MICROMASS UK LIMITED Patent applications |
Patent application number | Title | Published |
20150294850 | Ion Trap With Spatially Extended Ion Trapping Region - A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction. | 10-15-2015 |
20150155149 | Cryogenic Collisional Cooling Cell - A mass spectrometer is disclosed comprising a cooling cell | 06-04-2015 |
20150144781 | METHOD AND APPARATUS FOR CONTROLLING THE SUPPLY OF IONS - A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow. | 05-28-2015 |
20150120212 | METHOD FOR THE INVESTIGATION OF DIFFERENCES IN ANALYTICAL DATA AND AN APPARATUS ADAPTED TO PERFORM SUCH A METHOD - A method of investigating differences in data produced by at least one analytical instrument comprising providing a first data set from a first sample in a plurality of data bins; providing a second data set from a second sample in a plurality of data bins; providing a data model of said data sets in which the data in a plurality of data bins from the first data set is linked to the data in the corresponding bins of the second data set, each linked pair having an associated switch parameter linking the two together; and, exploring the posterior probability distribution for the data model as a function of the switch parameters to produce a posterior probability distribution map. | 04-30-2015 |
20150090873 | Method of Single Point Internal Lock-Mobility Correction - A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. | 04-02-2015 |
20150076341 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 03-19-2015 |
20150076338 | MASS SPECTROMETER, CONTROL SYSTEM AND METHODS OF OPERATING AND ASSEMBLING A MASS SPECTROMETER - A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network. The mass spectrometer can also include a scheduler operable to introduce discrete packets of instructions to the network at predetermined times to instruct at least one module to perform a predetermined operation. | 03-19-2015 |
20150041636 | Multi-Dimensional Survey Scans For Improved Data Dependent Acquisitions - A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property (e.g. ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. mass to charge ratio). A plurality of parent ions of interest are then determined from the initial multi-dimensional survey scan. Once parent ions of interest have been determined, the plurality of parent ions of interest are sequentially selected based upon the first and second physico-chemical properties during a single cycle of separation. The parent ions of interest may then be fragmented and corresponding fragment ions may then be mass analysed. | 02-12-2015 |
20150034814 | MALDI Imaging and Ion Source - An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror. | 02-05-2015 |
20150034813 | Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis - A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react. | 02-05-2015 |
20150021469 | Interfacing Capillary Electrophoresis to a Mass Spectrometer via an Impactor Spray Ionization Source - A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions. | 01-22-2015 |
20140361162 | IMAGING MASS SPECTROMETER AND A METHOD OF MASS SPECTROMETRY - An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process. | 12-11-2014 |
20140326867 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 11-06-2014 |
20140326865 | Diathermy Knife Ionisation Source - A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife. An electric current is applied to the diathermy knife such that the diathermy knife vaporises a portion of the substrate. The vapour is aspirated via a sampling tube pumped by a venturi pump into a vacuum chamber of a mass spectrometer. Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionised to form analyte ions which are then mass analysed. | 11-06-2014 |
20140312222 | Ion Mobility Separation Device With Moving Exit Aperture - A method and device for separating ions according to their ion mobility are disclosed. An ion guide is provided having a plurality of electrodes arranged to form an ion guiding path that extends in a closed loop. RF voltages are supplied to at least some of the electrodes in order to confine ions within said ion guiding path. A DC voltage gradient is maintained along at least a portion of a longitudinal axis of said ion guide, wherein the voltage gradient urges ions along the ion guide such that the ions separate according to their ion mobility as the ions pass along the ion guide. As time progresses the portion of the ion guide along which the DC voltage gradient is maintained is moved along the ion guide. An ion exit region is provided which moves around said ion guide such that ions exit said ion guide at different locations at different times. The present invention allows ions to exit the ion guide after the ions have been separated and without having to wait until the ions reach a fixed exit point, by which time the ions may re-merge with other ions | 10-23-2014 |
20140306103 | Ion Inlet For A Mass Spectrometer - An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets. | 10-16-2014 |
