THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS Patent applications |
Patent application number | Title | Published |
20160137736 | ANTI-CTLA4, ANTI-GLUT2 PROTEIN FOR THE TREATMENT OF TYPE 1 DIABETES - The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic β-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic β-cells. | 05-19-2016 |
20160122348 | COMPOUNDS AND ANTI-TUMOR NQO1 SUBSTRATES - Compounds of Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compounds are useful for the management, treatment, control or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy. | 05-05-2016 |
20160115452 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 04-28-2016 |
20160111149 | ADAPTIVE RESISTIVE DEVICE AND METHODS THEREOF - A system that incorporates teachings of the subject disclosure may include, for example, a device including a nanoelectrode having a gap, and a resistive change material located in the gap, wherein an application of a voltage potential across first and second terminals of the nanoelectrode causes the resistive change material to modify at least one non-volatile memory state of the resistive change material. Additional embodiments are disclosed. | 04-21-2016 |
20160076038 | NANOPARTICLE MEDIATED DELIVERY OF siRNA - The invention provides multifunctional supramolecular self-assembled nanoparticles (SSNPs) comprising a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA. The nanoparticles can induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depleted systemic TNF-α production at an siRNA dose as low as 50 μg/kg, and protected the mice from lipopolysaccharide-induced hepatic injury. | 03-17-2016 |
20160074503 | Porcine Reproductive and Respiratory Syndrome Virus Compositions and Uses Thereof - Provided herein are embodiments relating to porcine reproductive and respiratory syndrome (PRRS) virus, compositions comprising the virus, and methods of using the virus. The virus may be used to immunize a mammal, including swine. Methods for generating an immune response against PRRS virus in swine by administering a composition comprising the virus are provided. | 03-17-2016 |
20160039857 | ANTIBACTERIAL COMPOUNDS TARGETING ISOPRENOID BIOSYNTHESIS - With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by interacting with binding pockets, thereby preventing enzyme function. Compounds described herein are also active against | 02-11-2016 |
20150344452 | PROCASPASE ACTIVATING COMPOUNDS - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds. | 12-03-2015 |
20150328848 | Method Of Making A Self-Healing Composite System - A self-healing composite system includes a solid polymeric matrix and a woven structure in the matrix. The woven structure includes a plurality of fibers, and a first plurality of microfluidic channels. The microfluidic channels include a first healing agent in the channels. The woven structure also may include a second plurality of microfluidic channels that include a second healing agent in the channels. | 11-19-2015 |
20150314006 | PARTICULATE DRUG DELIVERY METHODS - Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups. | 11-05-2015 |
20150307566 | VACCINE AND METHODS FOR DETECTING AND PREVENTING FILARIASIS - The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy. | 10-29-2015 |
20150302563 | Relighting Fragments for Insertion into Content - A fragment is relit for insertion into a target scene of an image by obtaining a fragment model for the fragment. A set of detail maps for the fragment model are generated, each of which encodes fine-scale shading effects from the surface detail of the fragment. A target scene model is obtained for the target scene, and the fragment model is inserted into the target scene model. The target scene model with inserted fragment model is rendered, and a composited target scene is generated. A modified target scene is generated by combining the composited target scene and the set of detail maps. Weights assigned to the different detail maps can be changed by the user, allowing the modified target scene to be readily altered without re-rendering the target scene model with the inserted fragment model. | 10-22-2015 |
20150283221 | ATTENUATED LISTERIA MONOCYTOGENES MUTANT AS A VACCINE VECTOR FOR THE DELIVERY OF EXOGENEOUS ANTIGENS - Vaccines and compositions containing an attenuated | 10-08-2015 |
20150274638 | COMPLEX AND STRUCTURALLY DIVERSE COMPOUNDS - The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp | 10-01-2015 |
20150268226 | MULTIMODAL MICROSCOPY FOR AUTOMATED HISTOLOGIC ANALYSIS OF PROSTATE CANCER - The present disclosure relates to methods of diagnosing prostate cancer using different imaging methods. For example, it is shown herein that combining a Fourier transform infrared (FT-IR) spectroscopic image with an optical image (such as a hematoxylin and eosin image) allows for automated detection of prostate cancer with high accuracy. | 09-24-2015 |
20150258211 | HYDROGELS FOR DELIVERY OF THERAPEUTIC POLYPEPTIDES - Disclosed herein is a hydrogel composition comprising a polymer covalently linked to glutathione (GSH). Also disclosed herein is a method for providing localized delivery of one or more agents in a subject suffering from a disease. The method comprises administering to the subject a GST/GSH affinity hydrogel comprising a therapeutically effective amount of the one or more agents. | 09-17-2015 |
20150246942 | ALIGNMENT OF NANOMATERIALS AND MICROMATERIALS - The present invention provides a method for preparing a nanoassembly that includes the step of reacting the assembly template with at least one nanomaterial to form the nanoassembly using a bifunctional linker. | 09-03-2015 |
20150246010 | HISTONE ACETYL TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM - The present invention relates to the reduction of a symptom of an alcohol withdrawal state comprising administering a modulator of histone acetylation. | 09-03-2015 |
20150240072 | Thermally Degradable Polymeric Fibers - A microvascular system includes a solid polymeric matrix and a woven structure in the matrix. The woven structure includes a plurality of fibers, and a plurality of microfluidic channels, where at least a portion of the microfluidic channels are interconnected. The microvascular system may be made by forming a composite that includes a solid polymeric matrix and a plurality of sacrificial fibers in the matrix, heating the composite to a temperature of from 100 to 250° C., maintaining the composite at a temperature of from 100 to 250° C. for a time sufficient to form degradants from the sacrificial fibers, and removing the degradants from the composite. The sacrificial fibers may include a polymeric fiber matrix including a poly(hydroxyalkanoate) and a metal selected from the group consisting of an alkali earth metal and a transition metal, in the fiber matrix, where the concentration of the metal in the fiber matrix is at least 0.1 wt %. | 08-27-2015 |
20150236220 | Small Water-soluble Quantum Dots - Water-soluble, stable fluorescent PEGylated alkanethiol-coated quantum dots are made by contacting quantum dots with PEGylated alkanethiol in a non-oxidative, water-immiscible organic reaction solvent under a non-oxidative gas, wherein the reaction solvent is in contact with an aqueous phase, at elevated temperature and time sufficient to coat the dots with the PEGylated alkanethiol, wherein resultant water-soluble, stable fluorescent PEGylated alkanethiol-coated dots enter the aqueous phase. | 08-20-2015 |
20150232529 | High Affinity TCR Proteins and Methods - T cell receptors (TCRs) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T cell receptor mutant coding sequence into yeast cells; inducing expression of the T cell receptor mutant coding sequence on the surface of yeast cells; and selecting those cells expressing T cell receptor mutants that have higher affinity for the peptide/MHC ligand than the wild type T cell receptor protein. The high affinity TCRs can be used in place of an antibody or single chain antibody. | 08-20-2015 |
20150228258 | LEADPIPE OR MOUTHPIPE SYSTEM FOR TROMBONE OR OTHER BRASS INSTRUMENT - A leadpipe for a musical instrument comprising: a sidewall defining an enclosed channel, the sidewall having an upstream end and a downstream end; wherein the sidewall is comprised of a plurality of sections including a first tapered section and at least one subsequent tapered section; wherein each of the sections extends longitudinally between the upstream end and the downstream end of the sidewall; wherein the first tapered section is disposed upstream of the at least one subsequent tapered sections; wherein the first tapered section and at least one subsequent tapered section of the sidewall each define a generally frustoconical cavity having an upstream inner diameter Df and a downstream inner diameter Ds; and wherein the downstream diameter of each of the tapered sections that defines a generally frustoconical cavity is larger than the upstream diameter. The leadpipe may produce greater intensity of overtones and improved sound quality. | 08-13-2015 |
20150210659 | PARTICULATE DRUG DELIVERY METHODS - The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells. | 07-30-2015 |
20150151268 | MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE - A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex. | 06-04-2015 |
20150141767 | Organ Mounted Electronics - Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current. | 05-21-2015 |
20150140283 | Branched Interconnected Microvascular Network in Polymers and Composites Using Sacrificial Polylactide Films, Sheets and Plates - A thermally degradable polymeric sheet, comprising: a poly(hydroxyalkanoate); and a metal selected from the group consisting of an alkali earth metal and a transition metal; where the volume fraction of the metal in the sheet is at least 0.1 vol %. | 05-21-2015 |
20150137930 | ROLLED-UP TRANSFORMER STRUCTURE FOR A RADIOFREQUENCY INTEGRATED CIRCUIT (RFIC) - A rolled-up transformer structure comprises a multilayer sheet having a rolled configuration comprising multiple turns about a longitudinal axis. The multilayer sheet comprises more than one conductive pattern layer on a strain-relieved layer, including a first conductive film and a second conductive film separated from the first conductive film in a thickness direction. The first conductive film comprises an even number of primary conductive strips, where each primary conductive strip has a length extending in the rolling direction, and the second conductive film comprises an even number of secondary conductive strips, where each secondary conductive strip has a length extending in the rolling direction. In the rolled configuration, turns of the primary conductive strips and turns of the secondary conductive strips wrap around the longitudinal axis. The primary conductive strips serve as a primary winding and the secondary conductive strips serve as a secondary winding of the rolled-up transformer structure. | 05-21-2015 |
20150137416 | Advanced Thermal Processing Techniques of "Sacrificial" Polylactic Acid - A method of making a sacrificial fiber, comprising: forming a molten sacrificial composition comprising a poly(hydroxyalkanoate) and a metal catalyst; extruding the molten sacrificial composition to form a sacrificial fiber comprising the poly(hydroxyalkanoate) and the metal catalyst, where the concentration of the metal catalyst in the sacrificial fiber is at least 0.1 wt %. | 05-21-2015 |
20150120311 | SYSTEM AND METHODS FOR EDUCATION THROUGH PATIENT SAFETY EVENT REPORTING - An education tool to assist any trainee or patient or family member, including a resident physician, in learning the skills necessary for proper patient safety event reporting including the identification, mitigation, and prevention of risks, hazards, and harms through a data-entry platform for preparing a report regarding a patient safety event. At all stages of the process, the trainee or resident physician or other reporter will receive feedback of event specific and aggregated patient safety information for purposes of trainee or other education. A national database to which events will be reported allows for aggregated sharing of the trainee or other reported occurrences. | 04-30-2015 |
20150099759 | POTENT ANTICANCER ACTIVITY VIA DUAL COMPOUND ACTIVATION - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds. | 04-09-2015 |
