| New York University Patent applications |
| Patent application number | Title | Published |
|---|
| 20220296604 | INDOLE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF - Indole compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, schemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity. | 09-22-2022 |
| 20220288384 | ELECTRICAL INHIBITION (EI) UTERINE PACEMAKER FOR CONTROLLING UTERINE CONTRACTIONS - In an aspect of the present disclosure, a system and method for controlling uterine contractions is disclosed including receiving data from at least one sensor by a wireless apparatus inserted into the patient's vagina adjacent the cervix. The data includes an indication that a contraction of the uterus is imminent. The method further includes in response to receiving the data, causing a generator circuit of the wireless apparatus to supply electrical energy to an energy applicator of the wireless apparatus that is configured to apply the supplied electrical energy to the uterus of the patient via the cervix of the patient to control contractions of the patient's uterus. | 09-15-2022 |
| 20220249869 | METHOD TO SELECT RADIATION DOSAGE FOR TUMOR TREATMENT BASED ON CELLULAR IMAGING - Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information. | 08-11-2022 |
| 20220244830 | Sensor Having a Set of Plates, and Method - A sensor having a set of plates, each having a sensing element, of a grid of wires disposed on a base, and a top surface layer that is disposed atop the set of plates, so that force imparted from above onto the top surface layer is transmitted to the plates and thence to the grid of wires. The sensor includes a computer in communication with the grid which causes prompting signals to be sent to the grid and reconstructs a continuous position of force on the surface from interpolation based on data signals received from the grid. A method for sensing. | 08-04-2022 |
| 20220229119 | SYSTEMS AND METHODS FOR MAGNETIC SUSCEPTOMETRY OF DEVICES WITH MAGNETOMETRY - A method of diagnosing internal characteristics of a device includes applying a strong magnetic field to the device. The method can include reducing the strong magnetic field at a location of one or more sensors. At least one of the one or more sensors is proximate to the device. The method can include measuring induced magnetic fields around the device. The method can include measuring induced or intrinsic electrical current flow. The method can include measuring intrinsic magnetic properties. The induced magnetic fields can include diagnostic information on properties of the device and how the properties change over time. The device may be, for example, a battery, a capacitor, a supercapacitor, or a fuel cell. The presented measurement of magnetic susceptibility can be performed on materials, solutions, chemical substances, or tissue samples. | 07-21-2022 |
| 20220204480 | CRYSTALLINE FORMS OF IMIDACLOPRID AND METHODS OF USE THEREOF - The present invention relates to crystalline polymorphs of imidacloprid for effective pest management strategies at lower dosages. The present invention further relates to processes of preparing the crystalline polymorphs, and to methods of controlling pests using the novel crystalline polymorphs. | 06-30-2022 |
| 20210393739 | THERAPEUTIC AND COSMETIC USES AND APPLICATIONS OF CALRETICULIN - The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion. | 12-23-2021 |
| 20210392421 | SOUND SENSING SYSTEM - An outdoor sound sensing system ideal for homes and buildings equipped with windows called the sound sensing system. The sound sensing system consists of a two-sided printed circuit board with a microphone module, a lightweight sticker, and a cable system that connects the printed circuit board to a sound recording and processing module. The printed circuit board has an aperture aligned to an acoustic shield to provide protection from the environment for the microphone module. The lightweight sticker has an aperture that is also aligned to the acoustic shield. | 12-16-2021 |
| 20210364403 | COLLOIDAL FINGERPRINTS FOR SOFT MATERIALS USING TOTAL HOLOGRAPHIC CHARACTERIZATION - Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes. | 11-25-2021 |
| 20210361603 | METHODS OF TREATING CANCERS HAVING A DEREGULATED NRF2/KEAP1 PATHWAY - The present disclosure relates to a method of treating a subject having cancer that includes selecting a subject having cancer associated with a deregulated NRF2/KEAP1 pathway and administering to the selected subject one or more inhibitors comprising a glutamine transporter inhibitor; a GPD2 inhibitor; or combination(s) thereof. | 11-25-2021 |
| 20210340188 | RECOMBINANT GP120 PROTEIN WITH V1-LOOP DELETION - Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject. | 11-04-2021 |
| 20210335493 | SYSTEM TO DETECT DIELECTRIC CHANGES IN MATTER - Systems and methods for detecting dielectric changes in matter are provided. The system includes a data collection array to collect microwave scattering data and a machine learning device. The machine learning device is configured to receive the microwave scattering data, patient information, and imaging modality data corresponding to at least one of a presence of disease, absence of disease, or one or more disease features; analyze the microwave scattering data, patient information, and imaging modality data; output at least one of a predicted disease state and predicted features based on the analyzed microwave scattering data, patient information, and imaging modality data; compare the imaging modality data corresponding to the at least one of a presence of disease, absence of disease, or one or more disease features to the predicted disease state or predicted features; and use the comparison as an input into the machine learning device. | 10-28-2021 |
| 20210332429 | METHODS, PROCEDURES AND KITS FOR PROVIDING MAXIMUM DEPTH ENRICHMENT SEQUENCING FOR IDENTIFICATION FOR ENRICHMENT OF RARE GENOMIC VARIANTS - Exemplary embodiments of methods, kits, systems and computer-accessible medium can be provided for facilitating maximum depth enrichment sequencing for identifying rare genomic variants. | 10-28-2021 |
| 20210330205 | APPARATUS, COMPUTER-ACCESSIBLE MEDIUM, SYSTEM AND METHOD FOR DETECTION, ANALYSIS AND USE OF FETAL HEART RATE AND MOVEMENT - Exemplary embodiments of the present invention provide for an apparatus, computer-accessible medium, system and method for detection, analysis and use of fetal heart rate and movement. In accordance with certain exemplary embodiments of the present disclosure, an exemplary system can include: at least one electrocardiogram sensor providing first signals or information regarding the at least one subject; a plurality of inertial measurement units providing second signals or information regarding the at least one subject; a plurality of acoustic sensors providing third signals or information regarding the at least one subject; and a processor, wherein the processor is configured to determine data regarding the fetal heart rate based on the first, second and third signals or information. | 10-28-2021 |
| 20210321955 | METHODS AND KITS FOR ASSESSING NEUROLOGICAL AND OPHTHALMIC FUNCTION AND LOCALIZING NEUROLOGICAL LESIONS - A method for detecting, diagnosing or screening for concussion in a subject includes a) tracking eye movement of at least one eye of the subject, b) analyzing eye movement of at least one eye of the subject, c) calculating a statistical test for eye movement of at least one eye of the subject as compared to a normal or mean eye movement, and d) detecting, diagnosing or screening for an impairment based on the calculated statistical test. | 10-21-2021 |
| 20210198349 | Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy - The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions. | 07-01-2021 |
| 20200120583 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR POWER MEASUREMENT FOR MMWAVE CELLULAR SYSTEM - An exemplary system, method and computer-accessible medium for determining a particular base station to connect to by a mobile phone can include, for example, receiving a first synchronization signal from a first base station, where the first synchronization signal can include a first antenna gain correction and a first power allocation correction for the first base station, receiving a second synchronization signal from a second base station, where the second synchronization signal can include a second antenna gain correction and a second power allocation correction for the second base station, and determining whether the first base station or the second base station is the particular base station to connect to by comparing the first synchronization signal to the second synchronization signal. | 04-16-2020 |
| 20200118307 | SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR GENERATING MAGNETIC RESONANCE IMAGING-BASED ANATOMICALLY GUIDED POSITRON EMISSION TOMOGRAPHY RECONSTRUCTION IMAGES WITH A CONVOLUTIONAL NEURAL NETWORK - An exemplary system, method and computer-accessible medium for generating an image(s) of a portion(s) of a patient(s) can be provided, which can include, for example, receiving first information associated with a combination of positron emission tomography (PET) information and magnetic resonance imaging (MRI) information, generating second information by applying a convolutional neural network(s) (CNN) to the first information, and generating the image(s) based on the second information. The PET information can be fluorodeoxyglucose PET information. The CNN(s) can include a plurality of convolution layers and a plurality of parametric activation functions. The parametric activation functions can include, e.g., a plurality of parametric rectified linear units. Each of the convolution layers can include, e.g., a plurality of filter kernels. The PET information can be reconstructed using a maximum likelihood estimation (MLE) procedure to generate a MLE image. | 04-16-2020 |
| 20200113951 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING PANCREATIC CANCERS - The application relates to methods based on modulating mammalian intestinal and/or pancreatic microbiota and related probiotic, prebiotic, and anti-bacterial compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma. | 04-16-2020 |
| 20200090814 | PROCESS, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR GENERATING A BIOLOGICAL MODEL ASSOCIATED WITH DISEASE - The present disclosure relates to exemplary embodiments of method, computer-accessible medium, system and software arrangements for, e.g., Cancer Hallmark Automata, a formalism to model the progression of cancers through discrete phenotypes (so-called hallmarks). The precise computational model described herein includes the automatic verification of progression models (e.g., consistency, causal connections, etc.), classification of unreachable or unstable states (e.g., “anti-hallmarks”) and computer-generated (individualized or universal) therapy plans. Exemplary embodiments abstractly model transition timings between hallmarks as well as the effects of drugs and clinical tests, and thus allows formalization of temporal statements about the progression as well as notions of timed therapies. Certain exemplary models discussed herein can be based on hybrid automata (e.g., with multiple clocks), for which relevant verification and planning algorithms exist. | 03-19-2020 |
| 20200086110 | ELECTRICAL INHIBITION (EI) UTERINE PACEMAKER FOR CONTROLLING PRETERM UTERINE CONTRACTIONS AND PRETERM BIRTH - In an aspect of the present disclosure, a system and method for controlling uterine contractions is disclosed including receiving data from at least one sensor by a wireless apparatus inserted into the patient's vagina adjacent the cervix. The data includes an indication that a contraction of the uterus is imminent. The method further includes in response to receiving the data, causing a generator circuit of the wireless apparatus to supply electrical energy to an energy applicator of the wireless apparatus that is configured to apply the supplied electrical energy to the uterus of the patient via the cervix of the patient to control contractions of the patient's uterus. | 03-19-2020 |
| 20190315841 | Antibody-Based Molecules Specific for the Truncated ASP421 Epitope of Tau and Their Uses in the Diagnosis and Treatment of Tauopathy | 10-17-2019 |
| 20190280791 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR SIMULATION AND EMULATION OF WIRELESS CLUSTER AND/OR TAPPED DELAY LINE MODELS | 09-12-2019 |
| 20190271677 | METHODS AND KITS FOR DETECTING NON-LUMINESCENT OR WEAKLY LUMINESCENT METALS - The invention provides methods and kits for detecting the presence of, the amount of, or the concentration of a substantially non-emitting metal in a sample by a) providing a sensitizer to a chelator of the substantially non-emitting metal thereby creating a sensitized-metal complex; b) adding an unsensitized chelate, and c) detecting a signal from the unsensitized chelate. The substantially non-emitting metal may be gadoliniumn and may exist in complex with a chelator. The unsensitized chelate may be terbium (Tb) or europium (Eu) and the detecting a signal may be performed by fluorescence. | 09-05-2019 |
