The Research Foundation for The State University of New York Patent applications |
Patent application number | Title | Published |
20160123862 | ELECTRICAL SYSTEMS,AND SEPARATION SAMPLING MODULES FOR USE WITHIN A BUCKET OF A CENTRIFUGE - A separation sampling module for use within a bucket of a centrifuge for monitoring separation of a sample in a container includes a housing operable for supporting the container for containing the sample and removably positionable within the bucket of the centrifuge, at least one light source for illuminating the sample, at least one light detector for detecting light from the sample, and at least one of a power source and a connector operably connectable to a power source for use in powering the at least one light source. Light from the at least one light source passing through the sample defines a light path disposed in a direction across the direction of a centrifugal force when the separation sampling module is disposed in the bucket and rotated in the centrifuge. | 05-05-2016 |
20160090636 | MicroRNA-129 AS A BIOMARKER FOR COLORECTAL CANCER - The current disclosure describes methods for identifying subjects that would benefit from treatment with a chemotherapeutic agent. The disclosure is based in part on the observation that miR-129 expression levels are reduced in colorectal cancer. Accordingly, the current disclosure provides therapeutic compositions and methods for altering the expression of a miR-129 effector. Described herein are methods for characterizing the stage of colorectal cancer in a subject, based on the levels of miR-129 expression. The disclosure also identifies miR-129 as a predictive biomarker for cancer diagnosis and the subsequent treatment with directed therapeutic agents including but not limited to miR-129 nucleic acid molecules and/or a chemotherapeutic agent. The current disclosure also identifies novel therapeutic agents that modulate the level of BCL2, TS and/or E2F3 expression, as well as sensitize a subject to treatment with a chemotherapeutic agent. | 03-31-2016 |
20160076064 | ENGINEERED STRAIN OF ESCHERICHIA COLI FOR PRODUCTION OF POLY-R-3-HYDROXYALKANOATE POLYMERS WITH DEFINED MONOMER UNIT COMPOSITION AND METHODS BASED THEREON - Methods and systems for producing prescribed unit size azido-poly(3-hydroxyalkanoate) (azido-PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one ω-azidofatty acid substrate that is equal in carbon length to the prescribed or desired unit size of an azido-PHA polymer to be produced. Azido-PHA polymers or azido-PHA co-polymers can be conjugated via copper-catalyzed alkyne-azide cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. The prescribed unit size conjugated azido-PHA polymer or orthogonally conjugated azido-PHA co-polymer that is produced is then isolated and/or purified. | 03-17-2016 |
20160051427 | FOUR BAR APPARATUS AND METHOD FOR LIFTING, LOWERING, EXERCISE AND SELF-PROPELLED TRANSIT - Disclosed is a four bar apparatus and method for lifting, lowering, providing exercise and facilitating self-propelled transit. The apparatus includes an actuator and interconnected four-bar lifting mechanism, which includes a crank, a coupler, a rocker, and a frame. Each of the crank, coupler, rocker and frame are rotatably interconnected, and operation of the actuator moves a lift point of the coupler, with the lift point connectable to a vest-type garment or belt worn by a user of the apparatus, with the lift point following a J shape path or an S shape path to lift the user from a shoulder or hip area, respectively. | 02-25-2016 |
20160038448 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES - The subject invention provides a method of reducing the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in a patient, comprising administering a compound to the patient a compound having the structure: (Formula 1) wherein R1 and R2 are each independently hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, or R1 and R2 are linked so as to form a cyclopropyl cyclobutyl, cyclopentyl, or cyclohexyl ring; wherein R3, R4, R5, R6 are each independently hydrogen, fluorine or chlorine; and wherein R7 is hydrogen, phenyl, fluorine, chlorine, bromine, hydroxyl, amine, carboxylic acid, C1-C6 alkyl carboxylate, amide, methyl, ethyl, butyl, pentyl, hexyl, or a pharmaceutically acceptable salt or ester thereof, so as to thereby reduce the presence of toxic intermediates of amyloidosis from islet amyloid polypeptide (IAPP) in the patient. | 02-11-2016 |
20160030297 | DENTAL TREATMENT METHOD AND ABUTMENT USED THEREIN - A dental treatment method is provided. In this method, a tooth of a patient is extracted and prepared to provide a root part. A root canal in the extracted tooth is prepared and treated. A post of an abutment is fitted into the root canal to attach the root part to the abutment. The abutment having the root part is attached to a dental implant. With the root part attached to the abutment, periodontal connective tissue maintains the jaw bone associated with the extracted tooth, without significant hard tissue loss. | 02-04-2016 |
20160030264 | PORTABLE INFANT INCUBATOR - A portable infant incubator is provided. The incubator has a foldable circumferential wall connected to a base. The foldable circumferential wall has a first configuration folded on a top surface of the base and a second configuration standing from the top surface of the base. A cover is operatively connected to the wall when wall is in the second configuration, to provide a substantially enclosed space with the wall and the top surface of the base. An environmental control device is provided to maintain a predetermined temperature and humidity within the enclosed space. A sensor is provided to acquire environmental data and providing the data to the environmental control device. | 02-04-2016 |
20160022542 | HOME MEDICATION MANAGER - A self medication management system and method comprising at least a plurality of receptacles, a scanner, a display screen, and a processor to acquire medication information from a medication container, determine whether the medication information exists in a first database, if the medication information does not exist in the first database, associate the medication information with a location information comprising a receptacle and store the medication information and the location information in the first database, indicate the location information, and confirm placement of the medication container in the associated receptacle, notify a user to administer the medication held in the medication container, and request the user to scan the medication container of the notified medication, detect retrieval of an incorrect medication container from the plurality of receptacles, and issue a warning of the detection, and provide instructions for administering the medication. | 01-28-2016 |