20150082263 | MERIT-BASED CHARACTERIZATION OF ASSERTIONS IN HARDWARE DESIGN VERIFICATION - A system is configured to generate assertions for verification of an integrated circuit hardware design expressed at a register transfer level (RTL) for variables of interest, each including an antecedent and a consequent. A relative importance score for the variables is determined by characterizing respective variables by a level of importance with respect to a target variable of the consequent. The relative importance scores may be combined to form a relative importance score of the assertion. A relative complexity score for the variable is determined by characterizing the variable by a level of understandability of the variable with respect to the target variable. The relative complexity scores are combined to form a relative complexity score of the assertion. The relative importance and complexity scores are combined to generate a rank score, which is used in ranking the assertion with respect to the RTL design for which the assertion was generated. | 03-19-2015 |
20150080405 | COMPOUNDS, COMPOSITIONS AND METHODS OF AGELASTATIN ALKALOIDS - The present invention, among other things, provides compounds, compositions and methods for treatment of cancer. In some embodiments, the present invention provides methods for treating blood cancer using agelastatin alkaloids. | 03-19-2015 |
20150050256 | Class I and II Lantibiotics from Geobacillus thermodenitrificans - The invention provides lantibiotics geobacillin I and geobacillin II from | 02-19-2015 |
20150031014 | DETECTING ANALYTES WITH A PH METER - Provided herein are sensors, kits that include such sensors, and methods for making and using such sensors. The sensors permit detection of a broad array of target molecules, such as nucleic acids (e.g., DNA and RNA), proteins, toxins, pathogens, cells, and metals, and can be used in combination with pH meters and pH paper. Thus, this disclosure provides a new methodology that allows pH meters and pH paper to be used for the detection of analytes other than pH. | 01-29-2015 |
20150024415 | DETECTION AND QUANTIFICATION OF ANALYTES BASED ON SIGNAL INDUCED BY ALKALINE PHOSPHATE - A general methodology for highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method and sensors take advantage of the ability of alkaline phosphatase (ALP) to convert glucose-1-phosphate to glucose, and the ability of PGMs to detect the generated glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents, for example to diagnose disease, are also provided. | 01-22-2015 |
20150010985 | METHODS AND COMPOSITIONS FOR IMPROVING SUGAR TRANSPORT, MIXED SUGAR FERMENTATION, AND PRODUCTION OF BIOFUELS - The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell. | 01-08-2015 |
20140374872 | Controlled Buckling Structures in Semiconductor Interconnects and Nanomembranes for Stretchable Electronics - In an aspect, the present invention provides stretchable, and optionally printable, components such as semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed, and related methods of making or tuning such stretchable components. Stretchable semiconductors and electronic circuits preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention are adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices. | 12-25-2014 |
20140373898 | OPTICAL SYSTEMS FABRICATED BY PRINTING-BASED ASSEMBLY - Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities. Optical systems of the present invention include devices and device arrays exhibiting a range of useful physical and mechanical properties including flexibility, shapeability, conformability and stretchablity. | 12-25-2014 |
20140361409 | Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components - Provided are methods for making a device or device component by providing a multi layer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components. | 12-11-2014 |
20140357584 | ARYL NAPHTHALIDE LIGNANS AS ANTI-HIV AGENTS - Provided herein are glycosidic aryl naphthalide lignans compounds, such as justiprocumin A isolated from the plant | 12-04-2014 |
20140353574 | FIELD EFFECT TRANSISTOR STRUCTURE COMPRISING A STACK OF VERTICALLY SEPARATED CHANNEL NANOWIRES - A field effect transistor structure comprises a source and a drain on a substrate, and a stack of n vertically separated channel nanowires isolated from the substrate and connecting the source and the drain, where n is an integer and 2≦n≦20. The channel nanowires collectively comprise at least two different thicknesses and/or at least two different dopant concentrations and/or at least two different semiconductor materials. | 12-04-2014 |
20140353406 | ATOMIZING-BASED CUTTING FLUID DELIVERY SYSTEM AND METHOD - An atomizing cutting fluid system. The system includes a common chamber terminating in a shaped droplet nozzle and including a nozzle section immediately behind the shaped droplet nozzle. An atomizer creates spray directly within the common chamber behind the nozzle section. A cutting fluid supply line provides cutting fluid to the atomizer. A high velocity gas nozzle within the nozzle section and behind the droplet nozzle is configured to provide a high velocity gas to entrain the flow of droplets. The nozzle section and droplet nozzle are configured to produce a fully developed droplets-gas flow at a predetermined distance from the droplet nozzle. In a cutting system, the spray system provides a uniform film for a macro or micro cutting operation at sufficient flow rates. | 12-04-2014 |
20140333925 | Optical Parametric Amplification of Weak Signals for Imaging Biological Tissue - Methods and apparatus for obtaining an image of light scattering biological tissue. A series of pulses of substantially monochromatic light of a first wavelength is generated and split into two parts, of which one part illuminates a scattering biological tissue at an intensity too low to damage the tissue, while a second part is upconverted to generate a pump beam. Sample light from the biological tissue, which may be scattered (or transmitted) light, or fluorescence, or Raman scattering, etc., is collected and directed from the scattering biological tissue, along with the pump beam, into a non-linear optical element, in a single pass or multiple passes. Parametrically amplified sample light emerging from the non-linear optical element is detected and analyzed or displayed. | 11-13-2014 |
20140323968 | MATERIALS, ELECTRONIC SYSTEMS AND MODES FOR ACTIVE AND PASSIVE TRANSIENCE - The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus. Materials, modeling tools, manufacturing approaches, device designs and system level embodiments of transient electronics are provided. | 10-30-2014 |
20140315915 | DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds. | 10-23-2014 |
20140314954 | MULTINOZZLE DEPOSITION SYSTEM FOR DIRECT WRITE APPLICATIONS - A multinozzle deposition system for direct write applications comprises a body including a first network of microchannels embedded therein, where the first network of microchannels extends from a parent microchannel through a series of furcations to a plurality of branching microchannels. The series consists of k generations with furcation number m where the /cth generation includes m | 10-23-2014 |
20140305900 | TRANSIENT ELECTRONIC DEVICES COMPRISING INORGANIC OR HYBRID INORGANIC AND ORGANIC SUBSTRATES AND ENCAPSULATES - The invention provides transient devices, including active and passive devices that physically, chemically and/or electrically transform upon application of at least one internal and/or external stimulus. Incorporation of degradable device components, degradable substrates and/or degradable encapsulating materials each having a programmable, controllable and/or selectable degradation rate provides a means of transforming the device. In some embodiments, for example, transient devices of the invention combine degradable high performance single crystalline inorganic materials with selectively removable substrates and/or encapsulants. | 10-16-2014 |
20140294792 | T-REG Cell Expansion - This invention relates to methods of expanding T regulatory cells through OX40L and Jagged-1 induced signaling. The methods can be used for treating autoimmune diseases. | 10-02-2014 |
20140288080 | THERAPEUTIC METHODS AND AGENTS FOR TREATING MYOTONIC DYSTROPHY - The invention provides compounds, compositions and methods for treating myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit replication of the nucleic acids. | 09-25-2014 |
20140287990 | COMPOSITIONS AND METHODS TO CONCURRENTLY TREAT AND/OR PREVENT MULTIPLE DISEASES WITH CUPREDOXINS - The present invention relates to compositions and methods to administer compositions comprising cupredoxin and/or cytochrome and/or variants, derivatives, truncations and structural equivalents of cupredoxin and cytochrome to treat and/or prevent two or more conditions in a mammalian cell. The invention also relates to compositions and methods to administer compositions comprising cupredoxin and/or cytochrome and/or variants, derivatives, truncations and structural equivalents of cupredoxin and cytochrome to concurrently treat and/or prevent two or more conditions in a patient such as HIV, cancer, malaria and inappropriate angiogenesis. | 09-25-2014 |
20140276619 | Extendable Intravenous Catheter - An intravenous catheter has a tip portion, an extendable portion and a proximal portion attached to a hub. The extendable portion has a refracted position and an extended position. A wire may be incorporated in the intravenous portion. The wire may have a receiver disposed in the tip portion. An extender tool is insertable and removable from the catheter. The extender is dimensioned to engage the receiver upon insertion into said catheter and lengthen the extendable portion of said catheter to said extended position when inserted. | 09-18-2014 |
20140275543 | STABILIZED COMPOSITIONS AND METHODS OF MANUFACTURE - A method for stabilization of potent alkanone-heterocyclic flavorants in dry powder form is provided. Coordination of alkanone-heterocyclic flavorants to transition metal salts results in the formation of stable crystalline complexes, which upon hydration release the free flavorant. Food and topping products containing the stabilized alkanone-heterocyclic flavorant are provided as are methods for stabilizing the alkanone-heterocyclic flavorant. | 09-18-2014 |
20140273029 | METHODS AND COMPOSITIONS FOR ENHANCING IMMUNOASSAYS - Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays. | 09-18-2014 |
20140270457 | STAIN-FREE HISTOPATHOLOGY BY CHEMICAL IMAGING - The present disclosure provides methods, systems, and computer-readable storage media that can be used to image an unstained sample. Traditionally histopathology and immunohistochemistry methods use stains or dyes in combination with microscopy (or other detection methods) to detect cells and cellular structures, such as proteins. However, the disclosed methods do not require the use of such stains and dyes. The disclosed methods can include obtaining a spectroscopic image (e.g., infrared (IR) imaging data) of the sample, analyzing the resulting spectroscopic image to reduce the dimensionality of the spectroscopic image, comparing the reduced spectroscopic image compared to a control (e.g., by using an appropriately trained algorithm) and generating an output computed stain image from the reduced IR spectra, thereby imaging the sample without the use of stains or dyes. | 09-18-2014 |
20140250550 | COMPOSITIONS AND METHODS FOR MODULATING ANTHOCYANIN ACCUMULATION AND PISTIL DEVELOPMENT - MdMYB3 nucleic acids and polypeptides are provided for use in modulating the accumulation of anthocyanins and flavonols as well as the length of styles and peduncles of transgenic flowers. | 09-04-2014 |
20140234862 | COMPOSITIONS AND METHODS FOR QUANTITATIVELY MONITORING LIPIDS - Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding. | 08-21-2014 |
20140232395 | METHOD AND SYSTEM FOR MULTI-SHOT SPIRAL MAGNETIC RESONANCE ELASTOGRAPHY PULSE SEQUENCE - Aspects of the subject disclosure may include, for example, a system that applies magnetic resonance elastography to a sample to obtain uncorrected k-space data where the magnetic resonance elastography utilizes a multi-shot spin-echo sequence with variable density spiral readout gradients, and adjusts the uncorrected k-space data to corrected k-space data by adjusting a k-space trajectory by shifting a center point for each shot to a new center point according to signal intensity and by adjusting a phase for each shot based on a phase offset that is determined according to the signal intensity. Other embodiments are disclosed. | 08-21-2014 |