| 20180156807 | METHOD FOR TREATING HIGH-GRADE GLIOMAS - The invention is directed to a method for inhibiting growth, self-renewal, or tumorigenicity of glioma cells and a method for treating high-grade gliomas by inhibiting GPR133 expression and/or function in glioma cells, including CD133+ glioma stem cells (GSCs). | 06-07-2018 |
| 20170259204 | Fluid Separation Processes Using Membranes Based on Fluorinated and Perfluorinated Polymers - A process for separating components or a fluid mixture using membranes comprising a selective layer made from copolymers of an amorphous per fluorinated dioxolane and a fluorovinyl monomer. The resulting membranes have superior selectivity performance for certain fluid components of interest while maintaining fast permeance compared to membranes prepared using conventional perfluoropolymers, such as Teflon® AF, Hyflon® AD, and Cytop®. | 09-14-2017 |
| 20170160793 | Foot Operated Navigation and Interaction for Virtual Reality Experiences - An apparatus for creating movement in a virtual reality for a user includes a computer includes a virtual reality headset in communication with the computer that is worn on the head of the user so the user sees the virtual reality shown by the headset and produced by the computer in the headset. The apparatus includes a foot controller in communication with the computer against which the user moves at least one of his feet to create control signals with the foot to cause movement in the virtual reality. A method for creating movement in a virtual reality for a user having the steps of the user seeing the virtual reality shown by a virtual headset and produced by a computer in the headset, a virtual reality headset in communication with the computer that is worn on the head of the user. There is the step of the user moving at least one of his feet against a foot controller to create control signals with the foot to cause movement in the virtual reality by the computer, the foot controller in communication with the computer. A computer software program for creating movement in a virtual reality for a user. | 06-08-2017 |
| 20170151290 | COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS BY CHARACTERIZING AND RESTORING MAMMALIAN BACTERIAL MICROBIOTA - The present invention relates to characterizing changes in mammalian intestinal microbiota associated with associated with high-fat and low-fat diets and with diets containing hydroxypropylmethylcellulose (HPMC) and related methods for diagnosing, preventing and treating obesity and related conditions such as metabolic syndrome and diabetes mellitus. Therapeutic methods of the invention involve the use of probiotics, and/or prebiotics, and/or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial intestinal microbiota. | 06-01-2017 |
| 20170044099 | COVALENTLY PATTERNED GRAPHENE SURFACES BY A FORCE ACCELERATED CYCLOADDITION REACTION | 02-16-2017 |
| 20170042904 | METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA | 02-16-2017 |
| 20170020674 | REPLICA GUIDED MOTION KNEE - A total knee replacement, comprising a femoral and a tibial component in articulating contact that can restore normal joint function. The articulation between the two components is controlled by four guide surfaces. | 01-26-2017 |
| 20160331792 | METHODS FOR RESTORING MICROBIOTA OF NEWBORNS - The invention relates to methods and compositions for restoring normal microbiota in pre-term newborns or newborns delivered by Cesarean section and methods for preventing or ameliorating diseases associated with delivery by Cesarean section or pre-term birth comprising administering to said newborns at the time of birth or shortly thereafter an effective amount of a vaginal microbiota inoculum obtained from the newborn's mother or a donor or an effective amount of a probiotic composition. | 11-17-2016 |
| 20160302146 | SWITCHED ANALOG-DIGITAL ARCHITECTURE FOR WIRELESS ANTENNA ARRAYS AND METHODS FOR USE THEREOF | 10-13-2016 |
| 20160298198 | METHOD FOR PREDICTING DEVELOPMENT OF MELANOMA BRAIN METASTASIS | 10-13-2016 |
| 20160297802 | CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS | 10-13-2016 |
| 20160296608 | TREATMENT METHODS USING ATOXIC NEUROTOXIN DERIVATIVES | 10-13-2016 |
| 20160187258 | SYSTEMS AND METHODS FOR OXYGEN SENSING - An oxygen sensing system comprises a substrate structured to communicate optical signals. An oxygen sensing layer is disposed on the substrate and comprises an oxygen sensing molecule in a matrix in a first unexcited state and formulated to: (a) be excited by a first optical signal to move to a second state; (b) be quenched in the second state by oxygen; and (c) emit a second optical signal corresponding to an amount of oxygen. A protective layer is disposed on the oxygen sensing layer. The protective layer includes at least one of i) an oleophobic layer configured to protect the oxygen sensing layer from hydrocarbons and organic solvents and ii) an anti-fouling layer configured to protect the oxygen sensing layer from biofouling. A controller is optically coupled to the substrate and structured to generate the first optical signal, receive the second optical signal and determine oxygen concentration from the second optical signal. | 06-30-2016 |
| 20160183553 | MERINGUE COMPOSITION AND METHODS OF PREPARATION - A meringue composition is disclosed, which may be prepared without the inclusion of egg or egg byproduct material as an ingredient. The meringue is prepared from a mixture consisting essentially of saponin, a sugar or sugar substitute, and water. The meringue is capable of being prepared to a self-sustaining, baked product. The final meringue product may be prepared by a variety of heating methods, including microwave heating. Further, the nature of the final product may be controlled by the extent of heating, so that a product more flowable or creamy may be achieved by a reduction in the heating time. The meringue of the invention is suitable for strict vegetarians (‘vegans’) and individuals who are allergic to eggs and egg bi-products. | 06-30-2016 |
| 20160159866 | CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE - The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins. | 06-09-2016 |
| 20160144229 | MODULAR MULTI-JOINT REHABILITATION TRAINING SYSTEM AND METHOD - The present invention relates to a device or apparatus for aiding in upper extremity rehabilitation treatment. The apparatus is a portable mobile rehabilitation device which has first and second arms attached to the central fulcrum of a tabletop platform which is supported by a height adjustable side pillar and base piece. Each arm has 3 links or segments attached at the ends by detachable and adjustable rotating support which are termed as joints. The distal end of each arm has an end-effector which is a hand hold module that is attached to the distal part of the subject arm. The proximal end of each arm is attached to the central fulcrum. The arms along with the modules will provide support for the patient to move the arm at different joints either by passive movement or active assist movement. | 05-26-2016 |
| 20160138018 | ANTI-miR-27b AND ANTI-miR-148a OLIGONUCLEOTIDES AS THERAPEUTIC TOOLS FOR TREATING DYSLIPIDEMIAS AND CARDIOVASCULAR DISEASES - The present invention relates to anti-miR-27b and anti-miR-148a oligonucleotides that are capable of decreasing the level and/or activity of miR-27b and miR-148a, respectively. In conjunction with the oligonucleotide molecules of the present invention, the invention also provides a method for decreasing the level and/or activity of miR-27b and/or miR-148a in a cell. In a further embodiment, the invention provides a method for treating a disease, especially dyslipidemias and cardiovascular diseases. | 05-19-2016 |
| 20160122757 | siRNA TARGETING HSR1 - The invention provides siRNA molecules and LNA antisense oligonucleotides, which target Heat Shock RNA (HSR1) and effectively inhibit stress response in a cell, and their use for treatment of various diseases. | 05-05-2016 |
| 20160120915 | METHODS FOR MANIPULATING IMMUNE RESPONSES BY ALTERING MICROBIOTA - The present invention relates to characterizing changes in mammalian microbiota associated with antibiotic treatments and various immunological conditions and related therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, synbiotics, and antibiotics. | 05-05-2016 |
| 20160120860 | METHODS AND AGENTS FOR TREATING TYROSINASE-POSITIVE ALBINISM - Methods for treating a subject with tyrosinase-positive albinism; agents and compositions thereof for use in treating tyrosinase-positive albinism; and medicaments for treating tyrosinase-positive albinism are described herein. Such methods; agents and compositions thereof; and medicaments relate to chloroquine or rapamycin or compositions thereof and may further relate to nitisinone used in conjunction with the chloroquine or rapamycin or a composition of either of which. | 05-05-2016 |
| 20160106400 | ENDOSCOPIC SIDE RELEASE BIOPSY VALVE - A biopsy valve for an endoscope includes a valve body that is laterally divided into an upper portion having a first height and a lower portion having a second height, a through hole provided along a central, longitudinal axis of the valve body, and a tab disposed between the upper portion of the valve body and the lower portion of the valve body. The upper portion and the lower portion are hingedly connected such that the upper portion is configured to rotate about a hinge and move relative to the lower portion, which is generally stationary. The upper portion is biased in a closed position in which suction is maintained in the endoscope. Exerting an upward or a downward force on the tab rotates the upper portion about the hinge into an open position in which suction is released in the endoscope. | 04-21-2016 |
| 20160077591 | HAPTIC FORCE-FEEDBACK FOR COMPUTING INTERFACES - Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, for receiving, from an accelerometer, angle information of a device. A calibration position is measured based upon the angle information of the device when the device is at rest. A current position is constantly measured based upon the angle information of the device. A current pressure is calculated based upon the current position and the calibration position. The current pressure can be used to augment an audio signal and/or used to augment an audio instruction. | 03-17-2016 |
| 20160068263 | FLAPPING WING DEVICE - A flapping wing device may include a main body and several wings hingedly coupled to the main body. The wings may be configured to reciprocate or “flap” relative to the main body to provide lift for the flapping wing device. A motor and trans mission, such as a crankshaft, are used to drive the reciprocating motion of the wings. The wings reciprocate from a first position that is substantially vertically parallel to the main body of the device to a second position in which a second end, opposite the hinged end, extends away from the main body. The motion of the reciprocating wings may be reminiscent of the motion of a jellyfish. In some instances, a first set of opposing or alternating wings may be reciprocated at an offset period relative to a second set of opposing or alternating wings, such as a quarter period offset. | 03-10-2016 |
| 20160067136 | GAME-BASED SENSORIMOTOR REHABILITATOR - Treatment of neurological injury through motor relearning. A game-based sensorimotor rehabilitator that enables individuals to interact with the functional objects using the appropriate amount of force, tilt, finger movement, and muscle activity to regain lost skill due to injury. | 03-10-2016 |
| 20160054262 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING GENERALIZED LOCAL MAXWELL TOMOGRAPHY FOR MAPPING OF ELECTRICAL PROPERTY GRADIENTS AND TENSORS - Exemplary system, method, and computer-accessible medium can be provided for determining at least one property (e.g., an electrical property or a cross-section property) of at least one target. For example, it is possible to determine electromagnetic-field-related quantities associated with signals provided from the target(s). The electromagnetic-field-related quantities can be provided to procedures to relate the electromagnetic-field-related quantities to a plurality of unknown electrical property values and residual field-related unknown values of the target(s). The property(ies) of the target(s) can be determined by determining the plurality of unknown electrical property values and residual field-related unknown values of the target(s). | 02-25-2016 |
