| NATIONAL RESEARCH COUNCIL OF CANADA Patent applications |
| Patent application number | Title | Published |
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| 20220299544 | ATOMIC NANO-POSITIONING DEVICE - A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging. | 09-22-2022 |
| 20220274112 | Oil Residue Protection in Oil-Encapsulated Digital Microfluidics - A technique for supplying droplet content of an oil-encapsulated (OE) digital microfluidic (DμF) network to a region that is sensitive to oil contact involves sealing off a boundary surrounding the sensitive region with a volume of liquid that is miscible with payload of the OE-droplets. The sensitive region may be an opening to a microfluidic channel, or a sensor surface. The sealing off may be provided by transporting an unencapsulated droplet over the OE-DμF chip, either from a reservoir prior to oil encapsulation of the reservoir, or from a non-oil encapsulated reservoir; or by injecting the liquid into the microfluidic channel. A suitable treatment of the boundary may anchor the liquid to the boundary, and prevent removal by ordinary OE-DμF operations. A remainder of the surfaces of unit cells the DμF chip may provide higher droplet contact angle. | 09-01-2022 |
| 20220241786 | Centrifugal Microfluidic Chip, Kit and System for On-Chip Gas Supply - A centrifugal microfluidic chip is provided that allows an on-chip chamber to provide humidification control, or more generally, gas composition control, to another chamber of the chip. This allows for microfluidic incubation using low-cost and efficient centrifugal devices such as multi-port pneumatic chip controllers, single or multi-port pneumatic slip rings, and articulated centrifugal blades with a pneumatic slip ring. The device may be used for cell culturing, microorganism testing, or production of chemical species from biological samples with a controlled microenvironment. | 08-04-2022 |
| 20220102197 | TREATING A SILICON ON INSULATOR WAFER IN PREPARATION FOR MANUFACTURING AN ATOMISTIC ELECTRONIC DEVICE INTERFACED WITH A CMOS ELECTRONIC DEVICE - A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed. | 03-31-2022 |
| 20220072816 | Articulated Forming Caul for Composite Blank Vacuum Forming - A vacuum bag system (VBS) for forming pre-consolidated composite blanks has a blank enclosure for sealing around a periphery of the blank, while leaving a second side of the blank exposed, an articulated forming caul (AFC) with at least two facets, each facet effectively jointedly coupled to an adjacent facet, and having a respective, independently controlled, heater integrated with, or coupled to the facet. The VBS further has a forming enclosure for sealing around a periphery of a tool. The blank enclosure brings the blank and the facets into uniform thermal contact resistance and mechanical contact; and permits the articulated AFC to distribute thermal and mechanical load across the blank during forming, even as the facets move to align to faces of the mold. | 03-10-2022 |
| 20220008924 | WORLD-TO-CHIP AUTOMATED INTERFACE FOR CENTRIFUGAL MICROFLUIDIC PLATFORMS - A centrifugal microfluidic platform is combined with a stationary liquid pumping system which pumps liquids into microfluidic chips by dripping through a stationary dispensing nozzle without any physical contact or coupling between the nozzles and the microfluidic chips. | 01-13-2022 |
| 20210396895 | Printed Film Electrostatic Concentration For Radon Detection - An electrostatic concentrator for use in radon detection, comprising of a plastic sheet having conductive electrodes patterned onto the surface. The sheet is patterned and cut in such a way that it can be assembled into a three-dimensional shape (e.g. a cone), such that when a voltage is applied to the electrodes an electrostatic field is created for propelling radon progeny towards a sensor on which it can be detected. | 12-23-2021 |
| 20210332096 | ENGINEERED TGF-BETA MONOMERS AND THEIR USE FOR INHIBITING TGF-BETA SIGNALING - Recombinant transforming growth factor (TGF)-β monomers modified to inhibit dimerization and block TGF-β signaling are described. The recombinant TGF-β monomers lack the ability to bind and recruit TGF-β type I receptor (TβRI), but retain the capacity to bind the high affinity TGF-β type II receptor (TβRII), and in some instances, include mutations that increase their affinity for TβRII. Nucleic acid molecules and vectors encoding the recombinant TGF-β monomers are also described. Isolated cells, such as T cells, can be re-programmed with a TGF-β monomer-encoding nucleic acid or vector to secrete the monomer. Use of the recombinant TGF-β monomers and/or cells producing the recombinant TGF-β monomers, to inhibit TGF-β signaling, such as to treat disorders associated with aberrant TGF-β signaling, are also described. | 10-28-2021 |
| 20210325429 | INITIATING AND MONITORING THE EVOLUTION OF SINGLE ELECTRONS WITHIN ATOM-DEFINED STRUCTURES - A method for the patterning and control of single electrons on a surface is provided that includes implementing scanning tunneling microscopy hydrogen lithography with a scanning probe microscope to form charge structures with one or more confined charges; performing a series of field-free atomic force microscopy measurements on the charge structures with different tip heights, where interaction between the tip and the confined charge are elucidated; and adjusting tip heights to controllably position charges within the structures to write a given charge state. The present disclose also provides a Gibb's distribution machine formed with the method for the patterning and control of single electrons on a surface. A multi bit true random number generator and neural network learning hardware formed with the above described method are also provided. | 10-21-2021 |
| 20210013424 | 3,7-BIS(2-OXOINDOLIN-3-YLIDENE)BENZO[1,2-B:4,5-B']DIFURAN-2,6-DIONE DICYANIDE-BASED MATERIALS AND USES THEREOF IN ORGANIC ELECTRONIC DEVICES - The development of air-stable unipolar n-type semiconductors with good solubility in organic solvents at room temperature remains a critical issue in the field of organic electronics. Moreover, most of the existing semiconducting materials exhibit LUMO energy levels higher than −4.0 eV, making electron transport sensitive to both moisture and oxygen. Bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are disclosed herein. More specifically, bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof for use in organic electronics are disclosed. A process for the preparation of bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide and derivatives is also disclosed. The bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are characterized by high electron mobilities and are suitable for use as n-type semiconductors in organic electronics. | 01-14-2021 |
| 20200411855 | NICKEL HYDROXIDE, POSITIVE ELECTRODE MATERIAL, ALKALINE BATTERY, AND METHOD OF PRODUCING NICKEL HYDROXIDE - A nickel hydroxide includes stacked nickel hydroxide layers. Each of the nickel hydroxide layers includes Ni | 12-31-2020 |
| 20200408332 | POLYMERIC MICROFLUIDIC VALVE - In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area. | 12-31-2020 |
| 20200407565 | BORON NITRIDE NANOTUBE COATED SUBSTRATES FOR SINTERING OF METALLIC TRACES BY INTENSE PULSE LIGHT - A composite includes a plastic substrate and an electrical insulator layer formed on the plastic substrate. The electrical insulator layer contains boron nitride nanotubes (BNNTs), which may be unmodified or modified BNNTS. The composite is suitable for use in making printed electronic devices. A process includes providing a plastic substrate and forming on at least a portion of a surface of the plastic substrate a layer that contains the BNNTs. A metallic ink trace is formed on a portion of the layer, such that the metallic ink trace is spaced-apart from the substrate. Using photonic or thermal sintering techniques, the metallic ink trace is then sintered. | 12-31-2020 |
| 20200262703 | MODIFIED BORON NITRIDE NANOTUBES AND SOLUTIONS THEREOF - A modified boron nitride nanotube (BNNT) comprising pendant hydroxyl (OH) and amino (NH | 08-20-2020 |
| 20190001360 | APPARATUS AND METHOD FOR AEROSOL DEPOSITION OF NANOPARTICLES ON A SUBSTRATE - Provided is an apparatus for aerosol deposition of nanoparticles on a substrate. The apparatus includes: an aerosol generator for generating an aerosol of micron-sized droplets, each droplet having a limited number of nanoparticles; and a deposition chamber for receiving the aerosol from the aerosol generator. The deposition chamber having an electrostatic field for attracting droplets in the aerosol to the substrate. The electrostatic field being substantially perpendicular to the substrate. The apparatus allows for films/networks of nanoparticles to be patterned on the substrate to sub-millimeter feature sizes, which allows the fabrication of transistor devices for printable electronics applications. Also provided are methods for depositing nanoparticles on a substrate and materials having networks of such nanoparticles. | 01-03-2019 |
| 20180156306 | COMPACT VIBRATION REDUCING HUMAN SUPPORT - A vibration reduction (VR) human support has exactly two paths to ground in each degree of VR: one provided by respective displacement actuators (DAs) for active VR, the other by one or more elastomeric damping bodies (EDBs). These paths extend from a frame for carrying a support structure for a live human, to a grounding for fixing the VR system in a vibrating environment. Each EDB is composed of a material having a dynamic Young's Modulus of 0.1-2.5 MPa, and a resilience test rebound height less than 40, and is positioned between the grounding and frame to provide elastic restorative forces and damping in each of the respective directions. The use of EDBs simplifies construction, and allows for a more compact arrangement, without reducing VR efficiency. | 06-07-2018 |
| 20170174746 | Recombinant Bacterium and Uses Thereof - The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type Ill secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided. | 06-22-2017 |
| 20170173589 | Swivel Mount for Centrifugal Microfluidic Chip - A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part ( | 06-22-2017 |
| 20170167982 | METHOD AND APPARATUS FOR FAST QUANTITATIVE ANALYSIS OF A MATERIAL BY LASER INDUCED BREAKDOWN SPECTROSCOPY (LIBS) - The invention discloses an apparatus and method for use with Laser Induced Breakdown Spectroscopy (LIBS) systems that can be applied to the real time analysis of various materials. The invention, in one aspect, provides a layer-by-layer method to remove the undesired coating layer of a material in which a pulsed laser is coupled with high speed scanning optics. To prepare the surface for LIBS, (i) a pulsed laser beam is scanned over an area of the surface to ablate the surface coating layer; (ii) the laser parameters are changed (i.e. pulse duration is made smaller) and the area scanned again to polish the surface; and (iii) the laser parameters are changed again (i.e. pulse duration is made smaller yet again) and the area scanned again with spectrometric analysis of the plasma plume created by the laser (i.e. LIBS is performed). | 06-15-2017 |
