UNIVERSITY OF KANSAS Patent applications |
Patent application number | Title | Published |
20160040288 | APPARATUS FOR IN SITU DEPOSITION OF MULTILAYER STRUCTURES VIA ATOMIC LAYER DEPOSITION AND ULTRA-HIGH VACUUM PHYSICAL OR CHEMICAL VAPOR DEPOSITION - An apparatus for in situ fabrication of multilayer heterostructures is provided comprising a first vacuum chamber adapted for atomic layer deposition and comprising a first stage docking assembly configured to dock a detachable stage configured to support a substrate; a second vacuum chamber adapted for ultra-high vacuum physical or chemical vapor deposition and comprising a second stage docking assembly configured to dock the detachable stage; a load lock vacuum chamber between the first and second vacuum chambers and comprising a third stage docking assembly configured to dock the detachable stage, the load lock vacuum chamber coupled to the first vacuum chamber via a first shared valve and coupled to the second vacuum chamber via a second shared valve; and a substrate transport vacuum chamber comprising a substrate transfer device, the substrate transfer device configured to detachably couple to the detachable stage and to transfer the substrate supported by the detachable stage in situ between the first vacuum chamber, the second vacuum chamber and the load lock vacuum chamber. | 02-11-2016 |
20160030484 | MAMMALIAN PLURIPOTENT STEM CELLS, METHODS FOR THEIR PRODUCTION, AND USES THEREOF - The disclosure relates to nerve derived adult pluripotent stem cells characterized by expression of Oct4, Sox2, c-Myc, and Klf4, methods for obtaining them, and their use. | 02-04-2016 |
20150329200 | RADAR ENERGY ABSORBING DEFORMABLE LOW DRAG VORTEX GENERATOR - A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface features while reducing radar returns from structural details. Vortex generators (VGs) are typically used to reattach or smooth gross flowfields over aircraft surfaces. By doing so, an airfoil or wing can maintain attached flow at higher angles of attack and/or higher lift coefficients than one without the VGs. These devices are also used to reattach and/or smooth flows that encounter crossflow-induced instabilities and/or adverse pressure gradients on the upper surfaces of wings or near aircraft boattails. Other uses include reduction of buffet, vibration, flutter, cavity resonance or general bluff-body pressure drag reduction. Although conventional rigid VGs do generate vortical aerodynamic structures, two major problems are often experienced: i.) the inability to conform to curved surfaces, ii.) the generation of radar cross-section spikes produced by the VGs themselves. | 11-19-2015 |
20150231397 | METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION - Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels. | 08-20-2015 |
20150191442 | ALKYLENE EPOXIDATION WITH MESOPOROUS CATALYSTS - A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible solvent to form an alkylene oxide. The insoluble oxidation catalyst comprises a metal, preferably selected from the group consisting of tungsten, cerium, and niobium. The metal is directly incorporated within a solid mesoporous silicate support, such as one selected from the group consisting of KIT-5, KIT-6, and TUD-1. | 07-09-2015 |
20150136149 | BARRIER SYSTEM TO REDUCE THE RATE OF LINE-RELATED INFECTIONS - A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percuteneous incision. Such a barrier system can include: a barrier device having a skin-contacting surface and a catheter-receiving surface; and an adhesive composition configured for adhering to skin, the barrier device, and/or the catheter so as to form a barrier at or adjacent to an incision in the skin where the catheter is percutaneously inserted through the skin. The barrier device can include a conduit configured to receive the catheter. Alternatively, the barrier device can include a groove in a base surface that is configured to receive the catheter. A system that includes a medical device, the barrier device, and adhesive can also be provided. | 05-21-2015 |
20150122320 | Plasmonic Graphene and Method of Making the Same - Plasmonic graphene is fabricated using thermally assisted self-assembly of plasmonic nanostructure on graphene. Silver nanostructures were deposited on graphene as an example. | 05-07-2015 |
20150065463 | PHOSPHONATE DERIVATIVES AND METHODS OF USE THEREOF IN THE TREATMENT OF ALZHEIMER'S DISEASE - Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided. | 03-05-2015 |
20150050309 | VACCINE - The present invention relates, in-general, to Human immunodeficiency virus (HIV), and in particular to a carbohydrate-based vaccine for HIV and to methods of making and using same. | 02-19-2015 |
