The Trustees of Princeton University Patent applications |
Patent application number | Title | Published |
20160139012 | METHODS AND DEVICES FOR HIGH THROUGHPUT PURIFICATION - Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes. | 05-19-2016 |
20160128818 | Scaffolds for Soft Tissue and Uses Thereof - The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation. | 05-12-2016 |
20160123833 | ELECTRICAL DETECTOR FOR LIQUID METAL LEAKS - A liquid metal leak detector system including a direct current (DC) power supply and a plurality of analog to digital converters connected to the DC power supply. Each converter includes a liquid metal switch, where the liquid metal switch is closed in event of a liquid metal leak since the liquid metal leak causes electrical continuity between a conductive sheeting and a housing for liquid metal. The converter also includes a comparator connected to both the liquid metal switch for converting an analog signal into a digital signal, wherein the digital signal is configured such that a high signal constitutes no leak and a low signal constitutes a leak. An AND gate is also connected to each of the plurality of converters for combining all of the digital signals output from the converters, the AND gate configured such that the AND gate outputs a high signal if all of its inputs are high and a low signal if any input is low. | 05-05-2016 |
20160115293 | GRAPHENE DISPERSIONS - Method of making a composition comprising graphene sheets and at least one solvent, comprising dispersing a mixture of graphene sheets and graphite particles in a solvent, wherein the graphite particles have more than about 50 layers, separating the graphene sheets and the graphite particles to obtain a dispersion of graphene sheets that contains no more than 25% of graphite particles having more than about 50 layers, based on the total number of graphite particles and graphene sheets, and flocculating the dispersion of graphene sheets. The flocculated dispersion can be added to a polymer matrix to make a composite. The composite can be formed into articles. | 04-28-2016 |
20160082134 | Nanoparticle Photoacoustic Imaging Agents - The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents. | 03-24-2016 |
20160043033 | ELECTRONIC INTERCONNECTS AND DEVICES WITH TOPOLOGICAL SURFACE STATES AND METHODS FOR FABRICATING SAME - An interconnect is disclosed with enhanced immunity of electrical conductivity to defects. The interconnect includes a material with charge carriers having topological surface states. Also disclosed is a method for fabricating such interconnects. Also disclosed is an integrated circuit including such interconnects. Also disclosed is a gated electronic device including a material with charge carriers having topological surface states. | 02-11-2016 |
20160017326 | MICRORNAS AS FUNCTIONAL MEDIATORS AND BIOMARKERS OF BONE METASTASIS - Pharmaceutical compositions that include therapeutic agents including miRNA nucleic acid sequences are provided. Methods of diagnosing and treating a subjects suffering from a bone degenerative diseases including osteolytic bone metastasis are described. | 01-21-2016 |
20150381182 | FINE-GRAIN DYNAMICALLY RECONFIGURABLE FPGA ARCHITECTURE - A field programmable gate array (FPGA) and method of reconfiguring a FPGA are disclosed. The FPGA includes a plurality of logic elements interconnected with reconfigurable switches and at least horizontal and vertical direct links A memory is coupled to the reconfigurable switches, the memory being configured to store at least two run time configurations. The reconfigurable switches are reconfigurable based on a selected run time configuration stored in the memory. The memory may be a nanoelectronic random access memory (RAM). The memory may be configured to store the at least two run time configurations for at least four logic elements. Each logic element may include a look-up-table (LUT), a flip-flop, inputs and outputs. Each logic element may include dedicated carry logic. At least four logic elements may be inter-connected with diagonal direct links | 12-31-2015 |
20150364738 | BATTERIES INCORPORATING GRAPHENE MEMBRANES FOR EXTENDING THE CYCLE-LIFE OF LITHIUM-ION BATTERIES - Embodiments of the present invention relate to energy storage devices and associated methods of manufacture. In one embodiment, an energy storage device comprises an electrolyte. An anode is at least partially exposed to the electrolyte. A selectively permeable membrane comprising a graphene-based material is positioned proximate to the anode. The selectively permeable membrane reduces a quantity of a component that is included in the electrolyte from contacting the anode and thereby reduces degradation of the anode. | 12-17-2015 |
20150329918 | JAGGED1 AS A MARKER AND THERAPEUTIC TARGET FOR BREAST CANCER BONE METASTASIS - A method of treating Jagged1 induced bone metastasis is provided. A method of analyzing patients with tumors insensitive to RANK targeting treatments, but may respond to Jagged1 or Notch targeting therapies is provided. A method of treating patients with Jagged1 induced bone metastasis is provided. A method of predicting the therapeutic of treating a cancer patient with bone metastasis is provided. A kit for treating patients with Jagged1 induced bone metastasis is provided. A kit for predicting the therapeutic outcome of treating a cancer patient with bone metastasis using RANKL inhibitors is provided. | 11-19-2015 |
20150320857 | MODIFIED LIPOPOLYSACCHARIDE GLYCOFORM AND METHOD OF USE - The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of | 11-12-2015 |
20150306067 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 10-29-2015 |
20150294742 | METHOD, APPARATUS, AND SYSTEM TO REDUCE NEUTRON PRODUCTION IN SMALL CLEAN FUSION REACTORS - The invention is for a system and method to reduce neutron production from a deuterum-helium-3 (D- | 10-15-2015 |
20150287543 | GRAPHENE-IONIC LIQUID COMPOSITES - Method of making a graphene-ionic liquid composite. The composite can be used to make electrodes for energy storage devices, such as batteries and supercapacitors. | 10-08-2015 |
20150275744 | OTTO AND DIESEL CYCLES EMPLOYING SPINNING GAS - An internal combustion engine is disclosed and includes a main cylinder and main piston that are relatively axially displaceable along a main axis to define a variable volume main working chamber. At least one valve is configured to admit air and fuel into the working chamber forming an air/fuel mixture. The main cylinder is configured to cause the air/fuel mixture in the main cylinder to spin rapidly enough to cause a substantive change in the heat capacity of the air/fuel mixture creating a spinning air/fuel mixture. The main cylinder and main piston are configured to compress the spinning air/fuel mixture to create an ignitable spinning air/fuel mixture. The spinning air/fuel mixture is ignited and the main cylinder and main piston are configured to extract mechanical energy from the ignited spinning air/fuel mixture. An exhaust valve is configured to exhaust combustion products from the main working chamber. | 10-01-2015 |
20150270497 | HIGH EFFICIENCY ORGANIC PHOTOVOLTAIC CELLS EMPLOYING HYBRIDIZED MIXED-PLANAR HETEROJUNCTIONS - A device is provided, having a first electrode, a second electrode, and a photoactive region disposed between the first electrode and the second electrode. The photoactive region includes a first photoactive organic layer that is a mixture of small molecule organic acceptor material and a small molecule organic donor material, wherein the first photoactive organic layer has a thickness not greater than 0.8 characteristic charge transport lengths; a second photoactive organic layer in direct contact with the first organic layer, wherein the second photoactive organic layer is an unmixed layer of the small molecule organic acceptor material of the first photoactive organic layer, and the second photoactive organic layer has a thickness not less than about 0.1 optical absorption lengths; and a third photoactive organic layer disposed between the first electrode and the second electrode and in direct contact with the first photoactive organic layer. The third photoactive organic layer is an unmixed layer of the small molecule organic donor material of the first photoactive organic layer and has a thickness not less than about 0.1 optical absorption lengths. | 09-24-2015 |
20150242946 | Method for bidding battery storage into hour-ahead energy markets - A method for generating bids for a look-ahead, e.g. hour-ahead, energy market is disclosed. The method includes providing a processor configured to generate a lookup table approximating a value function having four dimensions including: state of the storage system, price of electricity, prior low bid and prior high bid. The processor is configured to observe an initial numeric value for a first set of dimensions and exploiting monotonicity to update a first region of the lookup table. The processor is configured to iteratively observe subsequent numeric values for a next set of dimensions and update subsequent regions of the lookup table while exploiting monotonicity to generate the lookup table. The value function is configured with numeric values for all possible sets of dimensions, the numeric values being usable to compute optimal bids. | 08-27-2015 |
20150240215 | METHOD TO PRODUCE VIRUS IN CULTURED CELLS SUPPLEMENTED WITH ALPHA-KETOGLUTARATE - The present disclosure provides a method to enhance the production of virus in cultured fibroblasts by supplementing the cells with a TCA cycle intermediate, aketoglutarate, or a derivative thereof, wherein virus production is enhanced compared to the same method canied out in the absence of a-ketoglutarate or the derivative thereof. In view of the art, the method provides an unexpected improvement on methods routinely practiced. | 08-27-2015 |
20150238475 | INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA - Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production. | 08-27-2015 |
20150218392 | COATINGS CONTAINING FUNCTIONALIZED GRAPHENE SHEETS AND ARTICLES COATED THEREWITH - Coatings comprising functionalized graphene sheets and at least one binder. In one embodiment, the coatings are electrically conductive. | 08-06-2015 |
