MILLIPORE CORPORATION Patent applications |
Patent application number | Title | Published |
20130284669 | NEGATIVELY CHARGED POROUS MEDIUM FOR REMOVING PROTEIN AGGREGATES - A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution. | 10-31-2013 |
20130092622 | NANOFIBER CONTAINING COMPOSITE MEMBRANE STRUCTURES - A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens. | 04-18-2013 |
20130062523 | DEVICES AND METHODS FOR INFRARED (IR) BASED QUANTITATION OF BIOMOLECULES - The present invention provides methods for quantitating one or more biomolecules in a sample using IR based techniques, sample holder devices for use in such methods as well as methods for manufacturing such sample holder devices. | 03-14-2013 |
20120297899 | Chromatography Apparatus And Method - Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples. | 11-29-2012 |
20120288630 | Novel Coated Membranes and Other Articles - The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane. | 11-15-2012 |
20120174996 | Manifold For A Device For Filtration With A Set Of Least One Filter Cassette - The invention concerns a manifold comprising: an auxiliary block ( | 07-12-2012 |
20120160342 | Bag For A Circuit Of A Biological Liquid Treatment Installation - The invention concerns a bag comprising a first conduit ( | 06-28-2012 |
20120156757 | PURIFICATION OF IMMUNOGENS USING A NON-POLYSACCHARIDE MATRIX - The present invention relates, at least in part, to novel and improved chromatography matrices for separating or purifying immunogens, such as, for example, viruses and viral surface proteins, from one or more contaminants in a sample, where the matrix comprises a porous non-polysaccharide solid support comprising a negatively charged, multivalent ion exchange group directly attached to the solid support. | 06-21-2012 |
20120145616 | Bag For A Circuit Of A Biological Liquid Treatment Installation - The invention concerns a bag comprising a first conduit ( | 06-14-2012 |
20120138522 | Device For A Biological Liquid Treatment Installation - The invention concerns a device comprising a base; a circuit comprising a bag comprising two flexible films and conveying network connectors, and a press ( | 06-07-2012 |
20120138467 | Electrodeionization Device And Method Comprising Control Of The Electric Current By Measurement Of Ion-Exchange Material Expansion | 06-07-2012 |
20120138173 | Device For A Biological Liquid Treatment Installation - The invention concerns a device comprising a base ( | 06-07-2012 |
20120118919 | FEED BAG CONSTRUCTION - A bag construction is provided comprising a bag, a first conduit sealed to the feed bag, an impeller device secured within the bag and extending from the first conduit in the bag to a second end and a one piece cap that is removably mounted on the first conduit. Optionally, the bag has a second conduit sealed to the interior of the bag for supplying wash reagent such as gas or a liquid to the bag. The impeller device is driven to cause all material in the bag to flow out the first conduit. | 05-17-2012 |
20120111782 | Device For Filtration With A Set Of Least One Filter Cassette - The invention concerns a filtration device comprising a manifold ( | 05-10-2012 |
20120097416 | WIRELESS RECEPTOR FOR COMMUNICATIONS WITHIN HOUSINGS - The present invention provides a system and method for transmitting information between a device within a housing to a second device, preferably a test or monitoring unit, outside of the housing. There are numerous issues associated with transferring information from within a sealed housing to an external device. In some cases, the use of wires inside the housing may be impractical, due to internal conditions, such as fluid flow, pressure or temperature. In one embodiment, the antenna of the external RF reading device is electrically connected to the dome of the housing. In another embodiment, the device within the housing is electrically connected to a housing component. In another embodiment, the gasket is used to pass information from within the housing to an external device. | 04-26-2012 |
20120095178 | Process For Treatment Of Residual Nucleic Acids Present On The Surface Of Laboratory Consumables - The invention relates to a new process for treatment of residual nucleic acids present on the surface of laboratory consumables. This process combines two treatment phases:
| 04-19-2012 |
20120091072 | REMOVAL OF MICROORGANISMS FROM FLUID SAMPLES USING NANOFIBER FILTRATION MEDIA - A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly | 04-19-2012 |
20120091012 | CONVERTER FOR USE WITH SENSING DEVICES - A system and method are disclosed for utilizing sensors with existing devices. An interface module is used in combination with a newer sensor, such as a fluorescence oxygen sensor, and an older legacy device. The older legacy device supplies a polarizing voltage, and anticipates a measured current of between 0 and 100 nA. The newer sensor requires no polarizing voltage and delivers an output of 0-10 volts in one embodiment, and 4-20 mA in another embodiment. The interface module receives the output from the sensor, and converts it into a useable signal to the legacy device. In another embodiment, the interface module comprises a number of outputs, such that both legacy devices and newer devices can be in communication with the sensor simultaneously. The interface module can be used in conjunction with a reactor chamber or other pharmaceutical process. | 04-19-2012 |
20120088262 | CYANINE COMPOUNDS, CONJUGATES AND METHOD OF USE - Cyanine compounds having the general formula I, conjugates, complexes, and compositions comprising the cyanine compounds are provided. Fluorescence resonance energy transfer (FRET) dye pairs and viability dyes are also provided. | 04-12-2012 |
20120088228 | METHODS OF PRODUCING HIGH TITER, HIGH PURITY VIRUS STOCKS AND METHODS OF USE THEREOF - The purity and titer of virus stocks used for virus clearance studies have a significant influence on study outcome, and impact how well the scale-down model represents the production-scale process. Impurities in virus stocks are particularly important in the testing of small virus retentive filters because these impurities may cause a filter to foul prematurely, leading to underestimation of the true throughput capability of the filter and consequent inappropriate sizing of the production scale unit. In addition, impurities can also affect the levels of virus clearance observed by altering the fouling mechanisms and subsequent fluid passage through the virus filter. Described herein are methods for making, producing and using high purity virus stocks having high titer. | 04-12-2012 |
20120077249 | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines - A method of purifying biomolecules with an anion exchanger containing a membrane having a surface having a polymer such as a primary or secondary amine ligand formed thereon, such as polyallylamine. The feedstock is introduced to the exchanger in the presence of one or more ionic-modifiers by themselves or in combination with monovalent salt. The ionic modifier alters the binding ability of the primary amines such that they retain a significant binding capacity for highly charged species such as DNA but lose part or almost all of their binding capacity for less charged species such as viruses or proteins at pH above the pI of the virus or protein. | 03-29-2012 |
20120076934 | ULTRAFILTRATION MEMBRANES AND METHODS OF MAKING - The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer. | 03-29-2012 |
20120070836 | METHODS OF DETECTING RESIDUAL AMOUNTS OF POLYMERS USED IN THE PURIFICATION OF BIOMOLECULES - The present invention relates to methods of detecting residual amounts of polymers including stimulus responsive polymers, which are used in processes for purifying biomolecules such as, for example, proteins, polypeptides, antibodies, vaccines and the like. | 03-22-2012 |
20120066649 | DATA ANALYSIS AND TARGET VISUALIZATION REPORTING TOOL - A web based customizable data analysis and visualization tool for providing target profiling services having a system, method, and computer software and reporting tool for processing data. The web based system maintains a first kinome profiling services database and a second GPCR profiling services database. The web based system, upon receiving appropriate operator commands, automatically processes either from the kinome profiling services database and/or GPCR profiling services database, or through a user's data provided in a supplied template, and provides a visual map of the results against a kinome or GPCRome, which show the familial relationships among kinases and GPCRs. respectively. The processing automatically performed by the web based system relates to (but is not limited to) kinome target profiling mapping. GPCRome target profiling mapping, document mapping and production, protein names and/or gene symbol aliases, target descriptions, gene and/or protein related content, target product, and a data navigator. Other web based functions and capabilities include the ability to utilize targetome maps and the like, to visualize data generated by the system. | 03-15-2012 |
20120062243 | Conductivity Measurement Device, Its Manufacture And Use - The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. | 03-15-2012 |
