Trustees of Boston College Patent applications |
Patent application number | Title | Published |
20150265661 | PREBIOTIC EFFECT OF SIALYLLACTOSE - Provided herein are prebiotic compositions comprising a combination of oligosaccharides such as sialyated oligosaccharides and fusocylated oligosaccharides, and uses thereof in stimulating the proliferation of beneficial intestinal micro biota, for example, of bifidobacteria, and/or in decreasing the abundance of enteric pathogens. The prebiotic compositions can further contain a probiotic, which can be a population of bifidobacteria, lactobacilli, | 09-24-2015 |
20140200458 | THREE DIMENSIONAL METAMATERIALS FROM CONFORMAL POLYMER COATING LAYERS - A manufacture for supporting propagation of terahertz waves includes a stack of layers made of a conformal protective polymer coating material; and an array of cells patterned on each of said layers, each cell including a metallic structure. | 07-17-2014 |
20140194369 | CYCLIC LACTADHERIN PEPTIDE MIMETICS AND THEIR USES - Provided herein is a new class of cyclic lactadherin peptides (cLac) that mimic the natural phosphatidylserine (PS)-binding activity of the parent lactadherin protein. These cLacs are useful as small molecule indicators of early stage of apoptosis and of treatment efficacy evaluation. | 07-10-2014 |
20140186209 | THERMOELECTRIC SKUTTERUDITE COMPOSITIONS AND METHODS FOR PRODUCING THE SAME - Compositions related to skutterudite-based thermoelectric materials are disclosed. Such compositions can result in materials that have enhanced ZT values relative to one or more bulk materials from which the compositions are derived. Thermoelectric materials such as n-type and p-type skutterudites with high thermoelectric figures-of-merit can include materials with filler atoms and/or materials formed by compacting particles (e.g., nanoparticles) into a material with a plurality of grains each having a portion having a skutterudite-based structure. Methods of forming thermoelectric skutterudites, which can include the use of hot press processes to consolidate particles, are also disclosed. The particles to be consolidated can be derived from (e.g., grinded from), skutterudite-based bulk materials, elemental materials, other non-Skutterudite-based materials, or combinations of such materials. | 07-03-2014 |
20140085711 | ACTIVE MANIPULATION OF ELECTROMAGNETIC WAVE PROPAGATION IN METAMATERIALS - An apparatus for controlling propagation of an electromagnetic wave includes a metamaterial having an array of cells, each cell containing a metallic structure having a resonant frequency; a plurality of devices integrated in the metamaterial, each of said devices being in electrical communication with a metallic structure in a cell in the array of cells; and a controller for electrically activating each of said plurality of devices to cause said resonant frequency to change, thereby causing at least one of a permeability and permittivity of the metamaterial to change. | 03-27-2014 |
20130344134 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES - Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositions that include such compounds. The invention, in part, also includes methods of using cAMP PDE-inhibiting compounds in the treatment of cAMP PDE-associated diseases and/or disorders. | 12-26-2013 |
20130315836 | NOVEL CELL-PENETRATING MARKERS OF APOPTOSIS - Provided herein are compounds useful for selectively labeling an apoptotic cell, and methods and assays using such compounds for the detection of an apoptotic cell in vivo or in a biological sample obtained from a subject. | 11-28-2013 |
20130247953 | ELECTRODE MATERIALS AND CONFIGURATIONS FOR THERMOELECTRIC DEVICES - Thermoelectric devices and associated materials and assembly methods are generally described. Certain aspects relate to electrode materials and electrode configurations for use in thermoelectric devices. In some embodiments, the inventive thermoelectric devices comprise electrodes comprising silicon, such as silicides of cobalt, iron, and/or nickel. Such electrode materials can be useful for making electrical contact with a wide variety of thermoelectric materials, including skutterudite materials. The thermoelectric devices described herein can be used to convert applied voltages to thermal gradients and or to convert thermal gradients to electricity. | 09-26-2013 |
20130244965 | ASSAYS AND METHODS FOR DETERMINING RISK OF A MACROPHAGE-MEDIATED DISEASE DEVELOPMENT IN A SUBJECT INFECTED WITH HIV - The invention is generally related to assays and methods for determining the risk of an HIV+ individual for developing a macrophage-mediated disease using measurement of soluble CD163 levels in a biological sample. The invention also provides assays and methods for monitoring efficacy of a treatment or a drug for a macrophage-mediated disease, and assays and methods for screening for agents to treat a macrophage-mediated disease in an HIV+ individual by monitoring soluble CD163 levels. | 09-19-2013 |
