University of Maryland, College Park Patent applications |
Patent application number | Title | Published |
20160129530 | Transient Liquid Phase Sinter Pastes and Application and Processing Methods Relating Thereto - The present invention relates to transient liquid phase sinter pastes for electronic interconnects, and sinter paste application and processing methods. | 05-12-2016 |
20160038572 | Endolysins Active Against Staphylococcus Bacteria, Pharmaceutical Compositions, and Methods Relating Thereto - The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS. | 02-11-2016 |
20160018337 | Color Changing Polymer Films for Detecting Chemical and Biological Targets - A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte. | 01-21-2016 |
20150290356 | Solution Blow Spun Polymer Fibers, Polymer Blends Therefor and Methods of Use Thereof - Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive). | 10-15-2015 |
20150115488 | Microfluidic Liposome Synthesis, Purification and Active Drug Loading - Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels. | 04-30-2015 |
20150012273 | SYSTEMS AND METHODS FOR MULTIPLE PITCH TRACKING - An apparatus includes a function module, a strength module, and a filter module. The function module compares an input signal, which has a component, to a first delayed version of the input signal and a second delayed version of the input signal to produce a multi-dimensional model. The strength module calculates a strength of each extremum from a plurality of extrema of the multi-dimensional model based on a value of at least one opposite extremum of the multi-dimensional model. The strength module then identifies a first extremum from the plurality of extrema, which is associated with a pitch of the component of the input signal, that has the strength greater than the strength of the remaining extrema. The filter module extracts the pitch of the component from the input signal based on the strength of the first extremum. | 01-08-2015 |
20140356415 | COMPOSITIONS AND VACCINES COMPRISING VESICLES AND METHODS OF USING THE SAME - The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are useful to stimulate an antigen-specific immune response and, in some embodiments, a protective immune response in an animal after challenge to pathogens. The compositions of the disclosure are also useful for treatment and prevention of disease in a subject such as cancer. | 12-04-2014 |
20140342949 | Tube-in-a-Tube Electronic Sensors - The present invention is directed to tube-in-a-tube electronic materials and electronic chemical sensors comprising tube-in-a-tube configurations such as covalently functionalized double-walled carbon nanotubes. | 11-20-2014 |
20140328898 | Nano-Liposomal Formulations and Methods of Use - A method for transdermal drug delivery provides for the topical administration of liposome encapsulated nanoparticles. The encapsulated nanoparticles define a nearly monodisperse population of liposomes having an average diameter within a selected size range. Liposomal nanoparticle formulations and methods of treatment therewith are also provided. | 11-06-2014 |
20140314666 | TARGETED CARRIERS FOR DRUG DELIVERY ACROSS THE GASTROINTESTINAL EPITHELIUM - A system and method for transcellular transport of compositions containing agents (e.g., research, analytical, reporter or molecular probes, diagnostic and therapeutic agents, biologically active agents, research agents, analytical agents, imaging agents, monitoring agents, enzymes, proteins, peptides, nucleic acids, lipids, sugars, hormones, lipoproteins, chemicals, viruses, bacteria, cells, including modified cells, biosensors, markers, antibodies and/or ligands) across the gastrointestinal epithelial layer including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes an anti-ICAM antibody targeting moiety, specific for targeting ICAM-1. The system enables effective, versatile, and safe targeting and transport of agents. The system is useful in research applications, as well as in the context of translational science and clinical interventions. | 10-23-2014 |
20140302420 | Ceramic Anode Materials for Solid Oxide Fuel Cells - Novel anode materials including various compositions of vanadium-doped strontium titanate (SVT), and various compositions of vanadium- and sodium-doped strontium niobate (SNNV) for low- or intermediate-temperature solid oxide fuel cell (SOFCs). These materials offer high conductivity achievable at intermediate and low temperatures and can be used as the structural support of the SOFC anode and/or as the conductive phase of an anode. A method of making a low- or intermediate-temperature SOFC having an anode layer including SVT or SNNV is also provided. | 10-09-2014 |
20140290931 | High Temperature Solder For Downhole Components - A downhole tool conveyable within a wellbore extending into a subterranean formation, wherein the downhole tool comprises a first component, a second component, and a solder electrically and mechanically coupling the first and second components, wherein the solder comprises or consists of: from 0.001 to 1.0 weight % of copper; from 2.5 to 4.0 weight % of silver; from 0.01 to 0.25 weight % of manganese; and tin. | 10-02-2014 |