20150031571 | CHEMILUMINESCENT NANOPARTICLES AND USES THEREOF - Gold nanoparticles having luminol covalently linked thereto and optionally functionalized with an oligonucleotide and bacterial or viral detection assays. In one aspect, the detection system for detecting an analyte in a sample comprises a light-shielding container having a fiberoptic cable for transmitting light generated within the light-shielding container to a photodetector; a plurality of functionalized nanoparticles deposited in solid form on or within a support, such that the support is located within the light-shielding container; wherein the functionalized nanoparticles comprise nanoparticles covalently attached to one or more chemiluminescent moieties; and a reagent system which causes the chemiluminescent moieties to produce light in the presence of the reagent system and the analyte in the sample. | 01-29-2015 |
20150024300 | HYDROPHOBIZED GAS DIFFUSION LAYERS AND METHOD OF MAKING THE SAME - A gas diffusion layer having a first major surface and a second major surface which is positioned opposite to said first major surface and an interior between said first and second major surfaces is formed. The gas diffusion layer comprises a porous carbon substrate which is directly fluorinated in the interior and is substantially free of fluorination on at least one of the first major surfaces or the second major surfaces, and preferably both surfaces. The gas diffusion layer may be formed using protective sandwich process during direct fluorination or by physically or chemically removing the C—F atomic layer at the major surfaces, for example by physical plasma etching or chemical reactive ion etching. | 01-22-2015 |
20140335555 | AUTOMATED VITRIFICATION DEVICE - The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require little if any operator intervention or sample handling, thereby reducing contamination, improving success rates and increasing efficiency. Also provided are methods of vitrifying a biological sample, suitably using the disclosed devices. | 11-13-2014 |
20140274386 | PEER-SCORED COMMUNICATION IN ONLINE ENVIRONMENTS - Systems and methods for peer-scored dialogue are provided. Meaningful communications are fostered by enabling students or players of an online game to affect the score of other players by scoring the communications of other players. | 09-18-2014 |
20140245844 | SIMPLIFIED SPINE TESTING DEVICE - A sample testing device includes a motor, a gear reducer, and an output shaft coupled for rotation by the motor via the gear reducer. The sample testing device further includes a first device adapted to enable the output shaft to move linearly in a first direction substantially parallel with an axis of the output shaft and a second device coupled to the first device for enabling the output shaft to move linearly in a second direction substantially perpendicular to the first direction. The sample testing can further include a third device coupled to the first and second devices for enabling the output shaft to translate linearly in a third direction substantially perpendicular to the first and second directions. | 09-04-2014 |
20140243333 | SYNTHESIS OF FUNCTIONALIZED OCTAHYDRO-ISOQUINOLIN-1-ONE-8-CARBOXYLIC ESTERS AND ANALOGS, AND THERAPEUTIC METHODS - A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject. | 08-28-2014 |
20140238702 | LOW PH CROSSLINKING OF POLYMERS - The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. Methods of making and using such polymers are also provided. | 08-28-2014 |
20140221491 | In Vivo Method for Treating, Inhibiting, and/or Prophylaxis of Cancer, such as Pancreatic Cancer - An in vivo method of inhibiting tumor growth, specifically pancreatic cancer, includes administering to a subject in need thereof an effective amount of a compound, composition, and/or a pharmaceutical formulation including crocetinic acid. | 08-07-2014 |
20140209305 | DELAYED GELLING AGENTS - The disclosure is directed to polyelectrolyte complex nanoparticles that can be used to deliver agents deep into hydrocarbon reservoirs. Methods of making and using said polyelectrolyte complex nanoparticles are also provided. | 07-31-2014 |
20140196894 | FLUORESCENT TAGS FOR DETECTION OF SWELLABLE POLYMERS - The invention is directed to stable crosslinked swellable fluorescently tagged polymeric microparticles, methods for making same, and their various uses. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable pH of the target zone cause degradation of the labile crosslinker and the microparticles expand. The swelled polymer diverts water to lower permeability regions and improves oil recovery. The tags allow monitoring of the presence and concentration of the tagged microparticles and ultimately allow evaluation of the performance of such treatments. Detection of polymeric microparticles in producing wells can be instructive for teaching about the character and extent of thief zones in the subsurface. Better knowledge of the reservoir flow will enable improved application of the gel treatments, improved oil recovery, and allow improved forecasting using simulation modeling. | 07-17-2014 |