20160002607 | Adeno-Associated-Virus Rep Sequences, Vectors and Viruses - The invention provides adeno-associated virus (AAV) replication (Rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type AAV Rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type AAV Rep inhibitory amino acid sequence. The invention provides vectors, cells, and viruses containing the invention's sequences. Also provided are methods for detecting portions of the AAV Rep inhibitory amino acid sequence, which reduce replication and/or infection and/or productive infection by viruses. The invention's compositions and methods are useful for site-specific integration and/or expression of heterologous sequences by recombinant adeno-associated virus (rAAV) vectors and by rAAV virus particles, such as hybrid viruses (e.g., Ad-AAV) comprising such vectors. The invention's compositions and methods find application in, for example, gene therapy and/or vaccines. | 01-07-2016 |
20150366953 | GLAUCOMA TREATMENT - Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector. | 12-24-2015 |
20150356258 | REAL-TIME NATIONAL RADIATION DOSE DATABASE AND MONITORING RADIATION DOSAGES USING THIS DATABASE - An inventive system and method for monitoring radiation dose data comprises in one aspect, a database storing at least recommended dose data and benchmark dose data for one or more facilities, a scanner located in one facility, the scanner can perform a scan with radiation dose data, an application server, a user interface comprising at least a display, and a module, operable on the processor, to receive the radiation dose data from the scanner, store the radiation dose data, monitor the radiation dose data in accordance with effective dose data and the benchmark dose data for the facilities, and display the monitored dose data and the benchmark dose data for the facility. In one aspect, convert the radiation dose data in accordance with the recommended dose data stored in the database and obtain an effective dose data based on the converted radiation dose data. | 12-10-2015 |
20150347695 | PHYSICIAN ATTRIBUTION FOR INPATIENT CARE - A system and method for performing physician attribution is presented. In one aspect, the system can comprise instructions comprising querying a first database; extracting a plurality of data from the first database, said extracted data comprising at least a physician, a note type, a note text and a patient; storing the extracted data in a second database; computing attribution scores using predetermined weights for the note types and the plurality of notes in the extracted data; storing the attribution scores in the second database; and attributing the physician with a highest score to the patient. | 12-03-2015 |
20150322914 | HIGH-EFFICIENCY ENERGY GENERATOR FOR HARNESSING MECHANICAL VIBRATION POWER - An energy generating device utilizing mechanical vibration power is provided. The energy generating device includes a first body for reciprocating according to vibration motions; an anchored second body; a rack coupled to one of the first body and the anchored second body; a gear assembly engaged with the rack and coupled to the other one of the first body and the anchored second body such that the gear assembly drives a generator via a rotational movement in a single direction according to each of upward and downward movement of the rack relative to the gear assembly; and the generator engaged with the gear assembly for receiving the rotational movement output from the gear assembly and outputting a direct current according to the rotational input from the gear assembly. | 11-12-2015 |
20150314269 | PLASMONICALLY ACTIVE NANOCOMPOSITES WITH A BIMODAL NANOPARTICLE SIZE DISTRIBUTION - A self-regenerative metal nanocomposite comprised of a bimodal distribution of metal nanoparticles (NPs) with a metal oxide surrounding is introduced as a new type of plasmonic catalyst through a physical method. Methods of forming such nanocomposites are also disclosed. The support-free catalyst shows plentiful surface adsorbed oxygen species along with excellent localized surface plasmon resonance (LSPR) and appreciable photoluminescence (PL). The combination of high activity and durability of this plasmonic catalyst makes it viable for potential energy and cost-effective catalytic applications. | 11-05-2015 |
20150273028 | USE OF COLLAGENASE TO TREAT GLAUCOMA - Provided is a method of treatment for reducing fibrosis involving administering purified collagenase into an anterior chamber of an eye of a human patient. | 10-01-2015 |
20150246877 | ARYL TETRAFLUOROSULFANYL COMPOUNDS - The invention provides compounds of the Formula (I), methods of making the compounds, and devices comprising the compounds. | 09-03-2015 |
20150239748 | TITANATE AND TITANIA NANOSTRUCTURES AND NANOSTRUCTURE ASSEMBLIES, AND METHODS OF MAKING SAME - The invention relates to nanomaterials and assemblies including, a micrometer-scale spherical aggregate comprising: a plurality of one-dimensional nanostructures comprising titanium and oxygen, wherein the one-dimensional nanostructures radiate from a hollow central core thereby forming a spherical aggregate. | 08-27-2015 |
20150224208 | NOVEL PRODRUGS FOR SELECTIVE ANTICANCER THERAPY - The present invention provides a compound having the structure: | 08-13-2015 |
20150217002 | NEAR-INFRARED SPECTROSCOPY AND OPTICAL REPORTER - The method of the present disclosure is directed towards a method for determining the concentration of an analyte in a mammal's bloodstream. This method includes the following steps; applying a patch to the mammal's skin, the patch configured to transmit a reporter through the mammal's skin, wherein the reporter is configured to have an affinity for the analyte and is capable of exhibiting a detectable change in fluorescence upon binding to the analyte, subjecting a portion of the mammal's skin to Near Infrared Spectroscopy (NIRS), detecting fluorescence emission intensity and calculating the concentration of the analyte based on the detected fluorescence emission. The system of the present disclosure is directed towards an analyte monitoring system. The system includes the following, a patch and a receiver | 08-06-2015 |
20150183715 | ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF - The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure: | 07-02-2015 |