| 20160051954 | HIGHER ORDER MULTIPLE EMULSIONS - Multiple emulsions with an “onion” topology are useful vehicles for drug delivery, biochemical assays, and templating materials. They can be assembled by ternary liquid phase separation using microfluidics, but the control over their design is limited because the mechanism of their creation is unknown. Here it is shown that phase separation occurs via self-similar cycles of mass transfer, spinodal decomposition or nucleation, and coalescence into multiple layers. Mapping out the phase diagram demonstrates a linear relation between concentric layer diameters, whose slope depends on the initial ternary composition and the molecular weight of the surfactant. These general rules quantitatively predict the number of droplet layers (multiplicity). Further, self-assembly routes for polymer capsules and liposomes are provided with techniques to assemble lipid-stabilized droplets with ordered internal structures. | 02-25-2016 |
| 20160042508 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING AND/OR DETERMINING MESOSCOPIC STRUCTURE AND ORIENTATION WITH FIBER TRACKING - Exemplary systems, methods, and computer-accessible mediums can be provided that can generate resultant data regarding fiber tract(s) and anatomical structure(s). For example, first information related to imaging data of the anatomical structure(s) can be received. Second information related to a predictive model of further fiber tract(s) can be received. The resultant data can be generated based on the first information, the second information and a fiber cost procedure. | 02-11-2016 |
| 20160035401 | PRECESSIONAL MAGNETIZATION REVERSAL IN A MAGNETIC TUNNEL JUNCTION WITH A PERPENDICULAR POLARIZER - A magnetic device that includes a perpendicular magnetized polarizing layer configured to provide a first spin-torque and an in-plane magnetized free layer having a magnetization vector having at least a first stable state and a second stable state. The magnetic device also includes a reference layer configured to provide a second spin-torque. The first spin-torque and the second spin-torque can combine. The in-plane magnetized free layer and the reference layer form a magnetic tunnel junction and the combined first spin-torque and second spin-torque influences the magnetic state of the in-plane magnetized free layer. An application of a voltage pulse, having either positive or negative polarity and a selected amplitude and duration, through the magnetic device causes the magnetization vector to oscillate between the first stable state and the second stable state for a portion of the duration regardless of an initial state of the magnetization vector. | 02-04-2016 |
| 20160033850 | COMMON-PATH NONCOLLINEAR OPTICAL PARAMETRIC AMPLIFIER - Systems and methods for providing a noncollinear optical parametric amplifier (NOPA). Two approaches for classes of NOPA are described: phase-mask NOPA and Wollaston NOPA. | 02-04-2016 |
| 20160032360 | A METHOD FOR A SINGLE CELL ANALYSIS OF TELOMERE LENGTH - The invention relates to a method for single cell analysis of relative telomere length using multiplex pre-PCR followed by a qPCR (SCT-pqPCR). | 02-04-2016 |
| 20160015376 | ANCHORED SUTURE LINE, DEVICE AND METHOD FOR SURGICAL SUTURING - Anchored suture line (ASL), comprising a suture thread upon which is located a plurality of anchor structures permanently attached to said suture thread at predetermined intervals, may be advantageously employed for surgical suturing procedures. An ASL suturing device may be employed to sequentially implant the anchors, still tethered to the suture line. As they are implanted, the anchors expand thereby becoming secured in the tissue. The process may be repeated without cutting the suture line until the wound is sealed. | 01-21-2016 |
| 20150381782 | HANDPHONE - A handphone is configured to receive a first audio signal of a telecommunication conversation from a telecommunication device and send a second audio signal of the telecommunication conversation to the telecommunication device. A modulated ultrasound frequency audio signal that is directional is created from the first audio signal of the telecommunication conversation. The modulated ultrasound frequency audio signal is output via a loudspeaker. A direction of the modulated ultrasound frequency audio signal is controlled by a physical object and a location of the loudspeaker. | 12-31-2015 |
| 20150370398 | Mechanical Force Redistribution Sensor Array Embedded in a Single Support Layer - An MFR sensor array having a first supporting layer. The array has a second supporting layer. The array has a force sensing component disposed between the first and second supporting layers. The array has protrusions combined with the force supporting component, where there are only two supporting layers. When a force is applied to the second supporting layer, the force causes the second supporting layer to contact protrusions so the force is transmitted through the protrusions to the force supporting component and through the force supporting component. An MFR sensor array. A system for sensing. A method for sensing. | 12-24-2015 |
| 20150368328 | Immunotherapy for Clearing Pathological Tau Conformers - The present invention relates to methods of treating and preventing Alzheimer's Disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent Alzheimer's Disease of other tauopathies. Also disclosed are methods of promoting clearance of from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject. | 12-24-2015 |
| 20150367038 | FABRICATION OF NANOWIRES AND HIERARCHICALLY POROUS MATERIALS THROUGH SUPERCRITICAL CO2 ASSISTED NEBULIZATION - A processing technique for creating nanowires and hierarchically porous micro/nano structures of ceramic materials is provided. The process includes evaporation of micron-sized water droplets containing dissolved organic salts on heated substrates followed by thermal decomposition of the deposited material. The micron-sized droplets may be generated by supercritical CO | 12-24-2015 |
| 20150365408 | SECURE TRANSACTIONS USING ALPHACODES - Systems and method for sending a first alphacode to a first participant over a secure channel. Sending a second alphacode to a second participant over a secure channel. Receiving a first encoded message, a second encoded message, and a plaintext message. The first encoded message is based on the first alphacode and the second encoded message is based on the second alphacode. Generating a first ciphertext based on the first alphacode and the plaintext message. Comparing the first ciphertext to the first encoded message and determining the authenticity of the first encoded message based at least on the comparing to the first ciphertext. Comparing the second ciphertext to the second encoded message and determining the authenticity of the second encoded message based at least on the comparing to the second ciphertext. Sending a first confirmation to the first participant and sending a second confirmation to the second participant. | 12-17-2015 |
| 20150359076 | METHODS FOR AFFECTING SPINNING ATMOSPHERIC PHENOMENA - A system and method for misbalancing or suppressing spinning atmospheric phenomena such as tornadoes, landspouts, waterspouts, gustnadoes and whirlwinds. The systems and methods misbalance or suppress such phenomena utilizing electromagnetic fields; irradiation; neutralizing charges; or chemical reactions, thus destabilizing or disrupting the phenomenon. | 12-10-2015 |
| 20150357015 | Current Induced Spin-Momentum Transfer Stack With Dual Insulating Layers - A high speed, low power method to control and switch the magnetization direction of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a pinned magnetic layer, a reference magnetic layer with a fixed magnetization direction and a free magnetic layer with a changeable magnetization direction. The magnetic layers are separated by insulating non-magnetic layers. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, can be measured to read out the information stored in the device. | 12-10-2015 |
| 20150356147 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUMS FOR UTILIZING PATTERN MATCHING IN STRINGOMES - Exemplary systems, methods and computer-accessible mediums can receive first data related to at least one first string arranged in a directed acyclic graph, compress the first data into second data, and can search the second data for a match of at least one second string. A node of the directed acyclic graph can encode at least one substring, and an edge of the directed acyclic graph can encode instructions for concatenating substrings. | 12-10-2015 |
| 20150355298 | METHOD AND DEVICE FOR ACCURATE QUANTIFICATION OF T2 RELAXATION TIMES BASED ON FAST SPIN-ECHO NMR SEQUENCES - A method and a device are provided that improve quantification of the spin-spin relaxation (“T | 12-10-2015 |
| 20150352526 | SELF ASSEMBLED PARTICLES - A self-assembling structure using non-equilibrium driving forces leading to “living crystals” and other maniputable particles with a complex dynamics. The dynamic self-assembly assembly results from a competition between self-propulsion of particles and an attractive interaction between the particles. As a result of non-equilibrium driving forces, the crystals form, grow, collide, anneal, repair themselves and spontaneously self-destruct, thereby enabling reconfiguration and assembly to achieve a desired property. | 12-10-2015 |
| 20150335262 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR THE PROBABILISTIC DETERMINATION OF NORMAL PRESSURE HYDROCEPHALUS - Exemplary systems, methods, and computer-accessible mediums can be provided for determining a probability or a presence of a disease(s), which can include, for example, receiving information related to an image(s) of a brain of a patient(s), and determining the probability or the presence of the disease(s) in the patient(s) based on ventricular volume and gray matter of the brain. The disease can be normal pressure hydrocephalus or Alzheimer disease. The determining procedure can be based on the probability, which can be based on a prediction model(s). The prediction model can be a multinomial regression model. The image can be a magnetic resonance image of the brain of the patient(s | 11-26-2015 |
| 20150333700 | AGGREGATED SPIN-TORQUE NANO-OSCILLATORS - A nano-oscillator magnetic wave propagation system has a group of aggregated spin-torque nano-oscillators (ASTNOs), which share a magnetic propagation material. Each of the group of ASTNOs is disposed about an emanating point in the magnetic propagation material. During a non-wave propagation state of the nano-oscillator magnetic wave propagation system, the magnetic propagation material receives a polarizing magnetic field. During a wave propagation state of the nano-oscillator magnetic wave propagation system, each of the group of ASTNOs initiates spin waves through the magnetic propagation material, such that a portion of the spin waves initiated from each of the group of ASTNOs combine to produce an aggregation of spin waves emanating from the emanating point. The aggregation of spin waves may provide a sharper wave front than wave fronts of the individual spin waves initiated from each of the group of ASTNOs. | 11-19-2015 |
| 20150328032 | SMART KNEE FIXTURE AND SYSTEM FOR MEASURING KNEE BALANCING - A Smart Knee Fixture (SKF) is a system comprising sensors, exciters and computation and command controllers that instrument the characterization of anatomical knee balance. Specifically the instrumentation allows the measurement of the relationship between varus-valgus angular response and a measured side force moment. | 11-19-2015 |
| 20150323616 | LONGEVITY OF HYPERPOLARIZED ENHANCED SIGNALS FOR +Hu 1 +l H NMR SPECTROSCOPY - A method and system for providing an article of manufacture with increased longevity of hyperpolarized | 11-12-2015 |
| 20150320334 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR IMPROVING PATIENT COMPLIANCE DURING MAGNETIC RESONANCE IMAGING EXAMINATIONS - An exemplary system, method and computer-accessible medium can be provided for alerting a patient of a condition(s) during an MRI scan procedure(s), which can include, for example receiving information related to the condition(s), and controlling an intensity of a light source(s) located near or on an MRI scanner based on the condition(s). The light source(s) can include a light-emitting diode, which can be a white LED and/or a rainbow LED. The color of the rainbow LED can be changed based on the condition(s). The light source(s) can be located inside or outside a bore of the MRI scanner. | 11-12-2015 |
| 20150309132 | APPARATUS, METHOD AND COIL ARRAY FOR PROVIDING SPLIT PARALLEL TRANSMISSION MAGNETIC RESONANCE IMAGING - An exemplary coil arrangement can be provided that can include a lateral coil array(s) configured to transmit a set of tailored pulses, and a contralateral coil array(s) configured to transmit the pulses. The lateral coil array(s) and the contralateral coil(s) array can be substantially identical. The pulses can include a set of radio frequency tailored pulses. The lateral coil array(s) and the contralateral coil array(s) can be further configured to transmit a radio frequency shim. A radio frequency shield can be included which can he associated with one of the arrays, and can be located between medial coils. The set of tailored pulses can be parallel pulses. The coil arrangement can be configured to be used at at least about 7 Tesla. The lateral coil array(s) can include at least 2 lateral coils. The contralateral coil array(s) can include at least 2 contralateral coils. | 10-29-2015 |