20120061463 | USE OF GAMMA HARDENED RFID TAGS IN PHARMACEUTICAL DEVICES - A system and method for utilizing RFID tags in environments where radiation is used is disclosed. RFID tags are secured to various components of a pharmaceutical system, thereby enabling the customer to download pertinent information about the component, such as lot number, date of manufacturer, test parameters, etc. The tags can be applied to the component immediately after manufacture and can be subjected to the sterilization process without risk of data loss or corruption. The memory device within the tag utilizes a technology that does not rely upon charge storage as its mechanism to store information. | 03-15-2012 |
20120061346 | Conductivity Measurement Device, Its Manufacture And Use - The invention relates to a method of manufacturing a device for measuring conductivity of a liquid, in particular ultrapure water, of the kind comprising two conductivity measurement electrodes suitable for defining a cell constant enabling the measurement of the conductivity of the ultrapure liquid, characterized in that it consists of producing each of the electrodes by forming an electrode pattern from electrically conductive material on a substrate of insulating material. | 03-15-2012 |
20120061332 | METHOD FOR RETROVIRUS REMOVAL - A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat. | 03-15-2012 |
20120031839 | FILTER WITH MEMORY, COMMUNICATION AND CONCENTRATION SENSOR - The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are coupled so as to be able to measure and transmit the concentration of a particular substance within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the concentration sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of concentration values. The use of this device is beneficial to many applications. For example, the ability to read concentration values in situ allows integrity tests to be performed without additional equipment. | 02-09-2012 |
20120031510 | Pump Cart For A Biological Liquid Treatment Installation - The invention concerns a pump cart for a biological liquid treatment installation, having a first lateral face ( | 02-09-2012 |
20120029176 | Chromatography Media And Method - Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs). | 02-02-2012 |
20120027324 | Disposable Vortex Breaker - The present invention consists of a closed presterilized bag having a disposable mixing element within it, a drive mechanism outside of the bag for rotating the mixing element without voiding sterility and a vortex breaker in the form of one or more plastic sheet materials that are attached to various inner surfaces of the bag and disrupt the formation of vortices within the bag. Preferably the sheet(s) are formed of the same material as the bag and are sealed to the bag surfaces. More preferably, the sheet(s) extend across a diameter of the bag. Most preferably, the sheet(s) are perforated with one or more slits or openings to allow for good flow and mixing without a vortex being formed. | 02-02-2012 |
20120024787 | Novel Coated Membranes and Other Articles - The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane. | 02-02-2012 |
20120018018 | Circuit For Biological Liquid - The invention concerns a circuit comprising a bag ( | 01-26-2012 |
20120017942 | Module For Purifying A Fluid Containing A Cleaning Agent, And Methods Of Fabricating And Using This Kind Of Module - The invention consists in a disposable module ( | 01-26-2012 |
20120006752 | Enhanced Clarification Media - Media and devices, such as nitrocellulose-based filters, wherein the media is coated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 01-12-2012 |
20120006751 | Enhanced Clarification Media - Media and devices, such as depth filters including such media, wherein the media is impregnated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples. | 01-12-2012 |
20120006736 | Device For A Biological Liquid Treatment Installation - The invention concerns a device comprising:
| 01-12-2012 |
20120001424 | Connection Devices And Male-Female Connection System Comprising Them - The male connection device comprises a sleeve ( | 01-05-2012 |
20120001423 | Connection Devices And Male-Female Connection System Comprising Them - The male connection device comprises a sleeve ( | 01-05-2012 |
20120000566 | RIGID DISPOSABLE FLOW PATH - The present invention provides a disposable rigid flow path which by itself or in conjunction with a clam shell or manifold system provides additional pressure resistance for the disposable device. In a first embodiment, the device is comprised of a first sheet of rigid plastic material and a second sheet of plastic material. Each sheet has a first major surface and a second major surface and a thickness between the first and second major surfaces. At least one and preferably both have flow channels formed in them. The flow channels are formed in the sheet(s) in manner such that the area of the sheet where the flow channels are formed extend away from the first major surface of the sheet and beyond the normal plane of the second major surface of the sheet. The first and second sheets are liquid tightly sealed to each other at their adjoining first major surfaces. In the embodiment where each sheet contains a flow channel, the flow channels of the two sheets are aligned and in register with each other. One or more fittings are secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets so as to function as an inlet, outlet or other port for the system. In another embodiment tubing is placed in the channels before the sheets are secured to one another. | 01-05-2012 |
20110318744 | Method For The Detection And Characterization Of Microorganisms On A Filter - The present invention relates to a method for the specific detection on a filter of one or more microorganisms present in a fluid, characterized in that it comprises the following steps:
| 12-29-2011 |
20110315625 | DETECTION OF MICRO-ORGANISMS - Improved methods and devices for detecting microorganisms, such as yeast and bacteria in mixtures, are disclosed. Methods include passing a sample mixture thorough a filter device, which has been pretreated with detergent resuspending the filtrand from the filter membranes and detecting the presence of microorganisms in the filtrand. | 12-29-2011 |
20110313066 | STIMULUS RESPONSIVE POLYMERS FOR THE PURIFICATION OF BIOMOLECULES - The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules. | 12-22-2011 |
20110311762 | ROOM TEMPERATURE STABLE AGAROSE SOLUTIONS - The present invention provides porous functionalized crosslinked polysaccharide hydrogel coated structures and methods for making the same. The methods include impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing, water, a polysaccharide having a concentration in the aqueous solution from about 0.1% to about 20%, a gel-inhibiting agent having a concentration in the aqueous solution from about 18 to about 54%, and an anionic fluorosurfactant having a concentration in the aqueous solution from about 0.001% to about 10% by total weight of the aqueous solution. Followed by evaporating the water from the polysaccharide coating; and exposing the dehydrated polysaccharide coating to a gelling agent form a porous polysaccharide hydrogel coated substrate. The hydrogel coated substrate is exposed to a crosslinking agent to form a porous crosslinked polysaccharide hydrogel coated substrate, which is then functionalized by the attachment of a ligand. | 12-22-2011 |
20110303592 | Filtration Device with Pressure-Activated Means for Bypassing Serial Filter Layers - A serial-flow filtration device is provided with pressure-activated means for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated means capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer. The bypass means can be embodied, for example, as a pressure-breachable seal or as a pressure-activated gate. | 12-15-2011 |
20110301333 | REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS USING CALCIUM PHOSPHATE SALTS - The present invention provides novel and improved compositions containing calcium phosphate and methods of using the same for the removal of protein aggregates from biopharmaceutical compositions containing a product of interest, e.g., a therapeutic antibody or protein. | 12-08-2011 |
20110284395 | Simultaneous Electrochemical Detection of Multiple Heavy Metal Ions in Liquid - Among others, techniques and systems are disclosed for detecting trace levels of heavy metal ions in a sample liquid. A voltage is applied to a sample liquid that includes metal complexes. A current signal associated with the metal complexes is measured. The measured current signal is processed to simultaneously detect a presence of two or more metal ions associated with the metal complexes. | 11-24-2011 |
20110283513 | Integrity Testable Multilayered Filter Device - The present invention relates to a device having two or more separate filtration layers that can be independently tested for integrity yet which allow for serial filtration through the two or more layers to obtain the desired characteristics such as retention. The device is made of two or more filtration areas, each containing one filter layer. Each area has one filtration layer and a first endcap bonded to a first end of the filter and a second endcap bonded to a second end of the filter. The areas are arranged concentrically around each other such that the first area is inward of the second area which is inward of a third area and the like. Each area is formed separately and integrity tested separately before final assembly. The first area is slid into the inside of the second area and then the two endcaps are either bonded to each, bonded to a third overall endcap or overmolded by a third endcap. | 11-24-2011 |