| 20170045404 | AIR SENSOR WITH DOWNSTREAM FACING INGRESS TO PREVENT CONDENSATION | 02-16-2017 |
| 20170044289 | RADIATION CURABLE POLYMER FORMULATION AND METHODS FOR THE PREPARATION THEREOF | 02-16-2017 |
| 20170044238 | ENGINEERING OF IMMUNOGLOBULIN DOMAINS | 02-16-2017 |
| 20170022277 | INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR -SPECIFIC ANTIBODIES AND USES THEREOF - The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated. | 01-26-2017 |
| 20160380259 | METALLIC SURFACE WITH KARSTIFIED RELIEF, FORMING SAME, AND HIGH SURFACE AREA METALLIC ELECTROCHEMICAL INTERFACE - A metal electrode, current collector, or electrochemical interface is karstified vacuum laser ablation to increase surface area and reduce oxides. The electrode may be coated with a conductive non-oxidizing layer. The current collector may be a foil less than 1 mm, or 0.5 mm thick. The karstified topography is marked by: a microstructure with a maximum peak height minus a maximum profile depth greater than 0.5 μm; a surface roughness, of at least 0.2 μm, and an oxygen at. % of 5 or less, is shown to have advantageous use as a high surface area metallic electrochemical interface. The foil may be composed of Al, Ti, Ni, Cu, stainless steel or an alloy or mixture of one or more of the above, and may have a coating consisting of Ni, Ti, C, any alloy of the above, nickel oxide, titanium dioxide, zinc oxide, indium tin oxide, or a mixture of carbon and any one or more of the above. Karstifying the metal foil, involves retaining the foil within a vacuum chamber; evacuating the chamber to a pressure less than 7×10 | 12-29-2016 |
| 20160161111 | FLOW CONTROL OF COMBUSTIBLE MIXTURE INTO COMBUSTION CHAMBER - In a premix supply, for supplying a fuel and oxidizer gas into a combustion chamber for burning, the premix supply having a smaller diameter flow than the combustion chamber, the premix supply comprising at least one dielectric barrier discharge device (DBD) comprising two electrodes separated by a dielectric, improved flame stability limits may be provided for the adjacent combustor by the actuation of the DBD to induce ionic wind. Both electrodes may be provided in a single wall of the premix supply. The two electrodes may be arranged substantially upstream and downstream of each other. The electrodes may be arranged to generate an ionic wind preferentially directed in a direction of flow through the premix supply. | 06-09-2016 |
| 20160138168 | METHOD FOR APPLYING A COATING TO A SUBSTRATE - A method for applying a coating to a substrate surface is provided. The method involves cold spraying a coating material against the surface of the substrate at a first velocity. The first velocity is lower in magnitude than a critical velocity. The method also involves cold spraying the coating material against the surface of the substrate at a second velocity. The second velocity is greater in magnitude than the critical velocity. The critical velocity is a threshold velocity below which the coating material is substantially deflected by the surface of the substrate and above which the coating material substantially adheres to the surface of the substrate. | 05-19-2016 |
| 20160052995 | METHOD FOR ISOLATION OF SOLUBLE POLYPEPTIDES - Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human V | 02-25-2016 |
| 20160024633 | Cold Gas Dynamic Spray Apparatus, System and Method - A system for cold gas dynamic spraying of particulate material has a de Laval nozzle and two or more radial particle inlets located between the throat and the outlet of the nozzle, the two or more particle inlets arranged symmetrically around a linear flow path of the nozzle. Blocking of the inlets is reduced by controlling pressure of particle carrier gas to provide a stable particulate material injection pressure before and during introduction of working gas into the nozzle, and/or by clearing the particle inlets of residual particles after a spraying process. Such a system and associated method combines benefits of both downstream and upstream cold gas spray systems. Further, a nozzle for spraying particulate material having a cross-sectional shape that is narrower in a middle section compared to edge sections provides coatings with superior cross-sectional profiles. | 01-28-2016 |
| 20150376745 | METAL MATRIX COMPOSITE AND METHOD OF FORMING - Use of Ca in metal matrix composites (MMC) allows for incorporation of small and large amounts of ceramic (e.g. rutile Ti0 | 12-31-2015 |
| 20150307597 | ANTI-CAMPYLOBACTER JEJUNI ANTIBODIES AND USES THEREFOR - is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific to | 10-29-2015 |
| 20150232502 | Novel Neisseria gonorrhoeae therapeutic based on CMP-nonulosonate sugars - has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the | 08-20-2015 |
| 20150214496 | CNT Thin Film Transistor With High K Polymeric Dielectric - A thin film transistor (TFT) has a gate electrode; a gate insulation layer, a semiconducting channel separated from the gate electrode by the gate insulation layer; a source electrode and a drain electrode. The gate insulation layer is a cross-linked cyanoethylated polyhydroxy polymer, e.g. a cross-linked cyanoethylated pullulan, having a high dielectric constant and the semiconducting channel has a network of semiconducting carbon nanotubes. The semiconducting channel is adhered to the gate insulation layer through a polymeric material. The carbon nanotubes adhere to the polymeric material and the polymeric material reacts or interacts with the gate insulation layer. TFTs have high mobilities while maintaining good on/off ratios. | 07-30-2015 |
| 20150157376 | METHOD OF PRODUCING A POROUS BONE SCREW - A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula. | 06-11-2015 |
| 20150154007 | RANDOM NUMBER GENERATOR - A method of generating a random number that involves applying pulses of energy to amplify a quantum mechanical vacuum fluctuation to generate one or more macroscopic fields having one or more physical properties (e.g. phase or energy) that are random and measureable, and, measuring at least one of the physical properties to obtain a value for the physical property, the value of the physical property being a random number. Measuring the phase of a Stokes signal generated in a transient Raman scattering process is one way of generating the random number as the phase of the Stokes signal is random. This method can produce random numbers faster than prior art methods as the real numbers generated can be converted to binary to produce more than one random bit and the measurement process itself is faster permitting more rapid data collection rates and more rapid turn-on times. | 06-04-2015 |
| 20150129283 | PROPERTIES OF PRINTED CONDUCTIVE TRACKS - A process for improving a property of a conductive ink track on a substrate involves applying heat and pressure above a glass transition temperature of the binder to a conductive ink track deposited on a first surface of a substrate, while maintaining a second surface of the substrate at a temperature below a glass transition temperature, a melting temperature or a degradation temperature of the substrate. In particular, electrical conductivity of the track is improved. The process is particularly useful for producing electronic devices, for example electrical circuits, sensors, antennae (e.g. RFID antennae), touch switches and smart drug packaging on various substrates | 05-14-2015 |
| 20150093412 | USE OF SACCHARIDES CROSS-REACTIVE WITH BACILLUS ANTHRACIS SPORE GLYCOPROTEIN AS A VACCINE AGAINST ANTHRAX - Provided are immunogenic compositions and methods for eliciting an immune response against | 04-02-2015 |
| 20150077107 | Method for B0 Field Correction in Magnetic Resonance - In a magnetic resonance (MR) experiment, a method for effectively improving B0 uniformity of a static magnet of a magnetic resonance (MR) apparatus, without shimming magnets or coils involves combining a plurality of RF receive fields, each having a different respective sensitivity map. This method can apply retrospectively to previously acquired data, as long as there is data from different receive fields. | 03-19-2015 |
| 20150072446 | METHODS FOR TAILORING ELECTRODE WORK FUNCTION USING INTERFACIAL MODIFIERS FOR USE IN ORGANIC ELECTRONICS - The present invention is directed to methods for tailoring the work function of electrodes in organic electronics using interfacial modifiers comprising functionalized semiconducting polymers and/or small molecules. | 03-12-2015 |
| 20150060771 | ATOMISTIC QUANTUM DOTS - A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform. | 03-05-2015 |
| 20150055130 | Multilayered Tissue Phantoms, Fabrication Methods, and Use - A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighbouring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging. | 02-26-2015 |
| 20140378669 | METHODS FOR CONJUGATION OF OLIGOSACCHARIDES OR POLYSACCHARIDES TO PROTEIN CARRIERS THROUGH OXIME LINKAGES VIA 3-DEOXY-D-MANNO-OCTULSONIC ACID - Methods for preparing an oligosaccharide—protein carrier immunogenic conjugate or a polysaccharide—protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier. | 12-25-2014 |
| 20140349878 | PACLITAXEL RESPONSE MARKERS FOR CANCER - Cancer marker sets consisting of particular genes differentially expressed in tumours provide improved accuracy of predicting effectiveness of paclitaxel or paclitaxel-like drug treatment against a cancer. These sets are further useful for screening drug candidates for paclitaxel-like cancer treatment activity. The cancer marker sets may be used in a clinical setting to provide information about the likelihood that a cancer patient would or would not respond to paclitaxel or paclitaxel-like drug treatment. | 11-27-2014 |
| 20140341658 | LARGE SCALE SPALLATION INDUCING ICE PROTECTION - A technique for protecting a structure from an impact with ice involves providing a horizontal spall initiator extending from the wall a distance of 1 to 10 cm, the horizontal spall initiator being resilient to the ice impact, and formed by blade segments having a blade width less than ½ a thickness of an expected hard zone of the ice; and situating the horizontal spell initiator at an elevation of the expected hard zone. Situating the horizontal spall initiator at an elevation of the hard zone may involve providing an elevation control mechanism (e.g. buoyancy, mechanical, or hydrodynamic), or may involve a panel with a plurality of horizontal spell initiators at respective elevations. The horizontal spell initiator may be driven. | 11-20-2014 |
| 20140336953 | METHOD TO QUANTIFY EMISSION RATES IN ATMOSPHERIC PLUMES - A new method of making sky-LOSA measurements (Line-Of-Sight Attenuation measurements of sky-light) of soot mass flux in atmospheric plumes has been developed which enables accurate measurements in the presence of in-scattered light from the sky and sun. | 11-13-2014 |
| 20140330003 | DIACYLGLYCEROL ACYLTRANSFERASE 2 GENES AND PROTEINS ENCODED THEREBY FROM ALGAE - The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long-chain polyunsaturated fatty acids into triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds. | 11-06-2014 |
