Technion Research & Development Foundation Limited Patent applications |
Patent application number | Title | Published |
20160074425 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS - A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: | 03-17-2016 |
20160032271 | ENCAPSULATION OF BACTERIA AND VIRUSES IN ELECTROSPUN FIBERS - A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 μm within which distinct organisms are encapsulated in viable form. | 02-04-2016 |
20150352136 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS - A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders. | 12-10-2015 |
20150337289 | METHODS AND DEVICES FOR MANIPULATION OF TARGET CELLS USING A COMBINED APPLICATION OF ACOUSTICAL AND OPTICAL RADIATIONS - A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern. | 11-26-2015 |
20150328283 | NOVEL ANTIMICROBIAL AGENTS - A novel class of antimicrobial polymeric agents, which include a plurality of positively charged amino acid residues and at least one omega-amino-fatty acid residue linking therebetween, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same. | 11-19-2015 |
20150322272 | HYDROPHOBIC AND OLEOPHOBIC SURFACES AND USES THEREOF - A methodology is provided for generating hydrophobic superhydrophobic, oleophobic and/or superoleophobic surfaces. Compositions of matter made of a substrate having deposited on a surface thereof (e.g., by thermal evaporation) hydrocarbon waxes, including fluorinated waxes, are disclosed. Process of preparing such compositions of matter and articles of manufacturing incorporating such compositions are also disclosed. Further disclosed are articles of manufacturing and methods which are useful in inhibiting, reducing and/or retarding biofilm formation, and which include applying waxes (e.g., by thermal evaporation) on a surface of the articles. | 11-12-2015 |
20150252326 | METHODS OF EXPANDING EMBRYONIC STEM CELLS IN A SUSPENSION CULTURE - A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention. | 09-10-2015 |
20150240202 | CULTURE MEDIA, CELL CULTURES AND METHODS OF CULTURING PLURIPOTENT STEM CELLS IN AN UNDIFFERENTIATED STATE - Provided are novel serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3 and ascorbic acid at a concentration of at least about 50 microgram/ml; ascorbic acid at a concentration range of about 400-600 microgram/ml, bFGF at a concentration range of about 50-200 ng/ml, xeno-free serum replacement and a lipid mixture; the IL6RIL6 chimera at a concentration range of about 50-200 picogram per milliliter (pg/ml); or leukemia inhibitory factor (LIF) at a concentration of at least 2000 units/ml; cell cultures comprising same with pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems; and methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation. | 08-27-2015 |
20150216812 | USE OF DECELLULARIZED EXTRACELLULAR MATRIX FOR ENCAPSULATING CELLS - A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM). | 08-06-2015 |
20150118750 | COMPOSITIONS CAPABLE OF SPECIFICALLY BINDING PARTICULAR HUMAN ANTIGEN PRESENTING MOLECULE/PATHOGEN-DERIVED ANTIGEN COMPLEXES AND USES THEREOF - A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed. | 04-30-2015 |
20150033872 | MICROFLUIDIC PLATFORM AND METHODS FOR USING THE SAME - The present invention provides a microfluidic device which includes at least 3 chambers, a chamber inlet, at least 2 dichotomously branching generations of channels, a channel inlet, and a channel outlet, wherein the channels and the chambers are separated by deformable walls, wherein each wall is lined with at least one cavity, and wherein the cavity is fluidly connected to the channel. | 02-05-2015 |
20150011896 | VESSEL IMAGING SYSTEM AND METHOD - A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image. | 01-08-2015 |
20140313315 | METHOD AND SYSTEM FOR TRANSMITTING LIGHT - A temporal focusing system is disclosed. The temporal focusing system is configured for receiving a light beam pulse and for controlling a temporal profile of the pulse to form an intensity peak at a focal plane. The temporal focusing system has a prismatic optical element configured for receiving the light beam pulse from an input direction parallel to or collinear with the optical axis of the temporal focusing system and diffracting the light beam pulse along the input direction. | 10-23-2014 |
20140244687 | PROCESSING QUERY TO GRAPH DATABASE - A method of processing a query to a graph database using a plurality of processors. The method comprises providing a plurality of threads to be executed on a plurality of processors, each the thread is associated with one of a plurality of unique thread identifiers, providing a graph database having a plurality of graph database nodes and a plurality of graph database edges, each the graph database edge represents a relationship between two of the plurality of graph database nodes, receiving a query tree that defines a tree comprising plurality of query nodes connected by a plurality of query tree edges, and searching at least part of the graph database for a match with the query tree, wherein the searching is executed by the plurality of the processors, and wherein each the processor searches one of a plurality of sub-graphs of the graph database, each the sub-graph is defined by one of the plurality of thread identifiers. | 08-28-2014 |
20140214736 | TRAINING ENSEMBLES OF RANDOMIZED DECISION TREES - A method training a randomized decision tree through multiple iterations, each is based on:
| 07-31-2014 |
20140206448 | CONTROL OF INTERACTIONS WITHIN VIRTUAL ENVIRONMENTS - A method for restricting the number of consequential interactions to further virtual objects having a relationship with a first virtual object, resulting from an interaction with said first virtual object. The method comprises: defining a maximum number of consequential interactions, counting consequential interactions, and stopping further interaction when the maximum number of consequential interactions is reached. | 07-24-2014 |
