President and Fellows of Havard College Patent applications |
Patent application number | Title | Published |
20150301023 | CELL BASED QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS - A method for determining the translation initiation inhibitory potency of a composition having an unknown level of translation initiation inhibitory activity which comprises contacting an eI-F2α-WT cell with said composition for a time and at a temperature effective to inhibit proliferation of said cell, measuring the level of inhibition of proliferation of said eIF2α-WT cells induced by said sample and comparing the level of inhibition of proliferation induced by said sample with the level of inhibition of proliferation induced by a standard having a known amount of said activity, the amount of said translation initiation inhibitory activity in said sample being proportional to the level of inhibition of proliferation of said eIF2α-WT cell. | 10-22-2015 |
20120267549 | METHODS AND APPARATUS FOR FLUORESCENCE SENSING EMPLOYING FRESNEL ZONE PLATES - Methods and apparatus for high-throughput fluorescence detection using integrated microfabricated optical element arrays are described. In one example, the optical element arrays may comprise one or more microfabricated Fresnel zone plates, which may be configured to collect light from samples flowing in microfluidic channels. Multiple samples may be inspected in parallel at significantly high rates (e.g., about 200,000 samples per second or higher). A relay lens combined with high numerical aperture integrated microfabricated optical elements provides significant signal enhancement (e.g., on the order of at least 200 times that of conventional fluorescence detection methods). | 10-25-2012 |
20110315229 | FLUID DELIVERY SYSTEM AND METHOD - A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process. | 12-29-2011 |
20110190141 | Evolving New Molecular Function - Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis. | 08-04-2011 |
20100304994 | Oligonucleotide Paints - Novel methods for making high resolution oligonucleotide paints are provided. Novel, high resolution oligonucleotide paints are also provided. | 12-02-2010 |
20100152057 | HIGH-SENSITIVITY NANOSCALE WIRE SENSORS - The present invention generally relates to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample. The invention provides a nanoscale wire that has improved sensitivity, as the carrier concentration in the wire is controlled by an external gate voltage, such that the nanoscale wire has a Debye screening length that is greater than the average cross-sectional dimension of the nanoscale wire when the nanoscale wire is exposed to a solution suspected of containing an analyte. This Debye screening length (lambda) associated with the carrier concentration (p) inside nanoscale wire is adjusted by adjusting the gate voltage applied to an FET structure, such that the carriers in the nanoscale wire are depleted. | 06-17-2010 |
20090004852 | Nanostructures Containing Metal Semiconductor Compounds - A network element ( | 01-01-2009 |