20150197801 | DNA BARCODING OF DESIGNER MONONUCLEOSOME AND CHROMATIN ARRAY LIBRARIES FOR THE PROFILING OF CHROMATIN READERS, WRITERS, ERASERS, AND MODULATORS THEREOF - Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof. | 07-16-2015 |
20150191765 | SYSTEMS AND METHODS TO DETECT BIOFILM STREAMER GROWTH AND THEIR USES - The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments. | 07-09-2015 |
20150177149 | MULTISCALE SPECTRAL NANOSCOPY - A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position. | 06-25-2015 |
20150157716 | Methods Of Identifying And Treating Poor-Prognosis Cancers - The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells. | 06-11-2015 |
20150155404 | SEMICONDUCTOR COATED MICROPOROUS GRAPHENE SCAFFOLDS USEFUL AS SHELL-CORE ELECTRODES AND THEIR USE IN PRODUCTS SUCH AS DYE-SENSITIZED SOLAR CELLS - A high surface area scaffold to be used for a solar cell, made of a three-dimensional percolated network of functionalized graphene sheets. It may be used in the preparation of a high surface area electrode by coating with a semiconductive material. Electronic devices can be made therefrom, including solar cells such as dye-sensitized solar cells. | 06-04-2015 |
20150136601 | Nanochannel Arrays and Their Preparation and Use for High Throughput Macromolecular Analysis - Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods. | 05-21-2015 |
20150131689 | QUANTUM CASCADE LASERS WITH IMPROVED PERFORMANCE USING INTERFACE ROUGHNESS SCATTERING - A quantum cascade laser and method of making are disclosed. The quantum cascade laser includes a plurality stages configured in a cascade structure, each stage having a quantum well emission layer and an injection layer, each stage having an upper laser level and a lower laser level. A scattering barrier is located in the quantum well emission layer, the scattering barrier being positioned such that interface roughness (IFR) scattering at the lower laser level is greater than IFR scattering at the upper laser level. The scattering barrier may be located to maximize IFR scattering for the lower laser level and/or minimize IFR scattering for the upper laser level. | 05-14-2015 |
20150126474 | BROAD SPECTRUM PRO-QUORUM-SENSING MOLECULES AS INHIBITORS OF VIRULENCE IN VIBRIOS - Using a whole-cell high-throughput screen, eleven molecules were identified that activate | 05-07-2015 |
20150114296 | LOW PRESSURE VAPOR PHASE DEPOSITION OF ORGANIC THIN FILMS - Methods for preparing organic thin films on substrates, the method comprising the steps of providing a plurality of organic precursors in the vapor phase, and reacting the plurality or organic precursors at a sub-atmospheric pressure. Also included are thin films made by such a method and apparatuses used to conduct such a method. The method is well-suited to the formation of organic light emitting devices and other display-related technologies. | 04-30-2015 |
20150097531 | SYSTEM AND METHOD FOR CONTROLLING NETWORKED, GRID-LEVEL ENERGY STORAGE DEVICES - A method for controlling an energy storage system coupled to a power grid is disclosed. The method includes providing a processor configured to receive current state information including energy level in the storage system, current energy price information and current load information from the power grid. A scalar piecewise linear value function is iteratively solved using the current state information and generating charge/discharge control information. The charge/discharge control information is transmitted to the energy storage system. | 04-09-2015 |
20150078750 | NONLINEAR FOURIER ANALYSIS IN OPTICAL SYSTEMS - A receiver configured to receive wave packets encoded with data via a nonlinear channel is disclosed. The receiver includes an input configured to receive the wave packets from the non-linear channel. The receiver also includes a processor configured to generate a transfer matrix from the received wave packets and find the representation of the transfer matrix as ratios of polynomials and compute the non-linear Fourier spectrum in which the data has been embedded. The receiver may also include a demodulator configured to demodulate the non-linear Fourier spectrum to recover the data. Periodic boundary conditions may be selected. Boundary conditions may be selected based on a non-periodic vanishing signal. The received wave packets may be configured as solitons. The nonlinear channel may be an optical channel. | 03-19-2015 |
20150075280 | Fast Response Humidity Sensor - A water content sensor is disclosed. The sensor includes a wire filament configured with a Péclet number of 1 or less. The wire filament has an electrically conductive material with an electrical resistance that varies as a function of temperature. The sensor includes a pair of electrically conductive prongs coupled to opposite ends of the wire filament. Electrically conductive stubs may be coupled to the prongs. A structural support may be coupled to the prongs. The structural support structure may be comprised of silicon. The wire filament may be coupled to driving circuitry configured to supply an electric current to the wire filament to maintain the wire filament at one of an approximately constant current, an approximately constant voltage and an approximately constant temperature. The wire filament may be platinum or titanium. | 03-19-2015 |
20150065823 | NONINVASIVE MID-INFRARED IN VIVO GLUCOSE SENSOR - A noninvasive mid-infrared in vivo glucose sensor for use in connection with the skin of a test subject is disclosed. The sensor includes a mid-infrared light source configured to deliver a light beam to the skin of the test subject, a collector element configured to collect backscattered light from the skin and direct it to the detector, and a detector element configured to measure the collected backscattered light from the skin. The mid-infrared light source may be a quantum cascade laser. The sensor may include optical fibers configured to deliver the light beam to the skin of the test subject. The collector element may be an integrating sphere or a bundle of two or more optical fibers. The sensor may also include a probe containing or connecting to optical fibers coupled to the mid-infrared light source and configured to be placed on the skin to take glucose level readings. | 03-05-2015 |
20150064153 | HIGH EFFICIENCY MICROFLUIDIC PURIFICATION OF STEM CELLS TO IMPROVE TRANSPLANTS - Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of UCB and other transplant grafts, thereby significantly improving patient outcomes. | 03-05-2015 |
20150055755 | Novel Objective for EUV Microscopy, EUV Lithography, and X-Ray Imaging - Disclosed is an imaging apparatus for EUV spectroscopy, EUV microscopy, EUV lithography, and x-ray imaging. This new imaging apparatus could, in particular, make significant contributions to EUV lithography at wavelengths in the range from 10 to 15 nm, which is presently being developed for the manufacturing of the next-generation integrated circuits. The disclosure provides a novel adjustable imaging apparatus that allows for the production of stigmatic images in x-ray imaging, EUV imaging, and EUVL. The imaging apparatus of the present invention incorporates additional properties compared to previously described objectives. The use of a pair of spherical reflectors containing a concave and convex arrangement has been applied to a EUV imaging system to allow for the image and optics to all be placed on the same side of a vacuum chamber. Additionally, the two spherical reflector segments previously described have been replaced by two full spheres or, more precisely, two spherical annuli, so that the total photon throughput is largely increased. Finally, the range of permissible Bragg angles and possible magnifications of the objective has been largely increased. | 02-26-2015 |
20150055740 | IN SPACE STARTUP METHOD FOR NUCLEAR FUSION ROCKET ENGINES - The invention is for a startup system for nuclear fusion engines in space. The combustion of hydrogen and oxygen produces heat that is used by a heat engine to produce electricity. This can be supplemented by electricity from other operating engines. The exhaust from the combustion is condensed and electrolyzed to produce hydrogen and oxygen once the engine is in operation. This provides a constant source of energy for future startups. The engine is started up at partial power in electricity generation mode and this power replaces the power from the combustion as it grows. The combustor uses the same heat engine as the nuclear engine uses for power generation. | 02-26-2015 |
20150034159 | Hole-blocking TiO2/Silicon Heterojunction for Silicon Photovoltaics - A hole-blocking silicon/titanium-oxide heterojunction for silicon photovoltaic devices and methods of forming are disclosed. The electronic device includes at least two electrodes having a current path between the two electrodes. The electronic device also includes a heterojunction formed of a titanium-oxide layer deposited over a Si layer and being disposed in the current path. The heterojunction is configured to function as a hole blocker. The first electrode may be electrically coupled to the Si layer and a second electrode may be electrically coupled to the titanium-oxide layer. The device may also include a PN junction disposed in the Si layer, in the current path. The device may also include an electron-blocking heterojunction on silicon in the current path. | 02-05-2015 |
20150012928 | QUOTA AWARE VIDEO ADAPTATION - A system for selecting one of a plurality of video versions in response to a video request by a user of a user device having a processor is disclosed. The system includes a stream selector configured to adaptively select optimized bit-rates by selecting one of the plurality of video versions to deliver to the user device. The stream selector i) estimates an expected future utility of the user at different times during a billing cycle based on a remaining data quota and ii) selects one of the plurality of video versions that maximizes a current utility plus expected future utility of the user at selection time. A user profiler may be configured to perform predictive analysis of user data usage by determining the likelihood of a user requesting a video during each time interval of the user's billing cycle and a video type including utility vector and cost vector information. A video profiler may be configured to generate a plurality of utility vectors and cost vectors, each version of a video having a different bit-rate and an associated utility vector and cost vector. | 01-08-2015 |