20140232085 | GEAR-SHIFTING SYSTEM FOR MANUALLY PROPELLED WHEELCHAIRS - Apparatus for a manually-powered wheelchair comprising a frame and first and second wheel rotatably coupled to the frame. Each wheel includes a hand rim and a drive wheel. For each of the first and second wheels, a multiple speed transmission coupled to the wheel comprises a transmission output coupled to the drive wheel, a transmission input coupled to the hand rim, and at least two gears selectively coupling the transmission output to the transmission input. The transmission allows the drive wheel and the hand rim to rotate concentrically with one another but at different speeds. A selector is provided for selecting one of the at least two gears. A controller controls the selector to operate the transmission for the first and/or second wheel. | 08-21-2014 |
20140211521 | SCALABLE SINGLE-STAGE DIFFERENTIAL POWER CONVERTER - An embodiment of the invention is a scalable single stage differential power converter. The inverter can be implemented in signal, split and multi-phases. A multiphase converter can be achieved with only three modules. Integrated magnetics used in preferred embodiments of the invention mitigate the DC component of the steady-state dynamics and can be extended to AC ripple mitigation. Control architectures in preferred embodiments can mitigate higher order harmonics in steady state dynamics. Embodiments of the invention also provide scalability for voltage and current source topologies. | 07-31-2014 |
20140203707 | ELECTRON EMISSION DEVICE - Provided herein are electron emission devices and device components for optical, electronic and optoelectronic devices, including cantilever-based MEMS and NEMS instrumentation. Devices of certain aspects of the invention integrate a dielectric, pyroelectric, piezoelectric or ferroelectric film on the receiving surface of a substrate having an integrated actuator, such as a temperature controller or mechanical actuator, optionally in the form of a cantilever device having an integrated heater-thermometer. Also provided are methods of making and using electron emission devices for a range of applications including sensing and imaging technology. | 07-24-2014 |
20140197801 | SILICON-BASED ELECTRODE FOR A LITHIUM-ION CELL - A silicon-based electrode includes a silicon layer on a substrate, an electrically conductive layer overlying a top surface of the silicon layer, an optional polymer layer overlying the top surface of the electrically conducting layer, and a plurality of channels extending through the electrically conductive layer and the silicon layer to the substrate. The channels define sidewalls in the silicon layer. The electrically conductive layer and the optional polymer layer act to inhibit lithium ion intercalation through the top surface of the silicon layer during charging of a lithium-ion cell, and the lithium ion intercalation into the silicon layer occurs through the sidewalls that are defined by the channels. | 07-17-2014 |
20140193839 | Smartphone Biosensor - A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result. A wavelength-dispersive element may be used to disperse the optical output into spatially-separated wavelength components. The mobile computing device may be positioned relative to the wavelength-dispersive element such that different wavelength components are received at different locations on the image sensor. With the mobile computing device positioned in this way, the image sensor may be used to obtain one or more images that include the separated wavelength components of the optical output. A wavelength spectrum of the optical output may be determined from the one or more images, and the result may be determined from the wavelength spectrum. | 07-10-2014 |
20140187500 | COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES - The present application provides, among other things, compounds, compositions and methods for treating various diseases including cancer. | 07-03-2014 |
20140184135 | SYSTEM AND METHOD FOR COMPENSATING FOR HIGH FREQUENCY APPLICATION OF RIPPLE CORRELATION TO MINIMIZE POWER LOSSES IN INDUCTION MACHINES - A method for minimizing power losses in an alternating current (AC) machine is provided. The method includes determining a first rotor flux signal based on signals of voltage and current inputs to the AC machine, and extracting a ripple component of the rotor flux signal. The method further includes determining a power compensating value that corresponds to a stored energy value of the AC machine, determining a second rotor flux signal that serves to minimize power losses, and providing the second rotor flux signal to a power inverting unit that adjust accordingly the voltage and current input signals provided to the AC machine. | 07-03-2014 |
20140179617 | Cytotoxic Factors For Modulating Cell Death - Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer. | 06-26-2014 |
20140178887 | MINIMALLY-INVASIVE MEASUREMENT OF ESOPHAGEAL INFLAMMATION - The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation. | 06-26-2014 |
20140166232 | OPTIMIZED HEATING AND COOLING SYSTEM - An optimized heating and cooling system including a thermal mass, thermal energy transport conduits to deliver thermal energy to the thermal mass including one or more phase change materials (PCMs), at least one heat exchanger to exchange the thermal energy from a energy input into heat transfer fluid that is pumped through the thermal mass. The system also includes a controller in electronic communication with a temperature sensor, a throttle and a pump. A desired building temperature profile, a daily temperature forecast, the electricity rates, the thermal characteristics of the PCMs are entered into or obtained by the controller and the controller uses that information to optimize the energy use to avoid using the heating and cooling system during peak electricity demand time, or uses the rate structure to determine the operation sequence that results in the most efficient use of energy or least cost. | 06-19-2014 |
20140162519 | Partially Degradable Fibers And Microvascular Materials Formed From The Fibers - A partially degradable polymeric fiber includes a thermally degradable polymeric core and a coating surrounding at least a portion of the core. The thermally degradable polymeric core includes a polymeric matrix including a poly(hydroxy-alkanoate), and a metal selected from the group consisting of an alkali earth metal and a transition metal, in the core polymeric matrix. The concentration of the metal in the polymeric matrix is at least 0.1 wt %. The partially degradable polymeric fiber may be used to form a microvascular system containing one or more microfluidic channels. | 06-12-2014 |
20140162362 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 06-12-2014 |
20140161768 | PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS COMPOSITIONS AND USES THEREOF - Provided herein are embodiments relating to porcine reproductive and respiratory syndrome (PRRS) virus, compositions comprising the virus, and methods of using the virus. The virus may be used to immunize a mammal, including swine. Methods for generating an immune response against PRRS virus in swine by administering a composition comprising the virus are provided. | 06-12-2014 |
20140155314 | PEPTIDE COMPOSITIONS AND METHODS FOR TREATING LUNG INJURY, ASTHMA, ANAPHYLAXIS, ANGIOEDEMA, SYSTEMIC VASCULAR PERMEABILITY SYNDROMES, AND NASAL CONGESTION - Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for treating lung injury, including acute lung injury, which may include hyperpermeability of lung vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion. | 06-05-2014 |
20140135276 | LIPOPEPTIDE INHIBITORS OF RAS ONCOPROTEINS - The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal α-helix or hypervariable region (HVR) or a Ras protein, a nucleic acid encoding the peptide or peptidomimetic, and methods employing the same. | 05-15-2014 |
20140134404 | METHOD FOR FABRICATING DUAL DAMASCENE PROFILES USING SUB PIXEL-VOTING LITHOGRAPHY AND DEVICES MADE BY SAME - This invention provides processing steps, methods and materials strategies for making patterns of structures for integrated electronic devices and systems. Processing methods of the present invention are capable of making micro- and nano-scale structures, such as Dual Damascene profiles, recessed features and interconnect structures, having non-uniform cross-sectional geometries useful for establishing electrical contact between device components of an electronic device. The present invention provides device fabrication methods and processing strategies using sub pixel-voting lithographic patterning of a single layer of photoresist useful for fabricating and integrating multilevel interconnect structures for high performance electronic or opto-electronic devices, particularly useful for Very Large Scale Integrated (VLSI) and Ultra large Scale Integrated (ULSI) devices. Processing methods of the present invention are complementary to conventional microfabrication and nanofabrication methods for making integrated electronics, and can be effectively integrated into existing photolithographic, etching, and thin film deposition patterning systems, processes and infrastructure. | 05-15-2014 |
20140128408 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME - Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed. | 05-08-2014 |
20140111203 | REDUCING ARTIFACTS IN MAGNETIC RESONANCE IMAGES ACQUIRED USING PROPELLER ECHO PLANAR IMAGING - In PROPELLER utilizing EPI k-space sampling, phase errors arising primarily from eddy currents can considerably degrade image quality. The phase errors include spatially constant phase errors, spatially linear phase errors, and oblique phase errors. Methods to measure and correct for these phase errors are disclosed. Two or three reference scans are acquired, each reference scan being mutually orthogonal along the orthogonal physical gradient axes in a MRI system. A spatially constant phase error and a spatially linear phase error are determined from each of the reference scans for each relevant physical gradient axis. These phase errors can be used to predict the constant, linear, and oblique phase errors in each blade of an EPI PROPELLER k-space data set. With the known phase errors for each blade, constant, linear, and/or oblique phase correction is applied prior to or during PROPELLER image reconstruction, producing an image with substantially reduced artifacts. | 04-24-2014 |
20140100198 | ENZYME INHIBITING COMPOUNDS AND METHODS - The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe | 04-10-2014 |
20140096285 | SOYBEAN-BASED PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE AND METHODS FOR MAKING AND USING THE SAME - A transgenic soybean plant harboring an exogenous nucleic acid molecule encoding porcine reproductive and respiratory syndrome virus ORF7 immunogen and methods for using the same to induce an antibody response and prevent a porcine reproductive and respiratory syndrome virus infection are provided. | 04-03-2014 |
20140094615 | Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates - Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification. | 04-03-2014 |
20140093986 | Optically Monitoring and Controlling Nanoscale Topography - Methods and apparatus for method for characterizing a height profile of a scattering surface relative to a fiducial plane. The scattering surface, which may be an interface between distinct solid, liquid, gaseous or plasma phases, is illuminated with substantially spatially coherent light, and light scattered by the scattering surface is collected and dispersed, such as by a grating, into zeroth- and first-order beams. A spatial Fourier transform of the zeroth- and first-order beams is created, and one of the beams is low-pass filtered. The beams are interfered at a focal plane detector to generate an interferogram, which is transformed to retrieve a spatially resolved quantitative phase image and/or an amplitude image of the scattering surface. Imaging may be performed during an etching process, and may be used to adaptively control a photoetching process in a feedback loop. | 04-03-2014 |
