Teijin Pharma Limited Patent applications |
Patent application number | Title | Published |
20160039784 | PYRAZOLE DERIVATIVE - Provided are a compound expressed by formula (I) or a pharmacologically permissible salt thereof, as well as a drug or drug composition that contains this compound as an active ingredient, having a xanthine oxidase inhibiting effect that is very useful for treating or preventing diseases that are contributed to by xanthine oxidase, such as gout, hyperuricemia, tumor lysis syndrome, urinary tract stones, hypertension, dyslipidemia, diabetes, cardiovascular disease such as heart failure and arterial sclerosis, renal disease such as diabetic near opacity and the like, respiratory disease such as chronic obstructive pulmonary disease and the like, autoimmune diseases such as inflammatory bowel disease, and the like. [In the formula, A, X, Y, Z, R, and R | 02-11-2016 |
20160030763 | MAGNETIC STIMULATION DEVICE - Provided is a magnetic stimulation device, which does not feel hot to the user. The magnetic stimulation device ( | 02-04-2016 |
20160015588 | HEAD POSITIONING DEVICE, MEDICAL SYSTEM, MEDICAL INSTRUMENT POSITIONING DEVICE, AND HOLDING SHELL - Provided is an inexpensive device capable of accurately positioning a medical instrument relative to the head of a user. A head positioning device ( | 01-21-2016 |
20150376174 | AZOLE BENZENE DERIVATIVE - The present invention provides: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity on xanthine oxidase and is useful as a therapeutic agent or a prophylactic agent for diseases associated with xanthine oxidase, such as gout, hyperuricemia, tumor lysis syndrome, urinary tract stone, hypertension, dyslipidemia, diabetes, cardiovascular diseases including arteriosclerosis and heart failure, renal diseases including diabetic nephropathy, respiratory diseases including chronic obstructive pulmonary disease, inflammatory bowel disease or autoimmune diseases; and a medicine or a pharmaceutical composition comprising the compound or the salt as an active ingredient. | 12-31-2015 |
20150284358 | PYRIDINE DERIVATIVE - Provided is a pyridine derivative represented by formula (I), a prodrug thereof, a pharmaceutically acceptable salt of the pyridine derivative or the prodrug, or a solvate of the pyridine derivative, the prodrug or the pharmaceutically acceptable salt, which is useful for treatment or prophylaxis of diseases associated with URAT1 such as gout, hyperuricemia, hypertension, kidney diseases such as interstitial nephritis, diabetes, arteriosclerosis and Lesch-Nyhan syndrome. | 10-08-2015 |
20150274680 | THERAPEUTIC OR PROPHYLACTIC AGENT FOR TUMOR LYSIS SYNDROME - The purpose of the present invention is to provide a novel therapeutic or prophylactic agent for tumor lysis syndrome. The present invention is a therapeutic or prophylactic agent for tumor lysis syndrome, which comprises a 2-phenylthiazole compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. | 10-01-2015 |
20150217078 | OXYGEN CONCENTRATION DEVICE - An oxygen concentration device is provided which, when the number of revolutions of a compressor reaches an upper limit of control, increases an oxygen concentration, and can extend an operating time of the oxygen concentration device, comprising a control means which controls the number of revolutions of the compressor based on a detected value of an oxygen concentration sensor, judges deterioration due to moisture absorption based on the detected value of the oxygen concentration sensor, a detected value of a pressure sensor, and an operating time of an adsorption cylinder and, when criteria for judgment of the deterioration due to moisture absorption are satisfied, makes a purge step time shorter than an initially set time. | 08-06-2015 |
20150204318 | COMPRESSOR - Provided is a compressor as a device which can solve a contradictory technical problem of installing an intake sound muffler while downsizing the device under a circumstance that installation of the intake sound muffler is indispensable to reduce intake noise of the compressor, and the compressor comprises: a first lid part provided with a small hole which forms an intake port of the compressor, the lid part constituting a portion of a cylindrical casing of the compressor; a cylindrical part; and a second lid part which forms a small chamber together with the first lid part, wherein the second lid part is provided with a suction nozzle for sucking air into the small chamber. | 07-23-2015 |
20150183854 | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMENTIA | 07-02-2015 |
20150151020 | FORMED SHEET PRODUCT AND HEMOSTATIC MATERIAL - A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material. | 06-04-2015 |
20150148552 | 23-YNE-VITAMIN D3 DERIVATIVE - To provide a novel vitamin D | 05-28-2015 |
20150132279 | RADIATION STERILIZATION-RESISTANT PROTEIN COMPOSITION - A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization. | 05-14-2015 |