20140366647 | NARROW-BAND FREQUENCY FILTERS AND SPLITTERS, PHOTONIC SENSORS, AND CAVITIES HAVING PRE-SELECTED CAVITY MODES - Waveguides and electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising waveguides fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. The devices include electromagnetic splitters, filters, and sensors. | 12-18-2014 |
20140354275 | ATOMIC MAGNETOMETRY USING PUMP-PROBE OPERATION AND MULTIPASS CELLS - A magnetometer for use with a sample including an atomic vapor is disclosed. The magnetometer includes a cell containing the sample such as a multipass cell including a first mirror element and a second mirror element configured so that an incoming light beam injected into the container will reflect multiple times between the first mirror element and the second mirror element. A polarized pump light source is configured to transmit pump light through the cell and pump the sample. A polarized probe light source configured to transmit probe light through the cell and probe the sample. A detector configured to detect a polarization angle or intensity of the probe light transmitted through the sample. A processor may be configured to calculate a precession frequency of the sample based on a first probe light pulse and a frequency correction based on a second probe light pulse. | 12-04-2014 |
20140344194 | MACHINE-LEARNING ACCELERATOR (MLA) INTEGRATED CIRCUIT FOR EXTRACTING FEATURES FROM SIGNALS AND PERFORMING INFERENCE COMPUTATIONS - A machine-learning accelerator (MLA) integrated circuit for extracting features from signals and performing inference computations is disclosed. The MLA integrated circuit includes a framework of finite state machine (FSM) kernels that are machine-learning algorithms implemented in hardware. The MLA integrated circuit further includes a kernel controller having mathematical structures implemented in hardware in communication with the framework of FSM kernels. An arithmetic engine implemented in hardware within the MLA integrated circuit is in communication with the kernel controller to perform computations for the mathematical structures. In at least one embodiment, the MLA integrated circuit includes a compression decompression accelerator (CDA) implemented in hardware and coupled between a memory and the kernel controller for compressing data to be stored in the memory and for decompressing data retrieved from the memory. | 11-20-2014 |
20140342375 | MICROFLUIDIC PROCESSING OF LEUKOCYTES FOR MOLECULAR DIAGNOSTIC TESTING - Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas. | 11-20-2014 |
20140330392 | SCAFFOLDS FOR TISSUES AND USES THEREOF - The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair, and transplantation. | 11-06-2014 |
20140328763 | BIOACTIVE AMPHIPHILIC POLYMER STABILIZED NANOPARTICLES WITH ENHANCED STABILITY AND ACTIVITY - The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors. | 11-06-2014 |
20140302635 | N-DOPING OF ORGANIC SEMICONDUCTORS BY BIS-METALLOSANDWICH COMPOUNDS - The various inventions disclosed, described, and/or claimed herein relate to the field of methods for n-doping organic semiconductors with certain bis-metallosandwich compounds, the doped compositions produced, and the uses of the doped compositions in organic electronic devices. Metals can be manganese, rhenium, iron, ruthenium, osmium, rhodium, or iridium. Stable and efficient doping can be achieved. | 10-09-2014 |
20140275232 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 09-18-2014 |
20140268148 | Dual-Modulation Faraday Rotation Spectroscopy - A dual-modulation Faraday rotation spectroscopic (FRS) system is disclosed. The FRS system uses an FRS sample cell configured to subject a sample to a low frequency modulated magnetic field. The system includes a polarized laser light source configured to generate a high frequency wavelength-modulated light beam incident on the sample, the high frequency wavelength-modulated light beam being modulated at a higher frequency than the low frequency modulated magnetic field. A polarizer is configured to receive from the sample a transmitted light beam having a modulated polarization having a polarization rotation and translate the modulated polarization of the transmitted light beam into an intensity modulated beam. A photodetector is configured to detect the intensity modulated beam and generate a photodetector signal. A dual demodulator is coupled to the photodetector and is configured to demodulate the photodetector signal. | 09-18-2014 |
20140261675 | PHOTOELECTRIC CELLS INCORPORATING WRINKLES AND FOLDS TO ENHANCE EFFICIENCY AND BENDABILITY AND METHOD OF MAKING - A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 μm. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction. | 09-18-2014 |
20140257518 | MULTI-FUNCTIONAL HYBRID DEVICES/STRUCTURES USING 3D PRINTING - A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA). | 09-11-2014 |
20140249329 | C-HALOGEN BOND FORMATION - Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided. | 09-04-2014 |
20140240327 | FINE-GRAINED CPU-GPU SYNCHRONIZATION USING FULL/EMPTY BITS - A heterogeneous computing system includes a central processing unit (CPU) and a graphics processing unit (GPU). The CPU and the GPU are synchronized using a data-based synchronization scheme, wherein offloading of a kernel from the CPU to the GPU is coordinated based upon the data associated with the kernel transferred between the CPU and the GPU. By using a data-based synchronization scheme, additional synchronization operations between the CPU and the GPU are reduced or eliminated, and the overhead of offloading a process from the CPU to the GPU is reduced. | 08-28-2014 |
20140234957 | Engineered Cellular Pathways for Programmed Autoregulation of Differentiation - The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex. The system can also comprise vectors in which genes encoding additional cell fate regulators are operably linked to a promoter that is induced by a factor synthesized in response to a first stage of differentiation, so that a second stage of differentiation is triggered. | 08-21-2014 |
20140231765 | REMOTE DOPING OF ORGANIC THIN FILM TRANSISTORS - Organic electronic devices comprising “remotely” doped materials comprising a combination of at least three layers. Such devices can include “remotely p-doped” structures comprising: a channel layer comprising at least one organic semiconductor channel material; a dopant layer, which comprises at least one p-dopant material and optionally at least one organic hole transport material; and a spacer layer disposed between and in electrical contact with both the channel layer and the dopant layer, comprising an organic semiconducting spacer material; or alternatively can include “remotely n-doped” structures comprising a combination of at least three layers: a channel layer comprising at least one organic semiconductor channel material; a dopant layer which comprises at least one organic electron transport material doped with an n-dopant material; and a spacer layer disposed between and in electrical contact with the channel layer and the dopant layer, comprising an organic semiconducting spacer material. Such devices include “remotely doped” field effect transistors comprising the doped structures described above. | 08-21-2014 |
20140231750 | QUANTUM WELL INFRARED PHOTODETECTORS USING II-VI MATERIAL SYSTEMS - A quantum well infrared photodetector (QWIP) and method of making is disclosed. The QWIP includes a plurality of epi-layers formed into multiple periods of quantum wells, each of the quantum wells being separated by a barrier, the quantum wells and barriers being formed of II-VI semiconductor materials. A multiple wavelength QWIP is also disclosed and includes a plurality of QWIPs stacked onto a single epitaxial structure, in which the different QWIPs are designed to respond at different wavelengths. A dual wavelength QWIP is also disclosed and includes two QWIPs stacked onto a single epitaxial structure, in which one QWIP is designed to respond at 10 μm and the other at 3-5 μm wavelengths. | 08-21-2014 |
20140212950 | METHOD TO INCREASE THE INFECTIVITY OF VIRUS PARTICLES - A method for enhancing infectivity of HCMV virus particles is provided. | 07-31-2014 |
20140206678 | INHIBITORS OF MTOR KINASE AS ANTI -VIRAL AGENT - The present invention provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mTOR. The invention also provides methods for treating or preventing viral infections using modulators of host cell enzymes relating to mTOR and modulators of the unfolded protein response. | 07-24-2014 |
20140206555 | Nanochannel Arrays and Their Preparation and Use for High Throughput Macromolecular Analysis - Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods. | 07-24-2014 |
20140190244 | System and Method for the Determination of Mixture Averaged Molecular Weight of Complex Mixtures - An apparatus and method for determining the average molecular weight of a complex mixture from a plurality of test samples of the complex mixture are disclosed. The method includes a) providing a chamber having two fixed conditions and one variable condition selected from three state variables of temperature, pressure and volume; b) introducing a test sample of known mass into the chamber; c) setting operating conditions of the state variables such that the test sample will be fully vaporized into a gaseous state without decomposition or chemical reaction; and d) measuring the change of the variable condition after full vaporization of the test sample is achieved. Steps b-d are repeated for several test samples having different masses. The average molecular weight of the complex mixture is determined as a linear gradient (slope) of the relationship for the change of variable condition as a function of test sample mass. | 07-10-2014 |
20140177178 | PRINTED ELECTRONICS - Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed. | 06-26-2014 |