20140272665 | Ceramic Fuel Cell With Enhanced Flatness And Strength And Methods Of Making Same - Ceramic fuel cells having enhanced flatness and strength are disclosed. The fuel cell can include a half-cell having, in order, a patterned layer, an anode support layer and an electrolyte layer. Methods of making ceramic fuel cells are also provided. | 09-18-2014 |
20140221586 | Methods for Stereoselective Coordinative Chain Transfer Polymerization of Olefins - The present invention provides a method of producing a polyolefin composition comprising contacting a binuclear metallocene pre-catalyst and a co-catalyst, adding a excess of a metal alkyl, then adding a first olefin monomer. The method allows for the production of polyolefins with a highly stereoregular stereochemical micrsostructure through living coordination polymerization in which rapid reversible chain transfer between a racemic mixture of a chiral active transition metal propagating center and multiple equivalents of inert main group metal alkyl is competitive with chain-growth propagation at the active center. By virtue of the slower rate of chain-transfer relative to propagation that can be achieved with a binuclear catalyst relative to the corresponding mononuclear catalyst, the present invention provides a work-around solution to the intrinsic limitation on product volume imposed by a traditional living polymerization, as well as a work-around solution to the stereochemically random microstructure that is normally obtained as the result of rapid and reversible chain-transfer between two populations of chiral active propagating centers, of opposite absolute configuration, when a racemic mixture of the pre-catalyst is employed. In essence, the field of invention is defined as stereoselective living coordinative chain-transfer polymerization. | 08-07-2014 |
20140206480 | ELECTRONIC HOME PLATE FOR BASEBALL AND SOFTBALL GAMES AND METHOD FOR AUTOMATIC DETERMINATION OF PRESENCE, POSITION AND SPEED OF A BALL RELATIVE TO THE STRIKE ZONE - An electronic home plate providing assistance to an umpire in determination whether a pitch results in a “strike” or a “ball”. The electronic home plate is implemented with eye-safe LEDs producing light beams extending vertically. If a ball intersects the light beams, the light reflected from the ball is scattered and incident on photodetectors embedded in the home plate. A microcomputer embedded in the electronic home plate calculates the height of the ball crossing the light beams, and if the height falls between the top and bottom boundaries of a strike zone adjusted to the height of the batter, an indication system is activated to produce a “strike” signal. The microcomputer in the electronic home plate is further configured to calculate speed of the ball passing over the home plate, and the lateral position of the ball. | 07-24-2014 |
20140191438 | Microfluidic Devices and Methods of Fabrication - The present invention relates to microfluidic devices that comprise a 3-D microfluidic network of microchannels of arbitrary complexity and to a method for fabricating such devices. In particular, the invention relates to a method of forming microfluidic devices having 3-D microfluidic networks that contain open or closed loop microchannels using a single-step molding process without the need for layer-by-layer fabrication, and to the resultant microfluidic devices. The networks of such microfluidic devices may comprise one or more microchannel circuits which may be discrete or interconnected. | 07-10-2014 |
20140188070 | ADVANCED FUNCTIONAL BIOCOMPATIBLE FOAM USED AS A HEMOSTATIC AGENT FOR COMPRESSIBLE AND NON-COMPRESSIBLE ACUTE WOUNDS - A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood. | 07-03-2014 |
20140148398 | METHODS OF TREATING GIARDIASIS - Compounds useful for the treatment of giardiasis are described. | 05-29-2014 |
20140094529 | MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME - Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable. | 04-03-2014 |
20140073752 | Living Coordinative Chain Transfer Polymerization with Dynamic Counterion Exchange - Disclosed is a method of producing a polyolefin composition comprising contacting a metal alkyl and a first olefin monomer, then adding a first co-catalyst, a second co-catalyst, a pre-catalyst, and a second olefin monomer. The method allows for the production of a series of copolymers with tunable incorporation ratios of the first olefin monomer. The method also allows for the production of polyolefins of low molecular weights and narrow molecular weight distributions. | 03-13-2014 |
20140066752 | Methods and Systems for Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents - Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. | 03-06-2014 |
20140065602 | Human Exhaled Aerosol Droplet Biomarker System and Method - A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers. | 03-06-2014 |
20140058528 | Time Domain-Based Methods for Noninvasive Brain-Machine Interfaces - A noninvasive brain computer interface (BCI) system includes an electroencephalography (EEG) electrode array configured to acquire EEG signals generated by a subject. The subject observes movement of a stimulus. A computer is coupled to the EEG electrode array and configured to collected and process the acquired EEG signals. A decoding algorithm is used that analyzes low-frequency (delta band) brain waves in the time domain to continuously decode neural activity associated with the observed movement. | 02-27-2014 |