| 20150306441 | EXERCISE GARMENT WITH ERGONOMIC AND MODIFIABLE RESISTANCE BANDS - A garment that generates resistance against body movement that can be used during exercise, during everyday activities, or during rehabilitation therapy. The garment includes bands providing resistance against the movement of an associated limb. The garment includes a structure to secure the garment to a user during activity. | 10-29-2015 |
| 20150294597 | SOMATOSENSORY FEEDBACK WEARABLE OBJECT - Disclosed are systems, computer-readable mediums, and methods for receiving, from a sensor array, three-dimensional sensory data associated with an environment of a person. The three-dimensional sensory data is converted into a two-dimensional representation. An obstacle is located within the environment based upon the sensory data. The obstacle is mapped onto the two-dimensional representation and the two-dimensional representation is mapped onto a plurality of actuators within a vibrotactile interface. One or more of a plurality of actuators are controlled based upon the mapping of the two-dimensional representation onto the plurality of actuators to provide tactile input to the person that represents a location of the obstacle. | 10-15-2015 |
| 20150290611 | COLLOIDS WITH VALENCE: FABRICATION, FUNCTIONALIZATION AND DIRECTIONAL BONDING - A method and articles of manufacture for creating colloidal clusters and functionalized patchy particles. The method includes selecting at least one type of colloidal particle, functionalizing a patch of the colloidal particle and mixing a plurality of the colloidal particles to construct a cluster with particular desired geometries properties based on the bonding of the colloidal particles by virtue of the patch having bond-type characteristic analogous to, but not limited to atomic orbitals and other symmetries. | 10-15-2015 |
| 20150285878 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR SPECTROSCOPIC LOCALIZATION USING SIMULTANEOUS ACQUISITION OF DOUBLE SPIN AND STIMULATED ECHOES - Method, system and non-transitory computer-accessible medium can be provided for performing magnetic resonance spectroscopy for at least one structure. For example, with such method and/or computer-accessible medium, it is possible to receive information related to a substantially simultaneous acquisition of a stimulated echo pathway and a double spin echo associated with at least one portion of the at least one structure. | 10-08-2015 |
| 20150283512 | MICROFABRICATED ION-SELECTIVE FILTER FOR FILTRATION OF IONS AND MOLECULES - A microfabricated filtration membrane including a substrate containing a plurality of micropores, an ion-selective layer, and at least two conductive layers configured to apply a voltage across the micropores. The geometry of the conductive layers matches the geometry of the micropores (or nanopores). | 10-08-2015 |
| 20150278414 | STRUCTURAL WEAK SPOT ANALYSIS - A system and methods for weak spot analysis. A mesh shape is preprocessed to approximate an input model for an object. The mesh shape is analyzed with modal analysis to identify weak regions. A method and system for determining weak spots in an object. The method and system uses an optimization problem which is solved to determine a pressure distribution on the object maximizing maximal principal stress by solving a set of optimization problems maximizing stress for each point of the object. | 10-01-2015 |
| 20150274814 | METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS - The present invention relates to methods and compositions for preventing and treating | 10-01-2015 |
| 20150269594 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR CUSTOMER ACQUISITION USING SOCIAL TARGETING - Exemplary systems, methods and computer accessible medium can be provided for customer acquisition using social targeting can receive first information regarding at least one customer user associated with a particular node, determine second information based, at least in part, on the first information, receive third information regarding at least one non-customer user associated with the particular node, and determine fourth information based, at least in part, on the second information and the third information. | 09-24-2015 |
| 20150251225 | WATER COLLECTION AND CLEANING - Systems and methods for fluid harvesting and surface cleaning. A fluid harvesting device comprises a harvester having a hydrophobic surface and a collection device, adjacent the harvester, which receives fluid from the surface of the harvester. | 09-10-2015 |
| 20150245139 | ENVIRONMENTAL ANALYSIS - An environmental analysis system and method. Remote sensing devices detect nonvisual information. One or more loudspeakers are each associated with one or more of the plurality of remote sensing devices to determine acoustic properties of an area. Another implementation relates to a method for environmental analysis where non-visual information is detected. The non-visual information is classified and is communicated to a server. | 08-27-2015 |
| 20150242751 | SYSTEM AND METHOD FOR ESTIMATING AUDIENCE INTEREST - Systems, methods and computer-accessible mediums can be provided that can determine an audience interest distribution(s) of content(s) by, for example, receiving first information related to a web behavior(s) of a user(s), determining second information related to a user interest distribution(s) of the user(s) based on the first information, and determining determine the audience interest distribution(s) of the content(s) based on the second information. | 08-27-2015 |
| 20150239935 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS - The present invention relates to peptides having one or more stable, internally-constrained HBS α-helices, where the peptide is capable of interacting with Ras and related proteins. | 08-27-2015 |
| 20150232504 | ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS - The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed. | 08-20-2015 |
| 20150230948 | Y-LOCK TRACHEAL STENT SYSTEM AND METOD OF USE - A Y-Lock tracheal stent system consisting of a stent device, for emplacement in the larynx, and a stent delivery system. A method for employing the stent delivery system to emplace the stent device. | 08-20-2015 |
| 20150218094 | COVALENTLY PATTERNED GRAPHENE SURFACES BY A FORCE ACCELERATED CYCLOADDITION REACTION - The present invention relates generally to molecular printing techniques for use in sensors, arrays, and integrated optics and electronics. The invention features described give rise to the ability to immobilize biological probes by force-induced patterning, while still maintaining the conductivity of the graphene substrate. Most particularly, the present invention relates to covalent patterning of graphene surface using a force-accelerated reaction. | 08-06-2015 |
| 20150206522 | PITCH DETECTION - A string vibration pickup device and methods for using same. The device includes a sensor configured to engage a string to detect vibrations. A pickup base having a pickup in communication with the sensor receives electrical signals indicative of sensed vibrations for the string. | 07-23-2015 |
| 20150206152 | ANTI-COUNTERFEITING TECHNIQUE VIA ATTRIBUTES - Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, for receiving an item identifier that identifies an item and an attribute associated with an item. The received attribute is based upon a hidden attribute that is revealed upon analysis of the item. If the received attribute matches an expected attribute, which is associated with the item identifier, is determined. | 07-23-2015 |
| 20150204888 | QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS - This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid. | 07-23-2015 |
| 20150201889 | SONIFICATION OF IMAGING DATA - Scans of brains result in data that can be challenging to display due to its complexity, multi-dimensionality, and range. Visual representations of such data are limited due to the nature of the display, the number of possible dimensions that can be represented visually, and the capacity of our visual system to perceive and interpret visual data. This paper describes the use of sonification to interpret brain scans and use sound as a complementary tool to view, analyze, and diagnose. The sonification tool may be used as a method to augment visual brain data display. | 07-23-2015 |
| 20150199918 | BLIND AID DEVICE - A blind aid device designed for non-verbal communication between a blind person and a companion includes a body-worn sensor system to be worn by the companion, a body-worn actuation system to be worn by the blind person and a wireless communication link between the body-worn sensor system and the wearable body-worn actuation system. The body-worn sensor system includes a gyroscope configured to detect and record a velocity of tilting and turning head movements of the companion, an accelerometer configured to detect and record an extent of the tilting head movements of the companion, and a magnetic compass sensor configured to detect and record an extent of the turning head movement of the companion. The wearable body-worn actuation system includes an array of control electronics and actuators configured to translate electronic signals transmitted from the body-worn sensor system into physical movements, in real time. | 07-16-2015 |
| 20150193628 | HOMOMORPHICALLY ENCRYPTED ONE INSTRUCTION COMPUTATION SYSTEMS AND METHODS - A homomorphically encrypted one instruction computation (“HEROIC”) computing system is described. The described HEROIC cloud computing system utilizes a homomorphic encryption scheme. The homomorphic encryption scheme allows for meaningful manipulation of encrypted data directly within the encrypted domain (i.e., without the need to first decrypt the data and then re-encrypt the data after processing). The HEROIC cloud computing system eliminates the need for the cloud computing processor to first decrypt data prior to processing thereby eliminating the need for the cryptographic keys to be provided to the provider of the cloud computing system. | 07-09-2015 |
| 20150189959 | SOMATOSENSORY TERMINAL FEEDBACK CANE - A cane that includes a handle and a pylon that includes a satellite leg control operably connected to the handle. The cane further includes a terminal feedback device that is operably connected to the pylon. The terminal feedback device includes a plurality of satellite legs. The terminal feedback device also includes a plurality of wheels on individual axles. Each wheel is operably connected to a single satellite leg. | 07-09-2015 |
| 20150162379 | SCALABLE ORTHOGONAL SPIN TRANSFER MAGNETIC RANDOM ACCESS MEMORY DEVICES WITH REDUCED WRITE ERROR RATES - A magnetic device includes a pinned polarizing magnetic layer having a magnetic vector parallel to a plane of the pinned polarizing magnetic layer. The magnetic device also includes a free layer, separated from the polarizing magnetic layer by a first non-magnetic layer, having a magnetization vector with a changeable magnetization direction. The changeable magnetization vector is configured to change to a first state upon application of a first current of a first polarity and to change to a second state upon application of a second current of a second, opposite polarity. The magnetic device also has a reference layer having a magnetic vector perpendicular to the plane of the reference layer and separated from the free layer by a second non-magnetic layer. | 06-11-2015 |
| 20150148307 | METHODS AND COMPOSITIONS FOR THE PROGNOSIS AND TREATMENT OF RELAPSED LEUKEMIA - The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject. | 05-28-2015 |
| 20150147334 | IMMUNOTHERAPY TARGETING OF THE SHARED ABNORMAL CONFORMATIONAL STATE OF AMYLOIDOGENIC PEPTIDES/PROTEINS - The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease. | 05-28-2015 |
| 20150141480 | CARBOHYDRATE-SELECTIVE RECEPTORS - The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I). | 05-21-2015 |
| 20150134266 | METHOD OF IDENTIFYING THE MOLECULAR BASIS OF THE ACTIVITY OF A DRUG COMPOUND, PHARMACEUTICAL COMPOSITIONS, AND TREATMENT METHODS - The present invention relates to a method of identifying the molecular basis of a drug compound's activity. The invention further relates to a pharmaceutical composition, a kit for treating psychosis in a subject, and a method for treating psychosis and/or schizophrenia. | 05-14-2015 |
| 20150132310 | METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS - The present invention relates to methods of treating and preventing | 05-14-2015 |