20140162912 | SWELLABLE POLYMER WITH CATIONIC SITES - The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising expandable polymeric particles having cationic sites as well as labile crosslinkers and stable crosslinkers, said particle mixed with a fluid. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into a target zones in the reservoirs and when the heat and/or a suitable pH in the reservoir cause degradation of the labile crosslinker and when the particle expands, the cationic sites in the polymer adsorb to negative sites of the rock in the formation, thus diverting water to lower permeability regions and improving oil recovery. However, many other uses are possible. | 06-12-2014 |
20140144628 | CROSSLINKING OF SWELLABLE POLYMER WITH PEI - The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and medical arts, gel electrophoresis, packaging, agriculture, the cable industry, information technology, in the food industry, papermaking, use as flocculation aids, and the like. More particularly, the invention relates to a composition comprising expandable polymeric microparticles having labile crosslinkers and stable crosslinkers, said microparticle mixed with a fluid and an unreacted tertiary crosslinker comprising PEI or other polyamine based tertiary crosslinker that is capable of further crosslinking the microparticle on degradation of the labile crosslinker and swelling of the particle, so as to form a stable gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric microparticles are injected into a well and when the heat and/or pH of the well cause degradation of the labile crosslinker and when the microparticle expands, the tertiary crosslinker crosslinks the polymer to form a stable gel, thus diverting water to lower permeability regions and improving oil recovery. | 05-29-2014 |
20140135484 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 05-15-2014 |
20140131043 | SWELLABLE POLYMER WITH ANIONIC SITES - The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable polymeric particles having anionic sites and labile crosslinkers and stable crosslinkers, said particle mixed with a fluid and a cationic crosslinker that is capable of further crosslinking the particle on degradation of the labile crosslinker and exposure of the anionic sites so as to form a gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable pH of the target zone cause degradation of the labile crosslinker and the particle expands, the cationic crosslinker crosslinks the polymer to form a gel, thus diverting water to lower permeability regions and improving oil recovery. | 05-15-2014 |
20140058593 | LOW-ALTITUDE ALTIMETER AND METHOD - A low-altitude altimeter ( | 02-27-2014 |
20140045851 | MORPHOLINES AS SELECTIVE INHIBITORS OF CYTOCHROME P450 2A13 - A method of inhibiting formation of cancerous metabolites, of inhibiting cytochrome P450 2A13 from forming carcinogen metabolites, and/or inhibiting formation of cancerous lung cells in a subject can include: providing a morpholine compound that selectively interacts with cytochrome P450 2A13 over cytochrome P450 2A6; administering a therapeutically effective amount of the morpholine compound or derivative to the subject. The morpholine compound or derivative can be substantially more selective for interacting with the cytochrome P450 2A13 over the cytochrome P450 2A6. The morpholine compound or derivative can also be substantially non-interactive with other physiological components. The morpholine compound or derivative can include a structure that selectively interacts with cytochrome P450 2A13 over cytochrome P450 2A6, such as Compounds 1-34 of Formulas A-D. | 02-13-2014 |
20140037626 | Metal Abstraction Peptide With Release of Metal - Compositions comprising peptides that are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed. Such compositions can be used for binding and releasing a metal in a variety of contexts and environments, such as the treatment of cancer. | 02-06-2014 |
20130341281 | Surface Modified Ceramic Filter - A porous ceramic filter having one or more coatings of elemental or compounds of iron, manganese, aluminum, titanium, or mixtures thereof deposited on the surface of the pores. | 12-26-2013 |
