The University of Massachusetts Patent applications |
Patent application number | Title | Published |
20150375262 | METHOD OF FORMING ORIENTED BLOCK COPOLYMER LINE PATTERNS, BLOCK COPOLYMER LINE PATTERNS FORMED THEREBY, AND THEIR USE TO FORM PATTERNED ARTICLES - A block copolymer film having a line pattern with a high degree of long-range order is formed by a method that includes forming a block copolymer film on a substrate surface with parallel facets, and annealing the block copolymer film to form an annealed block copolymer film having linear microdomains parallel to the substrate surface and orthogonal to the parallel facets of the substrate. The line-patterned block copolymer films are useful for the fabrication of magnetic storage media, polarizing devices, and arrays of nanowires. | 12-31-2015 |
20150297363 | Prosthetic Limb - A prosthetic limb includes a plurality of extendable segments configured to adjust the length of the prosthetic limb. Also included is a first end assembly operatively coupled to the plurality of extendable segments, wherein the first end assembly is radially adjustable to manipulate the thickness of the prosthetic limb. Further included is a second end assembly operatively coupled to the plurality of extendable segments, wherein the second end assembly is radially adjustable to manipulate the thickness of the prosthetic limb. | 10-22-2015 |
20150178048 | GENERATE RANDOM NUMBERS USING METASTABILITY RESOLUTION TIME - A mechanism is provided for a circuit for generation of a random output. A bistable circuit has two stable states as an output and a clock signal as an input. The bistable circuit includes a first logic circuit and a second logic circuit cross-coupled connected together, which transition into a metastable state before resolving to the two stable states. The second logic circuit resolves to a stable state at a resolution time. A digitization circuit is configured to generate random bits corresponding to a variance of the resolution time of the second logic circuit resolving from the metastable state to the stable state for cycles of the clock signal. The resolution time randomly varies according to noise. An actual value of the stable state is eliminated as factor in generating the random bits. | 06-25-2015 |
20140175579 | METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media. | 06-26-2014 |
20140148445 | Methods of Detecting Amyotrophic Lateral Sclerosis (ALS) - In one aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising detecting one or more alterations in a profilin 1 (PFN1) sequence of an individual in need thereof compared to a wild type profilin sequence. In another aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising selectively sequencing a profilin 1 (PFN1) sequence of an individual in need thereof; and detecting one or more alterations in the PFN1 sequence of the individual. If the one or more alterations are detected then the individual has ALS. | 05-29-2014 |
20130253140 | REINFORCED POLYMETRIC MATERIALS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a low molecular weight compound that exists in the form of a second crystalline phase; wherein the second crystalline phase is dispersed within the first organic polymer phase. Disclosed herein too is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a second phase that comprises a crystalline organic polymer, wherein the crystalline organic polymer has a different molecular structure from the first organic polymer; wherein the second phase is not covalently bonded to the first organic polymer phase and wherein the second phase has an average particle size of about 1 to about 20 micrometers. | 09-26-2013 |
20130234017 | TEMPERATURE-CONTROLLED ELECTROSPRAY IONIZATION SOURCE AND METHODS OF USE THEREOF - Disclosed herein is an electrospray ionization source that provides improved temperature control compared to prior sources. A combination of a continuous flow sample design and the use of a long heat shield combine to improve thermal control and reduce memory effects observed with prior designs. The temperature-controlled source is particularly useful for the study of biomolecules, particularly the study of protein aggregation. | 09-12-2013 |
20130230492 | GENETIC INHIBITION BY DOUBLE-STRANDED RNA - A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. | 09-05-2013 |
20130189766 | NANOPARTICLE-TEXTURED SURFACES AND RELATED METHODS FOR SELECTIVE ADHESION, SENSING AND SEPARATION - Textured heterogeneous surfaces and related articles as can be used in conjunction with methods for selective sensing and/or separation. | 07-25-2013 |
20130157337 | TEMPLATE-DIRECTED ASSEMBLY OF RECEPTOR SIGNALING COMPLEXES - Transmembrane receptors in the signaling pathways of bacterial chemotaxis systems influence cell motility by forming noncovalent complexes with the cytoplasmic signaling proteins to regulate their activity. The requirements for receptor-mediated activation of CheA, the principal kinase of the | 06-20-2013 |
