The Regents of the University of Colorado, a body Corporate Patent applications |
Patent application number | Title | Published |
20160060219 | INDOLINE ALKALOID COMPOUNDS - The present invention relates to indoline alkaloid compounds. In particular, indoline alkaloid compounds of the invention have antibacterial activity and/or are capable of resensitizing the susceptibility of methicillin-resistant | 03-03-2016 |
20160002285 | THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY - The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the compositions having low immunogenic potential and/or improved efficacy. The invention achieves these goals by evaluating therapeutic protein preparations for subvisible protein particulates, which can contribute significantly to the overall immunogenic potential of the protein preparation. Further, by maintaining the content of such subvisible protein particulates to below an immunogenic threshold level, the resulting pharmaceutical composition is less likely to result in a loss of tolerance (e.g., upon repeated administration), thereby improving both the safety and efficacy profile of the therapeutic. | 01-07-2016 |
20160000926 | CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS - The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS. | 01-07-2016 |
20150352149 | METHOD FOR STIMULATING RETINAL RESPONSE USING PHOTOACTIVE DEVICES - An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes. | 12-10-2015 |
20150290287 | THERAPEUTIC APPLICATIONS OF SMAD7 - The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systematically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis. | 10-15-2015 |
20150283520 | MIXED MATRIX POLYMER COMPOSITIONS - The present invention relates to a mixed-matrix composition comprising polymer having a fractional free volume of at least 0.1 and porous particles. | 10-08-2015 |
20150257927 | OPHTHALMIC SURGICAL DEVICE WITH ADJUSTABLE FILAMENT AND METHOD OF USE - An ophthalmic surgical device in accordance with various embodiments of the present disclosure comprises an elongate element and a filament. The device may further comprise one or more of a shaft, an actuator, an actuator handle, a shaft handle, a vent, and a filament stop. The device may be used to mechanically push objects, as in retinal detachment repair, gasp objects, as in the removal of a dislocated intraocular lens or an intraocular foreign body, aspirate fluid, and cut materials, such as intraocular fragments. | 09-17-2015 |
20150246057 | Metalloporphyrin Neurological Treatments - Methods and compositions for treating a subject suffering from exposure to a chemical threat agent are disclosed. | 09-03-2015 |
20150231237 | METHODS AND PRODUCTS FOR TREATING PROLIFERATIVE DISEASES - Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers | 08-20-2015 |
20150230981 | MODULAR INTRAOCULAR LENS DESIGNS, TOOLS AND METHODS - Modular IOL removal systems and methods that cut an optic portion of an intraocular in a single motion such to facilitate removal of the optic portion from an eye through an incision, for example a corneal incision, without increasing the size of the corneal incision. Various cutting tools having one or more blades may be utilized. The cut intraocular lens may have one continuous cut or be cut into multiple smaller pieces. The single cutting step may apply balanced forces and torque to avoid damaging the surrounding eye anatomy, reducing the risk of trauma. | 08-20-2015 |
20150225442 | EXOCYLIC NITROGEN ATOM PROTECTED NUCLEOSIDE AND METHOD FOR PRODUCING AND USING THE SAME - The present invention provides nucleosides comprising a sterically hindered silyl protecting group on the exocyclic nitrogen atom of the nucleobase, oligonucleotides comprising the same, and methods for producing the same. In particular, the silyl protecting group is a sufficiently sterically hindered such that it is stable to a various oligonucleotide synthesis procedures. | 08-13-2015 |
20150150942 | METHODS FOR EXTRACTING PLATELETS AND COMPOSITIONS OBTAINED THEREFROM - This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same. | 06-04-2015 |
20150147404 | LEDGF PEPTIDES AND FORMULATIONS THEREOF FOR TREATMENT OF DEGENERATIVE DISORDERS - LEDGF peptides with anti-protein aggregation activity and methods of use are provided. The LEDGF peptides disclosed herein demonstrate an ability to treat degenerative diseases and diseases with various cellular stresses including oxidative stress and protein-aggregation stress. In addition, extended release formulations, including formulations suitable for ophthalmic administration are provided. | 05-28-2015 |
20150111756 | SUPERCONDUCTING CABLES AND METHODS OF MAKING THE SAME - Superconducting cables employ one or more superconducting tapes wound around a former. A compact superconducting cable is configured using a former having a small diameter, e.g., less than 10 millimeters. A flexible superconducting cable is configured with a former made of a flexible material. Superconducting tape conductors are wound around the former, with the superconducting layer in compression on the inside of the wind turns of the wind, to prevent irreversible damage to the superconductor. A layer of solder is on the superconducting tape(s) or solder sheaths are wound between tape conductors in each layer. The one or more solder layers or sheaths are melted to cause the solder to flow within the structure, to bond some or all of the superconducting tape conductors together and form a mechanically strong cable with an enhanced level of electrical connectivity between tapes in the cable. | 04-23-2015 |
20150093373 | TREATMENT OF PULMONARY VASCULAR REMODELING WITH NEPRILYSIN - The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming from the inventor's discovery that Neprilysin is expressed at reduced levels in disease tissues. | 04-02-2015 |
20150087703 | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISEASE - The present invention provides a method and composition for treating a neurodegenerative disease. In particular, the present invention provides a method and composition to increase DJ-1 gene expression or DJ-1 protein activity to treat a neurodegenerative disease. | 03-26-2015 |
20150087682 | Method for Treating Scleroderma - The present invention provides a method for treating scleroderma by administering a therapeutically effective amount of a toll like receptor 4 inhibitor to a subject in need of such a treatment. | 03-26-2015 |
20150038480 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME - The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same. | 02-05-2015 |
20150031100 | COMPOSITIONS AND METHODS FOR CHEMICAL REPORTER VECTORS - Embodiments of the present invention concerns methods and compositions for the construction of a series of vectors containing a chemical sensing module to assess the production of a chemical compound by a microorganism. | 01-29-2015 |
20150015930 | NANOPHONONIC METAMATERIALS - Nanophononic metamaterials and methods for reducing thermal conductivity in at least partially crystalline base material are provided, such as for thermoelectric energy conversion. In one implementation, a method for reducing thermal conductivity through an at least partially crystalline base material is provided. In another implementation, a nanophononic metamaterial structure is provided. The nanophononic metamaterial structure in this implementation includes: an at least partially crystalline base material configured to allow a plurality of phonons to move to provide thermal conduction through the base material; and at least one nanoscale locally resonant oscillator coupled to the at least partially crystalline base material. The at least one nanoscale locally resonant oscillator is configured to generate at least one vibration mode to interact with the plurality of phonons moving within the base material and slowing group velocities of at least a portion of the interacting phonons and reduce thermal conductivity through the base material. | 01-15-2015 |
20150010541 | Macrocyclic Compounds Useful as Inhibitors of Histone Deacetylases - The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. | 01-08-2015 |
20140378831 | MULTIFUNCTIONAL NANOMATERIALS FOR THE TREATMENT OF CANCER - The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared spectrum; 2) an up-conversion phosphor that absorbs infrared light and emits visible luminescence; and optionally 3) a biomolecule targeting moiety. The invention further relates to methods of detecting and treating cancer using the multifunctional nanomaterials of the invention. | 12-25-2014 |
20140370036 | COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTITRYPSIN FcFUSION MOLECULES - A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), | 12-18-2014 |
20140348859 | COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES - Compositions of and methods for making and using alpha-1 antitrypsin (AAT) fusion molecules or peptide derivatives thereof are disclosed. The compositions and methods relate to generating an AAT fusion molecule of use in pharmaceutically acceptable compositions to treat a subject in need of AAT therapy or treatment. Compositions and methods disclosed herein concern linking AAT or derivative thereof to an immune fragment. | 11-27-2014 |