20130331018 | Laboratory Fume Hood System Having Recessed Heat Exchanger System - A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a primary fluid loop containing chilled fluid and a secondary fluid loop containing a cooling fluid which is in thermal communication the laboratory device. The primary fluid loop is located behind the fume hood wall and not in the interior work area. | 12-12-2013 |
20130330314 | Metal Abstraction Peptide With Superoxide Dismutase Activity - Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various embodiments, peptides are used for antioxidant activity, anti-inflammatory activity, anti-pain therapy, as chemical reagents, and/or as superoxide dismutase mimics. | 12-12-2013 |
20130296190 | PREDICTION OF SPONTANEOUS PRETERM BIRTH BY MEASURING CELL FREE NUCLEIC ACIDS IN MATERNAL BLOOD - A nucleic acid normalization kit can include a nucleic acid having a normalization sequence including or complementary to one or more of SEQ ID NOs: 1-4 and 301-303 or unique segment thereof, the nucleic acid being present in an amount sufficient for use in a nucleic acid normalization protocol. The normalization kit can be used in a method of identifying a pregnancy normalization nucleic acid sequence. A nucleic acid diagnostic kit for diagnosing susceptibility to preterm birth (PTB) can include a nucleic acid having a CFP RNA PTB biomarker sequence including or complementary to one or more of SEQ ID NOs: 5-300 or unique segment thereof, the nucleic acid being present in an amount sufficient for use in a nucleic acid diagnostic protocol for diagnosing susceptibility to PTB. The diagnostic kit can be used in a method for predicting susceptibility of a pregnant woman to preterm birth (PTB). | 11-07-2013 |
20130240781 | Ozonolysis Reactions in Liquid CO2 and CO2-Expanded Solvents - A method for increasing ozone concentration in a liquid can include: providing a gas having ozone; introducing the ozone-containing gas into a liquid, wherein the liquid and ozone combination has a temperature between about 0.8 and about 1.5 times the critical temperature of ozone; and increasing isothermally, the pressure of the ozone-containing gas above the liquid to about 0.3 to about 5 times the critical pressure of ozone so as to increase the ozone concentration in the liquid. The temperature is expressed in absolute units (Kelvin or Rankin). The method can be used for removing ozone from a gas or for purifying ozone. The liquid having a high ozone concentration can be used for ozonolysis of a substrate. | 09-19-2013 |
20130218121 | MEDICATION ACCESS DEVICE FOR PREVENTION OF MEDICATION RESERVOIR CONTAMINATION - A safety-engineered, one-time use, syringe adaptor-connector system restricts access to medical vials and intravenous bags (e.g., common reservoirs) using a valve and providing a barrier to inserting a needle in the reservoir. | 08-22-2013 |
20130189519 | Drug and Imaging Agent Delivery Compositions and Methods - A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820. | 07-25-2013 |
20130183327 | COMPOSITIONS INCLUDING I-DOMAIN ANTIGEN CONJUGATE COMPOUNDS AND METHODS FOR TREATMENT OF AUTOIMMUNE DISORDERS - The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune disorders in a subject. The present disclosure provides compounds including a modified I-domain peptide having two or more modified lysine residues and two or more signal 1 moieities conjugated to the modified lysine residues of the I-domain peptide and methods of using an making the compounds. | 07-18-2013 |
20130150330 | DECOQUINATE PRODRUGS - A compound can include a structure having decoquinate coupled to a prodrug moiety, or derivative or isomer or pharmaceutically acceptable salt thereof. The compound can be a decoquinate prodrug. The decoquinate prodrug can have a structure of any of the formulae described herein. The decoquinate prodrug can be synthesized in any manner, such as a synthetic method that includes Scheme 1A or Scheme 1B and Schemes 2, 3, and/or 4. The decoquinate prodrug can be prepared into a pharmaceutical composition with a pharmaceutically acceptable carrier, such as an aqueous composition. The decoquinate prodrug can be used for inhibiting or treating a parasitic infection, such as a malarial infection or a coccidian infection. | 06-13-2013 |
20130123149 | Polyelectrolyte Complexes for Oil and Gas Applications - A polyelectrolyte complex for the controlled release of an oil and gas field chemical selected from the group consisting of (a) a gel-forming or cross-linking agent, (b) a scale inhibitor, (c) a corrosion inhibitor, (d) an inhibitor of asphaltene or wax deposition, (e) a hydrogen sulfide scavenger, (f) a hydrate inhibitor, (g) a breaking agent, and a surfactant. | 05-16-2013 |
20130109684 | GRP94 INHIBITORS | 05-02-2013 |