20140299761 | Ion Trap With Spatially Extended Ion Trapping Region - A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction. | 10-09-2014 |
20140291501 | Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer - A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser. | 10-02-2014 |
20140264008 | Mass Spectrometer - A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. Transient DC voltages are applied to the electrodes in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser. | 09-18-2014 |
20140252223 | Tandem Ion Trapping Arrangement - A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment, ions are simultaneously scanned from both the first and second ion trap. At any instant in time, the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded. | 09-11-2014 |
20140246580 | Mass Analysis Using Alternating Fragmentation Modes - A method of mass spectrometry is disclosed wherein a Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation mode and a low fragmentation mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples. | 09-04-2014 |
20140246576 | Method and Apparatus for Generating Spectral Data - A method of generating spectral data comprising the steps of deriving a temporally separated sample from a temporal separation device and subjecting the temporally separated sample to an analysis involving scanning at least one spectrally significant parameter, wherein the analysis is performed so that at least two scans in succession are in opposite directions | 09-04-2014 |
20140246575 | Segmented Planar Calibration for Correction of Errors in Time of Flight Mass Spectrometers - An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions. The ion detector system generates separate first mass spectral data sets for each detector element and then applies a calibration coefficient to each of the first mass spectral data sets to produce a plurality of second calibrated mass spectral data sets. The plurality of second calibrated mass spectral data sets are then combined to form a composite mass spectral data set. | 09-04-2014 |
20140231642 | Mass Spectrometer With Bypass of a Fragmentation Device - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 08-21-2014 |
20140217279 | Aperture Gas Flow Restriction - A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture. The effective area of the opening between the two vacuum chambers may be varied by rotating a disk having an aperture in front of the differential pumping aperture so as to vary the gas flow rate through the opening and between the two chambers. | 08-07-2014 |
20140197308 | Function Switching With Fast Asynchronous Acquisition - A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions. | 07-17-2014 |
20140191123 | Ion Guide Coupled to MALDI Ion Source - A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other. | 07-10-2014 |
20140166895 | Ion Tunnel Ion Guide - An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments. | 06-19-2014 |
20140166877 | Method of Processing Mass Spectral Data - A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T | 06-19-2014 |
20140163899 | System of Estimating the Cross-Sectional Area of a Molecule for Use in the Prediction of Ion Mobility - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 06-12-2014 |
20140158879 | Method And System Of Identifying A Sample By Analysing A Mass Spectrum By The Use Of A Bayesian Inference Technique - A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by Bayesian inference to produce a family of plausible deconvoluted data sets, inferring an underlying deconvoluted data set from the family of plausible deconvoluted data sets and using the underlying deconvoluted data set to identify and/or characterise the sample. | 06-12-2014 |
20140158878 | Mass Spectrometer - A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes. A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide. | 06-12-2014 |
20140151547 | Atmospheric Pressure Ion Source By Interacting High Velocity Spray With A Target - An ion source is disclosed comprising a nebuliser | 06-05-2014 |
20140145074 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to their mass to charge ratio by pulsing an applied axial electric field ON and OFF. | 05-29-2014 |
20140138534 | Mass Spectrometer Device and Method Using Scanned Phase Applied Potentials in Ion Guidance - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 05-22-2014 |
20140131568 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the on trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap. | 05-15-2014 |
20140131566 | Mass Spectrometer - A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes. | 05-15-2014 |
20140131565 | Ion Guiding Device - An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively large cross-sectional profile to an ion guide which has a relatively small cross-sectional profile in order to improve the subsequent ion confinement of the ions. | 05-15-2014 |