| 20150126621 | METHOD FOR PREDICTING RECURRENCE OF MELANOMA USING miRNA ALTERATIONS - Described herein are miRNA-based methods for prognosis of recurrence of melanoma and related methods and kits. The present invention addresses these and other needs by providing a method for predicting the likelihood of recurrence of melanoma (including distal metastasis and locoregional recurrence) in a subject diagnosed with melanoma. In a separate aspect, the invention provides a method for treatment of a melanoma recurrence (including distal metastasis and locoregional recurrence) in a subject in need thereof. | 05-07-2015 |
| 20150125476 | IMMUNOGENIC PEPTIDES AND POLYPEPTIDES FOR PROTECTION AGAINST HIV INFECTION - The present invention relates to an isolated immunogenic peptide chimera comprising a first peptide moiety comprising the amino acid sequence of SEQ ID NO: 1, or at least a contiguous 5 amino acid fragment thereof, a second peptide moiety comprising the amino acid sequence of SEQ ID NO: 2, or at least a contiguous 5 amino acid fragment thereof, and a linker joining the first and second peptide moieties, wherein the first peptide moiety is at the immunogenic peptide chimera's N-terminus and the second peptide moiety is at the immunogenic peptide chimera's C-terminus. Also disclosed is an immunogenic peptide including the amino acid sequence corresponding to SEQ ID NO: 6, or at least a contiguous 5 amino acid fragment thereof, having a length sufficient to form β-hairpin structure. A further aspect of the present invention is an immunogenic peptide including the amino acid sequence corresponding to SEQ ID NO: 15, or at least a contiguous 5 amino acid fragment thereof, capable of folding into an alpha-helical structure. These immunogenic peptides can be inserted into an immunogenic scaffold protein to form an immunogenic polypeptide. The immunogenic peptides or immunogenic polypeptides can be used in an immunogenic vaccine composition and in methods of inducing a neutralizing antibody response, or inducing a protective and non-neutralizing antibody response, or protective antibodies, against HIV-1 gp120 in a subject. Isolated antibodies and methods of detecting are also disclosed. | 05-07-2015 |
| 20150125441 | METHODS OF TREATING DEPRESSION AND PAIN - The present invention provides methods of treating and pharmaceutical compositions useful for treating a mood disorder or depressive symptoms associated with pain, inducing analgesia and treating pain in a subject by administering a pharmaceutically effective amount of an agent capable of one or more of increasing GluA1 level, expression, concentration, or biological activity, increasing calcium permeable AMPA (α amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor (CPAR) level, expression, concentration, or biological activity or potentiating a CPAR current. The agent may be an AMPA potentiator or ampakine. The agent may increase AMPA receptor currents by slowing the deactivation of open channels and may be, for instance, 2-pyrrolidinone, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA) or LY451646. The agent may also be a protein, RNA or DNA product. | 05-07-2015 |
| 20150120209 | METHOD, COMPUTER-ACCESSIBLE MEDIUM, AND SYSTEMS FOR GENERATING A GENOME WIDE HAPLOTYPE SEQUENCE - Methods, computer-accessible medium, and systems for generating a genome wide probe map and/or a genome wide haplotype sequence are provided. In particular, a genome wide probe map can be generated by obtaining a plurality of detectable oligonucleotide probes hybridized to at least one double stranded nucleic acid molecule cleaved with at least one restriction enzyme, and detecting the location of the detectable oligonucleotide probes. For example, genome wide haplotype sequence can be generated by analyzing at least one genome wide restriction map in conjunction with at least one genome wide probe map to determine distances between restriction sites of the genome wide restriction map(s) and locations of detectable oligonucleotide probes of the genome wide probe map(s) and defining a consensus map indicating restriction sites based on the genome wide restriction map(s) and/or locations of detectable oligonucleotide probes based on each of the genome wide probe map(s). | 04-30-2015 |
| 20150119329 | MODULATION OF ANGIOTENSIN II RECEPTORS FOR THE PREVENTION AND TREATMENT OF MALARIA CEREBRAL - The present invention is directed to a composition for the treatment or prevention of cerebral malaria that comprises an angiotensin receptor type-2 agonist and an antimalaria drug. The present invention is further directed to methods for treating and preventing cerebral malaria that involve administering an angiotensin receptor type-2 agonist and/or an angiotensin receptor type-1 antagonist. | 04-30-2015 |
| 20150112066 | ASYMMETRIC CATALYSTS - The present invention relates to asymmetric catalysts, including redox-reconfigurable asymmetric catalysts. Methods of producing compounds having one or more stereocenters using the asymmetric catalysts of the present invention are also disclosed. | 04-23-2015 |
| 20150111764 | POLYMERIZED MICROARRAYS - Micropatterns of glycan-bearing brush polymers generated by the initiation of oligomerization of acrylate and methacrylate monomers from thiol-terminated surfaces. Chain lengths are controlled in situ by varying exposure time, and these multivalent glycan scaffolds detect glycan binding proteins at sub-micromolar concentrations. | 04-23-2015 |
| 20150110822 | ONCOLYTIC HERPES SIMPLEX VIRUS AND THERAPEUTIC USES THEREOF - The present invention relates to variants of herpes simplex virus (HSV) that selectively infect and replicate in cancer cells, including HSV strains that selectively infect and replicate in bladder cancer cells. Preferred HSV of the invention have intact endogenous Us11 and Us12 genes and have genes encoding ICP34.5 replaced with a gene encoding Us11 fused to an HSV immediate early (IE) promoter. The variant HSV of the invention also comprise one or more additional heterologous genes encoding immunomodulatory polypeptides. Methods and compositions using these variant HSV, e.g., for treating cancer in a subject, are also provided. | 04-23-2015 |
| 20150110418 | SEAM CARVING BASED ANONYMIZATION - As image source attribution techniques have become significantly sophisticated and are now becoming commonplace, there is a growing need for capabilities to anonymize images and videos. Focusing on the photo response non-uniformity noise pattern based sensor fingerprinting technique, this work evaluates the effectiveness of well-established seam carving method to defend against sensor fingerprint matching. We consider ways in which seam-carving based anonymization can be countered and propose enhancements over conventional seam carving method. Our results show that applying geometrical distortion in addition to seam carving will make counter attack very ineffective both in terms of computational complexity and accuracy. | 04-23-2015 |
| 20150101663 | ORGANIC PHOTOVOLTAIC DEVICE PRODUCED FROM AN ELECTROCHEMICAL METHOD FOR DEPOSITING NANOFIBRILAR POLY(3,4-ETHYLENEDIOXYTHIOPHENE) (PEDOT) HOLE EXTRACTION LAYER IN ORGANIC SOLAR CELLS - An electrochemical method for producing a hole extraction layer in a solar cell based on organic semiconductor materials. Conjugated polymers are used to build a hole extraction layer and a photoactive layer. Poly(3,4-ethylenedioxythiophene) (PEDOT) is used as a hole extraction layer and is deposited electrochemically from an aqueous solution on an indium tin oxide (ITO) electrode. A nanofibrilar or nanogranular morphology of the PEDOT is achieved by carrying out the polymerization in the presence of a surfactant. A photoactive layer of poly(3-hexylthiophene)/[6,6]-phenyl-C | 04-16-2015 |
| 20150096755 | COMPOSITIONS COMPRISING CARBON DIOXIDE AND REVERSE MICELLES AND METHODS OF USE - Provided herein is a composition comprising carbon dioxide, an aqueous phase, and reverse micelles, wherein the reverse micelles comprise a metal cation-chelating agent, and a metal cation; and methods of using said composition for sequestering carbon dioxide and/or recovering hydrocarbons from a hydrocarbon reservoir. | 04-09-2015 |
| 20150072991 | OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM - The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed. | 03-12-2015 |
| 20150072364 | METHODS AND KITS FOR DIAGNOSING OSTEOARTHRITIS AND PREDICTING PROGRESSION - This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject. | 03-12-2015 |
| 20150067923 | Transgenic Plants And A Transient Transformation System For Genome-Wide Transcription Factor Target Discovery - Plant genes regulated by transcription factors that control the gene network response to an environmental perturbation or signal are described. This class of genes responds to the perturbation of a transcription factor and the signal it transduces, but surprisingly, without stable binding of the transcription factor. These genes represent members of the “dark matter” of metabolic regulatory circuits. | 03-05-2015 |
| 20150067288 | CORRUPTING DATA STRUCTURES FOR PRIVACY PROTECTION - Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, for storing data in both defaultable and non-defaultable memory on a unit in such a way that if a pluggable device is removed from the unit, the defaultable memory is reset to some default state. Further, non-defaultable memory may have data, but that data is unintelligible without data in the defaultable memory. | 03-05-2015 |
| 20150066594 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR DETERMINING ONE OR MORE EFFECTS OF RANKINGS ON CONSUMER BEHAVIOR - Exemplary systems, methods and computer-accessible mediums can be provided which can receive information related to a consumer(s), and determine the search behavior of the consumer(s) based on the information and using a consumer search model that is based on heterogeneous preferences and a search cost model of a second consumer(s). | 03-05-2015 |
| 20150065436 | INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES - The present invention relates to peptidomimetics that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1α-p300/CBP interaction, are also disclosed. | 03-05-2015 |
| 20150062587 | HOLOGRAPHIC MICROREFRACTOMETER - An in-line holographic microscope is used for measurements of micrometer-scale particles and associated suspending fluid medium containing the particles. The system yields heterodyne scattering patterns that may be interpreted with Lorenz-Mie theory to obtain precise time-resolved information on the refractive index of the suspending medium for determining chemical composition, concentrations and makeup thereof. This approach can perform spatially resolved refractometry with measurements on calibrated refractive index standards and monitor chemical concentration in a microfluidic channel. Using commercially available colloidal spheres as probe particles and a standard video camera for detection yields volumetric refractive index measurements with a resolution of 2×10 | 03-05-2015 |
| 20150057759 | MEDIAL TIBIAL PLATEAU REALIGNMENT PROCEDURE FOR MEDIAL OSTEOARTHRITIS OF THE KNEE - A method and apparatus for correcting varus deformity comprises cutting a horizontal slot in the upper medial portion of the tibia. The slot is opened by the application of external force and a wedge is inserted to maintain the opening. The opening of the slot corrects the position and orientation of the deformed medial plateau. | 02-26-2015 |
| 20150055877 | METHOD AND APPARATUS FOR SEGMENTING AN IMAGE IN ORDER TO LOCATE A PART THEREOF - A method is disclosed to automatically segment 3D and higher-dimensional images into two subsets without user intervention, with no topological restriction on the solution, and in such a way that the solution is an optimal in a precisely defined optimization criterion, including an exactly defined degree of smoothness. A minimum-cut algorithm is used on a graph devised so that the optimization criterion translates into the minimization of the graph cut. The minimum cut thus found is interpreted as the segmentation with desired property | 02-26-2015 |
| 20150055845 | System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging - Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates. | 02-26-2015 |
| 20150054635 | HAPTIC FORCE-FEEDBACK FOR COMPUTING INTERFACES - Methods, systems, and apparatuses, including computer programs encoded on computer-readable media, provide two degrees of freedom active force feedback for touchscreens or any other general surface. The system includes a rubber ball attached to a pen-like structure with two motors that are capable of rotating freely when external force is applied. The system has also a mechanical structural arrangement including gears and cables to transfer motor power to engage the rubber ball. The system further includes a digital compass to measure the device tilt, along with a processing unit to control the system and a wireless communication module and a power module. | 02-26-2015 |