20130108523 | TRAY FOR TISSUE BIOPSY SAMPLES, METHODS OF MAKING, AND METHODS OF USING THEREOF | 05-02-2013 |
20130099196 | Semiconductor-Graphene Hybrids Formed Using Solution Growth - A novel method for fabrication of hybrid semiconductor-graphene nanostructures in large scale by floating graphene sheets on the surface of a solution is provided. Using this approach, crystalline ZnO nano/micro-rod bundles on graphene fabricated using chemical vapor deposition were prepared. UV detectors fabricated using the as-prepared hybrid ZnO-graphene nano-structure with graphene being one of the two electrodes show high sensitivity to ultraviolet light, suggesting the graphene remained intact during the ZnO growth. This growth process provides a low-cost and robust scheme for large-scale fabrication of semiconductor nanostructures on graphene and may be applied for synthesis of a variety of hybrid semiconductor-graphene nano-structures demanded for optoelectronic applications including photovoltaics, photodetection, and photocatalysis. | 04-25-2013 |
20130096070 | PEPTIDE TARGETING OF INNER EAR CELLS - Peptide targeting moieties that target the cells of the inner ear can be used for targeted therapeutics. As such, nucleic acids and/or drugs can be associated with the targeting moieties in order to provide therapeutics that are delivered to specific cells in the inner ear. Conjugation of drugs or gene therapy vectors to cell specific peptides may allow the treatment of individual cell types within the inner ear. The peptide targeting moieties can be polypeptides having the sequences of Table 1 in an unnatural configuration. The polynucleotide can either consist of the sequence or include additional polypeptides attached to the ends of the sequences shown in Table 1. The polynucleotide can be in a non-native configuration. For example, the polypeptide is selected from the following: a-h-p-h-h-s-m (SEQ ID NO: 12); h-p-h-h-r-i-f (SEQ ID NO: 29); t-v-p-q-l-t-t (SEQ ID NO: 1); s-t-t-k-l-a-l (SEQ ID NO: 2); m-e-g-y-i-h-r (SEQ ID NO: 3); h-a-i-y-p-r-h (SEQ ID NO: 5); h-s-r-l-l-d-q (SEQ ID NO: 6); i-q-s-p-h-f-f (SEQ ID NO: 7); or y-a-a-h-r-s-h (SEQ ID NO: 8). | 04-18-2013 |
20130023796 | METHOD AND APPARATUS FOR MEASURING NON-NUTRITIVE SUCK PATTERN STABILITY - Method and apparatus are provided for generating an index associated with non-nutritive suck pattern stability. An example apparatus can include an STI generator configured to generate a plurality of non-nutritive suck (NNS) pressure samples using a non-nutritive pacifier and a pressure transducer, and to sum a plurality of standard deviations based on the plurality of NNS pressure samples to provide a spatiotemporal index (STI) of non-nutritive suck pattern stability, wherein the STI is configured to provide a composite indication of variability of amplitude, and duration of a plurality of portions of the NNS pressure samples. | 01-24-2013 |
20130018172 | Metal Abstraction Peptide and Uses Thereof - Compositions comprising certain tripeptides which are capable of binding a metal in a square planar orientation, a square pyramidal orientation, or both, are disclosed in processes for modulating tagged peptides or proteins. Such compositions and processes may be used for site-specific chiral inversion of amino acids, site-specific peptide cleavage, and protein purification, among other uses. | 01-17-2013 |
20130005831 | RAPIDLY DISSOLVING PHARMACEUTICAL COMPOSITIONS COMPRISING PULLULAN - The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent. | 01-03-2013 |
20120329987 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 12-27-2012 |
20120328678 | Hydrogel Networks Having Living Cells Encapsulated Therein - The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”). | 12-27-2012 |
20120309702 | DYNAMIC INHIBITORS OF HEAT SHOCK PROTEIN 90 - An inhibitor of heat shock protein 90 (HSP90) can include a coumermycin A1 analog having a structure that inhibits HSP90 greater than coumermycin A1. That is, the coumermycin A1 analog is not coumermycin A1. The coumermycin A1 analog can have an antiproliferative biological activity, which can be superior to coumermycin A1. The activity can include the coumermycin A1 analog inhibiting a C-terminus of HSP90. | 12-06-2012 |
20120270313 | Compositions and Methods for Establishing and Maintaining Stem Cells in an Undiffferentiated State - The present invention embraces compositions and methods for establishing and maintaining stem cells and inhibiting stem cell differentiation using a selective Protein Kinase C (PKC) inhibitor. | 10-25-2012 |