20110283502 | SEALING MEANS, KIT AND METHOD FOR SEALING OF HOLLOW HOSES OF FLEXIBLE MATERIAL - The present invention relates to sealing means made of a plastically deformable material for mechanical sealing of hollow hoses ( | 11-24-2011 |
20110281771 | POLYMERIC MEMBRANES WITH HUMAN SKIN-LIKE PERMEABILITY PROPERTIES AND USES THEREOF - The present invention provides synthetic membranes which are suitable as a human skin substitute for the investigation of transdermal diffusion of candidate pharmaceutical and cosmetic compounds. The membranes according to the present invention exhibit human skin-like permeability properties with respect to the diffusion of a wide range of compounds having widely different physico-chemical properties. | 11-17-2011 |
20110273272 | System And Method To Determine Sterilization Of A Device - A system and method for verifying the occurrence of an environmental condition is disclosed. Rather than store information concerning the occurrence and/or success of the sterilization process, the present invention modifies the wireless transmission characteristics of the device. In some embodiments, the bandwidth of the wireless transceiver is altered as a result of undergoing sterilization. In other embodiments, the resonance frequency of the circuit is affected. In other embodiments, one or more of these parameters are affected based on other environmental conditions, such as shock or vibration. | 11-10-2011 |
20110266204 | MANIFOLD ADAPTOR PLATE FOR FILTRATION APPARATUS - A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used. | 11-03-2011 |
20110256025 | IMMUNOASSAY PRODUCT AND PROCESS - The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so. | 10-20-2011 |
20110253233 | Fluid Transfer Device And System - Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position. | 10-20-2011 |
20110247971 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 10-13-2011 |
20110247429 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 10-13-2011 |
20110245352 | Composition For Permeabilizing The Walls Of Microorganisms Comprising The Combination Of Ethylenediaminetetraacetic Acid (EDTA) And Polyethyleneimine (PEI) - The present invention relates to a composition for permeabilizing the walls of microorganisms, comprising the combination of polyethyleneimine (PEI) and ethylenediaminetetraacetic acid (EDTA), and to a method using said composition for counting and detecting, in a targeted manner, the microorganisms on a membrane. The invention also relates to a kit comprising probes suitable for implementing said method. | 10-06-2011 |
20110244578 | Method For The Calibration Of A Device For Measuring Total Organic Carbon Content - The invention relates to a method for the calibration of a device for measuring the total organic carbon content (TOC) of an aqueous solution by measuring resistivity, comprising the following steps, in the presence of a reference TOO analyzer:
| 10-06-2011 |
20110244127 | METHOD OF FORMING COATED STRUCTURES - A process for forming room temperature water soluble polymer coatings on porous substrates by a solution of a room temperature water soluble polymer, one or more crosslinkers, a solvent for the room temperature water soluble polymer such as water and optionally one or more porogens, or functional agents, stirring the mixture until all the components are dissolved, adding the solution to a porous structure such as a non-woven fabric or a porous membrane and drying the solution on to the substrate as a coating before subjecting the coating to crosslinking. Alternatively, the coating may be partially crosslinked before drying the solution. Porous structures having a room temperature water soluble polymer coating and being capable of convective flow through the pores of the structure and diffusive flow through the coating can be formed. | 10-06-2011 |
20110235948 | FLEXIBLE PINCH FITTING FOR CONTAINERS - A device for reducing or eliminating the dead space in a fitting and tubing used on a disposable container by using a flexible elastic fitting that can accommodate a pinch valve or a clamp or the like closer to the flange portion of the fitting. The fitting is formed of a flange and a neck portion with a bore running through them. The neck may terminate in either a tubular section or a hose barb. The neck end section especially when in the form of a hose barb can be reinforced to provide a platform for attaching a tubing to it. | 09-29-2011 |
20110233422 | PARTICLE OR CELL ANALYZER AND METHOD - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles. | 09-29-2011 |
20110226964 | PARTICLE OR CELL ANALYZER AND METHOD - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles. | 09-22-2011 |
20110206559 | Decontamination Method And System Implementing It - The method of microbiological decontamination of a machine comprising an enclosure ( | 08-25-2011 |
20110206540 | Liquid Dispensing System With Enhanced Mixing - A dispense apparatus and system for dispensing suspensions or emulsions. The system ensures uniformity of distribution of the dispersed phase within the continuous-phase liquid by moving the fluid through the dispense cartridge, such as with a continuous or pulsating flow. In one embodiment, peristaltic pumps are positioned upstream and downstream of the dispense cartridge, in fluid communication with and forming a single loop with a fluid source. Circulation between the fluid source and the dispense cartridge is maintained. In a second embodiment, a pump circulates fluid into and out of the dispense cartridge and is also in fluid communication with a fluid source such as with a pinch valve to allow proper filling of the dispense cartridge from the fluid source. In a third embodiment, a reversing pump is placed between the dispense cartridge and fluid source to continually or continuously pump fluid into and out of the dispense cartridge. | 08-25-2011 |
20110201513 | PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF - The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured. | 08-18-2011 |
20110201100 | SINGLE USE CELL CULTURE BIOREACTOR MANIFOLD SYSTEM - The invention provides a disposable cell culture bioreactor manifold system for use in coupling sensors, fluid samplers, conduits, and the like, to a cell culture bioreactor in a sterile manner. The disposable bioreactor manifold system includes an externally attachable bioreactor manifold connector body for fluidly attaching modular sensor arrangements that measure physical variables and other parameters of medium contained within a bioreactor, as well as medium sampling components, and other connections, as well as at least one conduit fluidly connecting connecting the bioreactor manifold connector body with a pump for pumping fluids between the bioreactor and the bioreactor manifold connector body. | 08-18-2011 |
20110197989 | DISPOSABLE, STERILE FLUID TRANSFER DEVICE - The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place. | 08-18-2011 |
20110197971 | Water Purification System And Method - The invention concerns a water purification system ( | 08-18-2011 |
20110189725 | Microbiological Analysis Assembly And Method - The assembly comprises a filtration unit ( | 08-04-2011 |
20110189703 | High Throughput Cell-Based Assays, Methods of Use and Kits - In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the plate is placed into a carrier plate having open wells in register with the wells of the filter plate or one may use a wicking device or an underdrain attached to the bottom of the filter plate. Sufficient wash liquid is added to allow for filtration by the effect of gravity to occur. Cells are retained within the wells at a rate of 4 times that of other rapid methods. | 08-04-2011 |
20110185552 | Method For Improved Scaling Of Filters - Method of reducing performance variability of membrane scaling devices. Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly. | 08-04-2011 |
20110174735 | Unit And Method For Preparing A Sample For The Microbiological Analysis Of A Liquid - The unit comprises a filter membrane ( | 07-21-2011 |
20110174716 | Installation For Treating A Biological Liquid - Installation for treating a biological liquid, including a circulation pump ( | 07-21-2011 |
20110174711 | Self Contained Disposable Tangential Flow Filtration Liner - Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as an optional sensor mount. The liners and filtration element are independently compressed, so that decompression of the overall assembly does not decompress the liners and filtration element, thereby preventing leakage of hold-up volume within the fluid paths of the filtration element and liners. | 07-21-2011 |
20110142863 | FLOW THROUGH PURIFICATION PROCESSES FOR LARGE BIOMOLECULES - The present invention relates, at least in part, to novel and improved flow-through purification processes for separating large biomolecules, such as, for example, encapsulated viruses, virus-like particles and conjugate vaccines from one or more contaminants in a sample, where the process employs the use of at least one population of a solid porous particle which comprises a minimized external surface area per unit volume of the particles and an internal surface area per unit volume which is not decreased by more than 25% relative to a population of a similar particle which does not have a minimized external surface area. | 06-16-2011 |