| 20150054633 | Interactive Tangible Interface for Hand Motion - Methods, systems, and apparatuses, including computer programs encoded on computer-readable media are disclosed, for receiving, from an inertial measurement unit (IMU) the motion information of an interactive digital stress ball device and from the force detection sensors the pressure information exerted on each of the sensors attached on the ball surface. A haptic actuator and a haptic simulator are used to generate haptic feedback. The sensory analog signals are converted to digital signals and feed into the kinematic computation to calculate performance metrics. Sensory data is transmitted wirelessly to other digital entities. The interactive digital stress ball can also receive digital commands through wireless communication for the generation of the haptic feedback. The electronically embedded stress ball is able to track the motion of the hand and wirelessly transmit a set of kinematics that can be used to control computer games and other peripheral devices. | 02-26-2015 |
| 20150044243 | MUCOSAL IMMUNIZATION TO PREVENT PRION INFECTION - Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration. Suitable adjuvants include cholera toxin subunit B, heat-labile enterotoxin and aluminum hydroxide. Alternatively, the vaccine comprises a vector encoding a prion protein, fragment, or homolog in an attenuated | 02-12-2015 |
| 20150044228 | METHODS TO IDENTIFY COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE AND DIFFERENTIATIVE DISORDERS - The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorder. | 02-12-2015 |
| 20150037285 | METHODS FOR EFFICIENT TRANSFER OF VIABLE AND BIOACTIVE MICROBIOTA - The present invention relates to methods for transferring gastrointestinal microbiota that preserves viability and bioactivity of the microbiota, even if fastidious, anaerobic, and non-culturable organisms are present. Also provided herein are examples of how manipulating the gastrointestinal microbiota and introducing particular taxa can be used to affect host metabolic status related to weight, fat, and obesity. | 02-05-2015 |
| 20150018364 | CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS - The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation). | 01-15-2015 |
| 20150017739 | CONFORMATIONAL-SWITCHING FLUORESCENT PROTEIN PROBE FOR DETECTION OF ALPHA SYNUCLEIN OLIGOMERS - A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers. The use of intrinsically disordered proteins as conformation-switching biosensors. The use of an alpha synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers. | 01-15-2015 |
| 20150017668 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING MOOD DISORDERS - The present invention relates to methods of diagnosing, prognosing or treating diseases or disorders in which elevated or reduced levels of Aβ protein, including Aβ | 01-15-2015 |
| 20150011728 | REVERSIBLY CROSSLINKED HELICAL HYDROGEN BOND SURROGATE MACROCYCLES - The present invention relates to peptides having one or more stable, reversibly and internally-constrained HBS α-helices. | 01-08-2015 |
| 20150011610 | METHOD FOR ENHANCING REMYELINATION USING GLI1 INHIBITORS - The invention provides a method of treatment of multiple sclerosis and other neurological disorders characterized by myelin loss or myelin deficiency by inhibiting Gli1 transcription factor. In a related aspect, the invention provides a method for enhancing neuroprotection of a central nervous system (CNS) or peripheral nervous system (PNS) neuron in a subject in need thereof comprising administering to said subject an effective amount of a Gli1 inhibitor. In one embodiment, the subject has a neurological disorder characterized by myelin loss or myelin deficiency. | 01-08-2015 |
| 20140378531 | INHIBITION OF PATTERN RECOGNITION RECEPTORS IN PANCREATIC CANCER TREATMENT USING TLR INHIBITORS - The disclosure herein relates to the novel finding that pattern recognition receptor activation is central to pancreatic cancer progression, and provides antagonists of pattern recognition receptors (PRRs), including the TLRs 4, 7, and 9, and the CLR dectin-1, for treatment and prevention of pancreatic cancer and pancreatic inflammation. The inventors have discovered that cancer development and progression can be prevented by pattern recognition receptor inhibition, a powerful finding with important clinical and therapeutic implications. | 12-25-2014 |
| 20140378336 | DIAGNOSIS OF CELL PROLIFERATIVE DISEASES - The method of the present disclosure is directed towards a method and a kit for diagnosing a cell proliferative disease. This method includes the following steps; gathering a sample from a subject, measuring the fibulin expression level or measuring the fibulin activity level in the sample, comparing the measured fibulin expression level or measured fibulin activity level to a baseline level of fibulin expression or activity and assigning the subject to a normal or abnormal group based on the measured fibulin expression level or activity level in the sample. The present disclosure is also directed towards a kit for diagnosing a cell proliferative disease. The kit includes a sampler, a measurer, a comparor and an assignor. | 12-25-2014 |
| 20140375353 | SYSTEMS, PROCESSES AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING LOGIC ENCRYPTION UTILIZING FAULT ANALYSIS - Exemplary systems, methods and computer-accessible mediums can encrypting a circuit by determining at least one location to insert at least one gate in the circuit using a fault analysis, and inserting the at least one gate in at least one section of the at least one location. The determination can include an iterative procedure that can be a greedy iterative procedure. The determination can be based on an effect of the particular location on a maximum number of outputs of the circuit. | 12-25-2014 |
| 20140365995 | CONFIGURATION-PRESERVING PREPROCESSOR - Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for generating a plurality of tokens from one or more source files. The one or more source files include source code in a first programming language. The source code includes one or more static conditionals that include a conditional expression and branch code that is operative when the conditional expression is true. Various configurations are possible based upon the conditionals. A first static conditional that includes one or more nested static conditionals within the branch code associated with the first static conditional is determined. Each of the one or more nested static conditionals is hoisted to a beginning of the branch code associated with the first static conditional. Each innermost branch code does not contain a static conditional, and each possible configuration is preserved. | 12-11-2014 |
| 20140350078 | CONTROLLING REGULATORY T CELL FUNCTION - The present invention relates to a method of identifying candidate compounds useful as chemotherapeutics or anti-infective compounds or anti-inflammatory drugs. This method involves providing a plurality of test compounds. The plurality of test compounds are incubated with human Regulatory T (Treg) cells expressing Disc-Large Homo log 1 (Dlgh1) or in which Dlgh1 is suppressed, where the Treg cells have an immunological synapse (IS). Test compounds which inhibit Dlgh1 expression, recruitment to the IS, and/or activity in the Treg cells are identified as candidate compounds potentially useful as chemotherapeutics or anti-infective compounds. Test compounds which enhance Dlgh1 recruitment to the IS and/or activity in the Treg cells are identified as candidate compounds potentially useful as anti-inflammatory drugs. The present invention also relates to methods of treating inflammatory conditions, cancers, and infectious diseases in a subject, as well as methods of inhibiting Treg cell activity. | 11-27-2014 |
| 20140340084 | APPARATUS, SYSTEMS AND METHODS WHICH ARE BASED ON MAGNETIC RESONANCE IMAGING FOR EVALUATION(S) OF RADIO FREQUENCY EMITTING DEVICE(S) - Exemplary system, method and computer accessible medium can be provided for evaluating at least one radio frequency transmitting arrangement. For example, it is possible to receive a first information associated with at least one scan of at least one live subject corresponding to one or more effects of the transmitting arrangement(s) on the at least one live subject, and determine a second information based on the first information. | 11-20-2014 |
| 20140336256 | METHOD OF TREATING TOURETTE'S DISORDER WITH GABA-AMINOTRANSFERASE INACTIVATORS - The present invention is a method of treating Tourette's Disorder (TD) using GABA ergic drugs that elevate the amount of stored presynaptic GABA and do not significantly increase GABA tone (a continuous background level of GABA signaling) in the brain. The administration of vigabatrin and/or (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid hydrochloride salt is expressly contemplated. | 11-13-2014 |
| 20140334518 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING SPECIFIC ABSORPTION RATE OBTAINED BASED ON MAGNETIC RESONANCE IMAGING AND TEMPERATURE PROPERTY MEASUREMENTS - Systems, methods and computer-accessible mediums for determining a specific absorption rate (SAR) of a radio frequency (RF) radiation on an object(s) can be provided, which can, for example hardware arrangement configured to receive thermal information for a portion(s) of the at least one object, and determine the SAR based on the thermal information. | 11-13-2014 |
| 20140330002 | Specificity, Flexibility and Valence of DNA Bonds for Guided Emulsion Architecture - A method of forming an end product by self-assembly of a first component having a patch of a linker component, such as DNA strands, cadherins, adhesive proteins and nanoparticle linkers. Such emulsions can be used to process personal care products, skin cremes, foods and animal feedstocks. | 11-06-2014 |
| 20140314298 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUMS OR DETERMINING NEURODEGENERATION - Method, system and computer-accessible medium for determining at least one of axonal loss or myelin degradation can be provided. For example, it is possible to receive data based on at least one of a measure of diffusion of an axonal structure or a measure of a density of axons, and determine axonal loss and/or myelin degradation based on the data. The determination can be based on axonal geometry of at least one parallel tube. | 10-23-2014 |
| 20140310224 | PREDICTING TEMPERATURE RESPONSE - After the temperature response to a single period of heating (SAR segment) is determined, temperature increases for an arbitrary timecourse of heating is determined based upon a convolution of the temperature response curve for a sequence of different SAR segments. | 10-16-2014 |
| 20140303927 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR DETERMINING TISSUE THERMAL PROPERTY - An exemplary system, method and computer-accessible medium for constructing information regarding a distribution of thermal properties of an objects), can be provided. For example, data related to a temperature of the object(s) can be received at multiple points in time and space at which a portion(s) of the object(s) is heated or cooled. The information can be constructed using the data based on a bio-heat equation. | 10-09-2014 |
| 20140302046 | Immunological Targeting of Pathological Tau Proteins - The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject. | 10-09-2014 |
| 20140298498 | INHIBITION OF ONCOGENIC KRAS-INDUCED GM-CSF PRODUCTION AND FUNCTION - The present invention is directed to methods of inhibiting tumor growth in a subject. The present invention is further directed to methods of diagnosing cancer in a subject and identifying a suitable course of treatment for the subject based on the diagnosis. The present invention is also directed to an orthotopic animal model of pancreatic cancer. | 10-02-2014 |
| 20140288178 | INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION - The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to inhibit c-Myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression. | 09-25-2014 |
| 20140287959 | NANOREACTOR PRINTING - Polymer Pen Lithography is used to induce bioorthogonal reactions between treated surfaces and functionalized inks create a soft matter layer. Fluorescent and redox-active inks were used to demonstrate that the molecules were immobilized covalently and achieves precise control over ligand orientation and density within each feature. Finally, the utility was demonstrated by creating functional arrays of biologically active probes. | 09-25-2014 |
| 20140286955 | NOTCH AGONISTS FOR THE TREATMENT OF CANCER - The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a Notch receptor agonist. | 09-25-2014 |