20140343225 | HYDROGELS AND METHODS FOR PRODUCING AND USING THE SAME - The present invention relates to hydrogels and methods for producing and using the same. In particular, some embodiments of the invention relate to hydrogels and methods for patterning the same. | 11-20-2014 |
20140341899 | COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES - Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment. | 11-20-2014 |
20140326926 | Methods for Diagnosis and Intervention of Hepatic Disorders - The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function. | 11-06-2014 |
20140321483 | COMPACT OPTICAL FREQUENCY COMB SYSTEMS - Compact optical frequency sources are described. The comb source may include an intra-cavity optical element having a multi-material integrated structure with an electrically controllable active region. The active region may comprise a thin film. By way of example, the thin film and an insulating dielectric material disposed between two electrodes can provide for rapid loss modulation. In some embodiments the thin film may comprise graphene. In various embodiments of a frequency comb laser, rapid modulation of the CEO frequency can be implemented via electric modulation of the transmission or reflection loss of an additional optical element, which can be the saturable absorber itself. In another embodiment, the thin film can also be used as a saturable absorber in order to facilitate passive modelocking. In some implementations the optical element may be formed on a cleaved or polished end of an optical fiber. | 10-30-2014 |
20140315894 | ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME - The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same. | 10-23-2014 |
20140296157 | COMPOSITIONS AND METHODS FOR PREPARING A SUBJECT FOR ORGAN OR NON-ORGAN IMPLANTATION - Embodiments of the present invention illustrate methods of preventing transplantation rejection. In certain embodiments, a subject in need of an organ or non-organ transplantation can be pretreated with an AAT composition to reduce the incidence of transplantion rejection in the subject. Other embodiments include treating a subject with a composition including AAT before, during or after plastic surgery. | 10-02-2014 |
20140294914 | INTRAOCULAR ENCAPSULATION OF OXYGENIC BACTERIA - Exemplary embodiments comprise an implantable ophthalmic device comprising at least one shell encapsulating oxygenic bacteria and growth medium and designed to increase the oxygen partial pressure in an oxygen-deprived structure of or space within, an eye. Exemplary embodiments may be used therapeutically to treat ischemic retinopathies in situ and thereby prevent damage, for example, retinal damage. | 10-02-2014 |
20140242096 | COMPOSITIONS AND METHODS RELATED TO GRAFT VERSUS HOST DISEASE AND TREATMENTS THEREOF - Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In particular, the present invention relates to compositions and methods for inhibition of graft rejection and promotion of graft survival. Thus, the invention relates to modulation of cellular activities, including graft rejection, promotion of graft survival, graft versus host rejection and conditions commonly associated with graft rejection. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease and inducers of other alpha1-antitrypsin activities. | 08-28-2014 |
20140234310 | COMPOSITIONS AND METHODS FOR TREATMENT OF BACTERIAL AND MYCOBACTERIAL INFECTIONS - A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), | 08-21-2014 |
20140221966 | Kalman Filter Based On-Off Switch for Insulin Pump - Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied. | 08-07-2014 |
20140220145 | METHOD FOR STIMULATING RETINAL RESPONSE USING PHOTOACTIVE DEVICES - An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes. | 08-07-2014 |
20140209788 | SPECTRUM SPLITTING USING OPTICAL RECTENNAS - Systems and methods for an improved solar/infrared conversion efficiency using multiple rectennas, one for each band of the spectrum. Each rectenna is optimally efficient for each spectrum band. An antenna receives at least one of a visible or infrared spectrum. Rectifying circuits coupled to the antenna generate a current based on a portion of the spectrum received by the at least one antenna. Each rectenna operates efficiently using a different operating voltage. The operating voltages are based on the selected load resistor and the current-voltage characteristics for the diode of the rectifying circuit at the associated spectrum portion. | 07-31-2014 |
20140193155 | Microphotonic Coupled-Resonator Devices - An optical resonator supports three resonance modes and having third-order optical nonlinearity. One or more waveguides are coupled to the three resonant modes. A waveguide input port is more strongly coupled to the first resonant mode than to the second and third resonant modes. A waveguide output port is more strongly coupled to at least one of the second and third resonant modes than to the first resonant mode. An optical filter has at least two optical resonators. The optical filter provides a passband having at least two poles and a transmission zero positioned outside the two poles. An optical demultiplexer includes first optical filter coupled in series with a second optical filter. Both optical filters provide a passband having at least two poles and a zero positioned outside the two poles. The zero of the first filter is located within the passband of the second filter. | 07-10-2014 |
20140193115 | Method and Apparatus for Optical Waveguide-to-Semiconductor Coupling and Optical Vias for Monolithically Integrated Electronic and Photonic Circuits - An optical coupler has a waveguide coupled to a grating of multiple scattering units, each scattering unit having a first scattering element formed of a shape in a polysilicon gate layer and a second scattering element formed of a shape in a body silicon layer of a metal-oxide-semiconductor (MOS) integrated circuit (IC). The couplers may be used in a system having a coupler on each of a first and second IC, infrared light being formed into a beam passing between the couplers. Vias may be interposed in third ICs between the first and second ICs. The couplers may be configured with nonuniform width of scattering elements to produce Gaussian or focused beams. | 07-10-2014 |
20140179612 | Transferrin-Tumstatin Fusion Protein and Methods For Producing and Using the Same - The present invention provides recombinant proteins comprising transferrin that is linked to tumstatin or other antiangiogenic protein and methods for producing and using the same. The present invention also provides an expression system, a plasmid, and a cell that is capable of expressing such recombinant proteins and methods for producing and using the same. | 06-26-2014 |
20140178887 | MINIMALLY-INVASIVE MEASUREMENT OF ESOPHAGEAL INFLAMMATION - The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation. | 06-26-2014 |
20140170140 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROMYELITIS OPTICA - The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with standard NMO therapies such as immunosuppressives or plasmaphersis. | 06-19-2014 |
20140168603 | Systems And Methods For Creating Aberration-Corrected Gradient Index Lenses - Embodiments include methods, systems, and/or devices that may be used to create aberration-corrected gradient index lenses. In some embodiments, data related to aberration measurements is received. This data is processed and an inverse map is generated to compensate for the aberration measurements. An intensity pattern corresponding to the inverse map is then projected onto a blank lens (e.g., to locally polymerize a mobile monomer) to create an exposed lens with a gradient index to correct for the aberration measurement. For example, in some embodiments, the lens may be an intraocular lens and the data can be generated by using a wavefront sensor to measure aberrations (e.g., an optical phase profile to correct defocus or astigmatism) in a patient's eye. | 06-19-2014 |
20140155420 | INHIBITORS OF EYA2 - The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject. | 06-05-2014 |
20140154499 | Method and Membrane for Nanoporous, Bicontinuous Cubic Lyotropic Liquid Crystal Polymer Membranes that Enable Facile Film Processing and Pore Size Control - A method of forming a nanoporous membrane includes preparing a solution of a gemini Imidazolium Lyotropic Liquid Crystal (LLC) monomer, a polar low-volatility organic solvent, and a radical photo-initiator in a volatile organic solvent; solvent-casting the solution onto a porous material, evaporating the volatile organic solvent; heating such that the gemini imidazolium monomer forms a Q-phase material and photopolymerizing the imidazolium monomer by exposing the radical photo-initiator to UV light; and exchanging the polar low-volatility organic solvent. Also disclosed is a membrane composed of polymerized gemini imidazolium LLC monomers, and a thin-film composite membrane having the Q-phase material supported on a porous supporting membrane. | 06-05-2014 |
