The Board of Trustees of the University of Arkansas Patent applications |
Patent application number | Title | Published |
20160114025 | COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES - Provided herein are | 04-28-2016 |
20160075689 | POLYMERASE, ENDONUCLEASE, AND HELICASE INHIBITORS AND METHODS OF USING THEREOF - Inhibitors of DNA damage polymerases, endonucleases, and helicases are provided. In particular, compounds comprising Formula (I) are described. | 03-17-2016 |
20160039873 | PEPTIDES WITH ANTIFUNGAL ACTIVITY AND METHODS OF USING THE PEPTIDES - Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1 and variations thereof. The peptides may contain L or D amino acids and may be circularized, dimerized or otherwise modified to make the compositions resistant to proteolysis. The compositions may be used to inhibit microbial growth and in particular fungal growth. | 02-11-2016 |
20160032313 | METHODS OF INCREASING RESISTANCE OF CROP PLANTS TO HEAT STRESS AND SELECTING CROP PLANTS WITH INCREASED RESISTANCE TO HEAT STRESS - Methods of increasing the resistance of a crop plant to heat stress and in particular methods of improving the grain yield and quality of crop plants grown under heat stress in the form of increased minimal temperatures are provided. The methods include selecting plants with increased expression of HYR and growing these plants in regions expected to experience minimal temperatures above 25° C. during the growing season. Methods of screening plants for increased resistance to heat stress and methods of producing grain in regions having minimal temperatures of 25° C. or more are also provided. | 02-04-2016 |
20160000895 | COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION - Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or morality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector. | 01-07-2016 |
20150374394 | SONOLYSIS WITH BIODEGRADABLE NANOPARTICLES - The present invention provides methods for lysing a thrombus or ablating a mass in a subject by administering a plurality of biodegradable nanoparticles and delivering ultrasound to the subject. Also provided is a method for delivering a therapeutic agent to a tumor in a subject by administering a plurality of biodegradable nanoparticles comprising the therapeutic agent and delivering ultrasound to the subject. | 12-31-2015 |
20150351297 | Blackberry plant named 'APF-153T' - Description and specifications of a new and distinct blackberry cultivar named ‘APF-153T’ which originated from seed produced by a hand-pollinated cross of Ark. Selection A-2301T (non-patented, unreleased genotype)×APF-49T (non-patented, unreleased genotype) is provided. This new blackberry cultivar can be distinguished by its very large attractive fruit, very good flavor, excellent plant health, very early ripening, thornless, erect canes and primocane fruiting habit. | 12-03-2015 |
20150315654 | Chondroitin Sulfate Sulfotransferases and Proteoglycans as Cancer Biomarkers: Use of Expression and Methalytion Status - A method of determining a prognosis of a cancer in a human comprising: determining expression level of CHST11 in a cancer tissue sample or determining methylation status of CHST11 gene in a cancer tissue sample. CHST11 is Carbohydrate (Chondroitin 4) Sulfotransferase 11. | 11-05-2015 |
20150297714 | NOVEL MUCOSAL ADJUVANTS AND DELIVERY SYSTEMS - Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject. | 10-22-2015 |
20150216954 | COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA - Vaccines comprising TRAP polypeptides and | 08-06-2015 |
20150190500 | VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES - Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject. | 07-09-2015 |
20150190496 | VACCINE AND METHODS TO REDUCE CAMPYLOBACTER INFECTION - Vaccine vectors and methods for enhancing resistance to | 07-09-2015 |
20150183772 | ALKYLATION OF AZOLES - In one aspect, methods for the alkylation of azoles are described herein. In some embodiments, a method for the C2 alkylation of an azole compound comprises providing an azolium salt comprising an N-allyl substituent, reacting the N-allyl azolium salt with an aldehyde to provide a reaction product mixture comprising a ketone and N-allyl-N,X-ketene acetal, and providing the C2-alkylated azole compound by Claisen rearrangement of the N-allyl-N,X-ketene acetal, wherein X is selected from the group consisting of S, N and O. | 07-02-2015 |
