| Mallinckrodt LLC Patent applications |
| Patent application number | Title | Published |
|---|
| 20150253213 | MEDICAMENT SACHET LEAK TESTING SYSTEM - A leak testing system ( | 09-10-2015 |
| 20150231325 | POWER INJECTOR WITH MOVABLE JOINT-INTEGRATED SIGNAL TRANSMISSION CONNECTOR - A power injector that incorporates at least one signal transmission connector in a movable joint (e.g., between a powerhead and a support or stand; between at least one adjacent pair of support sections of a support for the powerhead) is disclosed. Such a signal transmission connector may be in the form of a slip ring module, but in any case is part of the signal transmission link to the powerhead. At least that portion of a signal transmission conduit that is adjacent to the powerhead may be disposed within the interior of the corresponding portion of the support or stand, thereby reducing the potential that an individual will grab onto the signal transmission conduit when attempting to move at least part of the power injector, to change the position of the powerhead, or both. | 08-20-2015 |
| 20150127376 | CONTRAST MEDIA INJECTION DATA MANAGEMENT - Contrast administration data that relates to operation of a contrast media injector system ( | 05-07-2015 |
| 20150060684 | SYSTEMS AND METHODS FOR ASSAYING AN ELUATE FOR TECHNETIUM AND MOLYBDENUM CONTENT - A system for assaying an eluate for Technetium-99m and Molybdenum-99 content includes an inner ionization chamber including a well configured to receive the eluate, an outer ionization chamber concentric with the inner ionization chamber, and attenuating material positioned between the inner and outer ionization chambers. A computing device is configured to determine a Technetium-99m content of the eluate based on a first current measured in the inner ionization chamber, and determine a Molybdenum-99 content of the eluate based on at least a second current measured in the outer ionization chamber. | 03-05-2015 |
| 20150025374 | POWERHEAD OF A POWER INJECTION SYSTEM - A contrast media injection system includes detects the absolute position of the syringe ram using a non-contact sensor. A series of magnets and Hall-Effect sensors may be used or an opto-reflective system. Illuminated knobs that are connected to the drive mechanism for the syringe ram rotate with the drive and provide visual feedback on operation through the illumination. Analog Hall-Effect sensors are used to determine the presence or absence of magnets that identify the type of faceplate being used. The faceplates include control electronics, connected to the powerhead through connectors, which may be interchangeably used by the two faceplates. The faceplate electronics include detectors for automatically detecting the capacity of pre-filled syringes. Additional features include using historical data to provide optimum pressure limit values during an injection protocol, a removable memory device for storing and transferring information such as injection protocols and injector statistics, and password protection of such protocols. | 01-22-2015 |
| 20140364830 | INJECTOR AUTO PURGE - An auto purge for an intravenous contrast injector of the type having a motor which advances a plunger drive ram and configured for use with a pre-filled or user-filled syringe containing an approximate known amount of air including a processor which causes the motor to move and a memory storing a predetermined purge stop point representative of the approximate known amount of air in the syringe, the injector configured to automatically advance the plunger drive ram an amount substantially equal to the predetermined purge stop point representative of the approximate known amount of air contained in the syringe. | 12-11-2014 |
| 20140288113 | Extended Release Compositions Comprising Hydrocodone And Acetaminophen For Rapid Onset And Prolonged Analgesia That May Be Administered Without Regard To Food - The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof. | 09-25-2014 |
| 20140271822 | MODIFIED DOCETAXEL LIPOSOME FORMULATIONS - The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane. The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2′-O position with a heterocyclyl-(C | 09-18-2014 |
| 20140271821 | LIPOSOMAL CISPLATIN COMPOSITIONS FOR CANCER THERAPY - The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed. | 09-18-2014 |
| 20140271820 | LIPOSOME OXALIPLATIN COMPOSITIONS FOR CANCER THERAPY - The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-70 mol % of a phosphatidylcholine lipid, 25-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and oxaliplatin. Oxaliplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the oxaliplatin weight is from about 20:1 to about 65:1. Methods for the preparation of liposomal oxaliplatin and the treatment of cancer are also disclosed. | 09-18-2014 |