20110127203 | Disposable Tangential Flow Filtration Liner With Sensor Mount - Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path. | 06-02-2011 |
20110121946 | ANTENNA GASKET FOR PROCESS HOUSINGS - A method and apparatus for providing wireless communication and optionally power to the interior of a housing assembly is disclosed. In one embodiment, an antenna is molded within a gasket material, such as silicon, so as to be completely encapsulated. The gasket preferably includes at least one support arm, which holds the antenna toward the middle of the housing, so as to minimize interference from the metal housing. In further embodiments, an inductive coil is encapsulated in the gasket. An alternating current is passed through this coil to create a changing magnetic field, which can then be used to create electrical power in physically separate components, such as filtering elements. In certain embodiments, multiple loops are molded to correspond to multiple filtering elements within the housing. | 05-26-2011 |
20110120565 | Reservoir For Liquid Dispensing System With Enhanced Mixing - Reservoir for a dispense system designed to maintain a suspending fluid flow within the reservoir. The fluid dispense system is particularly well suited to be manufactured in a single-use format comprising a fluid reservoir and fill tube assembly, particularly comprising a reservoir, tubing, fittings and connectors, and a needle. The system ensures uniformity within the liquid by moving the fluid through the product reservoir such as with a continuous or pulsating flow, and is designed to maintain the fluid in motion in order to maintain a homogenous solution. The reservoir is designed to minimize any fluid dead zones. | 05-26-2011 |
20110116342 | METHOD FOR SCALING MIXING OPERATIONS - A method for determining mixing time for a variety of vessels is disclosed. This method utilizes information about the configuration, such as vessel diameter, impeller diameter and speed, fluid density and viscosity, and fluid height to determine the appropriate mixing time. In another embodiment, the parameters used to create small batches of material can be used to scale up to larger vessel sizes. | 05-19-2011 |
20110105730 | AFFINITY CHROMATOGRAPHY MATRICES AND METHODS OF MAKING AND USING THE SAME - The invention provides methods of coupling protein ligands to a solid support. The invention also provides affinity chromatography matrices and methods of using affinity chromatography matrices to purify a target molecule. | 05-05-2011 |
20110100134 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 05-05-2011 |
20110094951 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 04-28-2011 |
20110094310 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 04-28-2011 |
20110085746 | FEED BAG CONSTRUCTION - A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit. | 04-14-2011 |
20110084024 | FILTER WITH MEMORY, COMMUNICATION AND CONCENTRATION SENSOR - The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are coupled so as to be able to measure and transmit the concentration of a particular substance within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the concentration sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of concentration values. The use of this device is beneficial to many applications. For example, the ability to read concentration values in situ allows integrity tests to be performed without additional equipment. | 04-14-2011 |
20110083491 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 04-14-2011 |
20110081661 | Modified photoproteins with increased affinity for calcium and enhanced bioluminescence and uses thereof - The present invention provides modified photoproteins, e.g., modified Clytin, having an increased affinity for calcium as well as an enhanced bioluminescence and their use as calcium indicators in reporter gene systems and in cell-based assays. | 04-07-2011 |
20110068812 | Method And Device For Measuring The Purity Of Ultrapure Water - This is a method for analyzing the purity of water at the outlet from a purification device. It comprises the following steps: a) sending the liquid at the outlet from the filter means ( | 03-24-2011 |
20110065901 | Methods For Purifying A Target Protein From One or More Impurities In A Sample - The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition comprising the Fc region containing protein and one or more impurities, where the methods eliminate the need for a holding tank and/or a buffer exchange step. | 03-17-2011 |
20110065110 | Method For The Extraction And Purification Of Nucleic Acids On A Membrane - The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine (NLS) making it possible to implement this method. | 03-17-2011 |
20110063602 | DIFFERENTIATION OF FLOW CYTOMETRY PULSES AND APPLICATIONS - A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window. | 03-17-2011 |
20110062073 | Thermoplastic injection molding method for capping a tubular filtration medium - A method for over-molding a tubular filter element | 03-17-2011 |
20110049042 | Porous adsorptive or chromatographic media - A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments. | 03-03-2011 |
20110045493 | Hydrophilic, High Protein Binding, Low Fluorescence, Western Blotting Membrane - Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding, excellent retention of protein sample spot morphology, and extended dynamic range (high signal-to-noise ratio, enhanced sample detectability). The membrane demonstrates comparable or higher performance in Western blotting applications than conventional nitrocellulose Western blotting membranes, particularly for protein detection at low sample concentrations, and is directly water-wettable, eliminating the need for an alcohol pre-wet step prior to use. | 02-24-2011 |
20110043164 | POWERED CARTRIDGES AND OTHER DEVICES WITHIN HOUSINGS - The present invention describes a system and method for supplying electrical power to a device, such as a filter element, located within a housing. In one embodiment, a conductive coil is embedded into the housing base, and a second coil is embedded into the filter element. Current is then passed through the coil in the housing base. Through induction, a current is created in the second coil in the filter element, in much the same way as a transformer functions. This inductive field may interfere with the operation of the various electronic functions, such as communications, sensing or other activities. To overcome this issue, an energy storage component, such as a capacitor, is included in the filter electronics. In this way, the power generated by the inductive field can be stored, and used when the inductive field is no longer present. | 02-24-2011 |
20110041619 | Device For Determining A Physical Value Of A Liquid Flowing In A Pipe - A device for determining a physical value of a liquid flowing in a pipe, without contact with said liquid, said device comprising:
| 02-24-2011 |
20110038757 | IMMUNOASSAY PRODUCT AND PROCESS - The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips, and other such devices is preferred in doing so. | 02-17-2011 |
20110036782 | FILTER WITH MEMORY, COMMUNICATION AND TEMPERATURE SENSOR - The present invention describes a system and method for accurately measuring the temperature of a filter element. A temperature transducer, and a communications device are coupled so as to be able to measure and transmit the temperature of a filter element while in use. This system can comprise a single component, integrating both the communication device and the temperature transducer. Alternatively, the system can comprise separate temperature transducer and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of temperature values. The use of this device is beneficial to many applications. For example, the ability to read filter temperatures in situ allows improved Sterilization-In-Place (SIP) protocol compliance, since the temperatures of actual filter elements can be directly measured, rather than interpolated as is done currently. | 02-17-2011 |
20110031178 | WIRELESS ENABLED DEVICE - The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry. | 02-10-2011 |
20110026560 | FILTER WITH MEMORY, COMMUNICATION AND TEMPERATURE SENSOR - The present invention describes a system and method for accurately measuring the temperature of a filter element. A temperature transducer, and a communications device are coupled so as to be able to measure and transmit the temperature of a filter element while in use. This system can comprise a single component, integrating both the communication device and the temperature transducer. Alternatively, the system can comprise separate temperature transducer and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of temperature values. The use of this device is beneficial to many applications. For example, the ability to read filter temperatures in situ allows improved Sterilization-In-Place (SIP) protocol compliance, since the temperatures of actual filter elements can be directly measured, rather than interpolated as is done currently. | 02-03-2011 |