| 20140329021 | Method and Apparatus for Depositing Stable Crystalline Phase Coatings of High Temperature Ceramics - Producing high temperature coatings on ceramics using a high enthalpy air plasma spray torch and supplying in at least 3 passes to deposit the coating is advantageous for spraying high temperature ceramics while avoiding formation of undesirable phases, if the stand off distance is chosen such that a width of a bead produced from a single spray pass on the substrate at ˜800° C. is less than 70% of a diameter of a plume of the torch at the stand off, and neither assisted heating, nor forced cooling, nor subsequent heat treatment is used. The rapid cooling endemic to thermal spray that leads to amorphous, metastable and other undesirable phases of alkaline earth aluminosilicate (e.g., barium-strontium aluminosilicate (BSAS)), rare earth silicates (RESs), mullite, etc. can be mitigated sufficiently by the close stand off and high enthalpy torch to provide highly crystalline and stable phase coatings. | 11-06-2014 |
| 20140314813 | CLOSTRIDIUM DIFFICILE LIPOTEICHOIC ACID AND USES THEREOF - A novel lipoteichoic acid (LTA) was isolated from | 10-23-2014 |
| 20140302434 | Carrier Resins with Improved Relative Humidity Sensitivity - The disclosure describes acrylate carrier resins, optionally, with a C/O of at least about 4, comprising a heterocycle comprising sulfur, exhibiting high charge and improved RH sensitivity, carrier compositions comprising the acrylate-coated carriers and developers comprising a toner and the acrylate-coated carrier. | 10-09-2014 |
| 20140298535 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 10-02-2014 |
| 20140294517 | POWDER FEEDER METHOD AND SYSTEM - A powder fluidizing system, comprising a pressure vessel, a powder container removably mounted within the pressure vessel, and comprising a bottom sieve; a vibrator generating vibrations and transmitting the vibrations to the powder container above the sieve; and a guide directly secured under said powder container to the bottom sieve; wherein a bulk powder fed within the powder container is vibrated within the powder container and flows through the sieve to the guide, and a powder fluidizing method, comprising feeding a bulk powder within a powder reservoir maintained under pressure; vibrating the powder reservoir; and passing the powder through a sieve positioned at the bottom of the powder reservoir. | 10-02-2014 |
| 20140283204 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 09-18-2014 |
| 20140283203 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 09-18-2014 |
| 20140259216 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 09-11-2014 |
| 20140259197 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 09-11-2014 |
| 20140243441 | LADDER POLYMERS WITH INTRINSIC MICROPOROSITY AND PROCESS FOR PRODUCTION THEREOF - A polymer of formula (I): | 08-28-2014 |
| 20140242666 | VACCINE FOR SHIGELLA - Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an | 08-28-2014 |
| 20140242368 | PROCESS FOR PRODUCING ION EXCHANGE MEMBRANES BY MELT-PROCESSING OF ACIDIC PFSA IONOMERS - A process for producing an ion exchange membrane involves melt-processing a mixture of a perfluorosulfonic acid ionomer in its acid form and a specific azole additive. The additive may be a triazole, alkyl triazole, vinyl triazole, fluoro-alkyl triazole, fluoro-vinyl triazole, pyrazole, alkyl pyrazole, vinyl pyrazole, fluoro-alkyl pyrazole, fluoro-vinyl pyrazole, benzimidazole, alkyl benzimidazole, vinyl benzimidazole, fluoro-alkyl benzimidazole, fluoro-vinyl benzimidazole or any mixture thereof to form a film having a thickness of from 3 to 200 microns. Ion exchange membranes so produced have reduced in-plane-swelling, improved dimensional stability and mechanical properties, and are useful as electrolytes in proton exchange membrane fuel cells. | 08-28-2014 |
| 20140231379 | METHOD OF FABRICATING NANOTIPS WITH CONTROLLED PROFILE - A nanotip, is fabricated by modifying a precursor nanotip having an apex and a shank by applying an electric field in the presence of a reactive gas to perform field-assisted etching wherein atoms are preferentially removed from the shank by chemical interaction with the reactive gas, and controlling the reactive gas pressure and/or tip voltage to vary the electric field so as to promote field evaporation of apex atoms during fabrication of the nanotip and thereby control the overall profile of the resulting nano-tip. The method permits shaping of the overall tip profile. | 08-21-2014 |
| 20140212992 | CENTRIFUGALLY-ENHANCED CAPTURE METHOD AND DEVICE - In a centrifugal microfluidic device for conducting capture assays, a microfluidic platform rotates in a plane of rotation and has at least one capture surface for immobilizing a target particle of interest in the device. The capture surface oriented so that it is not parallel to the plane of rotation of the device and is positionally fixed in the device during operation of the device. The centrifugal force arising from rotation of the device forces the target particles against the capture surface. Capture efficiency is independent of the rate of flow of the fluid and independent of the rate of rotation of the microfluidic platform. | 07-31-2014 |
| 20140186924 | METHODS FOR TRANSFORMING TARWI AND FOR PRODUCING MOLECULAR FARMING PRODUCTS IN TRANSGENIC TARWI SEED - The present disclosure describes reproducible methods for the | 07-03-2014 |
| 20140184022 | POROSITY CONTROL IN PIEZOELECTRIC FILMS - A piezoelectric film having a porosity between 20 and 40%, a thickness ranging from tens of microns to less than a few millimeters can be used to form an ultrasonic transducer UT for operation in elevated temperature ranges, that emit pulses having a high bandwidth. Such piezoelectric films exhibit greater flexibility allowing for conformation of the UT to a surface, and obviate the need for couplings or backings. Furthermore, a method of fabricating an UT having these advantages as well as better bonding between the piezoelectric film and electrodes involves controlling porosity within the piezoelectric film | 07-03-2014 |
| 20140182382 | ULTRASONIC TRANSDUCER ASSEMBLY AND SYSTEM FOR MONITORING STRUCTURAL INTEGRITY - In an ultrasonic transducer assembly, a conformable ultrasonic transducer has a piezoelectric layer and electrodes able to conform to curved surfaces, and a clamp for pressing the transducer into ultrasonic contact with a curved surface. Conformability is ensured with a thin, porous piezoelectric layer and suitable electrical conductors and insulators. The ultrasonic transducer may operate without further thermal shielding under harsh environments and/or at high temperatures. | 07-03-2014 |
| 20140170726 | PHOTOBIOREACTOR - In the present invention, a photobioreactor and process for producing and harvesting microalgae involves a vessel for cultivating microalgae that is at least partially transparent to admit light into the vessel. At least a portion of the transparent part of the vessel is coated with a transparent conductive oxide (TCO) layer. The TCO layer is transparent to visible light necessary for algae growth, but is opaque to infrared light thereby reducing thermal heating load in the photobioreactor. The TCO layer also acts as an electrode, which when combined with a counter-electrode can provide a potential difference across at least a portion of the interior of the vessel between the TCO layer and the counter-electrode. The electrode arrangement can be utilized in an electrochemical process (e.g. electrodeposition and/or electroflotation) to dewater and harvest the microalgae in the same apparatus as the microalgae was cultivated. | 06-19-2014 |
| 20140154621 | TONER ADDITIVES - The disclosure relates generally to toner additives, and in particular, toner additives that provide desired higher toner charge and low relative humidity (RH) sensitivity. The toner additives comprise titania nanotubes or titania nanosheets in combination with or in place of the commonly used anatase or rutile crystalline titania. | 06-05-2014 |
| 20140141476 | GENES AND PROTEINS FOR ALKANOYL-COA SYNTHESIS - Polypeptides having alkanoyl-CoA activity have been identified and characterized, as have nucleic acids encoding these polypeptides. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds. | 05-22-2014 |
| 20140140990 | ANTIBODIES AGAINST KIDNEY ASSOCIATED ANTIGEN 1 AND ANTIGEN BINDING FRAGMENTS THEREOF - Novel antibodies and antigen binding fragments that specifically bind to KAAG1 and which may be used in the treatment, detection and diagnosis of cancer comprising KAAG1-expressing cells are disclosed herein. Cells expressing the antibodies and antigen binding fragments as well as methods of detecting and treating cancer using the antibodies and fragments are also disclosed. Cancer indications which may benefit from such treatment or detection include ovarian cancer, renal cancer, lung cancer, colorectal cancer, breast cancer, brain cancer, and prostate cancer, as well as melanomas. | 05-22-2014 |
| 20140134631 | CENTRIFUGAL MICROFLUIDIC PLATFORM - A centrifugal microfluidic device is provided having a microfluidic circuit, a fluid reservoir for providing fluid in the microfluidic circuit, a hydrodynamic resistance element in fluid communication with the reservoir for controlling rate of flow of a fluid out of the reservoir, and a siphoned chamber in fluid communication with the hydrodynamic resistance element and the microfluidic circuit for receiving fluid from the hydrodynamic resistance element and for delaying and metering of the fluid into the microfluidic circuit. The microfluidic device is useful for performing a biological assay. Operation of the device is completely independent on the liquid-solid contact angle and wetting properties of the liquids on the solid material of the platform, and the device does not need a carefully controlled rotation protocol. | 05-15-2014 |
| 20140121306 | Fire-Resistant Cellulosic Material - A new approach for improving fire resistance of cellulosic materials is provided, especially when the cellulosic material is to be used in polymer composites. Cellulosic material is treated with an aqueous mixture of alkali metal or ammonium hydroxide and alkaline earth or aluminum metal salt simultaneously with or within a short period of time of preparing the mixture. The treated cellulosic material becomes self-extinguishing and may also have improved thermal stability, improved interfacial thermal resistance, improved resistance to damage by oxidants and other chemical agents, improved resistance to biological agents and/or improved resistance to damage by ultra-violet light. The fire-resistant cellulosic material may also be treated with a layered nanoparticulate material either simultaneously with, subsequent to or prior to treatment with the aqueous mixture of alkali metal or ammonium hydroxide and alkaline earth or aluminum metal salt to impart further fire resistance to the cellulosic material. Polymer composites produced from cellulosic material treated according to the present invention have significantly improved fire resistance with small negative impact on the mechanical performance of the composite, and may have the added benefit of improved thermal stability, improved interfacial thermal resistance, improved resistance to damage by oxidants and other chemical agents, improved resistance to biological agents and/or improved resistance to damage by ultra-violet light. | 05-01-2014 |