| 20140271465 | MATRIX METALLOPROTEASE (MMP) TARGETED AGENTS FOR IMAGING AND THERAPY - The present invention provides compound conjugates of matrix metalloprotease inhibitors and linked metal chelators which are useful for imaging solid tumors and treating and diagnosing certain types of diseases such as cancer. | 09-18-2014 |
| 20140264056 | SYSTEMS AND METHODS FOR ASSAYING AN ELUATE FOR TECHNETIUM AND MOLYBDENUM CONTENT - A system for assaying an eluate for Technetium-99m and Molybdenum-99 content includes an inner ionization chamber including a well configured to receive the eluate, an outer ionization chamber concentric with the inner ionization chamber, and attenuating material positioned between the inner and outer ionization chambers. A computing device is configured to determine a Technetium-99m content of the eluate based on a first current measured in the inner ionization chamber, and determine a Molybdenum-99 content of the eluate based on at least a second current measured in the outer ionization chamber. | 09-18-2014 |
| 20140231709 | Purification of Metals - A solid composition comprises:
| 08-21-2014 |
| 20140200367 | Synthesis of N1,N3-BIS(2,3-DIHYDROXYPROPYL)-5-NITROISOPHTHALAMIDE - The present disclosure generally relates to a new process for the preparation of high purity 5-nitro-isophthalamide compounds, which are useful as intermediates for the preparation of imaging agents, such as iodinated x-ray contrast imaging agents like ioversol, iohexyl and iopamidol. | 07-17-2014 |
| 20140170217 | COMBINATION COMPOSITION COMPRISING OXYCODONE AND ACETAMINOPHEN FOR RAPID ONSET AND EXTENDED DURATION OF ANALGESIA - The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof. | 06-19-2014 |
| 20140142537 | Injection System with Capacitive Sensing - A powerhead ( | 05-22-2014 |
| 20140105977 | GASTRIC RETENTIVE EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS - The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. | 04-17-2014 |
| 20140100172 | Cancer Imaging and Treatment - Provided herein are compounds useful for diagnostic imaging and/or therapeutic purposes. Each compound comprises a ligand for the chemokine receptor CXCR4, which has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of | 04-10-2014 |
| 20140088559 | Multi-Dose Medical Fluid Injection System Having Patient-Specific Tubing Set with Use Indicator - A single-use, single-patient, or patient-specific tubing set ( | 03-27-2014 |
| 20140086987 | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans - Methods for producing stabilized solid dosage form pharmaceutical compositions are provided. In particular, methods for preparing protected granules containing morphinans, and solid dosage form pharmaceutical compositions produced using the morphinan-protected granules are provided. | 03-27-2014 |
| 20140083900 | SEALABLE SECONDARY PACKAGING FOR PHARMACEUTICAL PRODUCT BLISTER PACK - A pharmaceutical product supply is disclosed in the form of a container, a pharmaceutical product receiver, pharmaceutical product, an adhesive, and at least one release liner. The pharmaceutical product receiver includes a plurality of receptacles for pharmaceutical product. The container is initially disposed in a first configuration where all of the pharmaceutical product receiver receptacles may be accessible. The container is thereafter disposable in a second configuration where no covering for any of the pharmaceutical product receiver receptacles is accessible through any openable access incorporated by the container. One or more release liners may be moved to expose adhesive for disposing and retaining the container in its second configuration. The noted second configuration of the container facilitates disposal of the pharmaceutical product supply (e.g., now being in a form that should reduce the potential for gaining access to any remaining pharmaceutical product still enclosed within the pharmaceutical product receiver). | 03-27-2014 |
| 20140031543 | (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives - The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention. | 01-30-2014 |
| 20130345644 | Hinge Assembly for an Injector - A locking hinge assembly for an injector is disclosed. The injector includes a forward handle member, a rear handle member and a hinge connecting the first and second members and defining an axis of rotation. The locking hinge assembly includes a hinge element slidable along the axis of rotation between a locked position and an unlocked position. The hinge element is coupled to the forward handle member and the rear handle member at the hinge, and the hinge element includes at least one groove. Additionally, a locking element is provided and positioned about the hinge. The locking element is configured to be received in the groove such that rotation of the forward handle member and rear handle member about the axis of rotation is prevented when the hinge element is in the locked configuration. | 12-26-2013 |