20140043618 | Coherence Gated Doppler Motion Sensor and Medical Applications - A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates motion in a target volume of a sample in a vicinity of the probe tips based on a Doppler shift of the scattered light. The volume depends on coherence distance determined by the bandwidth. In variations, the first and second tips are the same tip, a multimode fiber is included, the bandwidth is between 0.1% and 5% of a center wavelength, or the presentation device is a speaker, or some combination. | 02-13-2014 |
20130345273 | REVERSAL OF DRUG-INDUCED NEUROMUSCULAR BLOCK USING NOVEL MOLECULAR CONTAINERS - Provided are methods for reversing the effects of agents used for muscular immobilization and/or loss of consciousness and/or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and/or anesthetic agents such that the effects of the agent(s) are partially fully reversed. | 12-26-2013 |
20130337579 | Methods for Determining Protein Ligand Binding - Provided is a high-throughput differential radial capillary action of ligand assay (DRaCALA) that can be used to detect ligand binding to a protein. The assay is rapid, quantitative and allows detection of protein-ligand interactions for both purified proteins and proteins expressed in whole cells, which eliminates the need for protein purification. The method does not require a wash step, and can be performed without a drying step and without the aid of electrophoretic techniques. The method entails separating unbound ligand from bound ligand by placing a liquid composition that contains or is suspected of containing a protein and a detectably labeled ligand on a dry porous membrane to obtain a location on the membrane that contains the protein. Ligand that is bound to the protein does not migrate away from the location while unbound ligand radially migrates away from the location by capillary action, which separates unbound from bound ligand. The method includes determining whether a ligand binds to one or more proteins and whether a test composition contains a protein. | 12-19-2013 |
20130293884 | Nanoparticle array with tunable nanoparticle size and separation - The present invention is directed to self-assembled nanoparticle arrays, methods of making the nanoparticle arrays, and methods of using the nanoparticle arrays in spectroscopic methods for detecting targets of interest. The present invention is also directed to a fabrication method for surface-enhanced Raman scattering (SERS) substrates that possess a unique combination of three highly desirable attributes: (a) the SERS substrates can be tuned to match the laser wavelength of operation and maximize the enhancement factor for the particular Raman instrument and analyte in use; (b) the SERS substrates have a highly reproducible enhancement factor over macroscopic sampling areas; and (c) the fabrication method is achieved without resorting to expensive, slow nano-lithography tools. | 11-07-2013 |
20130273587 | SCREEN TO IDENTIFY AGENTS THAT CAN MODULATE HEME TRANSPORTER - Provided are compositions and methods related to heme transporters and high-throughput methods of identifying agents that can modulate heme transporters. An approach for identifying a modulator of a eukaryotic heme transporter involves adding a toxic heme analog and at least one test agent to a culture of cells, wherein the cells express a recombinant heterologous eukaryotic heme transporter. The cells are incubated with the toxic heme analog and the test agent for a period of time. A change in toxic effect of the toxic heme analog relative to a control is indicative that the test agent is a modulator of the eukaryotic heme transporter. Heme transporter agonists and antagonists can be identified. Also provided is a cell culture comprising a plurality of cells which express a recombinant heterologous eukaryotic heme transporter. The plurality of cells are divided into a plurality of reaction chambers, each of which may contain a test agent, and may further contain a toxic heme analog. | 10-17-2013 |
20130267408 | Porous Oxide Microparticles and Composites Thereof and Methods of Making and Using Same - Provided are substantially spherical, porous oxide microparticles having a plurality of substantially spherical voids, substantially spherical, porous oxide-organic polymer composite microparticles having a plurality of substantially spherical organic polymer domains. The microparticles can be made using a microdispersive suspension polymerization step to make microparticles having an organic polymer shell and a plurality of discrete substantially spherical organic nanoparticles. The microparticles can be used as polymerization catalyst supports. | 10-10-2013 |