20150125511 | STERILE COMPOSITION - A sterile composition which comprises a protein and an aliphatic polyester containing the protein and is sterilized with radiation. In this sterile composition, the structure and function (activity) of the protein are retained. | 05-07-2015 |
20150065544 | THERAPEUTIC AGENT AND PREVENTIVE AGENT FOR DEMYELINATING DISEASE - The object of the present invention is to provide a novel therapeutic or preventive agent for demyelinating disease. The present invention is a therapeutic or preventive agent for demyelinating disease, containing as an active ingredient a 2-phenylthiazole compound represented by Formula (I) | 03-05-2015 |
20150038768 | TRANSCRANIAL MAGNETIC STIMULATION SYSTEM - A transcranial magnetic stimulation system has a magnetic field generating means for generating a variable magnetic field to be used for providing magnetic stimulation to a specific part of the patient's head. The system also has a holder for holding a magnetic coil of the magnetic field generating means, cameras for recognizing respective reference markings or specific portions of ears of the patient (tragi), and laser beam oscillators. According to the system, the coil is set in a proper posture with respect to the specific part of the patient by aligning the optical axes of the cameras and the laser beam oscillators with respective tragi. | 02-05-2015 |
20140343351 | TRANSCRANIAL MAGNETIC STIMULATION SYSTEM - A compact and economical transcranial magnetic stimulation system has a magnetic field generator for generating a magnetic field to be used for providing magnetic stimulation to the head of patient. The generator has a magnetic coil for generating a variable magnetic field and a holder for holding the magnetic coil. The holder has positioning portions for positioning the holder against respective markings on the head of patient. The coil is placed into a suitable posture against certain position by aligning the positioning portions with the markings on the head of patient. | 11-20-2014 |
20140242147 | ADSORBENTS FOR ORAL ADMINISTRATION - The present invention aims to provide an adsorbent for oral administration comprising ACF that has high adsorption or removal performance by adsorbing or removing toxic substances in the living body greatly and rapidly. The present invention is an adsorbent for oral administration comprising activated carbon fibers for treating or preventing kidney diseases or dialysis complications. | 08-28-2014 |
20140046114 | THERAPEUTIC ELECTROMAGNETIC STIMULATION DEVICE AND METHOD OF GENERATING CUSTOM DATA PAIRS USED IN SAID DEVICE - Provided is a therapeutic electromagnetic stimulation device for providing magnetic stimulation by applying a magnetic field to a specific site of an object person, the device including: a magnetic field generating means configured to generate one of a therapeutic magnetic field and a detection magnetic field for detection of information at least including positional information; magnetic field detecting means configured to detect intensities of components in a plurality of directions of one of the therapeutic magnetic field and the detection magnetic field at least at two detection positions; and a data generating means configured to generate custom data pairs for an individual object person, the custom data pairs being for deriving at least information of positions of the magnetic field generating means from the intensities of the corresponding components, the data generating means generating the custom data pairs using: (1) a sampling detection result of the detection of the intensities of the corresponding components in a state in which the magnetic field generating means are disposed respectively at a plurality of sampling spots near the specific site of the object person; and (2) a plurality of parent data pairs each including (a) at least information of a three-dimensional position of the magnetic field generating means pairing with (b) information of the intensities of the corresponding components of the magnetic field at a position having at least the information of the three-dimensional position, the information (a) and (b) being previously recorded. | 02-13-2014 |
20130210781 | 23-YNE-VITAMIN D3 DERIVATIVE - To provide a novel vitamin D | 08-15-2013 |
20130158272 | METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND - The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C | 06-20-2013 |
20130115287 | INTRAORALLY DISINTEGRATING TABLET - Disclosed is an orally disintegrating tablet which masks bitterness, dissolves well, and which permanently retains good oral disintegration properties immediately following manufacture. The disclosed orally disintegrating tablet is formed by compression-molding an organic acid together with particles comprising active ingredient-containing nuclear particles covered by a layer containing water-insoluble polymers and/or enteric polymers. | 05-09-2013 |