| 20140113854 | Locally-Active Anticoagulants and Anti-Inflammatory Agents - A locally-activatable bivalent thrombin binding agent is provided having two thrombin binding moieties for non-overlapping sites on a surface of thrombin linked together by a linker. The linker is a polypeptide having 5 to 30 amino acid residues existing in a folded state under an environmental condition where the binding agent is inactive. The linker changes conformation from the folded state to an unfolded state in response to a change in bulk temperature and/or to the presence of hyper-mobile water thereby activating the binding agent. Such locally-activatable thrombin binding agents can be administered systemically while only targeting specific sites of coagulation or inflammation since the thrombin binding agent will only activate at the site where the existence of atherosclerotic plaques has changed the local bulk temperature and/or created hyper-mobile water sufficiently to unfold the linker and activate the binding agent. Such binding agents are useful as site-specific anti-coagulant, anti-thrombotic and/or anti | 04-24-2014 |
| 20140069160 | Low Friction End Feeding in Tube Hydroforming - An end plunger for end feeding during a hydroforming process (such as tube hydroforming) has at least one releasable seal. The effect of the releasable seal is that it avoids pressurizing the blank in a nip area, thereby reducing friction and wear, and allowing increased end feeding with a given end feeding force. The releasable seal may be actuable, for sealing or releasing. The plunger may be modular or monolithic. A kit and method may incorporate the end plunger. | 03-13-2014 |
| 20140051170 | Process, Vectors and Engineered Cell Lines for Enhanced Large-Scale Transfection - Processes, vectors and engineered cell lines for large-scale transfection and protein production in mammalian cells, especially Chinese Hamster Ovary (CHO) cells are described in which transfection efficiencies are realized through the use of a single vector system, the use of functional oriP sequences in all plasmids, the use of codon-optimized Epstein-Barr virus nuclear antigen-1 (EBNA1) constructs, the use of a fusion protein between a truncated Epstein-Barr virus nuclear antigen-1c (EBNA1c) protein and a herpes simplex virus protein VP16, the use of a 40 kDa fully deacetylated poly(ethylenimine) as a transfection reagent, the use of co-expression of a fibroblast growth factor (FGF) and/or the use of protein kinase B to potentiate heterologous gene expression enhancement by valproic acid (VPA). | 02-20-2014 |
| 20140038234 | Expression System With Sar Element From IFNalpha2 - A short human genomic nucleotide sequence from the SAR3 region of the human interferon α2 gene permits enhances expression stability in the absence of drug selection and permits generation of stable clones or stable pools of cells for producing recombinant proteins. Although stable clones may be generated, the ability to generate stable pools reduces the burden of generating stable clones. | 02-06-2014 |
| 20140011701 | Prognostic Marker Sets For Prostate Cancer - Prostate cancer marker sets consisting of particular genes differentially expressed in prostate tumours provide improved accuracy of prostate cancer prognosis. The prostate cancer marker sets of the present invention, one of which consists of 30 genes related to apoptosis, one of which consists of 22 genes related to cell cycle and one of which consists of 30 genes related to response to external stimulus, may be used in a clinical setting to provide information about the likelihood of a prostate cancer patient to survive without treatment (i.e. whether the prostate tumour is “good” or “bad”). | 01-09-2014 |
| 20140004568 | Method of Viral Production in Cells | 01-02-2014 |
| 20140004507 | Microfluidic System Having Monolithic Nanoplasmonic Structures | 01-02-2014 |
| 20130335154 | Frequency Stabilization of An Atomic Clock Against Variations of the C-Field - The frequency of an atomic clock may be stabilized against C-field variation by applying a rf magnetic field perpendicular to the C-field to cause a coherent population transfer between Zeeman states that compensates for quadratic frequency shift of transitions of the clock. The cancellation, provided by a feed-forward mechanism, is exact. The invention can be implemented in any atomic clock by including an electrode in the clock generating a magnetic field perpendicular to the C-field, and providing an electronic circuit to send rf signals to the electrode. | 12-19-2013 |
| 20130318661 | NUCLEIC ACID ENCODING N-METHYLPUTRESCINE OXIDASE AND USES THEREOF - The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells. | 11-28-2013 |
| 20130317130 | 3D Microfluidic Devices Based on Open-Through Thermoplastic Elastomer Membranes - The invention provides a new process for patterning TPE membranes for use in the design and fabrication of 3D microfluidic devices. The process involves patterning a TPE material without permitting the highest features of the mold to come into contact with the counter-plate, whereby adhesion between the TPE and the mold or counter-plate during demolding results directly in removal of the excess layer from the TPE membrane to produce well formed micrometric-sized open-through holes in the TPE membrane. The process permits rapid, reliable and efficient patterning of densely packed and arbitrarily placed micrometric open-through holes and channels of high aspect-ratio and any shape or wall profile in thin TPE membranes. | 11-28-2013 |
| 20130309749 | NUCLEIC ACID ENCODING N-METHYLPUTRESCINE OXIDASE AND USES THEREOF - The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells. | 11-21-2013 |
| 20130303406 | ENGINEERING OF IMMUNOGLOBULIN DOMAINS - The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a V | 11-14-2013 |
| 20130295086 | ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY - Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells. | 11-07-2013 |
| 20130272958 | ANTI-CEACAM6 ANTIBODIES AND USES THEREOF - The present invention relates to isolated or purified antibodies or fragments thereof specific for CEACAM6 and their use as therapeutic or diagnostic tools. Specifically, the present invention is directed to antibodies or fragments thereof specific for a linear epitope of CEACAM6. In vivo and in vitro methods of diagnosis as well as therapeutic methods are also described. | 10-17-2013 |
| 20130266564 | ANTIBODIES SELECTIVE FOR CELLS PRESENTING ErbB2 AT HIGH DENSITY - An erbB2 antibody is provided that binds preferentially to disease cells having an erbB2 density greater than a normal erbB2 density. The erbB2 antibody comprises a heavy chain and a light chain. Each chain has a constant region and a variable region. Each variable region comprises framework regions and complementarity determining regions (CDRs), wherein the CDRs have an amino acid sequence set forth below: For the heavy chain: CDR1 GFNIKDTYIH (SEQ ID No. 1) CDR2 RIYPTNGY | 10-10-2013 |
| 20130260049 | PROCESS FOR CHEMICAL PASSIVATION OF POLYMER SURFACES - Process for passivating polymeric particles to prevent undesirable interaction with the environment. In particular, sputter coating of metal and surface treatment with aqueous solutions are shown to successfully passivate the particles, such as for example, toner particles, and prevent interaction between the particles and the epoxy embedding resin which causes artifacts, observed by transmission electron microscopy (TEM) imaging. | 10-03-2013 |
| 20130251712 | COVALENTLY DIMERIZED BIVALENT BINDING AGENTS - The present invention addresses limitations of prior art receptor-based traps through a methodology called the clamp/click/cleave (CCC) approach. Two fusion proteins each comprising a binding domain fused to a coiled-coil are non-covalently dimerized through the coiled-coil (clamp), and the dimer so formed is stabilized by a covalent disulphide bond (click) between cysteine residues located on the fusion proteins between the binding domains and coiled-coils. Once the disulphide bond has formed, the coiled-coils are subsequently removed (cleave) by cleaving the fusions proteins at cleavage sites located between the cysteine residues and the coiled-coils to provide the covalently dimerized bivalent binding agent of the present invention. Such binding agents are useful in the treatment and diagnosis of disease states characterized by production and/or overexpression of a ligand to which the binding domains bind. The invention is particularly useful for covalently dimerized receptor-based ligand traps where the binding domains are receptor ligand-binding domains, such as those of TGF-β receptors. | 09-26-2013 |
| 20130245422 | Cognitive Function Assessment in a Patient - A method for analysis of the extent of conscious awareness and likelihood of recovery of a patient includes the steps of applying to the patient a sensory stimulus sequence which is typically auditory; carrying out an EEG to generate waveform signals to record changes in the electromagnetic fields generated by the patient's neural activity; using software provided in a processor to process the waveform signals in order to locate waveform peaks, identify the event-related potential (ERP) components obtained in the waveform and to obtain quantitative measures of those components; and using the software to generate and communicate scores indicative of the extent of conscious awareness and likelihood of recovery of the patient. | 09-19-2013 |
| 20130216381 | OSCILLATING FOIL TURBINE - An oscillating foil turbine has a foil having a first fluid dynamic surface for producing lift in a fluid flow, a support for the foil, and a second fluid dynamic surface, wherein the support allows for cyclic motion of the first and second surfaces with respect to each other. A driven member is provided to tap energy from flow throughout each cycle. Throughout at least part of the cyclic translation, the fluid dynamic surfaces are oriented sufficiently parallel, and separated by a distance that is sufficiently small, to achieve a substantial wing-in-ground effect. | 08-22-2013 |
| 20130209745 | METHOD OF COATING OF A SUBSTRATE WITH A THERMAL SPRAY COATING MATERIAL AND COATED SUBSTRATE FORMED THEREBY - A method of coating a surface of a substrate with a particulate coating material, the method comprising: determining at least an area of the surface of the substrate to be covered with the particulate coating material; subjecting at least a portion of the area of the surface of the substrate to laser irradiation to form a plurality of distinct spaced-apart laser impact craters in a pattern and/or at least one last impact pit on the surface of the substrate; and thermally spraying the area of the surface of the substrate with the particulate coating material. A coated substrate comprising: a substrate having a plurality of distinct spaced-apart laser impact craters in a pattern and/or at least one laser impact pit on at least an area of a surface of the substrate; a thermally-sprayed coating mechanically bonded to at least the area of the surface of the substrate. | 08-15-2013 |