20140154668 | Structures for Enhancement of Local Electric Field, Light Absorption, Light Radiation, Material Detection and Methods for Making and Using of the Same. - This disclosure provides, among other things, a nanosensor comprising a substrate and one or a plurality of pillars extending from a surface of the substrate, where the pillars comprise a metallic dot structure, a metal disc, and a metallic back plane. The nanosensor comprises a molecular adhesion layer that covers at least a part of the metallic dot structure, the metal disc, and/or the metallic back plane and a capture agent bound to the molecular adhesion layer. The nanosensor amplifies a light signal from an analyte, when the analyte is specifically bound to the capture agent. | 06-05-2014 |
20140142001 | ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES - A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y β-nucleophile substituted aldehydes and/or ketones, x•z α-electrophile substituted aldehydes and/or ketones or x•y•z β-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced. | 05-22-2014 |
20140133479 | System and Method for Synchronizing Phases and Frequencies of Devices in Multi-User, Wireless Communications Systems - A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for. Acoustic and radio-frequency signaling can be utilized. | 05-15-2014 |
20140130853 | WUSTITE-BASED PHOTOELECTRODES WITH LITHIUM, HYDROGEN, SODIUM, MAGNESIUM, MANGANESE, ZINC AND NICKEL ADDITIVES - A photoelectrode, photovoltaic device and photoelectrochemical cell and methods of making are disclosed. The photoelectrode includes an electrode at least partially formed of FeO combined with at least one of lithium, hydrogen, sodium, magnesium, manganese, zinc, and nickel. The electrode may be doped with at least one of lithium, hydrogen, and sodium. The electrode may be alloyed with at least one of magnesium, manganese, zinc, and nickel. | 05-15-2014 |
20140128287 | SYSTEMS FOR INDUCTION OF GENE EXPRESSION AND PROTEIN DEPLETION IN YEAST - A system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that is responsive to hormone inducer. Upon addition of the hormone, cytoplasmic transcriptional activator localizes to the nucleus and subsequently binds to promoters containing sequences that bind to its DNA-binding domain. Genetic modifications allow for rapid and specific degradation of a targeted protein upon addition of hormone by means of a regulated degron method that utilizes a protease variant. This system is useful for discovering new compounds by high throughput screening when introducing compound libraries to these protein-depleted cells. | 05-08-2014 |
20140113353 | Method to Produce Virus in Cultured Cells - A method for improving virus production in a host cell infected with the virus is provided. | 04-24-2014 |
20140111808 | OPTICAL SUBTRACTION OF MOLECULAR DISPERSION SIGNALS ENABLED BY DIFFERENTIAL OPTICAL DISPERSION SPECTROSCOPY - An apparatus and method for differential optical dispersion using a first sample and a second sample are disclosed. The apparatus includes a single frequency chirped laser source configured to generate a single frequency chirped laser beam. A first beam splitter is configured to split the single frequency chirped laser beam into first and second optical branches, the first sample being located in the first optical branch, the second sample being located in the second optical branch. A frequency shifter is located in the second optical branch, downstream of the second sample. A second beam splitter is configured to combine the first and second optical branches and generate a chirp-modulated mixed light beam. A square law detector is configured to detect the chirp-modulated mixed light beam and generate a heterodyne beatnote signal. A demodulator is configured for detection of the heterodyne beatnote signal to generate a transmission/differential optical dispersion spectrum. | 04-24-2014 |
20140107949 | MECHANICAL MEASUREMENT OF STATE OF HEALTH AND STATE OF CHARGE FOR INTERCALATION BATTERIES - A battery management system for use with a battery under test is disclosed. The system includes a container configured to hold the battery. The system also includes a stress/strain sensor. The container is configured to hold the battery in fixed relationship with respect to the stress/strain sensor. A processor is coupled to the stress/strain sensor, the processor being configured to measure the stress/strain on the battery and determine the state of health (SOH) of the battery based on the measured stress/strain and previously stored SOH relationship data for the battery. The processor may be configured to determine a state of charge (SOC) of the battery based on the measured stress/strain, the SOH of the battery and previously stored SOC relationship data for the battery. | 04-17-2014 |
20140100242 | INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA - Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production. | 04-10-2014 |
20140088007 | COMPOSITION FOR THE ATTACHMENT OF IMPLANTS TO COLLAGEN OR OTHER COMPONENTS OF BIOLOGICAL TISSUE - The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA. | 03-27-2014 |
20140087497 | BARRIER FILM FOR ELECTRONIC DEVICES AND SUBSTRATES - Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle θ relative to the substrate, wherein θ is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle θ | 03-27-2014 |
20140079932 | NANO-GRAPHENE AND NANO-GRAPHENE OXIDE - Nano-graphene oxide sheets or nano-graphene sheets having a maximum average lateral dimension of about 50 nm and methods of making nano-graphene oxide sheets and nano-graphene sheets. | 03-20-2014 |
20140071452 | FLUID CHANNELS FOR COMPUTATIONAL IMAGING IN OPTOFLUIDIC MICROSCOPES - A microscope is disclosed, the microscope having a light source defining an optical axis along a Z direction and a detector disposed in X-Y direction, orthogonal to the optical axis, the detector configured to capture images of an object. The microscope includes a fluid channel having an inlet and an outlet configured with a fluid flow to transport the object from the inlet to the outlet. The detector is configured to capture a plurality of images of the object as the object moves from the inlet to the outlet. The plurality of images of the object may have different heights of the sample with respect to the detector as the sample flows through the channel. The channel may be tilted with respect to the optical axis. The detector may be tilted with respect to the optical axis. | 03-13-2014 |
20140071256 | FEMTOSECOND LASER EXCITATION TAGGING ANEMOMETRY - An apparatus for the imaging of gaseous fluid motion is disclosed. The apparatus includes a sub-nanosecond pulsed laser. The sub-nanosecond pulsed laser is configured to cause a particle species to fragment and for the recombining fragments subsequently to fluoresce. The apparatus also includes a gaseous fluid comprised of particle species. The apparatus also includes a time gated camera. The time gated camera configured to capture at least one image of the fluorescence from the recombining particle fragment species displaced after a specific time lapse following the laser pulse. Additionally, a fluid velocity can be calculated from a comparison of the image of the displaced particle species to an initial reference position and the time lapse. A Femtosecond Laser Electronic Excitation Tagging (FLEET) method of using the disclosed apparatus is also disclosed. | 03-13-2014 |
20140054574 | HYBRID LAYERS FOR USE IN COATINGS ON ELECTRONIC DEVICES OR OTHER ARTICLES - A method for protecting an electronic device comprising an organic device body. The method involves the use of a hybrid layer deposited by chemical vapor deposition. The hybrid layer comprises a mixture of a polymeric material and a non-polymeric material, wherein the weight ratio of polymeric to non-polymeric material is in the range of 95:5 to 5:95, and wherein the polymeric material and the non-polymeric material are created from the same source of precursor material. Also disclosed are techniques for impeding the lateral diffusion of environmental contaminants. | 02-27-2014 |
20140053898 | HIGH EFFICIENCY ORGANIC PHOTOVOLTAIC CELLS EMPLOYING HYBRIDIZED MIXED-PLANAR HETEROJUNCTIONS - A device is provided, having a first electrode, a second electrode, and a photoactive region disposed between the first electrode and the second electrode. The photoactive region includes a first photoactive organic layer that is a mixture of an organic acceptor material and an organic donor material, wherein the first photoactive organic layer has a thickness not greater than 0.8 characteristic charge transport lengths; a second photoactive organic layer in direct contact with the first organic layer, wherein the second photoactive organic layer is an unmixed layer of the organic acceptor material of the first photoactive organic layer, and the second photoactive organic layer has a thickness not less than about 0.1 optical absorption lengths; and a third photoactive organic layer disposed between the first electrode and the second electrode and in direct contact with the first photoactive organic layer. The third photoactive organic layer is an unmixed layer of the organic donor layer of the first photoactive organic layer and has a thickness not less than about 0.1 optical absorption lengths. | 02-27-2014 |
20140051820 | Quasicrystalline Structures and Uses Thereof - This invention relates generally to the field of quasicrystalline structures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for pre-selected range of wavelengths propagating in multiple directions. | 02-20-2014 |
20140049777 | MULTI-HARMONIC INLINE REFERENCE CELL FOR OPTICAL TRACE GAS SENSING - A spectroscopic sensor and a spectroscopic method of determining a concentration of a sample are disclosed. The sensor is used in connection with a sample cell containing a sample. The sensor includes a coherent light source configured to transmit an interrogation light beam along an optical sample path directed towards the sample. The sensor also includes an in-line reference cell located in the sample path. The sensor also includes a detector having outputs responsive to absorption signals from the sample and the in-line reference cell. The sensor also includes a processor configured to isolate the reference absorption signals from the in-line reference cell and sample absorption signals from the sample cell and generate calibration information based on the reference absorption signals and determine a concentration of the sample based on the sample absorption signals. | 02-20-2014 |