| 20130261338 | Process for the Preparation of Iosimenol - A process for the preparation of iosimenol comprising reacting 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3′4(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof. | 10-03-2013 |
| 20130245438 | SYRINGE MOUNT FOR A MEDICAL FLUID INJECTOR - In certain embodiments, a syringe mount of the invention may include a plate, an actuator, and one or more movable members located between the plate and the actuator. Each of the plate and the actuator may have an orifice defined therein, and an imaginary reference axis of the syringe mount may extend through one or both of these orifices. The actuator may be movable relative to the plate in a direction substantially perpendicular to the reference axis. Further, the moveable member(s) may be designed to move (e.g., pivot) toward the reference axis due to movement of the actuator from a first position to a second position and to move (e.g., pivot) away from the reference axis due to movement of the actuator from the second position to the first position. | 09-19-2013 |
| 20130237917 | POWER INJECTOR WITH FLOW RATE ASSESSMENT - A flow rate assessment protocol ( | 09-12-2013 |
| 20130237808 | FLUID DRIVEN MEDICAL INJECTORS - Some injectors of the invention may include a fluid drive responsive to pressure of a working fluid (e.g., liquid, pneumatic, or both) to impart a sequence of forces to drive a delivery device (e.g., a syringe) to deliver a medical fluid (e.g., a contrast agent, a radiopharmaceutical, a drug, or a combination thereof). Some injectors may include a multimedia tube configured to pass a working fluid (e.g., air) and a light signal (e.g., infrared). Some injectors may include a peristaltic drive responsive to pressure of a working fluid. | 09-12-2013 |
| 20130237558 | Stability of Hydromorphone Hydrochloride Solutions - The present invention relates generally to a sterile hydromorphone hydrochloride solution that is substantially free of buffer. | 09-12-2013 |
| 20130203999 | One Pot Process for Producing 6-Hydroxyl Nal-Opiate - The present invention provides processes for preparing nal-opiates without the isolation of intermediates. In general, the process provides for alkylation and reduction in the same pot to give the nal-opiate. | 08-08-2013 |
| 20130190617 | SYRINGE WITH VISUAL USE INDICATOR - Systems and methods are presented for the visual indication of whether a power injector has discharged fluid from a power injector syringe in a previous medical procedure. In this regard, the systems and methods generally provide for a power injector and a syringe for use with the power injector. The syringe includes a visual indicator that moves between a first state and a second state at approximately the same time that the power injector discharges fluid from the syringe such that an operator may view the change in state. | 07-25-2013 |
| 20130171046 | Purification of Metals - A solid composition comprises:
| 07-04-2013 |
| 20130144053 | Process for the Production of Seven-Membered Lactam Morphinans - The present invention relates to improved processes for preparing lactam morphinans. The processes generally transform keto-morphinans to seven-membered lactam morphinans using a hydroxyamine sulfonic acid reagent and proceed in high yield and with good selectivity. | 06-06-2013 |
| 20130137874 | One-Pot Preparation of Hexahydroisoquinolines from Amides - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 05-30-2013 |
| 20130131327 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging - Chelators of the formulae (I), (II) and (III) | 05-23-2013 |
| 20130129620 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging - Chelators of the formulae (I), (II) and (III) | 05-23-2013 |
| 20130115273 | Combinational Liposome Compositions for Cancer Therapy - The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome that induces release of the agents from the therapeutic liposome. | 05-09-2013 |
| 20130087475 | SEALABLE SECONDARY PACKAGING FOR PHARMACEUTICAL PRODUCT BLISTER PACK - A pharmaceutical product supply is disclosed in the form of a container, a pharmaceutical product receiver, pharmaceutical product, an adhesive, and at least one release liner. The pharmaceutical product receiver includes a plurality of receptacles for pharmaceutical product. The container is initially disposed in a first configuration where all of the pharmaceutical product receiver receptacles may be accessible. The container is thereafter disposable in a second configuration where no covering for any of the pharmaceutical product receiver receptacles is accessible through any openable access incorporated by the container. One or more release liners may be moved to expose adhesive for disposing and retaining the container in its second configuration. The noted second configuration of the container facilitates disposal of the pharmaceutical product supply (e.g., now being in a form that should reduce the potential for gaining access to any remaining pharmaceutical product still enclosed within the pharmaceutical product receiver). | 04-11-2013 |