20150182121 | LOW-COST SCREENING SYSTEM FOR BREAST CANCER DETECTION - A portable and wearable tumor detector includes a brassier and devices for enabling optical tomography in a non-clinical setting. Light emitting devices and light sensing devices are provided on the brassier, and a controller for performing a tomographic scanning is attached to the brassier. A computing means and a communication means may be provided to generate at least one tomographic image. Each of the two breasts under examination can be employed as a reference structure for generating a tomographic image for the other of the two breasts, thereby providing a self-referencing image generation mechanism. The images and/or data can be reviewed by the subject of the tomographic scanning or by a medical professional. The tomographic scanning can be performed at any location if provided with a portable power supply system. | 07-02-2015 |
20150150834 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES - The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: | 06-04-2015 |
20150136344 | PRODUCT AND PROCESSES FROM AN INTEGRATED FOREST BIOREFINERY - An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions. | 05-21-2015 |
20150134030 | CARDIAC DEFIBRILLATION WITH VAGUS NERVE STIMULATION - A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected. | 05-14-2015 |
20150132792 | METHODS OF ASSAYING SENSITIVITY OF CANCER STEM CELLS TO THERAPEUTIC MODALITIES - The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells. | 05-14-2015 |
20150127307 | METHOD AND APPARATUS FOR CRYSTAL STRUCTURE OPTIMIZATION - Disclosed is a method and system for prediction of an optimized crystal structure using an evolutionary algorithm that includes inputting characterization information of a chemical structure and input parameters, generating a first generation of crystal structures from the characterization information using symmetrical initialization, optimizing the chemical structure of the first generation of crystal structures according to the input parameters, inputting the optimized first generation of crystal structures into a niching algorithm, producing a child group of crystal structures from the parent group of crystal structures using a variation operator, and adding the child group of crystal structures to an optimal group of crystal structures to form a next generation, with the niching algorithm selecting an optimal group of crystal structures and a parent group of crystal structures from the first generation of crystal structures, with an antiseed created for population diversity and every structure produced by the evolutionary algorithm being stored together with a width and a height of the Gaussian parameter as the antiseed. | 05-07-2015 |
20150122977 | CENTRIFUGE FORCE MICROSCOPE MODULES AND SYSTEMS FOR USE IN A BUCKET OF A CENTRIFUGE - A centrifuge force microscope module for use within a bucket of a centrifuge in measuring a characteristic of a sample under a centrifugal force and/or in monitoring a sample under a centrifugal force. The centrifuge force microscope module includes an electronics module and an optical module. The electronics module includes a housing removably disposable in the bucket of the centrifuge, and at least one of a power source and a connector operably connectable to a power source for powering the electronics module. The optical module is operable to receive and direct light from the sample. The optical module is releaseably connectable to the housing of the electronics module. | 05-07-2015 |
20150105298 | MULTI-OLIGOMER IN SITU HYBRIDIZATION PROBES - The disclosure relates to in situ hybridization probes for the detection of target nucleic acid sequences within a sample and methods of making and using the same. The in situ hybridization probes of the current disclosure include a plurality of nucleic acid elements capable of selectively hybridizing to at least a portion of a nucleic acid of interest and/or other nucleic acid elements of the in situ hybridization probe, which enable the detection of a target nucleic acid. The current disclosure also relates to kits which incorporate the in situ hybridization probe compositions of the instant disclosure. | 04-16-2015 |
20150087597 | POLYPEPTIDES AND METHODS OF USE - Described herein are fragments of fibronectin and vitronectin and variants thereof that have certain activities, including growth factor-binding activity. Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to fibronectin. Compositions containing such fragments are useful in cosmetic treatments (e.g., the treatment of wrinkles or UV photodamage of skin), and the treatment of wounds and cancer. | 03-26-2015 |
20150083893 | Method And Device For Preserving and Imaging Specimens While Retaining Information On The Spatial Orientation Of Specimens With Respect To Reference Objects - An object, such as a tumor from a breast lumpectomy, is placed into an object positioning device that can hold the object without deforming it. Such a device can include a container with a deformable foam, gel, or other material. The object positioning device is moved into an imaging device. Images of the object within the object positioning device are acquired by the imaging device. The acquired images are stored, processed, or output on a display device. Information about the spatial orientation of the object with respect to a reference object is preserved. | 03-26-2015 |
20150083594 | ELECTROPHORESIS CONTROLLERS, SENSORS, AND METHODS FOR CONTROLLING ELECTROPHORESIS PROCESSES - An electrophoresis controller for use with an electrophoresis apparatus having a gel matrix disposed between electrodes for separation of particles along with a tracking dye. The electrophoresis controller includes a sensor system and a controller. The sensor system includes a support, a light emitter, and a light receiver. The support includes a first portion positionable on a first side of the gel matrix and a second portion positionable adjacent a second side of the gel matrix. The light emitter is positioned on the first portion of the support for emitting light onto one side of the gel matrix. The light receiver is positioned on the second portion of the support adjacent to the other side of the gel matrix for receiving light from the light source as it is passing through the gel matrix. At least one of the light emitter and the light receiver includes a light guide having a first end and a second end. The first end is positioned on the support and facing the gel matrix, and the second end is remote from the sensor system. The controller is operably connected to the sensor for monitoring a change in the light from the illuminated gel matrix due to migration of the tracking dye into the illuminated gel matrix and received by the light receiver. | 03-26-2015 |