20130109726 | SUSTAINED-RELEASE THERAPEUTIC AGENT FOR HYPERTENSION AND RENAL DYSFUNCTION | 05-02-2013 |
20130101670 | FORMULATIONS COMPRISING COATED FINE PARTICLES - [OBJECT] To provide an intraorally rapidly disintegrating tablet comprising 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid as an active ingredient, which is a formulation that causes virtually no irritating sensation in the oral cavity or pharynx, and retains good dissolution and oral disintegration properties even when it is stored under high temperature/high humidity conditions. | 04-25-2013 |
20130089609 | CONTROLLED RELEASE NUCLEATED TABLET - Disclosed is a controlled release nucleated tablet which is composed of an inner nucleus and an outer layer that covers the inner nucleus and is capable of maintaining the level of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in the blood to a certain value or higher for a long period of time. The controlled release nucleated tablet is characterized in that the inner nucleus contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and the outer layer contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and a gel-forming water-soluble polymer that is in an amount of 16 (w/w) % or more relative to the weight of the outer layer. | 04-11-2013 |
20120291884 | OXYGEN CONCENTRATOR - The present invention provides an oxygen concentrator which allows the flow rate setting to be changed safely and securely by the patient using a remote control device, the oxygen concentrator comprising a control means which does not allow the operation of the flow rate setting change button unless the remote control device receives the information on the flow rate setting value of the oxygen-enriched gas supplied by the current oxygen concentrator main body. | 11-22-2012 |
20120272966 | OXYGEN ENRICHMENT DEVICE - Disclosed is an oxygen enrichment that can follow changes in adsorption performance in response to changes in the temperature of the usage environment and can reduce power consumption. The oxygen enrichment device has a purge step control means that controls a purge step time to increase/decrease the length of a purge step so as to maximize the oxygen concentration by changing opening/closing timing of a flow-channel switching means while the oxygen enrichment device is running. | 11-01-2012 |
20120130240 | ULTRASOUND DETECTING DEVICE HAVING FUNCTION OF CONFIRMING IRRADIATION POSITION, AND METHOD THEREOF - Provided is an ultrasound fracture detection device capable of accurately irradiating an ultrasound pulse to a target object, the device being characterized by being provided with an ultrasound wave irradiating transducer, a signal receiving transducer which receives a reflected wave of an ultrasound wave irradiated from the ultrasound wave irradiating transducer, a signal, storage unit which stores a received signal, and a display unit which displays an analysis program that analyzes a stored signal, a determination program that performs determination from the result of the analysis and/or performs determination from the stored signal, and the result of the analysis and/or the result of the determination, wherein the determination program performs the determination using that information relating to the received signal varies depending on the reflector within a living organism. | 05-24-2012 |
20120125337 | DEVICE FOR CALCULATING RESPIRATORY WAVEFORM INFORMATION AND MEDICAL INSTRUMENT USING RESPIRATORY WAVEFORM INFORMATION - Provided is a configuration capable of executing a detection test for a comfort level including the quality of sleep, which is measurable at home without requiring the measurement of brain waves or electrocardiogram. The respiratory waveform of a subject during sleep is continuously measured and recorded from the respiratory gas flow, etc., and is window-Fourier transformed at each measurement time to generate a frequency spectrum, and a bandwidth including a respiratory frequency is extracted. The index indicating the regularity of the respiratory period of the subject is also calculated at each time point during the sleep, and the time-dependency of this index during the sleep is represented as a graph. A medical device includes a sleep evaluation system equipped with a control means for performing control so that a sleep cycle repeated at a cycle of about 90 minutes is clearly observed if the comfort level including the quality of sleep of the subject is favorable. | 05-24-2012 |
20120108821 | PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECABOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD - Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent. | 05-03-2012 |
20120078013 | METHOD FOR PRODUCING 4-SUBSTITUTED BENZOTHIOAMIDE DERIVATIVE - Disclosed is a method appropriate for safely, economically and easily producing at a high yield a 4-substituted benzothioamide derivative which is useful as an intermediate in the production of a 2-(3-cyanophenyl)thiazole derivative useful as a drug for gout. Specifically disclosed is a method for producing a 4-substituted benzothioamide derivative represented by formula (A). | 03-29-2012 |