20140154307 | INHIBITION OF FACTOR B, THE ALTERNATIVE COMPLEMENT PATHWAY AND METHODS RELATED THERETO - Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway. | 06-05-2014 |
20140147875 | DISEASE SEVERITY INDEX FOR ASSESSMENT OF CHRONIC LIVER DISEASE AND METHOD FOR DIAGNOSIS OF THREE DISTINCT SUBTYPES OF PRIMARY SCLEROSING CHOLANGITIS - A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors. | 05-29-2014 |
20140147013 | DIRECT ECHO PARTICLE IMAGE VELOCIMETRY FLOW VECTOR MAPPING ON ULTRASOUND DICOM IMAGES - An Echo PIV analysis process, apparatus and algorithm are developed to reduce noise and analyze DICOM images representing a fluid flow of a plurality of particles. A plurality of DICOM images representing sequential image pairs of a plurality of particles is received. The plurality of DICOM sequential image pairs are grouped. The sequential image pairs are correlated to create N cross correlation maps. An average cross-correlation transformation is applied to each cross correlation map to create an image pair vector map for each image pair. A maximizing operation is applied to one or more of the N adjacent image pair vector maps to create a modified image pair vector map for the one or more of the N image pairs. The maps are combined to create a corresponding temporary vector map that are averaged to obtain a mean velocity vector field of the sequential image pairs. | 05-29-2014 |
20140121295 | SHAPE MEMORY POLYMER - A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation. | 05-01-2014 |
20140109246 | METHODS OF GENERATING XENOCHIMAERIC MICE WITH TUMOR AND HEMATOPOIETIC SYSTEM FROM THE SAME HETEROLOGOUS SPECIES - The present invention provides methods for the generation of xenochimaeric animals; for example, xenochimaeric mice, comprising bone marrow progenitor cells and tumors from a heterologous animal. In some aspects, the invention provides xenochimaeric mice bearing humanized bone marrow and human tumors. Such animals are a model system for the study of human tumor stroma, for drug discovery, and for the treatment of human cancers. | 04-17-2014 |
20140100183 | CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS - The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS. | 04-10-2014 |
20140094507 | MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF - The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula: | 04-03-2014 |
20140093476 | METHODS FOR TREATING PAIN - Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions. | 04-03-2014 |
20140080730 | METHOD FOR PREDICTING SEVERITY OF ALLERGIC REACTION - The present invention provides methods for determining a likelihood of a degree of allergic reaction or a severity thereof using a threshold value rather than the binding activity number between the immunoglobulin of the subject and a test composition comprising a marker protein moiety of the allergy inducing material. In one particular embodiment of the invention, methods are provided for determining a likelihood of a degree of allergic reaction severity of a subject to peanuts using a threshold value of binding between immunoglobulin E (IgE) of the subject and Ara h 2 moiety and Ara h 6 moiety. | 03-20-2014 |
20140073572 | TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES - The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion. | 03-13-2014 |
20140066291 | MATERIALS AND METHODS FOR IMPROVING SELECTIVITY IN HETEROGENEOUS CATALYSTS AND PRODUCTS THEREOF - Methods for improving selectivity in heterogeneous catalysts, and products thereof, are disclosed. In exemplary embodiments, multifunctional oxygenates may be selectively converted to value-added products through reaction at a single functional position. Addition of a self-assembled monolayer (SAM), or SAM-like structures to a supported metal catalyst is also disclosed. | 03-06-2014 |
20140051744 | Markers For Assessing the Susceptibility of Cancer to Survivin-Targeting miRNA Treatment - The present invention relates to the use of miRNA treatment of survivin-positive cancer cells to increase sensitivity of cells to chemotherapy. | 02-20-2014 |
20140045768 | Tight Junction Protein Modulators and Uses Thereof - The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin. | 02-13-2014 |
20140039085 | DEGRADABLE THIOL-ENE POLYMERS - A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins. | 02-06-2014 |
20140038826 | COVALENTLY CROSS LINKED HYDROGELS AND METHODS OF MAKING AND USING SAME - A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers. | 02-06-2014 |
20140037708 | COMPOSITION FOR SPATIO AND/OR TEMPORAL RELEASE OF BIOACTIVE MATERIAL - The present invention provides a biocompatible composition that comprises a bioactive material and a method for using the same. In particular, the composition of the invention is useful for spatio and/or temporal release of the bioactive material. Specifically, the composition of the invention comprises at least one polymeric mixture layer comprising a plurality of biodegradable polymers. The polymeric mixture layer comprises a first biodegradable polymer and a second biodegradable polymer. The relative amount of the first biodegradable polymer or the second biodegradable polymer increases within the polymeric mixture layer in one direction, and the relative amount of the other biodegradable polymer decreases in the polymeric mixture layer in the same direction. The rate of degradation of the first biodegradable polymer is different from the rate of degradation of the second biodegradable polymer. In this manner, the composition allows spatio and/or temporal release of the bioactive material. | 02-06-2014 |
20130341175 | THERMAL TREATMENT SYSTEM AND METHOD - A improved solar biochar reactor, system including the reactor, and methods of forming and using the reactors and systems are disclosed. The methods and system as described herein provide sufficient solar energy to a biochar reactor to convert animal waste or other biomass to biochar in a relatively cost-effective manner. | 12-26-2013 |
20130337556 | METHODS FOR DELIVERING GENES - Methods of delivering transgenes to target cells using plasmids comprising viral inverted terminal repeat (ITR) sequences are described. Such plasmids are capable of directing sustained transgene expression in target cells in rats provided that at least one adeno-associated virus (AAV) ITR sequence is present in the plasmid, regardless of whether that ITR is located upstream or downstream of the transgene. In a particular embodiment, plasmids comprising one or more AAV ITR sequence and an IL-10 transgene are shown to be effective in sustained reversal of pain in an animal model of neuropathic pain. | 12-19-2013 |
20130323642 | Photoinduced Alkyne-Azide Click Reactions - The present invention includes a composition comprising an alkyne-based substrate, an azide-based substrate, a Cu(II) salt and a photoinducible reducing agent. The present invention further includes a method of immobilizing a chemical structure in a given pattern onto a section of the surface of a solid substrate, using the photoinducible Cu(I)-catalyzed azide-alkyne cycloaddition Click reaction. | 12-05-2013 |
20130315787 | NANOCRYSTALS AND METHODS AND USES THEREOF - Disclosed herein are (Ga | 11-28-2013 |
20130296416 | SELECTIVE INHIBITION OF BETA1- ADRENERGIC RECEPTORS FOR THE TREATMENT OF PEDIATRIC HEART FAILURE - Provided are methods of treating heart failure in children using B1-selective adrenergic receptor antagonists, alone or in combination with other agents, including B-2-selective adrenergic receptor agonists. | 11-07-2013 |
20130295590 | FOXA1 AS A MARKER FOR INVASIVE BLADDER CANCER - The present invention provides for a proteomic approach to predicting, diagnosing and staging invasive bladder cancer, and for predicting patient survival and therapeutic efficacy. More specifically, the target being analyzed for reduced expression is FOXA1, and optionally including analysis of increased FOXA2 expression. | 11-07-2013 |
20130289121 | PULMONARY DISEASE TREATMENT AND DIAGNOSIS BASED ON ARHGEF1 - Treatment and diagnostic methods are provided for pulmonary disease, including chronic obstructive pulmonary disease, Arhgef1, a leukocyte signaling molecule, functions normally to suppress integrin-mediated MMP production by alveolar macrophages. MMP9 production by fibronectin-stimulated monocytes and macrophages depends on autocrine thromboxane receptor signaling and this signaling pathway is attenuated by Arhgef1. Expression of ARHGEF1 by human peripheral blood monocytes varies between individuals and inversely correlates with fibronectin-mediated MMP9 production. Arhgef1 levels can function as a predictor for a pulmonary disease candidate and a thromboxane receptor antagonist can treat a pulmonary disease condition resulting from low Arhgef1 levels. | 10-31-2013 |
20130286521 | FAULT DETECTION, ISOLATION, LOCATION AND RECONNECTION SYSTEMS AND METHODS - In an example embodiment, systems and methods for detecting and handling faults in a DC bus system (“system”) can comprise detecting a fault in the segment, isolating the segment from the system, waiting for a period of time, connecting a probe power unit to the system at the isolated segment, and determining if a fault still exists on the isolated segment, wherein the determining is based on whether power is discharging from the probe power unit when connected to the system. The system can comprise one or more controllers and a probe power unit. | 10-31-2013 |
