The University of Vermont and State Agricultural College Patent applications |
Patent application number | Title | Published |
20160030538 | AUGMENTING THE IMMUNE RESPONSE BY PROMOTING CELL DEATH OF IMMUNE CELLS - Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject. | 02-04-2016 |
20150157686 | TREATMENTS OF OXIDATIVE STRESS CONDITIONS - The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like. | 06-11-2015 |
20150068282 | Portable Ultrafine Particle Sizer (PUPS) Apparatus - The Portable Ultrafine Particle Sizer (PUPS) invention is provided. The PUPS is an instrument which can measure particle number concentration for particle sizes under 200 nanometers in-situ. The PUPS is a compact design for quick mounting on vehicles. Size discrimination is accomplished using a compact reverse Differential Mobility Analyzer (rDMA). Particle charging is accomplished using corona ionization. Concentration measurements are completed using a unique flexible printed circuit board electrode which can be removed for cleaning, disposal or chemical analysis of collected particles at the end of its in situ measurement life. | 03-12-2015 |
20150063596 | System and Method for Processing Signals to Enhance Audibility in an MRI Environment - A system for processing signals to enhance patient audibility of a plurality of signals in an MRI environment is provided. The system includes an acoustic measuring device for measuring sound power levels generated by the M RI and a principal frequency component identifier for identifying principal frequencies measured by the acoustic measuring device. The system also includes an audio equalizer for controlling the amplitude and frequency of each of the plurality of signals in accordance with the principal frequencies. Further provided by the system is an attenuator for attenuating an overall sound level of the signals being processed and a dynamic range compression processor. | 03-05-2015 |
20150056633 | DETECTION OF GLUTATHIONYLATED PROTEINS - The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc. As a specific example, a glutathionylated moiety on a glutathionylated protein may be reacted with an alkylating agent to form an alkylthio moiety; the alkylthio moiety may include a detection entity or otherwise be able to interact with a signaling entity. In some embodiments, other moieties on the protein may be altered or blocked before reaction of the protein with the detection entity. Such moieties on the protein may be, for instance, non-oxidized or non-glutathionylated moieties able to react with the detection entity. As a particular example, in a protein containing a glutathionylated moiety and non-glutathionylated thiol moieties, the thiol moieties may first be altered or blocked prior to reaction of the protein with the detection entity. Also provided in certain aspects of the present invention are kits for determining oxidized proteins, which may include components such as detection entities, alkylating agents, blocking agents, reducing agents, signaling entities, binding partners, antibodies, instructions, and the like. | 02-26-2015 |
20150051660 | CARDIAC PACEMAKER AND USES THEREOF - The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output. | 02-19-2015 |
20140275293 | MEASUREMENT AND ANALYSIS OF MOLECULAR INTERACTIONS - The present invention relates to methods for measuring molecular interactions in a viscoelastic material, as well as related products and kits. The methods involve, for instance, taking multiple pressure measurements in the viscoelastic material and calculating the complex modulus from the pressure measurements to produce the measurement of viscoelastic properties in the viscoelastic material. Also included in the invention are methods and systems for detecting molecular interactions in vivo. | 09-18-2014 |
20140233096 | Low Numerical Aperture Exclusion Imaging - In accordance with one embodiment of the present invention an apparatus for a low numerical aperture exclusion imaging apparatus is provided. The apparatus may include an electromagnetic illumination source for illuminating a portion of a specimen; and for collecting an image created by the electromagnetic radiation an objective lens optically coupled to the electromagnetic illuminated portion of the specimen. The apparatus also includes an optical blocking plate disposed between the objective lens and a focusing lens. The optical blocking plate is positioned to substantially block undesired electromagnetic radiation from image sources distally aligned in the same optical axis as the specimen. This invention is enhances narrow depth of field characteristics in imaging. It also enhances discreet imaging in a narrow focus field by eliminating some or most of the light which contributes to wide depth of field focus. This is useful for optical sectioning ranging from microscopy to photography. Optical sectioning provides the information necessary for 3D image reconstructions and other X Axis spatial measurements. | 08-21-2014 |
20140140975 | TREATMENTS INVOLVING GLUTAREDOXINS AND SIMILAR AGENTS - The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat a subject. Also provided in certain aspects of the present invention are kits for therapies involving glutaredoxins, methods for promoting such therapies, and the like. | 05-22-2014 |
20140037547 | NOVEL PEPTIDIC ACTIVATORS OF TYPE I cGMP DEPENDENT PROTEIN KINASES AND USES THEREOF - The present invention relates to cGMP protein kinase (PKG) and regulatory domains and methods of use thereof. The structural determination of PKG domains is also described. cGMP independent PKG activators and uses thereof are also described. | 02-06-2014 |
20130324468 | METHODS OF TREATING DISEASES ASSOCIATED WITH PPARy - The invention relates to methods for modulating PPAR-γ activity using relaxin or agonists thereof. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including small vessel disorders of the brain and those associated with increased blood-brain barrier permeability, cognitive disorders such as Alzheimer's disease, vascular dementia, epilepsy, stroke, CADASIL and migraine. | 12-05-2013 |
20120183794 | WHEY-PROTEIN BASED ENVIRONMENTALLY FRIENDLY WOOD ADHESIVES AND METHODS OF PRODUCING AND USING THE SAME - Wood adhesives and methods of production and application of wood adhesives are provided. The adhesives may contain proteins, and specifically may include whey proteins derived from dairy processing. Products utilizing whey-based wood adhesives are also provided as are paper adhesives that include whey protein. | 07-19-2012 |
