JAPAN HEALTH SCIENCES FOUNDATION Patent applications |
Patent application number | Title | Published |
20130337438 | MONOCLONAL ANTIBODY RECOGNIZING HUMAN PAPILLOMAVIRUS (HPV) L2 PROTEIN AND METHOD FOR MEASURING HPV-NEUTRALIZING ANTIBODY TITER USING THE SAME - The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody. | 12-19-2013 |
20120322025 | METHOD FOR FORMING DENTAL COATING AND DENTAL CAD/CAM DEVICE - A dental CAD/CAM device capable of accurately forming a dental coating is provided. The device includes: an intraoral-site measurement section | 12-20-2012 |
20120264928 | THERAPEUTIC PHARMACEUTICAL AGENT FOR DISEASES ASSOCIATED WITH DECREASE IN FUNCTION OF GNE PROTEIN, FOOD COMPOSITION, AND FOOD ADDITIVE - Disclosed are a therapeutic pharmaceutical agent for diseases associated with the decrease in the function of GNE protein, a food composition, and a food additive. The therapeutic pharmaceutical agent is characterized by comprising a compound capable of increasing the quantity of N-acetylneuraminic acid in cells. Examples of the compound to be contained in the therapeutic pharmaceutical agent include N-acetylneuraminic acid, an intermediate produced downstream from N-acetylmannosamine in an N-acetylneuraminic acid biosynthesis pathway, an N-acetylneuraminic acid derivative, an N-acetylmannosamine derivative, an N-acetylneuraminic acid-containing compound, an N-acetylneuraminic acid derivative-containing compound, an N-acetylmannosamine-containing compound, an N-acetylmannosamine derivative-containing compound, an inhibitor of a degrading enzyme for N-acetylneuraminic acid, an inhibitor of a degrading enzyme for N-acetylmannosamine, an inhibitor of a degrading enzyme for the intermediate, and others. | 10-18-2012 |
20120231970 | COLON CANCER MARKER AND METHOD FOR TESTING FOR COLON CANCER - Provided are a micro RNA which can be used as a colon cancer marker, a method for testing for colon cancer which uses the micro RNA which can be used as a colon cancer marker, and a test kit which can be used for the testing method. The colon cancer marker includes micro RNA molecules which are represented by any of the sequences 1 through 25. The method for testing for colon cancer in a subject involves preparing a sample, which contains a micro RNA molecule derived from the subject's colon tissue or colon cell, and detecting a micro RNA molecule represented by any of the sequences 1 through 25 present in the obtained sample. | 09-13-2012 |
20120231490 | Method Of Differentiation From Stem Cells To Hepatocytes - Disclosed are: a gene transduction method for use in the induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes effectively; stem cells into each of which a gene useful for the induction of the differentiation into hepatocytes is introduced; and hepatocytes produced from stem cells each having the gene introduced therein. A specific gene can be introduced into stem cells such as ES cells or iPS cells using an adenovirus vector. The effective induction of the differentiation into hepatocytes can be achieved by introducing the gene. Specifically, the effective induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes can be achieved by introducing at least one gene selected from HEX gene, HNF4A gene, HNF6 gene and SOX17 gene into the stem cells. | 09-13-2012 |
20110243910 | MAMMALIAN RNA DEPENDENT RNA POLYMERASE - The invention provides compositions comprising a TERT-RMRP or TERT-RNA complex and methods of treating subjects with genetic diseases in which gene silencing is either increased by administering the compositions of the invention or decreased by administering an inhibitor of the RNA-dependent RNA polymerase (RdRP) activity of these compositions. Moreover, the invention provides methods of screening for agonists and antagonists of RdRP activity and TERT-RMRP complex formation. Finally, the invention provides a method of identifying a RNA molecule that forms a complex with a TERT polypeptide and has RdRP activity. | 10-06-2011 |
20110098767 | SYSTEM FOR AUTOMATICALLY MINIMIZING CARDIAC OXYGEN CONSUMPTION AND CARDIAC DISEASE TREATING SYSTEM USING THE SAME - [PROBLEMS] A system for automatically minimizing cardiac oxygen consumption that is capable of estimating a patient's amount of cardiac oxygen consumption with high accuracy and moreover capable of minimizing the amount of cardiac oxygen consumption and a cardiac disease treating system are provided. | 04-28-2011 |
20110020310 | ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD - Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler ( | 01-27-2011 |
20100183648 | VACCINE ANTIGEN CAPABLE OF INDUCING CROSS-REACTING AND NEUTRALIZING ANTIBODY AGAINTS HIGH-RISK-TYPE HUMAN PAPILLOMAVIRUS - Disclosed is a vaccine antigen capable of inducing a cross-reacting and neutralizing antibody directed against a high-risk-type human papillomavirus. Specifically disclosed are: a chimeric protein comprising an L2-epitope of a human papillomavirus (HPV) type-16 inserted in a loop region of a human papillomavirus type-16 L1 protein; and a capsid which is an aggregate of the chimeric protein. The loop region to which the L2-epitope is to be inserted is located between an amino acid residue at position-430 and an amino acid residue at position-433. The L2-epitope has an amino acid sequence represented by any one of the following formulae: YKTCKQAGTCPPDIIPKVEG (SEQ ID NO: 2) (18-32 L2-epitope); GGLGIGTGSGTGGRTGYIPL (SEQ ID NO: 3) (56-75 L2-epitope); and DPVGPLDPSIVSLVEESSFI (SEQ ID NO: 4) (96-115 L2-epitope). | 07-22-2010 |