20150079393 | Molecular Organometallic Resists for EUV - Described herein are organometallic or inorganic complexes with high extreme ultraviolet (EUV) optical density (OD) and high mass density for use in thin films. These thin films are used as high resolution, low line edge roughness (LER) EUV photoresists. The complexes may also be included in nanoparticle form for use in photoresists. | 03-19-2015 |
20150073259 | SYSTEM AND METHOD FOR CT-GUIDED NEEDLE BIOPSY - An image-guided system and method for performing needle biopsy on a moving lung nodule of a body is provided. CT images of the lung nodule are obtained to generate a motion model, based on which an optimal needle advancing path is determined. The motion of the lung nodule and the motion of a fiducial marker attached to the body are correlated. The motion of the fiducial marker is tracked and monitored by a camera to determine a position of the lung nodule based on the correlation. A time for advancing the needle is determined based on a motion attribute of the reference. The needle is advanced by a robotic needle manipulator at the predetermined time along the path to accomplish the needle placement. | 03-12-2015 |
20150073021 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR - The present invention provides a method of inhibiting the binding of anthrax lethal factor with protective antigen comprising contacting the anthrax lethal factor with a compound having the structure: | 03-12-2015 |
20150044733 | FLOCCULATION OF LIGNOCELLULOSIC HYDROLYZATES - A method of separating a lignin-rich solid phase from a solution, comprising: pretreating a lignocellulosic biomass with a pretreatment fluid having to remove soluble components, colloidal material and primarily lignin containing particles; separating the pretreated lignocellulosic biomass from the pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles; flocculating the separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles using PEO or CPAM as a flocculating agent; and filtering the flocculated separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles to remove agglomerates. | 02-12-2015 |
20150041759 | COLLOIDAL NANOCRYSTALS AND METHOD OF MAKING - A tight confinement nanocrystal comprises a homogeneous center region having a first composition and a smoothly varying region having a second composition wherein a confining potential barrier monotonically increases and then monotonically decreases as the smoothly varying region extends from the surface of the homogeneous center region to an outer surface of the nanocrystal. A method of producing the nanocrystal comprises forming a first solution by combining a solvent and at most two nanocrystal precursors; heating the first solution to a nucleation temperature; adding to the first solution, a second solution having a solvent, at least one additional and different precursor to form the homogeneous center region and at most an initial portion of the smoothly varying region; and lowering the solution temperature to a growth temperature to complete growth of the smoothly varying region. | 02-12-2015 |
20150030252 | METHODS OF RECOGNIZING ACTIVITY IN VIDEO - The present invention is a method for carrying out high-level activity recognition on a wide variety of videos. In one embodiment, the invention leverages the fact that a large number of smaller action detectors, when pooled appropriately, can provide high-level semantically rich features that are superior to low-level features in discriminating videos. Another embodiment recognizes activity using a bank of template objects corresponding to actions and having template sub-vectors. The video is processed to obtain a featurized video and a corresponding vector is calculated. The vector is correlated with each template object sub-vector to obtain a correlation vector. The correlation vectors are computed into a volume, and maximum values are determined corresponding to one or more actions. | 01-29-2015 |
20150017654 | Absolute PCR Quantification - The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results. | 01-15-2015 |
20150017653 | Absolute PCR Quantification - The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results. | 01-15-2015 |
20150010947 | Domain Swapping Modules - Methods and systems for creating a genetic construct, a protein, and a polymer comprising a domain swapping module. A domain swapping module is a fusion protein in which a lever protein, which has a long amino (N) to carboxy (C) terminal distance, is inserted into a surface loop of an assembler protein, thereby stretching the assembler protein and splitting it into two fragments held apart by the lever so that they cannot rejoin. If the assembler protein is split at the proper location, the fragments will recombine with their respective counterparts from either one or more different—but similarly-split—assembler proteins. | 01-08-2015 |
20140364821 | SYSTEM AND METHOD FOR DRAINING FLUIDS - A system and/or a method of evacuating patient fluid from a subdural space of a patient. The system includes a flexible subdural drain having a plurality of apertures and a port in fluid communication with a valve. A reservoir containing a cleansing fluid is in fluid communication with the valve. An outlet in fluid communication with the valve. In a flush state, the valve is configured to establish fluid communication between the reservoir and the flexible subdural drain for evacuating the cleansing fluid from the reservoir. In a priming state, the valve is configured to close the fluid communication between the reservoir and the flexible subdural drain. In a drain state, the valve is configured to establish fluid communication between the flexible subdural drain and the outlet for evacuating the patient fluid via a siphoning effect through the outlet. | 12-11-2014 |
20140356894 | SITE-SPECIFIC ORTHOGONAL LABELING OF THE CARBOXY TERMINUS OF ALPHA-TUBULIN IN LIVE CELLS - A technique is provided to visualize microtubules in live cells that does not require genetic manipulation or microinjection. Moreover, this method also avoids perturbation of the endogenous microtubule network that occurs with taxol treatment. This technique exploits tyrosination and detyrosination of tubulin, a posttranslational modification cycle specific to the C-terminus of α-tubulin. Specifically, cells are grown in medium supplemented with a tyrosine derivative possessing a reactive functional group. The cellular enzyme tubulin tyrosine ligase attaches the unnatural amino acid to a single site on tubulin. Addition of fresh medium containing a suitably derivatized fluorophore then yields fluorescent tubulin, which incorporate into cellular microtubules. Importantly, the tubulin labeling approach demonstrated here does not detrimentally affect microtubule network or cell morphology. Thus we present a simple, robust labeling technique that allows microscopic analysis of microtubules in live cells. | 12-04-2014 |