20140088119 | Muscarinic Agonists as Enhancers of Working Memory and Cognitive Flexibility - Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine], or a pharmaceutically acceptable salt or hydrate thereof pharmaceutically acceptable salt or hydrate thereof. | 03-27-2014 |
20140085715 | Diffraction Phase Microscopy with White Light - A microscope and methods for obtaining a phase image of a substantially transparent specimen. Light collected from a specimen illuminated by a temporally incoherent source is diffracted into a first order and either the zeroth or first order is low-pass filtered in a Fourier transform plane before the orders are recombined at a focal plane detector. By low pass filtering the first order diffracted beam into a plurality of wavelengths, a spectrally- and spatially-resolved quantitative phase image of the specimen is obtained. | 03-27-2014 |
20140085713 | Phase Derivative Microscopy - Methods and a module for use with a microscope for enhancing image contrast in an image of a phase object. A transmission image of a specimen is formed in an image plane, of which a Fourier transform is generated in a Fourier plane. An amplitude filter is applied to the Fourier transform field, which is then transformed back to an image at a focal plane of a detector array. An image signal from the detector array is processed to generate a contrast-enhanced image of the specimen. | 03-27-2014 |
20140080789 | Method of Treating Diabetes, Glucose Intolerance, Insulin Resistance and/or Diabetes-Induced Diastolic Dysfunction - A method of treating, reversing, or ameliorating type 2 diabetes (DM) includes administering to a host in need thereof a therapeutically effective amount of a mitochondria-targeted antioxidant, such as mito-TEMPO (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride). | 03-20-2014 |
20140073785 | Methods for Forming Protected Organoboronic Acids - Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid. | 03-13-2014 |
20140073609 | Compositions and Methods Including Cell Death Inducers and Procaspase Activation - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3. | 03-13-2014 |
20140072540 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRABBE AND OTHER NEURODEGENERATIVE DISEASES - Provided are compositions and methods for the treatment of Krabbe and other neurodegenerative diseases associated with psychosine (and/or other storage material)—mediated axonal degeneration. Compositions and methods employ one or more inhibitor(s) of (1) a phosphotransferase activity of one or more kinase(s) such as CDK5, P38, jnk, src, CK2, PKC, GSK3α and β; (2) a phosphotransferase activity of one or more phosphatase(s) such as PP1 and PP2; (3) a caspase/calpain activity of one or more caspases such as caspase 3 and calpains such as calpain 1 and 2; and/or (4) a sodium/calcium exchange protein such as NCX1. Inhibitors include small molecules (e.g., the GSK3β inhibitor L803 and the NCX1 inhibitor flecainide) and siRNA molecules that downmodulate cellular levels of one or more mRNA, such as PP1 mRNA. Inhibitors disclosed can cross the blood-brain barrier and, thus, are available to the CNS and effective in reducing psychosine-mediated axonal degeneration. | 03-13-2014 |
20140071793 | SYSTEM AND METHOD FOR BROADBAND DOPPLER COMPENSATION - A Doppler compensation system includes a transmitter unit for transmitting a signal, wherein the transmitted signal being associated with an emission time-scale, a receiving unit for receiving a signal, wherein the received signal is associated with a receive time-scale that is not equivalent to the emission time-scale, and a Doppler compensating unit configured to estimate an inverse temporal distortion function, wherein the Doppler compensating unit implements the inverse temporal distortion function to estimate the transmitted signal. | 03-13-2014 |
20140057323 | ENHANCED CELLODEXTRIN METABOLISM - The present disclosure relates to host cells containing two or more of a recombinant cellodextrin transporter, a recombinant cellodextrin phosphorylase, a recombinant β-glucosidase, a recombinant phosphoglucomutase, or a recombinant hexokinase; and to methods of using such cells for degrading cellodextrin, for producing hydrocarbons or hydrocarbon derivatives from cellodextrin, and for reducing ATP consumption during glucose utilization. | 02-27-2014 |
20140056947 | VIRUS TRAPS - Specific applications of particles and particle agglomerates with semiconductor surfaces are provided. The particles and particle agglomerates display a high affinity for viral particles, and may be used therapeutically and/or prophylactically to treat or prevent viral infections. The particles and particle agglomerates may also be used to remove viral particles from a surface or fluid, e.g., as an absorbent in a filter, applied to surfaces to render them virostatic, and as tool to handle viral particles, e.g., for research, diagnostic, or decontamination purposes. | 02-27-2014 |
20140056820 | TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from | 02-27-2014 |
20140054651 | RELIABLE NANOFET BIOSENSOR PROCESS WITH HIGH-K DIELECTRIC - Provided are semiconductor field effect sensors including a high-k thin film gate dielectric. The semiconductor field effect sensors described herein exhibit high detection sensitivity and enhanced reliability when placed in contact with liquids. Also disclosed are semiconductor field effect sensors having optimized fluid gate electrode voltages and/or back gate electrode voltages for improved detection sensitivity. | 02-27-2014 |
20140050382 | Computational Adaptive Optics for Interferometric Synthetic Aperture Microscopy and Other Interferometric Imaging - Methods for correcting for aberrations in the image or three-dimensional reconstruction of a sampled region obtained by broadband interferometry. The sampled region is illuminated with a broadband beam of light, and light returned from the sample is detected, along with a reference beam, in order to derive an interference signal for pixels of a volume spanned by wavenumber and axes transverse to the beam propagation direction. An optimization procedure is performed with respect to a specified criterion so as to obtain an aberration-corrected image of at least one plane of the sampled region, either in a plane-specific manner or in a space-invariant manner throughout the sampled region. A filter function, which may be derived from the interference signal attendant to irradiating a sparsely distributed plurality of point scatterers, or otherwise, corrects for a detected aberrated point spread function. Methods of the present invention may be used for aberration correction in reading information from an optical data storage medium. | 02-20-2014 |
20140050241 | Semiconductor Device And Method For Producing Light And Laser Emission - A method for producing light emission, including the following steps: providing a transistor structure that includes a semiconductor base region disposed between a semiconductor emitter region and a semiconductor collector region; providing a cascade region between the base region and the collector region, the cascade region having a plurality of sequences of quantum size regions, the quantum size regions of the sequences varying, in the direction toward the collector region, from a relatively higher energy state to a relatively lower energy state; providing emitter, base and collector electrodes respectively coupled with the emitter, base, and collector regions; and applying electrical signals with respect to the emitter, base, and collector electrodes to cause and control light emission from the cascade region. | 02-20-2014 |
20140045863 | Muscarinic Agonists as Cognitive Enhancers - Methods of treating a mental condition by administering to a subject in need thereof an effective amount of compound CDD-102A, [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine] are described. | 02-13-2014 |
20140045755 | METHODS FOR TREATING SLEEP DISORDERS BY CHOLECYSTOKININ (CCK) RECEPTOR B ANTAGONISTS - The present invention relates to a method for preventing or ameliorating a sleep-related breathing disorder. The method involves the use of one or a combination of cholecystokinin (CCK) receptor antagonists. | 02-13-2014 |
20140042381 | STATE CHANGING DEVICE - A device that incorporates teachings of the present disclosure may include, for example, a memory array having a first array of nanotubes, a second array of nanotubes, and a state changing material located between the first and second array of nanotubes. Other embodiments are disclosed. | 02-13-2014 |
20140036950 | Light Emitting And Lasing Semiconductor Methods And Devices - A method for producing light emission from a two terminal semiconductor device with improved efficiency, includes the following steps: providing a layered semiconductor structure including a semiconductor drain region comprising at least one drain layer, a semiconductor base region disposed on the drain region and including at least one base layer, and a semiconductor emitter region disposed on a portion of the base region and comprising an emitter mesa that includes at least one emitter layer; providing, in the base region, at least one region exhibiting quantum size effects; providing a base/drain electrode having a first portion on an exposed surface of the base region and a further portion coupled with the drain region, and providing an emitter electrode on the surface of the emitter region; applying signals with respect to the base/drain and emitter electrodes to obtain light emission from the base region; and configuring the base/drain and emitter electrodes for substantial uniformity of voltage distribution in the region therebetween. | 02-06-2014 |
20140033565 | AID, METHODS OF USING THE SAME, AND KITS THEREOF - Disclosed herein is an aid for inducing a physiologically desirable movement. The aid comprises upper and lower surfaces, defining therebetween a thickness of the aid. The aid also comprises a plurality of protrusions extending from the upper surface of the aid and capable of engaging a body portion of a user for inducing discomfort in the body portion. Also disclosed herein are methods of using the aid to induce the physiologically desirable movement in a subject in need thereof and kits including one or more aids. | 02-06-2014 |
20140026714 | CONTINUOUS FLOW REACTOR AND METHOD FOR NANOPARTICLE SYNTHESIS - A continuous flow reactor for nanoparticle synthesis comprises a modular system including a plurality of interconnected tubular components for fluid flow therethrough including a first tubular inlet and a second tubular inlet connected to a three-way junction comprising a tubular mixer. A continuous flow method for nanoparticle synthesis comprises flowing a growth solution and a reaction-initiating solution into a mixing portion of a flow reactor to form a mixed solution; flowing the mixed solution through a holding portion of the flow reactor for a predetermined residence time to form a reacted solution comprising nanoparticles; and continuously removing the reacted solution from the flow reactor so as to achieve a throughput of nanoparticles of at least about 0.5 mg/min. | 01-30-2014 |
20140017457 | METHOD FOR PREPARING MICRO-PATTERNED SUPERHYDROPHOBIC/SUPERHYDROPHILIC COATINGS - Provided herein are methods and materials for the production of hydrophobic coatings, which may be thermally treated to produce binary hydrophobic-hydrophilic regions. | 01-16-2014 |
20140013854 | APPARATUS AND METHOD FOR IN SITU TESTING OF MICROSCALE AND NANOSCALE SAMPLES - According to example embodiments of the invention, a microscale testing stage comprises a frame having first and second opposing ends and first and second side beams, at least one deformable force sensor beam, a first longitudinal beam having a free end, a second longitudinal beam having a facing free end, a support structure, and a pair of slots disposed at each of the free ends. In certain embodiments, a layer of a conductive material defines first and second conductive paths and an open circuit that can be closed by the specimen across the gap. In other embodiments, the stage is formed of a high melting temperature material. | 01-16-2014 |