20130218005 | MINIMALLY INVASIVE NEUROSURGICAL INTRACRANIAL ROBOT SYSTEM AND METHOD - Minimally invasive neurosurgical intracranial robot system is introduced to the operative site by a neurosurgeon through a narrow surgical corridor. The robot is passed through a cannula and is attached to the cannula by a latching mechanism. The robot has several links interconnected via revolute joints which are tendon-driven by tendons routed through channels formed in the walls of the links. The robot is teleoperatively guided by the neurosurgeon based on real-time images of the intracranial operative site and tracking information of the robot position. The robot body is equipped with a tracking system, tissue liquefacting end-effector, at as well as irrigation and suction tubes. Actuators for the tendon-driven mechanism are positioned at a distance from the imaging system to minimize distortion to the images. The tendon-actuated navigation of the robot permits an independent control of the revolute joints in the robot body. | 08-22-2013 |
20130197271 | DENDRIMERS AND METHODS OF PREPARING SAME THROUGH PROPORTIONATE BRANCHING - The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance. | 08-01-2013 |
20130190940 | OPTIMIZING AND CONTROLLING THE ENERGY CONSUMPTION OF A BUILDING - Described herein are methods and systems, including computer program products, for optimizing and controlling the energy consumption of a building. A first computing device generates a set of thermal response coefficients for the building based on energy characteristics of the building and weather data associated with the location of the building. The first computing device predicts an energy response of the building based on the set of thermal response coefficients and forecasted weather associated with the location of the building. The first computing device selects minimal energy requirements of the building based on an energy consumption cost associated with the building. The first computing device determines one or more temperature set points for the building based on the energy response and the minimal energy requirements. The first computing device transmits the one or more temperature set points to a thermostat of the building. | 07-25-2013 |
20130109900 | Scalable Production of Precision Hydrocarbons from Trialkylaluminum via Ternary Living Coordinative Chain Transfer Polymerization | 05-02-2013 |
20130107254 | Porous SERS Analytical Devices and Methods of Detecting a Target Analyte | 05-02-2013 |
20130095091 | METHODS OF REGULATING UPTAKE AND TRANSCELLULAR TRANSPORT OF LEUKOCYTES AND THERAPEUTICS - Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium are provided, based on the identification of CAM-mediated endocytosis and the sphingomyelin/ceramide pathway as active steps in transcellular TEM. Administration of regulators relating to the identified pathways, such as NHE1, sphingomyelinases, acid sphingomyelinase and ceramide, permit control and regulation of uptake and transcellular transport. Control and regulation of uptake and/or transcellular transport is applicable in strategies to modulate inflammation, provide controlled and/or targeted delivery of agents, control pathogenic invasion, recover action of an inhibited CAM-mediated uptake or transendothelial pathway, or provide uptake or transendothelial transport by targeting cell surface markers other than ICAM-1. | 04-18-2013 |
20130072669 | Covalently Functionalized Carbon Nanostructures and Methods for Their Separation - The present invention is directed to carbon nanostructures, e.g., carbon nanotubes, methods of covalently functionalizing carbon nanostructures, and methods of separating and isolating covalently functionalized carbon. In some embodiments, carbon nanotubes are reacted with alkylating agents to provide water soluble covalently functionalized carbon nanotubes. In other embodiments, carbon nanotubes are reacted with a thermally-responsive agent and exposed to light in order to separate carbon nanotubes of a specific chirality from a mixture of carbon nanotubes. | 03-21-2013 |
20130040656 | METHOD AND SYSTEM FOR DETERMINING RELATIVE DISPLACEMENT AND HEADING FOR NAVIGATION - A system and method for determining a location of a mobile object is provided. The system determines the location of the mobile object by determining distances between a plurality of sensors provided on a first and second movable parts of the mobile object. A stride length, heading, and separation distance between the first and second movable parts are computed based on the determined distances and the location of the mobile object is determined based on the computed stride length, heading, and separation distance. | 02-14-2013 |
20130017796 | SYSTEMS, METHODS, DEVICES, AND COMPUTER PROGRAM PRODUCTS FOR CONTROL AND PERFORMANCE PREDICTION IN WIRELESS NETWORKS - Systems, methods, devices, and computer program products are directed to mobility control and performance prediction in directional wireless networks. Network coverage and connectivity are optimized. Convex and non-convex network modeling is implemented to provide adaptive topology control and mobility control within the network, whereby communication links are retained, released, or reconfigured based on their communication role within the network architecture. Optionally or alternatively, network health is monitored, future network failure or degradation conditions are predicted, and the network reconfigures responsive to the predictions to avoid the failure or degradation conditions. | 01-17-2013 |
