particles, retrieving a first transmission value of the first path through the first container, and retrieving a second transmission value of the second path through the second container. The example method further includes directing the first and second paths to the second and first containers, respectively, retrieving a third transmission value of the first path a through the second container, retrieving a fourth transmission value of the second path through the first container, and calculating a ratio of the first and second transmission values to the third and fourth transmission values to determine an indication of transmissivity for a given wavelength. | 01-23-2014 |
20140006914 | SYSTEMS AND METHODS FOR COLLABORATIVE AND MULTIMEDIA-ENRICHED READING, TEACHING AND LEARNING | 01-02-2014 |
20130345048 | GLASS CATALYSTS FOR SOOT COMBUSTION AND METHODS OF MANUFACTURING THE SAME - A simplified method of manufacturing a catalyst for soot combustion includes the synthesis of a catalyst composition. A substrate is prepared for receipt of the composition and a sol solution is created utilizing the composition synthesized. Finally, a catalytic coating is applied to the substrate, through use of the sol solution. The catalyst composition may be any suitable composition including a K | 12-26-2013 |
20130342279 | METHODS AND APPARATUS FOR TERAHERTZ WAVE AMPLITUDE MODULATION - A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conductivity thereof, and the change in the optical conductivity of the layers of electrons causes an amplitude modulation of the transmitted electromagnetic wave passing through the capacitively coupled layers of electrons. | 12-26-2013 |
20130332115 | METHODS AND APPARATUS FOR ELECTROMAGNETIC SIGNAL POLARIMETRY SENSING - A system and method of identifying changes utilizing radio frequency polarization includes receiving a reflected and/or transmitted polarized radio frequency signal at a receiver, filtering, amplifying and conditioning the received signal, converting the received signal from an analog format to a digital format, processing the digital signal to elicit a polarization mode dispersion feature of the received signal, and comparing the polarization mode dispersion features to a known calibration to detect a change in a characteristic of the target object. | 12-12-2013 |
20130309699 | ANTIBODY PURIFICATION VIA AFFINITY CHROMATOGRAPHY - Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid. | 11-21-2013 |
20130281424 | ANTI-BACTERIAL SIDEROPHORE-AMINOPENICILLIN CONJUGATES - An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against | 10-24-2013 |
20130143841 | BENZOHETEROCYCLIC ANTI-BACTERIAL AGENTS - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 06-06-2013 |
20130068632 | METHODS AND APPARATUS FOR NANOMEMBRANE-BASED NUCLEIC ACID SENSING PLATFORM FOR PORTABLE DIAGNOSTICS - A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule. A voltammeter is provided to measure the electrical current or potential across the nanomembrane, and detect a change in the measured electrical current or potential to quantify the presence of the macromolecule | 03-21-2013 |
20130064878 | WOUND HEALING COMPOSITIONS AND METHODS - The invention provides a method of accelerating the healing process of a skin or subdermal wound. The method can include administering to a mammal afflicted with a skin or subdermal wound an effective amount of a gelatinase inhibitor, or a pharmaceutically acceptable salt thereof, wherein the gelatinase inhibitor is effective to accelerate the healing process of the skin wound. The method is particularly effective when the mammal is suffering from diabetes. The gelatinase inhibitor can be topically administered, for example, in the form of a cream, gel, lotion, ointment, salve, or solution. | 03-14-2013 |
20130052184 | GELATINASE INHIBITORS AND PRODRUGS - The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration. | 02-28-2013 |
20130034908 | ANALYTICAL DEVICES FOR DETECTION OF LOW-QUALITY PHARMACEUTICALS - An analytical device, in particular, a paper analytical device (PAD), for detection of at least two chemical components indicative of a low quality pharmaceutical product is provided. The analytical device can include a porous, hydrophilic medium, at least two assay regions associated with the porous, hydrophilic medium, at least one assay reagent or precursor thereof in the assay regions, and at least one electronically readable information zone. | 02-07-2013 |
20130000228 | FLOORING APPARATUS FOR REDUCING IMPACT ENERGY DURING A FALL - An apparatus including an impact surface and a plurality of spaced apart stiffening columns extending from an underside of the flooring plate. The columns remain substantially rigid up to a predetermined critical pressure and then buckle as the pressure increases. The columns are at least partially surrounded by a resilient underlayment. Deflection stops may extend from the flooring plate to prevent over-buckling and/or permanent deformation of the stiffening columns. In some examples, the deflections stops may assist the floor in providing a substantially rigid surface at very high pressures. | 01-03-2013 |