20120321675 | METHODS OF INHIBITING CATARACTS AND PRESBYOPIA - Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a β | 12-20-2012 |
20120251699 | ANTIMICROBIAL DELIVERY SYSTEMS, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF - Disclosed herein is an antimicrobial delivery system comprising an electrostatic complex comprising cationic biopolymer and an anionic biopolymer, wherein the antimicrobial delivery system has antimicrobial activity in a comestible. | 10-04-2012 |
20120202749 | SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF - The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants. | 08-09-2012 |
20110271403 | Metal Resistant Plants, and Methods of Manufacture Thereof - Disclosed herein is a transgenic plant transformed with an isolated nucleic acid comprising a plant arsenite-inducible RNA-associated protein coding sequence operatively linked to a plant-expressible transcription regulatory sequence, wherein the plant arsenite-inducible RNA-associated protein (AIRAP) coding sequence encodes a polypeptide that is at least 95% identical to a polypeptide sequence of SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, or SEQ ID NO:14, wherein the plant arsenite-inducible RNA-associated protein coding sequence encodes a polypeptide that confers resistance to an environmental stress, wherein greater than or equal to about 25% of transgenic plants are resistant to an environmental stress, and wherein the environmental stress inhibits the growth of wild type plants. | 11-03-2011 |
20110177554 | SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF - The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants. | 07-21-2011 |
20110118415 | CRYSTAL NUCLEATING AGENTS, CRYSTALLINE POLYMER COMPOSITION, METHODS OF MANUFACTURE THEREOF, AND ARTICLES THEREOF - A polymer composition, including: a first copolymer, including a first monomer unit derived from a monomer of Formula A: | 05-19-2011 |
20100076940 | METHOD FOR PROVIDING MAXIMAL CONCURRENCY IN A TREE STRUCTURE - Techniques for providing maximal concurrency while ensuring no deadlock in a tree structure are provided. The techniques include accessing a minimum number of one or more nodes to perform an operation. | 03-25-2010 |
20080268239 | REINFORCED POLYMERIC MATERIALS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a low molecular weight compound that exists in the form of a second crystalline phase; wherein the second crystalline phase is dispersed within the first organic polymer phase. Disclosed herein too is a polymeric composite comprising a first organic polymer that forms a first organic polymer phase; and a second phase that comprises a crystalline organic polymer, wherein the crystalline organic polymer has a different molecular structure from the first organic polymer; wherein the second phase is not covalently bonded to the first organic polymer phase and wherein the second phase has an average particle size of about 1 to about 20 micrometers. | 10-30-2008 |
20080230514 | METHOD OF PRODUCING NANOPATTERNED TEMPLATES - Nanopatterned substrates can be prepared by a method that includes forming a block copolymer film on a substrate, annealing the block copolymer film, surface reconstructing the annealed block copolymer film, coating an etch-resistant layer on the surface reconstructed block copolymer film, etching the resist-coated block copolymer film to create an etched article comprising a nanopatterned substrate, and separating the etch-resistant layer and the block copolymer film from the nanopatterned substrate. The method is applicable to a wide variety of substrate materials, avoids any requirement for complicated procedures to produce long-range order in the block copolymer film, and avoids any requirement for metal functionalization of the block copolymer. | 09-25-2008 |
20080229444 | METAL RESISTANT PLANTS, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF - Disclosed herein is a transgenic plant transformed with an isolated polynucleotide comprising a plant arsenate reductase coding sequence operatively linked to a plant-expressible transcription regulatory sequence. Also disclosed are methods to limit metal or metal ion accumulation in a harvested plant tissue comprising growing the transgenic plant; and harvesting plant tissue having reduced metal or metal ion accumulation. Further disclosed herein is method of making a transgenic plant transformed with an isolated polynucleotide comprising a plant arsenate reductase coding sequence operatively linked to a plant-expressible transcription regulatory sequence. | 09-18-2008 |
20080207504 | SECRETED FRIZZLED RELATED PROTEIN, sFRP, FRAGMENTS AND METHODS OF USE THEREOF - The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants. | 08-28-2008 |