20100171041 | TOMOGRAPH, TOMOGRAPHY, TOMOGRAPHY PROGRAM, AND COMPUTER-READABLE RECORDING MEDIUM WHERE THE PROGRAM IS RECORDED - The invention provides a tomograph, and a tomography method, that is capable of providing reconstructed images of high resolution without truncation for large subjects such as a human body. | 07-08-2010 |
20100147780 | FILTER FOR FILTRATION AND RECOVERY OF SUSPENDED PARTICLES IN WATER, AND METHOD FOR FILTRATION AND RECOVERY OF SUSPENDED PARTICLES IN WATER AND METHOD FOR WATER QUALITY MANAGEMENT USING THE FILTER - The present invention provides a novel filter for filtration and recovery of suspended particles in water, which can filtrate the suspended particles in water simply and fast as well as recover the particles efficiently, and a method for filtration and recovery. The method involves the process of physically filtrating suspended particles in water using a filter comprised of soluble powder layered on a support and then dissolving the soluble powder of the filter in acid to recover the suspended particles filtrated. | 06-17-2010 |
20090306552 | ULTRASONIC MEDICAL APPARATUS - The present invention solves the issue of bacterial infection by medical devices such as intracorporeal indwelling catheters. The present invention relates to an ultrasonic medical apparatus including a medical device (titanium oxide coated medical device | 12-10-2009 |
20090221923 | Cardiac Disease Treatment System - Problems To provide a cardiac disease treatment system for accurately diagnosing the functional cause of an abnormality of a cardiac disease by analyzing the hemodynamic state of a patient, automatically performing medication in accordance with the diagnosis result, and treating the cardiac disease.
| 09-03-2009 |
20090215081 | SCREENING METHOD FOR ANTICANCER DRUG - The screening method for an anticancer drug comprises selecting a compound which blocks the kinase activity of TNIK, or blocks the combination of TNIK with β-catenin/TC4 transcription complex. | 08-27-2009 |
20090175825 | INTERFERON ALPHA AND ANTISENSE K-RAS RNA COMBINATION GENE THERAPY - An antiproliferative effect of IFN-α gene transduction in pancreatic cancer cells. The invention relates to expression of IFN-α to effectively induce growth suppression and cell death in pancreatic cancer cells, an effect which appeared to be more prominent when compared with other types of cancers and normal cells. Another aspect of the invention relates to targeting the characteristic genetic aberration, K-ras point mutation, in pancreatic cancer, and that the expression of antisense K-ras RNA significantly suppresses the growth of pancreatic cancer cells. When these two gene therapy strategies are combined, the expression of antisense K-ras RNA significantly enhanced IFN-α-induced cell death (1.3-3.5 fold), and suppressed subcutaneous growth of pancreatic cancer cells in mice. The invention also relates to a method of suppressing pancreatic cancer cells using double strand RNA formed by antisense and endogeneous K-ras RNA in combination with the anti-tumor activity of IFN-α. The invention relates to the combination of IFN-α and antisense K-ras RNA as an effective gene therapy strategy against pancreatic cancer. The invention also relates to a method of treating pancreatic cancer cells disseminated throughout the body by administering the inventive combination to localized pancreatic cancer cell tumor. The invention also relates to inducing indirect immunological antitumor activity to provide systemic immunity against pancreatic cancer cells. | 07-09-2009 |
20090053277 | Cell Sheet Containing Mesenchymal Stem Cells - Mesenchymal stem cells are pluripotent cells capable of differentiating into myocardial and vascular endothelial cells. The present invention demonstrates that the mesenchymal stem cell sheet have therapeutic potential for a severely damaged heart due to its pluripotency and in situ self-renewal capability. Mesenchymal stem cells derived from adipose tissue were cultured to prepare a mesenchymal stem cell sheet. Four weeks after induction of myocardial infarction in rats, the mesenchymal stem cell sheet was transplanted to the heart. The mesenchymal stem cell sheet were readily engrafted to the surface of the scarred myocardium, grew gradually in situ, and formed a thick layer (approximately 600 μm) in 4 weeks. The grown transplanted mesenchymal tissue contained newly formed blood vessels, myocardial cells, and undifferentiated mesenchymal cells. The engrafted mesenchymal stem cells inhibited thinning of the myocardial wall in the scar area, and improved cardiac function and survival rate in rats with myocardial infarcts. Thus, mesenchymal stem cell sheet transplantation may represent a novel therapeutic approach for myocardial tissue regeneration. | 02-26-2009 |
20090004671 | Marker Protein For Use In Diagnosis Of Pancreatic Cancer - Disclosed herein are a pancreatic carcinoma marker protein that is a blood protein having a molecular weight of 28,080±15, 17,272±9, 17,253±9, 8,766±5, or 14,779±8 (m/z) and a method for detecting pancreatic carcinoma using the marker protein as an indicator. | 01-01-2009 |
20080254136 | Antiprotozoal Agent - The present invention provides an antiprotozoal agent, which is particularly preferred as an antileishmanial agent. Specifically, the present invention is directed to an antiprotozoal agent comprising, as an active ingredient, a compound of Formula (I): | 10-16-2008 |