20130277890 | Dual-Cure Polymer Systems - The present invention includes compositions that are useful to prepare dual-cure shape memory polymer systems. The present invention further provides methods of generating a shape memory polymer, optical device, polymer pad with an imprint, or suture anchor system. | 10-24-2013 |
20130261295 | Highly Active Multidentate Catalysts for Efficient Alkyne Metathesis - The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogues. | 10-03-2013 |
20130253683 | Cut-Fold Shape Technology for Engineered Molded Fiber Boards - A three-dimensional engineered shaped fiber configuration is formed using determined structural requirements for a three-dimensional engineered shaped fiber configuration and ascertained properties of an engineered molded fiber fiberboard material. A first cut on a top surface and a second cut on a bottom surface of the fiberboard material are calculated. These calculations are based, at least in part, on the structural requirements properties of the fiberboard material. The first cut and the second cut each have a depth, a width, and a position. The first cut and the second cut have a spacing between them such that the flat piece of fiberboard material can be folded at a point located in the spacing between the first cut and second cut to position a first portion of the fiberboard material at a particular angle with respect to a second portion of the fiberboard material. | 09-26-2013 |
20130245397 | Statistical, Noninvasive Measurement of Intracranial Pressure - Tools and techniques for the rapid, continuous, invasive and/or noninvasive measurement, estimation, and/or prediction of a patient's intracranial pressure. In an aspect, some tools and techniques can predict the onset of conditions such as herniation and/or can recommend (and, in some cases, administer) a therapeutic treatment for the patient's condition. In another aspect, some techniques employ high speed software technology that enables active, long term learning from extremely large, continually changing datasets. In some cases, this technology utilizes feature extraction, state-of-the-art machine learning and/or statistical methods to autonomously build and apply relevant models in real-time. | 09-19-2013 |
20130244179 | Novel Thermoreversible Network Scaffolds and Methods of Preparing Same - The invention includes a novel light-activated polymerizable composition, wherein reversible crosslinks may be converted into irreversible crosslinks using a fully controllable physical and/or chemical process. The invention further includes methods of photofixing a light sensitive material or patterning an article comprising a light sensitive material. | 09-19-2013 |
20130218178 | MEDICAL FABRIC WITH INTEGRATED SHAPE MEMORY POLYMER - Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP-integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP-integrated fabric device. | 08-22-2013 |
20130207090 | Organic Photovotaics - The present disclosure is for improved organic semiconductors and improved organic photovoltaics. Liquid crystalline bent-core molecules in the B4 subphase of the present disclosure may be incorporated into improved organic semiconductors. Liquid crystalline bent-core molecules in the B4 subphase of the present disclosure may be incorporated into improved organic photovoltaics that may have improved quantum efficiencies over pre-existing organic photovoltaics. | 08-15-2013 |
20130197189 | Method For Synthesizing A Cyclic Multivalent Peptide Using A Thiol-Mediated Reaction - A method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydrl group on natural cysteine amino acids to participate in the thiol-mediated reactions. | 08-01-2013 |
20130195886 | Methods for Fructanase and Fructokinase Inhibition - Provided are methods and compositions method for inhibiting fructokinase activity within the gastrointestinal tract cell of a subject. The compositions and methods treat or prevent conditions associated with increased permeability and oxidative stress in the gastrointestinal tract of a subject. | 08-01-2013 |
20130195859 | Compositions and methods for modulating cardiac conditions - Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof. | 08-01-2013 |
20130190324 | TOPICAL OCULAR DRUG DELIVERY - The present invention provides compositions and methods for increasing the delivery (i.e., bioavailability) of a compound to an ocular cell. Such compositions and methods can be used to treat an ocular clinical condition. Typically, increased bioavailability or delivery of the compound to ocular cells is achieved by utilizing a membrane transporter. | 07-25-2013 |
20130172236 | METHODS FOR EXTRACTING PLATELETS AND COMPOSITIONS OBTAINED THEREFROM - This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same. | 07-04-2013 |
20130171236 | Prevention and Treatment of Ischemia-Reperfusion Injury and Related Conditions - Disclosed are lipids, annexin, and lipid-annexin complexes for use in the prevention and/or treatment of ischemia-reperfusion injury and reperfusion injury associated with a variety of diseases and conditions. Also disclosed are therapeutic targets and compositions for the prevention and treatment of ischemia-reperfusion injury and diseases and conditions associated with ischemia-reperfusion injury. | 07-04-2013 |
20130165949 | SOFT TISSUE COAPTOR AND DEVICE FOR DEPLOYING SAME - A soft tissue coaptor and a soft tissue coaptor deployment device are disclosed which deliver a soft tissue coaptor or clip to a desired location for tissue repair. The soft tissue coaptor and soft tissue coaptor deployment device have particular application in surgical and microsurgical settings such as cardiac, vascular, and ophthalmic surgery. | 06-27-2013 |
20130149734 | Multi-photon Tissue Imaging - A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition. | 06-13-2013 |
20130144384 | SOFT TISSUE GRAFT FIXATION - A surgical method for anterior cruciate ligament reconstruction includes creating a bone tunnel in a head of a femur of a patient. A connective tissue is inserted into the bone tunnel. A shape memory polymer plug is inserted into the bone tunnel. The plug has a first configuration for insertion and a second configuration for affixation that has a radially expanded dimension that presses the connective tissue against a side wall of the bone tunnel to affix the connective tissue in the bone tunnel. The plug changes from the first configuration to the second configuration in response to an activation temperature equal to or greater than a temperature of the femur. | 06-06-2013 |
20130129728 | ANTIBODIES TO THE C3D FRAGMENT OF COMPLEMENT COMPONENT 3 - The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both. The present invention also relates to methods and materials for modulating a host humoral immune response, especially reducing, inhibiting, or preventing a host humoral immune response. | 05-23-2013 |
20130123381 | Novel Resin Systems for Dental Restorative Materials and Methods Using Same - The invention includes a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. The system of the invention has enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems. | 05-16-2013 |
20130078245 | ANTIBODIES TO THE C3d FRAGMENT OF COMPLEMENT COMPONENT 3 - The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting prophylactic or therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both. The present invention also relates to methods and materials for modulating a host humoral immune response, especially reducing, inhibiting, or preventing a host humoral immune response. | 03-28-2013 |
20130065260 | Compositions, Methods and Uses for Simultaneous Assay of Thrombin and Plasmin Generation - Embodiments of the present invention report compositions and methods of analyzing thrombin and plasmin generation in a sample from a subject. In certain embodiments, the methods may comprise introducing at least one activator of coagulation and at least one activator of fibrinolysis to a sample and analyzing the sample for kinetic parameters related to thrombin and plasmin generation. In other embodiments, assays disclosed herein concern assessing net hemostatic balance of a subject for diagnostic and/or therapeutic applications. | 03-14-2013 |
20130056683 | COMPOSITIONS AND METHODS FOR PROMOTING FATTY ACID PRODUCTION IN PLANTS - The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels. | 03-07-2013 |
20130052220 | YEAST-HIV ANTIGEN COMPOSITIONS AND METHODS OF USING THE SAME - Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed. | 02-28-2013 |
20130035469 | Antimicrobial Peptides and Methods of Use - Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, specificity, resistance to degradation desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides result from structure-based rational design relating to antimicrobial peptide V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Some peptides contain one or more (or all) amino acids in the D configuration. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics. | 02-07-2013 |