20140124663 | Ion Mobility Separator With Variable Effective Length - An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator. | 05-08-2014 |
20140117219 | Dynamic Resolution Correction of Quadrupole Mass Analyser - A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition. | 05-01-2014 |
20140110576 | Method of Charge Reduction of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine. | 04-24-2014 |
20140099725 | METHODS FOR THE ANALYSIS OF GLYCOPROTEINS OR GLYCOPEPTIDES BY MASS SPECTROMETRY - A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing said chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptide ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction data mass spectral data to provide structural information relating to the glycopeptide. | 04-10-2014 |
20140054454 | Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers - A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector. | 02-27-2014 |
20140051181 | Glow Discharge Ion Source - A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions. | 02-20-2014 |
20140051092 | Method And Apparatus For The Analysis Of Biological Samples - A method for the detection and quantitation of analytes of interest and variants of the analyte of interest comprising the steps of:
| 02-20-2014 |
20140048704 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. | 02-20-2014 |
20140048702 | Ion Guide With Orthogonal Sampling - A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar. | 02-20-2014 |
20140048701 | Pre-Scan For Mass to Charge Ratio Range - A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters. | 02-20-2014 |
20140048696 | DC Ion Guide for Analytical Filtering/Separation - An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction. | 02-20-2014 |
20140048695 | Curved Ion Guide With Non Mass To Charge Ratio Dependent Confinement - A non-linear ion guide is disclosed comprising a plurality of electrodes. An ion guiding region is arranged between the electrodes, and the ion guiding region curves at least in a first direction. A DC voltage is applied to at least some of the electrodes in order to form a DC potential well which acts to confine ions within the ion guiding region in the first direction. | 02-20-2014 |
20140042314 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 02-13-2014 |
20140042312 | M/Z Targeted Attenuation on Time of Flight Instruments - A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity. | 02-13-2014 |
20140027627 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section and a second ion guide section. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. Electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section. | 01-30-2014 |
20140014830 | Space Focus Time of Flight Mass Spectrometer - A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector. | 01-16-2014 |
20140005970 | Method Of Deadtime Correction in Mass Spectrometry | 01-02-2014 |
20140005954 | Method Of Processing Multidimensional Mass Spectrometry | 01-02-2014 |
20130334413 | Fast Pushing Time of Flight Mass Spectrometer Combined With Restricted Mass to Charge Ratio Range Delivery - Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T | 12-19-2013 |
20130317756 | Method Of Deadtime Correction In Mass Spectrometry - A method of improving the fidelity of m/z dependent measurements for a species of interest in an analyte in a mass spectrometer, which method comprises the steps of acquiring raw data produced in a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent measurements with associated uncertainties. | 11-28-2013 |
20130306858 | Asymmetric Field Ion Mobility in a Linear Geometry Ion Trap - A linear ion trap is disclosed wherein an asymmetric voltage waveform is applied to electrodes forming the ion trap which causes ions to become radially separated according to their differential ion mobility. An axial potential barrier is arranged at the exit of the ion trap such that ions having a first differential ion mobility and a first radial displacement are retained axially within the ion trap but ions having a second differential ion mobility and a second radial displacement are ejected axially from the ion trap. | 11-21-2013 |
20130256524 | Mass Spectrometer With Beam Expander - A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser. | 10-03-2013 |
20130252342 | Detection And Quantification Of Vitamin D Metabolites Using An Alkylamine To Form Stable Adducts For Mass Spectrometric Analysis - The invention describes a method of determining the amount of an analyte in a sample wherein the analyte comprises one or more vitamin D metabolites; comprising the steps of; contacting the analyte with an alkylamine to form an alkylamine adduct; subjecting the adduct to a MS technique to determine the amount of the adduct; and calculating the amount of the analyte equivalent to the amount of the adduct. | 09-26-2013 |
20130248704 | Mass Spectrometer Arranged to Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 09-26-2013 |
20130234016 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF. | 09-12-2013 |
