Tel HaShomer Medical Research Infrastructure and Services Ltd. Patent applications |
Patent application number | Title | Published |
20160032393 | METHODS AND KITS FOR PREDICTING PROGNOSIS OF MULTIPLE SCLEROSIS - Provided are methods and kits for predicting the prognosis of a subject diagnosed with multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with multiple sclerosis and having good or poor clinical outcome. Also provided are methods and kits for selecting a treatment regimen of a subject diagnosed with multiple sclerosis. | 02-04-2016 |
20160027162 | METHOD AND SYSTEM FOR PROCESSING AN IMAGE - A method of processing an image having a plurality of picture-elements is disclosed. The method comprises: preprocessing the image to selectively enhance contrast of some picture-elements of the image, and employing a companding procedure for the preprocessed image, thereby providing a processed image. The contrast enhancement optionally and preferably features a mapping function having a plateau region for diminishing image data with intensity levels below an intensity threshold, thereby providing a preprocessed image. | 01-28-2016 |
20150363672 | METHOD AND SYSTEM OF CLASSIFYING MEDICAL IMAGES - A method of generating a category model for classifying medical images. The method comprises providing a plurality of medical images each categorized as one of a plurality of categorized groups, generating an index of a plurality of visual words according to a distribution of a plurality of local descriptors in each the image, modeling a category model mapping a relation between each visual word and at least one of the categorized groups according to the index, and outputting the category model for facilitating the categorization of an image based on local descriptors thereof. | 12-17-2015 |
20150315646 | METHODS OF PREDICTING CLINICAL COURSE AND TREATING MULTIPLE SCLEROSIS - Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency. | 11-05-2015 |
20150315253 | PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY, YDYNLY, FDYNFY, FDYNLY, FDYNWY, YDWNLY, YDWHLY and WDYNLY, extracted from organisms such as aquatic organisms and mossor any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface. | 11-05-2015 |
20150265210 | ASSESSMENT OF BLOOD-BRAIN BARRIER DISRUPTION - A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations. | 09-24-2015 |
20150259390 | PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface. | 09-17-2015 |
20150209078 | VERESS NEEDLE - A Veress needle includes an outer needle having a shaft and a sharp distal point. The sharp distal point and a distal portion of the shaft are configured to penetrate tissue. A spring-loaded, inner cannula is disposed in the outer needle. The cannula has a dull tip and a gas exit aperture is formed near a distal end of the cannula. The outer needle has an outwardly expandable portion located on the distal portion of the shaft. | 07-30-2015 |
20150182169 | METHODS AND DEVICES FOR PROVIDING INFORMATION USEFUL IN THE DIAGNOSIS OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT - Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities. | 07-02-2015 |
20150173897 | PROSTHETIC MITRAL VALVE - A prosthetic mitral valve with a frame comprises at least one arm shaped to deploy among a region of chordae tendineae of the native mitral valve to deflect these chords in order to pull the native valve leaflets around the frame to avoid paravalvular leaks. The frame may be made from two parts that are connected by sutures. The prosthetic valve may be deployed by a catherer comprising a deployment clamp attached to the valve frame where the deployment clamp is actuable to induce rotation of the frame. | 06-25-2015 |
20150173623 | METHODS AND DEVICES FOR PROVIDING INFORMATION USEFUL IN THE DIAGNOSIS OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT - Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities. | 06-25-2015 |
20150099665 | METHODS FOR DISTINGUISHING BETWEEN SPECIFIC TYPES OF LUNG CANCERS - The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers. | 04-09-2015 |
20140343435 | METHODS AND DEVICES SUITABLE FOR IMAGING BLOOD-CONTAINING TISSUE - Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm. | 11-20-2014 |
20140270451 | MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE - Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes. | 09-18-2014 |
20140243230 | GENE EXPRESSION SIGNATURE FOR CLASSIFICATION OF KIDNEY TUMORS - The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy. | 08-28-2014 |
20140235488 | MICRORNA PATTERNS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MELANOMA - The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof. | 08-21-2014 |
20140180129 | METHODS AND DEVICES SUITABLE FOR IMAGING BLOOD-CONTAINING TISSUE - Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm. | 06-26-2014 |