20120322076 | MICROCHAMBER ELECTROCHEMICAL CELL HAVING A NANOSLOT - A microchamber electrochemical cell and method of using the cell for performing quantitative analysis of various charged macromolecules is presented. The microchamber electrochemical cell includes a substrate, opposing electrodes and at least one nanoslot. The substrate is configured to define a pair of opposing fluid reservoirs. The pair of opposing electrodes are respectively positioned within the opposing fluid reservoirs. Each nanoslot is configured to fluidly connect the opposing fluid reservoirs together. The opposing fluid reservoirs of the microchamber electrochemical cell are fluidly connected to each other only through each nanoslot. Each nanoslot is physically restricted to less than 500 nanometers. One method includes the steps of coupling, filling, measuring, obtaining, performing and preparing. | 12-20-2012 |
20120296085 | CHEMILUMINESCENT DYES AND DYE-STAINED PARTICLES - Chemiluminescent compounds that can be activated by reaction with chemical or photochemical sources of singlet oxygen are provided. At certain temperatures, such as from approximately 15 to 60° C., the compounds slowly return to their deactivated state by emitting visible and/or infrared light that is observable with various types of light detectors. Suitable conjugates of these compounds, or small particles containing these compounds, may be used for chemiluminescence imaging and sensing technologies. In particular, embodiments provide optical molecular imaging using novel squaraine rotaxane endoperoxides (SREPs) and squaraine catenane endoperoxides (SCEPs), interlocked fluorescent and chemiluminescent dye molecules that have a squaraine chromophore encapsulated inside a macrocycle endoperoxide. The dyes may be stored at low temperature, such as below 0° C., but, upon warming above 15° C., such as to body temperature, they undergo a unimolecular cycloreversion reaction that releases singlet oxygen and emits visible or near-infrared light that can pass through living tissue. The chemiluminescent signal is detectable with inherently high contrast because there is negligible background emission. | 11-22-2012 |
20120289704 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents. | 11-15-2012 |
20120237965 | SYSTEMS AND METHODS FOR A CONTINUOUS CULTURE BIOSENSOR - A continuous culture system of genetically modified yeast or another biological organism detects contaminants in water through production of a fluorescent chemical continuously produced by the organism after it is contacted with a threshold concentration of a contaminant. Alternatively, a biological organism can detect toxins or extra nutrients by detecting a change in growth rate. Biological organisms can also be measured for mutagenic changes by comparing their genome with a control sample. A network of continuous culture systems may be used as part of a water contamination detection system for real-time water monitoring of contaminants from multiple sources simultaneously. | 09-20-2012 |
20120225425 | Cathepsin E as a Marker of Colon Cancer - Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are demonstrated to be detectable in the urine of animals having colorectal cancer, and a diagnostic/screening method for identifying and/or detecting colorectal cancer in an animal from a urine sample is provided. Specific tissue immunohistochemcial staining for catE (monomeric forms) in dysplastic tissue is also disclosed, and is shown to correlate with the level of dysplastic lesion severity. Hence, a method for identifying and determining the level of dysplastic lesion severity is provided. Cathepsin E mRNA transcription and expression levels are also demonstrated to be upregulated in dysplastic tissue, relative to non-dysplastic tissue. Hence, a method for transcriptionally profiling an animal to monitor the progression of colorectal disease is provided. | 09-06-2012 |
20120222557 | IONIC LIQUIDS COMPRISING HETERAROMATIC ANIONS - Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein. | 09-06-2012 |
20120220457 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2- a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds. | 08-30-2012 |