20130221242 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap. | 08-29-2013 |
20130218478 | Method And System Of Identifying A Sample By Analysing A Mass Spectrum By The Use Of A Bayesian Inference Technique - A method of and apparatus for identifying and/or characterising a sample that may incorporate two or more isomeric or isobaric compounds such as hydroxylated metabolites. The method involves modelling an ensemble of possible structures for each of two or more known isomeric or isobaric compounds, calculating a theoretical collision cross-section for each modelled structure, averaging the calculated values for each known compound to provide a theoretical collision cross-section value for each known compound. A travelling wave ion mobility cell is used to measuring a collision cross-section value for the sample compound and the measured value is then compared with the theoretical values to identify which of the two or more known compounds the sample compound most closely resembles. | 08-22-2013 |
20130214149 | Ion Guiding Device - An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively large cross-sectional profile to an ion guide which has a relatively small cross-sectional profile in order to improve the subsequent ion confinement of the ions. | 08-22-2013 |
20130207767 | Planar Transformers - A planar transformer comprises a plurality of conductive windings provided by at least one PCB and linked by a common ferrite core passing through the or each PCB. The transformer windings are at least partially magnetically shielded from the ferrite core by a conductive non-continuous shield formed by copper planed areas on one or more of the PCB layers to improve the coupling between the windings. | 08-15-2013 |
20130206974 | Mass Spectrometer Incorporating Hydrogen-Deuterium Exchange - A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange. | 08-15-2013 |
20130200260 | Capacitor Assembly For A Mass Spectrometer - A capacitor assembly ( | 08-08-2013 |
20130200258 | Method And System Of Identifying A Sample By Analyising A Mass Spectrum By The Use Of A Bayesian Inference Technique - A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured spectrum of data from a sample using a mass spectrometer, deconvoluting the measured spectrum of data by Bayesian inference to produce a family of plausible deconvoluted spectra of data, inferring an underlying spectrum of data from the family of plausible deconvoluted spectra of data and using the underlying spectrum of data to identify and/or characterise the sample. | 08-08-2013 |
20130175439 | Mass Spectrometer - A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. Transient DC voltages are applied to the electrodes in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser. | 07-11-2013 |
20130168546 | Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution - A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum. | 07-04-2013 |
20130146762 | Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave. | 06-13-2013 |
20130140469 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section and a second ion guide section. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. Electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section. | 06-06-2013 |
20130138421 | Automatic Human Language Translation - A computer device for performing automatic human language translation includes memory storing program code of an application program and program code of a translation utility. A processor executes program code of the application program configured to display localized text in a first language on a display screen of the computer device. The processor further executes program code of the translation utility configured to detect user interest in the localized text, to acquire the localized text from the display screen in automatic response to detecting the user interest in the localized text, to obtain one or more translations in a second language for the localized text in automatic response to acquiring the localized text from the screen, and to report each obtained translation for the localized text. | 05-30-2013 |
20130122599 | Fragmentation Reagents For Mass Spectrometry - A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol. | 05-16-2013 |
20130119247 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 05-16-2013 |
20130112865 | Method of Avoiding Space Charge Saturation Effects In An Ion Trap - A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects. | 05-09-2013 |
20130099110 | Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto - An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order. | 04-25-2013 |
20130056629 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. | 03-07-2013 |
20130026358 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 01-31-2013 |