20140045209 | Structures for Enhancement of Local Electric Field, Light Absorption, Light Radiation, Material Detection and Methods for Making and Using of the Same - Microstructures and nanostructures ( | 02-13-2014 |
20140030181 | NANOCOMPOSITE OF GRAPHENE AND METAL OXIDE MATERIALS - Nanocomposite materials comprising a metal oxide bonded to at least one graphene material. The nanocomposite materials exhibit a specific capacity of at least twice that of the metal oxide material without the graphene at a charge/discharge rate greater than about 10 C. | 01-30-2014 |
20140024052 | SEQUENCE-SPECIFIC EXTRACTION AND ANALYSIS OF DNA-BOUND PROTEINS - An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for down-stream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and their post-translational modification is of high scientific and pharmaceutical importance due to the role of DNA-binding proteins in the causation and development of human disease; in particular, cancer. | 01-23-2014 |
20130338178 | SIRTUIN MODULATORS AS INHIBITORS OF CYTOMEGALOVIRUS - Agents and methods of inhibiting or improving the growth of viruses are provided. | 12-19-2013 |
20130337173 | Methods and Apparatus for Depositing Material Using a Dynamic Pressure - A method of depositing organic material is provided. A carrier gas carrying organic material is ejected from a nozzle at a flow velocity that is at least 10% of the thermal velocity of the carrier gas, such that the organic material is deposited onto a substrate. In some embodiments, the dynamic pressure in a region between the nozzle and the substrate surrounding the carrier gas is at least 1 Torr, and more preferably 10 Torr, during the ejection. In some embodiments, a guard flow is provided around the carrier gas. | 12-19-2013 |
20130337078 | PARTICULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS - Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments. | 12-19-2013 |
20130309246 | JAGGED1 AS A MARKER AND THERAPEUTIC TARGET FOR BREAST CANCER BONE METASTASIS - A method of treating Jagged1 induced bone metastasis is provided. A method of analyzing patients with tumors insensitive to RANK targeting treatments, but may respond to Jagged1 or Notch targeting therapies is provided. A method of treating patients with Jagged1 induced bone metastasis is provided. A method of predicting the therapeutic of treating a cancer patient with bone metastasis is provided. A kit for treating patients with Jagged1 induced bone metastasis is provided. A kit for predicting the therapeutic outcome of treating a cancer patient with bone metastasis using RANKL inhibitors is provided. | 11-21-2013 |
20130226669 | System and Methods for Time Dependent Internet Pricing - Apparatuses, systems and methods for implementing time-dependent pricing for Internet data traffic in wireless/broadband access networks are disclosed. Such systems may include: (i) A price-optimization computational module that takes in historical and current network congestion and historical and predicted user reactions to compute the best time-dependent prices to minimize the total cost incurred to the wireless network operator; (ii) A user profiling module that takes in user reaction data to characterize a model of how much traffic that may be defer to a later point in time under a given pricing incentive; (iii) A user interface module that displays the computed prices that vary over time, so that a user (or their agent) can choose which time it should use a certain amount of mobile data; and (iv) A network measurement module that collects the actual traffic coming from each application over each period of time. | 08-29-2013 |
20130209573 | EFFICIENT, CATALYTIC AND SCALABLE METHOD TO PRODUCE CHLORINE DIOXIDE - Methods, kits, cartridges and compounds related to generating chlorine dioxide by exposing ClO | 08-15-2013 |
20130190381 | INHIBITORS OF LONG AND VERY LONG CHAIN FATTY ACID METABOLISM AS BROAD SPECTRUM ANTI-VIRALS - The present invention provides methods and compounds for treating viral infections using modulators of host cell enzymes relating to long chain fatty acid and lipid droplet metabolism. It includes a method of treating viral infections using triacsin C and its relatives, analogues and derivatives as well as other inhibitors of long chain fatty acid metabolism and lipid droplet metabolism. | 07-25-2013 |
20130168298 | METHOD FOR CONTINUOUS PARTICLE SEPARATION USING OBSTACLE ARRAYS ASYMMETRICALLY ALIGNED TO FIELDS - The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the separation of particles according to size using an array comprising a network of gaps, wherein the field flux from each gap divides unequally into subsequent gaps. In one embodiment, the array comprises an ordered array of obstacles in a microfluidic channel, in which the obstacle array is asymmetric with respect to the direction of an applied field. | 07-04-2013 |
20130098813 | BUMP ARRAY DEVICE HAVING ASYMMETRIC GAPS FOR SEGREGATION OF PARTICLES - The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. | 04-25-2013 |
20130080808 | BIOMEDICAL DEVICE FOR COMPREHENSIVE AND ADAPTIVE DATA-DRIVEN PATIENT MONITORING - A biomedical device for comprehensive and a data-driven patient monitoring is disclosed. The biomedical device includes a receiver to receive sensor data associated with physiological signals and perform feature computations on the sensor data. A control system is included to classify the sensor data using the feature computations to generate medically-relevant decisions and identify relevant data instances, and to automatically select a set of relevant data instances. A base station or programming interface can provide a patient-generic seed model to the biomedical device. The patient-specific seed model is usable by the control system to automatically select a coarse set of relevant data instances that are transmitted to the base station, which in turn analyzes the coarse set of relevant data instances to generate a patient-specific model. The biomedical device receives the patient-specific model, which is usable by the control system to automatically select a refined set of relevant data instances. | 03-28-2013 |
20130079567 | ENANTIOPURE BASE-METAL CATALYSTS FOR ASYMMETRIC CATALYSIS AND BIS(IMINO)PYRIDINE IRON ALKYL COMPLEXES FOR CATALYSIS - Disclosed herein are iron, nickel, or cobalt compounds having tridentate ligands, which can have at least one chiral moiety in the molecular structure thereof and the use of these compounds for the hydrogenation and transformation of olefins (preferably prochiral) and alkynes. | 03-28-2013 |
20130065850 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS - Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated. | 03-14-2013 |
20130064815 | INDUCING APOPTOSIS IN QUIESCENT CELLS - Compositions comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione inhibitor are provided. Methods of inhibiting or killing a quiescent cell are provided. Methods of treating cancer are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of inducing apoptosis are provided. Methods of sensitizing quiescent cells to proteasome inhibitors are provided. | 03-14-2013 |
20130033810 | PRINTED ELECTRONICS - Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed. | 02-07-2013 |
20120312456 | FLEXIBLE PIEZOELECTRIC STRUCTURES AND METHOD OF MAKING SAME - A flexible piezoelectric structure and a method of making the structure are disclosed. A piezoelectric film having a relatively high piezoelectric coefficient is attached to a flexible substrate. The piezoelectric film is fabricated on a different substrate and transferred to the flexible substrate by contact. | 12-13-2012 |
20120305165 | SELF ASSEMBLED MULTI-LAYER NANOCOMPOSITE OF GRAPHENE AND METAL OXIDE MATERIALS - Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device. | 12-06-2012 |
20120294608 | SYSTEM AND METHOD FOR BROADBAND RF INTERFERENCE CANCELLATION - Radio frequency transmission systems often suffer from the problem of co-site interference, where the frequency band of a strong radio transmitter overlaps with the frequency band of a co-located and/or remote radio receiver, such that the transmitter interferes with the ability of the receiver to detect a weak signal of interest. There is a need for a device that can process both the transmitted radio signal and the received radio signal to eliminate such interference. Previous attempts to solve this problem have been unable to cancel in-band interference in excess of 20 to 40 dB stronger than the signal of interest over a broad bandwidth, with large dynamic range, and with a high degree of linearity. Disclosed is a robust system and method for cancelling broadband in-band RF interference that operates in a dynamically changing multipath environment. | 11-22-2012 |
20120285521 | SILICON/ORGANIC HETEROJUNCTION (SOH) SOLAR CELL AND ROLL-TO-ROLL FABRICATION PROCESS FOR MAKING SAME - A photovoltaic device and method of making a photovoltaic device are disclosed. The method includes laminating an organic layer onto an inorganic semiconductor layer. A first electrical contact is electrically coupled to the organic layer and a second electrical contact is coupled to the inorganic semiconductor layer. The inorganic semiconductor layer may include a second organic layer. At least one of the organic layer and the second organic layer may form a heterojunction with the inorganic semiconductor layer. The organic layer may further comprise a metal layer. At least one of the organic layer, the inorganic semiconductor layer and the metal layer may be patterned. | 11-15-2012 |
20120275557 | Production of Radionuclide Molybdenum 99 in a Distributed and In Situ Fashion - A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator. | 11-01-2012 |