20140011811 | MYOSIN BINDING PROTEIN-C FOR USE IN METHODS RELATING TO DIASTOLIC HEART FAILURE - The invention provides methods relating to the diagnosis and treatment of diastolic heart failure, kits for diagnosing diastolic heart failure or diastolic dysfunction, and related systems, computer readable storage media, and methods implemented by a processor in a computer. | 01-09-2014 |
20140011014 | THREE-DIMENSIONAL (3D) POROUS DEVICE AND METHOD OF MAKING A 3D POROUS DEVICE - A method of making a three-dimensional porous device entails providing a substrate having a conductive pattern on a surface thereof, and depositing a colloidal solution comprising a plurality of microparticles onto the surface, where the microparticles assemble into a lattice structure. Interstices of the lattice structure are infiltrated with a conductive material, which propagates through the interstices in a direction away from the substrate to reach a predetermined thickness. The conductive material spans an area of the surface overlaid by the conductive pattern. The microparticles are removed to form voids in the conductive material, thereby forming a conductive porous structure having the predetermined thickness and a lateral size and shape defined by the conductive pattern. | 01-09-2014 |
20130345910 | DETECTOR FUNCTION AND SYSTEM FOR PREDICTING AIRFOIL STALL FROM CONTROL SURFACE MEASUREMENTS - Methods and apparatus for predicting airfoil stall for an aircraft having a control surface. Measurements of forces or moments acting upon an integrated span of the control surface are sensed over a period of time to provided unsteady data. The unsteady data is filtered to remove structural frequencies and input to at least one stall warning detection function, and an output is received. Each of the stall warning detection functions identifies an angle-of-attack that is approximately within a predetermined number of degrees of stall when the received output reaches a threshold. The received output is compared to the threshold to determine whether an angle-of-attack exists that is near stall. | 12-26-2013 |
20130337718 | ENCAPSULATED METAL MICROTIP MICROPLASMA DEVICE AND ARRAY FABRICATION METHODS - Methods of the invention can form microtip microplasma devices having the first and second metal microtips and metal oxide in a monolithic, unitary structure. Methods can form arrays that can be flexible, can be arranged in stacks, and can be formed into cylinders, for example, for gas and liquid processing devices, air filters and other applications. A preferred method of forming an array of microtip microplasma devices provides a metal mesh with an array of micro openings therein. Electrode areas of the metal mesh are masked leaving planned connecting metal oxide areas of the metal mesh unmasked. Planned connecting metal oxide areas are electrochemically etched to convert the planned connecting metal oxide areas to metal oxide that encapsulates opposing metal microtips therein. The mask is removed. The electrode areas are electrochemically etched to encapsulate the electrode areas in metal oxide. | 12-19-2013 |
20130337257 | HIGH SURFACE AREA CARBON OPALS AND INVERSE OPALS OBTAINED THEREFROM - A self-assembled carbon structure such as a carbon opal is disclosed herein. The structure is composed of hydrophilic carbon spheres oriented in a periodic colloidal crystal structure, wherein the carbon spheres have a porous surface, wherein the carbons spheres have an average particle diameter less than 3000 nm. Also disclosed is an inverse opal structure that includes a plurality of voids in the structural material. The voids are regularly arranged in an ordered periodic structure, the voids having a spherical shape. The inverse opal structure has a specific surface area greater than 100 m | 12-19-2013 |
20130335825 | Method of Manufacture of X-Ray Diffraction Gratings - Methods and apparatus for manufacturing an optical grating, and the optical grating manufactured thereby. A workpiece is secured to a carriage driven by a linear actuator. A tool is maintained in contact with the workpiece at either a constant force or a constant displacement normal to the surface of the workpiece while the carriage is translated. A plurality of grooves is ruled into the workpiece in this manner. | 12-19-2013 |
20130333094 | Appendage Mountable Electronic Devices COnformable to Surfaces - Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators. | 12-19-2013 |
20130320503 | METHODS AND DEVICES FOR FABRICATING AND ASSEMBLING PRINTABLE SEMICONDUCTOR ELEMENTS - The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations. | 12-05-2013 |
20130317223 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions - A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: | 11-28-2013 |
20130316437 | METHODS AND COMPOSITIONS FOR IMPROVING SUGAR TRANSPORT, MIXED SUGAR FERMENTATION, AND PRODUCTION OF BIOFUELS - The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell. | 11-28-2013 |
20130313452 | MICROFLUIDIC PRESSURE AMPLIFIER CIRCUITS AND ELECTROSTATIC GATES FOR PNEUMATIC MICROSYSTEMS - An electrostatic actuator is provide that can include a fluidic line, a first electrode, and a second electrode such that a gate chamber portion of the fluidic line is sandwiched between the first electrode and the second electrode. The electrostatic actuator can also include a pressure-balancing channel in fluid communication with the gate chamber portion where the first electrode is sandwiched between the pressure-balancing channel and the gate chamber portion. A pneumatic valve system is provided which includes an electrostatic gate and a fluidic channel fluidly separate from a fluidic control line. A pneumatic valve portion of the fluidic control line can be positioned relative to a portion of the fluidic channel such that expansion of the pneumatic valve portion restricts fluid flow through the fluidic channel. Methods of using an electrostatic actuator and a pneumatic valve system are also provided. | 11-28-2013 |
20130303941 | Method and Apparatus for Evaluating Dynamic Middle Ear Muscle Activity - Provided are methods and devices for evaluating dynamic middle ear muscle activity in a subject. A probe is provided having a speaker and a microphone in sound-wave communication with an eardrum associated with the middle ear muscle of the subject. A sound wave is generated from the speaker and transmitted to the eardrum. The sound wave that is reflected is detected and a reflected sound wave property measured. The input sound wave may be comb input to fully extend ossicle movement in all available vibratory modes, thereby providing maximum information as to dynamic middle ear muscle activity. | 11-14-2013 |
20130296989 | IMPLANTER FOR NERVE STIMULATION - The present invention is directed to an implanter for nerve stimulation. The implanter comprises a plurality of preformed stylets and a hollow needle. Each preformed stylet defines a butt end, a tip opposite the butt end, and a curved portion extending therebetween. The needle defines a first end configured to receive each preformed stylet, a second end opposite the first end, and a curved portion extending therebetween. The curved portion of the needle and the curved portion of the preformed stylets are of substantially congruent shapes such that the preformed stylets are interchangeably insertable into the needle. | 11-07-2013 |
20130296573 | System for Controlling the Reactivity of Boronic Acids - A protected organoboronic acid includes a boron having an sp | 11-07-2013 |
20130295631 | COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS - The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars. | 11-07-2013 |
20130295588 | COUNTING PARTICLES USING AN ELECTRICAL DIFFERENTIAL COUNTER - This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples. | 11-07-2013 |
20130289934 | ANGLE-BASED SPEED ESTIMATION OF ALTERNATING CURRENT MACHINES UTILIZING A MEDIAN FILTER - A computer-implemented method for estimating a rotor speed of an alternating current (AC) machine is provided. The method includes determining a stator flux signal based on signals of voltage and current inputs to the AC machine, and determining a rotor flux signal of the AC machine based on the determined stator flux signal. The method includes determining an electrical angle signal based on the determined rotor flux signal, and deriving an electrical frequency signal from the determined electrical angle signal. Subsequently, the method includes sampling the derived electrical frequency signal at a predetermined sampling rate, and storing a predetermined number of sample values. The method further includes evaluating a median value of the predetermined set of electrical frequency sample values, determining a slip frequency value of the AC machine, and determining the rotor speed of the AC machine by subtracting the slip frequency value from the electrical frequency median value. | 10-31-2013 |
20130285001 | METHODS FOR FORMING A NANOWIRE AND APPARATUS THEREOF - A system that incorporates teachings of the subject disclosure may include, for example, a method for depositing a first material that substantially covers a nanoheater, applying a signal to the nanoheater to remove a first portion of the first material covering the nanoheater to form a trench aligned with the nanoheater, depositing a second material in the trench, and removing a second portion of the first material and a portion of the second material to form a nanowire comprising a remaining portion of the second material covering the nanoheater along the trench. Additional embodiments are disclosed. | 10-31-2013 |
20130279245 | ADAPTIVE RESISTIVE DEVICE AND METHODS THEREOF - A system that incorporates teachings of the subject disclosure may include, for example, a device including a nanoelectrode having a gap, and a resistive change material located in the gap, wherein an application of a voltage potential across first and second terminals of the nanoelectrode causes the resistive change material to modify at least one non-volatile memory state of the resistive change material. Additional embodiments are disclosed. | 10-24-2013 |
20130276512 | Portable Gas Analyzer - A portable gas analyzer comprising an integrated micro-flame ionization detector (micro-FID), a micro-gas chromatograph (micro-GC), an electrolyzer, and a flame-shaped electrode are provided. The components of the portable gas analyzer can be integrated into a single “lunchbox” sized housing with all the peripherals required to operate the micro-GC/FID without an external power and gas supply. | 10-24-2013 |
20130274226 | SILICA NANOPARTICLE AGENT CONJUGATES - The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein. | 10-17-2013 |
20130274173 | STABLE HELICAL IONIC POLYPEPTIDES - The invention provides polymers comprising Formula I: | 10-17-2013 |
20130262455 | REAL TIME IMPLICIT USER MODELING FOR PERSONALIZED SEARCH - A method and apparatus for utilizing user behavior to immediately modify sets of search results so that the most relevant documents are moved to the top. In one embodiment of the invention, behavior data, which can come from virtually any activity, is used to infer the user's intent. The updated inferred implicit user model is then exploited immediately by re-ranking the set of matched documents to best reflect the information need of the user. The system updates the user model and immediately re-ranks documents at every opportunity in order to constantly provide the most optimal results. In another embodiment, the system determines, based on the similarity of results sets, if the current query belongs in the same information session as one or more previous queries. If so, the current query is expanded with additional keywords in order to improve the targeting of the results. | 10-03-2013 |
20130261124 | THERAPEUTIC METHODS AND AGENTS FOR TREATING MYOTONIC DYSTROPHY - The invention provides compounds, compositions and methods for treating myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit replication of the nucleic acids. | 10-03-2013 |
20130261010 | OPTICAL ANALYTE DETECTION SYSTEMS WITH MAGNETIC ENHANCEMENT AND METHODS OF USE - Various embodiments are drawn to systems and methods for detecting an analyte of interest in a solution that also contains a plurality of magnetic particles. The system may include a first magnet configured to generate a first magnetic field that forces the magnetic particles in the solution toward an optical sensor with a capture probe. A detector may be included to detect a change in an optical property of the optical sensor, the change in the optical property resulting from the binding of at least the analyte, a magnetic particle, and the capture probe at the optical sensor. | 10-03-2013 |