20140350739 | SENSORS FOR POWER DISTRIBUTION NETWORK AND ELECTRICAL GRID MONITORING SYSTEM ASSOCIATED THEREWITH - A network of sensors is associated with a power distribution network. Sensors are positioned at each connecting line in the vicinity of each node of the power distribution network. The sensors regularly report the following measured data to the central processing unit: a geographical position of each sensor, direction of the energy flow relative to the nearest node; and value of RMS current synchronously measured over the entire network and averaged over chosen averaging period. The central processing unit includes an arrangement for receiving the measured data and using this data for constructing and updating a graph and a state of the power distribution network. | 11-27-2014 |
20140350720 | HOME MEDICATION MANAGER - A portable self medication management system and method comprising at least a plurality of receptacles, a scanner, a display screen, a housing for a compact electronic box, a compact electronic box and a processor to acquire medication information from a medication container, determine whether the medication information exists in a first database, if the medication information does not exist in the first database, associate the medication information with a location information comprising a receptacle and store the medication information and the location information in the first database, indicate the location information, and confirm placement of the medication container in the associated receptacle, notify a user to administer the medication held in the medication container, and request the user to scan the medication container of the notified medication, detect retrieval of an incorrect medication container from the plurality of receptacles, and issue a warning of the detection, and provide instructions for administering the medication. | 11-27-2014 |
20140349353 | ENGINEERED STRAIN OF ESCHERICHIA COLI FOR PRODUCTION OF POLY-R-3-HYDROXYALKANOATE POLYMERS WITH DEFINED MONOMER UNIT COMPOSITION AND METHODS BASED THEREON - Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one fatty acid substrate that is equal in carbon length to the prescribed or desired unit size of the PHA polymer to be produced. The prescribed unit size PHA that is produced is then isolated and/or purified. | 11-27-2014 |
20140336240 | METHOD OF TREATING HYPERLIPIDEMIA AND ATHEROSCLEROSIS WITH MIR-30C - This disclosure provides a novel role for microRNA (miR) regulation of lipid metabolism via the MTP pathway, leading to reductions in apoB secretion and blood lipid levels. MiR regulation of the MTP pathway is shown herein to reduce hyperlipidemia and atherosclerosis in vivo. Therefore, inhibition of MTP expression and activity by miR regulation is identified as a new therapeutic target for treatment of cardiovascular disease and conditions or diseases associated with cardiovascular disease such as hyperlipidemia, atherosclerosis, and metabolic syndrome. Treatment of cardiovascular disease and associated conditions or diseases with the novel MTP inhibitors of the invention, such as miR-30c homologs or miR-30c agonists, reduces MTP-associated lipid production without side effects that occur with other methods of MTP inhibition. | 11-13-2014 |
20140330153 | Selective Point of Care Nanoprobe Breath Analyzer - Disclosed is a medical diagnostic device for analyzing breath gases and/or skin emissions, including a highly sensitive sensing component for obtaining an emission concentration profile and a database of breath analysis profiles medical condition characteristics. | 11-06-2014 |
20140313342 | Photonic Bandgap Structures for Multispectral Imaging Devices - The invention discloses methods for making photonic bandgap structures and photonic bandgap structures made by those processes. In one embodiment, the photonic bandgap structure is flexible. In another photonic bandgap structure, the structure has a graded, periodic grating. One embodiment of a method according to the present invention comprises the steps of preparing a pre-polymer mixture, positioning that mixture between two slides, exposing the mixture to electromagnetic radiation, curing the mixture, and discarding at least one of the slides. In another embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a prism. In one embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a lens. | 10-23-2014 |
20140303525 | METHOD AND DEVICE FOR NON-INVASIVE ACOUSTIC STIMULATION OF STEM CELLS AND PROGENITOR CELLS IN A PATIENT - The present invention provides a method for non-invasive acoustic stimulation of stem cells and/or progenitor cells in a patient. The invention also provides a device for non-invasive stimulation of stem cells and/or progenitor cells in the patient by generating and delivering acoustic waves of a suitable frequency and intensity to the stem cells and/or progenitor cells. The method and device of the present invention is useful in enhancing regeneration of bones and other tissues, such as cartilages, muscles, and nerve tissues, in a patient, for treatment of conditions such as bone loss or fracture. | 10-09-2014 |
20140303226 | KCNQ CHANNELS AS THERAPEUTIC TARGETS - The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP | 10-09-2014 |
20140295480 | METAL SULFIDE AND RARE-EARTH PHOSPHATE NANOSTRUCTURES AND METHODS OF MAKING SAME - The present invention provides a method of producing a crystalline metal sulfide nanostructure. The metal is a transitional metal or a Group IV metal. In the method, a porous membrane is placed between a metal precursor solution and a sulfur precursor solution. The metal cations of the metal precursor solution and sulfur ions of the sulfur precursor solution react, thereby producing a crystalline metal sulfide nanostructure. | 10-02-2014 |
20140290436 | SURFACTANTLESS BIMETALLIC NANOSTRUCTURES AND METHOD FOR SYNTHESIZING SAME - A bimetallic nanowire synthesis method is provided. The method includes adding first and second solutions into a vessel containing a porous template with the first solution containing first and second reagents added on one side of the porous template and the second solution added on an opposite side of the porous template. The first reagent includes a first salt of at least one of a transition metal, an actinide metal and a lanthanide metal. The second reagent includes a second salt of at least one of a transition metal, an actinide metal and a lanthanide metal. The second solution contains a reducing agent. | 10-02-2014 |
