Microbial Chemistry Research Foundation Patent applications |
Patent application number | Title | Published |
20150140018 | ANTI-CXADR ANTIBODY - An object is to find a target molecule effective for cancer treatments and the like and to provide an antibody capable of specifically binding to the molecule, an anticancer agent comprising the antibody as an active ingredient, and so forth. Hence, prostate cancer cell lines (LNCaP-CR cells and LNCaP cells) were compared by SST-REX, and CXADR was identified as a molecule involved in tumor formation and so on. Then, a monoclonal antibody against CXADR was prepared, and the anti-cancer activity, ADCC activity, CDC activity, and so forth were examined. The result revealed that an antibody capable of binding to an epitope present at positions 181 to 230 of a CXADR protein derived from human exhibited an anti-cancer activity against prostate cancer cells, pancreatic cancer cells, and colorectal cancer cells. Further, it was also revealed that the antibody had an ADCC activity and a CDC activity. Moreover, the structures of light chain and heavy chain variable regions of the antibody were successfully determined. | 05-21-2015 |
20140256923 | Novel Compound, Method for Producing Same, and Use of Same - A compound represented by the following Structural Formula (A) or a salt thereof. The compound or the salt thereof is suitably produced from a microorganism belonging to the genus | 09-11-2014 |
20140046087 | Compound, Method for Producing the Same, and Method for Producing Oseltamivir Phosphate - A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound represented by the following general formula (2), a compound represented by the following general formula (3), and a compound represented by the following general formula (4): | 02-13-2014 |
20130345411 | NOVEL AMINOGLYCOSIDE ANTIBIOTICS - This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them. | 12-26-2013 |
20130338375 | Thioamide Compound, Method for Producing Thioamide Compound, Method for Producing [(4R,6R)-6-Aminoethyl-1,3-Dioxan-4-YL]Acetate Derivative, and Method for Producing Atorvastatin - A thioamide compound represented by the following general formula (1); | 12-19-2013 |
20130337050 | Drug Transporter Permeating Blood-Brain Barrier, Peptide and Use Thereof - A peptide, wherein the peptide comprises an amino acid sequence expressed by the following SEQ ID NO: 1, an amino acid sequence expressed by the following SEQ ID NO: 2, an amino acid sequence expressed by the following SEQ ID NO: 3, an amino acid sequence expressed by the following SEQ ID NO: 4, or any combination thereof: | 12-19-2013 |
20130196415 | MICROORGANISM BELONGING TO GENUS BACILLUS, THROMBOLYTIC ENZYME, AND METHOD FOR TREATING WASTE - A microorganism belonging to the genus | 08-01-2013 |
20120190746 | AFLATOXIN PRODUCTION INHIBITOR AND METHOD FOR CONTROLLING AFLATOXIN CONTAMINATION USING THE SAME - The present invention relates to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor, specifically relating to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: | 07-26-2012 |
20120003717 | STREPTOMYCES STRAIN THAT DECOMPOSES PROTEINS RECALCITRANT TO PROTEOLYSIS - The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to | 01-05-2012 |
20110213164 | NOVEL COMPOUND CERAMIDASTIN, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME - A compound having a structure expressed by the following Structural Formula (1): | 09-01-2011 |
20100179324 | ANTI-TUMOR AGENT COMPRISING SULPHOSTIN OR SULPHOSTIN-RELATED COMPOUND AS THE ACTIVE INGREDIENT - An anti-tumor agent containing, as an active ingredient, at least one of a sulphostin-related compound represented by the following General Formula (I), a pharmacologically acceptable salt thereof and a hydrate thereof; and a pharmaceutical composition containing the anti-tumor agent: | 07-15-2010 |
20080312080 | Novel dioctatin derivatives and production process thereof - To provide dioctatin derivatives, a production process thereof, an aflatoxin production inhibitor containing the dioctatin derivative, and a method of controlling aflatoxin contamination by use of the aflatoxin production inhibitor containing the dioctatin derivative. The present invention provides dioctatin derivatives represented by the following Structural Formula (I): | 12-18-2008 |
20080241879 | Microorganism and protease decomposing proteins recalcitrant to proteolysis - The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to | 10-02-2008 |