20120317142 | SYSTMEN AND METHOD FOR DATA MANAGEMENT IN LARGE DATA NETWORKS - A system and method for storing an input data network, in the form of graph is provided. The system includes a master node and a plurality of slave nodes. The master node is operable to receive the data network in the form of a graph, the graph including a plurality of vertices connected by edges; calculate a probability of co-retrieval for each of the plurality of vertices; and assign each of the plurality of vertices to one of the plurality of compute nodes based on the calculated probability of co-retrieval. Another method and system are provided for converting a dataset into a graph based index and storing the index on disk. Respective systems and methods of querying such data networks are also provided. | 12-13-2012 |
20120309047 | Color Changing Polymer Films for Detecting Chemical and Biological Targets - A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte. | 12-06-2012 |
20120294900 | Phosphorylated and Branched Dihydroxy-Pentane-Dione (DPD) Analogs as Quorum Sensing Inhibitors in Bacteria - Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms. | 11-22-2012 |
20120267605 | Methods for the Production of Nanoscale Heterostructures - The present invention is directed to a novel synthetic method for producing nanoscale heterostructures, and particularly nanoscale heterostructure particles, rods and sheets, that comprise a metal core and a monocrystalline semiconductor shell with substantial lattice mismatches between them. More specifically, the invention concerns the use of controlled soft acid-base coordination reactions between molecular complexes and colloidal nanostructures to drive the nanoscale monocrystalline growth of the semiconductor shell with a lattice structure incommensurate with that of the core. The invention also relates to more complex hybrid core-shell structures that exhibit azimuthal and radial nano-tailoring of structures. The invention is additionally directed to the use of such compositions in semiconductor devices. | 10-25-2012 |
20120263652 | TARGETED CARRIERS FOR DRUG DELIVERY ACROSS THE GASTROINTESTINAL EPITHELIUM - A system and method for transcellular transport of compositions containing agents (e.g., research, analytical, reporter or molecular probes, diagnostic and therapeutic agents, biologically active agents, research agents, analytical agents, imaging agents, monitoring agents, enzymes, proteins, peptides, nucleic acids, lipids, sugars, hormones, lipoproteins, chemicals, viruses, bacteria, cells, including modified cells, biosensors, markers, antibodies and/or ligands) across the gastrointestinal epithelial layer including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes an anti-ICAM antibody targeting moiety, specific for targeting ICAM-1. The system enables effective, versatile, and safe targeting and transport of agents. The system is useful in research applications, as well as in the context of translational science and clinical interventions. | 10-18-2012 |
20120122208 | Tubular Bioreactor System for Use in Bone and Cartilage Tissue Engineering - A bioreactor system includes a growth chamber having an inlet, an outlet, and defining a cavity, a media reservoir is in fluid communication with the inlet, and a pump configured to perfuse a media from the reservoir into the inlet and through the growth chamber. A plurality of discrete scaffold members is packed within the growth cavity. Spaces between adjacent scaffold members define pores. The media is movable around the scaffold members and through the pores via the pump. | 05-17-2012 |
20120119623 | LEAD-FREE PIEZOCERAMIC MATERIALS - The present invention relates to lead-free piezoelectric ceramic materials comprising crystalline (and preferably perovskite crystalline) structures of the formula Bi | 05-17-2012 |
20120119117 | Remote Nanoscale Photochemistry Using Guided Emission in Nanowires - A method of fabricating a nanodevice includes providing a nanowire having a first portion and a second portion. The nanowire has a polymer coating. A nanostructure is provided that is proximate to the second portion of the nanowire. Solely the first portion of the nanowire is irradiated with near-infrared radiation, thereby exciting the first portion to generate ultraviolet radiation. The generated ultraviolet radiation is guided from the first portion along the nanowire toward the second portion, so that a region of the polymer coating on the second portion is polymerized and bonds the nanostructure to the nanowire. | 05-17-2012 |
20120112121 | EMULSIONS OF HEAT TRANSFER FLUIDS INCLUDING NANODROPLETS TO ENHANCE THERMAL CONDUCTIVITIES OF THE FLUIDS - A heat transfer fluid emulsion includes a heat transfer fluid, and liquid droplets dispersed within the heat transfer fluid, where the liquid droplets are substantially immiscible with respect to the heat transfer fluid and have dimensions that are no greater than about 100 nanometers. In addition, the thermal conductivity of the heat transfer fluid emulsion is greater than the thermal conductivity of the heat transfer fluid. | 05-10-2012 |
20120103822 | ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS - Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling. | 05-03-2012 |