20120326019 | Method Of Mass Spectrometry - This invention comprises a method of imaging of a substrate in which a sample of interest is first ionized at multiple known positions whereafter a mass spectrum of the ionized sample at each of the multiple known positions is produced using a Mass Spectrometer. An overall spectrum for the whole sample is then created, and a number of peaks within the overall spectrum is selected. A scan distribution for at least some of the selected peaks is created, and the scan distributions are compared to identify correlations between different analytes within the sample. | 12-27-2012 |
20120292500 | MASS SPECTROMETER SAMPLING CONE WITH COATING - A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. | 11-22-2012 |
20120286152 | ION SOURCE WITH SURFACE COATING - A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. | 11-15-2012 |
20120280123 | Ion Tunnel Ion Guide - An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments. | 11-08-2012 |
20120267526 | Mass Spectrometer - An ion trap mass analyser is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyser by a radial pseudo-potential well. The ions are also confined axially within a quadratic axial potential well. An AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser in order to excite parametrically ions within the ion trap. | 10-25-2012 |
20120208289 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained. | 08-16-2012 |
20120199734 | Mass Spectrometer - An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyser. | 08-09-2012 |
20120136586 | Acquisition Method and Apparatus for Mass Spectrometer Data - A method and apparatus for acquiring data from a mass spectrometer and its transmission to a computer system including a data acquisition engine, a network interface and a throughput optimization module which includes a ring buffer and a protocol stack. A compression engine may be provided between the acquisition engine and the ring buffer. The ring buffer is configured as a number of segments containing portions of memory matching the size of data words from the acquisition engine. When a segment is full of data corresponding to the words, or is partially full and has received data containing an end of scan marker, the number of words in the segment is written into a header word in the segment and the data in that segment are moved to the protocol stack. Subsequent data is received by the next segment in the buffer. | 05-31-2012 |
20120130700 | METHOD AND SYSTEM OF ESTIMATING THE CROSS-SECTIONAL AREA OF A MOLECULE FOR USE IN THE PREDICTION OF ION MOBILITY - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 05-24-2012 |
20120126110 | Method of Processing Mass Spectral Data - A method of processing mass spectral data is disclosed comprising digitizing a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T | 05-24-2012 |
20120126108 | Dual Source Mass Spectrometry System - A dual source mass spectrometer system ( | 05-24-2012 |
20120122077 | Method to Detect and Sequence Post Translationally Modified Peptides - A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed. | 05-17-2012 |
20120119078 | Ion Population Control Device For A Mass Spectrometer - A mass spectrometer is disclosed wherein an ion beam attenuator is arranged upstream of an ion trap mass analyser. An ion tunnel ion trap comprising an upstream ion accumulation section and a downstream ion accumulation section is arranged upstream of the ion beam attenuator. Ions are released from the ion tunnel ion trap and the intensity of the ion beam which is transmitted to the ion trap analyser is controlled by the ion beam attenuator. The fill time during which ions are admitted into the ion trap mass analyser remains substantially constant and is substantially independent of the intensity of the ion beam. | 05-17-2012 |
20120116690 | METHOD AND SYSTEM OF ESTIMATING THE CROSS-SECTIONAL AREA OF A MOLECULE FOR USE IN THE PREDICTION OF ION MOBILITY - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 05-10-2012 |
20120112055 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 05-10-2012 |
20120104246 | Dual Source Mass Spectrometry System - In or for a dual source mass spectrometer system ( | 05-03-2012 |
20120097844 | Dual Source Mass Spectrometry System - In or for a dual source mass spectrometry system ( | 04-26-2012 |
20120085901 | Time Of Flight Acquisition System - A Time of Flight Acquisition system is disclosed wherein a digitiser ( | 04-12-2012 |
20120056084 | Apparatus Comprising an Ion Mobility Spectrometer - A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber. | 03-08-2012 |
20120032074 | Mass Spectrometer Arranged To Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 02-09-2012 |
20120018631 | ION-MOBILITY ANALYSER - An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes | 01-26-2012 |
20110303838 | Method Of Avoiding Space Charge Saturation Effects In An Ion Trap - A mass spectrometer is provided comprising a first ion trap ( | 12-15-2011 |
20110291001 | Ion Mobility Spectrometer - An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer ( | 12-01-2011 |
20110284734 | Ion Mobility Spectrometer - An ion mobility spectrometer ( | 11-24-2011 |