20130004970 | METHODS FOR PREDICTION OF CLINICAL OUTCOME TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS BY CANCER PATIENTS - Disclosed are biomarkers, methods and assay kits for the identification of cancer patients who are predicted to benefit, or not to benefit, from the therapeutic administration of an epidermal growth factor receptor (EGFR) inhibitor. The biomarkers of the present invention include detection of EGFR and HER 2 gene amplification and polysomy, EGFR protein expression, EGFR mutations, phosphorylated Akt protein expression, and various combinations of such biomarkers, as well as the combination of these biomarkers with mutations in the tyrosine kinase domain of the EGFR gene. Increased EGFR gene copy number, increased HER2 gene copy number, increased EGFR protein expression, activated AKT protein expression (phosphorylated AKT) and EGFR mutations are all associated with better outcome for cancer patients treated with EGFR inhibitors. The invention provides a diagnostic paradigm based on each of these tests and combinations of these tests to select cancer patients who will benefit from EGFR inhibitor therapy, as well as a diagnostic paradigm to select cancer patients who will not benefit from EGFR inhibitor therapy. | 01-03-2013 |
20120330117 | Hemodynamic Reserve Monitor and Hemodialysis Control - Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index. | 12-27-2012 |
20120329161 | METHOD FOR ASSESSMENT OF HEPATIC FUNCTION AND PORTAL BLOOD FLOW - A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease. | 12-27-2012 |
20120323230 | LASER FUSION OF TISSUE LAYERS - A laser tissue fusion device is optimized for particular surgical applications to join tissue layers. The device has two opposed arms that engage and disengage to clamp and release layers of tissue therebetween. The distal end of the first arm is disposed opposite the distal end of the second arm. A laser energy source generates therapeutic laser energy is either integrated within the device is a separate unit. An energy pathway transmits the laser energy to the distal end of the first arm to deliver the laser energy to tissue layers clamped between the distal ends of the arms. An actuator decreases the separation distance between the distal ends of the arms to clamp the tissue layers. A switch activates the laser energy source upon engagement. The laser energy source delivers a burst of energy at a predetermined wavelength for a predetermined period of time sufficient to spot-weld the tissue. | 12-20-2012 |
20120317923 | STRUCTURAL INSULATED BUILDING PANEL - A structural insulated panel is composed of a structural member in a corrugated form and a cohering, insulating filler material. The structural member has a plurality of front surfaces spaced laterally apart from each other and a plurality of back surfaces spaced laterally apart from each other and spaced apart in depth from the front surfaces. The structural member has a plurality of chord panels which span between corresponding edges of respective pairs of the front surfaces and the back surfaces. Chase channels are formed between adjacent pairs of the cord panels and one of the front surfaces or one of the back surfaces. Each chord panel defines a plurality of apertures. The filler material fills the chase channels, binds to the front surfaces, back surfaces, and chord panels, and extends through the apertures in each of the cord panels to structurally connect the filler material in adjacent chase channels. | 12-20-2012 |
20120291991 | MICROCHANNEL EXPANDED HEAT EXCHANGER - A microchannel heat exchanger ( | 11-22-2012 |
20120289492 | METHODS OF TREATING MITOCHONDRIAL DISORDERS USING METALLOPORPHYRINS - Methods of treating a mitochondrial disorder including epilepsy, a neurological disorder, an inherited mitochondrial disease or inherited epilepsies, a pediatric epilepsy, an encephalopathy or a pediatric movement disorder are provided, as well as compounds useful in the methods of the invention, such as metalloporphyrin compounds as disclosed herein. | 11-15-2012 |
20120280980 | SPATIAL AND SHAPE CHARACTERIZATION OF AN IMPLANTED DEVICE WITHIN AN OBJECT - It is described a method for spatially characterizing a device positioned within an object, e.g. a patient's body, under examination that e.g. allows a clinician to easily assess the deployment state and position of the device. The method comprises the steps of acquiring ( | 11-08-2012 |
20120276061 | CD117+ Cells and Uses Thereof - The present invention provides compositions comprising CD117+ cells and methods for using the same in allograft. In some aspects of the invention, methods are provided for prolonging allograft survival in a subject by administering CD117+ cells. | 11-01-2012 |
20120264902 | Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP) - The present invention relates to methods, systems and compositions, including genetically modified microorganisms, adapted to exhibit increased tolerance to 3-hydroxypropionic acid (3-HP), particularly through alterations to interrelated metabolic pathways identified herein as the 3-HP toleragenic pathway complex (“3HPTGC”). In various embodiments these organisms are genetically modified so that an increased 3-HP tolerance is achieved. Also, genetic modifications may be made to provide at least one genetic modification to any of one or more 3-HP biosynthesis pathways in microorganisms comprising one or more genetic modifications of the 3HPTGC. | 10-18-2012 |
20120257197 | FOURIER DOMAIN SENSING - Methods and systems are disclosed of sensing an object. A first radiation is spatially modulated to generate a structured second radiation. The object is illuminated with the structured second radiation such that the object produces a third radiation in response. Apart from any spatially dependent delay, a time variation of the third radiation is spatially independent. With a single-element detector, a portion of the third radiation is detected from locations on the object simultaneously. At least one characteristic of a sinusoidal spatial Fourier-transform component of the object is estimated from a time-varying signal from the detected portion of the third radiation. | 10-11-2012 |
20120256338 | NEW RESIN SYSTEMS FOR DENTAL RESTORATIVE MATERIALS - The disclosure provides a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. Use of an off-stoichiometric ratio of thiol:ene functional groups in favor of excess thiols results in enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems. | 10-11-2012 |
20120232651 | SHAPE MEMORY POLYMER INTRAOCULAR LENSES - A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45. | 09-13-2012 |
20120232648 | IMPLANTATION OF SHAPE MEMORY POLYMER INTRAOCULAR DEVICES - A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45. | 09-13-2012 |
20120232010 | Compositions and Methods for Treating Bladder Cancer - The present invention provides methods and compositions for treating bladder cancer. In particular, the present invention provides a fusion protein comprising a toxin moiety that is linked to an epithelial growth factor (EGF) moiety. The toxin moiety and the EGF moiety can be linked optionally via a linker. Typically, the fusion protein is administered intravesically into the cancerous bladder. | 09-13-2012 |
20120215216 | ELECTROSURGICAL GENERATOR CONTROLLER FOR REGULATION OF ELECTROSURGICAL GENERATOR OUTPUT POWER - An electrosurgical generator may reduce unintended tissue damage by improving regulation of output power. The electrosurgical generator may control the power during a cycle, and react to a change in power if arcing occurs. Voltage sources, especially, demonstrate the tendency to have large, uncontrolled power excursions during normal electrosurgical use. The magnitude of the power excursions may be dependent on various factors. An exemplary electrosurgical generator control scheme reduces or minimizes the thermal spread by accurately supplying the specified power within a few cycles. Additionally, fast and accurate regulation provided by the constant voltage mode reduces or minimizes unintentional tissue charring. Thus, reduced thermal spread and charring should result in better surgical outcomes by reducing scarring and decreasing healing times. An electrosurgical generator controller may be configured to control both a DC-DC buck converter and a DC-AC boost inverter based in part on electrical parameters of the electrosurgical generator. | 08-23-2012 |
20120203160 | IMPLANTS FOR REDUCING INTRAOCULAR PRESSURE - The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open. | 08-09-2012 |
20120194823 | Spectral Phase Analysis For Precision Ranging - Interferometric path length measurements using frequency-domain interferometry form the basis of several measurement techniques, including optical frequency domain reflectometry (OFDR), optical coherence tomography (OCT), and frequency-modulated continuous wave (FMCW) radar and lidar. A phase-sensitive and self-referenced approach to frequency-domain interferometry yields absolute and relative path length measurements with axial precision orders of magnitude better than the transform-limited axial resolution of the system. | 08-02-2012 |
