Universite De Lausanne Patent applications |
Patent application number | Title | Published |
20140242076 | MULTISPECIFIC MUTATED ANTIBODY FAB FRAGMENTS - The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing. | 08-28-2014 |
20130273046 | PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES - The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. | 10-17-2013 |
20130211424 | ADJUSTABLE FIXATION SYSTEM FOR NEUROSURGICAL DEVICES - The system comprises at least a support ( | 08-15-2013 |
20130130991 | USE OF A PEPTIDE ENHANCING THE ABILITY OF RADIATION THERAPY TO KILL CANCER CELLS - The present invention relates to a peptide consisting essentially of the N2 sequence of the RasGAP protein, a bio logically active fragment thereof, or a variant thereof, which is useful for the preparation of a medicament for the treatment of cancer. Furthermore, it relates to a method of treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of the peptide of the invention. | 05-23-2013 |
20120192296 | PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES - The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. | 07-26-2012 |
20120022000 | USE OF A PEPTIDE IN THE TREATMENT OR PREVENTION OF METASTASIS - The present invention relates to a peptide useful for the preparation of a medicament for the treatment or prevention of metastasis. Furthermore, it relates to a method of treatment or prevention of metastasis comprising administering to a subject in need thereof, a therapeutically effective amount of the peptide of the invention. | 01-26-2012 |
20110206257 | AUTOMATIC DETECTION AND ACCURATE SEGMENTATION OF ABDOMINAL AORTIC ANEURYSM - This invention concerns an efficient algorithm for automatic and accurate segmentation of Abdominal Aortic Aneurysm (AAA). The algorithm first identifies the location of the lumen (the inner portion of aorta) and then segments it. The abdominal portion of the lumen is then found using anatomical and geometrical features. This portion of the lumen is straightened using geometrical transformation based on the smoothed centreline. The transformed lumen is then passed through a number of filters, based on geometrical, intensity, gradient and texture features, to search for the existence of the aneurysm. If aneurysm is detected, a deformable model is first initialized to the approximate borders of the aneurysm which are then refined using global and location information. | 08-25-2011 |
20110110979 | METHOD AND VACCINE FOR OPTIMIZING THE SPECIFIC IMMUNE RESPONSES - The present invention relates to a method for treating an infection or disease or lesion, in particular an HPV infection. Furthermore, it relates to a vaccine for treating a Human Papillomavirus (HPV) infection or an associated disease or lesion in a subject. | 05-12-2011 |
20110076283 | METHOD FOR PREDICTING AND DIAGNOSING BRAIN TUMOR - The present invention relates to a method for predicting or diagnosing outcome of concomitant chemo-radiotherapy of a subject suffering from brain tumor. The present invention further relates to compositions and methods for treatment or prevention of tumor resistance in a subject suffering from a brain tumor and to a kit useful for predicting or diagnosing the tumor resistance in a subject treated with concomitant chemo-radiotherapy. | 03-31-2011 |
20100318182 | CALIBRATED SHEATH WITH MARKINGS - The sheath ( | 12-16-2010 |