20140287943 | ASSAY FOR SHIP1 EXPRESSION, ACTIVITY AND SEQUENCE ALTERATIONS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE RISK - The present disclosure is directed to detecting colon disorders by measuring the expression of SHIP1 in a sample of PBMCs. One method includes the following steps, obtaining a sample including peripheral blood mononuclear cells (PBMCs) from a subject and determining whether SHIP1 is underexpressed in the PBMCs or lacks normal enzymatic activity. The present disclosure is also directed to a method of determining the expression of SHIP1 protein expression and SHIP1 enzyme activity in PBMCs. This method includes the following steps, obtaining a sample comprising PBMCs from a subject and determining the amount of SHIP1 in the PBMCs. | 09-25-2014 |
20140275271 | NOVEL MODIFIED CURCUMINS AND THEIR USES - This invention provides a compound having the structure | 09-18-2014 |
20140273107 | HYDROLYSIS OF CELLULOSIC FINES IN PRIMARY CLARIFIED SLUDGE OF PAPER MILLS AND THE ADDITION OF A SURFACTANT TO INCREASE THE YIELD - A method for processing a stream of cellulosic fines containing inorganic particles, to increase a hydrolysis yield of polysaccharide degradation enzymes, such fines in a waste stream from a recycled packaging paper mill to produce a stream of fermentable sugars, comprising treating the fines with a surfactant which selectively binds to the inorganic particles and which reduces binding to the inorganic particles by the polysaccharide degradation enzymes, and degrading polysaccharides in the waste stream with the polysaccharide degradation enzymes. | 09-18-2014 |
20140273010 | ACID-CLEAVABLE AND CLICKABLE AFFINITY CAPTURE PROBE - The present disclosure relates to biological probes useful for detecting the presence of a target molecule. The biological probes are capable of forming complexes with the target molecule that are stable to reduction, oxidation and hydrolysis. | 09-18-2014 |
20140271584 | Methods and Compositions for Direct Reprogramming of Somatic Cells to Stem Cells, and Uses of these Cells - Presented herein are methods of generating an induced stem cell (iSC) from a somatic cell, by contacting the somatic cell with an induction factor that reprograms the somatic cell to generate an iSC. The induction factor can be a genetic construct or a fusion protein. Where the induction factor is a genetic construct, the construct bears one or more nucleotide sequences encoding one or more reprogramming elements selected from OCT4, SOX2, NANOG, and a Notch pathway molecule, or an active fragment or derivative thereof. The genetic construct can have a lentiviral or episomal vector backbone. The induction factor can also be a fusion protein, with the reprogramming element being a protein selected from OCT4, SOX2, NANOG, or a Notch pathway molecule, or an active fragment or derivative thereof. The fusion protein can be TAT protein or an active fragment or derivative thereof. | 09-18-2014 |
20140256060 | pH-INSENSITIVE GLUCOSE INDICATOR PROTEIN - The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof. | 09-11-2014 |
20140221320 | TOPICAL MINOCYCLINE OINTMENT FOR SUPPRESSION OF ALLERGIC SKIN RESPONSES - The method of the present application is directed towards a method for suppressing an allergic response in response to an allergic trigger. This method comprises the following steps; applying, topically, to an affected area an effective amount of a minocycline composition so that the minocycline composition contacts the affected area for an effective amount of time and removing the minocycline composition from the affected area. | 08-07-2014 |
20140212945 | RNA TARGETING COMPOUNDS AND METHODS FOR MAKING AND USING SAME - Disclosed are RNA targeting compounds, methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed. | 07-31-2014 |
20140206838 | COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS - Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs. | 07-24-2014 |
20140206112 | METHOD FOR REDUCING CHARGE IN CRITICAL DIMENSION-SCANNING ELECTRON MICROSCOPE METROLOGY - Methods and compositions are provided for reducing or eliminating charge buildup during scanning electron microscopy (SEM) metrology of a critical dimension (CD) in a structure produced by lithography. An under layer is utilized that comprises silicon in the construction of the structure. When the lithography structure comprising the silicon-comprising under layer is scanned for CDs using SEM, the under layer reduces or eliminates charge buildup during SEM metrological observations. | 07-24-2014 |
20140205662 | SYSTEM AND METHOD FOR DIFFERENTIALLY TIMED LOCAL DELIVERY OF A COMBINATION PHARMACEUTICAL PREPARATION FOR ORAL THERAPY - The present invention is directed to a system and method for treating oral diseases in a subject. This method comprises the following steps; diagnosing the subject, and choosing one or a combination of medications, their dosing and desired time course and then delivering the medications to the desired site in the periodontal pocket by administering a plurality of microcapsules, capsules, the microcapsules comprising one or more pharmaceutical agent(s) that are released in a predetermined manner and in accordance with the pathophysiology of the targeted disease. | 07-24-2014 |
20140196037 | GANG MIGRATION OF VIRTUAL MACHINES USING CLUSTER-WIDE DEDUPLICATION - Datacenter clusters often employ live virtual machine (VM) migration to efficiently utilize cluster-wide resources. Gang migration refers to the simultaneous live migration of multiple VMs from one set of physical machines to another in response to events such as load spikes and imminent failures. Gang migration generates a large volume of network traffic and can overload the core network links and switches in a data center. The present technology reduces the network overhead of gang migration using global deduplication (GMGD). GMGD identifies and eliminates the retransmission of duplicate memory pages among VMs running on multiple physical machines in the cluster. A prototype GMGD reduces the network traffic on core links by up to 51% and the total migration time of VMs by up to 39% when compared to the default migration technique in QEMU/KVM, with reduced adverse performance impact on network-bound applications. | 07-10-2014 |