20110024375 | Device For Supporting A Plurality of Flexible Containers For Liquid - A device for supporting a plurality of flexible containers ( | 02-03-2011 |
20110020327 | Purification of proteins - The present invention relates to a bimodal polymer such as a soluble polymer capable of irreversibly binding to insoluble particulates and a subset of soluble impurities and also capable of reversibly binding to one or more desired biomolecules in an unclarified biological material containing stream and the methods of using such a material to purify one or more desired biomolecules from such a stream without the need for prior clarification. Such a polymer comprises domains of charged pendant groups such as primary, secondary, tertiary or quaternary amines, (first mode) and is rendered insoluble and precipitates out of solution simply upon complexing with oppositely charged solid particulates and a fraction of the soluble impurities in an amount sufficient to form an aggregate that can no longer be held in solution. The polymer further comprises other domains of pendant groups that are charged or uncharged, hydrophilic or hydrophobic or have a ligand that is selective for the biomolecule of interest depending on the process conditions such as pH, ionic strength, salts, and the like (second mode). When present in one mode, such as the uncharged form, said pendant groups are capable of binding to one or more desired biomolecules within the stream (protein, polypeptide, etc) in an unclarified cell broth. The precipitate can then be removed from the stream, such as by being filtered out from the remainder of the stream and the desired biomolecule is recovered such as by selective elution. | 01-27-2011 |
20110020181 | FILTER WITH MEMORY, COMMUNICATION AND CONCENTRATION SENSOR - The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are coupled so as to be able to measure and transmit the concentration of a particular substance within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the concentration sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of concentration values. The use of this device is beneficial to many applications. For example, the ability to read concentration values in situ allows integrity tests to be performed without additional equipment. | 01-27-2011 |
20110017062 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 01-27-2011 |
20110016953 | FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR - The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible. | 01-27-2011 |
20110000789 | Electrodeionization Method and Device With Hydrodynamic Flow Splitting - Method for the removal of ions and ionizable substances from a polar liquid ( | 01-06-2011 |
20100328865 | WIRELESS RECEPTOR FOR COMMUNICATIONS WITHIN HOUSINGS - The present invention provides a system and method for transmitting information between a device within a housing to a second device, preferably a test or monitoring unit, outside of the housing. There are numerous issues associated with transferring information from within a sealed housing to an external device. In some cases, the use of wires inside the housing may be impractical, due to internal conditions, such as fluid flow, pressure or temperature. In one embodiment, the antenna of the external RF reading device is electrically connected to the dome of the housing. In another embodiment, the device within the housing is electrically connected to a housing component. In another embodiment, the gasket is used to pass information from within the housing to an external device. | 12-30-2010 |
20100326212 | Disposable, pre-sterilized fluid receptacle sampling device - The present invention provides a fluid sampling device comprising a port insert, a plurality of flexible conduits, and a plurality of sample containers. The port insert comprises a body having a plurality of shafts therethrough and a rotatably displaceable member for individually opening and closing any of said shafts to enable the flow of fluid therethrough. Flexible conduits (e.g., flexible tubing) are equal in number to the shafts, with each flexible conduit connected to or otherwise in fluid communication with an individual shaft. Similarly, sample containers (e.g., flexible bags) are equal in number to the conduits, with each sample container connected to an individual conduit opposite the connection to the shaft. A specific configuration for the port insert, as well as kit containing sterilized components of the fluid sampling device, are also described. | 12-30-2010 |
20100323430 | Media For Membrane Ion Exchange Chromatography - Media for chromatographic applications, wherein the media is a membrane having a surface coated with a polymer such as a polyethyleneimine. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary ammonium functionality to the media. The media is well suited for chromatographic purification of virus. | 12-23-2010 |
20100307967 | FILTRATION DEVICE - The present invention provides a vacuum filter device ( | 12-09-2010 |
20100305759 | Verification And Control Device And Method For At Least One Water Purification System - The verification and control method for at least one water purification system comprises: a step of supplying, by a server embedded with said water purification system, an editing interface comprising a zone for selecting items of exploitation information representing physical quantities associated with the water purification system, a step of selecting, via said first remote browser, at least one said item of exploitation information to constitute at least one exploitation interface page, a step of sending a request to access a said exploitation page, by said second remote browser, to said server, a step of collecting the value of each physical quantity represented by a selected item of information to constitute said page, and a step of supplying, by said server, said page comprising each said collected value. | 12-02-2010 |
20100305312 | Method For The Extraction And Purification Of Nucleic Acids On A Membrane - The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine (NLS) making it possible to implement this method. | 12-02-2010 |
20100291706 | DYE CONJUGATES AND METHODS OF USE - The present invention relates to cyanine compounds, compositions comprising them, articles of manufacture, and methods of making and using them. The cyanines usefully comprise one or more carboxyl groups or derivatives thereof that are indirectly attached to an aryl ring on an alkylaryl cyanine substituent. Also provided are conjugates of the disclosed cyanines and one or more other substances. Solvates, solutions, and derivatized forms of the cyanines are also provided. The cyanines find use in a variety of bioassays, both in direct single-label applications and in energy transfer formats. Methods utilizing the disclosed cyanines for analyzing a sample for a target are provided. Also disclosed are detection complexes comprising the disclosed cyanines, as well as compositions and articles comprising the cyanines in an excited state, for example formed by direct excitation or by energy transfer. The cyanines may be used as alternatives to other known optically active species in a variety of settings. Other embodiments are described further herein. | 11-18-2010 |
20100288690 | STACKED PLATES FILTRATION CARTRIDGE - A filtration cartridge ( | 11-18-2010 |
20100282350 | Sealing means, kit and method for sealing of hollow hoses of flexible material - The present invention relates to sealing means made of a plastically deformable material for mechanical sealing of hollow hoses ( | 11-11-2010 |
20100264041 | CONVERTER FOR USE WITH SENSING DEVICES - A system and method are disclosed for utilizing sensors with existing devices. An interface module is used in combination with a newer sensor, such as a fluorescence oxygen sensor, and an older legacy device. The older legacy device supplies a polarizing voltage, and anticipates a measured current of between 0 and 100 nA. The newer sensor requires no polarizing voltage and delivers an output of 0-10 volts in one embodiment, and 4-20 mA in another embodiment. The interface module receives the output from the sensor, and converts it into a useable signal to the legacy device. In another embodiment, the interface module comprises a number of outputs, such that both legacy devices and newer devices can be in communication with the sensor simultaneously. The interface module can be used in conjunction with a reactor chamber or other pharmaceutical process. | 10-21-2010 |
20100255476 | Composition For Increasing Microorganism Wall Permeability And Method For Detecting Said Microorganisms On A Membrane - The present invention relates to a composition for permeabilizing microorganism walls, comprising the combination of polyethyleneimine (PEI) with at least one alcohol, and also to a method using said composition for counting and detecting in a targeted manner the microorganisms on a membrane. The invention also relates to a kit and to probes that are suitable for carrying out said method. | 10-07-2010 |