| 20130200053 | LASER PROCESSING CONTROL METHOD - A control system for controlling a laser machining/processing apparatus and uses two separate control modules, each of which operates interdependently with the other. A laser control module contains instructions for controlling the laser beam while a movement control module contains instructions for controlling the movement of the laser apparatus relative to a workpiece. The instructions in each module are executed in parallel and interdependently of the instructions in the other module. The laser control module controls the actions of the laser apparatus while, in parallel, the movement control module controls the relative movements and/or positioning of the laser beam relative to the workpiece. Again, in parallel, the laser control module continuously checks the actual position of the laser apparatus against the desired position where laser action should be executed and, if the difference between the actual and the desired positions are within a predetermined margin of error, the relevant laser action is executed. | 08-08-2013 |
| 20130196381 | CELL-BASED PRODUCTION OF NANULOSONATES - The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose. Methods for producing the sugars are also provided. | 08-01-2013 |
| 20130195932 | ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS - The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca | 08-01-2013 |
| 20130188254 | THIN FILM OPTICAL FILTERS WITH AN INTEGRAL AIR LAYER - Novel thin film optical filters have an integral air layer. The frustrated total internal reflection (FTIR) phenomenon, combined with thin film interference, is used to effectively control the polarization properties of thin film coatings operating at oblique angles. The invention is applicable to high-performance thin film polarizing beam-splitters, non-polarizing beam-splitters, non-polarizing cut-off filters and non-polarizing band-pass filters, and any other thin film coatings that require the control of polarization effect. The low index layer offers an improvement in performance and the simplification of the thin film optical filter coating designs by reducing the total number of layers and the total layer thicknesses to minimize the angles of incidence and the size of the filter substrates, thereby minimizing the contact area and hence reducing the manufacturing costs. | 07-25-2013 |
| 20130182520 | MEMORY DEVICE BASED ON CONDUCTANCE SWITCHING IN POLYMER/ELECTROLYTE JUNCTIONS - A non-volatile memory device including at least a first electrode and a second electrode provided on a substrate, the first and second electrodes being separated from each other; an organic semiconductive polymer electrically connecting the first and second electrodes; an electrolyte in contact with the organic semiconductive polymer; and a third electrode that is not in contact with the first electrode, the second electrode, and the organic semiconductive polymer; wherein the organic semiconductive polymer has a first redox state in which it exhibits a first conductivity, and a second redox state in which it exhibits a second conductivity. | 07-18-2013 |
| 20130165396 | Apple Skin Extracts for Treating Cardiovascular Disease - Pharmaceutical and nutraceutical compositions and methods for treating cardiovascular disease, comprising apple skin extracts which can reduce cholesterol levels and inhibit low density lipoprotein (LDL) oxidation in a subject, are provided. | 06-27-2013 |
| 20130161271 | THIXOTROPIC INJECTOR WITH IMPROVED ANNULAR TRAP - By blocking an angular extent of an annular skimming trap used for semi-solid injection, a notable reduction in lenticular defects and porosity are observed. The blocking can be performed by a ring having dimensions to completely occlude a prior art annular skimming trap throughout the angular extent, and providing complete and/or partial flow across the ring throughout the rest of the angular extent. Preferably an outlet to the ring trap includes a chamfered edge and/or a deflector for encouraging flow of the contaminated semi-solid material into the trap. | 06-27-2013 |
| 20130158135 | Organogel Compositions Comprising Alkylated Aromatic Acids - Disclosed is a composition comprising an organogel which comprises: (a) an alkylated aromatic acid compound of the formula | 06-20-2013 |
| 20130156809 | Recombinant Bacterium and Uses Thereof - The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided. | 06-20-2013 |
| 20130153508 | Phase Selective Gelation With Alkylated Aromatic Acid Compounds - Disclosed is a process which comprises mixing an alkylated aromatic acid with a mixture comprising a first liquid and a second liquid, thereby causing formation of an organogel comprising the alkylated aromatic acid and the first liquid. | 06-20-2013 |
| 20130152230 | GENES ENCODING A NOVEL TYPE OF LYSOPHOPHATIDYLCHOLINE ACYLTRANSFERASES AND THEIR USE TO INCREASE TRIACYLGLYCEROL PRODUCTION AND/OR MODIFY FATTY ACID COMPOSITION - Described nucleic acid molecules (and corresponding peptides) encode lyso-phosphatidylcholine (LPC) acyltransferases. Over-expression of the LPC acyltransferases in a cell may lead to enhanced production of PUFA, or other unusual fatty acids, and/or to increased oil content in the cell. | 06-13-2013 |
| 20130150561 | SINGLE-DOMAIN BRAIN-TARGETING ANTIBODY FRAGMENTS DERIVED FROM LLAMA ANTIBODIES - A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-His | 06-13-2013 |
| 20130144072 | NUCLEOPHILIC SUBSTITUTION OF CARBON NANOTUBES - Compounds are attached to carbon nanotubes (CNT) by a process which comprises: subjecting surface treated CNTs which have been treated to induce negatively charged surface groups thereon, to nucleophilic substitution reaction with a compound carrying a functional group capable of reacting with the negatively charged groups on the CNT surface, whereby the compound chemically bonds to the CNT. The surface CNT treatment may be reduction. The compounds which are bonded to the CNT may be epoxy resins, bonded directly or through a spacer group. Bi-functional CNTs, grafted to both epoxy resins and other polymers such as polystyrene, are also made by this process. | 06-06-2013 |
| 20130142780 | METHOD FOR ISOLATION OF SOLUBLE POLYPEPTIDES - Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human V | 06-06-2013 |
| 20130139899 | SEMIPERMANENTLY CLOSED MICROFLUIDIC VALVE - A microfluidic valve operable to semi-permanently close a channel of a microfluidic device defined between a thermoplastic elastomer (TPE) film and a substrate operates employs a surface contact bond between the TPE and a wall of the channel. Thermomechanical release of the valve, tristate functionality, and repeated semi-permanent closure and release are demonstrated. | 06-06-2013 |
| 20130137822 | MODIFIED CARBON NANOTUBES AND THEIR COMPATIBILITY - Modified carbon nanotubes are provided having carbon nanotube core covalently bound through C—C bonds to a polymer shell surrounding the carbon nanotube core. The polymer shell is a polymer having functional groups pointing outwardly from the shell. The functional groups are compatible with or able to covalently connect to another polymer. Such modified carbon nanotubes are more readily dispersed in a homogeneous manner in another polymer and may be used as a reinforcing filler in a polymer matrix. The modified carbon nanotubes with a core-shell structure in which the core has a substantially unidirectional orientation within the shell are produced by reacting neutral carbon nanotubes with 4-vinylaniline through a diazonium reaction in presence of one or more types of multifunctional monomers carrying a vinyl moiety and one or more functional groups for compatibilization with or connection to another polymer. The reaction is conducted at an elevated temperature without isolation of intermediates and without addition of any extra initiator or catalyst to form a polymer shell in situ around the carbon nanotube. The polymer shell is covalently bound to CNT sidewall through C—C bonds and has functional groups outwardly pointing from the shell for compatibilization with or connection to another polymer. | 05-30-2013 |
| 20130129788 | Nanotubes and Compositions Thereof - The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes. | 05-23-2013 |
| 20130123375 | Organogel Compositions Comprising Alkylated Benzimidazolones - Disclosed is a composition comprising an organogel which comprises: (a) an alkylated benzimidazolone compound; and (b) an organic liquid. | 05-16-2013 |
| 20130122193 | Mold Halves with Metal-Matrix Composite At Feature Areas - A mold half, especially for blow molding of thermoplastic articles, has a mold body defined at least in part by a single piece of aluminum or aluminum alloy mold material having a cavity and a pinch-off or other feature area and further having a metal-matrix composite (MMC) layer formed integrally in the mold body at the pinch-off or other feature area. A mold is fabricated from two mated mold halves. A process of producing a mold half involves machining a single piece of mold material to provide a mold body having a cavity and a pinch-off or other feature area, the pinch-off or other feature area being of smaller dimension than required for the mold half, integrally forming a metal-matrix composite layer in the pinch-off or other feature area to build up the pinch-off or other feature area to at least a dimension required for the mold half. The metal-matrix composite comprises an aluminum-nickel alloy matrix (e.g. AI-12Si alloy alloyed with Ni) having WC particles embedded therein or a aluminum matrix (e.g. AI-12Si alloy) having TiC particles embedded therein and has greater wear resistance, greater strength, greater toughness or any combination thereof than the mold material. | 05-16-2013 |
| 20130090717 | NON-WOVEN MAT AND METHOD OF PRODUCING SAME - A mat having a highly uniform porosity distribution is produced by consolidating 15 or more layers of melt blown webs (or the like) having different orientations. Control over the porosity is provided by using webs that exhibit a narrow, unimodal distribution of fiber diameters over the bulk of its distribution, such as in the top 80%. A compliance of the mats can be chosen by selecting a number and orientation of the webs. It is thus possible to produce mats that are good candidates for vascular grafts, for example. The uniformity of the porosity within the range of 6 μm to 30 μm permits seeding of the vascular graft with endothelial and smooth muscle cells. The mats have the demonstrated ability to retain, and support growth of, smooth muscle cells and endothelial cells. | 04-11-2013 |
| 20130089896 | ALPHA-1, 4-GALACTOSYLTRANSFERASE (CGTD) FROM CAMPYLOBACTER JEJUNI - α-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from | 04-11-2013 |
| 20130089499 | ANTAGONISTS OF LIGANDS AND USES THEREOF - The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I: | 04-11-2013 |