20120269510 | DIGITAL SUBCARRIER OPTICAL NETWORK UTILIZING DIGITAL SUBCARRIER CROSS-CONNECTS WITH INCREASED ENERGY EFFICIENCY - The present invention provides reduced power dissipation and other benefits at the optical transport network layer by utilizing a digital subcarrier optical network comprising multiple digital subcarrier cross-connect switches. This offers several advantages for optical networks, including spectral efficiency and robustness against signal corruption and consumption of less energy than traditional TDM-based electric switches (OTN/SONET/SDH). | 10-25-2012 |
20120259005 | BRCA1-Based Breast or Ovarian Cancer Prevention Agents and Methods of Use - A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically acceptable salt thereof, or analog thereof; and a pharmaceutically acceptable carrier containing the compound. The pharmaceutically acceptable carrier can be configured for oral, systemic, transdermal, intranasal, suppository, parenteral, intramuscular, intravenous, or subcutaneous administration. The compound can be present in the composition in a therapeutically effective amount for treating, inhibiting, and/or preventing breast and/or ovarian cancer. Also, the compound can be present in a therapeutically effective amount for enhancing production of BRCA1. | 10-11-2012 |
20120237107 | SYSTEM AND METHODS FOR DIGITAL EVALUATION OF CELLBLOCK PREPARATIONS - Digital evaluation of cellblock preparations to determine the type and extent of disease in order to identify the best approach for treatment without the need for additional testing or sampling. | 09-20-2012 |
20120232118 | SELECTIVE LIGANDS FOR THE DOPAMINE 3 (D3) RECEPTOR AND METHODS OF USING THE SAME - Potent and selective ligands for the dopamine 3 (D | 09-13-2012 |
20120208771 | SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS - Synthetic cholesterylamine-linkers can include derivatives of cholesterol, cholesteryl, or sitosteryl coupled through the linker to an agent for delivery into cells. The cholesterylamines are thought to mimic cholesterol in the capacity and mechanism for enhanced entry into cells. The configuration of the cholesterylamine-linker that is thought to provide for enhanced entry into cells includes a cholesterylamine that is coupled to a linker from the amine, and which linker includes a negative charge at a spatial distance from the amine of the cholesterylamine. | 08-16-2012 |
20120184590 | FORMULATIONS OF INDOLE-3-CARBINOL DERIVED ANTITUMOR AGENTS WITH INCREASED ORAL BIOAVAILABILITY - A pharmaceutical composition for treating, inhibiting, or preventing cancer can include an indole-3-carbinol derivative compound in a pharmaceutically acceptable carrier that is configured for oral administration. The indole-3-carbinol derivative compound can have antitumor activity, and oral administration can provide blood bioavailability of about 0.5% to about 25%. The pharmaceutically acceptable carrier can include a hydroxyl-fatty acid PEG monoester and/or diester. The carrier can be a hydroxyl-fatty acid PEG ester that includes 12-hydroxy stearate. The carrier can be a hydroxyl-fatty acid PEG ester that includes a PEG having from about 100 MW to about 200,000 MW. The indole-3-carbinol derivative can be 2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole. | 07-19-2012 |
20120177667 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 07-12-2012 |
20120177580 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 07-12-2012 |
20120177579 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 07-12-2012 |
20120174712 | Metal Abstraction Peptide (MAP) Tag and Associated Methods - Compositions comprising a tripeptide having the sequence XC | 07-12-2012 |
20120037364 | DELAYED GELLING AGENTS - The invention is directed to delayed gelation agents comprising a degradable polymeric cage containing therein one or more gelation agents. The cage degrades in situ, e.g, in an oil reservoir, thus releasing the gelation agent(s), which can then crosslink second polymers in situ to form a gel. | 02-16-2012 |
20110132398 | METHOD AND APPARATUS FOR ANTI-FOULING AN ANEMOMETER - An apparatus and method for adaptive materials arranged in a variety of orientations and with a wide range of attachment configurations to induce structural vibrations at extremely high frequencies. These mechanical vibrations cause fouling agents to become detached and accordingly “clean” an otherwise dirty element or wire of a hot-wire anemometer, planar or curvilinear sensor surface, or display surfaces. They also can be made to vibrate at such frequencies with such intensities that local droplets of water are either shaken off or instantaneously cavitate, thereby allowing the elements to be used in all weather conditions. | 06-09-2011 |