20130254945 | SOYBEAN APHID RESISTANCE GENE RAG2 - Provided herein are isolated nucleic acid molecules representing a genetically defined region of the genome of the aphid resistant soybean plant ( | 09-26-2013 |
20130252236 | TUMOR STEM CELLS - Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population. Another aspect provides methods of screening for anti-tumor stem cell teherapeutic compounds by providing high nitric oxide (HNO) tumor cells, exposing the HNO cells to at least one compound, assessing one or more indicators of HNO cell health and determining toxicity of the compound to HNO tumor cells. | 09-26-2013 |
20130236923 | Characteristic Parameters of Cells and Tissue from Quantitative Phase Imaging - Methods mapping a characteristic parameter of a specimen, such as a scattering mean free path and a scattering anisotropy factor, based on a quantitative phase shift measurement. The methods have steps of using spatial light interference microscopy (SLIM) to determine a quantitative phase shift as a function of position in a sample, and applying a generalized scatter-phase transformation to derive at least one of a scattering mean free path (MFP), a scattering anisotropy factor, and a thickness-independent parameter as a function of position in the sample. In some cases, the sample may be a slice of tissue or a cell. | 09-12-2013 |
20130236490 | Multivalent Vaccine for Filariasis - The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are protein-based, DNA-based, or a combination thereof. | 09-12-2013 |
20130225815 | Fluoroalkylation Methods And Reagents - A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1. | 08-29-2013 |
20130225531 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER'S DISEASE AND DEMENTIAS OF VASCULAR ORIGIN - A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans. | 08-29-2013 |
20130225434 | COMPOSITIONS COMPRISING ENGINEERED PHOSPHOTHREONINE AFFINITY REAGENTS, METHODS OF MAKING, AND METHODS OF USE - This invention relates to the use of protein scaffolds for producing affinity reagents that are polypeptides that specifically bind to phosphopeptides. | 08-29-2013 |
20130220443 | APPARATUS AND METHOD FOR FLOW CONTROL - A system that incorporates teachings of the present disclosure may include, for example, an apparatus including at least one first plate having at least one first opening and at least one second plate having at least one second opening. The apparatus can include a connector for coupling the at least one first plate and the at least one second plate, where the at least one first and second openings are offset to form a non-linear flow path for restricting flow of a fluid through the at least one first and second plates. Additional embodiments are disclosed. | 08-29-2013 |
20130217070 | PRODUCTION OF XYLITOL FROM A MIXTURE OF HEMICELLULOSIC SUGARS - Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct co-product of a biorefinery or ethanol facility, or as a stand-alone product produced from an agricultural or forestry biomass feedstock including using, e.g. ethanol waste streams. | 08-22-2013 |
20130210731 | COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS - The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development. | 08-15-2013 |
20130210723 | Use of the Insulin-Like-Growth Factor 1 Splice Variant MGF for the Prevention of Myocardial Damage - The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium. | 08-15-2013 |
20130209435 | METHODS FOR PREDICTING RISK OF STROKE - The invention provides methods of determining risk for stroke in a patient, as well as methods of determining a subject's need for anti-coagulation therapy. In exemplary embodiments, the method comprises measuring a level of derivatives of reactive oxygen metabolites (DROMs) in a biological sample obtained from the subject, wherein an increased level of DROMs, relative to a control level, is indicative of the subject's need for anticoagulation therapy. Further provided are methods of decreasing risk of stroke in a subject, methods of determining the efficacy of a therapeutic agent, methods of monitoring a subject's risk of stroke, and kits. | 08-15-2013 |
20130198912 | DNA SEQUENCE THAT CONFERS APHID RESISTANCE IN SOYBEAN - Provided herein are isolated nucleic acid molecules representing a genetically defined region of the genome of the aphid resistant soybean plant ( | 08-01-2013 |
20130196933 | Methods and Compositions Inhibiting Tumor Cell Proliferation - The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. | 08-01-2013 |
20130192468 | GAS PURIFICATION SYSTEM FOR LIQUEFACTION OF DILUTE GAS COMPONENTS - The invention provides gas purification systems for the recovery and liquefaction of low boiling point organic and inorganic gases, such as methane, propane, CO | 08-01-2013 |
20130190613 | Real-Time Biomechanical Dosimetry using Optical Coherence Elastography - Methods for quantifying, adjusting or terminating a dose of a therapeutic intervention applied to tissue of a patient. A therapeutic intervention of a specified intensity is applied to a region of interest of the tissue. The tissue is mechanically excited, typically concurrently with the therapeutic intervention, and the region of interest is scanned optically or ultrasonically at the same time. An interference signal is acquired by coherently detecting post-interaction illumination arising in the region of interest by interfering the post-interaction illumination with a reference beam derived from the identical source as that of the scanning. A phase and/or amplitude of response of the tissue relative to the mechanical excitation based on the interference signal. A spatially resolved measure of a property of the region of interest is derived based on the phase of response, allowing for adjustment or termination of the therapeutic intervention. | 07-25-2013 |
20130189784 | ANTI-HEPARAN SULFATE PEPTIDES THAT BLOCK HERPES SIMPLEX VIRUS INFECTION IN VIVO - Provided are anti-heparan sulfate peptides and methods that employ those peptides for the prevention or treatment of viral infections, including herpesviral infections such as α-herpesviral, β-herpesviral, and γ-herpesviral infections, which are exemplified by HSV-1. CMV, and HHV-8 viral infections, respectively. Peptides may comprise at least 10 amino acids of the amino acid sequences X | 07-25-2013 |
20130189690 | SCN5A Splice Variants for Use in Methods Relating to Sudden Cardiac Death and Need for Implanted Cardiac Defibrillators - Provided herein are methods of determining a subject's need for an implanted cardiac defibrillator, methods of determining a subject's risk for sudden cardiac death (SCD), arrhythmias, or heart failure, methods of determining a subject's need for an anti-arrhythmic agent, e.g., a sodium channel blocker, and methods of reducing risk of SCD in a subject. In exemplary embodiments, each of the methods comprise the step of determining a ratio, R | 07-25-2013 |
20130184313 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF - The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand. | 07-18-2013 |
20130174729 | INDIRECT REAL-TIME MONITORING AND CONTROL OF ELECTRICAL RESISTIVELY HEATED ADSORBENT SYSTEM - A method for indirectly monitoring and controlling an electrically resistive adsorption system. Adsorption of a predetermined adsorbate is conducted while indirectly monitoring electrical resistance of a unified adsorbent element. Breakthrough is predicted based upon the indirectly monitored electrical resistance and a previously measured mass loading relationship between the resistance of the unified adsorbent element and the loading of the unified resistance element with the predetermined adsorbate. Adsorption, regeneration and cooling cycles are controlled by a controller without any direct measurement of temperature or resistance of the element and characterizations of mass loading and temperature. Systems of the invention can have no sensors that contact the element, are in an adsorption vessel, and/or are downstream adsorption vessel. | 07-11-2013 |
20130172265 | Methods and Compositions for Inhibiting Tumor Cell Proliferation - The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. | 07-04-2013 |
20130171484 | Materials and Methods for Autonomous Battery Shutdown - An autonomous battery shutdown system includes a battery including an anode and a cathode, and an electrolyte composition between the anode and the cathode. The electrolyte composition includes an ionically conductive liquid containing lithium ions, and temperature-sensitive particles including a polymer having a melting temperature between 60° C. and 120° C. When the temperature of the battery exceeds 120° C., the temperature-sensitive particles form an ion barrier that traverses the battery. The resulting shutdown battery may have a specific charge capacity that is more than 98% lower than the specific charge capacity of the original battery. | 07-04-2013 |
20130169969 | Spatial Light Interference Tomography - Methods and a computer readable medium for deriving a quantitative phase contrast tomographic image of a specimen. The specimen is illuminated and a focus of the illuminating light is scanned to a plurality of depths within the specimen. Light transmitted through the specimen is spatially Fourier transformed at each of the plurality of depths to form a spatially transformed image, and at least one of the phase and amplitude of a plurality of spatial frequency components of the spatially transformed image is spatially modulated. An intensity image of the specimen plane as modulated with respect to spatial frequency components is detected and deconvolved at a plurality of spatially modulated instances to obtain a three-dimensional phase representation of the specimen at each of the plurality of distances relative to a fiducial plane. | 07-04-2013 |
20130169960 | Surface Enhanced Raman Spectroscopy on Optical Resonator (e.g., Photonic Crystal) Surfaces - Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces. | 07-04-2013 |
20130166766 | Streaming Service for Correlated Multi-Streaming - Multiple input devices at a source location capture data to be streamed to one or more destination locations. The captured data is provided to a streaming interface of a streaming service that encapsulates the captured data in streaming packets. The streaming interface provides the streaming packets to a streaming gateway of the streaming service that processes the streaming packets and transmits the streaming packets to a streaming gateway at the destination location. The streaming gateways manage the correlated streaming of the multiple data streams. Various processing of the data streams can be performed by the streaming gateways, including various user-defined and system-defined processing. | 06-27-2013 |
20130166218 | Methods And Systems For Sequence Alignment Computation - A system utilizes a Single Instruction Multiple Data (SIMD) processor to efficiently determine, in parallel, the optimal global alignment for multiple input sequence pairs. The system may partition a score matrix generated for the input sequence pair into multiple sectors. While determining the cell content for each of the cells in the score matrix, the system may selectively retain computed cell contents for upper and left boundary cells of the partitioned sectors. During a traceback process, the system may retrieve the retained boundary cells for a current sector and recompute the cell contents for the current sector. Then, the system may determine the traceback path for the current sector. The system may continue to process sectors one at a time until the traceback path for the score matrix, and accordingly the optimal global alignment for the input sequence pair, is determined. | 06-27-2013 |
20130158436 | DEVICE AND METHOD FOR MEASURING PRESSURE EXERTED ON A SURFACE - Provided are methods and devices for measuring pressure exerted against a surface. In an aspect, the surface corresponds to the urethra and the device measures the pressure exerted against the urethra. Methods include treatment of a patient suffering urinary stress incontinence. A pressure sensor system is used to determine, pre-surgically, the minimum pressure required to alleviate incontinence. During surgery, the pressure sensor system is employed to ensure the surgical intervention provides a corresponding minimum pressure that was clinically identified. In this manner, the surgical intervention is precisely monitored and measured to insure the appropriate pressure is exerted on the urethra to alleviate stress incontinence, thereby improving surgical outcome and decreasing post-operative complications. | 06-20-2013 |
