United Therapeutics Corporation Patent applications |
Patent application number | Title | Published |
20160107973 | SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES - The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil. | 04-21-2016 |
20160068461 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION - The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound. | 03-10-2016 |
20160051505 | COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS - This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. | 02-25-2016 |
20160030371 | COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS - This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. | 02-04-2016 |
20150376106 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 12-31-2015 |
20150299091 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 10-22-2015 |
20150266801 | SALTS OF TREPROSTINIL - Provided are novel treprostinil salts as well as methods for making treprostinil salts. | 09-24-2015 |
20150259274 | COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS - This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. | 09-17-2015 |
20150246078 | TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH MESENCHYMAL STEM CELLS - The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided. | 09-03-2015 |
20150224128 | IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES - Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars. | 08-13-2015 |
20150216909 | TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH PROSTACYCLIN-TREATED ENDOTHELIAL PROGENITOR CELLS - The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a by perproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH. | 08-06-2015 |
20150105582 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 04-16-2015 |
20140323567 | CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS - Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same. A preferred polymer has a repeating unit of the following structure: | 10-30-2014 |
20140288314 | PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS - A process provides for producing chiral prostacyclin derivatives of Formula (I) | 09-25-2014 |
20140275616 | SALTS OF TREPROSTINIL - Provided are novel treprostinil salts as well as methods for making treprostinil salts. | 09-18-2014 |
20140275262 | SOLID FORMS OF TREPROSTINIL - There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same | 09-18-2014 |
20140194520 | BUFFER SOLUTIONS HAVING SELECTIVE BACTERICIDAL ACTIVITY AGAINST GRAM NEGATIVE BACTERIA AND METHODS OF USING SAME - Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided. | 07-10-2014 |
20140193379 | TREATMENT OF VASCULOPATHY WITH PROSTACYCLIN AND MESENCHYMAL STEM CELLS - Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided. | 07-10-2014 |
20140018431 | TREPROSTINIL TREATMENT FOR INTERSTITIAL LUNG DISEASE AND ASTHMA - The present invention describes methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of interstitial lung disease or asthma, or a condition, such as pulmonary fibrosis, associated with interstitial lung disease or a condition associated with asthma. The invention also relates to kits for treatment and/or prevention of such condition that include an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof. | 01-16-2014 |
20130345471 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION - The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound. | 12-26-2013 |
20130253049 | TREATMENT FOR PULMONARY HYPERTENSION - One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration. | 09-26-2013 |
20130237567 | IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES - Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars. | 09-12-2013 |
20130195798 | COMBINATION THERAPY FOR TREATMENT OF VIRAL INFECTIONS - One can treat a viral infection by first administering at least one first antiviral compound for a first time period and then, after the end of the first time period, concurrently or subsequently administering the at least one first antiviral compound and at least one second antiviral compound for a second period. In some cases, after the end of the second period, the same at least one second antiviral compound that was administered during the second time period may be administered for a third time period without concurrent or subsequent administration of the at least one first antiviral compound. | 08-01-2013 |
20130184295 | METHOD OF IDENTIFYING THERAPIES FOR PULMONARY HYPERTENSION - The present invention is directed to a method of screening for a therapeutic agent useful for treating pulmonary hypertension comprising: contacting an erythrocyte with a candidate therapeutic agent; and detecting a presence or absence of erythrocyte-derived adenosine triphosphate, wherein a greater erythrocyte-derived adenosine triphosphate level indicates the candidate therapeutic agent has greater activity in treating pulmonary hypertension. Additionally, the present invention is directed to methods of treating pulmonary arterial hypertension by stimulating ATP release from erythrocytes through co-administration to a subject in need thereof an amount of a PDE5 inhibitor compound, and an amount of a prostacyclin compound. | 07-18-2013 |
20130150405 | IMINOSUGARS AND METHODS OF TREATING TOGAVIRAL DISEASES - Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Togaviridae family using iminosugars, such as DNJ derivatives. | 06-13-2013 |
20130096200 | TREPROSTINIL TREATMENT FOR INTERSTITIAL LUNG DISEASE AND ASTHMA - The present invention describes methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of interstitial lung disease or asthma, or a condition, such as pulmonary fibrosis, associated with interstitial lung disease or a condition associated with asthma. The invention also relates to kits for treatment and/or prevention of such condition that include an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof. | 04-18-2013 |
20130012827 | Use of Patterns in Processing on Mobile Monitoring Device and Computer System - A system include circuitry to receive information from a mobile device including ECG data representative of a beating heart, circuitry to analyze the ECG data using at least one pattern to detect a notable finding in the ECG data and circuitry to determine at least one pattern to send to the mobile device, based on the analysis of the ECG data. The system sends the at least one determined pattern to the mobile device. | 01-10-2013 |
20110184019 | Long chain N-Alkyl compounds and oxa-derivatives thereof - Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C | 07-28-2011 |
20110065754 | IMINOSUGARS AND METHODS OF TREATING FILOVIRAL DISEASES - Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Filoviridae family using iminosugars, such as DNJ derivatives. | 03-17-2011 |
20110065753 | METHODS OF TREATING POXVIRAL INFECTIONS - Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Poxyiridae family using iminosugars, such as DNJ derivatives. | 03-17-2011 |
20110065752 | METHODS OF TREATING ORTHOMYXOVIRAL INFECTIONS - Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives. | 03-17-2011 |
20100317696 | IMINOSUGARS AND METHODS OF TREATING BUNYAVIRAL AND TOGAVIRAL DISEASES - Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives. | 12-16-2010 |
20100222384 | Iminosugars and methods of treating arenaviral infections - Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Arenaviridae family using iminosugars, such as DNJ derivatives. | 09-02-2010 |
20100222383 | Iminosugars and methods of treating viral diseases - Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars. | 09-02-2010 |
20100137365 | Long chain N-alkyl compounds and oxa-derivatives thereof - Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C | 06-03-2010 |