20140200204 | COMBINATIONS OF CORROLES AND STATINS - Embodiments of the invention relate to methods of treatment a cardiovascular disease in a patient comprising administering an effective amount of a statin or a pharmaceutically acceptable salt thereof in combination with an effective amount of a transition metal complex of a corrole, an optically active isomer thereof or a pharmaceutically acceptable salt thereof. Further embodiments refer to pharmaceutical compositions comprising a statin and a corrole. | 07-17-2014 |
20140142332 | PROCESS OF PREPARING GRIGNARD REAGENT - A novel process of preparing a Grignard reagent is disclosed. The process is effected by electrochemically reacting a Grignard precursor with an electrode which comprises a metal for forming the Grignard reagent, in the presence an electrolyte solution that comprises a room temperature ionic liquid (RTIL). Electrochemical cells and systems for performing the process, and uses thereof in various applications are also disclosed. | 05-22-2014 |
20140119628 | IMAGE RECONSTRUCTION IN COMPUTED TOMOGRAPHY - A method of projection domain processing based on a local transform and shrinkage for use in reconstructing digital images from a set of projections, the method including providing a target image of a target object, providing projection data of the target object, producing filtered projection data by applying a sparsifying transform and a shrinkage function to the projection data, followed by an inverse of the sparsifying transform, producing a restored image by applying a reconstruction transform to the filtered projection data, comparing the restored image to the target image, and producing an optimized projection domain shrinkage function by adapting the shrinkage function to minimize differences between the restored image and the target image. Related apparatus and methods are also described. | 05-01-2014 |
20140113927 | TREATMENT UTILIZING HYDROPHOBIC WEAK BASES CHEMOTHERAPEUTIC AGENTS AND ILLUMINATION - Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination. | 04-24-2014 |
20140046408 | METHOD AND SYSTEM FOR OPTICAL STIMULATION OF NEURONS - A method of stimulating neurons present in a living body is disclosed. The method comprises directing light to an artificial light absorbing medium implanted extracellularly at a target location having the neurons therein, wherein wavelengths and intensities of the light are selected so as to heat the light absorbing medium by light absorption. The heating is sufficient to stimulate neurons nearby the light absorbing medium. In some embodiments, the light is spatially modulating so as to encode a stimulation pattern therein. | 02-13-2014 |
20140045266 | METHODS OF CULTURING CELLS IN A MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR - The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells. | 02-13-2014 |
20140012851 | APPARATUS AND METHOD FOR INCREMENTAL PHYSICAL DATA CLUSTERING - In a data storage and retrieval system wherein data arranged in nodes is stored and retrieved in pages, each page comprising a cluster of nodes, a method comprising: monitoring ongoing data retrieval to find retrieval patterns of nodes which are retrieved together and to identify changes in said retrieval patterns over time; and periodically reclustering the data nodes among said pages dynamically during usage of the data to reflect said changes, so that nodes more often retrieved together are migrated to cluster together and nodes more often required separately are migrated to cluster separately, thereby to keep small an overall number of page accesses of said data storage and retrieval system during data retrieval despite dynamic changes in patterns of data retrieval. The low number of page accesses allows the reclustering to be carried out concurrently with data access. | 01-09-2014 |
20140010850 | ALBUMIN FIBERS AND FABRICS AND METHODS OF GENERATING AND USING SAME - Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue. | 01-09-2014 |
20130324627 | SHAPE-MEMORY STRUCTURES - Polymeric foams and elastomer/hydrogel bicontinuous composite structures derived from high internal phase emulsions and possessing shape-memory characteristics are disclosed, as well as processes for forming the same and uses thereof in, for example, manufacturing of various articles. | 12-05-2013 |
20130252329 | MEDIA FOR CULTURING STEM CELLS - Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of mainataining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells. | 09-26-2013 |
20130251692 | METHODS OF GENERATING CORNEAL CELLS AND CELL POPULATIONS COMPRISING SAME - A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof. | 09-26-2013 |
20130237489 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS - A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: | 09-12-2013 |
20130236961 | NOVEL METHODS AND CULTURE MEDIA FOR CULTURING PLURIPOTENT STEM CELLS - Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4 | 09-12-2013 |
20130226966 | PROCESSING A HIERARCHICAL STRUCTURE TO RESPOND TO A QUERY - A method of processing of processing a hierarchical structure to respond to a query, comprising:
| 08-29-2013 |
20130216400 | METHOD AND SYSTEM FOR GENERATING MECHANICAL WAVES - A system for generating a mechanical wave is disclosed. The system comprises a camshaft having plurality of rotatable cams, serially mounted on a shaft along an axis of an elastic tubular shell to form a varying phase angle along the shaft. The system further comprises a plurality of cam followers arranged circumferentially about each cam, such that a rotary motion of the cams generates a linear motion of the cam followers to radially bias in internal wall the shell. The variation of the phase angle is selected to generate a three-dimensional traveling wave along the shell. | 08-22-2013 |
20130202669 | ALBUMIN FIBERS AND FABRICS AND METHODS OF GENERATING AND USING SAME - Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue. | 08-08-2013 |
20130130387 | METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS FROM KERATINOCYTES DERIVED FROM PLUCKED HAIR FOLLICLES - A method for generating induced pluripotent stem (iPS) cells from isolated hair follicles is disclosed. The method comprises:
| 05-23-2013 |