20120046467 | QUATERNARY AMMONIUM SALT COMPOUNDS | 02-23-2012 |
20110313169 | PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST - A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3). | 12-22-2011 |
20110306580 | PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DISEASE RESULTING FROM ABNORMAL BONE METABOLISM - The object of the present invention is to provide a therapeutic agent or a prophylactic agent for a disease resulting from an abnormal bone metabolism, especially osteoporosis which is more effective than conventional agents. Excellent therapeutic effect or prophylactic effect on a disease resulting from an abnormal bone metabolism, especially osteoporosis, compared with the effect in administration of each compound alone can be obtained by the combination of an N-hydroxybenzamidine derivative represented by Formula (I) or a salt thereof with an activated vitamin D or a prodrug thereof. | 12-15-2011 |
20110262998 | PROCESS FOR PREPARING INCLUSION BODY-FORMING PROTEIN - A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest, and a process for preparing an inclusion body-forming protein consisting of the following steps: (1) preparing an expression vector in which a nucleic acid fragment is incorporated consisting of a nucleotide sequence coding for a modified signal peptide downstream of which is bound a nucleotide sequence of a gene of a protein of interest, (2) preparing a host cell transformed with the expression vector that produces an inclusion body-forming protein, and (3) purifying the inclusion body-forming protein from culture obtained by culturing the host cell that produces the inclusion body-forming protein. The above other amino acid is selected from the group consisting of aspartic acid, glutamic acid, lysine, histidine, phenylalanine and tyrosine. | 10-27-2011 |
20110247627 | WEARING TOOL FOR BREATHING MASK, AND BREATHING MASK - For reducing a discomfort feeling brought by wearing a breathing mask, a wearing tool for the breathing mask which covers nostrils of a user and supplies gas for breathing to the nostrils comprises a pair of connecting members each of which has a longitudinal shape and has a first end portion which is connected to the breathing mask, and a pair of fixing members each of which is connected to a second end portion of the fixing member and is plugged in the tragus of the user. Hence a discomfort feeling due to restraining around the head of the user can be reduced. | 10-13-2011 |
20110207944 | VITAMIN D3 LACTAM DERIVATIVE - Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R | 08-25-2011 |
20110110949 | NESFATIN-1 SPECIFIC ANTIBODY AND THE USE THEREOF, AND NESFATIN SPECIFIC ANTIBODY AND THE USE THEREOF - The present application relates to an antibody performing an antigen-antibody reaction with Nesfatin-1, but not substantially performing the antigen-antibody reaction with Nesfatin and/or NucB1, and with the use of the antibody, an immunological detection method and a detection kit of Nesfatin-1, and further, an antibody performing an antigen-antibody reaction with Nesfatin, but not substantially performing the antigen-antibody reaction with NucB1, and an immunological detection method using the antibody, and a detection kit of Nesfatin comprising the antibody. | 05-12-2011 |
20110046192 | THERAPEUTIC DRUG FOR HYPERTENSION OR PREHYPERTENSION - The present invention relates to a therapeutic drug or a preventive drug for hypertension or high-normal blood pressure, comprising (a) and (b) as active ingredients:
| 02-24-2011 |
20100317836 | NOVEL BIOLOGICAL SUBSTANCE NESFATIN AND ITS RELATED SUBSTANCES AND USES THEREOF - The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and/or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and/or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. | 12-16-2010 |
20100242734 | OXYGEN CONCENTRATOR - The present invention provides an apparatus which stably provides highly concentrated oxygen to a patient, regardless of an environmental temperature and/or a highly concentrated oxygen gas flow rate. The present invention is an oxygen concentrator characterized in that an oxygen concentration sensor detecting a concentration of the oxygen gas produced by the oxygen concentrator, a temperature sensor measuring an environmental temperature and/or a flow rate sensor are provided, a control increasing/decreasing a supply airflow volume of the compressed air supply device based on a detected oxygen concentration detected value to maintain an oxygen concentration at a predetermined concentration is performed, and a control device is switched based on a value measured by the temperature sensor and/or flow rate sensor of the apparatus. | 09-30-2010 |