20120032227 | LOW VOLTAGE TUNNEL FIELD-EFFECT TRANSISTOR (TFET) AND METHOD OF MAKING SAME - A low voltage tunnel field effect transistor includes a p-n tunnel junction, a gate-dielectric, a gate, a source-contact, and a drain-contact. The p-n tunnel junction includes a depletion region interfacing together a source-layer and a drain-layer. The depletion region includes a source-tunneling-region of the source-layer and a drain-tunneling-region of the drain-layer. When no external electric field is imposed, the depletion region of the p-n tunnel junction has an internal electric field that substantially points towards the source-tunneling-region and the drain-tunneling-region. The gate-dielectric is interfaced directly onto the drain-tunneling-region such that the drain-tunneling-region is between the source-tunneling-region and the gate-dielectric. The gate is interfaced onto the gate-dielectric such that the gate is configured to impose an external electric field which is oriented substantially in parallel to the internal electric field of the depletion region. | 02-09-2012 |
20110237832 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES - Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available. | 09-29-2011 |
20110118459 | HIGH PERFORMANCE LUMINESCENT COMPOUNDS - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes. | 05-19-2011 |
20110086817 | ANTI-BACTERIAL AGENTS FROM BENZO[D]HETEROCYCLIC SCAFFOLDS FOR PREVENTION AND TREATMENT OF MULTIDRUG RESISTANT BACTERIA - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 04-14-2011 |
20110076305 | EXTRACELLULAR MATRIX MATERIALS AS VACCINE ADJUVANTS FOR DISEASES ASSOCIATED WITH INFECTIOUS PATHOGENS OR TOXINS - Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal. | 03-31-2011 |
20110071109 | HISTONE DEACETYLASE INHIBITORS AS THERAPEUTIC AGENTS FOR LYSOSOMAL STORAGE DISORDERS - Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described. | 03-24-2011 |
20110021574 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in a subject, such as using the disclosed heterocyclic anti-cancer agents. | 01-27-2011 |
20100331542 | PROBES FOR ANIONIC CELL SURFACE DETECTION - Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositions and preparations, particularly preparations suitable for use as laboratory/clinical reagents and diagnostic indicators, either alone or as part of a kit. An embodiment of the invention provides for a highly selective agent useful in the discernment and identification of dead or dying cells, such as apoptotic cells, in a relatively calcium-free environment. An embodiment of the invention provides a selective agent for the identification of bacteria in a mixed population of bacterial cells and nonbacterial cells. | 12-30-2010 |
20100261673 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME - Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of | 10-14-2010 |
20100233214 | Extracellular matrix cancer vaccine adjuvant - Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), trocar, or other solid or semi-solid preparation. The invention provides for enhanced tumor inhibition of 2-fold or greater, compared to vaccine preparations without the extracellular matrix material, or from 4- to 5-fold, compared to preparations without the adjuvant promoting extracellular materials. | 09-16-2010 |
20100202669 | IRIS RECOGNITION USING CONSISTENCY INFORMATION - Embodiments of the present invention include but are not limited to methods and systems for iris recognition. An iris recognition method may comprise comparing a plurality of images of an iris to determine at least one of one or more consistent features and one or more inconsistent features of the iris; and constructing an enrollment template for the iris based at least in part on the at least one of the one or more consistent features and the one or more inconsistent features. | 08-12-2010 |
20100136050 | Extracellular Matrix Materials as Vaccine Adjuvants for Diseases Associated with Infectious Pathogens or Toxins - Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogenicity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal. | 06-03-2010 |
20090252382 | SEGMENTATION OF IRIS IMAGES USING ACTIVE CONTOUR PROCESSING - Aspects of the present invention are generally directed to processing of an obtained iris image. An iris is image is segmented for use in a biometric recognition scheme. | 10-08-2009 |
20090114273 | NANOMATERIAL SCAFFOLDS FOR ELECTRON TRANSPORT - Embodiments of the present invention provide nanomaterial scaffolds for transporting electrons. There is provided a single wall carbon nanotube (SWCNT) architecture employed as a conducting scaffold in semiconductor based photoelectrochemical cells. SWCNT architecture provides a nanotube network to disperse nanoparticles and/or quantum dots, whether ordered or randomized. As a result, an increase in incident photon conversion to charge carrier conversion efficiency (IPCE) represents a beneficial role of SWCNT architecture as a conducting scaffold to facilitate charge collection and charge transport in nanostructured semiconductor films. Embodiments may be used for solar cells based on semiconductor quantum dots and nanostructures, solar hydrogen production, microcapacitors and storage batteries, solar-fuel cell hybrids, etc. | 05-07-2009 |