20140171733 | BODY PART REPOSITIONING APPARATUS AND METHOD - A device for manipulating a body part, comprises: a) an elongated guide instrument provided with a tip suitable to be positioned in close juxtaposition with a tissue at a desired location of the said body part; and b) a suction channel terminating in or near said tip. | 06-19-2014 |
20140155318 | PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface. | 06-05-2014 |
20140135609 | METHODS AND DEVICES FOR PROVIDING INFORMATION USEFUL IN THE DIAGNOSIS OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT - Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities. | 05-15-2014 |
20140120554 | ANTI CEACAM1 ANTIBODIES AND METHODS OF USING SAME - A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same. | 05-01-2014 |
20140086839 | QUINOLONE ANALOGS FOR TREATING AUTOIMMUNE DISEASES - Provided are methods of treating autoimmune diseases by administering to the subject a therapeutically effective amount of a quinolone compound such as 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide (CX-5461). Also provided are methods of monitoring efficiency of treatment of the quinolone compound by determining the expression level of at least one gene of the RNA polymerase I pathway. | 03-27-2014 |
20140023702 | METHOD OF TREATING RETINITIS PIGMENTOSA - Provided is a method for improving day photopic vision and/or cone-derived visual field and visual function in a subject suffering from a retinal disease or trauma including administering to the subject a pharmaceutically effective amount of crude | 01-23-2014 |
20140011280 | METHODS OF REPROGRAMMING RENAL CELLS - A method of reprogramming a differentiated renal cell towards a progenitor phenotype is disclosed. The method comprises up-regulating in the differentiated renal cell an expression of at least one pluripotency associated gene and/or at least one renal stem cell associated gene, thereby reprogramming the differentiated renal cell towards a progenitor phenotype. Cell populations generated thereby and uses thereof are also disclosed. | 01-09-2014 |
20130259198 | METHOD AND SYSTEM FOR ELECTRON RADIOTHERAPY - A radiotherapy system is disclosed. The radiotherapy system comprises an electron beam generator for generating an electron beam and a magnetic field generator for generating a magnetic field. In some embodiments of the present invention, the system further comprises a controller for controlling the electron beam and the magnetic field generators such that the electron beam is dynamically shifted and the magnetic field is dynamically redirected synchronously with the shifting. | 10-03-2013 |
20130253416 | SUBRETINAL DELIVERY OF THERAPEUTIC COMPOSITIONS - Disclosed are methods of subretinal delivery of therapeutic compositions to the eye of a mammal. Also disclosed are devices useful for the subretinal delivery of therapeutic compositions to the eye of a mammal. | 09-26-2013 |
20130218145 | SYSTEM AND METHOD FOR TREATING AN EYE - The invention provides a device for delivering electromagnetic radiation to a limbal area of an eye that transforms one or more beams of electromagnetic radiation that are incident on a first side into one or more emitted beams of the electromagnetic radiation where the one or more beams are arrayed in a cylindrical array, an array of one or more beams each beam having a cross sectional shape of a circular arc or an array comprising a beam having an annular cross section. The invention also provides a system for delivering electromagnetic radiation to the limbal area of an eye that includes one or more devices of the invention and a source of electromagnetic radiation. The system may be used in the treatment of glaucoma. | 08-22-2013 |
20130197060 | MICRORNA PATTERNS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MELANOMA - The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof. | 08-01-2013 |
20130150261 | BREATH ANALYSIS OF PULMONARY NODULES - The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages. | 06-13-2013 |
20130129810 | IRON OXIDE NANOPARTICLES FOR USE IN TREATING NON-INFECTIOUS INFLAMMATORY DISORDERS - In accordance with the present disclosure there are provided iron oxide nanoparticles for use in the treatment of non-infectious inflammatory disorders. Also provided by the present disclosure is a method of treatment of non-infectious inflammatory disorders making use of such particles, pharmaceutical compositions and kits comprising such particles | 05-23-2013 |