20100243556 | High-throughput asymmetric membrane - A microporous asymmetrical membrane formed of one or more layers wherein the “tight” side of the membrane has an “opened” face or otherwise highly-porous reticulated surface is described. The microporous asymmetrical membrane has high throughput and high flux, even when used for filtering viscous materials, such as serum or plasma. The membrane's surface can be formed by ablation or solvation, or in a two or more layered structure, through an appropriate selection of casting dopes. | 09-30-2010 |
20100243087 | System and pump apparatus for processing fluid samples - A pump is provided having a disposable bladder and disposable conduits together with check valves that control fluid flow through the bladder and conduits when the bladder is alternately compressed and expanded. The use of disposable conduits and bladder eliminates the need for hygienically regenerating the pump between uses. The pump can be utilized in a fluid delivery system such as tangential flow filtration. | 09-30-2010 |
20100237013 | AUTONOMOUS FILTER ELEMENT - An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics or parameters of the fluid, such as temperature, pressure, or flow rate. In response to the measured characteristic or parameter, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response to this, the control logic may initiate a specific response designed to alleviate the blockage. This response may be a temperature change, a vibration, a change in fluid flow path, or some other action. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation. | 09-23-2010 |
20100235896 | Instrument access control system - A system for centrally managing a set of network-connected laboratory instruments is disclosed. For example, the system includes a centralized database that includes information about the instruments in the system and about the authorized users of the system. In particular, the centralized database indicates which users are authorized to use each of the instruments in the system. The database may also include information about the operations that each user is authorized to perform using the instruments and information indicating whether tests performed by each instrument must be signed using one or more electronic signatures. The system may recognize a number of “roles,” each of which is associated with a particular set of rights, and may assign one or more roles to each user. Instruments and other elements of the system may access the centralized database over a network to enforce the user rights represented by the information in the database. | 09-16-2010 |
20100233034 | Universal filter plate - The present invention relates to a multiwell plate having a series of wells, each well having an inner bore, an open top and a bottom, the bottom being sealed with a liquid permeable filter, and an insert contained within the inner-bore of each well, each insert having an outer dimension the same or larger than that of the inner bore and a through bore of a dimension less than that of the outer dimension of the insert. The use of inserts allows one to take a standard one-piece plate design with a heat sealed membrane and arrange for a universal plate format. The insert may act as a base for an extension plate that can be adhered, heat sealed or overmolded over the plate top and insert top to form a deep well plate. The plate conforms to the Society of Biological Standards Microplate Standards. Additionally, the inserts may be configured to give one a different well diameter (smaller, tapered, etc), to include various media such as chromatography resins, to include multiple layers of membrane and the like. A variety of inserts may be used in the same plate to create a minilab on a plate that is capable of conducting several steps of a process on the same (e.g (e.g. filter, wash, bind, elute, label, etc). | 09-16-2010 |
20100227015 | Method and apparatus for making porous agarose beads - The present invention relates to a method and apparatus for forming agarose or cored agarose beads. The process involves dissolving/gelation the agarose in a suitable liquid, mixing it with a hydrophobic liquid to form an emulsion and maintaining that emulsion at a temperature equal to or greater than the gelation point of the agarose, passing it through a static mixer to create agarose droplets and solidifying the agarose droplets in a second bath of hydrophobic liquid. The beads can then be washed and used or further processed to crosslink the agarose and/or add various functionalities on to the agarose. Another method for solidifying the agarose droplets is by using a heat exchanger to cool the stream continuously after it exits the static mixer. A similar process is used for the “cored” beads except cores, preferably in bead form, are introduced to the agarose before it enters the first hydrophobic liquid so that the agarose forms a coating on the cores. A similar process with either agarose beads (made by this or another process) or cored agarose (made by this or another process) can be used to add multiple layers of agarose on to the existing beads. An apparatus for running the process is also disclosed. | 09-09-2010 |
20100223980 | Rapid integrity testing of porous materials - The invention relates to a rapid recirculation based integrity testing of porous material and to an apparatus and system for performing the same. | 09-09-2010 |
20100221844 | Caustic stable chromatography ligands - The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as, | 09-02-2010 |
20100206785 | Cart and installation for treating biological liquid - The cart comprises a lateral face by which it is adapted to be juxtaposed against another cart. It further comprises a first pump, a second pump disposed below said first pump and laterally offset relative thereto, and a tank adapted to receive a feed container provided to contain said biological liquid, said tank being disposed above said first pump and offset laterally relative thereto. | 08-19-2010 |
20100200507 | Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH. | 08-12-2010 |
20100196589 | Room temperature stable agarose solutions - Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain gel-inhibiting additives into an aqueous polysaccharide solution, the gel point is reduced or eliminated and the solution remains liquid at room temperature indefinitely. Additives that have been found to work include salts, such as lithium chloride and zinc chloride and bases, such as sodium hydroxide and lithium hydroxide. Mixtures of said salts and said bases can also be used with the same desired results. The composition of these solutions of the present idea can be further modified to include other additives, such as organic co-solvents or non-solvents, pH modifiers, surfactants or other polymers to customize the properties of the solution to improve the processability for the desired application and to form structures such as films, beads and coated porous substrates. | 08-05-2010 |
20100190963 | Stirred Tank Reactor And Method - Container for sample preparation or processing, such as biomass culturing or processing, and optionally sample purification. In certain embodiments, the reactor is a bioreactor that includes a stirred cell device that simulates a tangential flow filter to reduce or eliminate clogging that can be caused by the solids generated. In certain embodiments, the solids comprise a precipitate or floc or beads, such as one that includes a polymer that binds the biomolecule(s) of interest, and impurities. In its method aspects, embodiments disclosed herein include purification and isolation of biomolecules of interest derived from cell culture fluids. The methods include carrying out sample preparation or processing in a container, culturing a biomass; generating solids by precipitating or flocculating a biomolecule of interest from the cultured broth; preventing the solids from settling in the container by agitation; and purification, such as by eluting the biomolecule of interest and filtering the same. | 07-29-2010 |
20100187167 | Method For Providing A Circuit For Biological Liquid And Circuit Obtained - The method comprises the step of forming pipes ( | 07-29-2010 |
20100184613 | Proteome Epitope Tags and Methods of Use Thereof in Protein Modification Analysis - Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided. | 07-22-2010 |
20100175393 | Biomaterial Freezing - The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process. | 07-15-2010 |
20100174051 | Asymmertric porous adsorptive bead - The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead. | 07-08-2010 |
20100173335 | Fast Microbiological Analysis Device And Method - The device includes means for holding a support ( | 07-08-2010 |
20100173325 | Composition and Method for Analysis of Target Analytes - A method of detecting analytes includes providing a mixture containing analytes to be analyzed and microparticles coated with competitive inhibitors of the analytes. First antibodies are reacted with the analytes and the competitive inhibitors under competitive binding conditions. The first antibodies bound to the competitive inhibitors are measured using flow cytometry. | 07-08-2010 |
20100170835 | Water Purification System And Method - The invention concerns a hydraulic connector ( | 07-08-2010 |