20130158396 | MULTI-ANGULATED CATHETER - The present invention is directed to a multi-angulated catheter and methods of using the multi-angulated catheter. The multi-angulated catheter is so dimensioned as to facilitate accessing the left ventricle from an arm of a patient. The multi-angulated catheter generally includes in order: (a) a coiled end; (b) a first straight portion having a first straight portion length; (c) a first shaft including a distal end connected to the first straight portion and a proximal end opposite the distal end, the first shaft and the first straight portion defining a first obtuse angle, the first shaft having a first shaft length; and (d) a second shaft connected to the first shaft on said proximal end. The catheter is flexible so as to afford being straightened when it is advanced over a guide wire. The catheter resiliently returns to a multi-angulated position after the guide wire is withdrawn. | 06-20-2013 |
20130155058 | FOUR-DIMENSIONAL AUGMENTED REALITY MODELS FOR INTERACTIVE VISUALIZATION AND AUTOMATED CONSTRUCTION PROGRESS MONITORING - A method for monitoring construction progress may include storing in memory multiple unordered images obtained from photographs taken at a site; melding the multiple images to reconstruct a dense three-dimensional (3D) as-built point cloud model including merged pixels from the multiple images in 3D space of the site; rectifying and transforming the 3D as-built model to a site coordinate system existing within a 3D as-planned building information model (“as-planned model”); and overlaying the 3D as-built model with the 3D as-planned model for joint visualization thereof to display progress towards completion of a structure shown in the 3D as-planned model. The processor may further link a project schedule to the 3D as-planned model to generate a 4D chronological as-planned model that, when visualized with the 3D as-built point cloud, provides clash detection and schedule quality control during construction. | 06-20-2013 |
20130150649 | SENSITIZATION OF TUMOR CELLS TO RADIATION THERAPY THROUGH ADMINISTRATION OF ENDOTHELIN AGONISTS - Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ET | 06-13-2013 |
20130147798 | INSERTING OBJECTS INTO CONTENT - An image into which one or more objects are to be inserted is obtained. Based on the image, both a 3-dimensional (3D) representation and a light model of the scene in the image are generated. One or more objects are added to the 3D representation of the scene. The 3D representation of the scene is rendered, based on the light model, to generate a modified image that is the obtained image modified to include the one or more objects. | 06-13-2013 |
20130142784 | METHOD OF TREATING TUMOR RESISTANT TO HERCEPTIN OR PACLITAXEL USING FOXM1 INHIBITORS AND DETECTING SAME - The invention provides methods of treating cancer, especially breast cancer, and in particular HER2/ErbB2 positive breast cancer using a FoxM1 inhibitor in conjunction with trastuzumab and/or paclitaxel. Pharmaceutical compositions comprising a FoxM1 inhibitor in the presence of trastuzumab and/or paclitaxel are also provided. The invention further provides methods of identifying and treating trastuzumab resistant and/or paclitaxel resistant cancer. Also provided are methods of promoting breast tumor cell differentiation. | 06-06-2013 |
20130136722 | Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts - This invention provides methods and compositions of hematopoietic progenitor cells and hematopoietic stem cells, particularly methods for expanding populations of these cells types from biological sources. | 05-30-2013 |
20130132454 | Feedback-Based Particle Filtering - Methods for estimating a conditional probability distribution for signal states of a non-linear random dynamic process. The filter is based on multiple particles, each defined by a state space model similar to the dynamic process. Each particle is updated on the basis of a control input derived by proportional gain feedback on an innovation process. The innovation process is the difference between an increment in an observed quantity measured by one or more sensors and an average of a function of the particles. The particle filter of the invention may also be applied to filtering problems with data association uncertainty where multiple measurements are obtained, of which at most one originates from a specified target. | 05-23-2013 |
20130130734 | HIGH SENSITIVITY ENVIRONMENTAL SENSOR BOARD AND METHODS FOR STRUCTURAL HEALTH MONITORING - A smart sensor circuit board comprises an interface to a wireless smart sensor board platform, a multi-axis accelerometer having a sensitivity that can measure ambient structural vibrations resulting from non-catastrophic routine environmental factors, an analog to digital converter (ADC) for converting signals from the multi-axis accelerometer having a plurality of individual channels including oversampling, filtering, and decimation, and each channel being individually programmable for gain, anti-aliasing, cut-off frequency, sampling, and frequency providing data to the interface, and a low noise and high sensitivity amplifier having the plurality of individual channels to receive signals from the multi-axis accelerometer. | 05-23-2013 |
20130121918 | Nano-Hybrid Delivery System for Sequential Utilization of Passive and Active Targeting - The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto. | 05-16-2013 |
20130111425 | POWER BALANCED PIPELINES | 05-02-2013 |
20130110931 | Scalable Peer To Peer Streaming For Real-Time Data | 05-02-2013 |
20130102046 | XYLOSE-FERMENTING MICROORGANISM - The present disclosure provides compositions and methods related to the fermentation of xylose. Host cells having recombinant polynucleotides encoding one or more of aldose reductases, xylitol dehydrogenases, and xylulokinase are provided herein. Host cells having reduced expression of PHO13 are also provided herein. Also provided herein are uses of host cells provided herein, and methods relating to the use of xylose-containing materials. | 04-25-2013 |
20130101552 | METHODS AND COMPOSITIONS FOR CONTRIBUTING TO THE TREATMENT OF CANCERS - Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ET | 04-25-2013 |
20130095039 | NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES - Embodiments of a method to use nucleic acid oligomer sequences for modulating the shape of nanoparticles are disclosed, as well as nanoparticles and methods of using the nanoparticles. Systematic variations of the nucleic acid sequences offer mechanistic insights into the morphology control. A plurality of nucleic acid oligomers is adsorbed onto a metal nanoseed to provide an oligomer-functionalized nanoparticle. Additional metal is deposited onto the oligomer-functionalized nanoparticle to produce a shaped nanoparticle having a morphology based at least in part on the nanoseed morphology and the oligomer's sequence composition. Embodiments of methods for using the shaped nanoparticles also are disclosed. | 04-18-2013 |
20130094532 | Opto-Electronic Oscillator And Method - An opto-electronic oscillator circuit, including: an opto-electronic circuit loop including an optical modulator that receives a first electrical signal and produces an optical output signal coupled with an optical resonator, a photodetector circuit optically coupled with the optical resonator, and a phase shifter coupled with the photodetector circuit for producing a phase shifted output signal that is fed back as the first electrical signal; an optical loop comprising the optical coupling of the optical resonator with the photodetector; and an electrical feedback circuit loop for coupling the first electrical signal with the photodetector circuit. | 04-18-2013 |
20130093352 | Opto-Electronic Devices And Methods - A method for amplifying an input optical signal includes the following steps: providing a light-emitting transistor device having a base region between collector and emitter regions; applying electrical signals with respect to the base, collector, and emitter regions to produce light emission from the base region of the light-emitting transistor device; and applying the input optical signal to the base region of the light-emitting transistor device to produce an amplified optical output from the base region. | 04-18-2013 |
20130091578 | SYSTEM AND A METHOD FOR AUTOMATICALLY DETECTING SECURITY VULNERABILITIES IN CLIENT-SERVER APPLICATIONS - A method for automatically detecting security vulnerabilities in a client-server application where a client is connected to a server. The method is implemented by a computer having a processor and a software program stored on a non-transitory computer readable medium. The method includes automatically extracting, with the software program at the client, a description of one or more validation checks on inputs performed by the client. The method also includes analyzing the server, with the software program by using the one or more validation checks on inputs performed by the client, to determine whether the server is not performing validation checks that the server must be performing. The method further includes determining that security vulnerabilities in the client-server application exist when the server is not performing validation checks that the server must be performing. A method further proposes preventing parameter tampering attacks on a running client-server application by enforcing the one or more validation checks on inputs performed by the client on each input that is submitted to the server. | 04-11-2013 |
20130084247 | COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS - The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer. | 04-04-2013 |
20130080079 | SELF-CALIBRATING MASS FLOW SENSOR SYSTEM - Method and system for calibrating a mass flow sensor. The mass flow sensor includes an impact sensor that receives an impact force due to collisions with a plurality of solid particles to generate an output signal. A model relates a mass flow input to the output signal. At least one measurable parameter is varied over a plurality of samples by varying a physical component of the mass flow sensor, and a generated output signal is received. The model can be calibrated based on the received output signal for each of the plurality of samples. A mass-flow input can also be estimated while simultaneously updating the model. | 03-28-2013 |
20130079417 | Highly Selective 5-HT(2C) Receptor Agonists That Show Anti-Psychotic Effects with Antagonist Activity at the 5-HT(2B) Receptor - Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders. | 03-28-2013 |
20130079309 | Method Of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists - The invention provides methods for treating or reducing the risk of developing acute lung injury manifested by increased vascular permeability. Also provided are pharmaceutical compositions comprising an FTY720 analog or derivative and/or SEW 2871 for use in the disclosed methods. The invention also provides methods for treating or reducing the risk of developing acute lung injury resulting from dysregulation of ceramide/sphingolipid pathway, more specifically, acute lung injury resulting from radiation. | 03-28-2013 |
20130078275 | NOVEL SYSTEMS, VECTORS, AND METHODS FOR DELIVERY OF BIOMOLECULES TO EUKARYOTIC CELLS - Embodiments described herein provide novel bacterial-based methods, systems, and delivery vehicles capable of delivering DNA, RNA, proteins, and other cargo into targeted mammalian cells, both in vitro and in vivo, with high efficiency. Delivery vehicles may be used to deliver molecules such as prophylactic or therapeutic proteins, DNA, shRNA, DNA vaccines, mucosal vaccines, modified viruses or viral components, and other bioactive molecules. Potential applications include gene therapy, wound healing therapies, cancer therapy, immune modulation, and research applications for which delivery of DNA, RNA, proteins, or other cargo into mammalian cells and tissues is required. | 03-28-2013 |