| 20130066203 | Power Injector with Ram Retraction - Various embodiments of syringe plunger driver or ram retraction protocols for a power injector are disclosed. In a first ram retraction protocol ( | 03-14-2013 |
| 20130066098 | Remote Assembly of Targeted Nanoparticles using H-Phosphate ENE/-YNE Hydrophosphonylation Reactions - The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications. | 03-14-2013 |
| 20130066086 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES - The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a nanoparticle to increase in vivo circulation times and targeted delivery performance. | 03-14-2013 |
| 20130066080 | Production of Alkaloids without the Isolation of Intermediates - The invention relates to processes for the production of alkaloids without the isolation of intermediates. | 03-14-2013 |
| 20130035488 | Stepwise Process for the Production of Alkaloid Salts - The present invention provides to an improved process for preparing alkaloid salts. In particular, the process comprises a stepwise addition of an acid to an alkaloid chosen from hydrocodone, codeine, and dihydrocodeine to form a flowable mixture of the alkaloid salt. | 02-07-2013 |
| 20130030291 | Drive Ram for Medical Injectors - A drive ram for use with a medical fluid injector may include a central, longitudinal reference axis. First and second gripper members may be pivotally interconnected with a plunger engaging end of the drive ram. Each of the first and second gripper members may be pivotable about a common pivot axis that intersects the reference axis. Each of the gripper members may further include a first end that is remote from the common pivot axis. In some embodiments, the first and second gripper members may be pivotable between a first position and a second position. In the first position, the first ends of the gripper members may be spaced apart by a first distance, while in the second position, they may be spaced apart by a second distance that is greater than the first distance. | 01-31-2013 |
| 20130029073 | PROTECTIVE SHROUD FOR NUCLEAR PHARMACY GENERATORS - A protective shroud is provided for covering a radiation shield that surrounds a nuclear pharmacy generator. The radiation shield includes components having seams therebetween. The protective shroud includes a tubular body configured to contain the radiation shield, a first opening adapted for receiving the radiation shield, and a second opening for allowing access into the radiation shield. | 01-31-2013 |
| 20120316343 | Reductive Amination of 6-Keto Morphinans by Catalytic Hydrogen Transfer - The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched. | 12-13-2012 |
| 20120305800 | Holder and Tool For Radioisotope Elution System - A holder for a vial containing a sterile liquid for use with a radiopharmaceutical elution system includes a holder body. The body has a top, an opposing bottom, an opening in the top and a vial chamber. The vial chamber extends from the opening in the top toward the bottom and is sized and shaped for receiving the vial therein. An access opening extends through the bottom to the vial chamber and is aligned with a septum of the elution vial when the sterile vial is received in the vial chamber. A cap is removably secured to the top of the holder body for selectively opening and closing the vial chamber. The holder body includes plastic and has a density less than the density of the cap. | 12-06-2012 |
| 20120305429 | Radioisotope Elution System - An elution tool for a radiopharmaceutical elution system includes an elution tool. The tool has a vial chamber sized and shaped for receiving an elution vial. An access opening is aligned with a septum of the elution vial when the elution vial is received in the vial chamber. An elution tool lid is secured to the elution tool body by a hinged connection. The elution tool lid is rotatable at the hinged connection and movable relative to the elution tool body between an occluded position and an exposed position. The tool also includes a latching mechanism for selectively and releasably locking the lid in the occluded position. | 12-06-2012 |
| 20120298880 | Self-Aligning Radioisotope Elution System and Method - A radioisotope elution system including a radioisotope generator having an alignment structure. The alignment structure may be configured to interface with a complementary alignment structure of an auxiliary radiation shield assembly. | 11-29-2012 |
| 20120289884 | Fused Ring Diarylamino Photosensitizers for Phototherapy - The invention relates generally to optical agents and methods of using optical agents for biomedical applications, including phototherapy. Provided are methods of using diarylamino compounds having a fused ring backbone providing phototherapeutic agents, including Type 1 phototherapeutic agents. Optical agents of the invention enable a versatile phototherapy platform for treatment of a range of pathological conditions, including the treatment of cancers, stenosis and inflammation. The invention further provides preparations and formulations comprising the diarylamino optical agents and related methods of making and using diarylamino optical agents in an in vivo or ex vivo biomedical procedure. | 11-15-2012 |