20120076730 | PEPTIDES FOR TRANSPORT OF THERAPEUTICS AND THEIR CARRIERS IN MOUSE MODELS AND HUMANS - A system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids, lipoproteins, sugars, hormones, vitamins, nucleic acids, viruses, bacteria, and/or cells) including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes a targeting moiety of one of peptides γ3, 2γ3, 3γ3, A1, B7, B8, B9, B1O, and D6, specific for targeting ICAM-I. The system enables effective, versatile, and safe targeting and transport of agents. The system is useful in research applications, as well as in the context of translational science and clinical interventions. | 03-29-2012 |
20120009242 | BLOOD COAGULATION INDUCING POLYMER HYDROGEL - The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated. | 01-12-2012 |
20120004518 | TECHNIQUES FOR COMPENSATING MOVEMENT OF A TREATMENT TARGET IN A PATIENT - One embodiment includes a method of predicting a position of a target site inside a body using surrogates is provided. The method includes transforming surrogate measurements and target positions into different representations by applying an operator, establishing a special relationship between the transformed surrogate measurements and the transformed target positions, and continuously predicting the target position from the transformed surrogate measurements and the established special relationship. | 01-05-2012 |
20110318771 | DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS - Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more | 12-29-2011 |
20110217785 | CHITOSAN-COATED WIRES FOR BIOSENSING - A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electro-depositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like. | 09-08-2011 |
20110195860 | FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAME - Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis. | 08-11-2011 |
20110191102 | SYSTEMS AND METHODS FOR SPEECH EXTRACTION - In some embodiments, a processor-readable medium stores code representing instructions to cause a processor to receive an input signal having a first component and a second component. An estimate of the first component of the input signal is calculated based on an estimate of a pitch of the first component of the input signal. An estimate of the input signal is calculated based on the estimate of the first component of the input signal and an estimate of the second component of the input signal. The estimate of the first component of the input signal is modified based on a scaling function to produce a reconstructed first component of the input signal. The scaling function is a function of at least one of the input signal, the estimate of the first component of the input signal, the estimate of the second component of the input signal, or a residual signal. | 08-04-2011 |
20110183140 | Method for Polymer Coating and Functionalization of Metal Nanorods - The present invention relates to polymers and their use in coating metal nanorods (especially gold nanorods), and to the coated nanorods compositions. In particular, the invention relates to a process for forming cetyltrimethylammonium bromide (CTAB)-coated gold nanorods and to such coated nanorods that additionally comprise an external cross-linked polymer coating. | 07-28-2011 |
20110085472 | Novel topology selection and broadcast method for rule-based link state routing - An apparatus and method are provided for optimizing the link-state information that is to be broadcast in a routing domain of a communication network for QoS rule-based link-state routing. The routers include any device capable of implementing the routing primitives. The apparatus and method involve pruning the link-state information using local neighborhood information that has been discovered. The local link-state is pruned so that the QoS optimal paths are preserved for link-state routing. Pruning of the potential optimal paths is carried out to minimize the information broadcast to the intra domain routers in an autonomous system/routing domain. The apparatus and method also involve broadcasting the selected link-state information. | 04-14-2011 |
20110081677 | Active Microfluidic Membranes - The present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidic network. More specifically, the invention relates to devices exhibiting (and methods of) positioning (i.e., erecting, modifying or removing a membrane matrix in situ in a microchannel of a microfluidic network of a microfluidic device. In one embodiment, the membrane comprises a single type of matrix constituent, such as chitosan, alginate, etc. Alternatively, the membrane may be composed of two or more matrix constituents, which may be integrated into one another or layered adjacent to one another. | 04-07-2011 |
20110054237 | Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets - Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. | 03-03-2011 |
20110008869 | ENGINEERED PROTEASES FOR AFFINITY PURIFICATION AND PROCESSING OF FUSION PROTEINS - The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention is fused to a second protein to form a protease prodomain fusion protein. The presence of a protease prodomain protein in a fusion protein allows for easy and selective purification of the second protein by incubation with the corresponding protease. | 01-13-2011 |
20100280286 | Process For The Preparation of Beta and Alpha Cryptoxanthin - The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph | 11-04-2010 |