20100216747 | PREVENTIVE AGENT OR THERAPEUTIC AGENT FOR DISEASE CAUSED BY ABNORMAL BONE METABOLISM - An object of the present invention is to provide a preventive drug and a therapeutic drug for diseases caused by abnormal bone metabolism, especially osteoporosis, which is more effective than conventional drugs. Combined use of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or a salt thereof; and at least one compound selected from the group consisting of etidronic acid, clodronic acid, pamidronic acid, tiludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and salts thereof can exert higher bone resorption inhibitory effect and provide a preventive effect and a therapeutic effect for diseases caused by abnormal bone metabolism, especially osteoporosis as compared with administration of the respective agents respectively. | 08-26-2010 |
20100168574 | Medical Ultrasound Device Having Irradiation Position Checking Function - The present invention is a medical ultrasound device in which an ultrasound pulse is irradiated to a treatment or examination region, provided with ultrasound-wave irradiating means, signal receiving means for receiving a reflected wave of the ultrasound irradiated from the ultrasound irradiating means, signal recording means (memory) for recording a received signal, and comparing means (comparison operation element) for comparing a recorded signal and the received signal. By the device of the present invention, an appropriate treatment or examination position can be checked with high reproducibility. | 07-01-2010 |
20100126249 | ULTRASONIC APPARATUS AND METHOD FOR MEASURING THE CONCENTRATION OF GAS - In an ultrasonic apparatus for measuring the concentration of gas provided with two ultrasonic oscillators for transmitting/receiving an ultrasonic wave, arranged opposite to each other in piping through which a sample gas flows, a temperature sensor, and a pressure sensor, an ultrasonic method and apparatus that can accurately measure gas concentration regardless of pressure of the sample gas are provided as an ultrasonic apparatus for measuring the concentration of gas comprising concentration calculating means for calculating sample gas concentration based on a propagation speed correction coefficient by pressure. | 05-27-2010 |
20100125059 | 1-BIARYLAZETIDINONE DERIVATIVE - The object of the present invention is to provide a compound having an excellent cholesterol-lowering effect and to provide a drug for the treatment, prevention of onset, or prevention of progress of lipid metabolism disorder, hyperlipidemia, or atherosclerosis. | 05-20-2010 |
20100092596 | TABLET COMPRESSION MACHINE - A tablet compression machine which can manufacture a tablet having a plurality of layers by applying secondary compression molding to a columnar primary compression molded product formed by a plurality of layers and whose two bottom faces may be bulged, comprising at least a mortar, an upper pestle, and a lower pestle, in which the mortar is substantially in a shape in which a part of a flat plate is punched by a closed curve in a direction perpendicular to a plane of the flat plate, the upper and lower pestles are in a shape fitted with an inner face of the mortar, a space formed by an inner face of the mortar, a lower face of the upper pestle, and an upper face of the lower pestle is in a shape of an intended tablet in the secondary compression molding, a dent formed by the inner face of the mortar and the upper face of the lower pestle can constitute a shape suitable for receiving the primary compression molded product, and a direction of the secondary compression molding is different from the compression molding direction of the primary compression molded product. According to such a tablet compression machine, a multilayer tablet in a shape having a multilayer structure and not limited to columnar can be manufactured. | 04-15-2010 |
20100071698 | OXYGEN CONCENTRATOR - The present invention relates to an oxygen concentrator in which a pulsation detection device for detecting pulsation of oxygen supplied and a control device for controlling an amount of air supplied from a compressor based on the detection results in a pressure swing adsorption-type oxygen concentrator, which is equipped with an adsorption bed filled with an adsorbent capable of selectively adsorbing nitrogen relative to oxygen, the compressor for supplying air to the adsorption bed, a channel switching valve to repeat in a constant timing an adsorption step, in which air is supplied from the compressor to the adsorption bed to isolate concentrated oxygen and a desorption step, in which the adsorption bed is evacuated to regenerate the adsorbent and a flow rate measuring device for determining a supply flow rate of concentrated oxygen produced and an amount of oxygen produced is controlled by a feedback with a flow rate sensor by itself after paying attention to variation of a product flow rate caused by suppressing an amount of oxygen produced, thereby realizing an apparatus to satisfy secondary performance such as miniaturization, low power consumption and silencing. | 03-25-2010 |