20110313977 | Systems and Methods for Reservoir Sampling of Streaming Data and Stream Joins - Algorithms and concepts for maintaining uniform random samples of streaming data and stream joins. These algorithms and concepts are used in systems and methods, such as wireless sensor networks and methods for implementing such networks, that generate and handle such streaming data and/or stream joins. The algorithms and concepts directed to streaming data allow one or more sample reservoirs to change size during sampling. When multiple reservoirs are maintained, some of the algorithms and concepts periodically reallocate memory among the multiple reservoirs to effectively utilize limited memory. The algorithms and concepts directed to stream joins allow reservoir sampling to proceed as a function of the probability of a join sampling operation. In memory limited situations wherein memory contains the sample reservoir and a join buffer, some of the stream join algorithms and concepts progressively increase the size of the sampling reservoir and reallocate memory from the join buffer to the reservoir. | 12-22-2011 |
20110206755 | METHODS AND PRODUCTS FOR MANIPULATING UNCOUPLING PROTEIN EXPRESSION - The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is expressed in the lysosomal membrane under certain metabolic conditions. Thus the invention is methods, products, screening assays and kits relating to the manipulation of UCP expression within cellular and intracellular membranes. | 08-25-2011 |
20100219842 | Detection Circuit for Use in Various Types of Capacitive Transducers and a Transducer Including Such a Circuit - A detection circuit for detecting changes in capacitance. The detection circuit includes a tuned ratio circuit and an alternating current (AC) source AC-coupled to the tuned ratio circuit. The tuned ratio circuit includes first and second tuned circuits that are tuned to, or close, to the frequency of the AC source. Output circuitry is coupled between the two tuned circuits. During use as a transducer, an active capacitive transducer is inductively coupled to the first tuned circuit. Changes in the capacitance of the active capacitive transducer cause changes in the tuning of the first tuned circuit. The output circuitry generates an output signal that is a function of the difference between the tunings of the first and second tuned circuits. | 09-02-2010 |
20100179955 | Relational Pattern Discovery Across Multiple Databases - A system and method of identifying relational patterns across a plurality of databases using a data structure and the data structure itself. The data structure including one or more data node branches, each of the one or more data node branches including one or more data nodes, each of the one or more data nodes representing a data item of interest and corresponding data item support values for the data item across the plurality of databases in relation to other data items represented in the data node branch. The data structure can be used to mine one or more relational patterns considering pattern support data across the plurality of databases at the same time. | 07-15-2010 |
20100072759 | Piezoelectric Vibrational Energy Harvesting Systems Incorporating Parametric Bending Mode Energy Harvesting - Vibrational energy harvesting (VEH) structures that include resonant beams each having a fundamental resonance frequency and a parametric mode frequency and including at least one piezoelectric layer for generating electrical charge in response to each of fundamental-resonance excitation and parametric-mode excitation of that beam. Circuitry is provided for harvesting the electrical charge from the resonant beam. In some embodiments, the parametric mode frequency of the beam is tuned to be close to its fundamental resonance frequency so as to increase the effective bandwidth of a VEH structure. The effective bandwidth of a VEH structure can be further increased by tuning ones of multiple parametric-mode-enabled resonant beams to slightly different fundamental resonance frequencies and parametric mode frequencies. | 03-25-2010 |
20090220791 | Mesoporous Inorganic Oxide Spheres and Method of Making Same - A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to produce mesostructured inorganic oxide particles and removing organic material from the mesostructured inorganic oxide particles to form the mesoporous inorganic oxide spherical particles. In one embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and a source of fluoride. In another embodiment a reaction mixture includes a proton donor, a source of inorganic oxide, and an alcohol. Mesoporous inorganic oxide spheres produced by the method of the present invention are also provided. | 09-03-2009 |
20090091757 | System and Method for Detecting and Analyzing Particles Utilizing Online Light Scattering and Imaging Techniques - A chromatographic system that includes a light source and an imaging and analysis system for detecting particle size and analyzing other characteristics of particles in the effluent of a filtration column while filtration is ongoing. The effluent is directed into a guiding tube having a flow axis. Coherent light from the light source is shone into the guiding tube along the flow axis, thereby illuminating particles in the effluent within the guiding tube. An imaging device is used to capture images of the portion of the light scattered by the particles. The image signals are analyzed and used to provide information regarding particle size and other characteristics of the particles in the effluent scattering the light. | 04-09-2009 |
20080249734 | Method of Making a Decision on the Status of a Mechanical System Using Input and Response Data Acquired In Situ - An in-situ monitoring system is engaged with a mechanical system for which it is desired to assess or monitor the in-situ performance of the mechanical system. The in-situ monitoring system includes at least one input sensor and at least one output sensor for collecting data corresponding, respectively, to input into, and output from, the mechanical system. The monitoring system also includes an analyzer that utilizes the input and output data to generate an in-situ response representation of the mechanical system. The in-situ representation may be used to make a decision regarding the status of the mechanical system, e.g., to replace all or part of it, to adjust it or to do nothing. In one embodiment, the analyzer is programmed to adapt to the operating conditions of the mechanical system by automatically selecting which one of a number of target representations should be used to characterize the in-situ representation. | 10-09-2008 |