20130072596 | Thermally Robust Capsule System, And Composites Including The Capsules - A method of making capsules includes forming a mixture including a core liquid, a polyurethane precursor system, a first component of a two-component poly(urea-formaldehyde) precursor system, and a solvent. The method further includes emulsifying the mixture, adding a second component of the two-component poly(urea-formaldehyde) precursor system to the emulsified mixture, and maintaining the emulsified mixture at a temperature and for a time sufficient to form a plurality of capsules that encapsulate at least a portion of the core liquid. The capsules made by the method may include a polymerizer in the capsules, where the capsules have an inner capsule wall including a polyurethane, and an outer capsule wall including a poly(urea-formaldehyde). The capsules may include in the solid polymer matrix of a composite material. | 03-21-2013 |
20130072433 | INHIBITORS OF BETA INTEGRIN-G PROTEIN ALPHA SUBUNIT BINDING INTERACTIONS - Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation. | 03-21-2013 |
20130071297 | ARRAYS OF METAL AND METAL OXIDE MICROPLASMA DEVICES WITH DEFECT FREE OXIDE - A microplasma device includes a microcavity or microchannel defined at least partially within a thick metal oxide layer consisting essentially of defect free oxide. Electrodes are arranged with respect to the microcavity or microchannel to stimulate plasma generation in said microcavity or microchannel. At least one of the electrodes is encapsulated within the thick metal oxide layer. A method of fabricating a microcavity or microchannel plasma device includes anodizing a flat or gently curved or gently sloped metal substrate to form a thick layer of metal oxide consisting essentially of nanopores that are perpendicular to the surface of the metal substrate. Material removal is conducted to remove metal oxide material to form a microcavity or microchannel in the thick layer of metal oxide. | 03-21-2013 |
20130065042 | Micro-Vascular Materials And Composites For Forming The Materials - A microvascular system includes a solid polymeric matrix and a woven structure in the matrix. The woven structure includes a plurality of fibers, and a plurality of microfluidic channels, where at least a portion of the microfluidic channels are interconnected. The microvascular system may be made by forming a composite that includes a solid polymeric matrix and a plurality of sacrificial fibers in the matrix, heating the composite to a temperature of from 100 to 250° C., maintaining the composite at a temperature of from 100 to 250° C. for a time sufficient to form degradants from the sacrificial fibers, and removing the degradants from the composite. The sacrificial fibers may include a polymeric fiber matrix including a poly(hydroxyalkanoate) and a metal selected from the group consisting of an alkali earth metal and a transition metal, in the fiber matrix, where the concentration of the metal in the fiber matrix is at least 0.1 wt %. | 03-14-2013 |
20130049240 | ENCAPSULATED MATERIALS AND METHODS FOR ENCAPSULATING MATERIALS - A system that incorporates teachings of the present disclosure may include, for example, a method for applying a force to at least one of an inner stream, an outer stream or both of a combined stream to produce a plurality of capsules, receiving image data, processing the image data, detecting undesirable capsules from the processed image data, applying a bias charge only to the detected undesirable capsules, and segregating the biased undesirable capsules from the unbiased desirable capsules. Additional embodiments are disclosed. | 02-28-2013 |
20130040886 | Peptides and Methods for Inhibiting G alpha Protein Signaling - The present invention comprises peptide compositions and methods for specifically inhibiting signaling through Gα subunits. | 02-14-2013 |
20130017175 | ACTIVATED MESENCHYMAL STEM CELLS FOR WOUND HEALING AND IMPAIRED TISSUE REGENERATION - Inflammatory cytokines e.g. IFN-γ, serve as initiating stimuli for mesenchymal stem cell (MSC) immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation of MSC, may also provide such a response. Activated MSC's promote tissue regeneration in conditions such as aging, where regeneration is impaired. Wound healing in aged mammals was enhanced by restoring tensile strength to the levels of younger mammals. Activated MSCs were useful in treating wounds in diabetic primates. | 01-17-2013 |
20130011338 | CUPREDOXIN DERIVED TRANSPORT AGENTS AND METHODS OF USE THEREOF - The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer. | 01-10-2013 |
20130004431 | TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from | 01-03-2013 |
20120321785 | Methods of Making Spatially Aligned Nanotubes and Nanotube Arrays - The present invention provides arrays of longitudinally aligned carbon nanotubes having specified positions, nanotube densities and orientations, and corresponding methods of making nanotube arrays using guided growth and guided deposition methods. Also provided are electronic devices and device arrays comprising one or more arrays of longitudinally aligned carbon nanotubes including multilayer nanotube array structures and devices. | 12-20-2012 |
20120315621 | PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF A BROAD RANGE OF ANALYTES - A methodology for developing highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and a PGM. Also provided are sensors, which can include a solid support having attached thereto a recognition molecule that permits detection of a target agent, as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are provided. | 12-13-2012 |
20120308611 | FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 12-06-2012 |
20120302509 | COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS - The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from | 11-29-2012 |
20120300293 | Simple Ultra-Stable Stage with Built-in Fiduciary Markers for Fluorescence Nanoscopy - An improved microscope stage mount with built-in fiduciary markers is used for fluorescence microscopy, and comprises: (a) an optically-transparent glass plate adapted for specimen mounting and microscope viewing and comprising a specimen mounting area; and (b) a defined and ordered, two-dimensional microscopic array of fiduciary markers, wherein the markers are polymeric pillars affixed to the plate about the specimen mounting area, wherein the markers provide a three-dimensional spatial reference for the specimen. | 11-29-2012 |
20120290088 | System and Method for Prosthetic Fitting and Balancing in Joints - A device for intraoperative use in balancing joint forces and verifying the placement of the tibial component in total knee arthroplasty includes a spacer defining an enclosure; the spacer is sized to engage a top portion of the tibial component. A sensor array is embedded in the spacer, the sensor array measures forces on the spacer. A wireless transceiver is embedded in the spacer and forwards the output to a processor. The processor is analyzes the output and creates a pressure distribution graph indicative of the forces on the spacer, thereby assisting a surgeon in performing selective soft tissue release or component positioning in connection with surgical implantation of an orthopedic knee prosthesis. | 11-15-2012 |
20120289870 | PORTABLE ACTIVE PNEUMATICALLY POWERED ANKLE-FOOT ORTHOSIS - A portable active fluid-powered ankle foot orthosis. A lower leg mount and a foot bed are pivotally coupled at or proximate to an ankle position. A fluid powered rotary actuator is configured to receive power from a wearable fluid power source and provide controlled force and resistance to aid or inhibit relative rotation of the foot bed and the lower leg mount. An integral controller is provided for receiving data from sensors and controlling the fluid powered rotary actuator to actively assist gait of a user. | 11-15-2012 |
20120289482 | Method for modulating or controlling connexin 43(Cx43) level of a cell and reducing arrhythmic risk - A method of modulating or controlling connexin 43 (Cx43) level of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell. | 11-15-2012 |
20120288486 | Method for Ameliorating or Preventing Arrhythmic Risk Associated with Cardiomyopathy - A method for reducing arrhythmic risk associated with cardiomyopathy includes administering a composition containing NAD | 11-15-2012 |
20120279306 | Mechanical Nanoresonator for Extremely Broadband Resonance - In an embodiment, provided are nanoresonators, nanoresonator components and related methods using the nanoresonators to measure parameters of interest. In an aspect, provided is a nanoresonator component comprising an elongated nanostructure having a central portion, a first end, and a second end and an electrode having a protrusion ending in a tip that is positioned adjacent to the elongated nanostructure. The electrode is used to impart a highly-localized driving force in a perpendicular direction to the nanostructure to induce geometric non-linear deformation, thereby generating non-linear resonance having a broadband resonance range that spans a frequency range of at least one times the elongated nanostructure natural resonance frequency. | 11-08-2012 |
20120261182 | LIQUID-REPELLENT, LARGE-AREA, ELECTRICALLY-CONDUCTING POLYMER COMPOSITE COATINGS - A polymeric composition including a blend of poly(vinylidine fluoride) (PVDF), poly(methyl methacrylate) (PMMA), carbon nanofibers, and poly(tetrafluoroethylene) (PTFE) particles is described and claimed. The polymeric composition may be coated onto a substrate and dried to form a film adhered to the substrate. The film optionally exhibits an electrical conductivity of about 10 Siemens per meter (S/m) to about 310 S/m and an electromagnetic interference shielding of about 32 decibels. Further, a coated substrate is provided including a substrate and a film adhered to the substrate, where the film includes a polymeric composition comprising a blend of PVDF, PMMA, carbon nanofibers, and PTFE particles. | 10-18-2012 |
20120258549 | External cavity laser biosensor arrangements - A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter. | 10-11-2012 |
20120256102 | Dye-conjugated dendrimers - The invention provides dendrimers, conjugates thereof, and methods of using dendrimer conjugates. In one embodiment, the invention provides novel polymeric dendrimers as a new class of fluorescent labels. The labels can include multiple fluorescent dye molecules conjugated to a single polymeric backbone or core, such as a dendrimer. The dendrimers can have regular or irregular branched polymeric network structures that allow for the chemical attachment of multiple dye molecules, multiple color dyes, and/or multiple functional groups, in a combinatorial fashion. The fluorescent dendritic nanoprobes (FDNs) thus provide a new class of fluorescent reporters for fluorescence microscopy and imaging. | 10-11-2012 |
20120248020 | CHROMATOGRAPHY DEVICES AND METHODS - Provided are chromatography devices having a stationary phase that includes patchy particles having at least two different surface chemistries, such as Janus particles. Also provided are methods of separating at least one analyte out of a sample, where the method includes adding a sample having at least one analyte to a chromatography device that includes a stationary phase that includes a plurality of patchy particles. Further provided are methods that include packing a chromatography column with a plurality patchy particles having at least two different surface chemistries. Additional embodiments are disclosed. | 10-04-2012 |
20120231540 | Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus - Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies. | 09-13-2012 |
20120231083 | SUSTAINED RELEASE CANNABINOID MEDICAMENTS - The present invention provides a medicament which results in delivery of a therapeutic level of one or more cannabinoids during a clinically relevant therapeutic window. The therapeutic window is a longer window than provided by an immediate release medicament such as Marinol containing an equivalent amount of the cannabinoid. Oral administration of the present compositions provides therapeutic dosing while maintaining safe, side effect sparing, levels of a cannabinoid. The present invention also provides methods of treating cannabinoid-sensitive disorders. | 09-13-2012 |