20150150169 | Blackberry plant named 'A-1960' - Description and specifications of a new and distinct blackberry cultivar named ‘A-1960’ which originated from seed produced by a hand pollinated cross of Ark. Selection Ark.-1583 (non-patented, unreleased genotype; female)×Ark.-1482 (non-patented, unreleased genotype; male) is provided. This new blackberry cultivar can be distinguished by its very firm fruit with long shape, medium-large size, attractive fruit appearance, very good flavor, excellent plant health, and cane erectness. | 05-28-2015 |
20150106983 | Peach tree named 'Souvenirs' - Description and specification of a new and distinct peach tree cultivar named ‘Souvenirs’ which originated from a hand-pollinated cross of Ark. 708 (non-patented)×Winblo (non-patented) made in 2001. This new peach cultivar can be distinguished by its very firm fruit with slow-melting yellow flesh, early-mid season ripening, medium size, attractive appearance, high red skin color, excellent fruit quality, good flavor, and resistance to bacterial spot disease. | 04-16-2015 |
20150106982 | Nectarine tree named 'Amoore Sweet' - Description and specification of a new and distinct nectarine tree cultivar named ‘Amoore Sweet’ which originated from a hand-pollinated cross of Ark. 699N×Ark. 663CN made in 2001. This new nectarine cultivar can be distinguished by its very firm, non-melting yellow flesh, early-mid season ripening, medium-sized fruits, excellent fruit quality with distinct low-acid nectarine flavor, and resistance to bacterial spot disease. | 04-16-2015 |
20150106981 | Nectarine tree named 'Bowden' - Description and specification of a new and distinct nectarine tree cultivar named ‘Bowden’ which originated from a hand-pollinated cross of Ark. 699N×Ark. 663CN made in 2001. This new nectarine cultivar can be distinguished by its very firm, non-melting white flesh, early-mid season ripening, medium-sized fruits, excellent fruit quality with distinct white nectarine flavor, and resistance to bacterial spot disease. | 04-16-2015 |
20150040279 | Grape plant named 'Faith' - Description and specifications of a new and distinct grapevine cultivar named ‘Faith’ which originated from a hand-pollinated cross of A-1962 (non-patented, non-released breeding genotype)×Jupiter (U.S. Plant Pat. No. 13,309) made in 1990. This new grapevine cultivar can be distinguished by its seedless, blue/black berries of with neutral and occasional slight fruity flavor, medium sized clusters, medium vigor, and healthy plant. | 02-05-2015 |
20150040278 | Grape plant named 'Joy' - Description and specifications of a new and distinct grapevine cultivar which originated from a hand-pollinated cross of A-1919 (non-patented, non-released breeding genotype)×A-1908 (non-patented, non-released breeding genotype). This new grapevine cultivar can be distinguished by its seedless, blue berries of exceptionally fruity flavor, medium sized clusters, moderate to high yield, medium vigor, and healthy plant. | 02-05-2015 |
20150040277 | Grape plant named 'Gratitude' - Description and specifications of a new and distinct grapevine cultivar named ‘Gratitude’ which originated from a hand-pollinated cross of A-1925 (non-patented, non-released breeding genotype; female)×A-1581 (non-patented, non-released breeding genotype; male). This new grapevine cultivar can be distinguished by its seedless, green, crisp berries with neutral flavor and resists cracking from rainfall at maturity. The fruit grows in large tight clusters, the vines have medium vigor, and the plants are healthy. | 02-05-2015 |
20150040276 | Grape plant named 'Hope' - Description and specifications of a new and distinct grapevine cultivar named ‘Hope’ which originated from a hand-pollinated cross of A-1562 (non-patented, non-released breeding genotype)×A-1704 (non-patented, non-released breeding genotype). This new grapevine cultivar can be distinguished by its very tight large clusters, fruity flavor, high yields, medium vigor, and healthy plant. | 02-05-2015 |
20140308511 | Multi-Layer Coating with Cubic Boron Nitride Particles - A physical configuration of multiple-layer coatings formed with at least one layer of coating containing cubic born nitride (cBN) particles with one or more layers in composite form containing cBN particles may have a thickness of each individual layer as thin as in the nanometer range, or as thick as in the range of a few microns and even up to tens of microns. The chemistry of the composite layer consists of any individual phase of (a) nitrides such as titanium nitride (TiN), titanium carbonitride (TiCN), and hafnium nitride (HfN); (b) carbides such as titanium carbide (TiC); and (c) oxides such as aluminum oxide (Al | 10-16-2014 |
20140248290 | INHIBITION OF CANCER METASTASIS - P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis. | 09-04-2014 |