20120190729 | MIRNA INHIBITION OF SIX1 EXPRESSION - The invention provides a method of treating cancer in a subject comprising administering to said subject an miRNA that inhibits Six1. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject. | 07-26-2012 |
20120186446 | IMIDAZOLIUM-BASED ROOM-TEMPERATURE IONIC LIQUIDS, POLYMERS, MONOMERS, AND MEMBRANES INCORPORATING SAME - The present invention provides gels, solutions, films, membranes, compositions, and other materials containing polymerized and/or non-polymerized room-temperature ionic liquids (RTILs). These materials are useful in catalysis, gas separation and as antistatic agents. The RTILs are preferably imidazolium-based RTILs which are optionally substituted, such as with one or more hydroxyl groups. Optionally, the materials of the present invention are composite materials comprising both polymerized and non-polymerized RTILs. The RTIL polymer is formed from polymerized RTIL cations typically synthesized as monomers and polymerized in the presence of the non-polymerized RTIL cations to provide a solid composite material. The non-polymerized RTIL cations are not covalently bound to the cationic polymer but remain as free cations within the composite material able to associate with charged subunits of the polymer. These composite materials are useful in catalysis, gas separation, and antistatic applications. | 07-26-2012 |
20120178774 | TOLL-LIKE RECEPTOR MODULATORS AND USES THEREOF - The present invention provides a compound selected from the group consisting of: | 07-12-2012 |
20120172666 | ENDOSCOPE APPARATUS, ACTUATORS, AND METHODS THEREFOR - There is disclosed a MicroFlex Scope (MFS). The MFS is a dexterous endoscope providing access, direct visualization, tissue sampling, and treatment, of body lumens. In one embodiment, the distal end of the MFS is an ultra-flexible tip that comprises a plurality of thin, curved shape memory alloy (SMA) actuator elements attached to at least one structural skeleton, a coil spring skeleton or hinge structure. The SMA actuator elements in each structural skeleton segment are indirectly heated by a heater element and produce force in response to their temperature relative to specific thresholds. In configurations comprising a plurality of actuator elements, multiplexing/demultiplexing of heating currents and sensor voltages may be accomplished via a parallel bus and demulitplexing circuit. In this regard, a demultiplexing circuit using standard microelectronic fabrication techniques may be designed to achieve individual sensing and control over each actuator element. | 07-05-2012 |
20120172251 | METHODS AND COMPOSITIONS FOR DIAGNOSING HEART FAILURE - The present invention provides diagnostic and prognostic assays and kits for determining whether a heart failure patient will respond to a pharmacotherapy. Methods of the invention include determining the expression level of biomarkers that are differentially expressed in a heart failure patient that responds to a pharmacotherapy compared to a heart failure patient that does not respond to a pharmacotherapy. | 07-05-2012 |
20120149516 | HYBRID TRANSMISSION USING PLANETARY GEARSET FOR MULTIPLE SOURCES OF TORQUE FOR AERONAUTICAL VEHICLES - Provided are alternative hybrid transmission systems for marine, or two wheeled land vehicles, as well as propulsion systems and vehicles comprising such transmission systems, to improve various propulsion systems using a combination of at least two power sources with the option for simultaneous or alternating power input from two or more power sources, while providing desired characteristics or components. Such characteristics or components can include, but are not limited to: power, torque, acceleration, cruising speed or power, fuel efficiency, battery charging, endurance, power sizing, weight, capacity, efficiency, speed, mechanically and/or electrically added system requirements, design, fuel selection, functional design, structural design, lift to drag ratio, weight, and/or other desired characteristic or component. | 06-14-2012 |
20120135424 | MER DIAGNOSTIC AND THERAPEUTIC AGENTS - Mer diagnostic and therapeutic agents are disclosed. The agents are useful in the diagnosis and treatment of a variety of diseases including leukemia, lymphoma, and clotting disorders. | 05-31-2012 |
20120128724 | SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS - Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers. | 05-24-2012 |
20120116252 | SYSTEMS AND METHODS FOR DETECTING BODY ORIENTATION OR POSTURE - Systems and methods for detecting body orientation and/or posture are provided. At least one wave sensor may be configured to output waves and collect measurements data based upon the reflections of the output waves. At least one processor may be configured to receive measurements data from the at least one wave sensor and evaluate the received measurements data to determine a posture of a monitored subject. Based at least in part upon the determined posture, one or more suitable control actions may be implemented. | 05-10-2012 |
20120113513 | SELF-CLEANING OF OPTICAL SURFACES IN LOW-PRESSURE REACTIVE GAS ENVIRONMENTS IN ADVANCED OPTICAL SYSTEMS - Apparatus and methods for self-cleaning of optical elements in sealed environments over a wide range of operating optical frequencies prevent long-term power degradation by introducing low-pressure backfill of a reactive gas such as oxygen into a vacuum chamber containing the optical elements. The backfill pressure is preferably between 10 | 05-10-2012 |
20120101162 | METHODS AND COMPOSITIONS FOR INDUCING PHYSIOLOGICAL HYPERTROPHY - Methods and compositions are provided for inducing physiologic hypertrophy in a cell for treatment or prevention of a cardiovascular disease or condition. In certain embodiments methods and compositions involve an aquaporin 7inducer. | 04-26-2012 |
20120092632 | DIFFRACTION UNLIMITED PHOTOLITHOGRAPHY - Methods, devices, systems, and materials are disclosed for diffraction unlimited photofabrication. A method is provided where a photoresponsive material is illuminated with a first optical pattern at a first wavelength of light. The first wavelength of light alters a solubility of the photoresponsive organic material. The photoresponsive material is also illuminated with a second optical pattern at a second wavelength of light. The second wavelength of light hinders the ability of the first wavelength of light to alter the solubility of the photoresponsive organic material where the second optical pattern overlaps the first optical pattern. The photoresponsive organic material is then developed. | 04-19-2012 |
20120087936 | THERAPEUTIC AND PROPHYLACTIC VACCINE FOR THE TREATMENT AND PREVENTION OF PAPILLOMAVIRUS INFECTION - Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. Other embodiments also provide complexes comprising chimeras of papillomavirus L2 polypeptides non-covalently associated with papillomavirus L1 polypeptides, and GST fusions thereof. These compositions may be used to elicit immune responses in a patient to papillomavirus. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infection, especially papillomavirus infection and cervical cancers and warts associated therewith, made from compositions of this invention, are also disclosed. Nucleic acids and expression vectors coding for compositions are also disclosed. | 04-12-2012 |
20120070442 | METHODS AND COMPOSITIONS FOR TREATING CANCER - Provided herein are methods for identifying a cancer patient responsive to treatment with an EGFR tyrosine kinase inhibitor. One method comprises obtaining a biopsy from the patient and measuring the number of copies of miR-128 | 03-22-2012 |
20120070406 | THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY - The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the compositions having low immunogenic potential and/or improved efficacy. The invention achieves these goals by evaluating therapeutic protein preparations for subvisible protein particulates, which can contribute significantly to the overall immunogenic potential of the protein preparation. Further, by maintaining the content of such subvisible protein particulates to below an immunogenic threshold level, the resulting pharmaceutical composition is less likely to result in a loss of tolerance (e.g., upon repeated administration), thereby improving both the safety and efficacy profile of the therapeutic. | 03-22-2012 |
20120064009 | METHODS OF LEUKEMIA CELL DETECTION - Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time, determining whether a tissue in a subject contains a plurality of leukemia cells or a plurality progenitor leukemia cells, and determining whether a leukemia therapy administered to a subject is capable of decreasing the number of leukemia cells in a tissue of the subject. | 03-15-2012 |
20120046687 | Vascular Occlusion Devices - Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures ( | 02-23-2012 |
20120046225 | STABLE GLUCAGON FORMULATIONS FOR THE TREATMENT OF HYPOGLYCEMIA - The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via, e.g., the epidermal, dermal, or subcutaneous layer of the skin in a concentrated form of injectable glucagon that is dissolved in a pharmaceutically acceptable carrier. | 02-23-2012 |