20120274929 | DETECTING SPECIES IN A DILUTE MEDIUM - Method and apparatus for detecting a species in a dilute medium, the species having a spectral feature, the apparatus comprising: a beam source arranged to generate a first laser beam and a second laser beam coherent with each other, and having a matching chirp pattern. Beam guide arranged to pass at least the first laser beam through the dilute medium; a beam mixer arranged to mix the first and the second laser beams to form a mixed beam. Detector arranged to detect, during the chirp pattern, the mixed beam and to measure changes in the mixed beam caused by refractive index variations in the dilute medium across a spectral feature. Output providing a signal that changes in response to the measured changes. | 11-01-2012 |
20120268746 | Chirp Modulation-Based Detection of Chirped Laser Molecular Dispersion Spectra - An apparatus and method for detecting refractive index variations in a sample is disclosed. The apparatus includes a multi frequency laser source configured to generate a mixed laser beam having at least two optical frequencies. A sinusoidal function generator is configured to modulate the optical frequencies to generate a chirp-modulated mixed laser beam. The chirp-modulated mixed laser beam being configured to pass through the sample. A detector is configured to detect the chirp-modulated mixed beam. A signal processer is configured to process the detected chirp-modulated mixed beam to measure refractive index variations in the sample. | 10-25-2012 |
20120255607 | SEMICONDUCTOR COATED MICROPOROUS GRAPHENE SCAFFOLDS - A high surface area scaffold to be used for a solar cell, made of a three-dimensional percolated network of functionalized graphene sheets. It may be used in the preparation of a high surface area electrode by coating with a semi conductive material. Electronic devices can be made therefrom, including solar cells such as dye-sensitized solar cells. | 10-11-2012 |
20120239871 | VIRTUAL ADDRESS PAGER AND METHOD FOR USE WITH A BULK ERASE MEMORY - A virtual address pager and method for use with a bulk erase memory is disclosed. The virtual address pager includes a page protection controller configured with a heap manager interface configured to receive only bulk erase memory-backed page requests for a plurality of memory pages. A RAM object cache controller is configured to store and bulk write data for a portion of the bulk erase memory. The page protection controller may have an operating system interface configured to generate a page memory access permission for each of the plurality of memory pages. The page protection controller may be configured to receive a virtual memory allocation request and generate the page memory access permission based on the virtual memory allocation request. | 09-20-2012 |
20120226023 | CYTOMEGALOVIRUS SURFACE PROTEIN COMPLEX FOR USE IN VACCINES AND AS A DRUG TARGET - Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection. | 09-06-2012 |
20120200168 | SYSTEM AND METHOD FOR INTERFACING LARGE-AREA ELECTRONICS WITH INTEGRATED CIRCUIT DEVICES - A system and method for interfacing large-area electronics with integrated circuit devices is provided. The system may be implemented in an electronic device including a large area electronic (LAE) device disposed on a substrate. An integrated circuit IC is disposed on the substrate. A non-contact interface is disposed on the substrate and coupled between the LAE device and the IC. The non-contact interface is configured to provide at least one of a data acquisition path or control path between the LAE device and the IC. | 08-09-2012 |
20120161209 | ELECTRONIC INTERCONNECTS AND DEVICES WITH TOPOLOGICAL SURFACE STATES AND METHODS FOR FABRICATING SAME - An interconnect is disclosed with enhanced immunity of electrical conductivity to defects. The interconnect includes a material with charge carriers having topological surface states. Also disclosed is a method for fabricating such interconnects. Also disclosed is an integrated circuit including such interconnects. Also disclosed is a gated electronic device including a material with charge carriers having topological surface states. | 06-28-2012 |
20120145234 | GRAPHENE ELECTRODES FOR SOLAR CELLS - Electrodes for dye-sensitized solar cells comprising graphene sheets and at least one binder. The electrodes may be conductive and catalytic counter electrodes. The electrodes may be flexible. | 06-14-2012 |
20120121661 | DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY - Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm | 05-17-2012 |
20120114935 | DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY - Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm | 05-10-2012 |
20120102009 | SYSTEMS AND METHODS FOR NETWORK ACCELERATION AND EFFICIENT INDEXING FOR CACHING FILE SYSTEMS - The illustrative embodiments described herein are directed to a system, methods, and computer program product, for network acceleration and efficient indexing for caching file systems. For example, the disclosed embodiments achieve (1) high compression rate, (2) low disk seeks, and (3) low memory pressure using by introducing novel features such as, but not limited to, multi-resolution chunking and intelligent load shedding. In addition, the disclosed embodiments introduces a family of HashCache policies that enable large size web caching with little or no use of main memory. | 04-26-2012 |
20120088084 | CONDUCTIVE CIRCUIT CONTAINING A POLYMER COMPOSITION CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE AND METHOD OF MAKING THE SAME - A conductive circuit containing a polymer composite, which contains at least one polymer and a modified graphite oxide material, containing thermally exfoliated graphite oxide having a surface area of from about 300 m | 04-12-2012 |
20120010281 | ANTIMICROBIAL AND ANTITUBERCULAR COMPOUNDS - Infections caused by | 01-12-2012 |
20120006728 | METHOD FOR CONTINUOUS PARTICLE SEPARATION USING OBSTACLE ARRAYS ASYMMETRICALLY ALIGNED TO FIELDS - The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the separation of particles according to size using an array comprising a network of gaps, wherein the field flux from each gap divides unequally into subsequent gaps. In one embodiment, the array comprises an ordered array of obstacles in a microfluidic channel, in which the obstacle array is asymmetric with respect to the direction of an applied field. | 01-12-2012 |
20110287241 | Graphene Tapes - Graphene tapes made by forming a film comprising graphene sheets and at least one polymeric binder and heating the film to decompose the polymer. The tapes may be used as electrodes. | 11-24-2011 |
20110268803 | LUNG TARGETING DUAL DRUG DELIVERY SYSTEM - The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases. | 11-03-2011 |
20110266529 | Remote doping of organic thin film transistors - Organic electronic devices comprising “remotely” doped materials comprising a combination of at least three layers. Such devices can include “remotely p-doped” structures comprising: a channel layer comprising at least one organic semiconductor channel material; a dopant layer, which comprises at least one p-dopant material and optionally at least one organic hole transport material; and a spacer layer disposed between and in electrical contact with both the channel layer and the dopant layer, comprising an organic semiconducting spacer material; or alternatively can include “remotely n-doped” structures comprising a combination of at least three layers: a channel layer comprising at least one organic semiconductor channel material; a dopant layer which comprises at least one organic electron transport material doped with an n-dopant material; and a spacer layer disposed between and in electrical contact with the channel layer and the dopant layer, comprising an organic semiconducting spacer material. Such devices include “remotely doped” field effect transistors comprising the doped structures described above. | 11-03-2011 |
20110257034 | METHODS FOR IDENTIFYING GENES WHICH PREDICT DISEASE OUTCOME FOR PATIENTS WITH COLON CANCER - Closures for containers and methods for using same are provided. In a general embodiment/the present disclosure provides a closure having a top portion ( | 10-20-2011 |
20110253992 | ORGANIC PHOTOSENSITIVE DEVICES USING SUBPHTHALOCYANINE COMPOUNDS - An organic photosensitive optoelectronic device includes an anode, a cathode, and a donor-acceptor heterojunction between the anode and the cathode, the heterojunction including a donor-like material and an acceptor-like material, wherein at least one of the donor-like material and the acceptor-like material includes a subphthalocyanine, a subporphyrin, and/or a subporphyrazine compound, wherein the subporphyrin or subporphyrazine compound includes boron. | 10-20-2011 |
20110251072 | ASSEMBLY OF QUASICRYSTALLINE PHOTONIC HETEROSTRUCTURES - A method and system for assembling a quasicrystalline heterostructure. A plurality of particles is provided with desirable predetermined character. The particles are suspended in a medium, and holographic optical traps are used to position the particles in a way to achieve an arrangement which provides a desired property. | 10-13-2011 |
20110205613 | WATER-DISPERSIBLE POLYANILINE FILMS CAPABLE OF UNDERGOING STABLE AND REVERSIBLE POLYELECTROCHROMIC TRANSITIONS - The present disclosure relates generally to polyaniline (PANI) materials capable of undergoing stable and reversible polyelectrochromic transitions between multiple oxidation states. More specifically, the embodiments described herein include novel PANI-PAAMPSA structures that are capable of undergoing stable and reversible transitions between the ES, LB and PB oxidation states. In some embodiments, the structures described are capable of undergoing stable transitions over a broad pH range. Also described herein are methods of preparing certain electrochromic structures. | 08-25-2011 |
20110200633 | Cytomegalovirus Surface Protein Complex for Use in Vaccines and as a Drug Target - Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection. | 08-18-2011 |
20110178224 | MULTIFUNCTIONAL GRAPHENE-SILICONE ELASTOMER NANOCOMPOSITE, METHOD OF MAKING THE SAME, AND USES THEREOF - A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m | 07-21-2011 |
20110177964 | CHEMOSENSORY ARRAYS - A chemosensor array, a method of detecting ligands in a chemical mixture and a chemosensor system are provided. Chemosensor array designs are also provided. | 07-21-2011 |