20130123761 | SYSTEM AND METHOD FOR TREATING AN EYE - A system and method are presented for use in delivering electromagnetic radiation to a limbal area of an eye, for example for treatment of glaucoma. The system includes an illumination unit, a beam shaping device and a control unit. The illumination unit includes a first source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having first optical properties to be delivered to the limbal area of a patient's eye to interact therewith and produce a desired effect, and a second source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having second optical properties. The beam shaping device when accommodated in an optical path of said first and second beams defines one or more regions along a path substantially aligned with a limbus of the patient's eye. The control unit is configured and operable for operating the illumination unit in first and second illumination modes, such that in the first illumination mode the second beam propagates towards said beam shaping device and upon identifying that the second beam illuminates the limbus, the second illumination mode is activated in which the first beam is directed via said beam shaping device to pass through said one or more regions along said path to thereby interact with the limbus. | 05-16-2013 |
20120189574 | METHODS FOR HEMATOPOIETIC PRECURSOR MOBILIZATION - Methods of modulating mobilization of cells from the bone marrow are provided. In a specific embodiment there is provided a method of increasing mobilization of hematopoietic precursors from the bone marrow to the peripheral blood in a subject in need thereof, the method comprising: (a) administering to the subject an agent which downregulates an activity or expression of a coagulation factor or an effector thereof; and (b) harvesting the hematopoietic precursors from the peripheral blood. | 07-26-2012 |
20120178699 | KLOTHO PROTEIN AND RELATED COMPOUNDS FOR THE TREATMENT AND DIAGNOSIS OF CANCER - Disclosed is the use of a klotho protein or related compounds (especially KL1 or KL1 analogue) for treatment, and especially treatment of cancer, alone or together with other active pharmaceutical ingredients such as chemotherapeutic agents. | 07-12-2012 |
20120172314 | Klotho Protein and Related Compounds for the Treatment and Diagnosis of Cancer - Disclosed is the use of a klotho protein or related compounds for the diagnosis and treatment of cancer, alone or together with other active pharmaceutical ingredients such as chemotherapeutic agents or hormone-regulating agents. | 07-05-2012 |
20120157344 | GENE EXPRESSION SIGNATURE FOR CLASSIFICATION OF KIDNEY TUMORS - The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy. | 06-21-2012 |
20120136209 | METHODS AND DEVICES FOR PROVIDING INFORMATION USEFUL IN THE DIAGNOSIS OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT - Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities. | 05-31-2012 |
20120127430 | System And Method For Objective Chromatic Perimetry Analysis Using Pupillometer - The present invention relates to a system, device and a method for objective visual field testing and in particular, to such a system and method in which provides objective chromatic perimetry test or color vision test using a pupillometer. | 05-24-2012 |
20120122122 | METHOD OF DIAGNOSING CANCER - A method of diagnosing cancer is provided. The method comprising determining a level of CEACAM1 on isolated peripheral blood lymphocytes (PBLs) of a subject in need thereof, wherein an upregulation of the level of CEACAM1 above a predetermined threshold is indicative of cancer in said subject. | 05-17-2012 |
20120029497 | Method and System for Monitoring Ablation of Tissues - A method of monitoring heat damage to a tissue during a heat ablation procedure is disclosed. The method comprising: providing images of the tissue, extracting at least one parameter being indicative of a biological response to heat, and using the parameter(s) for determining the heat damage to the tissue. | 02-02-2012 |
20120015870 | PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface. | 01-19-2012 |
20120014927 | METHODS AND KITS FOR DETERMINING PREDISPOSITION TO CANCER - Provided are methods and kits for determining predisposition to cancer by determining the presence or absence in a heterozygote form of the KLOTHO functional variant. Also provided are methods of designing treatment and treating cancer based on the increased predisposition to the cancer, and to determine the prognosis of a subject diagnosed with cancer. | 01-19-2012 |
20110311495 | ISOLATED POPULATIONS OF RENAL STEM CELLS AND METHODS OF ISOLATING AND USING SAME - Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells. | 12-22-2011 |
20110311494 | METHODS OF REPROGRAMMING RENAL CELLS - A method of reprogramming a differentiated renal cell towards a progenitor phenotype is disclosed. The method comprises up-regulating in the differentiated renal cell an expression of at least one pluripotency associated gene and/or at least one renal stem cell associated gene, thereby reprogramming the differentiated renal cell towards a progenitor phenotype. Cell populations generated thereby and uses thereof are also disclosed. | 12-22-2011 |