20110266435 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section ( | 11-03-2011 |
20110233396 | Mass Spectrometer - A mass analyser | 09-29-2011 |
20110215237 | Mass Analysis Using Alternating Fragmentation Modes - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device. | 09-08-2011 |
20110210242 | Ion Source with Device for Oxidising a Sample - An ion source is disclosed wherein a sample is introduced into the sample chamber ( | 09-01-2011 |
20110189788 | Glow Discharge Ion Source - A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode ( | 08-04-2011 |
20110180706 | Atmospheric Pressure Solids Analysis Probe Assembly - An atmospheric pressure ion source probe assembly ( | 07-28-2011 |
20110180704 | Mass Spectrometer - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 07-28-2011 |
20110168882 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide ( | 07-14-2011 |
20110127416 | Mass Spectrometer - A mass spectrometer is disclosed comprising a sampling cone ( | 06-02-2011 |
20110114835 | Method Of Charge Reduction Of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell | 05-19-2011 |
20110095176 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 04-28-2011 |
20110095175 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes ( | 04-28-2011 |
20110062323 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 03-17-2011 |
20110057097 | Mass Spectrometer - A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods | 03-10-2011 |
20110049358 | Linear Ion Trap - A linear ion trap ( | 03-03-2011 |
20110049357 | ION GUIDING DEVICE - An ion guiding device is disclosed comprising a first ion guide ( | 03-03-2011 |
20110049353 | Mass Spectrometer - A mass spectrometer is disclosed wherein a signal output from an ion detector is digitised using an Analogue to Digital Converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise. | 03-03-2011 |
20110042565 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator | 02-24-2011 |
20110042563 | Mass Spectrometer | 02-24-2011 |
20110024618 | Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave. | 02-03-2011 |
20110024616 | Gas Electron Multiplier Detector - A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM | 02-03-2011 |
20100327157 | Mass Spectrometer - A mass spectrometer is disclosed comprising a time of flight mass analyser ( | 12-30-2010 |
20100301952 | Method For The Production Of High Amplitude RF Voltages With Control Of The Phase Angle Between Outputs - A method of producing high frequency high amplitude AC voltages with control of the phase angle between outputs from a plurality of generators having individual DC current controlled variable inductors which method comprises controlling the timing of the circuit to allow inputs at the same frequency to have their phase angle preserved. All the outputs are phase locked and synchronised to a common external timed signal and programmed to the same output frequency. | 12-02-2010 |
20100301208 | Mass Spectrometer - A fault detection system for protecting a mass spectrometer from the effects of temperature extremes. The system comprises an ion block, a thermal source for providing thermal energy to the ion source block, a temperature sensor providing a reading for the temperature of the ion source block, a temperature regulation means for controlling the thermal source in dependence of the reading and a control system for monitoring the temperature change produced by the energy source. | 12-02-2010 |
20100301207 | Mass Spectrometer - A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use. A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing. | 12-02-2010 |
20100301206 | Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes ( | 12-02-2010 |
20100301201 | Mass Spectrometer And Method Of Mass Spectrometry - The invention relates to a method of derivina improved data from a mass spectrometer. The method includes operating the mass spectrometer in a mode enabling quantitation; assigning a threshold value for the total ion current (TIC) above which at least MS and/or MSMS data is desired; and triggering the mass spectrometer out of the mode enabling quantitation into at least an MS and/or MSMS mode when said TIC rises above the threshold but triggering only at such time at or after a confirmed TIC maxima has been reached. | 12-02-2010 |
20100301200 | Mass Spectrometer - An ion source, a mass spectrometer and a method of enhancing the performance of an ion source for use with a mass spectrometer. The ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber. A fluid flow passageway is provided between the ion source enclosure and the outer cover. The method of the invention comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60° c. and 80° c. and preferably at 70° c. | 12-02-2010 |
20100294923 | MASS SPECTROMETER - A collision or fragmentation cell ( | 11-25-2010 |
20100252730 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap ( | 10-07-2010 |
20100237237 | TANDEM ION TRAPPING ARRANGEMENT - A mass spectrometer is disclosed comprising a first storage ion trap ( | 09-23-2010 |