20100170833 | POWERED CARTRIDGES AND OTHER DEVICES WITHIN HOUSINGS - The present invention describes a system and method for supplying electrical power to a device, such as a filter element, located within a housing. In one embodiment, a conductive coil is embedded into the housing base, and a second coil is embedded into the filter element. Current is then passed through the coil in the housing base. Through induction, a current is created in the second coil in the filter element, in much the same way as a transformer functions. This inductive field may interfere with the operation of the various electronic functions, such as communications, sensing or other activities. To overcome this issue, an energy storage component, such as a capacitor, is included in the filter electronics. In this way, the power generated by the inductive field can be stored, and used when the inductive field is no longer present. | 07-08-2010 |
20100163495 | System and method for filtration of liquids - The present invention relates to a system and a process of running the system that allows for the long term filtration of product without loss of filtration capability due to clogging or fouling. The system is a normal flow filtration system having one or more filter cartridges attached to an outlet of a housing in the system. The filter cartridge(s) are contained within a bowl and depend preferably vertically from the outlet. Liquid enters the bowl of the housing and contacts the outer surfaces of the one or more cartridges. Impurities are trapped on or in the surface of the filter and the filtered liquid flows through the filter and through the outlet. One or more parameters such as flow rate, transmembrane pressure drop and/or time are measured and when the desired parameter(s) are met, the filtration ceases. A backflushing occurs back through the filter cartridges so as to remove the trapped impurities on or in the filter surface. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the cartridge(s) can be used to provide a lateral washing of the filter surfaces. The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is the restarted. | 07-01-2010 |
20100159581 | Adsorbent Filter Media For Removal Of Biological Contaminants In Process Liquids - Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid. | 06-24-2010 |
20100159143 | Ultrafiltration membranes and methods of making and use of ultrafiltration membranes - An inherently hydrophobic polymer membrane substrate having its surface rendered hydrophilic with a hydroxyalkyl cellulose and having a throughput greater than about 1500 L/m | 06-24-2010 |
20100158759 | Device For The Transfer Of A Medium - The device for the transfer of a medium comprises a magazine ( | 06-24-2010 |
20100156002 | High-throughput asymmetric membrane - A microporous asymmetrical membrane formed of one or more layers wherein the “tight” side of the membrane has an “opened” face or otherwise highly-porous reticulated surface is described. The microporous asymmetrical membrane has high throughput and high flux, even when used for filtering viscous materials, such as serum or plasma. The membrane's surface can be formed by ablation or solvation, or in a two or more layered structure, through an appropriate selection of casting dopes. | 06-24-2010 |
20100155248 | Water Purification System And Method, And Module For The System - The invention relates to a method and a system for purifying water whereby:
| 06-24-2010 |
20100154569 | Device For The Transfer Of A Medium - The device for the transfer of a medium comprises a magazine having two main faces ( | 06-24-2010 |
20100151511 | Biological culture assembly - The invention relates to a resealable or a single use cell culture assembly for use in growing, storing and transporting, cell and tissue cultures. The assembly includes a support frame for receiving a base member insert having an upper surface, such as a microscope slide, and a well frame, preferably partitioned into a plurality of well compartments having sidewalls with upper and lower surfaces, upper and lower edges, and upper and lower well openings. The well frame is adapted to be operatively positioned on the upper surface of the base member, and includes a sealing means positioned on or within the lower edge of the well frame. The sealing means is adapted to operatively create a liquid-impermeable releasable seal or barrier when the lower surface of the well frame is positioned on the upper surface of the base member, such that the sealing means is releasably positioned on the upper surface of the base member for maintaining a liquid-impermeable barrier between well compartments. The assembly may include a cover or lid positioned over the upper opening of the well frame. When the assembly is in a closed position, the well frame can be secured to the support frame by a variety of closure means. | 06-17-2010 |
20100129900 | Layered Flask Cell Culture System - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein gas permeable membranes in combination with air spaces that will allow the free flow of gases between the cell culture compartments and the external environment. Furthermore an interconnecting passageway is provided between each compartment and between the cell culturing vessel and the external environment. The expandable vessel promotes the growth of large numbers of adherent or suspension cells by providing the volumes of nutrient medium and gaseous exchange. | 05-27-2010 |
20100084342 | Method of and device for packing a chromatography column - A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained. | 04-08-2010 |
20100075409 | Device for microbiological analysis - The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum ( | 03-25-2010 |
20100075408 | Device for microbiological analysis - The device for the microbiological analysis of a support ( | 03-25-2010 |
20100075368 | Media for recovery of microorganism in the presence of antibiotics - The present invention provides a media and a method of using such as media for the bioburden or sterility testing of antibiotics or environmental testing of antibiotic manufacturing areas. The medium contains one or more divalent or trivalent cation constituents, preferably of magnesium, calcium, aluminum and iron that allow for microorganism growth even in the presence of residual antibiotic. | 03-25-2010 |
20100072079 | Electrochemical method for detecting boron in water - The invention relates to a method for detecting the presence of boron in water comprising the production of a conductive buffer solution comprising water and at least one boron complexing agent, the introduction into an electrochemical cell of said solution in the presence of at least one work electrode ( | 03-25-2010 |
20100065498 | Novel Coated Membranes and Other Articles - The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane. | 03-18-2010 |
20100063261 | Affinity chromatography matrices and methods of making and using the same - The invention provides methods of coupling protein ligands to a solid support. The invention also provides affinity chromatography matrices and methods of using affinity chromatography matrices to purify a target molecule. | 03-11-2010 |
20100063256 | Novel immunoglobulin-binding proteins with improved specificity - The present invention relates to modified immunoglobulin-binding proteins, e.g., | 03-11-2010 |
20100025323 | Water purification system and method - The invention concerns a water purification system ( | 02-04-2010 |
20100015107 | Expression elements - The invention relates to genetic elements capable of improving the levels of expression of operably-linked transcription units. In particular, said genetic elements are derived from the 5′ untranslated regions of ribosomal protein genes and may comprise a CpG island. Also provided are vectors and host cells comprising said genetic elements and methods of use to obtain high levels of recombinant gene expression. | 01-21-2010 |
20100012666 | Container having vortex breaker and system - A disposable container for fluid having an inlet and an outlet is provided. The container has a vortex breaker having a solid surface adapted to initially direct fluid away from the outlet and then through the outlet positioned adjacent the container outlet. | 01-21-2010 |
20100012665 | Container having vortex breaker and fluid diverter and system - A disposable container for fluid is provided. The container has a vortex breaker positioned adjacent the container outlet and a fluid diverter positioned adjacent each inlet to the container. | 01-21-2010 |
20100009460 | Multifunctional vacuum manifold - A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers. | 01-14-2010 |
20100006204 | Wireless enabled bags and containers - The present invention provides a process for incorporating a wireless device into a plastic container as part of the steps of manufacturing the container. The plastic container can be a flexible plastic bag and are formed of one or more sheets, generally two or more sheets of plastic film or a rigid plastic container such as a tub or tote. The bags are formed by sealing together adjacent edge portions of each film layer. One embodiment of the present invention is to incorporate a wireless device between the edge portions of the film(s) before or during sealing so that the wireless device becomes permanently sealed into the film material but is isolated from both the bag interior and the outside environment. Another embodiment is to incorporate the wireless device onto or into a plastic component that is sealed to the container, such as a nipple or port, so that the wireless device becomes permanently sealed to the container but is isolated from both the container interior and the outside environment. | 01-14-2010 |