| 20140283217 | Methods of Affecting Plant Growth With MicroRNA - Provided herein are compositions and methods for producing transgenic plants. In specific embodiments, transgenic plants comprise a construct comprising a polynucleotide encoding microRNA167 (miR167), or precursor thereof, operably linked to a plant pericycle-specific promote, wherein the miR167 is ectopically overexpressed in the transgenic plants, and wherein the promoter is optionally a constitutive or inducible promoter. In some embodiments, the transgenic plant has an improved agronomic or nutritional characteristic when cultivated in nitrogen-rich conditions as compared to a wild type plant cultivated in the same conditions. Also provided herein are commercial products (e.g., pu) | 09-18-2014 |
| 20140273003 | SUPER-RESOLUTION FLUORESCENCE LOCALIZATION MICROSCOPY - The present invention relates generally ultrasensitive assays for use in diagnostics and in methods of drug screening and personalizing therapy for an individual patient. Specifically, the present invention relates to improved imaging and computational methods for detecting molecular phenotypes. | 09-18-2014 |
| 20140256594 | DNA PHOTOLITHOGRAPHY WITH CINNAMATE CROSSLINKERS - The present invention relates generally to cinnamate crosslinkers. Specifically, the present invention relates to gels, biochips, and functionalized surfaces useful as probes, in assays, in gels, and for drug delivery, and methods of making the same using a newly-discovered crosslinking configuration. | 09-11-2014 |
| 20140244035 | Manipulation of Objects - A system for manipulation of objects. The system includes N objects, where N is greater than or equal to 2 and is an integer; and a mechanism for controlling and 2D locating of the N objects. A method for manipulating objects. The method includes the steps of receiving information from N objects, where N is greater than or equal to 2 and is an integer, at a centrally controlling and 2D locating controller; determining 2D locations by the controller of the N objects; and transmitting from the controller directions to the N objects for the N objects to move. An apparatus for tracking. The apparatus includes N objects, where N is greater than or equal to 2 and is an integer, each object having an emitter which emits light; and a mechanism for 2D sensing of the N objects over time from the light emitted by each emitter. The present invention pertains to a method for tracking. The method includes the steps of emitting light from N objects, where N is greater than or equal to 2 and is an integer; and sensing 2D locations of the N objects over time from the emitted light from the N objects. | 08-28-2014 |
| 20140243531 | SUPERSTRUCTURES OF DIKETOPYRROLOPYRROLE DONORS AND PERYLENEDIIMIDE ACCEPTORS FORMED BY HYDROGEN-BONDING AND PI...PI STACKING - A quantitative model that describes the assembly of diketopyrrolopyrrole-based donors and a perylenediimide acceptor into chiral superstructures, as a result of both hydrogen bonding and π•••π stacking. This model provides thermodynamic parameters (ΔH° and ΔS°) for all noncovalent interactions involved in the assembly and explains the subtle supramolecular cues that convert disordered aggregates into well-defined helical assemblies. | 08-28-2014 |
| 20140243260 | CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE - The present invention relates to an isolated chimeric protein. The isolated chimeric protein includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion from a fibroblast growth factor (“FGF”) 23 molecule and the C-terminus includes a C-terminal portion from an FGF19 molecule. The present invention also relates to a pharmaceutical composition including an isolated chimeric protein and a pharmaceutically acceptable carrier. The isolated chimeric protein includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion from a fibroblast growth factor (“FGF”) 23 molecule and the C-terminus includes a C-terminal portion from an FGF19 molecule, and a pharmaceutically-acceptable carrier. Yet another aspect of the present invention relates to a method for treating a subject suffering from a disorder. This method includes selecting a subject suffering from the disorder and administering to the subject a therapeutically effective amount of a chimeric protein according to the present invention. | 08-28-2014 |
| 20140233306 | BIPOLAR SPIN-TRANSFER SWITCHING - A magnetic device includes a magnetized polarizing layer, a free magnetic layer, and a reference layer. The free magnetic layer forms a first electrode and is separated from the magnetized polarizing layer by a first non-magnetic metal layer. The free magnetic layer has a magnetization vector having a first and second stable state. The reference layer forms a second electrode and is separated from the free-magnetic layer by a second non-magnetic layer. Unipolar current is sourced through the polarizing, free magnetic and reference layers. Switching of the magnetization vector of the free magnetic layer from the first stable state to the second state is initiated by application of a first unipolar current pulse, and switching of the magnetization vector of the free magnetic layer from the second stable state to the first stable state is initiated by application of a second unipolar current pulse. | 08-21-2014 |
| 20140221229 | GENOMIC SIGNATURES OF METASTASIS IN PROSTATE CANCER - A method of determining the risk of metastasis of prostate cancer in a human subject who has or had prostate cancer is disclosed herein. The method is based on detecting in a prostate sample from the subject the number of copies per cell of genes and/or genomic regions of a metastatic gene signature set disclosed herein, and determining alternations in the number of copies per cell of the genes and/or genomic regions in the signature set, as compared to the number of copies per cell in non-cancer cells, thereby determining the risk of prostate cancer metastasis. | 08-07-2014 |
| 20140212456 | TREATMENT METHODS USING ATOXIC NEUROTOXIN DERIVATIVES - The present invention relates to a treatment method. This method involves contacting a subject with an isolated, physiologically active, atoxic derivative of a Clostridial neurotoxin. Contacting is carried out to treat the subject. The derivative of a Clostridial neurotoxin does not possess a cargo attachment peptide sequence at its N-terminus. | 07-31-2014 |
| 20140212413 | Methods of Treating TNF-alpha-Mediated Diseases Using Chimeric TNF-alpha Antibodies - Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided. | 07-31-2014 |
| 20140205153 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUMS FOR AUTHENTICATION AND VERIFICATION OF PHYSICAL OBJECTS - Exemplary methodology, procedure, system, method and computer-accessible medium can be provided for authenticating a non-digital medium of a physical object, by receiving at least one image of video of at least one marked or unmarked region, and comparing the first microscopic image or video of at least one marked or unmarked region with at least one second microscopic image or video relating to the non-digital medium to determine if a similarity between the first and second microscopic images or videos matches or exceeds a predetermined amount. | 07-24-2014 |
| 20140191439 | Continuous Feed 3D Manufacturing - Disclosed herein is a method and apparatus adapted for the free-form manufacture of complex systems using multiple three-dimensional (3D) printing techniques using multiple materials on a continuously rotating disk with a flat surface in combination with the continuous increasing of distance between the material(s) source(s) and the build surface so as to allow for the continuous feed manufacturing of 3D Objects and complex systems. The continuous rotation of the build platform in combination with the continuous z-axis motion of the build platform results in the deposit of a continuously forming helically shaped layer that folds back onto previously deposited sections of the helix and thereby forms a 3D object or system of objects. | 07-10-2014 |
| 20140170647 | Compositions and Methods for Analyzing Immobilized Nucleic Acids - The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte. | 06-19-2014 |
| 20140155316 | FIBROBLAST GROWTH FACTOR 1 PROTEIN FRAGMENTS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF19 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 06-05-2014 |
| 20140142120 | METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2 - The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity. | 05-22-2014 |
| 20140141167 | POLYMER TIPS - Polymer Pen Lithography materials that retain the simplicity characteristic for the fabrication of poly(dimethyl siloxane) tip arrays while preserving the control over feature dimensions and to understand the role of the mechanical properties of the different materials on Polymer Pen Lithography printing. | 05-22-2014 |
| 20140135743 | System and Method for Correction of Intracerebral Chemical Imbalances - A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit. A system for treating disorders of the central nervous system (CNS), comprises first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient's CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS and a first reservoir imlpantable within the patient's body and holding material to be introduced to the CNS in combination with a first pump coupled to the first reservoir and the first conduit for introducing the material to the CNS via the first conduit and a brain wave detection unit for detecting and analyzing brain waves of the patient. | 05-15-2014 |
| 20140107979 | PRECISE FERQUENCY-PATTERN ANALYSIS TO DECOMPOSE COMPLEX SYSTEMS INTO FUNCTIONALLY INVARIANT ENTITIES - Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for registering a multichannel time series from data collected from a plurality of channels. Each channel corresponds to one of one or more sensors. A precise Fourier transform of the data from all channels is done to transform the data in a frequency domain. Frequencies from the frequency domain are selected. The selected frequencies from all channels are inverse Fourier transformed. A restored time is selected, and activity for the selected frequencies at the restored time is localized. Coherence for the selected frequencies is estimated and coherent components are extracted. Partial spectrum is assembled comprising frequencies with similar patterns of the coherent components. Inverse transform of the partial spectrum is used to reconstruct a time series for functional entities producing the similar patterns of the coherent components. | 04-17-2014 |
| 20140107022 | CHIMERIC FIBROBLAST GROWTH FACTOR 19 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF19 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 04-17-2014 |
| 20140103473 | INCREASED MAGNETORESISTANCE IN AN INVERTED ORTHOGONAL SPIN TRANSFER LAYER STACK - A magnetic device includes a pinned magnetic layer and a free magnetic layer including a first body-centered cubic material and having a variable magnetization vector that has a first stable state and a second stable state. The magnetic device also includes a first non-magnetic layer and a reference layer. The first non-magnetic layer spatially separates the pinned magnetic layer and the free magnetic layer and includes a second body-centered cubic material that interfaces with the first body-centered cubic material. The magnetic device includes a second non-magnetic layer spatially separating the free magnetic layer and the reference magnetic layer. A magnetic tunnel junction, located below the pinned magnetic layer, is formed by the free magnetic layer, the second non-magnetic layer, and the reference magnetic layer. Application of a current pulse through the magnetic device switches the variable magnetization vector. | 04-17-2014 |
| 20140103472 | INVERTED ORTHOGONAL SPIN TRANSFER LAYER STACK - A magnetic device includes a pinned magnetic layer having a first fixed magnetization vector with a first fixed magnetization direction. The magnetic device also includes a free magnetic layer having a variable magnetization vector having at least a first stable state and a second stable state. The magnetic device also has a first non-magnetic layer and a reference. The first non-magnetic layer spatially separates the pinned magnetic layer and the free magnetic layer. The magnetic device also includes a second non-magnetic layer spatially separating the free magnetic layer and the reference magnetic layer. A magnetic tunnel junction, located below the pinned magnetic layer, is formed by the free magnetic layer, the second non-magnetic layer, and the reference magnetic layer. Application of a current pulse, having either positive or negative polarity and a selected amplitude and duration, through the magnetic device switches the variable magnetization vector. | 04-17-2014 |
| 20140100354 | PEPTOID COMPOSITIONS AND METHODS OF USING THE SAME - Novel peptoids are disclosed that have a formula represented by the following formulae Ia and Ib: | 04-10-2014 |