20100068707 | METHOD FOR SCREENING FOR VITAMIN D RECEPTOR LIGANDS - The present invention relates to a screening method for a compound and includes a step of detecting binding between a vitamin D receptor and CDP. A novel method enabling screening in vitro of a compound having strong bone forming action and low side effects, a compound participating in osteoblast differentiation and selected by the method of screening, a therapeutic agent containing the compound for diseases intervening in the increase in vitamin D-mediated transcriptional activity by a complex of a vitamin D receptor and CDP, and a kit for performing the screening method are provided. | 03-18-2010 |
20100043800 | Nasal respiratory mask system - A light weight nasal respiratory mask system securing airtightness of a mounting section between a nasal mask and a frame is provided. | 02-25-2010 |
20100012128 | RESPIRATORY MASK SYSTEM - A respiratory mask system is provided, in which while wearing a respiratory mask system, force generated by movement of a user's head and the like to induce laterally slipping a mask cushion may be reduced or absorbed. | 01-21-2010 |
20100009004 | INTRAORALLY RAPIDLY DISINTEGRATING TABLET - The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity. | 01-14-2010 |
20090299074 | BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION - The invention provides benzo[b]thiophene derivatives useful as production intermediates for chymase inhibitors, and a process for their production. | 12-03-2009 |
20090291945 | CYSTEINE PROTEASE INHIBITORS - To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis, osteoarthritis, chronic rheumatoid arthritis, Paget's disease of bone, hypercalcemia, bone metastasis of cancer, and ostealgia. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, or a drug or pharmaceutical composition containing the same as an effective component. | 11-26-2009 |
20090288180 | NOVEL PROTEIN AND PRODUCTION PROCESS AND USE THEREOF - [Problems] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. | 11-19-2009 |
20090281445 | Oxygen concentrating apparatus and execution support method of home oxygen therapy using the same - In order to enable a medical worker to certainly and easily know whether a patient on a home oxygen therapy, who continues to inhale an oxygen-enriched gas at home, performs the inhalation as prescribed, a history of a supply condition of the oxygen-enriched gas supplied to the patient is recorded and held as supply history information, this supply history information is compared with a prescription of the oxygen therapy of the patient to generate patient's compliance information to indicate the degree to which the oxygen therapy is performed in accordance with the prescription, the oxygen concentrating apparatus is constructed to be portable, and a doctor can confirm the patient's compliance information at the time of going to a medical institution regularly. | 11-12-2009 |
20090250065 | HEADGEAR AND ITS MANUFACTURING METHOD - A headgear suitable for wearing a respiratory mask system wearing on the head of a user is provided, wherein it can be easily manufactured, the leakage of the positive pressure gas when pressurized is reduced, and a good wearing feel is achieved. The headgear is adapted to secure a respiratory mask, which contacts the face of the user to supply a positive pressure gas for respiration to the user, to the head of user. The headgear has a head mounted portion which is worn on the occipital of the user and a strap ( | 10-08-2009 |
20090233325 | SCREENING METHOD OF NESFATIN-1-ACTION REGULATING SUBSTANCE OR NESFATIN-1-LIKE ACTION SUBSTANCE WITH THE USE OF RECEPTOR PROTEIN SELECTED FROM THE GROUP CONSISTING OF GPR3, GPR6 AND GPR12 - An object of the present invention is to identify a Nesfatin-1 receptor, and to provide a method for screening or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action substance using the Nesfatin-1 receptor. | 09-17-2009 |
20090187062 | Fixture of the Head for Transcranial Magnetic Stimulation and Transcranial Magnetic Stimulator - A transcranial magnetic stimulator according to the present invention includes fixing means for detachably fixing a magnetic field generating means and contains a fixture of a head which covers a head of an examinee to be fixed engaged with a shape of the head that is inherent to an examinee; and characterized in that: a relative position of the magnetic field generating means with respect to the head of the examinee is held constant so that the highest point of an intensity of an electric current to be induced by a magnetic field to be generated by the magnetic field generating means is constantly arranged on a target spot of a diameter not more than 10 mm, which depends on each of the examinees and is located within a cranium, by fixing the magnetic field generating means to the fixing means and a direction of a magnetic field to be generated by the magnetic field generating means and a direction of the target spot are made into a fixed relation. | 07-23-2009 |