20130175484 | Half-Heusler Alloys with Enhanced Figure of Merit and Methods of Making - Thermoelectric materials and methods of making thermoelectric materials having a nanometer mean grain size less than 1 micron. The method includes combining and arc melting constituent elements of the thermoelectric material to form a liquid alloy of the thermoelectric material and casting the liquid alloy of the thermoelectric material to form a solid casting of the thermoelectric material. The method also includes ball milling the solid casting of the thermoelectric material into nanometer mean size particles and sintering the nanometer size particles to form the thermoelectric material having nanometer scale mean grain size. | 07-11-2013 |
20130116434 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS - The current application describes tungsten oxo alkylidene complexes for olefin metathesis. | 05-09-2013 |
20120326097 | Half-Heusler Alloys with Enhanced Figure of Merit and Methods of Making - Thermoelectric materials and methods of making thermoelectric materials having a nanometer mean grain size less than 1 micron. The method includes combining and arc melting constituent elements of the thermoelectric material to form a liquid alloy of the thermoelectric material and casting the liquid alloy of the thermoelectric material to form a solid casting of the thermoelectric material. The method also includes ball milling the solid casting of the thermoelectric material into nanometer mean size particles and sintering the nanometer size particles to form the thermoelectric material having nanometer scale mean grain size. | 12-27-2012 |
20120323000 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS - The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis. | 12-20-2012 |
20120302710 | COMPLEXES FOR USE IN METATHESIS REACTIONS - The present invention relates generally to metal complexes, methods for preparation and uses of the same. | 11-29-2012 |
20120177561 | NANOSTRUCTURES AND METHODS FOR CHEMICALLY SYNTHESIZING NANOSTRUCTURES - The present invention generally relates to nanostructure compositions, as well as methods for the controlled synthesis of nanostructures, such as carbon nanotubes. In some embodiments, methods involving iterative growth of a nanostructure template to homogeneously produce nanostructure compositions are provided. The compositions may include nanostructures having a specific length, width, diameter, ring orientation, and/or other characteristics. Using methods described herein, nanostructures (e.g., nanotubes) having uniform properties, such as electrical conductivity, may be readily produced. The ability to provide homogeneous nanostructure compositions may be advantageous in the design and fabrication of numerous materials and electronic devices. | 07-12-2012 |
20120028892 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF - The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier and to methods for treating diabetes by administering such a pharmaceutical composition alone or in combination with other therapeutic agents. The invention is also directed to inhibitors of fructose-1,6-bisphosphatase. | 02-02-2012 |
20110245477 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS - The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents. | 10-06-2011 |
20110108778 | THERMOELECTRIC SKUTTERUDITE COMPOSITIONS AND METHODS FOR PRODUCING THE SAME - Compositions related to skutterudite-based thermoelectric materials are disclosed. Such compositions can result in materials that have enhanced ZT values relative to one or more bulk materials from which the compositions are derived. Thermo-electric materials such as n-type and p-type skutterudites with high thermoelectric figures-of-merit can include materials with filler atoms and/or materials formed by compacting particles (e.g., nanoparticles) into a material with a plurality of grains each having a portion having a skutterudite-based structure. Methods of forming thermoelectric skutterudites, which can include the use of hot press processes to consolidate particles, are also disclosed. The particles to be consolidated can be derived from (e.g., grinded from), skutterudite-based bulk materials, elemental materials, other non-Skutterudite-based materials, or combinations of such materials. | 05-12-2011 |
20110015430 | CATALYSTS AND PROCESSES FOR THE FORMATION OF TERMINAL OLEFINS BY ETHENOLYSIS - The present invention relates generally to catalysts and processes for the formation of terminal olefin(s) from internal olefin(s) via ethenolysis reactions. The ethenolysis reactions may proceed with high conversion, high turnover, and/or high selectivity. | 01-20-2011 |
20100227853 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES - Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositions that include such compounds. The invention, in part, also includes methods of using cAMP PDE-inhibiting compounds in the treatment of cAMP PDE-associated diseases and/or disorders. | 09-09-2010 |