| 20130088307 | ORTHOMODE TRANSDUCER - An orthomode transducer (OMT) operable in a broadband (e.g. >30%), including a frequency above ˜30 GHz, with an isolation better than −50 dB, cross-polarizations better than −40 dB, an insertion loss between −0.1 and −0.3 dB for both polarizations, and return losses better than −25 dB can be produced substantially or entirely from CNC machining, comprises a turnstile for coupling a polarization diplexed waveguide with four waveguide paths; and two E-plane Y junctions each for coupling initially oppositely directed pairs of the waveguide paths such that each waveguide path has a same electrical length from the turnstile to the E-plane Y junctions as the waveguide path with which it is paired, such that the OMT is formed in 3-6 blocks, including a single block having a substantially planar mating surface that includes the matching feature, and defines one side of initial segments of the four waveguide paths. Reproducibility of these OMTs has been shown. | 04-11-2013 |
| 20130064763 | ANTI-ICAM-1 SINGLE DOMAIN ANTIBODY AND USES THEREOF - Anti-ICAM-1 V | 03-14-2013 |
| 20120093819 | ANTIBODIES THAT SPECIFICALLY BLOCK THE BIOLOGICAL ACTIVITY OF A TUMOR ANTIGEN - Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, method of detecting and treating cancer using the antibodies and fragments are also disclosed. | 04-19-2012 |
| 20120071635 | METHODS AND COMPOSITIONS FOR MODULATING TUMOR CELL ACTIVITY - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin. | 03-22-2012 |
| 20120070541 | SYRUP AND SUGAR PREPARED FROM MAPLE SAP OR MAPLE SYRUP AND PROCESS FOR PREPARATION THEREOF - Natural maple saps and maple syrups are contacted with an immobilized isomaltulose-forming microorganism to convert at least 20% of the sucrose contained in the sap or syrup to isomaltulose. The microorganism may be immobilized on calcium alginate and prepared as a column through which sap or syrup flows. The resultant isomaltulose-containing solutions are concentrated to produce reduced or low glycemic index sugar syrups, semi-solid and solid sugar products. | 03-22-2012 |
| 20120041146 | PHENOL-FORMALDEHYDE POLYMER WITH CARBON NANOTUBES, A METHOD OF PRODUCING SAME, AND PRODUCTS DERIVED THEREFROM - The present invention provides methods to functionalize and solubilize WCNT with a phenolic polymer such as a lignin or a PF resin followed by in-situ integration of this functionalized CNT in the presence of formaldehyde and phenol and/or lignin to generate either CNT-reinforced phenol-formaldehyde polymer or CNT-reinforced lignin-phenol-formaldehyde polymer in either liquid or powder form suitable as an adhesive in the manufacture of a lignocellulosic composite material such as OSB and plywood. | 02-16-2012 |
| 20110318348 | INDUCTION OF MUCOSAL IMMUNE RESPONSES BY MUCOSAL DELIVERY PENTABODY COMPLEX (MDPC) - The subject invention provides, for example, a novel approach to specifically induce intranasal and/or oral mucosal as well as humoral antibody response by administrating a mucosal delivery pentabody complex (MDPC). The MDPC is a complex formed by mixing a target antigen and a mucosal delivery pentabody (MDP) that has a strong affinity to the target antigen. The MDP is a fusion protein of a single domain antibody (sdAb; which binds to the target antigen specifically) to a pentamerization domain (which can include the B-subunit of an AB5 toxin family, including the B subunit of cholera toxin (CT) or heat-labile toxin (LT)). The pentamerization domain can self-assemble into a pentamer, through which a pentameric single domain antibody, or a pentabody, is formed. | 12-29-2011 |
| 20110311813 | SELF-ASSEMBLED NANOSTRUCTURES - Nanostructures are formed from alkylated derivatives of aromatic acids of the formula: | 12-22-2011 |
| 20110306147 | Method of Multiple Spiking Isotope Dilution Mass Spectrometry - A comprehensive approach for interpretation of the multiple spiking isotope dilution results is described herein. It has now been found that a method of multiple spiking isotope dilution analysis for mass spectrometry is possible using an approach that permits precise and simultaneous characterization of m substances from a sample even if species inter-conversion (degradation and formation) has occurred prior to separation. Advantageously, initial and final amounts of involved analytes, conversion extent, conversion degree and rate constants from the results of a single quantitation experiment may be obtained with the present method. In a particularly advantageous embodiment, uncertainty in the characterization of the substances may be estimated more accurately by also estimating increase in the uncertainty due to interconversion of the analytes. | 12-15-2011 |
| 20110303122 | STERICALLY BULKY STABILIZERS - A sterically bulky stabilizer that includes an alkylated-benzimidazolone compound, where the sterically bulky stabilizer is associated non-covalently with a benzimidazolone pigment, and the presence of the sterically bulky stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 12-15-2011 |
| 20110282072 | SELF-ASSEMBLED NANOSTRUCTURES - An alkylated benzimidazolone compound of the formula: | 11-17-2011 |
| 20110277668 | STERICALLY BULKY STABILIZERS - A sterically bulky stabilizer that is associated non-covalently with a benzimidazolone pigment. The sterically bulky stabilizer compound includes an aromatic acid derivative, and the presence of the sterically bulky stabilizer limits an extent of particle growth and aggregation, to afford nanoscale pigment particles. | 11-17-2011 |
| 20110274617 | Antibody-Targeted Carrier For Contrast Agents - A nanoconjugate is formed from a self-assembled unilamellar vesicle (ULV), at least one contrast agent which may be a MRI contrast agent, a radioisotope or a fluorophore, and at least one antibody, which may be an IgG or an antibody fragment such as a single-domain antibody. The nanoconjugate be targetted with the antibody to receptors specific to certain disease states, and thus be used in diagnostic and imaging methods using the properties o contrast agent. | 11-10-2011 |
| 20110271874 | Nanosized Particles of Benzimidazolone Pigments - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is a substituted pyridine derivative; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 11-10-2011 |
| 20110269148 | Nanoaggregate Embedded Beads Conjugated To Single Domain Antibodies - A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological or environmental samples using Raman spectroscopy. | 11-03-2011 |
| 20110269039 | APPARATUS AND METHOD FOR CONTROLLING VARIABLE POWER CONDITIONS IN A FUEL CELL - A fuel cell comprises an anode having an inner face and an outer face fluidly communicable with a fuel; a cathode having an inner face ionically communicable with and physically separated from the anode inner face, and having an outer face fluidly communicable with an oxidant; and at least one movable guard movable over at least one of the anode outer face, cathode outer face, anode inner face, and cathode inner face. The guard has a structure sufficient to block at least part of one or more of the anode's communication with the fuel, the cathode's communication with the oxidant, and the ionic communication between the anode and cathode thereby reducing a maximum potential active area of the fuel cell to an effective active area of the fuel cell. | 11-03-2011 |
| 20110230430 | SAPONIN EXTRACT FROM SAPONARIA SPP. AND USES THEREOF - A saponin extract from | 09-22-2011 |
| 20110226962 | METHOD AND APPARATUS FOR DETECTING FLUORESCENCE EMITTED BY PARTICLE-BOUND FLUOROPHORES CONFINED BY PARTICLE TRAPS - A method of detecting a fluorescence signal emitted by fluorophores bound to particles confined in a particle trap, includes an objective lens having a focal plane, which is normally the focal plane for incident collimated light. The particle trap is typically located in the focal plane, and a beam of excitation light is directed via the objective lens onto the confined particles in the trap. The excitation light is in the form of a divergent beam coming to focus at a plane displaced from the focal plane. The divergent beam has a spot diameter at the focal plane determined by the divergence of the beam. The fluorescent light emitted by the fluorophores is detected with a confocal detector. | 09-22-2011 |
| 20110223107 | ANTIBODIES THAT SPECIFICALLY BLOCK THE BIOLOGICAL ACTIVITY OF A TUMOR ANTIGEN - Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, methods of detecting and treating cancer using the antibodies and fragments are also disclosed. | 09-15-2011 |
| 20110217244 | COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSE - The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid. | 09-08-2011 |
| 20110206905 | METHOD FOR FORMING A BLOCK COPOLYMER PATTERN - A method for forming a block copolymer pattern on a substrate, wherein the areal density of nanostructures in the pattern is increased by increasing the thickness of the block copolymer film that is applied to the substrate. | 08-25-2011 |
| 20110171686 | REVERSE CUMATE REPRESSOR MUTANT - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 07-14-2011 |
| 20110165582 | MOLECULAR METHOD FOR DIAGNOSIS OF COLON CANCER - Methods for diagnosing or detecting cancerous colon tissue. A panel of 17 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal human colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue. By using these 17 marker genes as a diagnostic tool, smaller tissue samples, such as those obtained by core needle biopsies, from patient stool samples, or from blood samples can be used. | 07-07-2011 |
| 20110143997 | PHAGE RECEPTOR BINDING PROTEINS FOR ANTIBACTERIAL THERAPY AND OTHER NOVEL USES - The subject invention relates in part to novel uses of bacteriophage tail spike proteins (TSPs). Some preferred uses are therapeutic uses in animals, such as chickens, against pathogenic bacteria, such as Salmonella. Fragments of the TSPs can also be used according to the subject invention, particularly protein fragments comprising the phage receptor binding domains (PRBDs), which recognize their hosts and facilitate infection. The binding domains are specific to unique surface structures on bacteria and may be used for a variety of applications according to the subject invention. We have shown that by utilizing these PRBDs, it is possible to exploit the long-established evolutionary relationship between bacteria and their viruses (ie bacteriophages) that specifically infect them. The subject invention also relates in part to novel, synthetic forms of tail spike proteins. In some preferred embodiments, these are hexamers. | 06-16-2011 |
| 20110135932 | Production of Sulfur-Free Nanoparticles by Yeast - A method of producing sulfur-free nanoparticles involves growing yeast in a growth medium containing a source of an element in a bio-reducible oxidation state (e.g. Se(V1), and, precipitating nanoparticles containing the element in a lower oxidation state (e.g. Se(O)) than the oxidation state of the element in the source. The method advantageously can provide substantially spherical nanoparticles at high production efficiencies. | 06-09-2011 |