20140188780 | KNOWLEDGE DISCOVERY FROM CITATION NETWORKS - In a corpus of scientific articles such as a digital library, documents are connected by citations and one document plays two different roles in the corpus: document itself and a citation of other documents. A Bernoulli Process Topic (BPT) model is provided which models the corpus at two levels: document level and citation level. In the BPT model, each document has two different representations in the latent topic space associated with its roles. Moreover, the multi-level hierarchical structure of the citation network is captured by a generative process involving a Bernoulli process. The distribution parameters of the BPT model are estimated by a variational approximation approach. | 07-03-2014 |
20140182796 | PRODUCT AND PROCESSES FROM AN INTEGRATED FOREST BIOREFINERY - An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions. | 07-03-2014 |
20140179637 | METHODS AND COMPOUNDS TO INHIBIT ENVELOPED VIRUS RELEASE - A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus. | 06-26-2014 |
20140170689 | Modified Diguanylate Cyclase-Phosphodiesterase and Method for Enzymatic Production of Cyclic-diGMP - The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1. | 06-19-2014 |
20140161730 | MAGNETIC GRAPHENE-LIKE NANOPARTICLES OR GRAPHITIC NANO- OR MICROPARTICLES AND METHOD OF PRODUCTION AND USES THEREOF - A magnetic graphene-like nanoparticle or graphitic nano- or microparticle exhibits a high relaxivity, and is useful as a MRI contrast agent. A composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. Methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. Methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle. | 06-12-2014 |
20140159483 | APPARATUS AND METHOD FOR OPTIMAL PHASE BALANCING USING DYNAMIC PROGRAMMING WITH SPATIAL CONSIDERATION - Provided are an apparatus and method for load-balancing of a three-phase electric power distribution system having a multi-phase feeder, including obtaining topology information of the feeder identifying supply points for customer loads and feeder sections between the supply points, obtaining customer information that includes peak customer load at each of the points between each of the feeder sections, performing a phase balancing analysis, and recommending phase assignment at the customer load supply points. | 06-12-2014 |
20140148380 | MOLECULAR ROADBLOCKS FOR RpoN BINDING SITES - The present invention relates to, inter alia, a method for repressing transcription and/or gene expression from RpoN binding sites (or promoters) or cryptic promoters upstream of RpoN binding sites. The method comprises providing an agent that specifically and selectively binds to RpoN promoter sequences to inhibit or repress the expression of genes downstream of that promoter; and contacting the RpoN promoter with the agent. Agents for repressing transcription and/or gene expression from RpoN promoters are also provided. The agent can be a composition that binds specifically to the −24, −12, or −24/−12 site(s) for RpoN promoter interference. Synthetic peptides, vectors, and host cells are also provided. | 05-29-2014 |
20140147602 | Attachment of Conducting Graphene Electrode Layer to an Organic Polymer - A method of attaching reduced graphene oxide and/or graphene oxide to a polymer layer that includes: forming a polymer layer having a hydrophobic, exterior surface; subjecting the hydrophobic, exterior surface of the polymer layer to ultraviolet/ozone (UV/O | 05-29-2014 |
20140134439 | SOLVENT-LESS ADHESIVE BONDING - A method for solvent-less adhesive bonding is provided comprising depositing thin, functional, polymeric films on one or more substrates and bonding the substrates to each other or to other substrates. Depositing the polymeric films, including, for example, chemically reactive polymers and thermoplastics with adhesive qualities, may be accomplished using an initiated chemical vapor deposition technique compatible with a variety of monomers, including monomers with chemically functional moieties such as amine and epoxy groups. The technique allows for deposition of polymeric films on a wide variety of substrates/devices and provides an alternative for other coating/deposition methods that are incompatible with certain substrates/devices and/or do not provide adequate control over the resulting polymeric film. The provided method is advantageous in that it is applicable to fabrication of hybrid devices and is compatible with microfabrication technology, including that in clean-room settings. | 05-15-2014 |
20140122039 | PATTERN CHANGE DISCOVERY BETWEEN HIGH DIMENSIONAL DATA SETS - The general problem of pattern change discovery between high-dimensional data sets is addressed by considering the notion of the principal angles between the subspaces is introduced to measure the subspace difference between two high-dimensional data sets. Current methods either mainly focus on magnitude change detection of low-dimensional data sets or are under supervised frameworks. Principal angles bear a property to isolate subspace change from the magnitude change. To address the challenge of directly computing the principal angles, matrix factorization is used to serve as a statistical framework and develop the principle of the dominant subspace mapping to transfer the principal angle based detection to a matrix factorization problem. Matrix factorization can be naturally embedded into the likelihood ratio test based on the linear models. The method may be unsupervised and addresses the statistical significance of the pattern changes between high-dimensional data sets. | 05-01-2014 |
20140113941 | THIOLACTONE ANTIBIOTICS - This invention provides a compound having the structure | 04-24-2014 |
20140095821 | SYSTEM AND METHOD FOR SECURITY AND PRIVACY AWARE VIRTUAL MACHINE CHECKPOINTING - A checkpointing method for creating a file representing a restorable state of a virtual machine in a computing system, comprising identifying processes executing within the virtual machine that may store confidential data, and marking memory pages and files that potentially contain data stored by the identified processes; or providing an application programming interface for marking memory regions and files within the virtual machine that contain confidential data stored by processes; and creating a checkpoint file, by capturing memory pages and files representing a current state of the computing system, which excludes information from all of the marked memory pages and files. | 04-03-2014 |