20110114897 | FUNCTIONALIZED GRAPHENE SHEETS HAVING HIGH CARBON TO OXYGEN RATIOS - Functionalized graphene sheets having a carbon to oxygen molar ratio of at least about 23:1 and method of preparing the same. | 05-19-2011 |
20110110986 | HIGH-YIELD ACTIVATION OF POLYMER SURFACES FOR COVALENT ATTACHMENT OF MOLECULES - Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed. | 05-12-2011 |
20110109203 | FLEXIBLE PIEZOELECTRIC STRUCTURES AND METHOD OF MAKING SAME - A flexible piezoelectric structure and a method of making the structure are disclosed. A piezoelectric film having a relatively high piezoelectric coefficient is attached to a flexible substrate. The piezoelectric film is fabricated on a different substrate and transferred to the flexible substrate by contact. | 05-12-2011 |
20110093082 | ENHANCED BONDING LAYERS ON TITANIUM MATERIALS - The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material. | 04-21-2011 |
20110088621 | Organic Vapor Jet Deposition Using an Exhaust - Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. The exhaust may reduce pressure buildup in the nozzles and between the nozzles and the substrate, leading to improved deposition profiles, resolution, and improved nozzle-to-nozzle uniformity. The exhaust may be in fluid communication with an ambient vacuum, or may be directly connected to a vacuum source. | 04-21-2011 |
20110068332 | Hybrid Dielectric Material for Thin Film Transistors - Thin-film transistors are made using a hybrid silica-silicone material as an insulating material. The hybrid silica-silicone material may be deposited by plasma-enhanced chemical vapor deposition from siloxanes and oxygen. These hybrid materials may be employed as the gate dielectric, as a subbing layer, and/or as a back channel passivating layer. The transistors may be made in any conventional TFT geometry. | 03-24-2011 |
20110052476 | THERMALLY EXFOLIATED GRAPHITE OXIDE - A modified graphite oxide material contains a thermally exfoliated graphite oxide with a surface area of from about 300 m | 03-03-2011 |
20110049437 | COATINGS CONTAINING FUNCTIONALIZED GRAPHENE SHEETS AND ARTICLES COATED THEREWITH - Coatings comprising functionalized graphene sheets and at least one binder. In one embodiment, the coatings are electrically conductive. | 03-03-2011 |
20110045196 | Method and Apparatus for Depositing Material Using a Dynamic Pressure - A method of depositing organic material is provided. A carrier gas carrying organic material is ejected from a nozzle at a flow velocity that is at least 10% of the thermal velocity of the carrier gas, such that the organic material is deposited onto a substrate. In some embodiments, the dynamic pressure in a region between the nozzle and the substrate surrounding the carrier gas is at least 1 Torr, and more preferably 10 Torr, during the ejection. In some embodiments, a guard flow is provided around the carrier gas. | 02-24-2011 |
20110042813 | PRINTED ELECTRONICS - Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed. | 02-24-2011 |
20110027481 | DEVICE AND METHOD FOR ORGANIC VAPOR JET DEPOSITION - A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The device includes one or more nozzles, and an apparatus integrally connected to the one or more nozzles, wherein the apparatus includes one or more source cells, a carrier gas inlet, a carrier gas outlet, and a first valve capable of controlling the flow of a carrier gas through the one or more source cells. The method includes moving a substrate relative to an apparatus, and controlling the composition of the organic material and/or the rate of the organic material ejected by the one or more nozzles while moving the substrate relative to the apparatus, such that a patterned organic layer is deposited over the substrate. | 02-03-2011 |
20100310420 | SENSORS - The invention provides sensors that are useful for detecting and measuring chemical characteristics and physical properties of compositions containing analytes. The invention further provides, among other things, methods for making the sensors and for using them, as well as modified cells having sensors of the invention therein. | 12-09-2010 |
20100285059 | Cytomegalovirus Vaccines and Methods of Production - Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed. | 11-11-2010 |
20100261914 | IAP BINDING COMPOUNDS - Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes. | 10-14-2010 |
20100197521 | ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES - A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y β-nucleophile substituted aldehydes and/or ketones, xz α-electrophile substituted aldehydes and/or ketones or xyz β-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced. | 08-05-2010 |
20100189837 | System and Method for Depositing Thin Layers on Non-Planar Substrates by Stamping - An elastomeric stamp is used to deposit material on a non-planar substrate. A vacuum mold is used to deform the elastomeric stamp and pressure is applied to transfer material from the stamp to the substrate. By decreasing the vacuum applied by the vacuum mold, the elasticity of the stamp may be used to apply this pressure. Pressure also may be applied by applying a force to the substrate and/or the stamp. The use of an elastomeric stamp allows for patterned layers to be deposited on a non-planar substrate with reduced chance of damage to the patterned layer. | 07-29-2010 |
20100116312 | SOLAR CELLS - Organic photosensitive optoelectronic devices are disclosed. The devises are thin-film crystalline organic optoelectronic devices capable of generating a voltage when exposed to light, and prepared by a method including the steps of: depositing a first organic layer over a first electrode; depositing a second organic layer over the first organic layer; depositing a confining layer over the second organic layer to form a stack; annealing the stack; and finally depositing a second electrode over the second organic layer. | 05-13-2010 |
20100112750 | Post-Processing Treatment of Conductive Polymers to Enhance Electrical Conductivity - A method for enhancing electrical conductivity of a film which includes at least one conductive polymer. The method includes providing the film comprising the at least one conductive polymer and at least one polymer acid, agitating the film in at least one reagent; and, placing the film on a heated surface. The at least one reagent includes a reagent acid that is stronger than the polymer acid. The conductivity of the treated film is significantly greater than the conductivity of the untreated film. | 05-06-2010 |
20100096597 | FUNCTIONAL GRAPHENE-RUBBER NANOCOMPOSITES - A polymer composition, containing a polymer matrix which contains an elastomer; and a functional graphene which displays no signature of graphite and/or graphite oxide, as determined by X-ray diffraction, exhibits excellent strength, toughness, modulus, thermal stability and electrical conductivity. | 04-22-2010 |
20100096595 | Functional graphene-polymer nanocomposites for gas barrier applications - A gas diffusion barrier contains a polymer matrix and a functional graphene which displays no signature of graphite and/or graphite oxide, as determined by X-ray diffraction. | 04-22-2010 |
20100059414 | BUMP ARRAY DEVICE HAVING ASYMMETRIC GAPS FOR SEGREGATION OF PARTICLES - The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ. | 03-11-2010 |
20100047615 | BARIUM-DOPED BOND COAT FOR THERMAL BARRIER COATINGS - A metallic article for high temperature applications such as a turbine engine component is protected by a thermal barrier coating system on the article's metallic substrate. The thermal barrier coating system includes a bond coat layer of aluminum containing alloy on the metal substrate, an alumina layer on the bond coat layer and a ceramic thermal barrier layer on the alumina layer. The bond coat layer is doped with elemental barium that enhances the creep resistance of the alumina layer, thus, minimizing spallation of the ceramic thermal barrier layer. | 02-25-2010 |
20100043861 | ORGANIC PHOTOVOLTAIC DEVICES - The present invention generally relates to organic photosensitive optoelectronic devices. More specifically, it is directed to organic photovoltaic devices, e.g., organic solar cells. Further, it is directed to an optimized organic solar cell comprising multiple stacked subcells in series. High power conversion efficiency are achieved by fabrication of a photovoltaic cell comprising multiple stacked subcells with thickness optimization and employing an electron blocking layer. | 02-25-2010 |
20100042824 | HARDWARE TRUST ANCHORS IN SP-ENABLED PROCESSORS - A trust system and method is disclosed for use in computing devices, particularly portable devices, in which a central Authority shares secrets and sensitive data with users of the respective devices. The central Authority maintains control over how and when shared secrets and data are used. In one embodiment, the secrets and data are protected by hardware-rooted encryption and cryptographic hashing, and can be stored securely in untrusted storage. The problem of transient trust and revocation of data is reduced to that of secure key management and keeping a runtime check of the integrity of the secure storage areas containing these keys (and other secrets). These hardware-protected keys and other secrets can further protect the confidentiality and/or integrity of any amount of other information of arbitrary size (e.g., files, programs, data) by the use of strong encryption and/or keyed-hashing, respectively. In addition to secrets the Authority owns, the system provides access to third party secrets from the computing devices. In one embodiment, the hardware-rooted encryption and hashing each use a single hardware register fabricated as part of the computing device's processor or System-on-Chip (SoC) and protected from external probing. The secret data is protected while in the device even during operating system malfunctions and becomes non-accessible from storage according to various rules, one of the rules being the passage of a certain time period. The use of the keys (or other secrets) can be bound to security policies that cannot be separated from the keys (or other secrets). The Authority is also able to establish remote trust and secure communications to the devices after deployment in the field using a special tamper-resistant hardware register in the device, to enable, disable or update the keys or secrets stored securely by the device. | 02-18-2010 |