20140231351 | MAGNETICALLY RESPONSIVE MEMBRANES - The invention provides permeable magnetically responsive filtration membranes that include a filtration membrane polymer base suitable for fluid filtration; hydrophilic polymers conjugated to the surface of the filtration membrane polymer; and magnetic nanoparticles affixed to the ends of a plurality of the hydrophilic polymers, wherein the hydrophilic polymers are movable with respect to the surface of the filtration membrane polymer surface in the presence of an oscillating magnetic field. | 08-21-2014 |
20140193426 | MARKERS FOR EARLY DIAGNOSIS OF OVARIAN CANCER, MONITORING DURING THERAPY, AND NEW THERAPY OPTIONS DURING AND AFTER CHEMOTHERAPY - The inventors have identified several proteases and a protease inhibitor that are overexpressed in ovarian cancer tumors. They have developed monoclonal antibodies against the proteins and shown that they can be detected in serum and the levels of the proteins in serum fluctuate during cancer treatment. They have shown that serum assays for the proteases and protease inhibitor can be used for early detection of ovarian cancer, and for monitoring cancer treatment. | 07-10-2014 |
20140154711 | DETECTION OF DEFENSINS TO DIAGNOSE CANCER - Non-invasive methods of detecting and providing an early diagnosis of cancer, in particular breast cancer are provided herein. The methods include obtaining a sample, suitably an ocular wash sample, from a subject and determining the level of α-Defensin 1, α-Defensin 2 and/or α-Defensin 3 in the sample. Increased levels of any of these proteins as compared to a negative control or non-cancerous subject are indicative of cancer in the subject from which the sample was obtained. Kits for performing the methods described herein are also provided. | 06-05-2014 |
20140093534 | COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES - Provided herein are | 04-03-2014 |
20140090122 | Blackberry plant named 'A-2312' - Description and specifications of a new and distinct blackberry cultivar named ‘A-2312’ which originated from seed produced by a hand pollinated cross of Ark. Selection APF-1 (non-patented, unreleased genotype)×A-2002 (non-patented, unreleased genotype) is provided. This new blackberry cultivar can be distinguished by its firm, large, sweet fruit with excellent postharvest handling potential, attractive fruit appearance, very good flavor, excellent plant health, potential reduced chilling requirement compared to other University of Arkansas's cultivars, and high yields. | 03-27-2014 |
20140037579 | Inhibition of Dendritic Cell-Driven Regulatory T Cell Activation and Potentiation of Tumor Antigen-Specific T Cell Responses by Interleukin-15 and MAP Kinase Inhibitor - The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided. | 02-06-2014 |
20130323218 | Methods of Selecting and Using Therapeutic and Prophylactic Probiotic Cultures to Reduce Bacterial Pathogen Loads - Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. or capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided. | 12-05-2013 |
20130281795 | WEARABLE REMOTE ELECTROPHYSIOLOGICAL MONITORING SYSTEM - A wearable remote electrophysiological monitoring system. The system includes a garment having at least one nanostructured, textile-integrated electrode attached thereto; a control module in electrical communication with the at least one nanostructured, textile-integrated sensor; and a remote computing system in communication with the control module. | 10-24-2013 |
20130183274 | MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS - Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same. | 07-18-2013 |
20130174305 | Blackberry plant named 'APF-77' - Description and specifications of a new and distinct blackberry cultivar named ‘APF-77’ which originated from seed produced by a hand pollinated cross of APF-12 (U.S. Plant Pat. No. 16,989)×Arapaho (U.S. Plant Pat. No. 8,510) is provided. This new blackberry cultivar can be distinguished by its primocane-fruiting trait with attractive, large fruit with excellent flavor, excellent plant health, and erect canes and enhanced performance for fruit set and development in high summer temperatures. | 07-04-2013 |
20130136695 | METHODS AND COMPOSITIONS INCLUDING SPORE-FORMING BACTERIA FOR INCREASING THE HEALTH OF ANIMALS - Methods, compositions and bacterial isolates for improving the gastrointestinal health of animals and in particular of poultry are provided herein. The methods include administering an endospore-forming bacteria to an animal. The bacteria are selected for the ability to reduce the growth and presence of bacterial pathogens, such as | 05-30-2013 |