20110082098 | NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE - Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides methods of treating ADPKD comprising administering a therapeutically effective amount of a coumarin-3-carboxamide novobiocin analogue. Accordingly, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of mTOR pathway phosphoproteins P-mTOR, P-Akt and P-S6K, or combinations thereof. Further, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of Hsp-90 client proteins CFTR, ErbB2, c-Raf and Cdk4, or combinations thereof. | 04-07-2011 |
20110038727 | METHOD AND APPARATUS FOR PRESSURE ADAPTIVE MORPHING STRUCTURE - A method and apparatus for a novel adaptive aerostructure is presented that relies on certified aerospace materials and can therefore be applied in conventional passenger aircraft. This structure consists of a honeycomb material which cells extend over a significant length perpendicular to the plane of the cells. Each of the cells contains an inelastic pouch (or bladder) that forms a circular tube when the cell forms a perfect hexagon. By changing the cell differential pressure (CDP) the stiffness of the honeycomb can be altered. Using an external force or the elastic force within the honeycomb material, the honeycomb can be deformed such that the cells deviate from their perfect-hexagonal shape. It can be shown that by increasing the CDP, the structure eventually returns to a perfect hexagon. By doing so, a fully embedded pneumatic actuator is created that can perform work and substitute conventional low-bandwidth flight control actuators. It is shown that two approaches can be taken to regulate the stiffness of this embedded actuator. | 02-17-2011 |
20100314115 | SWELLABLE POLYMER WITH CATIONIC SITES - The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising expandable polymeric particles having cationic sites as well as labile crosslinkers and stable crosslinkers, said particle mixed with a fluid. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into a target zones in the reservoirs and when the heat and/or a suitable pH in the reservoir cause degradation of the labile crosslinker and when the particle expands, the cationic sites in the polymer adsorb to negative sites of the rock in the formation, thus diverting water to lower permeability regions and improving oil recovery. However, many other uses are possible. | 12-16-2010 |
20100314114 | SWELLABLE POLYMER WITH ANIONIC SITES - The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable polymeric particles having anionic sites and labile crosslinkers and stable crosslinkers, said particle mixed with a fluid and a cationic crosslinker that is capable of further crosslinking the particle on degradation of the labile crosslinker and exposure of the anionic sites so as to form a gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable pH of the target zone cause degradation of the labile crosslinker and the particle expands, the cationic crosslinker crosslinks the polymer to form a gel, thus diverting water to lower permeability regions and improving oil recovery. | 12-16-2010 |
20100292109 | SWELLABLE POLYMERS WITH HYDROPHOBIC GROUPS - The invention is directed to crosslinked water-soluble swellable polymers, methods for making same and their various uses. More particularly, the invention relates to a composition comprising expandable polymeric particles being made with 0.1-5% hydrophobic monomers and labile crosslinkers and stable crosslinkers, said particles mixed with a fluid. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into a well and when the heat and/or pH of the target zones in the formation cause degradation of the labile crosslinker and when the particle expands, the hydrophobic groups associate to form a hydrophobically associative polymer, thus diverting water to lower permeability regions and improving oil recovery. | 11-18-2010 |
20100232887 | BREAKAWAY CASING CONNECTION - A temporary casing is disclosed. The casing includes a primary portion capable of being driven into the ground and comprising a hollow portion wherein soil may be removed from within the primary casing portion, a detachable portion, also being capable of being driven into the ground and comprising a hollow portion wherein soil may be removed from within the detachable portion, a connection means for connecting the primary casing to the detachable portion such that the connection means enables the transfer of the driving force applied to the primary casing portion to the detachable portion in order to drive the detachable portion into the ground in association with the primary casing portion, wherein the connection means causes the detachable portion to detach from the primary portion when a threshold force is applied to the connection means and allows retrieval of at least the primary portion. | 09-16-2010 |
