Metanomics GmbH Patent applications |
Patent application number | Title | Published |
20160047829 | Means and Methods for Determining a Clearance Normalized Amount of a Metabolite Disease Biomarker in a Sample - The present invention relates to a method for determining a clearance normalized amount of a metabolite disease biomarker in a sample including the steps of (a) determining the amount of the disease biomarker in at least a first type of sample of a subject suspected to suffer from the disease, (b) determining the amount of a kidney function biomarker which correlates with the glomerular filtration rate (GFR) in the said at least first type of sample, and (c) determining a clearance normalized amount for the metabolite disease biomarker by normalizing the amount determined for the metabolite disease biomarker in step (a) to the amount of the kidney function biomarker determined in step (b). Moreover, the invention also relates to a method for diagnosing a disease in a subject suspected to suffer therefrom and to a device for determining a clearance normalized amount of a metabolite disease biomarker in a sample. | 02-18-2016 |
20150160238 | Means and Methods for Diagnosing and Monitoring Heart Failure in a Subject - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 06-11-2015 |
20140325709 | PROCESS FOR THE PRODUCTION OF FINE CHEMICALS - The present invention relates to a process for the production of fine chemicals in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The present invention relates further to a process for the control of the production of fine chemicals in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use. | 10-30-2014 |
20140199313 | Process for the Production of Fine Chemicals - The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof, preferably in plastids. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use. | 07-17-2014 |
20140030744 | Means and Methods for Diagnosing Gastric Bypass and Conditions Related Thereto - The present invention relates to the field of diagnostic measures. Specifically, it contemplates a method for assessing whether gastric bypass therapy was successful in a subject, a method of predicting whether gastric bypass therapy will be beneficial for a subject in need thereof, and a method of diagnosing whether a supportive therapy accompanying gastric bypass has beneficial effects on a subject in need thereof. Further provided are diagnostic methods for diabetes and body lean mass. Furthermore, the invention relates to a method for identifying a treatment against diabetes and/or obesity. | 01-30-2014 |
20120286157 | Means and Methods for Diagnosing Heart Failure in a Subject - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 11-15-2012 |
20110271402 | INCREASE IN YIELD BY REDUCING GENE EXPRESSION - The present invention relates to a process for the increase in yield in a plant organism by reducing gene expression. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material and plants. | 11-03-2011 |
20100236321 | MEANS AND METHOD FOR PREDICTING DIABETES - The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites. | 09-23-2010 |
20100163720 | MEANS AND METHOD FOR DIAGNOSING DIABETES - The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites. | 07-01-2010 |
20100100982 | Preparation of Organisms with Faster Growth and/Or Higher Yield - A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, which method comprises increasing the activity of L450 in said organism or in one or parts thereof in comparison with a reference organism. | 04-22-2010 |
20100071091 | NUCLEIC ACID SEQUENCES ENCODING PROTEINS ASSOCIATED WITH ABIOTIC STRESS RESPONSE AND PLANT CELLS AND PLANTS WITH INCREASED TOLERANCE TO ENVIRONMENTAL STRESS - This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. This invention further relates to transformed plant cells with altered metabolic activity compared to a corresponding non-transformed, wild-type plant cell, wherein the metabolic activity is altered by transformation with a Stress-Related Protein (SRP) coding nucleic acid and results in increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed, wild-type plant cell. | 03-18-2010 |
20100050296 | Preparation of organisms with faster growth and/or higher yield - A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, with method comprises increasing the activity of SEQ ID NO: 2, 107, 125, 129 or 137 in said organism or in one or parts thereof in comparison with a reference organism. | 02-25-2010 |
20100031380 | IDENTIFICATION OF CHILLING-RESISTANT PLANTS - A process for identifying whether plant is resistant to chilling comprises cultivating the plant at a reduced temperature for a time period selected from short term and medium term; harvesting a tissue sample of the plant; measuring concentration of at least one metabolite in the tissue sample of the plant; comparing the measured concentration with the concentration of the same metabolite in a tissue sample harvested from a reference plant or a plant of the same species after cultivation at a reference temperature; and optionally, repeating the process of foregoing steps but cultivating the plant at a reduced temperature for a time period selected from short term and medium term and not previously used; wherein resistance to chilling is indicated by one or more of the effects on metabolites listed in Table 2 or Table 4. | 02-04-2010 |
20090300794 | Manipulation Of The Nitrogen Metabolism - The present invention relates to the manipulation of the nitrogen metabolism in photosynthetic active organisms, preferably in plants. In particular, the present invention relates to a process for the enhanced nitrogen assimilation, accumulation and/or utilization and/or for the increased total nitrogen content in a photosynthetic active organism. | 12-03-2009 |
20090263826 | MEANS AND METHOD FOR DIAGNOSING HEMOLYTIC ANEMIA - The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject. | 10-22-2009 |
20080318790 | Process for the Production of Fine Chemicals - The present invention relates to a process for the production of methionine in an organism such as a microorganism, a non-human animal or plant. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use. | 12-25-2008 |
20080234948 | System and Method for Characterizing a Chemical Sample - A method for characterizing a sample containing at least one compound, preferably a biological sample comprising at least one metabolite, is proposed. In a first process step, a three-dimensional first set of data is generated by analyzing the sample by using at least one time resolved separation technique ( | 09-25-2008 |
20080234945 | Means and Methods for Analyzing a Sample by Means of Chromatography-Mass Spectrometry - The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method. Moreover, the present invention further encompasses a system for carrying out said method comprising operatively linked to each other: (a) means for determining a compound; (b) means for monitoring process parameters, (c) means for analyzing raw results obtained from the means according to (a), wherein said means for analyzing raw results comprise: (i) a first database comprising raw results received from the means according to (a); (ii) a second database comprising monitored process parameters received from the means according to (b); (iii) a third database comprising rules for evaluating the raw results; and (iv) a fourth database comprising allocated results of identified compounds; wherein at least the second, third and fourth database are operatively linked to the first database. | 09-25-2008 |