| 20110111454 | ENGINEERED VERSIONS OF CgtB (Beta-1,3 GALACTOSYLTRANSFERASE) ENZYMES, WITH ENHANCED ENZYMATIC PROPERTIES - CgtB proteins with enhanced beta 1,3-galactosaminyltransferase activity, nucleic acids that encode the CgtB proteins and methods for use of the CgtB proteins. | 05-12-2011 |
| 20110098999 | TEXT CATEGORIZATION BASED ON CO-CLASSIFICATION LEARNING FROM MULTILINGUAL CORPORA - The present document describes a method and a system for generating classifiers from multilingual corpora including subsets of content-equivalent documents written in different languages. When the documents are translations of each other, their classifications must be substantially the same. Embodiments of the invention utilize this similarity in order to enhance the accuracy of the classification in one language based on the classification results in the other language, and vice versa. A system in accordance with the present embodiments implements a method which comprises generating a first classifier from a first subset of the corpora in a first language; generating a second classifier from a second subset of the corpora in a second language; and re-training each of the classifiers on its respective subset based on the classification results of the other classifier, until a training cost between the classification results produced by subsequent iterations reaches a local minima. | 04-28-2011 |
| 20110098371 | Proton-Conducting Polymeric Poly(Arylene Ether)s with Pendant Phenyl Sulfonic Acids - Disclosed are sulfonated polymers of formula (I) or a salt thereof: wherein X is (a) or (b), R is hydrogen or an organic moiety, n is an integer from 10 to 10,000, p is 1 or 2, and m is 0 or 1 for a particular monomer unit such that the polymer has a degree of sulfonation of 0.50 or greater. Such polymers are useful in proton exchange membranes (PEMs) having high ion exchange capacity with higher proton conductivity than Nafion™, while having lower methanol permeability and lower water uptake than previously disclosed polymers. | 04-28-2011 |
| 20110093983 | ALGAL GLYCEROL-3 PHOSPHATE ACYLTRANSFERASE - The present disclosure relates to the isolation of, purification of, characterization of, and uses for a glycerol-3-phosphate acyltransferase (TpGPAT1), and genes encoding TpGPAT1, from algae. | 04-21-2011 |
| 20110091874 | ULTRASENSITIVE DETECTION OF TARGET USING TARGET-READY PARTICLES - The invention relates to methods and reagents for detecting minute amounts of targets having affinity for nucleic acid. The present invention more particularly relates to target detection using aggregates of cationic polymer chains and nucleic acid capture probes linked to particles, such as controllable mobility particles. | 04-21-2011 |
| 20110088124 | REDUCTION OF LYSO-PHOSPHATIDYLCHOLINE ACYLTRANSFERASE ACTIVITY - Reducing lyso-phosphatidylcholine acyltransferase (LPCAT) activity in a plant increases seed oil content and/or fatty acid levels in the plant. Increases in the level of unusual fatty acids 16:3, 18:3 and 20:1c11 are particularly pronounced. | 04-14-2011 |
| 20110084251 | ATOMISTIC QUANTUM DOT - A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed therefrom. | 04-14-2011 |
| 20110083586 | CONTROLLED RELEASE OF CHEMICAL ADMIXTURES - A method of controlling release of an admixture in a cement-based composition involves intercalating an admixture (e.g. an accelerator, a set retarder, a superplasticizer) for the cement-based composition into a layered double hydroxide or mixture thereof. A cement-based composition prepared in such a manner and containing a cement-based material (e.g. cement, mortar or concrete) has better workability, especially in respect of slump-loss characteristics. | 04-14-2011 |
| 20110068361 | HIGH PERFORMANCE LIGHT-EMITTING DEVICES - A light emitting device in the form of a layered structure has a passive bottom multilayer stack including a cathode layer, a cavity layer including a light emitting region, a passive top multilayer stack including a hole transport layer, and a transparent anode layer. The passive bottom and top multilayer stacks are devoid of a light emitting layer. A transparent substrate, through which light is emitted from the device, is located over the top multilayer stack. At least one functional additional layer group in the passive top multilayer stack controls the reflectance of the passive top multilayer stack and phase changes occurring upon reflection from the passive top multilayer stack in the cavity layer. | 03-24-2011 |
| 20110060045 | ANTI-DIABETIC CATARACT COMPOUNDS AND THEIR USES - The invention disclosed relates to the use of anti-glycation agents of formula (I), | 03-10-2011 |
| 20110052565 | NON-AGGREGATING HUMAN VH DOMAINS - The present invention relates to non-aggregating VH domains or libraries thereof. The V | 03-03-2011 |
| 20110033471 | METHODS AND COMPOSITIONS FOR MODULATING TUMOR CELL ACTIVITY - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin. | 02-10-2011 |
| 20110021610 | AROMATIC PRENYLTRANSFERASE FROM HOP - Nucleic acid molecules from hop ( | 01-27-2011 |
| 20110003084 | Process of Making Ceria-Based Electrolyte Coating - It has been surprisingly found that injecting ceria-based particles (mean size less than 200 nm) suspended in a combustible organic solvent into a plume having a maximum temperature between about 2,600° C. and 4,000° C. to impart a mean temperature to the particles from about 2,600° C. to about 3,800° C., and to accelerate the particles to a mean velocity between about 600 to 1000 m/s, produces a thin, uniform, dense, crack-free, nanocrystalline ceria-based coating, which may be applied on porous cermet or metal substrate, for example. The physical environment of a high-velocity oxy-fuel (HVOF) thermal spraying gun suitably ably deployed using standard fuels produces these conditions. The method of the present invention is particularly useful for the cost-effective fabrication of ceria-containing electrolytes for solid oxide fuel cells (SOFCs). | 01-06-2011 |
| 20110002854 | Use of Francisella Tularensis For Prevention and Treatment of Allergic Airway Disorders - A pharmaceutical composition for treating or preventing a Th | 01-06-2011 |
| 20100290037 | PRISM COUPLED SILICON ON INSULATOR SENSOR - Methods and devices related to a sensor element for use in the detection and monitoring of molecular interactions. The sensor element uses a silicon-on-insulator wafer optically coupled to a silicon prism. The wafer has a thin silicon film top layer, a silicon substrate layer, and a buried silicon dioxide layer sandwiched between the silicon film and substrate layers. The wafer is coupled to the prism on the wafer's substrate side while the interactions to be monitored are placed on the wafer's silicon film side. An incident beam is directed at the prism and the incident angle is adjusted until the beam optically couples to the silicon film's optical waveguide mode. When this occurs, a decrease in the intensity of the reflected beam can be detected. The molecular interactions affect the phase velocity or wave vector of the propagating mode. Similarly, instead of measuring the incident angle at which optical coupling occurs, the phase of the reflected beam may be measured. | 11-18-2010 |
| 20100225497 | Surface-Mounted Crack Detection - A cementitious compound provides a brittle undercoat for making a surface-mounted crack sensor on a surface. A low percent elongation and low tensile strength of the cementitious compound have proven valuable in ensuring that cracks in the underlying surface are transmitted through the undercoat so that a trace of conductive ink or paint on the undercoat more reliably detects the crack. | 09-09-2010 |
| 20100167349 | ORF11 FROM CAMPYLOBACTER JEJUNI IS A SIALATE-O-ACETYLTRANSFERASE - The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides. | 07-01-2010 |
| 20100151354 | Membraneless Fuel Cell And Method Of Operating Same - A direct fuel cell comprises a cathode comprising electroactive catalyst material; and an anode assembly comprising an anode having a porous layer and electroactive catalyst material in the porous layer. The electrode characteristics of the anode assembly are selected so that fuel supplied to the anode is reacted within the anode so that cross-over from the anode to the cathode does not have more than a 10% negative effect on voltage or a 25 mV voltage loss when at peak power and steady state conditions. The anode and cathode each have a first major surface facing each other in non-electrical contact and without a microporous separator or ion exchange membrane therebetween. | 06-17-2010 |
| 20100110443 | PLANAR WAVEGUIDE WAVELENGTH DISPERSIVE DEVICES WITH MULTIPLE WAVEGUIDE INPUT APERTURE - A spectrometer has a multi-input aperture for admitting an input wavefront and an array of multiple waveguide structures terminating at the multi-input aperture. The input wavefront is incident on each of the waveguide structures, which provide a dispersive function for the input wavefront. Interferometers are formed by elements of the waveguide structures. The interferometers have different optical path length differences (OPDs). The interferometers provide a wavelength responsive output for spatially extended light sources. The output of the interferometers is detected with a detector array. The spectrometer has an improved etendue, and in some embodiments very high resolution. | 05-06-2010 |
| 20100104963 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is a substituted pyridine derivative; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 04-29-2010 |
| 20100087614 | NUCLEOPHILIC SUBSTITUTION OF CARBON NANOTUBES - Compounds are attached to carbon nanotubes (CNT) by a process which comprises: subjecting surface treated CNTs which have been treated to induce negatively charged surface groups thereon, to nucleophilic substitution reaction with a compound carrying a functional group capable of reacting with the negatively charged groups on the CNT surface, whereby the compound chemically bonds to the CNT. The surface CNT treatment may be reduction. The compounds which are bonded to the CNT may be epoxy resins, bonded directly or through a spacer group. Bi-functional CNTs, grafted to both epoxy resins and other polymers such as polystyrene, are also made by this process. | 04-08-2010 |
| 20100069604 | BLOCK FUNCTIONALIZATION METHODS - Epoxy resins are chemically attached to carbon nanotubes (CNTs), in a one-step process in which a reaction mixture comprising the epoxy polymer, the CNTs and a bridging agent which is a chemical compound capable of forming living polymers, e.g. styrene or MMA is formed and radical formation is initiated in the reaction mixture; the epoxy polymer or monomer grafts onto the CNTs through the intermediary block of the bridging agent. | 03-18-2010 |
| 20100063140 | WATER-SOLUBLE COMPOSITIONS OF BIOACTIVE LIPOPHILIC COMPOUNDS - Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: | 03-11-2010 |
| 20100037955 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated derivative of an aromatic acid; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 02-18-2010 |
| 20100035172 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated-benzimidazolone compound; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 02-11-2010 |