20090173343 | Nasal Respiratory Mask System and Connection/Disconnection Means Used Therein - The present invention relates to a nasal respiratory mask system comprising: a nasal mask that is tightly attached to the face of a user and serves as means for leading positive-pressure breathing gas to the nose of the user, a frame to keep the nasal mask at a predetermined position, and a headgear that is mounted on the head in order to attach the nasal mask tightly to the face; wherein, the headgear comprises, on the tip thereof, a headgear strap for adjusting the length of the headgear, the headgear strap comprises a headgear fastener that serves as means for connection/disconnection with the frame, the frame comprises a fastener catch that engages with the headgear fastener, and the fastener catch comprises an axisymmetric guide whose (rotation) axis is the insertion direction of the headgear fastener. The present invention provides a nasal respiratory mask system with which a headgear can be easily connected at the beginning of wearing, twisting of the headgear during wearing is prevented, and disassembly upon daily washing is easy. | 07-09-2009 |
20090155833 | SCREENING METHOD OF NESFATIN-1-ACTION REGULATING SUBSTANCE OR NESFATIN-1-LIKE ACTION SUBSTANCE WITH THE USE OF RECEPTOR PROTEIN SELECTED FROM THE GROUP CONSISTING OF GPR3, GPR6 AND GPR12 - An object of the present invention is to identify a Nesfatin-1 receptor, and to provide a method for screening or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action substance using the Nesfatin-1 receptor. | 06-18-2009 |
20090117182 | INTRAORALLY RAPIDLY DISINTEGRATING TABLET - The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity. | 05-07-2009 |
20090110726 | FORMULATION HAVING ACCURATE DOSE-DIVIDING FUNCTION - The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions. | 04-30-2009 |
20090076120 | Crystal of Aminopyrrolidine Derivative and Production Method Thereof - Two crystal forms of (R)-3-[2-(2-amino-5-trifluoromethoxybenzamido)acetamido]-1-(6-methylindol-3-ylmethyl)pyrrolidine which exhibit specific X-ray powder diffraction patterns or infrared absorption spectra, amorphous form thereof, a pharmaceutical composition containing the crystal or amorphous form as an active ingredient, as well as methods for preparing them are provided. | 03-19-2009 |
20090071341 | Rotary-Valve and Adsorption Separation System - A rotary valve comprising sliding members for supplying treatment gas containing water vapor to a plurality of treatment processes is provided. The rotary valve comprises sliding members ( | 03-19-2009 |
20090054472 | Pyrazolopyrimidine Derivatives or Pharmaceutically Acceptable Salts Thereof - A pyrazolopyrimidine derivative represented by formula (1) and pharmaceutically acceptable salt thereof exhibit excellent inhibitory activity against MAPKAP-K2. Accordingly, medicines containing this compound as an active ingredient are expected to be effective for treating diseases mediated by MAPKAP-K2 such as, for example, inflammatory disorder, autoimmune diseases, destructive osteopathy, cancer and/or tumor growth. | 02-26-2009 |
20090025564 | Silencer and oxygen concentrator having silencer - Provided are an expansion-type silencer ( | 01-29-2009 |
20090025560 | Oxygen Concentrator - The present invention provides a pressure swing adsorption-type oxygen concentrator for medical use having a flow channel switching device that successively pressurizes and supplies air from an air supply device at a constant timing to adsorb/desorb nitrogen in the air, wherein the flow channel switching device is a rotary distributor valve assembly structure provided with an electric motor, the rotary distributor valve assembly structure being provided with a shaft seal mechanism to perform shaft sealing with an O-ring having Shore A hardness of 45 to 60 degree and further the oxygen concentrator has a mechanism that simultaneously achieves rotary drive transmission following axial offset and angular offset of the rotary shaft of the rotary distributor valve assembly structure and shaft sealing. | 01-29-2009 |
20090014008 | Nasal Respiration Mask - According to the present invention, there is provided a nasal respiratory mask contacting with the face of a user for supplying respiratory positive-pressure gas to the nose of the user, comprising at least a part attached tightly to the face that is attached tightly to the face of the user; a frame-fitting part for fitting to a frame; and an elastic connecting part that connects elastically the part attached tightly to the face with the frame-fitting part, wherein a facial side of the elastic connecting part is kept apart from the frame-fitting part side thereof for a required distance even in the absence of applied respiratory positive pressure. | 01-15-2009 |