20100272256 | Method and Implementation for Information Exchange Using Markov Models - The replacement of secret keys is a central problem in key management. Typical solutions exchange handshaking messages, involve complex computations, or require the cooperation of trusted third parties. Disclosed herein is a key replacement method that exploits the randomness of Markov models to efficiently provide fresh keys to users. Unlike other methods, the proposed method removes the need for extra communications, intensive computation, or third parties. It is demonstrated that the proposed method has perfect forward secrecy as well as resistance to known-key attacks. | 10-28-2010 |
20100266897 | High-Powered Electrochemical Energy Storage Devices and Methods for Their Fabrication - The present invention relates to electrochemical storage devices, such as supercapacitors, batteries, etc., and more particularly to such devices that comprise an electrochemically active coaxial nanowire. The invention particularly concerns such devices in which the coaxial nanowire comprises an inner core of a transition metal oxide and an axially surrounding outer shell composed of an electroconductive organic polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT). The invention particularly relates to a facile method for achieving the self-assembly of such coaxial nanowires. | 10-21-2010 |
20100255383 | Polymer Solid Electrolyte for Flexible Batteries - A flexible polymer solid electrolyte material useful in battery technology is described. The flexible solid electrolyte comprises a first block that has the ability to solvate alkali metal salts. The flexible solid electrolyte comprises a second block that has the ability to incorporate lithium ions within microphase separated spherical domains, wherein the lithium ions are from a secondary lithium source. The flexible solid electrolyte further comprises a second lithium salt. | 10-07-2010 |
20100096043 | High Temperature Solder Materials - A solder material is formed utilizing a transient liquid phase sintering process, where a precursor material is first formed. The precursor material comprises a plurality of metal particles including a first metal having a first melting point temperature and a second metal having a second melting point temperature, the first melting point temperature being greater than the second melting point temperature. The precursor material is heated to a process temperature (T | 04-22-2010 |
20090209703 | Methods for Modulated Degenerative Transfer Living Polymerization and Isotactic-Atactic Stereoblock and Stereogradient Poly(Olefins) Thereby - Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures. | 08-20-2009 |
20090093638 | Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions - The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers. | 04-09-2009 |
20080277631 | Electrically Conductive Metal Impregnated Elastomer Materials and Methods of Forming Electrically Conductive Metal Impregnated Elastomer Materials - An electrically conductive, compliant elastomer material that is impregnated with a metal is formed by combining a metal salt with an elastomer precursor material to form a metal salt/precursor mixture, curing the metal salt/precursor mixture to form an elastomer impregnated with metal salt, and treating the elastomer impregnated with metal salt with a chemical reducing composition so as to convert at least a portion of the metal salt impregnated within the elastomer to a metal. The elastomer can be subjected to a suitable solvent that swells the elastomer during the chemical reduction of the metal salt to metal, which enhances the mechanical and electrical properties of the resultant metal impregnated elastomer material. | 11-13-2008 |
20080241185 | IMPRINTED POLYMERIC MATERIALS FOR BINDING VARIOUS TARGETS SUCH AS VIRUSES - Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (e.g., viruses or bacteria) or biologic macromolecules (e.g., proteins or DNA). The imprinted polymeric material may be formed by template-directed synthesis using monomer units that interact with the template article. The monomer units are used to form a polymer matrix around the template article. Subsequently, the template article is removed from the polymer matrix. Also disclosed are imprinted polymeric materials comprising a cross-linked polymer matrix, which comprises a polyampholyte polymer. The polymer matrix has a binding cavity capable of selectively binding to a template article. Also disclosed are various uses for such imprinted polymeric materials. | 10-02-2008 |
20080212737 | Techniques For Compensating Movement of a Treatment Target in a Patient - Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patient is measured to produce real-time measurement data. Measuring the state is non-invasive; and the measured state is a correlated surrogate for position of the target site. Compensating movement data is determined based on the real-time measurement data to cause the target site to maintain a particular spatial relationship with the treatment delivery device. Either the treatment delivery device, or the support structure, or both, are moved based on the compensating movement data. When the delivery device alone is moved, the correlation between measured state and target site is based on partial least squares applied to pre-treatment measurements of both. | 09-04-2008 |