20120016102 | NON-TOXIC BIOFILM INHIBITOR - The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of | 01-19-2012 |
20120016052 | Stress Relaxation in Crosslinked Polymers - The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. | 01-19-2012 |
20120006194 | HIGH FLUX SAPO-34 MEMBRANES FOR CO2/CH4 SEPARATION AND TEMPLATE REMOVAL METHOD - The present invention provides methods for making improved zeolite and crystalline silicoaluminophosphate (SAPO) membranes, in particular SAPO-34 membranes, on a porous support through improved removal of the organic structure-directing templating agent. A calcining step is performed in an oxygen free atmosphere, such as under a vacuum or inert gas, to remove the organic templating agent. By removing the templating agent in the absence of oxygen, the calcination step can remove a greater amount of the templating agent than comparable template removal steps conducted in the presence of oxygen and the calcination step can be conducted at significantly lower temperatures. The membranes of the present invention provide increased permeance while maintaining comparable selectivity for gas separations, particularly carbon dioxide (CO | 01-12-2012 |
20110282169 | Long Term Active Learning from Large Continually Changing Data Sets - Methods and systems are disclosed for autonomously building a predictive model of outcomes. A most-predictive set of signals S | 11-17-2011 |
20110281679 | HYBRID TRANSMISSION USING PLANETARY GEARSET FOR MULTIPLE SOURCES OF TORQUE FOR MARINE, OR TWO WHEELED LAND VEHICLES - Provided are alternative hybrid transmission systems for marine, or two wheeled land vehicles, as well as propulsion systems and vehicles comprising such transmission systems, to improve various propulsion systems using a combination of at least two power sources with the option for simultaneous or alternating power input from two or more power sources, while providing desired characteristics or components. Such characteristics or components can include, but are not limited to: power, torque, acceleration, cruising speed or power, fuel efficiency, battery charging, endurance, power sizing, weight, capacity, efficiency, speed, mechanically and/or electrically added system requirements, design, fuel selection, functional design, structural design, lift to drag ratio, weight, and/or other desired characteristic or component. | 11-17-2011 |
20110275648 | FLURBIPROFEN ANALOGS AND METHODS OF USE IN TREATING CANCER - Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers. | 11-10-2011 |
20110270153 | CELL STIMULATION USING QUANTUM DOTS - The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation of quantum dots to induce cell stimulation and/or function. | 11-03-2011 |
20110229497 | Modulating the Alternative Complement Pathway - Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins. | 09-22-2011 |
20110224775 | Stent Geometry - A non-expandable stent and a method for implanting the stent are provided. The stent includes a generally tubular body having a lumen defined therethrough. The body includes a proximal portion having a curved portion configured for placement proximal to a sphincter. The body further includes a distal portion having retaining member extending outward from a proximal end of the distal portion. The retaining member is configured for placement distal to the sphincter and for engagement of the sphincter. | 09-15-2011 |
20110214195 | Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity - The present invention provides methods for treating a clinical condition associated with lipoprotein lipase activity in the brain of a subject. | 09-01-2011 |
20110165143 | MODULATION OF CASPASES AND THERAPEUTICAL APPLICATIONS - The present invention provides caspase modulators in a wide variety of therapeutic applications. Some aspects of the present invention provide methods for using caspase modulators in treating tumor, promoting wound healing, and producing induced pluripotent stem cells. | 07-07-2011 |
20110130344 | TIGHT JUNCTION PROTEIN MODULATORS AND USES THEREOF - The invention provides tight junction protein modulators, compositions comprising the same, and uses thereof. In particular, the invention provides tight junction protein modulators that modulate the second extracellular loop of tight junction proteins, such as occludin or claudin. | 06-02-2011 |
20110112990 | Efficient Production of Peptides - The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production process of the invention may lead to advantages in yield, purity, and/or price. Methods of marketing peptides are also disclosed. | 05-12-2011 |
20110097406 | METHODS AND COMPOSITIONS FOR RETAINING ECM MATERIALS IN HYDROGELS - The present invention provides cell-laden and/or extracellular matrix material laden hydrogels for use in tissue engineering and methods for producing such hydrogels. In some particular embodiments, hydrogels comprise chondrocytes, which are typically encapsulated within the hydrogels. In many instances, such hydrogels are subjected to dynamic loading prior to being administered to a subject to treat a clinical condition that is helped by tissue engineering, including, but not limited to, cosmetic surgery such as craniofacial reconstruction surgery, and cartilage regeneration. | 04-28-2011 |
20110091482 | EXPRESSION OF KIR IN HUMAN CANCER CELLS AS A BIOMARKER FOR IMMUNO-ESCAPE AND CANCER METASTASIS - The present invention is based on the finding that the level of KIR expression in a cancer cell is significant with regard to tumor invasion and metastasis. Therefore, the present invention concerns methods and compositions for evaluating cancer in a patient based on KIR protein or mRNA expression. The invention also provides methods and compositions for treating cancer using a KIR inhibitor and methods of screening for KIR inhibitors. | 04-21-2011 |
20110087138 | NON-INVASIVE DEVICE FOR LOWERING INTRAOCULAR PRESSURE - The present invention provides devices and methods for non-invasively lowering intraocular pressure. In particular, some non-invasive intraocular pressure lowering devices of the invention comprise an oscillating element having a proximal end and a terminal probe. Typically, the terminal probe of said oscillating element comprises a substantially non-abrasive material that is adapted to be in contact with an ocular surface without causing any significant damage to the tissue and is shaped to conform to ocular surface at the limbal region. Devices also include an oscillating mechanism that is operatively connected to the proximal end of said oscillating tip such that when oscillating mechanism is in operation said oscillating tip moves axially without damaging ocular cells. Intraocular pressure lowering devices of the present invention are capable of non-invasively transmitting mechanical force to the tissue proximate to the limbal tissue. | 04-14-2011 |
20110063564 | LIQUID CRYSTAL COMPOSITE, CELL, DEVICE, AND METHOD THEREOF - The invention provides a liquid crystal (LC) composite, a LC cell, a LC device, and a method thereof. The LC composite comprises (i) a liquid crystal material, and (ii) a copolymer polymerized from LC monomers and non-LC-monomers; and the LC composite is mechanically stressed/sheared. The invention exhibits numerous merits such as high transmittance in visible and IR range, hysteresis free, and a simple fabrication process; and may be utilized in LC device applications such as adaptive optics e.g. beam steering devices and fast tip-tilt wavefront correctors; and general optical applications such as eye wears, compact cameras and compact telescopes. | 03-17-2011 |
20110054359 | Footwear-based body weight monitor and postural allocation, physical activity classification, and energy expenditure calculator - A footwear system for monitoring weight, posture allocation, physical activity classification, and energy expenditure calculation includes an accelerometer configured to obtain acceleration data indicative of movement of a user's foot or leg. The footwear system may also include a pressure sensing device mounted in an insole and configured to obtain pressure data indicative of pressure applied by a user's foot to the insole, as well as a transmitter communicatively coupled to both the accelerometer and the pressure sensing device and configured to transmit the acceleration and pressure data to a first processing device configured process the acceleration data and the pressure data to distinguish a first posture from a second posture different from the first posture and process the acceleration data and the pressure data to distinguish a first movement-based activity from a second movement-based activity different from the first movement-based activity. The footwear system may also include a second processing device communicatively coupled to the first processing device and configured to derive a second energy expenditure value. | 03-03-2011 |
20110015057 | MEMBRANES FOR HIGHLY SELECTIVE SEPARATIONS - The present invention provides modified molecular sieve membranes with improved CO | 01-20-2011 |