20100213361 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 08-26-2010 |
20100171055 | Liquid-Chromatography Apparatus Having Diffusion-Bonded Titanium Components - An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates. | 07-08-2010 |
20100148056 | Mass Spectrometer - A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap ( | 06-17-2010 |
20100108879 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer ( | 05-06-2010 |
20100108878 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter ( | 05-06-2010 |
20100096543 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed wherein the time period between successive orthogonal acceleration pulses is less than the time of flight of ions having the maximum mass to charge ratio of interest. As a result, some ions are subject to wrap-around and will appear in a subsequent mass spectrum. Mass spectra obtained at two different sampling rates may be compared and mass peaks relating to ions which have and have not been subject to wrap-around may be identified. | 04-22-2010 |
20100084547 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals ( | 04-08-2010 |
20100072360 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell ( | 03-25-2010 |
20100065737 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser ( | 03-18-2010 |
20100065733 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator ( | 03-18-2010 |
20100044561 | APPARATUS COMPRISING AN ION MOBILITY SPECTROMETER - A mass spectrometer is disclosed comprising a first chamber ( | 02-25-2010 |
20100038530 | Mass Spectrometer - An ion guide or ion trap ( | 02-18-2010 |
20100032561 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device ( | 02-11-2010 |
20100001180 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined. | 01-07-2010 |
20090321628 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T | 12-31-2009 |
20090314935 | Mass Spectrometer - A mass analyser ( | 12-24-2009 |
20090314934 | MASS SPECTROMETER - A multi-turn Time of Plight mass analyser is disclosed comprising a first electric sector ( | 12-24-2009 |
20090302210 | MASS SPECTROMETER - A mass spectrometer comprising a collision, fragmentation or reaction cell ( | 12-10-2009 |
20090302209 | MASS SPECTROMETER - An ion guide or mass analyser ( | 12-10-2009 |
20090294642 | Mass Spectrometer - A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser ( | 12-03-2009 |
20090272891 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor ( | 11-05-2009 |
20090242749 | MASS SPECTROMETER - An Electrospray ionisation ion source is disclosed comprising a capillary tube ( | 10-01-2009 |
20090218487 | MASS-SPECTROMETER INTERFACE HOUSING - An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed. | 09-03-2009 |
20090194688 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device ( | 08-06-2009 |
20090173880 | Mass Spectrometer - An ion guide ( | 07-09-2009 |
20090173877 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first ion trap or ion guide ( | 07-09-2009 |
20090166525 | Mass Spectrometer - A method of chemical separation includes dispensing a sample from a sample pumping system, pumping a solvent from a solvent gradient pumping system to elute the dispensed sample through a separation column, identifying an analyte of interest in the eluting sample, and pumping a solvent from the sample pumping system for peak parking of the analyte in the separation column. | 07-02-2009 |
20090134321 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap ( | 05-28-2009 |
20090121123 | Mass Spectrometer - An ion guide or ion trap ( | 05-14-2009 |
20090114810 | MASS SPECTROMETER - An ion trap mass analyser ( | 05-07-2009 |
20090114808 | Mass spectrometer - A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output. | 05-07-2009 |
20090072136 | Mass Spectrometer - A mass analyser ( | 03-19-2009 |
20090057547 | MASS SPECTROMETER - A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Q | 03-05-2009 |
20090057546 | MASS SPECTROMETER | 03-05-2009 |
20090039245 | Mass Spectrometer - A Matrix Assisted Laser Desorption Ionisation ion source or ion imaging device is disclosed comprising a laser ( | 02-12-2009 |
20090014641 | Mass Spectrometer - A closed-loop ion guide ( | 01-15-2009 |
20090014639 | Mass Spectrometer - A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source ( | 01-15-2009 |
20090014637 | Mass Spectrometer - An ion guide or ion trap | 01-15-2009 |
20080318213 | Mass Spectrometer - A mass spectrometer and a method of spectrometry are disclosed wherein liquid chromatography mass spectral data are probabilistically clustered on the basis of mass to charge ratio and retention time. | 12-25-2008 |
20080302958 | Mass Spectrometer - An ion trap mass analyser ( | 12-11-2008 |
20080286764 | Method of mass spectrometry - A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample. | 11-20-2008 |
20080265152 | Mass Spectrometer - A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system ( | 10-30-2008 |