20090321338 | Chromatography apparatus - A chromatographic apparatus is provided comprising a housing, a fluid inlet to the housing, a fluid outlet from the housing, an optional vent and a chromatographic packed bed in the housing. The fluid inlet and fluid outlet and optional vent are provided with connectors that connect a fluid inlet and a fluid outlet on other such chromatographic apparatus. | 12-31-2009 |
20090311776 | Stirred tank bioreactor - The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports or access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment location is also guaranteed through the use of the molded port features. The molded plastic allows for greater flexibility in material selection to reduce or eliminate lipid or cholesterol binding. | 12-17-2009 |
20090255861 | Filtration device with a pressure-activated means for bypassing serial filter layers - A serial-flow filtration device is provided with pressure-activated means for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated means capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer. The bypass means can be embodied, for example, as a pressure-breachable seal or as a pressure-activated gate. | 10-15-2009 |
20090252948 | Method of manufacturing membranes and the resulting membranes - This invention provides a process for making microporous membranes from a polymer solution and the membranes therefrom. A thermal assist, such as heating of the polymer solution can be effected subsequent to shaping the solution, such as by forming a film, tube or hollow fiber of the solution under conditions that do not cause phase separation. In a preferred embodiment, the formed solution is briefly heated to generate a temperature gradient through the body of the formed solution. The polymer in solution then is precipitated to form a microporous structure. The formation of a wide variety of symmetric and asymmetric structures can be obtained using this process. Higher temperatures and/or longer heating times effected during the heating step result in larger pore sizes and different pore gradients in the final membrane product. | 10-08-2009 |
20090246885 | Media for affinity chromatography - The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same. | 10-01-2009 |
20090220294 | Connector for flexible tubing - A connector is provided for connecting a flexible conduit with a second conduit having a barbed outer surface. The connector accommodates the end of the flexible conduit and the end of the second conduit in a manner which prevents removal of the flexible conduit and the second conduit from the connector. Optionally, the connector has a ring that may be used to apply additional pressure and security to the outer surface of the flexible conduit. additionally, the connector may have a wireless enabled communication and optionally, memory device such as a RFID tag attached or affixed to it. | 09-03-2009 |
20090211061 | Tie wrap connector - A tie wrap connector is formed of a strap, a locking head and an insert positioned adjacent said locking head. The insert has an arc shaped surface positioned remote from the locking head. The strap is positioned around a device to be secured to the locking head. The insert is adjacent the locking head and the device to be secured and is drawn against the outer surface of the device to be secured by the strap as it is secured to the locking head. | 08-27-2009 |
20090200226 | Multifiltration cartridge filtration apparatus - A filtration apparatus is provided comprising a housing having an inlet and an outlet and a plurality of spirally wound filtration cartridges. The filtration cartridges include two filter layers, a feed spacer layer and a permeate spacer layer. Seals are provided to prevent admixtures of feed and permeate and to permit recovery of permeate. | 08-13-2009 |
20090181426 | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants - The invention relates to cell culture methods, kits and cell lines for producing recombinant products, e.g. therapeutic proteins and antibodies, in the presence of reduced levels of one or more contaminants and further to methods of purifying those products. | 07-16-2009 |
20090142805 | High expression cell line that eliminates gene amplification - The present invention relates to methods, cell lines and kits for producing high titers of recombinant proteins without the need for gene amplification. | 06-04-2009 |
20090081698 | High throughput cell-based assays, methods of use and kits - In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the plate is placed into a carrier pate having open wells in register with the wells of the filter plate or one may use a wicking device or an underdrain attached to the bottom of the filter plate. Sufficient wash liquid is added to allow for filtration by the effect of gravity to occur. Cells are retained within the wells at a rate of 4 times that of other rapid methods. | 03-26-2009 |
20090078634 | Chromatography columns - The present invention relates to a chromatography column that removes the longitudinal load from the column tube altogether and transfers it to a yoke and stanchion arrangement situated around but external to the column tube. By using the yoke/stanchion system, the central adjuster can be used to move the top end into and out of the housing. Thus, when internal pressure is applied to the column, the tube experiences no longitudinal load. Additionally, the yoke and stanchion design allows for complete removal of the end from the tube without cumbersome disassembly. Moreover, the yoke provides a place to retain the end while the tube is being filled, emptied, cleaned or repaired. | 03-26-2009 |
20080310768 | Disposable processing bag with alignment feature
- The present invention is an alignment device for a bag containing one or more ports wherein the alignment device is attached to either the one or more ports such as by wire ties, clamps or cable ties or to the bag adjacent the one or more ports via adhesives or welding or molding such as overmolding. The plate has either an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a bag holder such as a carboy or tote to ensure proper alignment of the bag and its port(s) in the holder. In one embodiment the plate formed of plastic, metal, wood or composite material has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) are extended through the holes of the plate and the plate is attached to the bag by retainers on the port(s) below the plate. Such retainers can be plastic cable ties, wire ties, tube clamps and the like. Alternatively, the plate may be fitted over the port(s) and attached to the bag such as by thermal bonding or welding or overmolded to the bag or the bag is formed and molded to the plate. The plate may have any unique design that ensures that the alignment of the bag in the holder is correct and cannot be reversed or incorrectly aligned. Such designs use a plate that is affixed to the bag or its port(s) in such a way that it cannot be realigned or moved out of register. Such designs include but are not limited to graphic indicators and unique shapes. | 12-18-2008 |
20080284163 | Connector for flexible tubing - A connector is provided for connecting a flexible conduit with a second conduit having a barbed outer surface. The connector accommodates the end of the flexible conduit and the end of the second conduit in a manner which prevents removal of the flexible conduit and the second conduit from the connector. Optionally, the connector has a ring that may be used to apply additional pressure and security to the outer surface of the flexible conduit. additionally, the connector may have a wireless enabled communication and optionally, memory device such as a RFID tag attached or affixed to it. | 11-20-2008 |
20080257814 | Filtration Cartridge - A filtration cartridge is provided comprising one or a stack of filtration units sealed to each other at their inner periphery and their outer periphery and to end caps thereby eliminating the need for a housing surrounding the stack. Fluid pathways are provided so that filtration of all incoming feed is assured prior to passing from the cartridge as filtrate. | 10-23-2008 |
20080257813 | Cassette-style filtration apparatus - A filtration apparatus is provided wherein a filtration membrane is positioned by gaskets on feed plates and filtrate plates rather than being bonded thereto. | 10-23-2008 |
20080245736 | Crosslinked cellulosic nanofiltration membranes - The present invention relates to a nanofilter formed by using a porous ultrafiltration membrane as a precursor, and carefully controlling reaction conditions so as to maintain sufficient hydrophilic nature of the membrane while causing the pore structure to close to a nanofilter range (less than 400 Daltons). This produces a solvent stable cellulose nanofiltration membrane capable of operating at satisfactory flux in aqueous solutions, and being low binding to organic biomaterials. | 10-09-2008 |
20080213135 | Wireless enabled device - The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry. | 09-04-2008 |
20080207465 | Assay systems with adjustable fluid communication - Systems, including apparatus and methods, for performing assays with adjustable fluid communication between samples. | 08-28-2008 |