20140067424 | AUTOMATED IDENTIFICATION AND DOCUMENTATION OF CO-MORBIDITIES FROM PATIENTS ELECTRONIC HEALTH RECORD IN THE EMERGENCY ROOM - An inventive system and method for identifying and documenting co-morbidities is provided. The method can include selecting co-morbidity-related clinical data in accordance with one or more rules, said clinical data selected for a patient from the history data of the patient, pushing the selected clinical data to a display on a display device, displaying the selected clinical data on the display device along with the one or more rules, analyzing the displayed selected clinical data in accordance with the displayed one or more rules, validating the displayed selected data and storing the validated data. In one aspect, the method can further comprise sending the validated data to billing and/or printing the validated data. In one aspect, the clinical data can comprise one or more of laboratory data, EKG data, Echo data and radiology data. | 03-06-2014 |
20140057857 | Cross-Linked Peptides and Proteins, Methods of Making Same, and Uses Thereof - Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide. | 02-27-2014 |
20140054963 | ELECTRICAL POWER REGULATING AND MONITORING SYSTEMS AND OUTLET SYSTEMS THEREFOR - A system includes a plurality of outlet systems receivable in respective electrical boxes in a building and connected via electrical wires to an electric power supply. The plurality of outlet systems include at least one electrical receptacle connectable to an electrical appliance, a computing unit operable to monitor the electrical appliance, a switch for interrupting electrical power to the electrical appliance in response to the computing unit. The at least one electrical receptacle, the computing unit, and the switch are configured to be receivable within and connectable to the electrical box and covered by a cover plate having at least one opening for accessing the at least one electrical receptacle. A network device is operable for communicating with the plurality of outlet systems and for communicating with a global communications network. | 02-27-2014 |
20140045977 | NOVEL IONIC LIQUIDS, FUNCTIONALIZED PARTICULATES, AND FLUOROPOLYMER COMPOSITES - The present invention relates to (i) novel fluoroionic compounds capable of dispersing particulate filler compositions into a fluoropolymer; (ii) novel particulate compositions in which particulates are surface-functionalized with a fluoroionic compound; (iii) fluoropolymer composite materials containing the surface-functionalized particulates of (ii) incorporated into a fluoropolymer; (iv) crosslinked versions of (iii); v) methods for producing the crosslinked material of (iv); and (vi) articles of manufacture containing the compositions (iii) and (iv). | 02-13-2014 |
20140021067 | LOW CONCENTRATION AMMONIA NANOSENSOR - An electrochemical sensor for sensing a gaseous analyte includes a substrate having at least two electrodes disposed thereon, and a carbon nanotube-polyaniline (CNT/PANI) film disposed on the substrate and in contact with at least two electrodes. The CNT/PANI film includes carbon nanotubes coated with a thin layer of polyaniline. The thickness of the polyaniline coating is such that electron transport can occur along and/or between the carbon nanotubes. | 01-23-2014 |
20130295540 | Method and System for Minimally-Invasive Surgery Training Using Tracking Data - A system and method for training a person in minimally-invasive surgery (“MIS”) utilizing a video of the MIS. The system comprises a processor, a display, and a first interaction device. The processor programmed to receive the video and to obtain tracking data. The tracking data may correspond to the motion of a tool controller. The tracking data may correspond to motion of a first surgical tool in the video. The processor programmed to calculate motion of the first interaction device corresponding to the tracking data, to display the video, and to cause the first interaction device to move according to the calculated motion. The method comprises receiving the video, obtaining the tracking data, calculating a motion of a first interaction device corresponding to the tracking data, displaying the video, and causing the first interaction device to move according to the calculated motion. | 11-07-2013 |
20130289100 | SUBUNIT-SELECTIVE NUCLEIC ACID INHIBITORS OF GLUTAMATE RECEPTORS - Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Q | 10-31-2013 |
20130288214 | Method and System for Automatic Tool Position Determination for Minimally-Invasive Surgery Training - The present invention may be embodied as a method of minimally-invasive surgery (“MIS”) training using a video of an MIS comprising the steps of providing a processor, a display, and a first input device. The method comprises the step of processing the video using the processor to determine a location of the first surgical tool in each of the frames, determining whether the configuration of the first input device substantially corresponds to the location of the first surgical tool in each frame of the video while the video is displayed. The present invention may be embodied as a system for MIS training. The system comprises a processor, a communication device, and a first input device in communication with the processor. The processor is programmed perform any or all of the described disclosed methods. | 10-31-2013 |
20130238251 | METHOD AND SYSTEM FOR DETECTING DISCRIMINATORY DATA PATTERNS IN MULTIPLE SETS OF DATA - A comprehensive analysis procedure for analyzing and comparing multiple sets of data to detect hidden discriminatory data patterns. The inventive procedure identifies a best subset of markers for optimal discrimination between two or more sets of data. A point-wise test on two or more sets of data is performed to calculate test statistic values and to generate a statgram, a two- or higher-dimensional map of the test statistic values along the range of data. A threshold is then determined for isolating critical regions of the statgram at each significance level to provide candidate markers. A subset of markers from the candidate markers is then selected to discriminate among the sets of data. The two or more sets of data are classified using the subset of markers. | 09-12-2013 |
20130158105 | CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS - The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. | 06-20-2013 |
20130078661 | Compounds and Methods for FRET Based Measurement of Enzyme Activity - Provided are compositions and methods for Fluorescence/Forster Resonance Energy Transfer (FRET) analysis of cleavage of Von Willebrand Factor (VWF) polypeptides by the metalloprotease ADAMTS13. The polypeptides contain: i) a first fluorescent protein ii) a VWF amino acid sequence and iii) a second fluorescent protein. The VWF amino acid can contain any of a variety of amino acid substitutions. The method involves contacting a sample that contains ADAMTS13 and using FRET based measurements to determine ADAMTS13 cleavage of the recombinant polypeptide. | 03-28-2013 |