20100029508 | NANOCHANNEL ARRAYS AND THEIR PREPARATION AND USE FOR HIGH THROUGHPUT MACROMOLECULAR ANALYSIS - Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods. | 02-04-2010 |
20090274682 | DEMETHYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE 2A - Embodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1 and/or PP2A and inhibitors prepared using such methods. Further embodiments relate to biochemical analyses of the interactions of PME-1 alone or in complex with PP2A. Further embodiments relate to compositions including mimetics and small molecules, optionally, secondary agents, which may be used to treat disorders in which PME-1 and/or PP2A activity plays a contributing role. | 11-05-2009 |
20090264307 | ARRAY-BASED POLYMORPHISM MAPPING AT SINGLE NUCLEOTIDE RESOLUTION - Disclosed herein is a system useful for detecting sequence differences (e.g., single-nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two | 10-22-2009 |
20090239244 | MODULATORS OF PROTEIN PHOSPHATASE 2A AND PP2A METHYL ESTERASE - The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A methyl esterase. The disclosure contained herein provides compounds and methods for identification of compounds that antagonize the function of PME, and thus reduce levels of PP2A demethylation activity. Over-expression or gain-of-function of PME contributes to a range of diseases such as cancer, thus inhibition of PME by antagonists may provide a strategy for therapeutic intervention. | 09-24-2009 |
20090156535 | MicroRNAs for Modulating Herpes Virus Gene Expression - An algorithm for identification of microRNA (miRNA) targets within viral and cellular RNA is disclosed. Also disclosed are essential herpes virus genes whose transcripts contain one or more targets of miRNAs encoded by herpes viruses or by host cells as predicted by the algorithm, and the use of such targets, miRNAs and their derivatives for modulating viral replication and latency. | 06-18-2009 |
20090148714 | METHOD OF PREPARING HIGH DENSITY METAL OXIDE LAYERS AND THE LAYERS PRODUCED THEREBY - A method for the production of an oxide layer, involving oxidizing a metal surface, wherein the metal surface is electrically connected to an electronic control unit (ECU);
| 06-11-2009 |
20090143515 | BRIDGED GRAPHITE OXIDE MATERIALS - Bridged graphite oxide material comprising graphite sheets bridged by at least one diamine bridging group. The bridged graphite oxide material may be incorporated in polymer composites or used in adsorption media. | 06-04-2009 |
20090127514 | ELECTROSPRAY PAINTED ARTICLE CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE AND METHOD FOR THEIR MANUFACTURE - A painted polymer part containing a conductive polymer composition containing at least one polymer and a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 05-21-2009 |
20090123843 | SUPERCAPACITOR AND BATTERY ELECTRODE CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - A supercapacitor or battery electrode containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 05-14-2009 |
20090123752 | SEPARATION MEDIUM CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - A separation medium, such as a chromatography filling or packing, containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 05-14-2009 |
20090121189 | SYNTHESIS OF BIO-FUNCTIONALIZED RARE EARTH DOPED UPCONVERTING NANOPHOSPHORS - Methods for preparing rare earth doped monodisperse, hexagonal phase upconverting nanophosphors, the steps of which include:
| 05-14-2009 |
20090111411 | System and Method for Blind Estimation of Multiple Carrier Frequency Offsets and Separation of User Signals in Wireless Communications Systems - A system and method for blind estimation of carrier frequency offsets (CFOs) and separation of user signals in wireless communications systems are provided. Blind estimation of CFOs (i.e., without knowledge of the conditions of the transmitter or the transmission medium/channel) is carried out in order to improve reception quality by a wireless communications device. A received RF signal is over-sampled by a pre-defined over-sampling factor, and polyphase components are extracted from the over-sampled signal. The polyphase components are used to construct a virtual receiver output matrix, e.g., a model of the received signal and its associated output matrix. System response conditions are blindly estimated by applying a blind system estimation algorithm to the virtual receiver output matrix. A plurality of CFO estimates are obtained from the estimated system response conditions, and can be used by an equalizer to adjust receiver parameters in accordance with the CFO estimates so as to maximize reception quality and to extract multiple user signals from the received signal. | 04-30-2009 |
20090054581 | TIRE CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - A tire, tire lining or inner tube, containing a polymer composite, made of at least one rubber and/or at least one elastomer and a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 02-26-2009 |
20090054578 | AUTOMOTIVE BODY PANEL CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - An automotive body panel containing a polymer composite formed of at least one polymer and a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 02-26-2009 |
20090054272 | EMULSIFIER CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - An emulsifier containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 02-26-2009 |
20090053437 | GAS STORAGE CYLINDER FORMED FROM A COMPOSITION CONTAINING THERMALLY EXFOLIATED GRAPHITE - A gas storage cylinder or gas storage cylinder liner, formed from a polymer composite, containing at least one polymer and a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 02-26-2009 |
20090053433 | PACKAGING MATERIAL AND FLEXIBLE MEDICAL TUBING CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - A packaging material or flexible medical tubing containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 02-26-2009 |
20090028792 | NANO-PARTICLE SURFACE MODIFICATION - Oxide, oxysulfide, halide or phosphate host particles with a self-assembled organophosphonate monolayer covalently bonded thereto. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed. | 01-29-2009 |
20090018368 | EXPEDITIOUS SYNTHESIS OF DPD - This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria | 01-15-2009 |
20090004481 | CARRIER APPLIED COATING LAYERS - Methods for bonding adherent phosphorous-containing coating layers to oxide surfaces on substrates wherein the substrates with oxide surfaces are selected from:
| 01-01-2009 |
20080312368 | WIRE COATING CONTAINING THERMALLY EXFOLIATED GRAPHITE OXIDE - A wire coating containing a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 12-18-2008 |
20080311296 | Device and Method for Organic Vapor Jet Deposition - A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The device includes one or more nozzles, and an apparatus integrally connected to the one or more nozzles, wherein the apparatus includes one or more source cells, a carrier gas inlet, a carrier gas outlet, and a first valve capable of controlling the flow of a carrier gas through the one or more source cells. The method includes moving a substrate relative to an apparatus, and controlling the composition of the organic material and/or the rate of the organic material ejected by the one or more nozzles while moving the substrate relative to the apparatus, such that a patterned organic layer is deposited over the substrate. | 12-18-2008 |
20080306225 | POLYMERIZATION METHOD FOR FORMATION OF THERMALLY EXFOLIATED GRAPHITE OXIDE CONTAINING POLYMER - A process for polymerization of at least one monomer including polymerizing the at least one monomer in the presence of a modified graphite oxide material, which is a thermally exfoliated graphite oxide with a surface area of from about 300 m | 12-11-2008 |
20080299311 | Process and Apparatus for Organic Vapor Jet Deposition - A method of fabricating an organic film is provided. A non-reactive carrier gas is used to transport an organic vapor. The organic vapor is ejected through a nozzle block onto a cooled substrate, to form a patterned organic film. A device for carrying out the method is also provided. The device includes a source of organic vapors, a source of carrier gas and a vacuum chamber. A heated nozzle block attached to the source of organic vapors and the source of carrier gas has at least one nozzle adapted to eject carrier gas and organic vapors onto a cooled substrate disposed within the vacuum chamber. | 12-04-2008 |
20080224132 | Stacked Organic Photosensitive Devices - A device is provided having a first electrode, a second electrode, a first photoactive region having a characteristic absorption wavelength λ | 09-18-2008 |
20080219662 | Monolithically Integrated Reconfigurable Optical Add-Drop Multiplexer - A reconfigurable optical add-drop mulitplexer comprises a first waveguide layer having formed therein a first multiplexer-demultiplexer, a second multiplexer-demultiplexer, and a plurality of optical switches. The reconfigurable optical add-drop multiplexer further comprises a second waveguide layer optically coupled to the first waveguide and having a second effective index of refraction, said second waveguide layer having an optical amplifier formed therein. An input signal is amplified by the optical amplifier and communicated to the first optical multiplexer-demultiplexer where the signal is demultiplexed into a plurality individual wavelength signals. The second optical multiplexer-demultiplexer is adapted to receive a multiplexed add signal and to demultiplex the add signal into component wavelength signals. The individual wavelength signals are received at the optical switches and selectively routed to either an optical detector or toward the first multiplexer-demultiplexer. The individual wavelength signals received at the first multiplexer-demultiplexer are multiplexed into an output signal. | 09-11-2008 |
20080206443 | ENHANCED BONDING LAYERS ON TITANIUM MATERIALS - The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material. | 08-28-2008 |