20130116174 | COMPOSITIONS AND METHODS FOR INCREASING POULTRY HATCHABILITY AND EARLY PERFORMANCE - Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates. | 05-09-2013 |
20130102539 | PEPTOIDS AND METHODS FOR TREATING ALZHEIMER'S DISEASE - Provided herein are peptoids capable of inhibiting or reversing amyloid β (Aβ) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at least two monomers with a side-chain having an arylalkyl group having the same chirality positioned such that the side-chains are on the same side of the peptoid. Also provided are methods of using the peptoids to inhibit or reverse aggregation of Aβ and methods of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD. | 04-25-2013 |
20130095480 | Chondroitin Sulfate Sulfotransferases and Proteoglycans as Cancer Biomarkers: Use of Expression and Methalytion Status - A method of determining a prognosis of a cancer in a human comprising: determining expression level of CHST11 in a cancer tissue sample or determining methylation status of CHST11 gene in a cancer tissue sample. CHST11 is Carbohydrate (Chondroitin 4) Sulfotransferase 11. | 04-18-2013 |
20130084304 | VACCINE AND METHODS TO REDUCE CAMPYLOBACTER INFECTION - Vaccine vectors and methods for enhancing resistance to | 04-04-2013 |
20130017174 | COMPOSITIONS AND METHODS FOR INCREASING HEALTH AND REDUCING PATHOGENIC BACTERIA IN ANIMALS - Probiotic compositions comprising a bacterium that is capable of producing nitric oxide and a substrate of nitric oxide synthase are provided. Also provided are methods of improving the gastrointestinal health of a subject by orally administering a bacterium capable of producing nitric oxide and orally administering a substrate of nitric oxide synthase. Methods of reducing the inflammatory immune response after treatment with a probiotic and methods of reducing horizontal transmission of pathogenic bacteria within groups of animals are also provided. | 01-17-2013 |
20120297511 | Grape plant named 'A-1710' - Description and specifications of a new and distinct grapevine cultivar which originated from a hand-pollinated cross of Moored (non-patented)×NY | 11-22-2012 |
20120293198 | ULTRA-LOW POWER MULTI-THRESHOLD ASYNCHRONOUS CIRCUIT DESIGN - A multi-threshold null convention logic circuit. The circuit includes a first circuit, a first high-threshold transistor coupled to V | 11-22-2012 |
20120282291 | VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES - Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject. | 11-08-2012 |
20120244518 | ORGAN COLD STORAGE COMPOSITION AND METHODS OF USE - The present invention provides compositions and methods for decreasing oxidative damage to an organ during cold storage. | 09-27-2012 |
20120184536 | COMPOSITIONS COMPRISING SPECIFIC UGT INHIBITORS AND METHODS OF USE THEREOF - The present invention encompasses compositions comprising UGT inhibitors. Additionally, the invention encompasses methods of reducing the glucuronidation of a compound using a UGT inhibitor. | 07-19-2012 |
20120175567 | Colloidal Semiconductor Nanocrystals Having 1-Dimensional Quantum Confinement And Methods Of Making The Same - In some embodiments, a nanocrystal described herein comprises a semiconductor material MX, wherein M is a group II or a group III element and X is a group V or a group VI element to provide a II/VI compound or a III/V compound, the nanocrystal having lateral dimensions and a vertical dimension having the shortest axis, wherein surfaces of the nanocrystal normal or substantially normal to the axis of the vertical dimension comprise a layer of M ions passivated by a counter ion chemical species. | 07-12-2012 |
20120165280 | METHOD FOR IMPROVING BLOOD FLOW USING STILBENOID DERIVATIVES - The present invention generally provides methods for using stilbenoid derivatives to improve blood flow and microcirculation. | 06-28-2012 |
20120064046 | MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS - Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same. | 03-15-2012 |
20120041357 | METHOD OF CONTROLLED DRUG RELEASE FROM A LIPOSOME CARRIER - Disclosed are methods and compositions for the controlled release of a drug or agent from a liposome using light or radiation. Also disclosed are compositions comprising liposomes having a lipid layer, wherein the liposomes contain an agent, an enzyme capable of releasing the agent from the liposome, and an enzyme activator sequestered by a molecular cage. In another aspect, methods of delivering an agent to a target in a subject are disclosed. | 02-16-2012 |