| 20120277421 | Metal Complexes of Tetraazamacrocycle Derivatives - Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof. | 11-01-2012 |
| 20120222702 | Target Bodies and Uses Thereof in the Production of Radioisotope Materials - A system and method are provided for reclaiming an enriched radioisotope starting material from a target body. The system and method enable reclaiming the starting material in a relatively short time (e.g., several hours) after the target body's bombardment with energetic particles, greatly simplifying the target body's chemical processing, as well as reducing the cost of such processing (e.g., reducing the need for costly long-term storage). Specifically, a chemical protective layer is disposed between a radioisotope starting material and a base material of the target body. After the target body is irradiated with a suitable source (e.g., particle accelerator), then the irradiated radioisotope starting material can be removed without removing the base material due to the protection provided by the chemical protective layer. The system and method also enable the operator to obtain three different radioisotopes in a single bombardment of the target body, further reducing cost of radioisotope production. | 09-06-2012 |
| 20120203102 | AZULENE AND AZAAZULENE SYSTEMS FOR IMAGING, MONITORING AND THERAPY - This invention is directed to non-benzenoid aromatic compounds. Other aspects include methods of using non-benzenoid aromatic compounds for imaging and phototherapeutic uses thereof. Non-benzenoid compounds provided herein generally have one or more substituent groups which allow tailoring of the spectral properties or provide photoreactivity or targeting ability. | 08-09-2012 |
| 20120187316 | Radiation Shielding Lid For An Auxiliary Shield Assembly of A Radioisoptope Elution System - Disclosed herein are embodiments of a radiation shielding lid of a radiation shielding container (e.g., auxiliary radiation shield) designed to house a radioisotope generator assembly. | 07-26-2012 |
| 20120184773 | REDUCTION OF FUSED BICYCLIC IMPURITIES IN TRIIODINATED X-RAY CONTRAST MEDIA - The present disclosure generally relates to an improved process for alkylating a triiodo-substituted arylamide to form a compound suitable for use as an X-ray contrast agent. More particularly, the present disclosure is directed to such a process that limits the formation of fused bicyclic impurities, such as Impurity G, in the alkylation reaction mixture. | 07-19-2012 |
| 20120134930 | Pyrazine Derivatives for Bioconjugation - Provided are compounds and compositions of general Formula IX: E1-L-Ar-X-PA, that may be utilized in bioconjugation procedures, where Ar is a chromophore and PA is a functional group capable of being attached to any bioactive molecule of interest. The present invention provides Formulas I-III that are capable of being attached to a bioactive vector for the selective delivery of said photoactive pyrazine derivatives to a desired biological target. | 05-31-2012 |
| 20120116086 | Sinomenine Derivatives and Processes for their Synthesis - The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates. | 05-10-2012 |
| 20120100078 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II below. | 04-26-2012 |
| 20120090278 | DISPOSABLE TRANSDERMAL PATCH CONTAINMENT - Various embodiments of transdermal patch disposal devices are disclosed. Each such disposal device utilizes a containment having a patch disposal slot. A transdermal patch may be directed through this patch disposal slot for retention within an internal chamber of the containment. This patch disposal slot may be configured to reduce the potential of being able to withdraw a transdermal patch back out of the containment through the patch disposal slot. The interior of the containment may include one or more ribs which may reduce the potential of being able to withdraw a transdermal patch back out of the containment through the patch disposal slot. | 04-19-2012 |
| 20120082616 | Aptamer Conjugates for Targeting of Therapeutic and/or Diagnostic Nanocarriers - The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject. | 04-05-2012 |
| 20120071659 | Process for the Preparation of Sufentanil Base and Related Compounds - The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques. | 03-22-2012 |
| 20120035367 | Tandem Process for Preparing N-Alkyl Morphinans - The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans. | 02-09-2012 |
| 20120035366 | N-Demethylation of 6-Keto Morphinans - The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan. | 02-09-2012 |