| 20140094457 | PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF GENETIC DISEASES ASSOCIATED WITH NONSENSE MEDIATED RNA DECAY - The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject. | 04-03-2014 |
| 20140094406 | CHIMERIC FIBROBLAST GROWTH FACTOR 21 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF21 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 04-03-2014 |
| 20140089144 | APPARATUS, SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PERFORMING A PRODUCT SEARCH USING USER-GENERATED AND CROWD-SOURCED CONTENT - A non-transitory computer-readable medium, method and system for providing results associated with a ranking of a plurality of items of a particular item type can be provided. For example, for each respective item of a plurality of items having an associated cost, it is possible to (i) determining an item utility value for the respective item of the items based on aggregate data associated with a plurality of users without requiring utilization of information particular to each of the users, and (ii) determine a surplus value for the respective item as the item utility value less a cost utility value associated with the cost of the respective item. Further, it is possible to provide the results, based on the respective surplus values, to a particular user of the users. | 03-27-2014 |
| 20140086826 | SIN3B COMPLEX INHIBITION FOR PREVENTING HEMATOLOGIC CHEMOTHERAPY- AND RADIOTHERAPY-INDUCED CYTOTOXICITY - Methods for inactivating Sin3B and its associated activities to prevent, inhibit or attenuate hematopoietic stem cell exhaustion and chemotherapy- and radiotherapy-induced hematologic cytotoxicity are provided. | 03-27-2014 |
| 20140080899 | miR-33 Inhibitors and Uses Thereof to Decrease Inflammation - The inhibition of miRNA miR-33 is shown to promote the polarization of macrophages from an M1 to an M2 phenotype. MiR-33 inhibitors are therefore useful for treating inflammation in subjects. Endogenous microRNAs can be silenced using antagomirs. The miR-33 inhibitor is preferably an antagomir having a single-stranded nucleic acid sequence that is complementary to at least 12 contiguous nucleotides in miR-33 and therefore forms a duplex with miR-33 under physiological conditions. | 03-20-2014 |
| 20140080824 | STRUCTURE-GUIDED IDENTIFICATION OF BINDING INTERACTIONS OF HUMAN LAMININ RECEPTOR PRECURSOR WITH LAMININ AND IDENTIFICATION OF COMPOUNDS THAT AFFECT BINDING - The present invention pertains to compounds which interfere with the binding of laminin to the laminin receptor (LamR). Such compounds are useful for treating diseases such as cancer, Alzheimer's Disease, and certain viral and bacterial infections. | 03-20-2014 |
| 20140067079 | IMPLANTS FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE - A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end conforming to the shape of the tibia, and is made of a metal alloy or a ceramic. The upper surface is dished while the lower surface is planar and can be parallel or sloped relative to the upper surface. The femoral implant for implementation in a femoral condyle is rounded such that, when implemented, the femoral implant is flush at the anterior and posterior sides and protruding away from the femur between the anterior and posterior ends. The femoral implant can have an elongated keel for extending into the femur, and can be made from a highly cross-linked polyethylene. | 03-06-2014 |
| 20140066951 | COCHLEAR IMPLANT WITH IMPROVED ELECTRODE ARRAY AND CONTROLLER - A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi joint robot so as to adjust the position of the actuator units. | 03-06-2014 |
| 20140066362 | METHOD FOR TREATING INFECTIONS BY TARGETING MICROBIAL H2S-PRODUCING ENZYMES - The invention provides materials and methods for treating infections by reducing endogenous microbial H | 03-06-2014 |
| 20140057961 | SIN3B COMPLEX INHIBITION AND USE THEREOF IN THE PREVENTION OF PRO-ONCOGENIC INFLAMMATION AND CANCER - Methods for inactivating Sin3B and its associated activities to prevent, inhibit or attenuate pro-oncogenic inflammation and cancer progression, in particular pancreatic cancer progression are provided. | 02-27-2014 |
| 20140057905 | CANCER DIAGNOSTICS, THERAPEUTICS, AND DRUG DISCOVERY ASSOCIATED WITH MACROPINOCYTOSIS - The present invention is directed to methods of inhibiting both proliferation and survival of cancer cells and for treating a subject having cancer. The present invention is further directed to methods of diagnosing cancer in a subject and identifying cancer therapeutics. | 02-27-2014 |
| 20140052686 | METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR RECONSTRUCTING FORMAL DESCRIPTIVE MODELS OF PROCESSES FROM FUNCTIONAL/MODAL DATA USING SUITABLE ONTOLOGY - A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc. | 02-20-2014 |
| 20140050803 | COMPOSITIONS AND METHODS FOR TREATMENT OF MELANOMA - Described herein are compositions and methods for the prognosis, prevention and treatment of melanoma or melanoma associated symptoms. The compositions are microRNA molecules associated with melanoma or with melanoma brain tropism, as well as various nucleic acid molecules relating thereto or derived therefrom. | 02-20-2014 |
| 20140046452 | TOTAL KNEE REPLACEMENT SUBSTITUTING FUNCTION OF ANTERIOR CRUCIATE LIGAMENT - A total knee replacement prosthesis comprising condylar and intercondylar bearing surfaces configured to manage anterior/posterior displacement between the articulating femoral and tibial components. | 02-13-2014 |
| 20140045860 | SMALL MOLECULE INHIBITORS FOR TREATING PARASITIC INFECTIONS - The invention relates to a compound of Formula I or a pharmaceutically acceptable ester, salt, prodrug or metabolite thereof; | 02-13-2014 |
| 20140045769 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS - The present invention relates to peptides having one or more stable, internally-constrained HBS α-helices, where the peptide is capable of interacting with Ras and related proteins. | 02-13-2014 |
| 20140045756 | METHODS AND COMPOSITIONS FOR MODULATING TNF/TNFR SIGNALING - The present disclosure relates to methods and compositions for modulating TNF and TNFR signaling. In particular, the disclosure describes methods and compositions for inhibiting TNFα signaling, such as in the prevention or treatment of TNFα-related diseases. | 02-13-2014 |
| 20140037629 | HUMANIZED SINGLE-CHAIN ANTIBODY AGAINST BETA 3 INTEGRIN FOR THE TREATMENT AND PREVENTION OF METASTASIS - The present invention relates to methods inhibiting tumor metastasis and treating cancer in a subject that involve administering to the subject an antibody which recognizes GPIIIa49-66, under conditions effective to inhibit tumor metastasis and/or treat cancer in the subject. | 02-06-2014 |
| 20140025716 | COMPUTATIONS USING A POLYCHRONOUS WAVE PROPAGATION SYSTEM - The present invention relates to a polychronous wave propagation system that is based on relative timing between two or more propagated waves through a wave propagation medium. The relative timing may be associated with interference patterns of energy between the propagated waves. Operational behavior of the polychronous wave propagation system is based on the relative timing of the propagated waves and distances between initiators that transmit the propagated waves and responders that receive the propagated waves. The operational behavior may include arithmetical computations, memory storage, Boolean functions, frequency-based computations, or the like. The polychronous wave propagation system relies on time delays between the propagated waves that result from propagation velocities of the propagated waves through the wave propagation medium. By incorporating the time delays into the system, operational capacity may be greatly enhanced. | 01-23-2014 |
| 20140018936 | INCREASING SURVIVAL OF FREE TISSUE GRAFTS AND FLAPS USING PHOSPHODIESTERASE TYPE 5 (PDE5) INHIBITORS - The present invention relates to methods of tissue grafting and microvascular free flap transfer that involve administering a phosphodiesterase type-5 inhibitor to the tissue graft or microvascular free flap to produce a treated graft or flap, and implanting the treated graft or flap into a recipient site of a host subject. | 01-16-2014 |
| 20130338225 | Compounds As L-Cystine Crystallization Inhibitors And Uses Thereof - A method of preventing or inhibiting L-cystine crystallization using the compounds of formula I is disclosed. | 12-19-2013 |
| 20130336988 | METHODS FOR TREATING EARLY STAGE OR MILD NEUROLOGICAL DISORDERS - This disclosure relates to modulation of the interactions between proNTs and p75 | 12-19-2013 |
| 20130331325 | CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the αKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 12-12-2013 |
| 20130331317 | CHIMERIC FIBROBLAST GROWTH FACTOR 19 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF19 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 12-12-2013 |
| 20130331316 | CHIMERIC FIBROBLAST GROWTH FACTOR 21 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF21 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 12-12-2013 |
| 20130326204 | Configuration-Preserving Preprocessor and Configuration-Preserving Parser - Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for generating a plurality of tokens from one or more source files that include source code in a first programming language. The source code includes one or more static conditionals that include a conditional expression and branch code that is operative when the conditional expression is true. Various configurations are possible based upon the conditionals. A first static conditional includes one or more nested static conditionals within the branch code associated with the first static conditional. Each of the one or more nested static conditionals is hoisted to a beginning of the branch code associated with the first static conditional. Each innermost branch code does not contain a static conditional and each possible configuration is preserved. | 12-05-2013 |
| 20130318414 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DESIGN FOR TESTABILITY SUPPORT FOR LAUNCH AND CAPTURE OF POWER REDUCTION IN LAUNCH-OFF-CAPTURE TESTING - Exemplary system, method and computer accessible medium that can transform a circuit by selecting at least one scan cell as an interface register and inserting a shadow register into each interface register. Operations can be shifted to load and unload at least one scan cell in the circuit. An operation can be launched in at least one of the interface registers and in a first set of scan cells. A capture operation can be performed in a second set of scan cells. An operation can be restored in at least one interface register by transferring data from at least one shadow register. | 11-28-2013 |
| 20130317755 | Methods, computer-accessible medium, and systems for score-driven whole-genome shotgun sequence assembly - Exemplary systems, methods and computer-accessible mediums for assembling at least one haplotype or genotype sequence of at least one genome can be provided, which can include, obtaining a plurality of randomly located sequence reads, incrementally generating overlap relations between the randomly located sequence reads using a plurality of overlapper procedures, and generating a layout of some of the randomly located short sequence reads based on a function in combination with constraints based on information associated with the one genome while substantially satisfying the constraints. The score-function can be derived from overlap relations between the randomly located short sequence reads. A search can be performed together with score- and constraint-dependent pruning to determine the layout substantially satisfying the constraints. A part of the genome wide haplotype sequence or the genotype sequence of the genome can be generated based on the overlap relations and the randomly located sequence reads. | 11-28-2013 |
| 20130314088 | MULTI-CHANNEL COIL ARRANGEMENT - A multi-frequency coil array arrangement can be provided. For example, a plurality of radio frequency coil arrangements can have a first coil arrangement(s) resonant at a single first frequency and a second coil arrangement(s) resonant at a single second frequency which is lower than the first frequency | 11-28-2013 |
| 20130310682 | CSF Biomarker Dilution Factor Corrections by MRI Imaging and Algorithm - A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease. | 11-21-2013 |
| 20130309253 | CANCER TREATMENT WITH ENDOTHELIN RECEPTOR ANTAGONISTS - The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically the present invention relates to a novel method of treating cancer using antagonists to the endothelin B receptor (ETB) or inactive mimic forms of endothelin-1. The pharmaceutical compositions of the invention are capable of selectively inhibiting the early events associated with the development of cancer. The present invention further relates to screening assays to identify compounds which inhibit ETB activation. | 11-21-2013 |