20100108807 | TETHERED HOVERING PLATFORM - The design and refinement of a tethered hovering platform into a feasible working system is presented. To determine a starting point for the design, a detailed historical search was conducted to find the history and the current state of such technology. Real world current needs are analyzed to produce a mission specification and to drive the preliminary vehicle design. Analysis of environmental conditions and decisions about an initial payload package are made in conjunction with motor and propeller sizing. Initial concept testing to discover feasibility and operational issues was performed; from this, instability issues were discovered. Analyzing these instability issues using known rotorcraft and momentum effects, in conjunction with flight testing, yields possible solutions to the problem. The use of constrained layer dampers as a means of passive stabilization is addressed and suggested as the preferred solution. Testing of passive constrained layer damping verifies the stability of the solution. The system components and manufacturing cost is presented in comparison to current systems using active stabilization | 05-06-2010 |
20100105630 | NOVOBIOCIN ANALOGUES AS NEUROPROTECTIVE AGENTS AND IN THE TREATMENT OF AUTOIMMUNE DISORDERS - Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders. | 04-29-2010 |
20100099865 | HEAT SHOCK PROTEIN 90 INHIBITORS - Novel compounds useful for inhibiting the 90kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. | 04-22-2010 |
20100048882 | Novobiocin Analogues as Anticancer Agents - Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents. | 02-25-2010 |
20100022635 | Heat shock protein 90 inhibitor dosing methods - The disclosure provides novel dosing regimens for Hsp90 inhibitors for use in the treatment or prevention of a neurodegenerative disorder, an autoimmune disorder, or cancer. The methods involve administering one or more doses of a therapeutically effective amount of at least one Hsp90 inhibitor to a subject in need thereof such that no more than a single dose is administered within a period of about 7 days. | 01-28-2010 |
20090182220 | SOURCE AFFINE RECONSTRUCTION FOR MEDICAL IMAGING - Performing medical imaging. The generation of medical images, which includes a Source AFFine Image REconstruction (SAFFIRE) algorithm, is based on an iterative implementation of minimum mean-square error (MMSE) estimation within an affine-transformed solution space and utilizes a matched filter bank initialization coupled with energy normalization of each successive estimate. An incoherent integration technique provides an alternative implementation strategy to either increase signal-to-noise ratio (SNR) or generalize the estimator to accommodate temporally-separated interference sources. In addition, the estimator solution may be employed to determine volumetric constraints with which to re-apply the estimator to further improve the estimation accuracy. | 07-16-2009 |
20090170842 | BRCA1-BASED BREAST OR OVARIAN CANCER PREVENTION AGENTS AND METHODS OF USE - A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically acceptable salt thereof, or analog thereof, and a pharmaceutically acceptable carrier containing the compound. The pharmaceutically acceptable carrier can be configured for oral, systemic, transdermal, intranasal, suppository, parenteral, intramuscular, intravenous, or subcutaneous administration. The compound can be present in the composition in a therapeutically effective amount for treating, inhibiting, and/or preventing breast and/or ovarian cancer. Also, the compound can be present in a therapeutically effective amount for enhancing production of BRCA1. | 07-02-2009 |
20090098209 | PHARMACEUTICAL COMPOSITIONS CONTAINING WATER-SOLUBLE DERIVATIVES OF PROPOFOL AND METHODS OF ADMINISTERING SAME VIA PULMONARY ADMINISTRATION - The present invention is directed to methods of delivering propofol derivative compounds via pulmonary administration to a mammal in order to induce or maintain anesthetized, sedated and sub-hypnotic states. | 04-16-2009 |
20080286245 | PREPARATION OF REGULATORY T CELLS USING ICAM-1 CO-STIMULATION - A method for generating a purified regulatory T cell composition having a CD4 | 11-20-2008 |
20080248102 | Rapidly Dissolving Pharmaceutical Compositions Comprising Pullulan - The present invention provides an orally dissolving capsule comprising pullulan, a plasticizer and a dissolution enhancing agent. | 10-09-2008 |
20080223578 | Polyelectrolyte Complexes as Delayed Gelling Agents for Oil and Gas Applications - A polyelectrolyte complex for the controlled or delayed gelation of a water and hydrocarbon producing subterranean formation. | 09-18-2008 |