| 20100012844 | IDENTIFICATION OF IMMUNOGLOBULIN (Ig) DISORDERS USING FOURIER TRANSFORM INFRARED SPECTROSCOPY - A method and a corresponding system for obtaining a serum mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) are described. The method comprises acquiring FTIR spectra for dried sera and preprocessing the FTIR spectra of sera by differentiation and smoothing to enhance weak spectral features and to remove baseline variations. The preprocessed FTIR spectra are normalized to a common intensity range, the normalization being performed in a spectral sub-region defined by strongest infrared (IR) absorption for a protein to obtain the serum spectroscopic profile. The serum spectroscopic profiles provide a basis to diagnose immunoglobulin disorders or to quantify serum immunoglobulin levels. | 01-21-2010 |
| 20100004360 | METHODS OF MAKING NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - Nanoscale particles of benzimidazolone pigments are made by providing one or more organic pigment precursor(s) to a benzimidazolone pigment, providing a solution or suspension of a sterically bulky stabilizer compound that associates non-covalently with a benzimidazolone moiety on one of the pigment precursors, wherein the sterically bulky stabilizer compound is selected from the group consisting of substituted pyridine derivatives, alkylated benzimidazolone compounds, alkylated derivatives of aromatic acids, and mixtures thereof, and carrying out a coupling reaction to form a benzimidazolone pigment composition, whereby one or more functional moieties on the benzimidazolone pigment is non-covalently associated with the sterically bulky stabilizer, so as to limit an extent of particle growth and aggregation and results in nanoscale pigment particles. | 01-07-2010 |
| 20090286288 | ALPHA-1, 4-GALACTOSYLTRANSFERASE (CgtD) FROM CAMPYLOBACTER JEJUNI - α-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from | 11-19-2009 |
| 20090246832 | PRODUCTION OF POLYSIALIC ACID CONTAINING GLYCOCONJUGATES USING A SELF-PRIMING POLYSIALYLTRANSFERASE - The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins. | 10-01-2009 |
| 20090236544 | UV REACTIVE SPRAY CHAMBER FOR ENHANCED SAMPLE INTRODUCTION EFFICIENCY - An analyte for atomic spectrometry detection is prepared by introducing an aerosol of the analyte into a chamber, and irradiating the aerosol with ultraviolet light in the presence of a low molecular weight organic acid or other suitable photoactivatable ligand donor species to create vapor containing the analyte. The vapor containing the analyte is extracted from the chamber and used for atomic spectrometry detection. | 09-24-2009 |
| 20090215116 | Identification of a beta-1,3-N-acetylgalactosaminyltransferase (CGTE) from campylobacter jejuni LIO87 - The invention relates to β-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides. | 08-27-2009 |
| 20090215115 | SIALYLTRANSFERASES COMPRISING CONSERVED SEQUENCE MOTIFS - The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including α-2,3-sialyltransferase proteins from | 08-27-2009 |
| 20090211632 | PHOTOVOLTAIC DEVICE BASED ON CONFORMAL COATING OF COLUMNAR STRUCTURES - A photovoltaic device, comprises a first electrode, an electron donor layer in electrical contact with the first electrode, an electron acceptor layer in contact with the electron donor layer across an interface having a shape defined by a columnar structure grown by oblique angle deposition, and a second electrode in electrical contact with the electron acceptor layer. | 08-27-2009 |
| 20090210959 | METHOD FOR PRODUCTION OF SAPONARIA FROM MICROSPORES | 08-20-2009 |
| 20090187388 | METHOD AND SYSTEM FOR LOCATING LANDMARKS ON 3D MODELS - A plurality of landmarks are automatically located on a 3-dimensional polygonal mesh of connected vertices. A probabilistic graph is generated for the plurality of landmarks pre-identified on each of a first set of 3-dimensional models. The graph represents local surface characteristics for each landmark and relational positions between neighboring pairs of landmarks. Local surface characteristics are determined for each vertex of the mesh. For each landmark, a set of the vertices is identified that satisfies a criteria based on a surface difference between the vertex local surface characteristics and the landmark local surface characteristics. A relational position for each pair of vertices from the sets of vertices corresponding to the neighboring pairs is determined based on the graph. One of the vertices is determined for each of the plurality of landmarks to minimize the surface difference and the relational difference for the landmark. | 07-23-2009 |
| 20090176275 | EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 07-09-2009 |
| 20090121125 | Blind Extraction of Pure Component Mass Spectra from Overlapping Mass Spectrometric Peaks - A method of obtaining pure component mass spectra or pure peak elution profiles from mass spectra of a mixture of components involves estimating number of components in the mixture, filtering noise, and extracting individual component mass spectra or pure peak elution profiles using blind entropy minimization with direct optimization (e.g. downhill simplex minimization). The method may be applied to deconvolution of pure GC/MS spectra of overlapping or partially overlapping isotopologues or other compounds, separation of overlapping or partially overlapping compounds in proteomics or metabolomics mass spectrometry applications, peptide sequencing using high voltage fragmentation followed by deconvolution of the obtained mixture mass spectra, deconvolution of MALDI mass spectra in the separation of multiple components present in a single solution, and specific compound monitoring in security and/or environmentally sensitive areas. | 05-14-2009 |
| 20090020710 | SEMICONDUCTOR NANOCRYSTALS FOR TIME DOMAIN OPTICAL IMAGING - A method of performing high repetition rate laser time domain imaging employs as fluoroprobes semiconductor nanocrystals having a fluorescence lifetime less than the laser pulse separation, typically less than 5 ns. The nanocrystals of the invention have a core/shell structure and may be surface treated to increase radiative decay. CdSe/Zns nanocrystals are particularly suitable. | 01-22-2009 |
| 20080317780 | VIRAL VACCINE AND METHOD FOR PREPARATION THEREOF - The invention relates to a viral vaccine, especially a retroviral vaccine, and methods of forming such a vaccine. The vaccine is formed from a whole-killed virus suspension in a cell lysate or culture medium, wherein the virus is killed by exposure to a chloramine compound at a level adequate to inactivate zinc finger proteins. The chloramine compound may be taurine chloramine, adenosine chloramine, phenylalanine chloramine, and alanine chloramine. The vaccine may be used as a prophylactic or therapeutic vaccine and may be developed from a subject's own strains of virus so as to be considered an autologous vaccine. | 12-25-2008 |
| 20080314122 | MONITORING OF LEAKAGE IN WASTEWATER FORCE MAINS AND OTHER PIPES CARRYING FLUID UNDER PRESSURE - A method of detecting leakage in a force main involves placing at least two spaced sensors on the force main. Liquid is pumped through the pipe by means of a pump. The pump is shut down for an interval of time, and during the period following pump shutdown while negative pressure is present in the pipe, signals are generated at the sensors due to noise or vibration resulting from fluid being drawn into the pipe. The position of a leak in the pipe is determined by correlating the leak noise signals generated while the pipe is under negative pressure. Alternatively, the invention can be applied to a pressurized pipe, in which case conditions of negative pressure can be deliberatively created for a period to draw in fluid from the outside. | 12-25-2008 |
| 20080311618 | Expression System, Components Thereof and Methods of Use - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 12-18-2008 |
| 20080254188 | FORMULATIONS OF LIPOPHILIC BIOACTIVE MOLECULES - This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages. | 10-16-2008 |
| 20080248094 | VACCINE ADJUVANT PROPERTIES OF LIPSOMES FORMED AT ELEVATED TEMPERATURES FROM THE POLAR CHLOROFORM EXTRACTABLE LIPIDS FROM MYCOBACTERIUM BOVIS - The invention relates to a liposome comprising a chloroform soluble and extractable total polar lipid of Mycobacterium spp, particularly a chloroform soluble extractable total polar lipid of Mycobacterium bovis BCG. The chloroform soluble and extractable polar lipid may comprise at least one of phosphatidylinositol (PI), phosphatidylinositol mannoside (PIM | 10-09-2008 |
| 20080242754 | LOW LOSS FOAM COMPOSITION AND CABLE HAVING LOW LOSS FOAM LAYER - The invention relates to a low loss foam composition and cable, such as a coaxial cable. The foam composition is formed by heating an olefinic polymer, such as a high density polyethylene, medium density polyethylene, low density polyethylene, linear low density polyethylene, polypropylene, or a combination thereof, into a molten state composition, optionally with a nucleating agent. The molten mixture is extruded under pressure through a die with a blowing agent comprising an atmospheric gas, such as carbon dioxide, nitrogen or air, and a co-blowing agent selected from hydrofluorocarbons, hydrochlorofluorocarbons, or perfluoro compounds, such as HFC-134a. The cable is formed by extruding the foam composition onto a signal carrying conductor and sheathing the foam-coated signal carrying conductor in an appropriate conducting shield. | 10-02-2008 |
| 20080237576 | Voltage Controlled Computing Element for Quantum Computer - A computing element for use in a quantum computer has at least three coupled quantum dots, and at least one gate for applying an electric field to manipulate the state of said qubit. | 10-02-2008 |
| 20080220028 | ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS - The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca | 09-11-2008 |
| 20080207801 | Compatibilization of Polymer Clay Nanocomposites - A polymer nanocomposite contains layered clay dispersed in a polymer matrix together with compatibilizers for the clay and polymer matrix. The compatibilizers are a combination of two or more graft polymers. One graft polymer has high functionality and short chain length and another graft polymer has low functionality and long chain length. Such polymer nanocomposites have improved dispersion and better strength and modulus, while maintaining good toughness and impact strength. The polymer nanocomposites are particularly useful in applications where good mechanical performance and light-weight are of importance. | 08-28-2008 |
| 20080200339 | Synthesis and Biological Activity of Bicyclic Aba Analogs - Bicyclic abscisic acid (ABA) analogs of Formula (I) and (II) and the process for their production are disclosed. The bicyclic ABA analogs include the structural elements and functional groups of the parent molecule that are required for activity, and have an aromatic ring fused to the ring replacing the vinyl methyl group of absicisie acid. Methods for using the bicyclic ABA analogs to inhibit cell growth and seed germination are also disclosed. | 08-21-2008 |