20110236405 | COAGULATION FACTOR MODULATION FOR CONTROLLING TRANSPLANT ORGAN SIZE - A method of modulating transplant organ size in a subject in need thereof is disclosed. The method comprising: (a) administering to the subject an agent capable of modulating an activity or expression of a coagulation factor or an effector thereof; and (b) transplanting the organ into the subject; thereby modulating the transplant organ size in the subject. | 09-29-2011 |
20110098554 | Monitoring of convection enhanced drug delivery - A method for determining a response of a tissue to a destructive treatment is disclosed. The method comprises providing magnetic resonance images of the tissue, and using the magnetic resonance images for determining the response of the tissue to the destructive treatment. Also disclosed is a method for monitoring convection during direct convective interstitial infusion using a pharmaceutical composition which comprises a therapeutic agent and an MRI contrast agent. | 04-28-2011 |
20110046071 | GLP-1 Receptor Agonists And Related Active Pharmaceutical Ingredients For Treatment Of Cancer - Disclosed are methods and compositions for increasing concentrations of GLP-1 receptor agonists in the body for the treatment of cancer, alone or together with other active pharmaceutical ingredients such as chemotherapeutic agents or hormone-regulating agents. | 02-24-2011 |
20100273172 | MICRORNAS EXPRESSION SIGNATURE FOR DETERMINATION OF TUMORS ORIGIN - The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy. | 10-28-2010 |
20100221348 | THERAPEUTIC USES OF DUNALIELLA POWDER - A method for treating a disease selected from diabetes mellitus and atherosclerosis, and a method for reducing triglycerides and/or increasing HDL cholesterol levels in the plasma of a subject. The method comprises administrating to a subject an effective amount of crude | 09-02-2010 |
20100173291 | METHODS AND KITS FOR DETECTING FETAL CELLS IN THE MATERNAL BLOOD - Provided is a method of identifying a trophoblast by detecting in cells of a biological sample, with the proviso that the biological sample does not comprise a placental tissue, expression of a trophoblast marker selected from the group consisting of an annexin IV, a cytokeratin-7, a cytokeratin-8 and a cytokeratin-19; and classifying cells exhibiting expression of the trophoblast marker as trophoblasts. Also provided are methods of detecting a pregnancy in a subject, isolating trophoblasts from biological samples and prenatally diagnosing a conceptus using the identified trophoblasts. | 07-08-2010 |
20100172842 | ASSESSMENT OF BLOOD-BRAIN BARRIER DISRUPTION - A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations. | 07-08-2010 |
20100150868 | Methods of Individually Optimizing Treatment for an Inflammation Associated Disease - A method of individually optimizing a treatment for an inflammation associated disease is provided. The method comprising contacting each of identical white blood cell samples of a subject in need thereof with a different pharmaceutical agent of a plurality of pharmaceutical agents for the inflammation associated disease, so as to allow elicitation of an anti-inflammatory activity in the white blood cell samples; assaying the anti-inflammatory activity in the white blood cell samples; and identifying a pharmaceutical agent of the plurality of pharmaceutical agents eliciting a strongest anti-inflammatory activity, the pharmaceutical agent being the individually optimized treatment for the inflammation associated disease, wherein when the inflammation associated disease is multiple sclerosis the white blood cell samples are inflamed white blood cell samples. Methods of treating an inflammation associated disease are also described. | 06-17-2010 |
20090298045 | Method For Selectively Expanding, Selecting And Enriching Stem/Progenitor Cell Populations - A method of producing stem/progenitor cells from human or animal origin. A population, from an embryonic, fetal or adult source, preferably from bone marrow, blood, fat, muscle, heart, intestine, kidney, liver, lung, pancreas, skin or neural tissues, that includes stem/progenitor cells, is treated with one or more first cytostatic or cytotoxic agents to which the stem/progenitor cells are less sensitive than the other cells of the population. Preferably, the agent(s) selectively deplete(s) from the population cells that are negative with respect to expressing a transporter gene of the first agent(s) while sparing cells that are positive with respect to expressing that gene. Preferably, the population also is treated with one or more cytokines and/or growth factors. | 12-03-2009 |