20110307983 | Peach tree named 'White Diamond' - Description and specification of a new and distinct peach tree cultivar named ‘White Diamond’ which originated from a hand-pollinated cross of Ark. 392 (female, non-patented, unreleased genotype)בWhite River’ (male, U.S. Plant Pat. No. 15,159) is provided, This new peach tree cultivar can be distinguished by its late-season maturity, firm flesh, low-acid flavor, large freestone fruits and resistance to bacterial spot disease. | 12-15-2011 |
20110306048 | BOVINE POLYMORPHISMS AND METHODS OF PREDICTING BOVINE TRAITS - Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the subject. Also provided are kits for and methods of determining the nucleotide present in a bovine subject at a position in which a single nucleotide polymorphism is correlated with a trait. | 12-15-2011 |
20110302680 | Blackberry plant named APF-45 - Description and specifications of a new and distinct blackberry cultivar named ‘APF-45’ which originated from seed produced by a hand pollinated cross of Ark. Selection APF-1 (non-patented, unreleased genotype)×APF-12 (U.S. Plant Pat. No. 16,989) is provided. This new blackberry cultivar can be distinguished by its very firm fruit with excellent postharvest handling potential, medium-large size, attractive fruit appearance, very good flavor, excellent plant health, and cane erectness. | 12-08-2011 |
20110251469 | WIRELESS NANOTECHNOLOGY BASED SYSTEM FOR DIAGNOSIS OF NEUROLOGICAL AND PHYSIOLOGICAL DISORDERS - A wireless system for neurological and physiological monitoring of a patient. The system includes a patient monitoring unit having a headcap and a belt. The headcap includes a wireless communication module, an antenna, and an amplifier. The headcap further includes at least one of a biopotential electrode, a temperature sensor, a rotation sensor, an accelerometer, and an airflow sensor. The belt includes a respiration sensor comprising a carbon nanotube-based strain sensor. The system also includes a base receiver-server unit including a wireless receiving unit, a data storage unit, and a network communications unit. The system also includes a client monitoring unit which includes a processor, a network communications unit operably coupled to the processor, and a storage medium operably coupled to the processor, wherein the storage medium includes program instructions executable by the processor for receiving and processing data from the patient monitoring unit. | 10-13-2011 |
20110044903 | METHODS FOR PRODUCING MICROBUBBLES - The present invention provides methods for the preparation of gas-filled microbubbles, and methods of using for therapeutic and/or diagnostic applications. In particular, the methods of the invention allow for the preparation of gas-filled microbubbles having narrow size distributions and defined ultrasonic properties. | 02-24-2011 |
20100184160 | STAPHYLOCOCUS AUREUS STRAIN CYL1892 - This disclosure presents embodiments of novel strains of | 07-22-2010 |
20100143391 | HAPTEN COMPOUNDS AND COMPOSITIONS AND USES THEREOF - The invention generally relates to hapten compounds comprising either (+)methamphetamine or (+)amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+)methamphetamine, (+)amphetamine, or (+)MDMA. | 06-10-2010 |
20100028454 | Preparation method for biodegradable micro-particles containing drugs - The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer-drug-organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug-containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier. | 02-04-2010 |
20080221216 | Use of modafinil to treat spasticity - The invention provides a method of reducing spasticity in a mammal involving administering modafinil or related compounds. The spasticity can be secondary to multiple sclerosis, spinal cord injury, stroke, brain injury, and other causes. | 09-11-2008 |
20080199885 | Overexpression of mammaglobin B in ovarian and endometrial tumors - a new diagnostic and therapeutic marker - The invention involves the discovery that the mammaglobin B gene is the single most overexpressed gene in primary ovarian serous papillary cancer over normal ovarian epithelium among over 14,000 genes tested. It is expressed over 800-fold higher in primary ovarian tumors than normal ovarian epithelium. Mammaglobin B gene expression was detected in endometrioid, mucinous, undifferentiated, serous papillary, clear cell, and mixed histology ovarian tumors. The protein can be found in blood and ascites fluid, and a simple blood test for the presence of mammaglobin B protein can provide early detection of ovarian and other cancers. The invention provides a method of screening for cancer involving detecting mammaglobin B in a fluid sample. | 08-21-2008 |