20110007772 | Phase-matched Generation of Coherent Soft and Hard X-rays Using IR Lasers - Phase-matched high-order harmonic generation of soft and hard X-rays is accomplished using infrared driving lasers in a high-pressure non-linear medium. The pressure of the non-linear medium is increased to multi-atmospheres and a mid-IR (or higher) laser device provides the driving pulse. Based on this scaling, also a general method for global optimization of the flux of phase-matched high-order harmonic generation at a desired wavelength is designed. | 01-13-2011 |
20100323348 | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process - The present invention provides methods and compositions for detecting and correcting errors in nucleic acid amplification processes, and methods for using the same. In particular, barcode amplification errors are detected and corrected such that integrity in sample assignment is maintained. The methods are compatible with high throughput sequencing techniques as some of the barcodes are based upon Hamming codes, thereby allowing self-correction for single bit errors. Some methods and compositions of the invention allow characterization (e.g., sequencing) of a plurality of nucleic acid samples simultaneously within a single sequencing reaction. | 12-23-2010 |
20100284992 | Phospholipase C and Method of Use - The present invention provides a method for reducing angiogenesis using a phospholipase C. | 11-11-2010 |
20100240965 | MINIMALLY-INVASIVE MEASUREMENT OF ESOPHAGEAL INFLAMMATION - The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation. | 09-23-2010 |
20100222253 | METHODS FOR EXTRACTING PLATELETS AND COMPOSITIONS OBTAINED THEREFROM - This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same. | 09-02-2010 |
20100221304 | Bionanocomposite Materials and Methods For Producing and Using the Same - The present invention provides bionanocomposite materials comprising at least two coaxial layers of bionanocomposites, and methods for producing and using the same. The bionanocomposite materials of the present invention comprise a core structure and a shell structure encapsulating the core structure, where one of the core structure or the shell structure comprises a porous biocompatible natural-derived material and the other comprises a biocompatible biomimetic nanostructure. | 09-02-2010 |
20100219067 | Electrochemical High Pressure Pump - The invention provides electrochemically-based methods and devices for producing fluid flow and/or changes in fluid pressure. In the methods and devices of the invention, current is passed through a divided electrochemical cell. Adjacent compartments of the cell are divided by a separator which comprises an ionically conducting separator. Each compartment includes an electrode and an electrolyte solution or ionic liquid. The electrolyte solution(s) or ionic liquid(s) and the ionically conducting separator are selected to obtain the desired relationship between the current through the cell and the fluid flowrate and/or change in fluid pressure. | 09-02-2010 |
20100192959 | SHAPE MEMORY POLYMER-BASED TRANSCERVICAL DEVICE FOR PERMANENT OR TEMPORARY STERILIZATION - Transcervical contraceptive devices (TCDs) are disclosed. The TCDs are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These SMPTCDs ( | 08-05-2010 |
20100185260 | METHOD FOR STIMULATING RETINAL RESPONSE USING PHOTOACTIVE DEVICES - An improved method for stimulating electrical activity in an eye is provided. The invention provides a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes. | 07-22-2010 |
20100152839 | Shape Memory Polymer Prosthetic Medical Device - A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device. | 06-17-2010 |
20100145648 | SYSTEM AND METHOD FOR CORRECTING SAMPLING ERRORS ASSOCIATED WITH RADIATION SOURCE TUNING RATE FLUCTUATIONS IN SWEPT-WAVELENGTH INTERFEROMETRY - The frequency-sampling method is widely used to accommodate nonlinear electromagnetic source tuning in swept-wavelength interferometric techniques, such as optical frequency domain reflectometry (OFDR) and swept-wavelength optical coherence tomography (OCT). Two sources of sampling errors are associated with the frequency-sampling method. One source of error is the limit of an underlying approximation for long interferometer path mismatches and fast electromagnetic source tuning rates. A second source of error is transmission delays in data acquisition hardware. Aspects of the invention relate to a method and system for correcting to sampling errors in swept-wavelength interferometry systems such that the two error sources correct sampling errors associated with the first radiation path and the second radiation path cancel to second order. | 06-10-2010 |
20100144678 | COMPOSITIONS AND METHODS FOR TREATING BONE CANCER - Small molecule bradykinin inhibitor bisphosphonate amide derivatives useful for inhibiting cancer growth and treating cancer residing in and around bone are disclosed. These compounds and pharmaceutical compositions containing these compounds are particularly useful for the treatment of prostate cancer bone metastases. | 06-10-2010 |
20100144007 | APPARATUS AND METHODS FOR LOADING SOFT MATERIALS - The present invention provides an apparatus for loading soft materials and methods for using the same. In some embodiments, the apparatus is a gearless mechanical loading apparatus which converts a rotational movement of one end of a first element into an arc of a circle movement of the other end of the first element; and converts the arc of a circle movement of the other end of the first element into a precision two-dimensional lateral movement of a second element. | 06-10-2010 |
20100105625 | Product and Methods for Diagnosis and Therapy for Cardiac and Skeletal Muscle Disorders - Disclosed are products and methods to promote myoblast activation and cardiac and skeletal muscle growth or regeneration, and to treat heart and skeletal muscle diseases, based on the identification of cellular processes affected by prelamin A processing. | 04-29-2010 |
20100099095 | METHODS FOR DETERMINING PROGNOSES AND THERAPEUTIC INTERVENTIONS FOR OVARIAN CARCINOMAS - Methods for determining the prognosis and therapeutic interventions for cancer and for utilizing the expression of the homeoprotein Six1 to determine the prognosis and therapeutic interventions for cancer, in particular for ovarian carcinomas. | 04-22-2010 |
20100055734 | Methods for Diagnosis and Intervention of Hepatic Disorders - The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function. | 03-04-2010 |
20100048693 | Treatment of COPD - The present invention provides methods for treating chronic obstructive pulmonary disease. In some embodiments of the invention, methods for treating COPD comprise administering PGI | 02-25-2010 |
20090316141 | FOURIER DOMAIN SENSING - Methods, systems, and apparatuses are provided for measuring one or more sinusoidal Fourier components of an object. A structured second radiation is generated by spatially modulating a first radiation. The structured second radiation illuminates the object, The structured second radiation is scaled and oriented relative to the object. The object produces a third radiation in response to the illuminating. A single-element detector detects a portion of the third radiation from multiple locations on the object substantially simultaneously for each spatial modulation of the first radiation and for each orientation of the second radiation. A time-varying signal is produced based on said detected portion of the third radiations. One or more characteristics of the one or more sinusoidal Fourier components of the object are estimated based on the time-varying signal. | 12-24-2009 |
20090286731 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF XEROSTOMIA - Methods for the treatment of xerostomia are described, hi particular, the present invention takes advantage of the inventors' observation that xerostomia is caused by induction of apoptosis, and can be inhibited by interfering with the cellular processes that trigger apoptosis in cells receiving chemo- and/or radiotherapy. | 11-19-2009 |
20090270528 | RESIN SYSTEMS FOR DENTAL RESTORATIVE MATERIALS - The disclosure provides a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. Use of an off-stoichiometric ratio of thiol:ene functional groups in favor of excess thiols results in enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems. | 10-29-2009 |
20080287367 | Non-Toxic Biofilm Inhibitor - The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of | 11-20-2008 |
20080216650 | Synthesis of Zeolites and Zeolite Membranes Using Multiple Structure Directing Agents - SAPO-34 membranes and methods for their preparation and use are described. The SAPO-34 membranes are prepared by contacting at least one surface of a porous membrane support with a synthesis gel comprising a first and a second templating agent. SAPO-34 crystals having a narrow size distribution were applied to the surface of the support prior to synthesis. A layer of SAPO-34 crystals is formed on at least one surface of the support. SAPO-34 membranes of the invention can have improved selectivity for certain gas mixtures, including mixtures of carbon dioxide and methane. | 09-11-2008 |